Compounds > 2-chloro-n(6)cyclopentyladenosine
Page last updated: 2024-09-03

2-chloro-n(6)cyclopentyladenosine and n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine

2-chloro-n(6)cyclopentyladenosine has been researched along with n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine in 14 studies

Compound Research Comparison

Studies
(2-chloro-n(6)cyclopentyladenosine)		Trials
(2-chloro-n(6)cyclopentyladenosine)		Recent Studies (post-2010)
(2-chloro-n(6)cyclopentyladenosine)		Studies
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Trials
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Recent Studies (post-2010) (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)
252043214558

Protein Interaction Comparison

ProteinTaxonomy2-chloro-n(6)cyclopentyladenosine (IC50)n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)2.1002
Adenosine receptor A3Homo sapiens (human)0.0017

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (42.86)18.2507
2000's6 (42.86)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jacobson, KA; Ji, XD; Kim, HO; Olah, ME; Siddiqi, SM; Stiles, GL1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T1
Barak, D; Biadatti, T; Chen, W; Gao, ZG; Jacobson, KA; Johnson, CR; Kim, SG; Kim, SK; Lee, K1
Gao, ZG; Jacobson, KA1
Amin, EA; Dosa, PI1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J1
Haskó, G; Kvetan, V; Németh, ZH; Pastores, SM; Szabó, C; Vizi, ES1
Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K1
Fujita, M; Ito, H; Kohno, Y; Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Toyota, T1
Auchampach, JA; Bhattacharya, S; Black, RG; Bolli, R; Kodani, E; Takano, H; Tang, XL; Yang, Z1
de Zeeuw, S; Duncker, DJ; Liem, DA; van den Doel, MA; Verdouw, PD1
Alhaj, M; Bozarov, A; Christofi, FL; Cooke, HJ; Grants, I; Hassanain, HH; Ren, T; Wang, YZ; Wunderlich, J; Yu, JG1

Reviews

2 review(s) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine

ArticleYear
Adenosine receptors as therapeutic targets.
    Nature reviews. Drug discovery, 2006, Volume: 5, Issue:3

    Topics: Animals; Disease; Drug Therapy; Humans; Ligands; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Structure-Activity Relationship

2006
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Animals; Humans; Ligands; Models, Molecular; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2016

Other Studies

12 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine

ArticleYear
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship

1994
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines

1998
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
    Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis

1998
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
    Molecular pharmacology, 1999, Volume: 56, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines

1999
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
    Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20

    Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Epoxy Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ribose; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship

2002
Polypharmacology of N
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3

2017
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.
    Journal of immunology (Baltimore, Md. : 1950), 1996, Nov-15, Volume: 157, Issue:10

    Topics: Adenosine; Animals; Endotoxemia; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha

1996
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines

1997
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats.
    Gastroenterology, 2000, Volume: 119, Issue:3

    Topics: Acute Disease; Adenosine; Amylases; Animals; Ceruletide; Edema; Leukocytes; Male; Pancreas; Pancreatic Diseases; Pancreatitis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Taurocholic Acid

2000
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.
    Circulation research, 2001, Mar-16, Volume: 88, Issue:5

    Topics: Adenine; Adenosine; Animals; Binding, Competitive; Cell Line; Consciousness; Decanoic Acids; Humans; Hydroxy Acids; Iodine Radioisotopes; Ischemic Preconditioning, Myocardial; Membranes; Myocardial Infarction; Nitroarginine; Norbornanes; Phenethylamines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1

2001
Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.
    Cardiovascular research, 2001, Volume: 51, Issue:4

    Topics: Acetamides; Adenosine; Analysis of Variance; Animals; Cryoprotective Agents; Dihydropyridines; Histamine H1 Antagonists; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Wistar; Receptors, Purinergic; Receptors, Purinergic P1; Theophylline; Time Factors

2001
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:6

    Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Intestinal Secretions; Male; Mecamylamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neural Inhibition; Neurogenic Bowel; Neurokinin-1 Receptor Antagonists; Nicotinic Antagonists; Piperidines; Propane; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Histamine H2; Receptors, Neurokinin-1; Reflex; Theophylline; Xanthines

2009