Page last updated: 2024-08-20

2-chloroadenosine and cladribine

2-chloroadenosine has been researched along with cladribine in 52 studies

Research

Studies (52)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (11.54)	18.7374
1990's	37 (71.15)	18.2507
2000's	7 (13.46)	29.6817
2010's	2 (3.85)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Clayton, SD; Montgomery, JA; Riordan, JM; Secrist, JA; Shortnacy-Fowler, AT	1
Cristalli, G; Esker, JL; Jacobson, KA; Ji, XD; Melman, N; Olah, ME; Schneller, SW; Secrist, JA; Siddiqi, SM; Tiwari, KN	1
Barbieri, D; Camaioni, E; Costanzi, S; Cristalli, G; Franceschi, C; Vittori, S; Volpini, R	1
Abdelrahman, A; Alksnis, E; Borrmann, T; Cristalli, G; Gorzalka, S; Knospe, M; Lambertucci, C; Müller, CE; Schiedel, AC; Volpini, R	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Huang, Y; Li, J; Luo, HB; Mao, F; Qiu, X; Wu, D; Yan, W; Zhu, J	1
Piro, LD	1
Beran, M; Estey, EH; Hirsch-Ginsberg, C; Huh, YO; Kantarjian, HM; Keating, MJ; Koller, C; Kurzrock, R; McCredie, KB; O'Brien, SM	1
Juliusson, G; Liliemark, J	3
Cheson, BD	3
Blakley, RL; Crom, W; Kearns, C; Mirro, J; Santana, VM; Schell, MJ	1
Beutler, E; Carrera, CJ; Carson, DA; Kay, AC; Piro, LD; Saven, A; Thurston, D	1
Hagberg, H	1
Carrera, CJ; Carson, DA; Cottam, HB; Esparza, LM; Kipps, TJ; Wasson, DB	1
Nightingale, SL	1
Daly, K; Golomb, HM; Mick, R; Ratain, MJ	1
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD; Saven, A	1
Alexanian, R; Dimopoulos, MA; Estey, EH; Kantarjian, HM	1
Elmhorn-Rosenborg, A; Juliusson, G; Liliemark, J	1
Belt, J; Brenner, MK; Crom, W; Hurwitz, CA; Krance, R; Mahmoud, H; Ribeirio, R; Roberts, WM; Santana, VM; Schell, MJ	1
Arizono, K; Brady, FO; Garrett, SH; Xiong, X	1
Blakley, RL; Cherrie, J; Harwood, FC; Kalwinsky, D; Mirro, J; Santana, VM; Schell, M	1
Plunkett, W; Saunders, PP	1
Gribbin, TE	1
Hiraoka, W; Kuwabara, M; Matsuda, A; Sato, F; Tamura, Y; Tanabe, K; Ueda, T	1
Juliusson, G; Liliemark, J; Pettersson, B	1
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD; Saven, A; Terai, C	1
Blatt, LM; Ozes, ON; Reiter, Z; Taylor, MW; Tomson, S	1
Bilgeri, R; Braunsteiner, H; Geisen, FH; Haun, M; Konwalinka, G; Petzer, AL; Pragnell, I; Zilian, U	1
Beutler, E; Carrera, CJ; Carson, DA; Curd, JG; Lotz, M; Piro, LD; Terai, C	1
Golde, DW; Lill, MC	1
Gutterman, JU; Kurzrock, R; Talpaz, M	1
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD	1
Belt, JA; Crawford, CR; Ng, CY	1
Blakley, RL; Griffig, J; Koob, R	1
Hiraoka, W; Kuwabara, M; Matsuda, A; Sato, F; Tanabe, K; Ueda, T	1
Hiramoto-Yoshioka, A; Watanabe, K; Wataya, Y; Yoshida, S	1
Carrera, CJ; Carson, DA; Lotz, M; Piro, LD; Yamanaka, H	1
Hiramoto-Yoshioka, A; Hirota, Y; Matsuda, A; Minowada, J; Otani, T; Tanaka, S; Ueda, T; Wataya, Y	1
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD; Wasson, DB	1
Szondy, Z	1
Bloński, JZ; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Grieb, P; Hansz, J; Hellmann, A; Holowiecki, J; Kasznicki, M; Komarnicki, M; Konopka, L; Kroll, R; Kuliczkowski, K; Lewandowski, K; Nowak, W; Potoczek, S; Robak, T; Skotnicki, AB; Soroka-Wojtaszko, M; Tomaszewska, A; Zdziarska, B	1
Abbracchio, MP; Ambrosini, A; Barbieri, D; Camurri, A; Cattabeni, F; Ceruti, S; Franceschi, C; Giammarioli, AM; Malorni, W; Racagni, G	1
Abdel-Hamid, M; Hamza, H; Novotny, L	1
Abbracchio, MP; Beltrami, E; Cattabeni, F; Ceruti, S; Malorni, W; Matarrese, P; Mazzola, A	1
Liang, NC; Liu, XG; Zhu, F	1
Bellezza, I; Conte, C; Culig, Z; Minelli, A; Rambotti, MG; Tucci, A	1

Reviews

6 review(s) available for 2-chloroadenosine and cladribine

Article	Year
The treatment of hairy cell leukemia: an update. Leukemia, 1992, Volume: 6 Suppl 2 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Interferon-alpha; Leukemia, Hairy Cell; Pentostatin; Splenectomy	1992
Metabolism and action of purine nucleoside analogs. Pharmacology & therapeutics, 1991, Volume: 49, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Cladribine; Deoxyadenosines; Guanine; Guanosine; Humans; Purine Nucleosides; Ribavirin; Vidarabine	1991
New purine analogues for the treatment of chronic B-cell malignancies. Henry Ford Hospital medical journal, 1991, Volume: 39, Issue:2 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Vidarabine	1991
Treatment of hairy-cell leukemia. Blood reviews, 1990, Volume: 4, Issue:4 Topics: 2-Chloroadenosine; Antibody Formation; Antineoplastic Agents; Cladribine; Combined Modality Therapy; Deoxyadenosines; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Deficiency Syndromes; Immunologic Factors; Interferon Type I; Leukemia, Hairy Cell; Pentostatin; Remission Induction; Retrospective Studies; Splenectomy	1990
Hairy cell leukaemia: review of treatment. British journal of haematology, 1991, Volume: 79 Suppl 1 Topics: 2-Chloroadenosine; Cladribine; Deoxyadenosines; Granulocyte Colony-Stimulating Factor; Humans; Interferon-alpha; Leukemia, Hairy Cell; Pentostatin; Splenectomy	1991
Activity of 2-chloro-2'-deoxyadenosine in chronic lymphocytic leukemia, hairy cell leukemia, and autoimmune hemolytic anemia. Advances in experimental medicine and biology, 1989, Volume: 253A Topics: 2-Chloroadenosine; Adenosine Deaminase; Anemia, Hemolytic, Autoimmune; Cladribine; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell	1989

Trials

7 trial(s) available for 2-chloroadenosine and cladribine

Article	Year
2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:3 Topics: 2-Chloroadenosine; Acute Disease; Adolescent; Adult; Antineoplastic Agents; Bone Marrow Transplantation; Child; Child, Preschool; Cladribine; Combined Modality Therapy; Deoxyadenosines; Drug Evaluation; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Remission Induction	1992
2-Chlorodeoxyadenosine treatment of low-grade lymphomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:3 Topics: 2-Chloroadenosine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bacterial Infections; Bone Marrow Diseases; Cladribine; Deoxyadenosines; Drug Evaluation; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Male; Middle Aged; Remission Induction; Treatment Outcome	1992
Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. The New England journal of medicine, 1992, Oct-08, Volume: 327, Issue:15 Topics: 2-Chloroadenosine; Adult; Antineoplastic Agents; Cladribine; Deoxyadenosines; Drug Resistance; Female; Haptoglobins; Humans; Immunoglobulins; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Lymphocytes; Male; Middle Aged; Remission Induction; Vidarabine	1992
Current strategies for treatment of acute myeloid leukemia at St Jude Children's Research Hospital. Leukemia, 1992, Volume: 6 Suppl 2 Topics: 2-Chloroadenosine; Acute Disease; Adolescent; Adult; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Child; Child, Preschool; Cladribine; Cytarabine; Daunorubicin; Deoxyadenosines; Etoposide; Humans; Infant; Leukemia, Myeloid, Acute; Remission Induction	1992
A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:3 Topics: 2-Chloroadenosine; Adolescent; Adult; Child; Child, Preschool; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Infant; Infusions, Intravenous; Leukemia, Myeloid; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma	1991
Treatment of hairy-cell leukemia. Blood reviews, 1990, Volume: 4, Issue:4 Topics: 2-Chloroadenosine; Antibody Formation; Antineoplastic Agents; Cladribine; Combined Modality Therapy; Deoxyadenosines; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Deficiency Syndromes; Immunologic Factors; Interferon Type I; Leukemia, Hairy Cell; Pentostatin; Remission Induction; Retrospective Studies; Splenectomy	1990
Cladribine with or without prednisone in the treatment of previously treated and untreated B-cell chronic lymphocytic leukaemia - updated results of the multicentre study of 378 patients. British journal of haematology, 2000, Volume: 108, Issue:2 Topics: 2-Chloroadenosine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Deoxyadenosines; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Prospective Studies; Survival Analysis	2000

Other Studies

40 other study(ies) available for 2-chloroadenosine and cladribine

Article	Year
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine. Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2 Topics: Animals; Antimetabolites, Antineoplastic; Escherichia coli; HIV; Humans; Leukemia P388; Mice; Purine-Nucleoside Phosphorylase; Structure-Activity Relationship; Tumor Cells, Cultured; Vidarabine	1992
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. Journal of medicinal chemistry, 1995, Mar-31, Volume: 38, Issue:7 Topics: Adenosine; Animals; Cell Membrane; CHO Cells; Corpus Striatum; Cricetinae; In Vitro Techniques; Magnetic Resonance Spectroscopy; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Recombinant Proteins; Ribose; Structure-Activity Relationship	1995
Modulation of apoptosis in human lymphocytes by adenosine analogues. Bioorganic & medicinal chemistry letters, 1998, Sep-22, Volume: 8, Issue:18 Topics: 2-Chloroadenosine; Apoptosis; Cells, Cultured; Deoxyadenosines; Flow Cytometry; Humans; Lymphocytes; Models, Chemical; Propidium; Structure-Activity Relationship	1998
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Adenine; Animals; Astrocytoma; Cell Line; Cell Line, Tumor; Cerebral Cortex; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Tubercidin	2009
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Discovery of novel purine nucleoside derivatives as phosphodiesterase 2 (PDE2) inhibitors: Structure-based virtual screening, optimization and biological evaluation. Bioorganic & medicinal chemistry, 2018, 01-01, Volume: 26, Issue:1 Topics: Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Humans; Models, Molecular; Molecular Structure; Nucleosides; Phosphodiesterase Inhibitors; Purines; Structure-Activity Relationship	2018
2-Chlorodeoxyadenosine treatment of lymphoid malignancies. Blood, 1992, Feb-15, Volume: 79, Issue:4 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Lymphoma	1992
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA). Blood, 1992, Feb-15, Volume: 79, Issue:4 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Drug Resistance; Humans; Leukemia, Hairy Cell; Leukocyte Count; Leukopenia; Male; Middle Aged; Neutrophils; Platelet Count; Remission Induction; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory	1992
Rapid recovery from cytopenia in hairy cell leukemia after treatment with 2-chloro-2'-deoxyadenosine (CdA): relation to opportunistic infections. Blood, 1992, Feb-15, Volume: 79, Issue:4 Topics: 2-Chloroadenosine; Antineoplastic Agents; Candidiasis; Cladribine; Cytomegalovirus Infections; Deoxyadenosines; Humans; Immunophenotyping; Leukemia, Hairy Cell; Leukopenia; Lymphocytes; Monocytes; Neutrophils; Opportunistic Infections; Remission Induction; Thrombocytopenia	1992
The purine analogs--a therapeutic beauty contest. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:3 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Lymphoma, Non-Hodgkin; Pentostatin; Vidarabine	1992
[Alpha interferon treatment in hairy cell leukemia]. Nordisk medicin, 1992, Volume: 107, Issue:3 Topics: 2-Chloroadenosine; Cladribine; Deoxyadenosines; Drug Therapy, Combination; Humans; Interferon-alpha; Leukemia, Hairy Cell; Pentostatin	1992
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proceedings of the National Academy of Sciences of the United States of America, 1992, Apr-01, Volume: 89, Issue:7 Topics: 2-Chloroadenosine; Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Death; Cladribine; Clofarabine; Deoxyadenosines; DNA; DNA Damage; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mice; Mice, SCID; Monocytes	1992
The purine analogs--a therapeutic beauty contest. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:5 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Pentostatin; Vidarabine	1992
From the Food and Drug Administration. JAMA, 1992, May-13, Volume: 267, Issue:18 Topics: 2-Chloroadenosine; Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Agents; Antitubercular Agents; Cladribine; Deoxyadenosines; Drugs, Investigational; Equipment and Supplies; Fetus; Humans; Leukemia, Hairy Cell; Mycobacterium avium-intracellulare Infection; Product Surveillance, Postmarketing; Rifabutin; Rifamycins; United States; United States Food and Drug Administration	1992
Clinical trials referral resource. Clinical trials with 2-chlorodeoxyadenosine. Oncology (Williston Park, N.Y.), 1992, Volume: 6, Issue:5 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Neoplasms	1992
2-Chlorodeoxyadenosine: an active agent in the treatment of cutaneous T-cell lymphoma. Blood, 1992, Aug-01, Volume: 80, Issue:3 Topics: 2-Chloroadenosine; Aged; Aged, 80 and over; Antigens, CD; Antineoplastic Agents; Cladribine; Deoxyadenosines; Female; Follow-Up Studies; Humans; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Neoplasm Staging; Skin Neoplasms; Time Factors	1992
Pentostatin and 2-chlorodeoxyadenosine for hairy-cell leukemia. The Medical letter on drugs and therapeutics, 1992, Sep-18, Volume: 34, Issue:879 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Pentostatin; Vidarabine	1992
2-Chlorodeoxyadenosine in the treatment of multiple myeloma. Blood, 1992, Sep-15, Volume: 80, Issue:6 Topics: 2-Chloroadenosine; Adult; Aged; Antineoplastic Agents; Cladribine; Deoxyadenosines; Female; Humans; Male; Middle Aged; Multiple Myeloma	1992
Purinergic agonist induction of metallothionein. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 201, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cells, Cultured; Cladribine; Deoxyadenosines; Dose-Response Relationship, Drug; Immunoblotting; Liver; Male; Metallothionein; Rats; Rats, Inbred Strains; RNA, Messenger; Theophylline; Time Factors; Transcription, Genetic; Vasodilator Agents	1992
[A new effective therapy of hairy cell leukemia and other lymphoproliferative diseases]. Lakartidningen, 1991, Aug-28, Volume: 88, Issue:35 Topics: 2-Chloroadenosine; Cladribine; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Lymphoproliferative Disorders	1991
On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans. Cancer research, 1991, Oct-15, Volume: 51, Issue:20 Topics: 2-Chloroadenosine; Chromatography, High Pressure Liquid; Cladribine; Deoxyadenosines; Humans; Leukemia	1991
2-Chlorodeoxyadenosine inhibits the repair of DNA double-strand breaks and does not inhibit the repair of DNA single-strand breaks in X-irradiated Chinese hamster V79 cells. Chemico-biological interactions, 1991, Volume: 79, Issue:3 Topics: 2-Chloroadenosine; Animals; Cell Line; Cell Survival; Cladribine; Cricetinae; Cricetulus; Deoxyadenosines; DNA; DNA Damage; DNA Repair; DNA, Single-Stranded; Dose-Response Relationship, Drug; X-Rays	1991
Determination of 2-chloro-2'-deoxyadenosine in human plasma. Biomedical chromatography : BMC, 1991, Volume: 5, Issue:6 Topics: 2-Chloroadenosine; Aged; Chromatography, High Pressure Liquid; Cladribine; Deoxyadenosines; Humans; Lymphoma, T-Cell, Cutaneous; Male	1991
2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: 2-Chloroadenosine; Cell Death; Cladribine; Deoxyadenosines; DNA; DNA Damage; Humans; In Vitro Techniques; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Nucleosomes; Reference Values	1991
A dual anti-tumor effect of a combination of interferon-alpha and 5-flurouracil or 2-chlorodeoxyadenosine on natural killer (NK) cell mediated cytotoxicity. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: 2-Chloroadenosine; Acquired Immunodeficiency Syndrome; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Cladribine; Cytotoxicity, Immunologic; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorouracil; Humans; Interferon Type I; Killer Cells, Natural; Kinetics; Leukemia, Hairy Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Recombinant Proteins; Sarcoma, Kaposi; Uterine Cervical Neoplasms	1991
Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid, and T-lymphocytic colony growth. Blood, 1991, Nov-15, Volume: 78, Issue:10 Topics: 2-Chloroadenosine; Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cells, Cultured; Cladribine; Clone Cells; Colony-Forming Units Assay; Deoxyadenosines; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Granulocytes; Hematopoietic Stem Cells; Humans; T-Lymphocytes; Time Factors	1991
Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. The Journal of clinical investigation, 1990, Volume: 86, Issue:5 Topics: 2-Chloroadenosine; Adenosine Triphosphate; Cell Survival; Cells, Cultured; Cladribine; Deoxyadenosines; DNA Damage; Humans; Interleukin-6; Lymphoma, T-Cell; Monocytes; Mutagens; NAD; Phagocytosis; Protein Biosynthesis; RNA; Time Factors	1990
Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. The New England journal of medicine, 1990, Apr-19, Volume: 322, Issue:16 Topics: 2-Chloroadenosine; Adult; Antineoplastic Agents; Bone Marrow; Cladribine; Deoxyadenosines; Female; Humans; Infusions, Parenteral; Leukemia, Hairy Cell; Male; Middle Aged; Remission Induction	1990
Isolation and characterization of an L1210 cell line retaining the sodium-dependent carrier cif as its sole nucleoside transport activity. The Journal of biological chemistry, 1990, Aug-15, Volume: 265, Issue:23 Topics: 2-Chloroadenosine; Affinity Labels; Animals; Carrier Proteins; Cell Division; Cell Membrane; Cell Survival; Cladribine; Deoxyadenosines; Kinetics; Leukemia L1210; Membrane Transport Proteins; Methotrexate; Mice; Mutation; Nucleosides; Sodium; Thioinosine; Thymidine; Tumor Cells, Cultured	1990
Mechanisms of inhibition of DNA synthesis by 2-chlorodeoxyadenosine in human lymphoblastic cells. Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1 Topics: 2-Chloroadenosine; Chromatography, High Pressure Liquid; Cladribine; Deoxyadenosines; DNA Replication; DNA, Neoplasm; Humans; Leukemia, Lymphoid; Ribonucleotides; Tumor Cells, Cultured	1989
Induction of DNA double-strand breaks in Chinese hamster V79 cells by 2-chlorodeoxyadenosine. Chemico-biological interactions, 1989, Volume: 71, Issue:2-3 Topics: 2-Chloroadenosine; Animals; Bucladesine; Cell Line; Cladribine; Cricetinae; Cricetulus; Cycloheximide; Deoxyadenosines; DNA; DNA Damage; Kinetics; Lung; Radioisotope Dilution Technique; Thymidine; Tritium	1989
dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. Nucleic acids symposium series, 1989, Issue:21 Topics: 2-Chloroadenosine; Animals; Cell Survival; Cladribine; Deoxyadenosines; Deoxyribonucleotides; DNA Damage; DNA, Neoplasm; Floxuridine; Mice; Tumor Cells, Cultured	1989
Profound toxicity of deoxyadenosine and 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: 2-Chloroadenosine; Cladribine; Deoxyadenosines; DNA Damage; Humans; In Vitro Techniques; Lymphoma; Monocytes; Pentostatin; T-Lymphocytes	1989
The mechanism of 2-chlorodeoxyadenosine-induced cell death. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: 2-Chloroadenosine; Cell Survival; Cladribine; Cycloheximide; Deoxyadenosines; Deoxycytidine; DNA Damage; Humans; Leukemia; Lymphoma; Tumor Cells, Cultured	1989
The 2-chlorodeoxyadenosine-induced cell death signalling pathway in human thymocytes is different from that induced by 2-chloroadenosine. The Biochemical journal, 1995, Oct-15, Volume: 311 ( Pt 2) Topics: 2-Chloroadenosine; Apoptosis; Blotting, Western; Calcium; Cell Death; Cladribine; Dipyridamole; DNA Damage; Endonucleases; Humans; Infant; Protein Kinase C; Signal Transduction; Thymus Gland; Tumor Suppressor Protein p53	1995
Apoptosis induced by 2-chloro-adenosine and 2-chloro-2'-deoxy-adenosine in a human astrocytoma cell line: differential mechanisms and possible clinical relevance. Journal of neuroscience research, 2000, May-01, Volume: 60, Issue:3 Topics: 2-Chloroadenosine; Animals; Antineoplastic Agents; Apoptosis; Astrocytoma; Brain Neoplasms; Cell Adhesion; Cell Division; Cell Line; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cladribine; Coloring Agents; Culture Media; Flow Cytometry; Humans; Mice; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2000
Stability study of selected adenosine nucleosides using LC and LC/MS analyses. Journal of pharmaceutical and biomedical analysis, 2000, Volume: 22, Issue:5 Topics: 2-Chloroadenosine; Chromatography, Liquid; Cladribine; Drug Stability; Hydrolysis; Kinetics; Mass Spectrometry	2000
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Molecular pharmacology, 2003, Volume: 63, Issue:6 Topics: 2-Chloroadenosine; Antineoplastic Agents; Apoptosis; Astrocytoma; Caspase 2; Caspase 3; Caspase 8; Caspase 9; Caspases; Cladribine; Cytochrome c Group; Enzyme Activation; Humans; Mitochondria; Tumor Cells, Cultured	2003
[nhibitory effect of adenosine analogues on invasion of human ovarian cancer cell line HO-8910PM]. Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:12 Topics: 2-Chloroadenosine; Antineoplastic Agents; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cladribine; Deoxyadenosines; Female; Histone Deacetylases; Humans; Inhibitory Concentration 50; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Ovarian Neoplasms; Repressor Proteins; RNA, Messenger; Trans-Activators	2004
Differential involvement of reactive oxygen species and nucleoside transporters in cytotoxicity induced by two adenosine analogues in human prostate cancer cells. The Prostate, 2009, Apr-01, Volume: 69, Issue:5 Topics: 2-Chloroadenosine; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Cladribine; Disease Models, Animal; Glutathione; Humans; Male; Mice; NF-E2-Related Factor 2; Nucleoside Transport Proteins; Prostatic Neoplasms; Purinergic P1 Receptor Agonists; Reactive Oxygen Species	2009