2-hydroxy-6-methylpurine has been researched along with allopurinol in 8 studies
| Studies (2-hydroxy-6-methylpurine) | Trials (2-hydroxy-6-methylpurine) | Recent Studies (post-2010) (2-hydroxy-6-methylpurine) | Studies (allopurinol) | Trials (allopurinol) | Recent Studies (post-2010) (allopurinol) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 15,096 | 743 | 3,363 |
| Protein | Taxonomy | 2-hydroxy-6-methylpurine (IC50) | allopurinol (IC50) |
|---|---|---|---|
| Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | Rattus norvegicus (Norway rat) | 3.3765 | |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | 3.1861 | |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | 5.0758 | |
| Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | 8.69 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hille, R; McWhirter, RB | 1 |
| Britt, RD; Hille, R; Kim, JH; Lorigan, GA | 1 |
| Hemann, C; Hille, R; Kim, JH | 1 |
| Hille, R; Kim, JH; Knaut, H; Ryan, MG | 1 |
| Jones, L; Kim, JH; Odutola, JA; Popham, J; von Laven, S | 1 |
| Choi, EY; Hille, R; Hoffman, BM; Manikandan, P | 1 |
| Bell, CE; Hille, R; Pauff, JM; Zhang, J | 1 |
| Metz, S; Thiel, W | 1 |
8 other study(ies) available for 2-hydroxy-6-methylpurine and allopurinol
| Article | Year |
|---|---|
The reductive half-reaction of xanthine oxidase. Identification of spectral intermediates in the hydroxylation of 2-hydroxy-6-methylpurine.
Topics: Aerobiosis; Anaerobiosis; Animals; Cattle; Electron Spin Resonance Spectroscopy; Female; Flavin-Adenine Dinucleotide; Hydroxylation; Kinetics; Milk; Oxidation-Reduction; Purines; Spectrophotometry; Xanthine Oxidase | 1991 |
Electron spin echo envelope modulation spectroscopy of the molybdenum center of xanthine oxidase.
Topics: Deuterium; Electron Spin Resonance Spectroscopy; Molecular Structure; Molybdenum; Purines; Xanthine Oxidase | 1994 |
Reductive half-reaction of xanthine oxidase: mechanistic role of the species giving rise to the "rapid type 1" molybdenum(V) electron paramagnetic resonance signal.
Topics: Animals; Cattle; Electron Spin Resonance Spectroscopy; Female; Flavin-Adenine Dinucleotide; Kinetics; Milk; Molybdenum; Oxidation-Reduction; Purines; Spectrophotometry; Time Factors; Xanthine; Xanthine Oxidase; Xanthines | 1993 |
The reductive half-reaction of xanthine oxidase. The involvement of prototropic equilibria in the course of the catalytic sequence.
Topics: Catalysis; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Molybdenum; Oxidation-Reduction; Pteridines; Purines; Solvents; Substrate Specificity; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
Tautomeric energetics of xanthine oxidase substrates: xanthine, 2-oxo-6-methylpurine, and lumazine.
Topics: Catalysis; Energy Metabolism; In Vitro Techniques; Isomerism; Pteridines; Purines; Quantum Theory; Substrate Specificity; Thermodynamics; Xanthine; Xanthine Oxidase | 2001 |
35 GHz ENDOR characterization of the "very rapid" signal of xanthine oxidase reacted with 2-hydroxy-6-methylpurine (13C8): evidence against direct Mo-C8 interaction.
Topics: Electron Spin Resonance Spectroscopy; Purines; Xanthine Oxidase | 2001 |
Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine.
Topics: Animals; Binding Sites; Catalysis; Cattle; Crystallography, X-Ray; Humans; Hyperuricemia; Molybdenum; NAD; Protein Binding; Protein Structure, Tertiary; Purines; Xanthine Oxidase | 2008 |
QM/MM studies of xanthine oxidase: variations of cofactor, substrate, and active-site Glu802.
Topics: Catalytic Domain; Coenzymes; Glutamic Acid; Models, Molecular; Mutagenesis; Mutation; Purines; Quantum Theory; Thermodynamics; Xanthine Oxidase | 2010 |