2-chloroadenosine has been researched along with 8-bromo cyclic adenosine monophosphate in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.59) | 18.7374 |
| 1990's | 14 (41.18) | 18.2507 |
| 2000's | 10 (29.41) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taylor, CW; Yeoman, LC | 1 |
| Heimans, JJ; Jongenelen, CA; Langeveld, CH; Stoof, JC | 1 |
| Ishimura, Y; Kizaki, H; Suzuki, K; Tadakuma, T | 1 |
| Baldessarini, RJ; Booth, RG | 1 |
| Chambaut-Guerin, AM; Delbourg, I; Ribier, A; Thomopoulos, P; Ventura, MA | 1 |
| Dejana, E; Gaboli, M; Giorgi, M; Lampugnani, MG; Marchisio, PC | 1 |
| Alexander, SP; Hill, SJ; Kendall, DA | 1 |
| Gross, RA; Macdonald, RL; Ryan-Jastrow, T | 1 |
| Cullen, JJ; Welsh, MJ | 1 |
| Block, T; Breckenridge, BM; Kon, C | 1 |
| Archer, ER; Dolphin, AC | 1 |
| Fredholm, BB; Lerner, U | 1 |
| Perrin, MH; Smith, MA; Vale, WW | 1 |
| Borsellino, N; Crescimanno, M; D'Alessandro, N; Leonardi, V | 1 |
| Cummings, J; Leonard, RC; Miller, WR | 1 |
| Lange-Carter, CA; Malkinson, AM; Vuillequez, JJ | 1 |
| Chatterjee, D; Han, Z; Wyche, JH | 1 |
| Baak, JP; Heimans, JJ; Jongenelen, CA; Langeveld, CH; Peters, GJ; Stoof, JC; Theeuwes, JW | 1 |
| Kataoka, K; Nakamura, Y; Si, QS | 1 |
| Bell, PB; Bosanquet, AG; Burlton, AR; Harris, AL | 1 |
| Halgren, RG; Heller, KF; Krett, NL; Pillay, S; Rosen, ST; Traynor, AE; Zell, JL | 1 |
| Allen, PD; Jia, L; Kelsey, SM; Newland, AC; Yin, Y | 1 |
| Ayres, M; Gandhi, V; Halgren, RG; Krett, NL; Newman, RA; Rosen, ST | 1 |
| Harris, AL; Houlbrook, S; Priddle, JD; Robbins, SK | 1 |
| Lamb, D; Steinberg, RA | 1 |
| Choe, J; Choo, HJ; Kim, MK; Park, GH; Park, YG; Sohn, J | 1 |
| Holoshitz, J; Linden, J; Wu, Y; Zheng, J | 1 |
| Ahn, YH; Hong, SH; Jung, JM | 2 |
| Janković, D; Kanazir, S; Marković, I; Marković, J; Pesić, M; Rakić, L; Ruzdijić, S | 1 |
| Bauer, A; Greene, E; Hsiao, HP; Krett, NL; Leitner, WW; Nesterova, M; Robinson-White, AJ; Stratakis, CA | 1 |
| Ayres, ML; Dennison, JB; Gandhi, V; Kaluarachchi, K; Plunkett, W | 1 |
| Cristalli, G; Di Angelantonio, S; Grassi, F; Limatola, C; Moriconi, C; Piccioni, A; Trettel, F | 1 |
| Borghi, MO; Caraglia, M; Dicitore, A; Gaudenzi, G; Grassi, ES; Hofland, LJ; Persani, L; Vitale, G | 1 |
34 other study(ies) available for 2-chloroadenosine and 8-bromo cyclic adenosine monophosphate
| Article | Year |
|---|---|
Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Biotransformation; Blood; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Culture Media; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Prodrugs; Tumor Cells, Cultured | 1992 |
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Adenylyl Cyclases; Cell Division; Chromatography, High Pressure Liquid; Glioma; Humans; Receptors, Purinergic; Tumor Cells, Cultured | 1992 |
Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bucladesine; Cell Survival; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Kinetics; Male; Mice; Mice, Inbred BALB C; Phenylisopropyladenosine; Receptors, Purinergic; T-Lymphocytes | 1990 |
Adenosine A2 stimulation of tyrosine hydroxylase in rat striatal minces is reversed by dopamine D2 autoreceptor activation.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Apomorphine; Colforsin; Corpus Striatum; Cyclic AMP; Dopamine Agents; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Purinergic; Theophylline; Tyrosine 3-Monooxygenase | 1990 |
The adhesiveness of monocytic U937 cells is stimulated by pro-inflammatory agents and inhibited by adenosine 3':5'-cyclic monophosphate.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Alprostadil; Bucladesine; Calcitriol; Cell Adhesion; Cell Differentiation; Cell Line; Cyclic AMP; Diglycerides; Humans; Kinetics; Leukotriene B4; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Platelet Activating Factor; Tretinoin | 1990 |
Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Actin Cytoskeleton; Cell Adhesion; Cell Movement; Colforsin; Cyclic AMP; Endothelium, Vascular; Humans; Integrins; Monensin | 1990 |
Differences in the adenosine receptors modulating inositol phosphates and cyclic AMP accumulation in mammalian cerebral cortex.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cerebral Cortex; Colforsin; Cyclic AMP; Female; Guinea Pigs; In Vitro Techniques; Inositol Phosphates; Kinetics; Lithium; Male; Mice; Receptors, Purinergic; Second Messenger Systems; Xanthines | 1989 |
2-Chloroadenosine reduces the N calcium current of cultured mouse sensory neurones in a pertussis toxin-sensitive manner.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Adenylate Cyclase Toxin; Animals; Calcium; Cells, Cultured; Depression, Chemical; Ganglia, Spinal; Mice; Muscle Relaxants, Central; Neurons, Afferent; Pertussis Toxin; Virulence Factors, Bordetella | 1989 |
Regulation of sodium absorption by canine tracheal epithelium.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Aldosterone; Amiloride; Animals; Calcimycin; Cattle; Electric Conductivity; Epithelium; In Vitro Techniques; Indomethacin; Isoproterenol; Prostaglandins E; Sodium; Trachea; Water-Electrolyte Balance | 1987 |
Mutants of PC12 cells with altered cyclic AMP responses.
Topics: 2-Chloroadenosine; 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Animals; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Mutation; Phenotype; Pheochromocytoma; Rats | 1984 |
An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Potassium; Rats; Theophylline | 1983 |
2-chloroadenosine increases calcium mobilization from mouse calvaria in vitro.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adenosine; Animals; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Cyclic AMP; Mice; Purines | 1982 |
Interaction of adenosine 3',5'-monophosphate derivatives with the gonadotropin-releasing hormone receptor on pituitary and ovary.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine Monophosphate; Animals; Bucladesine; Cattle; Cyclic AMP; Female; Male; Ovary; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, LHRH; Thionucleotides | 1982 |
Effects of 8-chloro-cyclic adenosine monophosphate on the growth and sensitivity to doxorubicin of multidrug-resistant tumour cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Antineoplastic Agents; Cell Division; Doxorubicin; Drug Resistance, Multiple; Melanoma, Experimental; Mice; Tumor Cells, Cultured | 1994 |
Sensitive determination of 8-chloroadenosine 3',5'-monophosphate and 8-chloroadenosine in plasma by high-performance liquid chromatography.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Humans; Quality Control; Sensitivity and Specificity | 1994 |
8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Cell Division; Cell Survival; Cyclic AMP; Epithelium; Gene Expression; Lung; Lung Neoplasms; Mice; Protein Kinases; RNA, Messenger | 1993 |
Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP.
Topics: 2-Chloroadenosine; 3',5'-Cyclic-AMP Phosphodiesterases; 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Biotransformation; Blood; Cattle; Cell Division; Cells, Cultured; Humans; Mice; Rats | 1993 |
The antiproliferative effect of 8-chloro-adenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate, and disturbances in nucleic acid synthesis and cell cycle kinetics.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Cycle; Cell Division; DNA; Flow Cytometry; Humans; RNA; Tumor Cells, Cultured | 1997 |
Adenosine inhibits superoxide production in rat peritoneal macrophages via elevation of cAMP level.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Bucladesine; Cyclic AMP; Enzyme Activation; Intracellular Fluid; Macrophages, Peritoneal; Male; Protein Kinase C; Rats; Rats, Wistar; Superoxides; Xanthines | 1997 |
Ex vivo cytotoxic drug evaluation by DiSC assay to expedite identification of clinical targets: results with 8-chloro-cAMP.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Drug Evaluation; Drug Resistance; Humans; Neoplasms | 1997 |
8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Deaminase; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Biotransformation; Cattle; Culture Media; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Interleukin-6; Multiple Myeloma; Phosphoric Diester Hydrolases; Prodrugs; Thioinosine; Tumor Cells, Cultured | 1998 |
8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biotransformation; Cell Division; Cell Nucleus; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Growth Inhibitors; Humans; I-kappa B Proteins; Leukemia, T-Cell; NF-kappa B; NF-KappaB Inhibitor alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vinblastine | 2001 |
8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Adenosine Triphosphate; Antineoplastic Agents; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Humans; Multiple Myeloma; Time Factors; Tumor Cells, Cultured | 2001 |
8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Antineoplastic Agents; Cell Division; Chlorine Compounds; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Temperature | 2001 |
Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Kinase; Animals; Antineoplastic Agents; Cell Division; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Humans; Mice; Mutation; Protein Subunits; Tumor Cells, Cultured | 2002 |
Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Blotting, Western; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Neuroblastoma; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Tumor Cells, Cultured; Up-Regulation | 2002 |
Genoprotective pathways. Part I. Extracellular signaling through G(s) protein-coupled adenosine receptors prevents oxidative DNA damage.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antimutagenic Agents; Base Sequence; Cell Line; Comet Assay; DNA Damage; DNA Primers; GTP-Binding Protein alpha Subunits, Gs; Humans; Oxidative Stress; Receptors, Purinergic P1; Signal Transduction | 2004 |
8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Cell Division; Cyclin B; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Mice; NIH 3T3 Cells; Protein Kinase C; Signal Transduction | 2004 |
8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Growth Processes; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; HL-60 Cells; Humans; K562 Cells; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases | 2005 |
The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Neuroblastoma; Purine Nucleosides; Time Factors | 2006 |
Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Humans; Signal Transduction; Thyroid Neoplasms | 2008 |
Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Antineoplastic Agents; Cell Line, Tumor; Citric Acid Cycle; Dose-Response Relationship, Drug; Energy Metabolism; Fumarates; Humans; Hypoglycemic Agents; Lymphoma, Mantle-Cell; Metformin; Oligomycins; Purines; Succinic Acid; Uncoupling Agents | 2010 |
Adenosine A2A receptor induces protein kinase A-dependent functional modulation of human (alpha)3(beta)4 nicotinic receptor.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electrophysiological Phenomena; HEK293 Cells; Humans; Mice; Mice, Inbred C57BL; Neurons; Nicotine; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Pyrroles; Receptor, Adenosine A2A; Receptors, Nicotinic; Signal Transduction; Superior Cervical Ganglion; Transfection; Triazoles | 2011 |
The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines.
Topics: 2-Chloroadenosine; 8-Bromo Cyclic Adenosine Monophosphate; Amines; Antineoplastic Agents; Apoptosis; Carcinoma, Neuroendocrine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; MAP Kinase Signaling System; Piperidines; Proto-Oncogene Mas; Thyroid Neoplasms | 2016 |