2-ethynylaniline has been researched along with piperidine* in 1 studies
1 other study(ies) available for 2-ethynylaniline and piperidine
| Article | Year |
|---|---|
Copper(I)-catalyzed tandem synthesis of 2-acylquinolines from 2-ethynylanilines and glyoxals.
An efficient one-step synthesis of 2-acylquinolines using a copper-catalyzed tandem reaction of 2-ethynylanilines with glyoxals in the presence of piperidine has been developed. This new protocol successfully avoids multi-step operation and the use of highly toxic cyanides required in traditional methods, and provides a practical tool for synthetic and pharmaceutical chemists. Various 2-acylquinolines are obtained with perfect regioselectivity in moderate to good yields (up to 86%). The potential synthetic utility of this method is exemplified by a large-scale experiment and synthetic transformation of the products. Topics: Acetylene; Aniline Compounds; Catalysis; Copper; Cyclization; Glyoxal; Models, Chemical; Piperidines; Quinolines | 2021 |