2-hexynyladenosine-5'-n-ethylcarboxamide and adenosine-5'-(n-ethylcarboxamide)

2-hexynyladenosine-5'-n-ethylcarboxamide has been researched along with adenosine-5'-(n-ethylcarboxamide) in 24 studies

Compound Research Comparison

Studies (2-hexynyladenosine-5'-n-ethylcarboxamide)	Trials (2-hexynyladenosine-5'-n-ethylcarboxamide)	Recent Studies (post-2010) (2-hexynyladenosine-5'-n-ethylcarboxamide)	Studies (adenosine-5'-(n-ethylcarboxamide))	Trials (adenosine-5'-(n-ethylcarboxamide))	Recent Studies (post-2010) (adenosine-5'-(n-ethylcarboxamide))
28	0	2	1,333	4	133

Protein Interaction Comparison

Protein	Taxonomy	adenosine-5'-(n-ethylcarboxamide) (IC50)
Adenosine receptor A3	Homo sapiens (human)	0.0097
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	0.037
Adenosine receptor A1	Rattus norvegicus (Norway rat)	0.4498
Adenosine receptor A2a	Homo sapiens (human)	0.0336
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	0.0175
Adenosine receptor A1	Homo sapiens (human)	0.0007
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	0.0513
Adenosine receptor A1	Gallus gallus (chicken)	0.017

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (83.33)	18.2507
2000's	3 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (4.17)	2.80

Authors

Authors	Studies
Abiru, T; Homma, H; Matsuda, A; Murayama, T; Nomura, Y; Watanabe, Y	1
Cristalli, G; Eleuteri, A; Klotz, KN; Lohse, MJ; Vittori, S; Volpini, R	1
Cristalli, G; Esker, JL; Jacobson, KA; Ji, XD; Melman, N; Olah, ME; Schneller, SW; Secrist, JA; Siddiqi, SM; Tiwari, KN	1
Borea, PA; Camaioni, E; Conti, A; Cristalli, G; Dionisotti, S; Monopoli, A; Ongini, E; Vittori, S; Volpini, R	1
Camaioni, E; Conti, A; Cristalli, G; Dionisotti, S; Monopoli, A; Ongini, E; Vittori, S; Volpini, R; Zocchi, C	1
Camaioni, E; Cristalli, G; Di Francesco, E; Dionisotti, S; Monopoli, A; Ongini, E; Vittori, S; Volpini, R	1
Arslan, G; Dionisotti, S; Fredholm, BB; Kull, B; Ongini, E; Zocchi, C	1
Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U	1
Baraldi, PG; Benini, A; Borea, PA; Cattabriga, E; Gessi, S; Klotz, KN; Lennan, SM; Leung, E; Merighi, S; Tabrizi, MA; Varani, K; Vincenzi, F	1
Bonizzoni, E; Casati, C; Milani, S; Monopoli, A; Ongini, E	1
Casati, C; Conti, A; Cristalli, G; Monopoli, A; Ongini, E; Volpini, R; Zocchi, C	1
Chintala, M; Chiu, PJ; Dionisotti, S; Ongini, E; Sandoli, D	1
Bonizzoni, E; Casati, C; Dionisotti, S; Monopoli, A; Ongini, E; Zocchi, C	1
Busca, G; Castoldi, G; Genovesi, S; Golin, R; Panzacchi, G; Protasoni, G; Stella, A	1
Conti, A; Lozza, G; Monopoli, A	1
Cristalli, G; Morelli, M; Pinna, A; Wardas, J	1
Alberti, C; Casati, C; Forlani, A; Monopoli, A; Morganti, A; Nador, B; Ongini, E; Sala, C	1
Constantino, MD; Cunha, RA; Ribeiro, JA	1
Busca, G; Demarchi, B; Golin, R; Panzacchi, G; Protasoni, G; Stella, A	1
Belardinelli, L; Borea, PA; Merighi, S; Ongini, E; Portaluppi, F; Varani, K	1
Camisasca, P; Genovesi, S; Golin, R; Pieruzzi, F; Protasoni, G; Ragonesi, G; Stella, A; Zanchetti, A	1
Belardinelli, L; Borea, PA; Gessi, S; Merighi, S; Ongini, E; Portaluppi, F; Varani, K	1
Alberti, C; Casati, C; Monopoli, A; Morganti, A; Ongini, E; Sala, C; Zanchetti, A	1
Bonda, TA; Karolczak, K; Kramkowski, K; Polak, D; Przygodzki, T; Talar, M; Watala, C; Wojkowska, DW; Wolska, N	1

Other Studies

24 other study(ies) available for 2-hexynyladenosine-5'-n-ethylcarboxamide and adenosine-5'-(n-ethylcarboxamide)

Article	Year
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. Journal of medicinal chemistry, 1992, Jul-24, Volume: 35, Issue:15 Topics: Adenosine; Animals; Antihypertensive Agents; Brain; Male; Molecular Structure; Rats; Rats, Inbred SHR; Receptors, Purinergic; Substrate Specificity	1992
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. Journal of medicinal chemistry, 1992, Jun-26, Volume: 35, Issue:13 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Binding, Competitive; Blood Platelets; Brain Chemistry; Cell Membrane; Cells, Cultured; Humans; Platelet Aggregation; Radioligand Assay; Rats; Receptors, Purinergic	1992
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. Journal of medicinal chemistry, 1995, Mar-31, Volume: 38, Issue:7 Topics: Adenosine; Animals; Cell Membrane; CHO Cells; Corpus Striatum; Cricetinae; In Vitro Techniques; Magnetic Resonance Spectroscopy; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Recombinant Proteins; Ribose; Structure-Activity Relationship	1995
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. Journal of medicinal chemistry, 1995, Apr-28, Volume: 38, Issue:9 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Male; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1	1995
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. Journal of medicinal chemistry, 1994, May-27, Volume: 37, Issue:11 Topics: Adenosine; Adenosine Diphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Chemical Phenomena; Chemistry, Physical; Heart Rate; Hydroxylation; Male; Molecular Structure; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Structure-Activity Relationship; Vasodilation	1994
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. Journal of medicinal chemistry, 1996, Oct-11, Volume: 39, Issue:21 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Alkylation; Animals; Male; Platelet Aggregation; Rats; Rats, Wistar; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship	1996
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology, 1997, Volume: 121, Issue:3 Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Humans; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Species Specificity; Transfection; Triazoles	1997
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium	1999
Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochemical pharmacology, 2005, Nov-25, Volume: 70, Issue:11 Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Binding, Competitive; Cell Line; Cyclic AMP; Humans; Molecular Structure; Protein Binding; Receptor, Adenosine A2B; Recombinant Proteins	2005
Modeling hemodynamic profiles by telemetry in the rat. A study with A1 and A2a adenosine agonists. Hypertension (Dallas, Tex. : 1979), 1995, Volume: 25, Issue:4 Pt 1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Animals; Hemodynamics; Male; Models, Biological; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Telemetry	1995
Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine. Arzneimittel-Forschung, 1994, Volume: 44, Issue:12 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Cattle; Dose-Response Relationship, Drug; Electroencephalography; Heart; Hemodynamics; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rabbits; Rats; Rats, Sprague-Dawley; Swine	1994
In vivo and ex vivo effects of adenosine A1 and A2 receptor agonists on platelet aggregation in the rabbit. European journal of pharmacology, 1994, Jun-23, Volume: 259, Issue:1 Topics: Adenosine; Adenosine Diphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rabbits	1994
Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Drug Tolerance; Hemodynamics; Male; Phenethylamines; Rats; Rats, Inbred SHR; Receptors, Purinergic P1	1994
Effects of adenosine-receptor agonists on renin release in anaesthetized rats. Journal of hypertension, 1995, Volume: 13, Issue:12 Pt 2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Hemodynamics; Infusions, Intravenous; Kidney; Nerve Fibers; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Renin	1995
Prolonged exposure to 5'-N-ethylcarboxamidoadenosine (NECA) does not affect the adenosine A2A-mediated vasodilation in porcine coronary arteries. Pharmacological research, 1997, Volume: 35, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Dinoprost; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Phenethylamines; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Time Factors; Vasodilation; Vasodilator Agents	1997
Adenosine A2A receptor agonists increase Fos-like immunoreactivity in mesolimbic areas. Brain research, 1997, Jun-06, Volume: 759, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dopamine Agonists; Immunohistochemistry; Limbic System; Male; Oxidopamine; Phenethylamines; Proto-Oncogene Proteins c-fos; Purinergic Antagonists; Purinergic P1 Receptor Agonists; Pyrimidines; Quinpirole; Rats; Rats, Sprague-Dawley; Triazoles	1997
Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists. Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Injections, Intraperitoneal; Male; Phenethylamines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred SHR; Renin; Renin-Angiotensin System	1997
ZM241385 is an antagonist of the facilitatory responses produced by the A2A adenosine receptor agonists CGS21680 and HENECA in the rat hippocampus. British journal of pharmacology, 1997, Volume: 122, Issue:7 Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Binding Sites; Hippocampus; Ligands; Membranes; Phenethylamines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Synaptic Transmission; Synaptosomes; Triazines; Triazoles; Visual Cortex	1997
Effects of adenosine receptor agonists on renal function in anaesthetized rats. Journal of hypertension, 1997, Volume: 15, Issue:12 Pt 2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Denervation; Glomerular Filtration Rate; Hypertension, Renal; Kidney; Male; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Purinergic P1; Receptors, Purinergic P2; Sodium; Urodynamics	1997
Caffeine alters A2A adenosine receptors and their function in human platelets. Circulation, 1999, May-18, Volume: 99, Issue:19 Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Blood Platelets; Caffeine; Cyclic AMP; Female; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P1; Signal Transduction	1999
Effects of adenosine receptor agonists on efferent renal nerve activity in anesthetized rats. Journal of cardiovascular pharmacology, 2000, Volume: 35, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Baroreflex; Blood Pressure; Denervation; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Kidney; Male; Neurons, Efferent; Nitroprusside; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Regression Analysis; Sympathetic Nervous System; Time Factors; Vagotomy	2000
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects. Circulation, 2000, Jul-18, Volume: 102, Issue:3 Topics: Adenosine-5'-(N-ethylcarboxamide); Adult; Blood Platelets; Caffeine; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Myocardium; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Time Factors; Triazoles; Up-Regulation	2000
Humoral effects of selective adenosine agonists in spontaneously hypertensive rats. Journal of hypertension, 1996, Volume: 14, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Heart Rate; Male; Models, Cardiovascular; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred SHR; Renin	1996
Adenosine Receptor Agonist HE-NECA Enhances Antithrombotic Activities of Cangrelor and Prasugrel in vivo by Decreasing of Fibrinogen Density in Thrombus. International journal of molecular sciences, 2021, Mar-17, Volume: 22, Issue:6 Topics: Adenosine Monophosphate; Adenosine-5'-(N-ethylcarboxamide); Adult; Animals; Antithrombins; Blood Pressure; Blood-Brain Barrier; Chlorides; Diastole; Female; Ferric Compounds; Fibrinogen; Humans; Laser-Doppler Flowmetry; Male; Mice, Inbred C57BL; Permeability; Platelet Activation; Platelet Aggregation; Prasugrel Hydrochloride; Purinergic P1 Receptor Agonists; Purinergic P2Y Receptor Antagonists; Systole; Thrombosis	2021