Page last updated: 2024-09-03

2-chloro-n(6)cyclopentyladenosine and phenylisopropyladenosine

2-chloro-n(6)cyclopentyladenosine has been researched along with phenylisopropyladenosine in 7 studies

Compound Research Comparison

Studies
(2-chloro-n(6)cyclopentyladenosine)
Trials
(2-chloro-n(6)cyclopentyladenosine)
Recent Studies (post-2010)
(2-chloro-n(6)cyclopentyladenosine)
Studies
(phenylisopropyladenosine)
Trials
(phenylisopropyladenosine)
Recent Studies (post-2010) (phenylisopropyladenosine)
25204363010

Protein Interaction Comparison

ProteinTaxonomy2-chloro-n(6)cyclopentyladenosine (IC50)phenylisopropyladenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)1.8613
Adenosine receptor A1Rattus norvegicus (Norway rat)0.0294
Adenosine receptor A3Rattus norvegicus (Norway rat)0.0497
Adenosine receptor A2bRattus norvegicus (Norway rat)0.2898
Adenosine receptor A1Homo sapiens (human)0.83
Adenosine receptor A2aRattus norvegicus (Norway rat)0.2898

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jacobson, KA; van Galen, PJ; Williams, M1
Daly, JW; Olsson, RA; Secunda, S; Thompson, RD1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L1
Barbhaiya, H; IJzerman, AP; Rivkees, SA1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T1
Barak, D; Biadatti, T; Chen, W; Gao, ZG; Jacobson, KA; Johnson, CR; Kim, SG; Kim, SK; Lee, K1

Reviews

1 review(s) available for 2-chloro-n(6)cyclopentyladenosine and phenylisopropyladenosine

ArticleYear
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship

1992

Other Studies

6 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and phenylisopropyladenosine

ArticleYear
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:12

    Topics: 2-Chloroadenosine; Animals; Brain; In Vitro Techniques; Rats; Receptors, Purinergic; Structure-Activity Relationship

1991
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines

1998
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
    Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis

1998
Identification of the adenine binding site of the human A1 adenosine receptor.
    The Journal of biological chemistry, 1999, Feb-05, Volume: 274, Issue:6

    Topics: Adenine; Amides; Amino Acid Sequence; Amino Acids; Binding Sites; DNA, Complementary; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Purinergic P1

1999
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
    Molecular pharmacology, 1999, Volume: 56, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines

1999
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
    Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20

    Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Epoxy Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ribose; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship

2002