Compounds > 2-heptyl-3-hydroxy-4-quinolone

2-heptyl-3-hydroxy-4-quinolone and 2-aminophenol

2-heptyl-3-hydroxy-4-quinolone has been researched along with 2-aminophenol* in 1 studies

Other Studies

1 other study(ies) available for 2-heptyl-3-hydroxy-4-quinolone and 2-aminophenol

Article	Year
Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer. Chemistry & biology, 2003, Volume: 10, Issue:6 The autoinducer (AI) that initiates the quorum sensing (QS) signaling cascade in Pseudomonas aeruginosa is an acyl-homoserine lactone (acyl-HSL). We initiated a study of the requirements for binding of the AI to its protein effector LasR by synthesizing a library of analogs with the HSL moiety replaced with different amines and alcohols. We tested each compound for both agonist and antagonist activity using a QS-controlled reporter gene assay and found several new agonists and antagonists. A representative antagonist was further tested for its ability to inhibit virulence factors. This data progresses our understanding of the LasR-AI interaction toward the rational design of therapeutic inhibitors of QS. Topics: 4-Butyrolactone; Aminophenols; Bacterial Proteins; Biofilms; DNA-Binding Proteins; Drug Design; Gene Library; Genes, Reporter; Genetic Techniques; Homoserine; Lactones; Molecular Structure; Pseudomonas aeruginosa; Quinolones; Signal Transduction; Structure-Activity Relationship; Trans-Activators; Virulence Factors	2003

Article

Year

Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer.

Chemistry & biology, 2003, Volume: 10, Issue:6

The autoinducer (AI) that initiates the quorum sensing (QS) signaling cascade in Pseudomonas aeruginosa is an acyl-homoserine lactone (acyl-HSL). We initiated a study of the requirements for binding of the AI to its protein effector LasR by synthesizing a library of analogs with the HSL moiety replaced with different amines and alcohols. We tested each compound for both agonist and antagonist activity using a QS-controlled reporter gene assay and found several new agonists and antagonists. A representative antagonist was further tested for its ability to inhibit virulence factors. This data progresses our understanding of the LasR-AI interaction toward the rational design of therapeutic inhibitors of QS.

Topics: 4-Butyrolactone; Aminophenols; Bacterial Proteins; Biofilms; DNA-Binding Proteins; Drug Design; Gene Library; Genes, Reporter; Genetic Techniques; Homoserine; Lactones; Molecular Structure; Pseudomonas aeruginosa; Quinolones; Signal Transduction; Structure-Activity Relationship; Trans-Activators; Virulence Factors

2003