2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine has been researched along with amitriptyline in 4 studies
| Studies (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) | Trials (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) | Recent Studies (post-2010) (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine) | Studies (amitriptyline) | Trials (amitriptyline) | Recent Studies (post-2010) (amitriptyline) |
|---|---|---|---|---|---|
| 135 | 6 | 50 | 6,935 | 1,381 | 1,060 |
| Protein | Taxonomy | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (IC50) | amitriptyline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.006 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.023 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.081 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0053 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.3 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.044 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.008 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.1755 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.011 | |
| D(2) dopamine receptor | Homo sapiens (human) | 1.009 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.044 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.004 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0295 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 1.02 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.026 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.355 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.0324 | |
| Histamine H2 receptor | Homo sapiens (human) | 0.73 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.105 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.015 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.006 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 1.02 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.044 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.2756 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.044 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0048 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.182 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.07 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.66 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.14 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 7.2446 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 1.6 | |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | 4 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.044 | |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | 3.1 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.031 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.044 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Bomsien, S; Skopp, G | 1 |
| Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT | 1 |
| Chatterton, C; Cirimele, V; Duez, M; Etter, M; Klinger, N; Turner, K | 1 |
4 other study(ies) available for 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and amitriptyline
| Article | Year |
|---|---|
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
An in vitro approach to potential methadone metabolic-inhibition interactions.
Topics: Algorithms; Amitriptyline; Analgesics, Opioid; Atomoxetine Hydrochloride; Chromatography, Liquid; Citalopram; Clozapine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Isoenzymes; Kinetics; Methadone; Methylation; N-Methyl-3,4-methylenedioxyamphetamine; Oxidoreductases, N-Demethylating; Propylamines; Psychotropic Drugs; Pyridines; Pyrrolidines; Tandem Mass Spectrometry; Zolpidem | 2007 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Heroin Dependence; Humans; Linkage Disequilibrium; Male; Methadone; Middle Aged; Morphine; Polymorphism, Single Nucleotide; Pyrrolidines; Substance Withdrawal Syndrome; Taiwan | 2012 |
Interpretation of pharmaceutical drug concentrations in young children's head hair.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Child; Child of Impaired Parents; Child, Preschool; Chromatography, Liquid; Female; Forensic Toxicology; Hair; Humans; Infant; Methadone; Narcotics; Nortriptyline; Pyrrolidines; Substance Abuse Detection; Tandem Mass Spectrometry; Tramadol | 2014 |