Page last updated: 2024-09-04

2-diphenylmethylpiperidine and cyproheptadine

2-diphenylmethylpiperidine has been researched along with cyproheptadine in 2 studies

*Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [MeSH]

*Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [MeSH]

Compound Research Comparison

Studies
(2-diphenylmethylpiperidine)
Trials
(2-diphenylmethylpiperidine)
Recent Studies (post-2010)
(2-diphenylmethylpiperidine)
Studies
(cyproheptadine)
Trials
(cyproheptadine)
Recent Studies (post-2010) (cyproheptadine)
7052,297262201

Protein Interaction Comparison

ProteinTaxonomy2-diphenylmethylpiperidine (IC50)cyproheptadine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.0024
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.564
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.035
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.016
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0031
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.0038
Alpha-2A adrenergic receptorHomo sapiens (human)0.283
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.016
D(2) dopamine receptorHomo sapiens (human)0.164
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0031
Alpha-2B adrenergic receptorHomo sapiens (human)0.038
Alpha-2C adrenergic receptorHomo sapiens (human)1.275
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.122
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.046
D(1A) dopamine receptorHomo sapiens (human)0.158
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.564
Histamine H2 receptorHomo sapiens (human)0.198
Alpha-1D adrenergic receptorHomo sapiens (human)0.107
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.001
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0024
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.122
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0031
Histamine H1 receptorHomo sapiens (human)0.0037
D(3) dopamine receptorHomo sapiens (human)0.048
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.0094
5-hydroxytryptamine receptor 6Homo sapiens (human)0.281
D(2) dopamine receptorRattus norvegicus (Norway rat)0.14
Histone-lysine N-methyltransferase SETD7Homo sapiens (human)2.2

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fischer, LJ; Miller, CP; Reape, TJ1
Fischer, LJ; Hawkins, BS1

Other Studies

2 other study(ies) available for 2-diphenylmethylpiperidine and cyproheptadine

ArticleYear
Inhibition of insulin production by cyproheptadine in RINm5F rat insulinoma cells.
    Journal of biochemical toxicology, 1993, Volume: 8, Issue:3

    Topics: Animals; Blotting, Northern; Cyproheptadine; DNA; Indicators and Reagents; Insulin; Insulinoma; Pancreatic Neoplasms; Piperidines; Rats; RNA, Messenger; Tumor Cells, Cultured

1993
Inhibition of insulin synthesis by cyproheptadine: effects on translation.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 79, Issue:2

    Topics: Animals; Cell Fractionation; Cell Line, Tumor; Cyproheptadine; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4E; Insulin; Insulin Antagonists; Phosphorylation; Piperidines; Proinsulin; Protein Biosynthesis; Protein Precursors; Rats; RNA, Messenger; Time Factors

2004