2-chloro-n(6)cyclopentyladenosine and n(6)-cyclopentyladenosine

2-chloro-n(6)cyclopentyladenosine has been researched along with n(6)-cyclopentyladenosine in 24 studies

Compound Research Comparison

Studies (2-chloro-n(6)cyclopentyladenosine)	Trials (2-chloro-n(6)cyclopentyladenosine)	Recent Studies (post-2010) (2-chloro-n(6)cyclopentyladenosine)	Studies (n(6)-cyclopentyladenosine)	Trials (n(6)-cyclopentyladenosine)	Recent Studies (post-2010) (n(6)-cyclopentyladenosine)
252	0	43	605	0	62

Protein Interaction Comparison

Protein	Taxonomy	n(6)-cyclopentyladenosine (IC50)
Adenosine receptor A1	Rattus norvegicus (Norway rat)	0.2256
Adenosine receptor A2b	Rattus norvegicus (Norway rat)	1.16
Adenosine receptor A1	Homo sapiens (human)	0.0027
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	1.16

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (33.33)	18.2507
2000's	11 (45.83)	29.6817
2010's	4 (16.67)	24.3611
2020's	1 (4.17)	2.80

Authors

Authors	Studies
Jacobson, KA; van Galen, PJ; Williams, M	1
Daly, JW; Olsson, RA; Secunda, S; Thompson, RD	1
Jacobson, KA; Ji, XD; Kim, HO; Olah, ME; Siddiqi, SM; Stiles, GL	1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C	1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L	1
Barbhaiya, H; IJzerman, AP; Rivkees, SA	1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T	1
Costanzi, S; Cristalli, G; IJzerman, AP; Kunzel, JK; Lorenzen, A; Stannek, C; Vittori, S; Volpini, R	1
Jacobson, KA; Ji, X; Li, AH; Marquez, VE; Melman, N; Ravi, RG; Shin, KJ; Siddiqui, MA	1
de Groote, M; IJzerman, AP; Lorenzen, A; Stannek, C; van der Klein, PA; van Tilburg, EW; von Frijtag Drabbe Künzel, J	1
Barak, D; Biadatti, T; Chen, W; Gao, ZG; Jacobson, KA; Johnson, CR; Kim, SG; Kim, SK; Lee, K	1
Duong, HT; Gao, ZG; Jacobson, KA; Joshi, BV; Liang, BT; Sonin, D; Tchilibon, S	1
Gao, ZG; Jacobson, KA	1
Cappellacci, L; Costa, B; Franchetti, P; Grifantini, M; Klotz, KN; Lavecchia, A; Martini, C; Petrelli, R; Spinetti, F; Vita, P	1
Cappellacci, L; Franchetti, P; Graser, G; Grifantini, M; Jayaram, HN; Lavecchia, A; Petrelli, R; Saiko, P; Szekeres, T; Vita, P	1
Coleman, J; Fitzpatrick, BJ; Frye, SV; Hull-Ryde, EA; Janzen, WP; Jin, J; Korboukh, I; Randhawa, AS; Rittiner, JE; Setola, V; Zylka, MJ	1
Deflorian, F; Gao, ZG; Jacobson, KA; Jiang, X; Moss, SM; Paoletta, S; Phan, K; Tosh, DK	1
Amin, EA; Dosa, PI	1
Auchampach, JA; Bitant, A; Ciancetta, A; Cui, Z; Gao, ZG; Gavrilova, O; Jacobson, KA; Lieberman, DI; Liu, N; Mannes, P; Mattison, JA; Rao, H; Reitman, ML; Rothwell, AC; Salmaso, V; Tosh, DK; Vaughan, KL	1
Antonelli, MC; Giraldez, L; Girardi, E; Rodríguez de Lores Arnaiz, G; Zanetti, F	1
Hashimoto, K; Iyo, M; Komatsu, N; Kumakiri, C; Okamura, N; Shimizu, E	1
Aqvist, J; Centeno, NB; Gutiérrez-de-Terán, H; Pastor, M; Sanz, F	1
Cao, Y; Jin, L; Meng, F; Sun, WC; Wang, LZ; Zhu, XZ	1
Langston, JL; Meads, KL; Myers, TM; Shih, TM; Thomas, TP	1

Reviews

3 review(s) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-cyclopentyladenosine

Article	Year
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship	1992
Adenosine receptors as therapeutic targets. Nature reviews. Drug discovery, 2006, Volume: 5, Issue:3 Topics: Animals; Disease; Drug Therapy; Humans; Ligands; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Structure-Activity Relationship	2006
Tactical Approaches to Interconverting GPCR Agonists and Antagonists. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Animals; Humans; Ligands; Models, Molecular; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2016

Other Studies

21 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-cyclopentyladenosine

Article	Year
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. Journal of medicinal chemistry, 1991, Volume: 34, Issue:12 Topics: 2-Chloroadenosine; Animals; Brain; In Vitro Techniques; Rats; Receptors, Purinergic; Structure-Activity Relationship	1991
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	1994
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines	1998
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis	1998
Identification of the adenine binding site of the human A1 adenosine receptor. The Journal of biological chemistry, 1999, Feb-05, Volume: 274, Issue:6 Topics: Adenine; Amides; Amino Acid Sequence; Amino Acids; Binding Sites; DNA, Complementary; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Purinergic P1	1999
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines	1999
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor. Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2 Topics: Adenosine; Animals; Brain; Guanosine 5'-O-(3-Thiotriphosphate); Magnetic Resonance Spectroscopy; Phenethylamines; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Tubercidin; Xanthines	2000
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Purine Nucleosides; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Sulfur Radioisotopes	2000
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors. Journal of medicinal chemistry, 2001, Aug-30, Volume: 44, Issue:18 Topics: Adenosine; Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Cricetinae; Cyclic AMP; Humans; In Vitro Techniques; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Structure-Activity Relationship	2001
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20 Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Epoxy Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ribose; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2002
Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. Journal of medicinal chemistry, 2005, Dec-29, Volume: 48, Issue:26 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A3 Receptor Agonists; Animals; Cardiotonic Agents; CHO Cells; Cricetinae; Drug Design; Humans; Mice; Myocardial Infarction; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Ventricular Function, Left	2005
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. Bioorganic & medicinal chemistry, 2008, Jan-01, Volume: 16, Issue:1 Topics: Adenosine A1 Receptor Agonists; Animals; Carbamates; Cattle; Computer Simulation; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Protein Binding; Purine Nucleosides; Static Electricity; Structure-Activity Relationship; Swine	2008
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives. Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14 Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Humans; Ribonucleotide Reductases; Ribose; Structure-Activity Relationship	2008
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14 Topics: Adenosine A1 Receptor Agonists; Adenosine Monophosphate; Administration, Oral; Analgesics; Animals; Behavior, Animal; HEK293 Cells; Humans; Male; Mice; Nociception; Receptor, Adenosine A1; Substrate Specificity; Temperature	2012
Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity. Journal of medicinal chemistry, 2012, Sep-27, Volume: 55, Issue:18 Topics: Animals; Anticonvulsants; CHO Cells; Cricetinae; Cricetulus; Humans; Male; Mice; Molecular Docking Simulation; Nucleosides; Protein Conformation; Receptor, Adenosine A1; Structure-Activity Relationship	2012
Design and in Vivo Characterization of A Journal of medicinal chemistry, 2019, 02-14, Volume: 62, Issue:3 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Bridged Bicyclo Compounds; CHO Cells; Cricetulus; Drug Design; HEK293 Cells; Humans; Macaca fascicularis; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Receptor, Adenosine A1; Structure-Activity Relationship	2019
CNS adenosine A1 receptors are altered after the administration of convulsant 3-mercaptopropionic acid and cyclopentyladenosine: an autoradiographic study. Neurochemical research, 1998, Volume: 23, Issue:2 Topics: 3-Mercaptopropionic Acid; Adenosine; Animals; Anticonvulsants; Autoradiography; Brain; Convulsants; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Receptors, Purinergic P1	1998
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:3 Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; HSP70 Heat-Shock Proteins; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate	2004
Comparative analysis of putative agonist-binding modes in the human A1 adenosine receptor. Chembiochem : a European journal of chemical biology, 2004, Jun-07, Volume: 5, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Binding Sites; Humans; Mathematics; Models, Molecular; Receptor, Adenosine A1; Thermodynamics	2004
Modulating effect of adenosine deaminase on function of adenosine A1 receptors. Acta pharmacologica Sinica, 2005, Volume: 26, Issue:2 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Calcium; Cell Line; Cell Membrane; Embryo, Mammalian; Humans; Kidney; Radioligand Assay; Receptor, Adenosine A1; Signal Transduction; Xanthines	2005
Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and applied pharmacology, 2021, 04-01, Volume: 416 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Behavior, Animal; Brain; Deoxyadenosines; Disease Models, Animal; Male; Neuroprotective Agents; Organophosphate Poisoning; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Soman	2021