Page last updated: 2024-09-03

2-chloro-n(6)cyclopentyladenosine and n(6)-cyclohexyladenosine

2-chloro-n(6)cyclopentyladenosine has been researched along with n(6)-cyclohexyladenosine in 10 studies

Compound Research Comparison

Studies
(2-chloro-n(6)cyclopentyladenosine)
Trials
(2-chloro-n(6)cyclopentyladenosine)
Recent Studies (post-2010)
(2-chloro-n(6)cyclopentyladenosine)
Studies
(n(6)-cyclohexyladenosine)
Trials
(n(6)-cyclohexyladenosine)
Recent Studies (post-2010) (n(6)-cyclohexyladenosine)
252043555033

Protein Interaction Comparison

ProteinTaxonomy2-chloro-n(6)cyclopentyladenosine (IC50)n(6)-cyclohexyladenosine (IC50)
Adenosine receptor A1Rattus norvegicus (Norway rat)0.0024
Adenosine receptor A3Rattus norvegicus (Norway rat)0.0024
Adenosine receptor A2bRattus norvegicus (Norway rat)0.588
Adenosine receptor A2aRattus norvegicus (Norway rat)0.588
Adenosine receptor A1Gallus gallus (chicken)0.0025

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (70.00)18.2507
2000's3 (30.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jacobson, KA; van Galen, PJ; Williams, M1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L1
Costanzi, S; Cristalli, G; IJzerman, AP; Kunzel, JK; Lorenzen, A; Stannek, C; Vittori, S; Volpini, R1
Cappellacci, L; Franchetti, P; Graser, G; Grifantini, M; Jayaram, HN; Lavecchia, A; Petrelli, R; Saiko, P; Szekeres, T; Vita, P1
Lucchi, R; Poli, A; Rosati, AM; Traversa, U1
Hirawa, N; Ishii, M; Iwamoto, T; Kihara, M; Takagi, N; Toya, Y; Umemura, S1
Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K1
de Jong, JW; de Jonge, R1
Rosati, AM; Traversa, U1
Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR1

Reviews

2 review(s) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-cyclohexyladenosine

ArticleYear
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Adenosine; Animals; Humans; Models, Chemical; Receptors, Purinergic; Second Messenger Systems; Structure-Activity Relationship

1992
Ischemic preconditioning--do we need more (pharmacological) experiments?
    Basic research in cardiology, 1997, Volume: 92 Suppl 2

    Topics: Adenosine; Animals; Blood Flow Velocity; Bradykinin; Coronary Vessels; Humans; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Norepinephrine; Purinergic P1 Receptor Agonists

1997

Other Studies

8 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-cyclohexyladenosine

ArticleYear
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
    Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis

1998
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
    Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2

    Topics: Adenosine; Animals; Brain; Guanosine 5'-O-(3-Thiotriphosphate); Magnetic Resonance Spectroscopy; Phenethylamines; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Tubercidin; Xanthines

2000
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Humans; Ribonucleotide Reductases; Ribose; Structure-Activity Relationship

2008
Biochemical and pharmacological evidence for the presence of A1 but not A2a adenosine receptors in the brain of the low vertebrate teleost Carassius auratus (goldfish).
    Neurochemistry international, 1995, Volume: 26, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Goldfish; Hydrogen-Ion Concentration; Mammals; Neurotransmitter Agents; Phenethylamines; Radioligand Assay; Receptors, Purinergic P1; Species Specificity; Temperature

1995
Identification and characterization of adenosine A1 receptor-cAMP system in human glomeruli.
    Kidney international, 1993, Volume: 43, Issue:4

    Topics: Adenosine; Binding, Competitive; Cyclic AMP; Humans; In Vitro Techniques; Kidney Glomerulus; Kinetics; Radioligand Assay; Receptors, Purinergic; Xanthines

1993
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines

1997
Mechanisms of inhibitory effects of zinc and cadmium ions on agonist binding to adenosine A1 receptors in rat brain.
    Biochemical pharmacology, 1999, Aug-15, Volume: 58, Issue:4

    Topics: Adenosine; Amino Acids, Sulfur; Animals; Binding, Competitive; Brain; Cadmium; Culture Media; Diethyl Pyrocarbonate; Dithionitrobenzoic Acid; Dithiothreitol; Histidine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Sulfhydryl Compounds; Sulfhydryl Reagents; Tritium; Zinc

1999
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 368, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles

2003