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2-ethyl-2-methyl-4-butyrolactone and alpha-isopropyl-alpha-methyl-gamma-butyrolactone

2-ethyl-2-methyl-4-butyrolactone has been researched along with alpha-isopropyl-alpha-methyl-gamma-butyrolactone in 4 studies

Compound Research Comparison

Studies
(2-ethyl-2-methyl-4-butyrolactone)
Trials
(2-ethyl-2-methyl-4-butyrolactone)
Recent Studies (post-2010)
(2-ethyl-2-methyl-4-butyrolactone)
Studies
(alpha-isopropyl-alpha-methyl-gamma-butyrolactone)
Trials
(alpha-isopropyl-alpha-methyl-gamma-butyrolactone)
Recent Studies (post-2010) (alpha-isopropyl-alpha-methyl-gamma-butyrolactone)
900500

Protein Interaction Comparison

ProteinTaxonomy2-ethyl-2-methyl-4-butyrolactone (IC50)alpha-isopropyl-alpha-methyl-gamma-butyrolactone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.74
GABA theta subunitRattus norvegicus (Norway rat)0.74
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.74

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Canney, DJ; Covey, DF; Ferrendelli, JA; Holland, KD; Levine, JA; McKeon, AC1
Covey, DF; Ferrendelli, JA; Holland, KD; McKeon, AC; Peterson, EM; Rothman, SM; Xu, K1
Covey, DF; Ferrendelli, JA; Holland, KD; Rothman, SM; Yoon, KW1
Covey, DF; Rothman, SM; Yoon, KW1

Other Studies

4 other study(ies) available for 2-ethyl-2-methyl-4-butyrolactone and alpha-isopropyl-alpha-methyl-gamma-butyrolactone

ArticleYear
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:4

    Topics: 4-Butyrolactone; Alkylation; Animals; Anticonvulsants; Brain; Convulsants; Female; Ligands; Mice; Mice, Inbred Strains; Molecular Structure; Neurotoxins; Picrotoxin; Receptors, GABA-A; Seizures; Structure-Activity Relationship

1991
Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.
    Journal of medicinal chemistry, 1994, Jan-21, Volume: 37, Issue:2

    Topics: 4-Butyrolactone; Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Convulsants; Female; Hippocampus; Mice; Models, Molecular; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Spiro Compounds; Structure-Activity Relationship

1994
Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.
    Molecular pharmacology, 1991, Volume: 39, Issue:1

    Topics: 4-Butyrolactone; Animals; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Membrane Potentials; Rats; Receptors, GABA-A

1991
Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons.
    The Journal of physiology, 1993, Volume: 464

    Topics: 4-Butyrolactone; Animals; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Hippocampus; Neurons; Picrotoxin; Rats; Reaction Time

1993