2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and paroxetine

2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine has been researched along with paroxetine in 1 studies

Compound Research Comparison

Studies (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine)	Trials (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine)	Recent Studies (post-2010) (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine)	Studies (paroxetine)	Trials (paroxetine)	Recent Studies (post-2010) (paroxetine)
135	6	50	4,257	1,031	1,031

Protein Interaction Comparison

Protein	Taxonomy	paroxetine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	3.9
Myeloperoxidase	Homo sapiens (human)	0.02
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	0.086
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	0.532
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	0.244
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	0.123
Quinolone resistance protein NorA	Staphylococcus aureus	7
Cytochrome P450 2D6	Homo sapiens (human)	0.5003
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	0.145
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	0.179
Beta-adrenergic receptor kinase 1	Bos taurus (cattle)	1.08
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	0.093
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	0.623
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	1.24
Substance-P receptor	Homo sapiens (human)	0.9
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.0007
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.0003
P2X purinoceptor 4	Rattus norvegicus (Norway rat)	2.45
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	3.9
Sodium-dependent dopamine transporter	Homo sapiens (human)	0.672
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	3.9
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	3.9
P2X purinoceptor 4	Homo sapiens (human)	2.8067
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	5.366
Transporter	Rattus norvegicus (Norway rat)	0.535

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
DeVane, CL; Wang, JS	1

Other Studies

1 other study(ies) available for 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and paroxetine

Article	Year
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Methadone; Microsomes, Liver; Paroxetine; Pyrrolidines; Recombinant Proteins; Stereoisomerism; Trimethoprim	2003

Article

Year

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.

Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6

Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; In Vitro Techniques; Isoenzymes; Ketoconazole; Methadone; Microsomes, Liver; Paroxetine; Pyrrolidines; Recombinant Proteins; Stereoisomerism; Trimethoprim

2003