Compounds > 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.76)18.7374
1990's9 (42.86)18.2507
2000's8 (38.10)29.6817
2010's3 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, IS; Kim, SB; Nagao, M; Nagaoka, H; Nukaya, H; Ochiai, M; Sugimura, T; Tada, A; Tanaka, Y; Wakabayashi, K1
Dragsted, L; Farmer, P; Frandsen, H; Larsen, JC; Nielsen, PA; Rasmussen, ES1
Buonarati, MH; Felton, JS; Minkler, JL; Thompson, LH; Tucker, JD; Wu, RW1
Buonarati, MH; Felton, JS1
Alexander, J; Brunborg, G; Holme, JA; Hongslo, JK; Søderlund, EJ; Wallin, H1
Fan, L; Schut, HA; Snyderwine, EG1
Hatanaka, M; Ishidate, M; Miura, KF; Otsuka, C; Satoh, T; Wakabayashi, K1
Dubuisson, JG; Gaubatz, JW1
Falany, CN; Kadlubar, FF; King, RS; Lewis, AJ; Walle, T; Walle, UK1
Agarwal, R; Callaway, A; Schut, HA; Snyderwine, EG; Venugopal, M1
Alexander, J; Frandsen, H1
Grover, PL; Hewer, A; Martin, FL; Muir, GH; Phillips, DH; Williams, JA1
De Marzo, AM; Groopman, JD; Isaacs, WB; Kensler, TW; Kidd, LC; Nelson, CP; Nelson, WG; Sauvageot, J1
Felton, JS; Malfatti, MA1
Alexander, J; Frandsen, H; Frederiksen, H1
Devanaboyina, US; Doll, MA; Fretland, AJ; Hein, DW; Xiao, GH; Zhao, S1
Felton, JS; Malfatti, MA; Ubick, EA1
Amin, S; Blevins-Primeau, AS; Chen, G; Dellinger, RW; Krzeminski, J; Lazarus, P1
Beijnen, JH; Rosing, H; Schellens, JH; Schinkel, AH; Teunissen, SF; Vlaming, ML1
Dasari, S; Peng, L; Tabb, DL; Turesky, RJ1
Schebb, NH; Steinberg, P; von Elsner, L; Willenberg, I1

Other Studies

21 other study(ies) available for 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine and 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

ArticleYear
Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:10

    Topics: Acetic Anhydrides; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Deoxyguanosine; Guanine; Imidazoles; Isotope Labeling; Magnetic Resonance Spectroscopy; Mutagens; Nucleotides; Phosphates; Phosphorus Radioisotopes; Pyridines; Spectrometry, Mass, Fast Atom Bombardment

1992
Metabolic formation, synthesis and genotoxicity of the N-hydroxy derivative of the food mutagen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP).
    Mutagenesis, 1991, Volume: 6, Issue:1

    Topics: Animals; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Female; Food; Imidazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Mutagens; Mutation; Nitroimidazoles; Polychlorinated Biphenyls; Pyridines; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sister Chromatid Exchange

1991
Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2.
    Mutagenesis, 1991, Volume: 6, Issue:4

    Topics: Animals; Biotransformation; Cell Line; Chromosome Aberrations; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Gene Expression; Imidazoles; Micronucleus Tests; Microsomes; Mutagens; Oxidoreductases; Pyridines; Sister Chromatid Exchange

1991
Activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to mutagenic metabolites.
    Carcinogenesis, 1990, Volume: 11, Issue:7

    Topics: Acetyl Coenzyme A; Animals; Glutathione; Imidazoles; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; Phosphoadenosine Phosphosulfate; Pyridines; Salmonella typhimurium

1990
Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite.
    Carcinogenesis, 1989, Volume: 10, Issue:8

    Topics: Animals; Aroclors; Biotransformation; Cell Line; Cell Nucleus; Cells, Cultured; Chlorodiphenyl (54% Chlorine); DNA Damage; DNA Repair; DNA Replication; Food; Imidazoles; Kinetics; Liver; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Pyridines; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sister Chromatid Exchange

1989
Cytotoxicity, DNA adduct formation and DNA repair induced by 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline and 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in cultured human mammary epithelial cells.
    Carcinogenesis, 1995, Volume: 16, Issue:4

    Topics: Breast; Carcinogens; Cell Survival; Cells, Cultured; DNA; DNA Adducts; DNA Repair; Epithelium; Formazans; Humans; Imidazoles; Mutagens; Pyridines; Quinolines; Tetrazolium Salts

1995
Cytogenetic effects of a food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-beta]pyridine (PhIP), and its metabolite, 2-hydroxyamino-1-methy-6-phenylimidazo[4,5-beta]pyridine (N-OH-PhIP), on human and Chinese hamster cells in vitro.
    Mutation research, 1996, Mar-01, Volume: 367, Issue:3

    Topics: Adult; Animals; Biotransformation; Cells, Cultured; CHO Cells; Chromosome Aberrations; Cricetinae; Female; Fibroblasts; Humans; Imidazoles; Lymphocytes; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Pyridines; Rats; Rats, Sprague-Dawley; Sister Chromatid Exchange

1996
Bioactivation of the proximal food mutagen 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) to DNA-binding species by human mammary gland enzymes.
    Nutrition (Burbank, Los Angeles County, Calif.), 1998, Volume: 14, Issue:9

    Topics: Acetyltransferases; Adult; Amino Acyl-tRNA Synthetases; Animals; Biotransformation; Cells, Cultured; DNA; DNA Adducts; Enzyme Activation; Epithelial Cells; Esterification; Female; Food; Humans; Imidazoles; Mammary Glands, Animal; Middle Aged; Mutagens; Pyridines; Sulfotransferases

1998
Bioactivation of the cooked food mutagen N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells.
    Carcinogenesis, 1998, Volume: 19, Issue:11

    Topics: Biotransformation; Breast; Cells, Cultured; DNA; Female; Humans; Imidazoles; Mutagens; Pyridines; Sulfotransferases

1998
Inhibition of cell death in human mammary epithelial cells by the cooked meat-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine.
    Biochemical and biophysical research communications, 1999, Dec-09, Volume: 266, Issue:1

    Topics: Apoptosis; bcl-X Protein; Breast; Carcinogens; Cell Line; Cell Nucleus; Culture Media, Serum-Free; DNA Adducts; Epithelial Cells; Hot Temperature; Humans; Imidazoles; Meat; Mitogen-Activated Protein Kinase 1; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Time Factors

1999
N-acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of 2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,
    Carcinogenesis, 2000, Volume: 21, Issue:6

    Topics: Animals; Arylamine N-Acetyltransferase; Biomarkers; Biotransformation; Chromatography, High Pressure Liquid; Glutathione; Humans; Imidazoles; Male; Pyridines; Rats; Rats, Wistar

2000
Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue.
    Carcinogenesis, 2000, Volume: 21, Issue:9

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA; Gene Expression; Humans; Imidazoles; Male; Organ Culture Techniques; Prostatectomy; Prostatic Hyperplasia; Pyridines; Quinolines; RNA, Messenger

2000
Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.
    Cancer research, 2001, Jan-01, Volume: 61, Issue:1

    Topics: Adenocarcinoma; Aged; Biotransformation; Carcinogens; Cytosol; DNA; DNA Adducts; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imidazoles; Isoenzymes; Male; Middle Aged; Prostate; Prostatic Neoplasms; Pyridines; Transfection; Tumor Cells, Cultured

2001
N-glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N_hydroxy-PhIP by specific human UDP-glucuronosyltransferases.
    Carcinogenesis, 2001, Volume: 22, Issue:7

    Topics: Biotransformation; Carcinogens; Cell Line; Chromatography, High Pressure Liquid; Glucuronosyltransferase; Humans; Imidazoles; Microsomes; Pyridines; Spectrometry, Mass, Electrospray Ionization

2001
2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:8

    Topics: Administration, Oral; Animals; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Environmental Monitoring; Feces; Humans; Imidazoles; Male; Pyridines; Rats; Rats, Wistar

2002
Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 74, Issue:2

    Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Cricetinae; Cytosol; DNA; DNA Adducts; Genotype; Imidazoles; Male; Mesocricetus; Polymorphism, Genetic; Pyridines

2003
The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo.
    Carcinogenesis, 2005, Volume: 26, Issue:11

    Topics: Animals; beta-Naphthoflavone; Carcinogens; Chromatography, High Pressure Liquid; Colon; DNA Adducts; Enzyme Inhibitors; Glucuronides; Glucuronosyltransferase; Imidazoles; Immunoblotting; Inactivation, Metabolic; Liver; Male; Mass Spectrometry; Microsomes, Liver; Pyridines; Rats; Rats, Gunn; Rats, Wistar

2005
Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.
    Carcinogenesis, 2007, Volume: 28, Issue:11

    Topics: Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Glucuronides; Glucuronosyltransferase; Humans; Imidazoles; Kinetics; Mass Spectrometry; Pyridines

2007
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2010, Sep-01, Volume: 878, Issue:25

    Topics: Acetonitriles; Animals; Bodily Secretions; Chromatography, High Pressure Liquid; Digestive System; Drug Stability; Feces; Humans; Imidazoles; Linear Models; Mice; Pyridines; Reproducibility of Results; Tandem Mass Spectrometry

2010
Mapping serum albumin adducts of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by data-dependent tandem mass spectrometry.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Amino Acid Sequence; Animals; Carcinogens; Cooking; Dipeptidases; Humans; Imidazoles; Leucyl Aminopeptidase; Meat; Molecular Sequence Data; Nitroimidazoles; Oxidation-Reduction; Pronase; Pyridines; Serum Albumin; Tandem Mass Spectrometry; Trypsin

2012
Development of an online-SPE-LC-MS method for the investigation of the intestinal absorption of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and its bacterial metabolite PHIP-M1 in a Caco-2 Transwell system.
    Food chemistry, 2015, Jan-01, Volume: 166

    Topics: Caco-2 Cells; Carcinogens; Chromatography, Liquid; Humans; Imidazoles; Intestinal Absorption; Pyridines; Solid Phase Extraction; Tandem Mass Spectrometry; Toxicity Tests

2015