Page last updated: 2024-08-20

2-chloroadenosine and 8-chloroadenosine

2-chloroadenosine has been researched along with 8-chloroadenosine in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	12 (21.05)	18.2507
2000's	29 (50.88)	29.6817
2010's	12 (21.05)	24.3611
2020's	4 (7.02)	2.80

Authors

Authors	Studies
Taylor, CW; Yeoman, LC	1
Heimans, JJ; Jongenelen, CA; Langeveld, CH; Stoof, JC	1
Fang, J; Shi, Y; Zhang, L	1
Borsellino, N; Crescimanno, M; D'Alessandro, N; Leonardi, V	1
Cummings, J; Leonard, RC; Miller, WR	1
Lange-Carter, CA; Malkinson, AM; Vuillequez, JJ	1
Chatterjee, D; Han, Z; Wyche, JH	1
Baak, JP; Heimans, JJ; Jongenelen, CA; Langeveld, CH; Peters, GJ; Stoof, JC; Theeuwes, JW	1
Bell, PB; Bosanquet, AG; Burlton, AR; Harris, AL	1
Halgren, RG; Heller, KF; Krett, NL; Pillay, S; Rosen, ST; Traynor, AE; Zell, JL	1
Liu, S; Zhang, S; Zheng, D	1
Lou, Y; Wang, X; Zhang, W; Zou, A	1
Allen, PD; Jia, L; Kelsey, SM; Newland, AC; Yin, Y	1
Ayres, M; Gandhi, V; Halgren, RG; Krett, NL; Newman, RA; Rosen, ST	1
Harris, AL; Houlbrook, S; Priddle, JD; Robbins, SK	1
Yang, P; Zhang, H	1
Lamb, D; Steinberg, RA	1
Ayres, M; Chen, W; Gandhi, V; Madden, TL; Newman, RA; Rhie, JK	1
Choe, J; Choo, HJ; Kim, MK; Park, GH; Park, YG; Sohn, J	1
Chen, LS; Sheppard, TL	1
Chang, XY; Fang, JC; Liu, T; Su, H; Wang, NQ	1
Ayres, M; Gandhi, V; Rodriguez, CO; Stellrecht, CM	1
Yang, P; Zhang, HR	1
Cui, JR; Wu, J; Xu, B; Zhang, LH; Zhang, Y	1
Liu, S; Liu, Y; Wang, M; Zheng, D	1
Bollag, WB; Josephson, S; Zhong, X	1
Ahn, YH; Hong, SH; Jung, JM	2
Chen, WQ; Qi, XR; Shi, J; Yang, L; Zhang, Q	1
Cui, JR; Strada, SJ; Zhang, LH; Zhao, YM; Zhu, B	1
Janković, D; Kanazir, S; Marković, I; Marković, J; Pesić, M; Rakić, L; Ruzdijić, S	1
Liu, SL; Liu, YX; Wang, MJ; Zhang, JC; Zheng, DX	1
Gu, YY; Jia, HT; Li, SY; Ni, JH; Zhang, HJ; Zhang, HY	1
Cervantes-Gomez, F; Gandhi, V; Phillip, CJ; Stellrecht, CM	1
Bauer, A; Greene, E; Hsiao, HP; Krett, NL; Leitner, WW; Nesterova, M; Robinson-White, AJ; Stratakis, CA	1
An, GS; Feng, LY; Jia, HT; Jia, XZ; Li, SY; Ni, JH; Yang, SY	1
An, GS; Jia, HT; Jia, XZ; Li, SY; Ni, JH; Yang, SY; Zhou, J	1
Jia, HT; Li, SY; Li, WJ; Ni, JH; Yang, SY; Zhang, HJ	1
Ayres, ML; Chen, LS; Gandhi, V; Krett, NL; Nowak, BJ; Rosen, ST; Zhang, S	1
Gu, YY; Jia, HT; Li, WJ; Zhang, HJ; Zhou, J	1
Arya, R; Ayres, M; Gandhi, V; Stellrecht, CM	1
Balakrishnan, K; Dennison, JB; Gandhi, V	1
Ayres, ML; Dennison, JB; Gandhi, V; Kaluarachchi, K; Plunkett, W	1
Gao, WL; Li, N; Liu, H; Zong, MH	1
An, GS; Cai, WW; Cao, JX; Duan, HY; Jia, HT; Li, SY; Ni, JH; Qi, JJ; Wu, GS	1
Feng, G; Gandhi, V; Krett, NL; McBrayer, SK; Qian, J; Rosen, ST; Shanmugam, M; Yarrington, M	1
Jiao, YY; Lu, WL; Wang, XQ; Yang, ZJ; Zhang, Q	1
An, GS; Cao, JX; Han, YY; Jia, HT; Jin, YQ; Li, SY; Ni, JH; Zhang, YX; Zhou, Z	1
Le, XF; Mao, W; Shentu, S; Stellrecht, CM; Vangapandu, HV	1
Borghi, MO; Caraglia, M; Dicitore, A; Gaudenzi, G; Grassi, ES; Hofland, LJ; Persani, L; Vitale, G	1
Fan, YH; Gandhi, V; Giri, U; Heymach, JV; Kearney, AY; Saigal, B; Zurita, AJ	1
An, GS; Jia, HT; Li, SY; Li, Y; Ni, JH; Yang, SY	1
Fu, S; Hawkins, CL; Rayner, BS; Tang, V	1
Hawkins, CL; Macer-Wright, JL; Rayner, BS; Sileikaite, I	1
Buettner, R; Chen, LS; Chen, MH; Gandhi, V; Hernandez Vargas, S; Hoang, DH; Marcucci, G; Morales, C; Nguyen, LXT; Pullarkat, V; Rosen, ST; Wu, X	1
Akhter, I; Ayres, ML; Diao, L; Ding, J; Fan, Y; Galan-Cobo, A; Gandhi, V; Giri, U; Gudikote, J; Heymach, JV; Minna, JD; Nilsson, M; Qian, Y; Qu, X; Skoulidis, F; Stellrecht, CM; Tong, P; Wang, J; Wierda, WG; Yang, C; Yilmaz, E	1
Cottrell, KA; Dizon, MG; Torres, LS; Weber, JD	1

Other Studies

57 other study(ies) available for 2-chloroadenosine and 8-chloroadenosine

Article	Year
Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anti-cancer drugs, 1992, Volume: 3, Issue:5 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Biotransformation; Blood; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Prodrugs; Tumor Cells, Cultured	1992
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate. Cancer research, 1992, Jul-15, Volume: 52, Issue:14 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Adenylyl Cyclases; Cell Division; Chromatography, High Pressure Liquid; Glioma; Humans; Receptors, Purinergic; Tumor Cells, Cultured	1992
[Antitumor activities of 8-chloroadenosine in vivo and in vitro]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 1995, Volume: 17, Issue:1 Topics: 2-Chloroadenosine; Animals; Antineoplastic Agents; Female; Lethal Dose 50; Leukemia L1210; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Rats; Rats, Wistar; Stomach Neoplasms; Tumor Cells, Cultured	1995
Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines. Pharmacological research, 1994, Volume: 30, Issue:1 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Doxorubicin; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Tumor Cells, Cultured	1994
Sensitive determination of 8-chloroadenosine 3',5'-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1994, Aug-05, Volume: 658, Issue:1 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Quality Control; Sensitivity and Specificity	1994
8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer research, 1993, Jan-15, Volume: 53, Issue:2 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Cell Division; Cell Survival; Cyclic AMP; Epithelium; Gene Expression; Lung; Lung Neoplasms; Mice; Protein Kinases; RNA, Messenger	1993
Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: 2-Chloroadenosine; 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Biotransformation; Blood; Cattle; Cell Division; Cells, Cultured; Humans; Mice; Rats	1993
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics. Biochemical pharmacology, 1997, Jan-24, Volume: 53, Issue:2 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Cycle; Cell Division; DNA; Flow Cytometry; Humans; RNA; Tumor Cells, Cultured	1997
Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP. British journal of cancer, 1997, Volume: 76, Issue:4 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Drug Evaluation; Drug Resistance; Humans; Neoplasms	1997
8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine. Blood, 1998, Oct-15, Volume: 92, Issue:8 Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Biotransformation; Cattle; Culture Media; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Interleukin-6; Multiple Myeloma; Phosphoric Diester Hydrolases; Prodrugs; Thioinosine; Tumor Cells, Cultured	1998
[8-chloro-adenosine induced apoptosis in various human tumor cell lines]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 1998, Volume: 20, Issue:2 Topics: 2-Chloroadenosine; 3T3 Cells; Adenocarcinoma, Mucinous; Animals; Antineoplastic Agents; Apoptosis; DNA Fragmentation; HL-60 Cells; Humans; Mice; Stomach Neoplasms; Tumor Cells, Cultured	1998
Determination of pharmacokinetics of 8-chloroadenosine and its two major metabolites in dogs by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2000, Sep-15, Volume: 746, Issue:2 Topics: 2-Chloroadenosine; Animals; Chromatography, High Pressure Liquid; Dogs; Reproducibility of Results; Tissue Distribution	2000
8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB. Leukemia research, 2001, Volume: 25, Issue:5 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Growth Inhibitors; Humans; I-kappa B Proteins; Leukemia, T-Cell; NF-kappa B; NF-KappaB Inhibitor alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vinblastine	2001
8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer research, 2001, Jul-15, Volume: 61, Issue:14 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Adenosine Triphosphate; Antineoplastic Agents; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Time Factors; Tumor Cells, Cultured	2001
8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs. Cancer chemotherapy and pharmacology, 2001, Volume: 48, Issue:6 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chlorine Compounds; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Temperature	2001
[8-chloroadenosine inhibits the growth factor-induced proliferation of retinal pigment epithelial cells in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1998, Volume: 34, Issue:4 Topics: 2-Chloroadenosine; Animals; Cattle; Cell Division; DNA; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Interleukin-1; Pigment Epithelium of Eye; Tumor Necrosis Factor-alpha	1998
Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression. Journal of cellular physiology, 2002, Volume: 192, Issue:2 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Animals; Antineoplastic Agents; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Humans; Mice; Mutation; Protein Subunits; Tumor Cells, Cultured	2002
Plasma and cellular pharmacology of 8-chloro-adenosine in mice and rats. Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:2 Topics: 2-Chloroadenosine; Adenosine Deaminase; Adenosine Kinase; Adenosine Triphosphate; Animals; Antimetabolites, Antineoplastic; Biotransformation; Chromatography, High Pressure Liquid; Female; Inosine; Leukocytes, Mononuclear; Male; Mice; Pentostatin; Phosphorylation; Prodrugs; Rats; Rats, Sprague-Dawley; Species Specificity	2002
Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray. Experimental & molecular medicine, 2002, Jul-31, Volume: 34, Issue:3 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Blotting, Western; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation	2002
Synthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:8-9 Topics: 2-Chloroadenosine; Circular Dichroism; Hot Temperature; Molecular Structure; Nucleic Acid Denaturation; Nucleic Acid Hybridization; RNA; RNA Stability; RNA, Complementary; Ultraviolet Rays	2002
[8-Chloro-adenosine increases the activity of transcription factor CREB by modification of phosphorylation]. Ai zheng = Aizheng = Chinese journal of cancer, 2003, Volume: 22, Issue:4 Topics: 2-Chloroadenosine; Cyclic AMP Response Element-Binding Protein; HL-60 Cells; Humans; Phosphorylation; Transcription Factors	2003
RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer research, 2003, Nov-15, Volume: 63, Issue:22 Topics: 2-Chloroadenosine; Adenosine Triphosphate; Humans; Multiple Myeloma; RNA, Messenger; RNA, Neoplasm; RNA, Ribosomal; Substrate Specificity; Transcription, Genetic	2003
[The inhibitory effect of 8-chloroadenosine on tumor necrosis factor-induced proto-oncogene expression of retinal pigment epithelial cells]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2003, Volume: 39, Issue:12 Topics: 2-Chloroadenosine; Animals; Cattle; Genes, fos; Genes, myc; Immunohistochemistry; Pigment Epithelium of Eye; RNA; RNA, Messenger; Tumor Necrosis Factor-alpha	2003
[Inhibition of 8-chloroadenosine on proteasome activity of HL-60 cells]. Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:2 Topics: 2-Chloroadenosine; Apoptosis; Cysteine Endopeptidases; HL-60 Cells; Humans; Multienzyme Complexes; NF-kappa B; Precipitin Tests; Proteasome Endopeptidase Complex	2004
8-Chloro-adenosine sensitizes a human hepatoma cell line to TRAIL-induced apoptosis by caspase-dependent and -independent pathways. Oncology reports, 2004, Volume: 12, Issue:1 Topics: 2-Chloroadenosine; Apoptosis; Apoptosis Regulatory Proteins; Base Sequence; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; DNA Primers; Humans; Membrane Glycoproteins; NF-kappa B; Recombinant Proteins; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha	2004
8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes. BMC pharmacology, 2004, Jul-27, Volume: 4 Topics: 2-Chloroadenosine; Animals; Calcitriol; Cell Differentiation; Cell Proliferation; Cells, Cultured; Dermatologic Agents; DNA; Drug Interactions; Keratin-1; Keratinocytes; Keratins; Mice; Mice, Inbred ICR; Transglutaminases	2004
8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation. Journal of cellular physiology, 2004, Volume: 201, Issue:2 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Division; Cyclin B; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Mice; NIH 3T3 Cells; Protein Kinase C; Signal Transduction	2004
8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer research, 2005, Jun-01, Volume: 65, Issue:11 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HL-60 Cells; Humans; K562 Cells; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases	2005
[Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats]. Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:4 Topics: 2-Chloroadenosine; Animals; Antineoplastic Agents; Area Under Curve; Delayed-Action Preparations; Liposomes; Male; Nanostructures; Particle Size; Rats; Rats, Wistar	2005
8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1/CIP1). Journal of cellular biochemistry, 2006, Jan-01, Volume: 97, Issue:1 Topics: 2-Chloroadenosine; Apoptosis; Blotting, Western; Cell Differentiation; Cell Division; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; G1 Phase; HL-60 Cells; Humans; Resting Phase, Cell Cycle; Telomerase	2006
The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro. Investigational new drugs, 2006, Volume: 24, Issue:1 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Neuroblastoma; Purine Nucleosides; Time Factors	2006
[Mechanisms of sensitization by 8-chloro-adenosine of human tumor cells to TRAIL-induced apoptosis]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 2005, Volume: 27, Issue:10 Topics: 2-Chloroadenosine; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha	2005
8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells. Biochemical pharmacology, 2006, Aug-28, Volume: 72, Issue:5 Topics: 2-Chloroadenosine; Actins; Biopolymers; Blotting, Western; Cell Division; Cell Separation; Flow Cytometry; Humans; Immunohistochemistry; Lung Neoplasms; Tumor Cells, Cultured	2006
Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase. Cancer research, 2007, Oct-15, Volume: 67, Issue:20 Topics: 2-Chloroadenosine; Cell Death; Cell Growth Processes; Cell Lineage; DNA, Complementary; Gene Expression; Humans; Multiple Myeloma; Proto-Oncogene Proteins c-met; RNA, Catalytic; RNA, Messenger; RNA, Small Interfering	2007
Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine. The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Humans; Signal Transduction; Thyroid Neoplasms	2008
Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochemical pharmacology, 2009, Feb-01, Volume: 77, Issue:3 Topics: 2-Chloroadenosine; Adenosine Triphosphate; Biocatalysis; DNA Damage; Humans; Hydrolysis; K562 Cells; Leukemia, Myeloid; Topoisomerase II Inhibitors	2009
Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells. Biochemical pharmacology, 2009, Mar-01, Volume: 77, Issue:5 Topics: 2-Chloroadenosine; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; BRCA1 Protein; Carbazoles; Cell Cycle Proteins; Cell Division; Checkpoint Kinase 1; DNA-Binding Proteins; Flow Cytometry; G2 Phase; Humans; Immunohistochemistry; Immunoprecipitation; K562 Cells; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Replication Origin; S Phase; Tumor Suppressor Proteins	2009
8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites. Journal of cellular biochemistry, 2009, Feb-15, Volume: 106, Issue:3 Topics: 2-Chloroadenosine; Cell Line, Tumor; E2F1 Transcription Factor; Humans; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Sp1 Transcription Factor; Transcriptional Activation; Tumor Suppressor Protein p14ARF; Up-Regulation	2009
Inhibition of ATP synthase by chlorinated adenosine analogue. Biochemical pharmacology, 2009, Sep-15, Volume: 78, Issue:6 Topics: 2-Chloroadenosine; Adenosine; Antineoplastic Agents; ATP Synthetase Complexes; Glycolysis; Halogenation; Hydrolysis; Models, Molecular; Oxygen Consumption; Protein Binding; Protein Conformation	2009
Induction of p14ARF by E2F1 contributes to 8-chloro-adenosine-induced apoptosis in human lung cancer H1299 cells. Chemotherapy, 2009, Volume: 55, Issue:5 Topics: 2-Chloroadenosine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; E2F1 Transcription Factor; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mitosis; RNA Interference; Tumor Suppressor Protein p14ARF	2009
A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels. Breast cancer research and treatment, 2010, Volume: 121, Issue:2 Topics: 2-Chloroadenosine; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cell Survival; Chromatography, High Pressure Liquid; Cyclin E; Female; Flow Cytometry; Humans; Reverse Transcriptase Polymerase Chain Reaction; RNA	2010
Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. British journal of haematology, 2009, Volume: 147, Issue:3 Topics: 2-Chloroadenosine; Adenosine Triphosphate; Antineoplastic Agents; Cell Cycle; Cell Death; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Lymphoma, Mantle-Cell; Transcription, Genetic; Tumor Cells, Cultured	2009
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels. The Journal of biological chemistry, 2010, Mar-12, Volume: 285, Issue:11 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Line, Tumor; Citric Acid Cycle; Dose-Response Relationship, Drug; Energy Metabolism; Fumarates; Humans; Hypoglycemic Agents; Lymphoma, Mantle-Cell; Metformin; Oligomycins; Purines; Succinic Acid; Uncoupling Agents	2010
Regioselective enzymatic undecylenoylation of 8-chloroadenosine and its analogs with biomass-based 2-methyltetrahydrofuran as solvent. Bioresource technology, 2012, Volume: 118 Topics: 2-Chloroadenosine; Biomass; Enzyme Stability; Enzymes, Immobilized; Furans; Lipase; Nucleosides; Penicillium; Solvents; Stereoisomerism; Substrate Specificity; Temperature	2012
E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells. Biochemistry. Biokhimiia, 2012, Volume: 77, Issue:3 Topics: 2-Chloroadenosine; Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Damage; E2F1 Transcription Factor; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; M Phase Cell Cycle Checkpoints	2012
Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms. PloS one, 2012, Volume: 7, Issue:7 Topics: 2-Chloroadenosine; Adenosine; Cell Line, Tumor; Clinical Trials, Phase I as Topic; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucosephosphate Dehydrogenase; Hematologic Neoplasms; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasm Proteins; Pentose Phosphate Pathway; RNA, Neoplasm	2012
A novel approach to improve the pharmacokinetic properties of 8-chloro-adenosine by the dual combination of lipophilic derivatisation and liposome formulation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013, Jan-23, Volume: 48, Issue:1-2 Topics: 2-Chloroadenosine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Fatty Acids; Humans; Liposomes; Male; Polyethylene Glycols; Rats; Rats, Sprague-Dawley	2013
E2F1-mediated DNA damage is implicated in 8-Cl-adenosine-induced chromosome missegregation and apoptosis in human lung cancer H1299 cells. Molecular and cellular biochemistry, 2013, Volume: 384, Issue:1-2 Topics: 2-Chloroadenosine; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromosome Aberrations; Chromosome Segregation; Chromosomes; DNA Breaks, Double-Stranded; Down-Regulation; E2F1 Transcription Factor; Histones; Humans; Lung Neoplasms; Mitosis; RNA Interference; RNA, Small Interfering; Tetraploidy; Tumor Suppressor Protein p14ARF	2013
ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. Journal of hematology & oncology, 2014, Mar-14, Volume: 7 Topics: 2-Chloroadenosine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Humans; MCF-7 Cells; Mice; Phosphorylation; Random Allocation; Signal Transduction; Xenograft Model Antitumor Assays	2014
The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines. Endocrine, 2016, Volume: 51, Issue:1 Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Amines; Antineoplastic Agents; Apoptosis; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; MAP Kinase Signaling System; Piperidines; Proto-Oncogene Mas; Thyroid Neoplasms	2016
8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PloS one, 2015, Volume: 10, Issue:8 Topics: 2-Chloroadenosine; AMP-Activated Protein Kinases; Blotting, Western; Carcinoma, Renal Cell; Cell Cycle; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Kidney Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Array Analysis; Protein Kinase Inhibitors; Proteomics; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured	2015
DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299 Cells Determines Sensitivity to 8-Chloro-Adenosine. International journal of molecular sciences, 2018, May-28, Volume: 19, Issue:6 Topics: 2-Chloroadenosine; A549 Cells; Antineoplastic Agents; Cell Cycle Proteins; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Cyclin-Dependent Kinase Inhibitor p21; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; DNA Topoisomerases, Type I; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Organ Specificity; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Signal Transduction; Tumor Suppressor Protein p53	2018
8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response. Redox biology, 2019, Volume: 26 Topics: 2-Chloroadenosine; Antioxidants; Apoptosis; Cell Line; Coronary Vessels; DNA; Endothelial Cells; Glycolysis; Human Umbilical Vein Endothelial Cells; Humans; Mitochondria; Oxidation-Reduction; RNA; Unfolded Protein Response	2019
8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages. Chemical research in toxicology, 2020, 02-17, Volume: 33, Issue:2 Topics: 2-Chloroadenosine; Animals; Antioxidants; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Damage; DNA Repair; Macrophages; Mice	2020
Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine. Journal of hematology & oncology, 2021, 04-26, Volume: 14, Issue:1 Topics: 2-Chloroadenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Oxidative Phosphorylation; Sulfonamides	2021
Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado. Molecular cancer research : MCR, 2022, Volume: 20, Issue:2 Topics: 2-Chloroadenosine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Homeostasis; Humans; Lung Neoplasms; Mutation; Oxidation-Reduction; Signal Transduction; Transfection	2022
8-azaadenosine and 8-chloroadenosine are not selective inhibitors of ADAR. Cancer research communications, 2021, Volume: 1, Issue:2 Topics: 2-Chloroadenosine; Adenosine; Interferon Type I	2021