Page last updated: 2024-08-20

2-chloroadenosine and caffeine

2-chloroadenosine has been researched along with caffeine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (42.86)	18.7374
1990's	15 (42.86)	18.2507
2000's	4 (11.43)	29.6817
2010's	1 (2.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Butts-Lamb, P; Daly, JW; Padgett, W; Shamim, MT; Waters, J	1
Daly, JW	1
Arslan, G; Fredholm, BB; Kull, B; Lorenzen, A; Nilsson, C; Owman, C; Schwabe, U	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Bertarelli, DC; Borrmann, T; Florin, NC; Hinz, S; Li, W; Müller, CE; Scheiff, AB	1
de Lera Ruiz, M; Lim, YH; Zheng, J	1
Arizono, K; Brady, FO; Garrett, SH; Xiong, X	1
Albertson, TE; Derlet, RW; Tseng, JC	1
Farb, DH; Friedman, L; Gibbs, TT; Roca, DJ; Rozenberg, I; Schiller, GD	1
Mitsumoto, Y; Mohri, T; Ohkubo, T	1
Dulloo, AG; Girardier, L; Seydoux, J	1
Beninger, RJ; Josselyn, SA	1
Contreras, E; Germany, A; Villar, M	1
Baldwin, HA; File, SE	1
Holloway, WR; Thor, DH	1
Cheung, WT; Lee, CM; Ng, TB	1
Clark, RL; Cusick, WA; Eschbach, K; Heyse, JF	1
Coffin, VL; Spealman, RD	1
Ferrario, P; Mantegazza, P; Zambotti, F; Zecca, L; Zonta, N	1
Mantegazza, P; Tammiso, R; Zambotti, F; Zecca, L; Zonta, N	1
Lal, H; Spencer, DG	1
Butts-Lamb, P; Daly, JW; Padgett, W	1
Kulkarni, SK; Mehta, AK	1
Barber, R; Butcher, RW; Goka, TJ	1
Dragunow, M; Goddard, GV	1
Breimer, DD; Danhof, M; Ijzerman, AP; Mathoôt, RA; Soudijn, W	1
Behzadi, J; Mirnajafi-Zadeh, J; Pourgholami, MH	1
Lobo, MG; Oliveira, DG; Ribeiro, JA; Sebastião, AM	1
Mirnajafi-Zadeh, J; Palizvan, MR; Pourgholami, MH; Rostampour, M	1
Cunha, RA; Gonçalves, ML; Ribeiro, JA	1
Fallahi, M; Mirnajafi-Zadeh, J; Palizvan, MR; Pourgholami, MH; Rostampour, M	1
Flood, AJ; Headrick, JP; Willems, L	1
Klitgaard, H; Margineanu, DG	1

Reviews

3 review(s) available for 2-chloroadenosine and caffeine

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Adenosine receptors: targets for future drugs. Journal of medicinal chemistry, 1982, Volume: 25, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Humans; Ligands; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship; Xanthines	1982
Adenosine A2A receptor as a drug discovery target. Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Crystallography, X-Ray; Drug Discovery; Humans; Ligands; Protein Conformation; Receptor, Adenosine A2A; Signal Transduction	2014

Other Studies

32 other study(ies) available for 2-chloroadenosine and caffeine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. Journal of medicinal chemistry, 1985, Volume: 28, Issue:4 Topics: Adenosine; Animals; Cerebral Cortex; In Vitro Techniques; Rats; Receptors, Cell Surface; Receptors, Purinergic; Solubility; Structure-Activity Relationship	1985
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical pharmacology, 1999, Jan-01, Volume: 57, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; CHO Cells; Cloning, Molecular; Cricetinae; Cyclic AMP; Humans; Kinetics; PC12 Cells; Phenethylamines; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Triazoles; Tritium	1999
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. Journal of medicinal chemistry, 2009, Jul-09, Volume: 52, Issue:13 Topics: Adenosine A2 Receptor Antagonists; Animals; Drug Design; Humans; Kinetics; Ligands; Mice; Protein Binding; Radioligand Assay; Rats; Receptor, Adenosine A2B; Xanthines	2009
Purinergic agonist induction of metallothionein. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1992, Volume: 201, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Caffeine; Cells, Cultured; Cladribine; Deoxyadenosines; Dose-Response Relationship, Drug; Immunoblotting; Liver; Male; Metallothionein; Rats; Rats, Inbred Strains; RNA, Messenger; Theophylline; Time Factors; Transcription, Genetic; Vasodilator Agents	1992
Potentiation of cocaine and d-amphetamine toxicity with caffeine. The American journal of emergency medicine, 1992, Volume: 10, Issue:3 Topics: 2-Chloroadenosine; Animals; Caffeine; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Synergism; Male; Pentoxifylline; Poisoning; Rats; Rats, Inbred Strains; Seizures	1992
gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Molecular pharmacology, 1990, Volume: 37, Issue:5 Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Allosteric Regulation; Animals; Barbital; Barbiturates; Brain; Caffeine; Cells, Cultured; Chick Embryo; Flumazenil; Flunitrazepam; Flurazepam; gamma-Aminobutyric Acid; Kinetics; Neurons; Pentobarbital; Receptors, GABA-A; Tetrodotoxin; Theophylline; Veratridine	1990
Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives. Neuroscience letters, 1991, Dec-09, Volume: 133, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Affinity Labels; Animals; Biological Transport; Caffeine; Cells, Cultured; Cytarabine; Dipyridamole; Embryo, Mammalian; Hippocampus; Kinetics; Neuroglia; Neurons; Pentoxifylline; Rats; Sodium; Theophylline; Thioinosine; Tritium; Xanthines	1991
Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue. International journal of obesity, 1991, Volume: 15, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Adipose Tissue, Brown; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature Regulation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Ephedrine; Male; Oxygen Consumption; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Theophylline; Xanthines	1991
Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine. Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Animals; Behavior, Animal; Caffeine; Corpus Striatum; Dopamine; Flupenthixol; Male; Microinjections; Rats; Rats, Inbred Strains; Rotation; Stereoisomerism; Stereotyped Behavior	1991
Effects of some adenosine analogs on morphine-induced analgesia and tolerance. General pharmacology, 1990, Volume: 21, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Analgesics; Animals; Caffeine; Drug Synergism; Drug Tolerance; Injections, Intraventricular; Mice; Morphine; Naloxone; Phenylisopropyladenosine	1990
Caffeine-induced anxiogenesis: the role of adenosine, benzodiazepine and noradrenergic receptors. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Alprazolam; Anxiety; Caffeine; Chlordiazepoxide; Clonidine; Flumazenil; Motor Activity; Muscle Relaxants, Central; Norepinephrine; Propranolol; Receptors, Adrenergic; Receptors, GABA-A; Receptors, Purinergic; Social Behavior	1989
Interactive effects of caffeine, 2-chloroadenosine and haloperidol on activity, social investigation and play fighting of juvenile rats. Pharmacology, biochemistry, and behavior, 1985, Volume: 22, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Aggression; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Male; Motor Activity; Rats; Receptors, Cell Surface; Receptors, Purinergic; Social Behavior	1985
Potentiation of the anti-lipolytic effect of 2-chloroadenosine after chronic caffeine treatment. Pharmacology, 1988, Volume: 36, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Adipose Tissue; Animals; Body Weight; Caffeine; Cell Membrane; Drug Synergism; In Vitro Techniques; Lipolysis; Male; Organ Size; Radioligand Assay; Rats; Rats, Inbred Strains; Xanthines	1988
Interactions between caffeine and adenosine agonists in producing embryo resorptions and malformations in mice. Toxicology and applied pharmacology, 1987, Volume: 91, Issue:3 Topics: 2-Chloroadenosine; Abnormalities, Drug-Induced; Adenosine; Animals; Body Weight; Caffeine; Drug Administration Schedule; Drug Synergism; Embryo Loss; Female; Fetal Death; Mice; Mice, Inbred Strains; Phenylisopropyladenosine; Pregnancy	1987
Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Behavior, Animal; Blood Pressure; Caffeine; Cardiovascular System; Clonidine; Cocaine; Dextroamphetamine; Heart Rate; Isomerism; Macaca fascicularis; Male; Phenylisopropyladenosine	1987
Effects of 2-chloroadenosine on hippocampal GABA content and turnover. Journal of neural transmission, 1986, Volume: 65, Issue:3-4 Topics: 2-Chloroadenosine; 4-Aminobutyrate Transaminase; Adenosine; Aminooxyacetic Acid; Animals; Caffeine; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraventricular; Kinetics; Male; Rats; Rats, Inbred Strains	1986
Purine involvement in morphine antinociception. British journal of pharmacology, 1984, Volume: 83, Issue:4 Topics: 2-Chloroadenosine; Adenosine; Analgesia; Animals; Body Temperature; Bucladesine; Caffeine; Male; Morphine; Phenylisopropyladenosine; Rats; Rats, Inbred Strains	1984
Discriminative stimulus properties of L-phenylisopropyl adenosine: blockade by caffeine and generalization to 2-chloroadenosine. Life sciences, 1983, May-16, Volume: 32, Issue:20 Topics: 2-Chloroadenosine; Adenosine; Animals; Caffeine; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Male; Phenylisopropyladenosine; Rats; Receptors, Cell Surface; Receptors, Purinergic	1983
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cellular and molecular neurobiology, 1983, Volume: 3, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Animals; Brain; Caffeine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theobromine; Theophylline; Xanthines	1983
Evidence for the presence of P1- and P2-purinoceptors in rat caecum. Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 264, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Caffeine; Cecum; Cyclic AMP; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Quinidine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1983
Hormone and methylxanthine action on breast epithelial cells. Life sciences, 1984, Jun-18, Volume: 34, Issue:25 Topics: 2-Chloroadenosine; Adenosine; Animals; Breast; Breast Neoplasms; Caffeine; Cell Line; Cyclic AMP; Epithelium; Female; Fibrocystic Breast Disease; Humans; Mice; Terbutaline; Xanthines	1984
Adenosine modulation of amygdala kindling. Experimental neurology, 1984, Volume: 84, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Aminophylline; Amygdala; Animals; Caffeine; Differential Threshold; Kindling, Neurologic; Male; Papaverine; Rats; Rats, Inbred Strains; Seizures	1984
Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. British journal of pharmacology, 1996, Volume: 118, Issue:2 Topics: 2-Chloroadenosine; Animals; Caffeine; Hemodynamics; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline	1996
Effect of intraperitoneal and intrahippocampal (CA1) 2-chloroadenosine in amygdaloid kindled rats. Brain research, 1997, Mar-21, Volume: 751, Issue:2 Topics: 2-Chloroadenosine; Amygdala; Animals; Caffeine; Central Nervous System Stimulants; Electrophysiology; Hippocampus; Injections; Injections, Intraperitoneal; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Seizures	1997
On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor present in rat motor nerve terminals. Pharmacology & toxicology, 1997, Volume: 80, Issue:6 Topics: 2-Chloroadenosine; Animals; Caffeine; Electric Stimulation; Female; In Vitro Techniques; Male; Neuromuscular Junction; Presynaptic Terminals; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Xanthines	1997
Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain research, 1997, Nov-14, Volume: 775, Issue:1-2 Topics: 2-Chloroadenosine; Amygdala; Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Injections; Kindling, Neurologic; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Seizures; Time Factors	1997
Adenosine A2A receptors facilitate 45Ca2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neuroscience letters, 1997, Nov-28, Volume: 238, Issue:1-2 Topics: 2-Chloroadenosine; Adenosine; Animals; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Hippocampus; Male; omega-Agatoxin IVA; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Spider Venoms; Synaptosomes; Veratridine; Xanthines	1997
Anticonvulsant action of 2-chloroadenosine injected focally into the perirhinal cortex in amygdaloid kindled rats. Epilepsy research, 1999, Volume: 37, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Amygdala; Analysis of Variance; Animals; Anticonvulsants; Caffeine; Dose-Response Relationship, Drug; Injections; Kindling, Neurologic; Male; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures	1999
Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart. Cardiovascular research, 2002, Volume: 55, Issue:1 Topics: 2-Chloroadenosine; Adenosine; Adenosine Diphosphate; Animals; Caffeine; Coronary Circulation; Heart; Male; Mice; Mice, Inbred C57BL; Models, Animal; Myocardial Contraction; Myocardial Reperfusion Injury; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Antagonists; Vasodilator Agents; Xanthines	2002
Caffeine-induced epileptiform field potentials in rat hippocampal slices: a pharmacological characterization. Neuropharmacology, 2004, Volume: 47, Issue:6 Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Caffeine; Calcium; Calcium Channel Blockers; Calcium Signaling; Central Nervous System Stimulants; Electrophysiology; Enzyme Inhibitors; Epilepsy; Evoked Potentials; Flunarizine; Hippocampus; In Vitro Techniques; Male; Perfusion; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Ruthenium Red; Ryanodine Receptor Calcium Release Channel; Thapsigargin	2004