Compounds > 2-deoxystreptamine
Page last updated: 2024-09-05

2-deoxystreptamine and framycetin

2-deoxystreptamine has been researched along with framycetin in 14 studies

Compound Research Comparison

Studies
(2-deoxystreptamine)		Trials
(2-deoxystreptamine)		Recent Studies (post-2010)
(2-deoxystreptamine)		Studies
(framycetin)		Trials
(framycetin)		Recent Studies (post-2010) (framycetin)
860188,151460653

Protein Interaction Comparison

ProteinTaxonomy2-deoxystreptamine (IC50)framycetin (IC50)
30S ribosomal protein S6Escherichia coli K-120.032
30S ribosomal protein S7Escherichia coli K-120.032
50S ribosomal protein L15Escherichia coli K-120.032
50S ribosomal protein L10Escherichia coli K-120.032
50S ribosomal protein L11Escherichia coli K-120.032
50S ribosomal protein L7/L12Escherichia coli K-120.032
50S ribosomal protein L19Escherichia coli K-120.032
50S ribosomal protein L1Escherichia coli K-120.032
50S ribosomal protein L20Escherichia coli K-120.032
50S ribosomal protein L27Escherichia coli K-120.032
50S ribosomal protein L28Escherichia coli K-120.032
50S ribosomal protein L29Escherichia coli K-120.032
50S ribosomal protein L31Escherichia coli K-120.032
50S ribosomal protein L31 type BEscherichia coli K-120.032
50S ribosomal protein L32Escherichia coli K-120.032
50S ribosomal protein L33Escherichia coli K-120.032
50S ribosomal protein L34Escherichia coli K-120.032
50S ribosomal protein L35Escherichia coli K-120.032
50S ribosomal protein L36Escherichia coli K-120.032
30S ribosomal protein S10Escherichia coli K-120.032
30S ribosomal protein S11Escherichia coli K-120.032
30S ribosomal protein S12Escherichia coli K-120.032
30S ribosomal protein S13Escherichia coli K-120.032
30S ribosomal protein S16Escherichia coli K-120.032
30S ribosomal protein S18Escherichia coli K-120.032
30S ribosomal protein S19Escherichia coli K-120.032
30S ribosomal protein S20Escherichia coli K-120.032
30S ribosomal protein S2Escherichia coli K-120.032
30S ribosomal protein S3Escherichia coli K-120.032
30S ribosomal protein S4Escherichia coli K-120.032
30S ribosomal protein S5Escherichia coli K-120.032
30S ribosomal protein S8Escherichia coli K-120.032
30S ribosomal protein S9Escherichia coli K-120.032
50S ribosomal protein L13Escherichia coli K-120.032
50S ribosomal protein L14Escherichia coli K-120.032
50S ribosomal protein L16Escherichia coli K-120.032
50S ribosomal protein L23Escherichia coli K-120.032
30S ribosomal protein S15Escherichia coli K-120.032
50S ribosomal protein L17Escherichia coli K-120.032
50S ribosomal protein L21Escherichia coli K-120.032
50S ribosomal protein L30Escherichia coli K-120.032
50S ribosomal protein L6Escherichia coli K-120.032
30S ribosomal protein S14Escherichia coli K-120.032
30S ribosomal protein S17Escherichia coli K-120.032
30S ribosomal protein S1Escherichia coli K-120.032
50S ribosomal protein L18Escherichia coli K-120.032
50S ribosomal protein L2Escherichia coli K-120.032
50S ribosomal protein L3Escherichia coli K-120.032
50S ribosomal protein L24Escherichia coli K-120.032
50S ribosomal protein L4Escherichia coli K-120.032
50S ribosomal protein L22Escherichia coli K-120.032
50S ribosomal protein L5Escherichia coli K-120.032
30S ribosomal protein S21Escherichia coli K-120.032
50S ribosomal protein L25Escherichia coli K-120.032
50S ribosomal protein L36 2Escherichia coli K-120.032

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's5 (35.71)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Alborn, WE; Allen, NE; Kirst, HA; Toth, JE1
Constantinou-Kokotou, T; Karikas, G; Kokotos, G1
Carvalho, I; Corrado, AP; da Silva, JG; de Oliveira, JA; Hyppolito, MA; Ito, IY1
Aboul-ela, F; Allam, K; Bodoor, K; Boisdore, M; Boyapati, V; Gopu, V; Miller, J; Treleaven, WD; Weldeghiorghis, T1
Haydock, SF; Huang, F; Li, Y; Mironenko, T; Spencer, JB; Spiteller, D1
Blaauw, RH; Gruijters, BW; Rutjes, FP; van Delft, FL; van den Broek, SB1
Fan, Q; Huang, F; Leadlay, PF; Spencer, JB1
Pang, LJ; Wang, D; Ye, XS; Zhang, LH; Zhou, J1
Chittapragada, M; Dayton, DL; Ham, YW; Marble, JB; Udumula, V1
Ban, YH; Park, JW; Park, SR; Sohng, JK; Yoon, YJ1
Carvalho, I; Corrado, AP; Prado, WA; Rossaneis, AC; Zamoner, LO1
Borovika, A; Khomutnyk, Y; Lee, J; Nagorny, P1
Böttger, EC; Crich, D; Furukawa, T; Hobbie, SN; Mantovani, M; Mondal, S; Sarpe, VA; Sati, GC; Vasella, A1
Crich, D; Sonousi, A; Vasella, A1

Reviews

1 review(s) available for 2-deoxystreptamine and framycetin

ArticleYear
2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways.
    Natural product reports, 2013, Volume: 30, Issue:1

    Topics: Aminoglycosides; Anti-Bacterial Agents; Biosynthetic Pathways; Gentamicins; Hexosamines; Kanamycin; Molecular Structure; Neomycin

2013

Other Studies

13 other study(ies) available for 2-deoxystreptamine and framycetin

ArticleYear
Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Aminoglycosides; Anti-Bacterial Agents; Biological Transport; Escherichia coli; Indicators and Reagents; Kinetics; Structure-Activity Relationship

1987
Study of aminoglycoside-nucleic acid interactions by an HPLC method.
    Bioorganic & medicinal chemistry letters, 2001, Apr-23, Volume: 11, Issue:8

    Topics: Anti-Bacterial Agents; Binding Sites; Chromatography, High Pressure Liquid; DNA; Framycetin; Kanamycin; Neomycin; Netilmicin; RNA, Transfer

2001
Aminoglycoside antibiotic derivatives: preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity.
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacteria; Cochlea; Guinea Pigs; Microscopy, Electron, Scanning; Structure-Activity Relationship; Vestibule, Labyrinth

2007
Design and implementation of an ribonucleic acid (RNA) directed fragment library.
    Journal of medicinal chemistry, 2009, Jun-25, Volume: 52, Issue:12

    Topics: Binding Sites; Chemistry, Physical; Databases, Factual; Drug Design; Ligands; Magnetic Resonance Spectroscopy; Molecular Weight; Organic Chemicals; Quality Control; RNA; Small Molecule Libraries

2009
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.
    Organic & biomolecular chemistry, 2005, Apr-21, Volume: 3, Issue:8

    Topics: Amination; Carbohydrate Conformation; Chromatography, Liquid; Cloning, Molecular; Hexosamines; Multigene Family; Neomycin; Open Reading Frames; Ribose; Spectrum Analysis; Streptomyces; Transaminases

2005
A short and scalable route to orthogonally O-protected 2-deoxystreptamine.
    The Journal of organic chemistry, 2007, Apr-27, Volume: 72, Issue:9

    Topics: Chemistry, Organic; Hexosamines; Hydrolysis; Magnetic Resonance Spectroscopy; Neomycin

2007
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.
    Organic & biomolecular chemistry, 2008, Sep-21, Volume: 6, Issue:18

    Topics: Acetylglucosamine; Amidohydrolases; Amino Acid Sequence; Conserved Sequence; Glycosyltransferases; Hexosamines; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multigene Family; Neomycin; Sequence Alignment; Streptomyces

2008
Synthesis of neamine-derived pseudodisaccharides by stereo- and regio-selective functional group transformations.
    Organic & biomolecular chemistry, 2009, Oct-21, Volume: 7, Issue:20

    Topics: Anti-Bacterial Agents; Biomimetics; Disaccharides; Framycetin; Glycosylation; Hexosamines; Pseudomonas aeruginosa; RNA; Stereoisomerism; Substrate Specificity

2009
Conjugate of neamine and 2-deoxystreptamine mimic connected by an amide bond.
    Bioorganic & medicinal chemistry letters, 2011, Aug-15, Volume: 21, Issue:16

    Topics: Amides; Carboxylic Acids; Framycetin; Hexosamines; Molecular Conformation; Molecular Mimicry; RNA; Stereoisomerism

2011
Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain.
    The Journal of pharmacy and pharmacology, 2015, Volume: 67, Issue:12

    Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Framycetin; Hexosamines; Injections, Spinal; Male; Molecular Structure; Neuralgia; Nociception; Nociceptive Pain; Pain Measurement; Pain Threshold; Pain, Postoperative; Rats, Wistar; Reaction Time; Structure-Activity Relationship; Time Factors

2015
Chiral phosphoric acid-catalyzed desymmetrizative glycosylation of 2-deoxystreptamine and its application to aminoglycoside synthesis.
    Chemical communications (Cambridge, England), 2017, Aug-08, Volume: 53, Issue:64

    Topics: Aminoglycosides; Catalysis; Framycetin; Glycosylation; Hexosamines; Kanamycin; Phosphoric Acids; Stereoisomerism

2017
Modification at the 2'-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity.
    ACS infectious diseases, 2019, 10-11, Volume: 5, Issue:10

    Topics: Aminoglycosides; Anti-Bacterial Agents; Bacteria; Binding Sites; Drug Resistance, Multiple, Bacterial; Hexosamines; Humans; Microbial Sensitivity Tests; Neomycin; Paromomycin; Protein Biosynthesis; Ribosomes; Structure-Activity Relationship

2019
Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5-2-Deoxystreptamine Type Aminoglycoside Antibiotics.
    The Journal of organic chemistry, 2020, 06-05, Volume: 85, Issue:11

    Topics: Aminoglycosides; Anti-Bacterial Agents; Hexosamines; Neomycin; Paromomycin

2020