Page last updated: 2024-08-26

2-chloroadenine and adenine

2-chloroadenine has been researched along with adenine in 20 studies

*Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES. [MeSH]

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (35.00)	18.2507
2000's	7 (35.00)	29.6817
2010's	5 (25.00)	24.3611
2020's	1 (5.00)	2.80

Authors

Authors	Studies
Hanus, J; Havlícek, L; Leclerc, S; Meijer, L; Shaw, G; Strnad, M; Veselý, J	1
de Koning, HP; Eze, AA; Gustavsson, AL; Hammarström, LG; Lundbäck, T; Olivera, GC; Rottenberg, ME; Sjöberg, B; Svensson, R; Vodnala, SK; Yeheskieli, E	1
Carlson, EE; Goswami, M; Wilke, KE	1
Bugg, BY; Grippo, P; Hentosh, P; McCastlain, JC	1
Hentosh, P; McCastlain, JC	1
Grippo, P; Hentosh, P; Tibudan, M	1
Grippo, P; Hentosh, P	2
Albertioni, F; Liliemark, J; Lindemalm, S	1
Bontemps, F; Cardoen, S; Delacauw, A; Van Den Berghe, G; Van Den Neste, E	1
Xie, D; Xu, D; Xue, Y; Yan, G	1
Doláková, P; Holý, A; Masojídková, M	1
Albertioni, F; Juliusson, G; Larsson, R; Liliemark, J; Lindemalm, S	1
Ashton, KJ; Headrick, JP; Holmgren, K; Willems, L; Zatta, A	1
Banach, K; Bojarska, E; Bzowska, A; Kazimierczuk, Z; Magnowska, L	1
Akula, KK; Dhir, A; Kulkarni, SK	1
Davis, B; Li, P; Maguma, HT; Taylor, DA; Thayne, K	1
Kopyra, J; Kossoski, F; Varella, MT	1
Ekblom, M; Karlsson, MO; Munafo, A; Novakovic, AM; Savic, RM	1
Guo, L; Huang, Y; Li, Z; Luo, HB; Wu, XN; Wu, Y; Zheng, D; Zhou, Q	1

Trials

2 trial(s) available for 2-chloroadenine and adenine

Article	Year
Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia. Cancer letters, 2004, Jul-16, Volume: 210, Issue:2 Topics: Adenine; Administration, Oral; Area Under Curve; Humans; Infusions, Intravenous; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Tumor Cells, Cultured	2004
Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis. Clinical pharmacokinetics, 2017, Volume: 56, Issue:10 Topics: Adenine; Administration, Intravenous; Administration, Oral; Adult; Aged; Cladribine; Double-Blind Method; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Models, Biological; Multiple Sclerosis	2017

Other Studies

18 other study(ies) available for 2-chloroadenine and adenine

Article	Year
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. Journal of medicinal chemistry, 1997, Feb-14, Volume: 40, Issue:4 Topics: Animals; CDC2 Protein Kinase; CDC28 Protein Kinase, S cerevisiae; Enzyme Inhibitors; Kinetin; Oocytes; Purines; Roscovitine; Starfish; Tumor Cells, Cultured	1997
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. Journal of medicinal chemistry, 2013, Dec-27, Volume: 56, Issue:24 Topics: Animals; Cell Survival; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2013
Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases. Journal of medicinal chemistry, 2017, 10-12, Volume: 60, Issue:19 Topics: Adenine; Adenosine Triphosphate; Anti-Bacterial Agents; Aspartic Acid; Bacteria; Drug Design; Histidine Kinase; HSP90 Heat-Shock Proteins; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship	2017
Polymerase chain reaction amplification of single-stranded DNA containing a base analog, 2-chloradenine. Analytical biochemistry, 1992, Volume: 201, Issue:2 Topics: Adenine; Base Sequence; DNA; DNA, Single-Stranded; Molecular Sequence Data; Polymerase Chain Reaction	1992
Effects of 2-chloroadenine substitution in DNA on restriction endonuclease cleavage reactions. Nucleic acids research, 1991, Jun-11, Volume: 19, Issue:11 Topics: Adenine; Autoradiography; Base Sequence; DNA; DNA Restriction Enzymes; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Nucleic Acid Heteroduplexes	1991
A human factor that recognizes DNA substituted with 2-chloroadenine, an antileukemic purine analog. Molecular carcinogenesis, 1995, Volume: 13, Issue:4 Topics: Adenine; Base Sequence; DNA Damage; DNA Repair; DNA-Binding Proteins; HeLa Cells; Humans; In Vitro Techniques; Molecular Sequence Data; Nuclear Proteins; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Xeroderma Pigmentosum	1995
Template 2-chloro-2'-deoxyadenosine monophosphate inhibits in vitro DNA synthesis. Molecular pharmacology, 1994, Volume: 45, Issue:5 Topics: Adenine; Bacteriophage M13; Base Sequence; Cladribine; Deoxyribonucleotides; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Humans; Molecular Sequence Data; Templates, Genetic	1994
2-Chloro-2'-deoxyadenosine monophosphate residues in DNA enhance susceptibility to 3'-->5' exonucleases. The Biochemical journal, 1994, Sep-01, Volume: 302 ( Pt 2) Topics: Adenine; Base Sequence; Cladribine; DNA; DNA Nucleotidyltransferases; DNA Polymerase I; DNA Polymerase II; DNA-Directed DNA Polymerase; Escherichia coli; Exodeoxyribonucleases; Molecular Sequence Data; Molecular Weight; Viral Proteins	1994
Stability and analysis of 2-chloro-2'-deoxyadenosine, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine and 2-chloroadenine in human blood plasma. Anti-cancer drugs, 1997, Volume: 8, Issue:5 Topics: Adenine; Adenine Nucleotides; Aged; Antineoplastic Agents; Arabinonucleosides; Chromatography, High Pressure Liquid; Cladribine; Clofarabine; Female; Humans; Male; Middle Aged; Reproducibility of Results; Spectrophotometry, Ultraviolet	1997
Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine. Biochemical pharmacology, 2000, May-15, Volume: 59, Issue:10 Topics: Adenine; Antineoplastic Agents; Cladribine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Nucleotides; Tritium; Tumor Cells, Cultured	2000
Density functional theory studies on tautomeric stability and infrared spectra of 2-chloroadenine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2000, Volume: 56A, Issue:10 Topics: Adenine; Drug Stability; Models, Chemical; Molecular Conformation; Spectrophotometry, Infrared	2000
Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids. Nucleosides, nucleotides & nucleic acids, 2003, Volume: 22, Issue:12 Topics: 2-Aminopurine; Adenine; Antineoplastic Agents; Antiviral Agents; Butyrates; Guanine; Hypoxanthines; Lactic Acid; Magnetic Resonance Spectroscopy; Molecular Structure; Purines	2003
Age-related changes in ischemic tolerance in male and female mouse hearts. Journal of molecular and cellular cardiology, 2005, Volume: 38, Issue:2 Topics: Adenine; Adenosine Diphosphate; Aging; Animals; Collagen; Coronary Vessels; Female; Heart; Hydro-Lyases; Male; Mice; Mice, Inbred C57BL; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Sex Characteristics	2005
Kinetic model of oxidation catalyzed by xanthine oxidase-the final enzyme in degradation of purine nucleosides and nucleotides. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Topics: Adenine; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Models, Theoretical; Oxygen; Purine Nucleosides; Regression Analysis; Xanthine; Xanthine Oxidase	2005
Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. Epilepsy research, 2008, Volume: 78, Issue:1 Topics: Adenine; Adenosine; Analysis of Variance; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Lactones; Male; Mice; Pentylenetetrazole; Seizures; Sulfones	2008
Correlation of the time course of development and decay of tolerance to morphine with alterations in sodium pump protein isoform abundance. Biochemical pharmacology, 2010, Apr-01, Volume: 79, Issue:7 Topics: Adenine; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Guinea Pigs; Male; Morphine; Myenteric Plexus; Protein Isoforms; Sodium-Potassium-Exchanging ATPase; Weight Gain	2010
Anion states and fragmentation of 2-chloroadenine upon low-energy electron collisions. Physical chemistry chemical physics : PCCP, 2015, Nov-21, Volume: 17, Issue:43 Topics: Adenine; Anions; Electrons; Hydrogen; Quantum Theory	2015
Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. Journal of medicinal chemistry, 2020, 12-24, Volume: 63, Issue:24 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Administration, Oral; Animals; Behavior, Animal; Binding Sites; Crystallography, X-Ray; Dementia, Vascular; Disease Models, Animal; Drug Design; Half-Life; Humans; Inhibitory Concentration 50; Isoenzymes; Mice; Molecular Dynamics Simulation; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2020