2-chloro-n(6)cyclopentyladenosine has been researched along with adenosine in 211 studies
| Studies (2-chloro-n(6)cyclopentyladenosine) | Trials (2-chloro-n(6)cyclopentyladenosine) | Recent Studies (post-2010) (2-chloro-n(6)cyclopentyladenosine) | Studies (adenosine) | Trials (adenosine) | Recent Studies (post-2010) (adenosine) |
|---|---|---|---|---|---|
| 252 | 0 | 43 | 32,536 | 1,075 | 8,930 |
| Protein | Taxonomy | 2-chloro-n(6)cyclopentyladenosine (IC50) | adenosine (IC50) |
|---|---|---|---|
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | 0.3851 | |
| Sodium/nucleoside cotransporter 1 | Homo sapiens (human) | 5.5 | |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | 5.5 | |
| Adenosine receptor A3 | Homo sapiens (human) | 0.0011 | |
| Adenosine receptor A1 | Homo sapiens (human) | 0.0023 | |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | 63 | |
| Solute carrier family 28 member 3 | Homo sapiens (human) | 3.3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.95) | 18.7374 |
| 1990's | 88 (41.71) | 18.2507 |
| 2000's | 85 (40.28) | 29.6817 |
| 2010's | 32 (15.17) | 24.3611 |
| 2020's | 4 (1.90) | 2.80 |
| Authors | Studies |
|---|---|
| Daly, JW; Olsson, RA; Secunda, S; Thompson, RD | 1 |
| Jacobson, KA; Ji, X; Li, AH; Marquez, VE; Melman, N; Ravi, RG; Shin, KJ; Siddiqui, MA | 1 |
| Coleman, J; Fitzpatrick, BJ; Frye, SV; Hull-Ryde, EA; Janzen, WP; Jin, J; Korboukh, I; Randhawa, AS; Rittiner, JE; Setola, V; Zylka, MJ | 1 |
| Dowell, SJ; Frattini, E; Frenguelli, BG; Hemmings, JL; Knight, A; Ladds, G; Leuenberger, M; Lochner, M; Winfield, I | 1 |
| Downey, JM; Liu, Y | 2 |
| Klotz, KN; Lehr, HA; Lorenzen, A; Messmer, K; Nolte, D; Zimmer, FJ | 1 |
| Downey, JM; Liu, GS; Olsson, RA; Thornton, JD | 1 |
| Mullane, K | 1 |
| Klotz, KN; Schwabe, U; Tawfik-Schlieper, H; Wilken, A | 1 |
| Cristalli, G; Grifantini, M; Klotz, KN; Lohse, MJ; Schwabe, U; Vittori, S | 2 |
| Armstrong, S; Downey, JM; Ganote, CE | 2 |
| Amoroso, S; Annunziato, L; Di Renzo, G; Iannotti, E; Saggese, ML | 1 |
| Lucchi, R; Poli, A; Rosati, AM; Traversa, U | 1 |
| Barbhaiya, H; Lasbury, ME; Rivkees, SA | 1 |
| Chouker, A; Thiel, M | 1 |
| Bonizzoni, E; Casati, C; Milani, S; Monopoli, A; Ongini, E | 1 |
| Aguilar, JS; Durand, I; Green, RD; Tan, F | 1 |
| Lasley, RD; Mentzer, RM; Noble, MA; Paulsen, KL | 1 |
| Banerjee, A; Bensard, DD; Brew, EC; Fullerton, DA; Hahn, AR; McIntyre, RC | 1 |
| Bellingham, MC; Berger, AJ | 1 |
| Schiele, JO; Schwabe, U | 1 |
| Borchard, U; Felsch, A; Stöcker, K | 1 |
| Camaioni, E; Casati, C; Conti, A; Cristalli, G; Dionisotti, S; Monopoli, A; Ongini, E | 1 |
| Christofi, FL; Wood, JD | 2 |
| Boyet, S; Daval, JL; Nehlig, A | 1 |
| Driessen, B; Starke, K; von Kügelgen, I | 1 |
| Biggio, G; Concas, A; Cuccheddu, T; Floris, S; Mascia, MP | 1 |
| Chintala, M; Chiu, PJ; Dionisotti, S; Ongini, E; Sandoli, D | 1 |
| Baxter, GF; Marber, MS; Patel, VC; Yellon, DM | 1 |
| Downey, JM; Olsson, RA; Thompson, R; Tsuchida, A | 1 |
| Daval, JL; Koziel, V; Nicolas, F; Oillet, J | 1 |
| Conti, A; Dionisotti, S; Gatta, F; Ongini, E; Sandoli, D; Zocchi, C | 1 |
| Bonizzoni, E; Casati, C; Dionisotti, S; Monopoli, A; Ongini, E; Zocchi, C | 1 |
| Biggio, G; Concas, A; Dazzi, L; Maciocco, E; Mascia, MP; Ongini, E; Santoro, G | 1 |
| Downey, JM; Liu, GS; Tsuchida, A; Wilborn, WH | 1 |
| Borea, PA; Conti, A; Gamba, M; Monopoli, A; Ongini, E | 1 |
| Hirawa, N; Ishii, M; Iwamoto, T; Kihara, M; Takagi, N; Toya, Y; Umemura, S | 1 |
| Adkins, WK; Allison, RC; Barnard, JW; Moore, TM; Prasad, VR; Taylor, AE | 1 |
| Keil, R; Lorenzen, A; Matias, A; Schwabe, U; Zimmer, FJ | 1 |
| Daval, JL; Nicolas, F | 2 |
| Baker, SP; Belardinelli, L; Dennis, D; Milner, P; Olsson, R; Pfister, J; Scammells, PJ; Shryock, JC; Zhang, Y | 1 |
| Bottrill, FE; Hiley, CR; Richardson, PJ; Warnock, J | 1 |
| Kleppisch, T; Nelson, MT | 1 |
| Ballerini, P; Battaglia, G; Caciagli, F; Ciccarelli, R; Di Iorio, P; Giuliani, P; Nicoletti, F; Poli, A | 1 |
| Adami, M; Bertorelli, R; Ferri, N; Foddi, MC; Ongini, E | 1 |
| Armstrong, SC; Ganote, CE; Rice, PJ | 1 |
| Biggio, G; Concas, A; Cuccheddu, T; Floris, S; Mascia, MP; Mostallino, MC; Perra, C; Satta, S | 1 |
| Kaneko, S; Mizuno, K; Okada, M | 1 |
| Busca, G; Castoldi, G; Genovesi, S; Golin, R; Panzacchi, G; Protasoni, G; Stella, A | 1 |
| Haskó, G; Kvetan, V; Németh, ZH; Pastores, SM; Szabó, C; Vizi, ES | 1 |
| De Sarro, A; De Sarro, G; Donato Di Paola, E; Falconi, U; Ferreri, G | 1 |
| Florio, C; Rosati, AM; Traversa, U; Vertua, R | 1 |
| Baxter, GF; Kerac, M; Yellon, DM; Zaman, MJ | 1 |
| Casati, C; Forlani, A; Lozza, G; Monopoli, A | 1 |
| Conti, A; Lozza, G; Monopoli, A; Ongini, E | 1 |
| Dixon, AK; Richardson, PJ; Widdowson, L | 1 |
| Baxter, GF; Yellon, DM | 1 |
| Davies, CH; Morton, RA | 1 |
| Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K | 1 |
| Falcón, J; Privat, K; Ravault, JP | 1 |
| de Jong, JW; de Jonge, R | 2 |
| Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C | 1 |
| Antonelli, MC; Giraldez, L; Girardi, E; Rodríguez de Lores Arnaiz, G; Zanetti, F | 1 |
| Dobson, JG; Fenton, RA; Sawmiller, DR | 1 |
| Busca, G; Demarchi, B; Golin, R; Panzacchi, G; Protasoni, G; Stella, A | 1 |
| Edwards, FA; Robertson, SJ | 1 |
| Falcón, J; Lelièvre, V; Muller, JM | 1 |
| Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L | 1 |
| Coney, AM; Marshall, JM | 1 |
| Florio, C; Papaioannou, A; Prezioso, A; Vertua, R | 1 |
| Lasley, RD; Mentzer, RM; Narayan, P; Valdivia, HH | 1 |
| Baker, SP; Baraldi, PG; Belardinelli, L; Cacciari, B; Monopoli, A; Ongini, E; Shryock, JC; Snowdy, S; Spalluto, G | 1 |
| Fujishima, M; Goda, H; Ibayashi, S; Nakane, H; Ooboshi, H; Sadoshima, S | 1 |
| Bryan, PT; Marshall, JM | 2 |
| Borsello, T; Calissano, P; Ciotti, MT; Galli, C; Vitolo, OV | 1 |
| Cutler, BS; Dobson, JG; Fenton, RA; Li, Jm; Peyton, BD; Powell, CC; Wheeler, HB | 1 |
| Kaneko, S; Okada, M | 1 |
| Kaneko, S; Kawata, Y; Kondo, T; Mizuno, K; Murakami, T; Okada, M; Wada, K | 1 |
| Akahane, A; Butcher, SP; Finlayson, K; Ito, H; Maemoto, T; Olverman, HJ | 1 |
| Bagley, EE; Christie, MJ; Vaughan, CW | 1 |
| Jurklies, B; Kaelin-Lang, A; Niemeyer, G | 1 |
| Bernardo, NL; Kukreja, RC; Maaieh, MM; Okubo, S; Wood, MA | 1 |
| Rosati, AM; Traversa, U | 1 |
| Battaglia, G; Bruno, V; Caciagli, F; Ciccarelli, R; D'Alimonte, I; D'Onofrio, M; Di Iorio, P; Nicoletti, F | 1 |
| Hara, A; Ito, Z; Kusakari, J; Tabuchi, K; Takahashi, K; Wada, T | 1 |
| Davie, CS; Everitt, DE; Standen, NB | 1 |
| Håberg, A; Haraldseth, O; Qu, H; Sonnewald, U; Unsgård, G | 1 |
| Song, WJ; Surmeier, DJ; Tkatch, T | 1 |
| Lasley, RD; Mentzer, RM; Narayan, P | 2 |
| Lasley, RD; Narayan, P; Smart, EJ; Uittenbogaard, A | 1 |
| Fletcher, DS; Jacobson, MA; Koller, BH; Latour, AM; Salvatore, CA; Tilley, SL | 1 |
| Camisasca, P; Genovesi, S; Golin, R; Pieruzzi, F; Protasoni, G; Ragonesi, G; Stella, A; Zanchetti, A | 1 |
| Ballanyi, K; Brockhaus, J | 1 |
| Starodub, AM; Wood, JD | 1 |
| Aoki, M; Narimatsu, E | 1 |
| Dana, A; Jonassen, AK; Yamashita, N; Yellon, DM | 1 |
| Arai, M; Lemasters, JJ; Thurman, RG | 1 |
| Chelliah, J; Kukreja, RC; Levasseur, JE; Xi, L; Zhao, T | 1 |
| Fujita, M; Ito, H; Kohno, Y; Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Toyota, T | 1 |
| Beraudi, A; Di Iorio, P; Notari, S; Poli, A; Traversa, U; Villani, L; Zaccanti, F | 1 |
| Brodmann, M; Lueger, A; Stark, G; Stark, U | 1 |
| Burgdorf, C; Jain, D; Katus, HA; Kurz, T; Richardt, D; Richardt, G; Seyfarth, M | 1 |
| Bradamante, S; de Jong, JW; de Jonge, R; Giacometti, D | 1 |
| Doering, A; Middlekauff, HR; Weiss, JN | 1 |
| Chung, ES; Dobson, JG; Fenton, RA; Lorbar, M; Meyer, TE; Norton, GR; Perlini, S; Woodiwiss, AJ | 1 |
| Auchampach, JA; Bhattacharya, S; Black, RG; Bolli, R; Kodani, E; Takano, H; Tang, XL; Yang, Z | 1 |
| Balas, N; Jacobson, KA; Nawrath, H; Safran, N; Shainberg, A; Shneyvays, V | 1 |
| Ebinger, G; Khan, GM; Michotte, Y; Smolders, I | 1 |
| Jacobson, K; Mamedova, L; Shainberg, A; Shneyvays, V; Zinman, T | 1 |
| Baxter, GF; Dana, A; Yellon, DM | 1 |
| Giraldez, L; Girardi, E; Rodríguez de Lores Arnaiz, G; Vanore, G | 1 |
| de Zeeuw, S; Duncker, DJ; Liem, DA; van den Doel, MA; Verdouw, PD | 1 |
| Latchman, DS; Schulman, D; Yellon, DM | 1 |
| Fox, JE; French, RJ; Kanji, HD; Light, PE | 1 |
| Mo, LL; Sundström, E | 1 |
| Bonfanti, A; Marchi, M; Monopoli, A; Ongini, E; Raiteri, L; Raiteri, M; Risso, F; Vallarino, A | 1 |
| Gao, ZG; Jacobson, KA | 1 |
| Belem, PC; Chen, JF; Cronstein, B; Elson, G; Fink, JS; Jacobson, M; Leibovich, SJ; Montesinos, C; Pinhal-Enfield, G; Ramanathan, M; Rosania, A; Schwarzschild, MA | 1 |
| Ashraf, M; Ayub, A; Kudo, M; Wang, Y; Xu, M | 1 |
| Bastia, E; Bertorelli, R; Monopoli, A; Varani, K | 1 |
| Baxter, GF; Hausenloy, DJ; Maddock, HL; Yellon, DM | 1 |
| Backx, PH; Batthish, M; Diaz, RJ; Wilson, GJ; Zeng, HP | 1 |
| Boison, D; Güttinger, M; Huber, A; Möhler, H | 1 |
| Berdeaux, A; Ghaleh, B; Giudicelli, JF; Lellouche, N; Souktani, R; Tissier, R | 1 |
| Batra, VK; Wilson, CN | 1 |
| Clark, RS; Dixon, CE; Griffith, RP; Jackson, EK; Jenkins, LW; Kochanek, PM; Melick, JA; Peters, GW; Vagni, VA; Varma, MR | 1 |
| Gross, GJ; Peart, JN | 1 |
| Dobson, JG; Fenton, RA; Shea, LG | 1 |
| Hill, KJ; Hill, SJ; Webber, AC | 1 |
| Boison, D; Fritschy, JM; Gouder, N | 1 |
| Berrino, L; Capuano, A; De Novellis, V; Filippelli, A; Mazzeo, F; Rossi, F; Stella, L; Vitelli, MR | 1 |
| Butcher, SP; Finlayson, K; Maemoto, T; Olverman, HJ; Sharkey, J | 1 |
| Emala, CW; Lee, HT; Nasr, SH; Schnermann, J; Xu, H | 1 |
| Hashimoto, K; Iyo, M; Komatsu, N; Kumakiri, C; Okamura, N; Shimizu, E | 1 |
| Duchen, M; Hausenloy, D; Wynne, A; Yellon, D | 1 |
| Aqvist, J; Centeno, NB; Gutiérrez-de-Terán, H; Pastor, M; Sanz, F | 1 |
| Batista, LC; Prediger, RD; Takahashi, RN | 1 |
| Mustafa, SJ; Oldenburg, PJ; Schnermann, J; Tawfik, HE | 1 |
| Cao, Y; Jin, L; Meng, F; Sun, WC; Wang, LZ; Zhu, XZ | 1 |
| Prediger, RD; Takahashi, RN | 1 |
| Keith, BJ; Kristo, G; Lasley, RD; Mentzer, RM; Yoshimura, Y | 1 |
| Cristalli, G; Morelli, M; Pinna, A; Volpini, R | 1 |
| Bolli, R; Guo, Y; Li, Q; Stein, AB; Tan, W; Wu, WJ; Zhu, X | 1 |
| Canyon, SJ; Dobson, GP | 1 |
| Dobson, JG; Fenton, RA; Tikh, EI | 1 |
| Eisemann, C; Roewer, N; Tas, PW | 1 |
| Kehl, F; Lange, M; Roewer, N | 1 |
| Cao, Y; Xie, KQ; Zhu, XZ | 1 |
| Greengard, P; Higashi, H; Kuroiwa, M; Nishi, A; Shuto, T; Snyder, GL; Sotogaku, N; Tanaka, M; Yabuuchi, K | 1 |
| Cassone, JJ; De Lorenzo, S; Losavio, AS; Muchnik, S; Veggetti, MI | 1 |
| Bardenheuer, HJ; Heller, AR; Koch, T; Plaschke, K; Rothermel, J; Schmeck, J; Weigand, MA; Wendel, M | 1 |
| Ozacmak, VH; Sayan, H | 1 |
| Cappellacci, L; de Novellis, V; Franchetti, P; Grifantini, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Stella, L; Vita, D | 1 |
| Aiba, A; Fredholm, BB; Hashimoto, K; Hashimotodani, Y; Kano, M; Kassai, H; Kawakami, D; Sekino, Y; Tabata, T; Yoshida, T | 1 |
| Dobrowolski, L; Kompanowska-Jezierska, E; Sadowski, J; Walkowska, A | 1 |
| Cheporko, Y; Hochhauser, E; Kaminski, O; Leshem, D; Shainberg, A; Vidne, BA | 1 |
| Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J | 1 |
| Ajamieh, HH; Berlanga, J; Carmona, AM; León Fernández, OS; Menéndez, S; Re, L; Viebahn-Hánsler, R | 1 |
| Ballard-Croft, C; Keith, BJ; Lasley, RD; Locklar, AC; Mentzer, RM | 1 |
| Carneiro, FS; Carneiro, ZN; Giachini, FRC; Inscho, EW; Leite, R; Lima, VV; Tostes, RC; Webb, RC | 1 |
| Bichler, Z; Cosnay, P; del Rio, JA; Gannier, FE; Hivert, B; Lignon, JM; Malécot, CO; Migliore-Samour, D | 1 |
| Ajamieh, HH; Candelario-Jalil, E; Fernández, OS; Gerbes, AL | 1 |
| Braden, BB; Butler, TR; Prendergast, MA; Self, RL; Smith, KJ | 1 |
| Kawamata, M; Namiki, A; Narimatsu, E; Niiya, T | 1 |
| Dobson, JG; Fenton, RA; Ikebe, M; Komatsu, S; Shea, LG | 2 |
| Anand-Srivastava, MB; Balakumar, P; Reddy, K; Singh, H | 1 |
| Chang, Y; Liu, J; Ran, K; Xie, C; Xu, J | 1 |
| Alhaj, M; Bozarov, A; Christofi, FL; Cooke, HJ; Grants, I; Hassanain, HH; Ren, T; Wang, YZ; Wunderlich, J; Yu, JG | 1 |
| McGuirk, SR; Pardee, AL; Pritchett, CE; Will, MJ | 1 |
| Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y | 1 |
| Hu, K; Sun, W; Yang, Z | 1 |
| Guo, CX; Gupta, R; Housley, GD; Thorne, PR; Vlajkovic, SM; Wong, AC | 1 |
| Mustafa, SJ; Nadeem, A; Ponnoth, DS; Tilley, S | 1 |
| Chanyshev, B; Hochhauser, E; Isak, A; Leshem-Lev, D; Shainberg, A | 1 |
| Antonioli, L; Awwad, O; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M | 1 |
| Bender, K; Kienitz, MC; Littwitz, C; Pott, L; Timpert, M | 1 |
| Aust, G; Dacho, AK; Dietz, A; Lyutenski, S | 1 |
| Cock, HR; Hamil, NE; Walker, MC | 1 |
| Forconi, S; Gori, T; Liuni, A; Luca, MC; Münzel, T; Muxel, S; Parker, JD | 1 |
| Apodaca, G; Herrington, H; Jackson, EK; Prakasam, HS; Roppolo, JR | 1 |
| Chen, S; Dong, H; Hou, L; Hu, S; Wang, S; Xiong, L; Zhang, H; Zhang, J | 1 |
| Brown, KM; D'Agati, VD; Haase, VH; Kim, JY; Kim, M; Lee, HT; Park, SW | 1 |
| Feuer, R; Gottlieb, RA; Sayen, MR; Tabor-Godwin, JM; Tsueng, G | 1 |
| Harst, A; Hinze, AV; Mayer, P; von Kügelgen, I | 1 |
| Crawford, DC; Jiang, X; Mennerick, S; Taylor, A | 1 |
| Dekker, SJ; Ijzerman, AP; Langemeijer, EV; Verzijl, D | 1 |
| Dick, GM; Kunduri, SS; Mustafa, SJ; Nayeem, MA; Ponnoth, DS | 1 |
| Brown, KM; D'Agati, VD; Greene, RW; Ham, A; Kim, JY; Kim, M; Lee, HT | 1 |
| Dacho, AK; Dietz, A; Mueller, K | 1 |
| Clasadonte, J; Halassa, MM; Haydon, PG; McIver, SR; Schmitt, LI | 1 |
| Chaimovitz, C; Douvdevani, A; Naamani, O | 1 |
| Boeck, CR; Ciruela, F; Constantino, LC; Gomez-Soler, M; Ludka, FK; Matheus, FC; Pamplona, FA; Prediger, RD; Tasca, CI | 1 |
| Liu, S; Mikami, DJ; Needleman, BJ; Qu, M; Wang, GD; Wang, XY; Wood, JD; Xia, Y; Zou, F | 1 |
| Beck, S; Benzie, AL; Muellers, SN; Parkin, DW; Stockman, BJ | 1 |
| Amédée, T; Cunha, RA; George, J; Mulle, C | 1 |
| Caciagli, F; Ciccarelli, R; D'Alimonte, I; Di Iorio, P; Giuliani, P; Marchisio, M; Mastrangelo, F; Pierdomenico, L; Quaresima, R; Zuccarini, M | 1 |
| Blundon, JA; Eom, TY; Freeman, BB; Hackett, TA; Han, SB; Kerekes, RA; Pani, A; Rose, DC; Roy, NC; Sample, KJ; Smeyne, RJ; Teubner, BJW; Vuppala, PK; Yu, J; Zakharenko, SS | 1 |
| Adebiyi, A; Buddington, RK; Peixoto-Neves, D; Soni, H | 1 |
| Cooper, SL; Hill, SJ; Jörg, M; March, J; Sabbatini, AR; Scammells, PJ; Woolard, J | 1 |
| Buccioni, M; Coelho, JE; Dal Ben, D; Lambertucci, C; Lopes, LV; Marques-Morgado, I; Martí Navia, A; Marucci, G; Spinaci, A; Volpini, R | 1 |
| Langston, JL; Meads, KL; Myers, TM; Shih, TM; Thomas, TP | 1 |
| Acon-Chen, C; Loughery, TN; Shih, TM; Whitten, KA | 1 |
2 review(s) available for 2-chloro-n(6)cyclopentyladenosine and adenosine
| Article | Year |
|---|---|
Ischemic preconditioning--do we need more (pharmacological) experiments?
Topics: Adenosine; Animals; Blood Flow Velocity; Bradykinin; Coronary Vessels; Humans; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Norepinephrine; Purinergic P1 Receptor Agonists | 1997 |
Chronic pharmacological preconditioning against ischemia.
Topics: Adenosine; Animals; Cardiotonic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning, Myocardial; Mice; Morphine; Myocardial Infarction; Nitric Oxide Synthase Type II; Nitroglycerin; Rats; Swine | 2011 |
209 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and adenosine
| Article | Year |
|---|---|
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.
Topics: 2-Chloroadenosine; Animals; Brain; In Vitro Techniques; Rats; Receptors, Purinergic; Structure-Activity Relationship | 1991 |
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Purine Nucleosides; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Sulfur Radioisotopes | 2000 |
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
Topics: Adenosine A1 Receptor Agonists; Adenosine Monophosphate; Administration, Oral; Analgesics; Animals; Behavior, Animal; HEK293 Cells; Humans; Male; Mice; Nociception; Receptor, Adenosine A1; Substrate Specificity; Temperature | 2012 |
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Topics: Adenosine; Bridged Bicyclo Compounds, Heterocyclic; Cyclopentanes; Dose-Response Relationship, Drug; Drug Discovery; Humans; Molecular Structure; Purinergic P1 Receptor Agonists; Receptor, Adenosine A1; Receptor, Adenosine A3; Structure-Activity Relationship; Substrate Specificity | 2016 |
Ischemic preconditioning protects against infarction in rat heart.
Topics: Adaptation, Physiological; Adenosine; Animals; Coronary Disease; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Infarction; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Ventricular Fibrillation | 1992 |
Reduction of postischemic leukocyte-endothelium interaction by adenosine via A2 receptor.
Topics: Adenosine; Animals; Cell Adhesion; Cricetinae; Endothelium, Vascular; Ischemia; Leukocytes; Mesocricetus; Muscles; Phenethylamines; Receptors, Purinergic; Reperfusion Injury; Thioinosine; Xanthines | 1992 |
Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.
Topics: Adenosine; Animals; Coronary Disease; Female; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Infarction; Phenethylamines; Phenylisopropyladenosine; Rabbits | 1992 |
Myocardial preconditioning. Part of the adenosine revival.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Heart; Humans; Myocardium; Receptors, Purinergic | 1992 |
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carrier Proteins; Cyclic AMP; Cyclic AMP Receptor Protein; Female; Guinea Pigs; Heart Atria; Isoproterenol; Male; Myocardium; Pertussis Toxin; Virulence Factors, Bordetella | 1990 |
2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors.
Topics: Adenosine; Animals; Brain; Catalysis; In Vitro Techniques; Isotope Labeling; Kinetics; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Rats; Receptors, Purinergic | 1989 |
2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.
Topics: Adenosine; Adenylyl Cyclases; Adipose Tissue; Animals; Blood Platelets; Brain; Corpus Striatum; Humans; In Vitro Techniques; Rats; Receptors, Purinergic | 1988 |
Preconditioning of isolated rabbit cardiomyocytes: induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor.
Topics: Adenosine; Animals; Cell Size; Cell Survival; Cells, Cultured; Glucose; Heart; Myocardial Ischemia; Myocardium; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rabbits; Theophylline; Time Factors | 1994 |
The A1 agonist CCPA reduced bisoxonol-monitored membrane potential depolarization elicited by high K+ in cerebrocortical nerve endings.
Topics: Adenosine; Animals; Cerebral Cortex; Fluorescent Dyes; Male; Membrane Potentials; Nerve Endings; Phenethylamines; Potassium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Synaptosomes; Thiobarbiturates; Triazoles; Veratridine; Xanthines | 1995 |
Biochemical and pharmacological evidence for the presence of A1 but not A2a adenosine receptors in the brain of the low vertebrate teleost Carassius auratus (goldfish).
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Goldfish; Hydrogen-Ion Concentration; Mammals; Neurotransmitter Agents; Phenethylamines; Radioligand Assay; Receptors, Purinergic P1; Species Specificity; Temperature | 1995 |
Identification of domains of the human A1 adenosine receptor that are important for binding receptor subtype-selective ligands using chimeric A1/A2a adenosine receptors.
Topics: Adenosine; Analysis of Variance; Animals; Base Sequence; Binding Sites; Binding, Competitive; Cell Line; Chlorocebus aethiops; Humans; Kinetics; Ligands; Molecular Sequence Data; Oligodeoxyribonucleotides; Phenethylamines; Protein Structure, Secondary; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Recombinant Fusion Proteins; Sequence Deletion; Transfection; Tritium; Xanthines | 1995 |
Acting via A2 receptors, adenosine inhibits the production of tumor necrosis factor-alpha of endotoxin-stimulated human polymorphonuclear leukocytes.
Topics: Adenosine; Endotoxins; Humans; Kinetics; Neutrophils; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 1995 |
Modeling hemodynamic profiles by telemetry in the rat. A study with A1 and A2a adenosine agonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Animals; Hemodynamics; Male; Models, Biological; Platelet Aggregation Inhibitors; Rats; Rats, Inbred SHR; Telemetry | 1995 |
Isolation and characterization of an avian A1 adenosine receptor gene and a related cDNA clone.
Topics: Adenosine; Amino Acid Sequence; Animals; Base Sequence; Brain Chemistry; Chickens; Cloning, Molecular; Cyclic AMP; DNA Probes; DNA, Complementary; Dogs; Gene Amplification; Gene Expression; Genome; Introns; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Transcription, Genetic; Transfection | 1995 |
Adenosine attenuates phorbol ester-induced negative inotropic and vasoconstrictive effects in rat hearts.
Topics: Adenosine; Animals; Coronary Circulation; Diglycerides; Heart; In Vitro Techniques; Indoles; Male; Maleimides; Myocardial Contraction; Perfusion; Phenethylamines; Pressure; Rats; Rats, Wistar; Receptors, Purinergic P1; Tetradecanoylphorbol Acetate; Vasoconstriction | 1994 |
Adenosine A1-receptor mechanisms antagonize beta-adrenergic pulmonary vasodilation in hypoxia.
Topics: Adenosine; Animals; Colforsin; Isoproterenol; Oxygen; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Vasodilation | 1994 |
Adenosine suppresses excitatory glutamatergic inputs to rat hypoglossal motoneurons in vitro.
Topics: 2-Chloroadenosine; Action Potentials; Adenosine; Animals; Female; Hypoglossal Nerve; Kynurenic Acid; Male; Membrane Potentials; Motor Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Purinergic P1; Xanthines | 1994 |
Characterization of the adenosine receptor in microvascular coronary endothelial cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Antihypertensive Agents; Cells, Cultured; Colforsin; Coronary Vessels; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Isoproterenol; Myocardium; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Thioinosine; Vasodilator Agents | 1994 |
Adenosine A1 and A2 receptor agonists alter cardiac functions and prostacyclin release in the isolated guinea-pig heart.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Animals; Antihypertensive Agents; Cardiac Pacing, Artificial; Cells, Cultured; Coronary Circulation; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Guinea Pigs; Heart; Heart Rate; Male; Myocardium; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Triazoles; Vasodilation; Ventricular Function, Left; Xanthines | 1994 |
Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
Topics: Adenosine; Anesthesia; Animals; Behavior, Animal; Cattle; Coronary Circulation; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Mice; Myocardial Contraction; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Xanthines | 1994 |
Electrophysiological subtypes of inhibitory P1 purinoceptors on myenteric neurones of guinea-pig small bowel.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Membrane Potentials; Myenteric Plexus; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1 | 1994 |
Effects of selective adenosine A1 and A2 receptor agonists and antagonists on local rates of energy metabolism in the rat brain.
Topics: Adenosine; Animals; Blood Pressure; Brain; Cochlea; Deoxyglucose; Energy Metabolism; Glucose; Male; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Xanthines | 1994 |
P1-purinoceptor-mediated modulation of neural noradrenaline and ATP release in guinea-pig vas deferens.
Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Animals; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Purinergic P1; Receptors, Purinergic P2; Suramin; Vas Deferens; Yohimbine | 1994 |
2-Chloro-N6-cyclopentyladenosine (CCPA), an adenosine A1 receptor agonist, suppresses ethanol withdrawal syndrome in rats.
Topics: Adenosine; Alcohol Withdrawal Delirium; Animals; Dose-Response Relationship, Drug; Male; Neurologic Examination; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 1994 |
In vivo and ex vivo effects of adenosine A1 and A2 receptor agonists on platelet aggregation in the rabbit.
Topics: Adenosine; Adenosine Diphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rabbits | 1994 |
Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.
Topics: Adenosine; Animals; Heart; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Rabbits; Receptors, Purinergic P1; Theophylline; Time Factors | 1994 |
The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of ischaemic preconditioning in rabbit heart.
Topics: Acetylcholine; Adenosine; Animals; Bradycardia; Drug Tolerance; Female; Hemodynamics; Hypotension; Infusions, Intravenous; Male; Muscle Proteins; Myocardial Infarction; Myocardial Ischemia; Myocardium; Necrosis; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Muscarinic; Receptors, Purinergic P1 | 1994 |
Characterization of adenosine receptors in a model of cultured neurons from rat forebrain.
Topics: Adenosine; Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Antihypertensive Agents; Cell Membrane; Cells, Cultured; Embryo, Mammalian; Female; Guanylyl Imidodiphosphate; Kinetics; Neurons; Phenethylamines; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Tritium | 1994 |
Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8 substituted pyrazolo-triazolo-pyrimidine, on in vitro functional models.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cattle; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phosphoric Diester Hydrolases; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinazolines; Rabbits; Rats; Rats, Sprague-Dawley; Triazoles; Vasodilator Agents; Xanthines | 1994 |
Effects of PACAP on morphologically identified myenteric neurons in guinea pig small bowel.
Topics: Action Potentials; Adenosine; Animals; Colforsin; Guinea Pigs; Intestine, Small; Male; Myenteric Plexus; Neuroglia; Neurons; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Cell Surface; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone | 1993 |
Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Drug Tolerance; Hemodynamics; Male; Phenethylamines; Rats; Rats, Inbred SHR; Receptors, Purinergic P1 | 1994 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Depression, Chemical; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Antagonists; Receptors, GABA; Receptors, Purinergic P1; Seizures; Sulfur Radioisotopes; Synaptic Transmission; Tritium; Xanthines | 1993 |
Adenosine and A1 selective agonists offer minimal protection against ischaemic injury to isolated rat cardiomyocytes.
Topics: Adenosine; Animals; Carbachol; Cell Death; Cells, Cultured; Iodoacetates; Iodoacetic Acid; Isoproterenol; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Sprague-Dawley; Theophylline | 1993 |
Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein.
Topics: Acetylcholine; Adenosine; Animals; Arrhythmias, Cardiac; GTP-Binding Proteins; Heart Rate; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 1993 |
Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbits.
Topics: Adenosine; Animals; Disease Models, Animal; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rabbits; Receptors, Purinergic | 1993 |
Effects of selective A1 and A2 adenosine receptor agonists on cardiovascular tissues.
Topics: Adenosine; Animals; Aorta; Cardiovascular System; Cattle; Coronary Vessels; Depression, Chemical; Heart Rate; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Purinergic; Vasodilation | 1993 |
Identification and characterization of adenosine A1 receptor-cAMP system in human glomeruli.
Topics: Adenosine; Binding, Competitive; Cyclic AMP; Humans; In Vitro Techniques; Kidney Glomerulus; Kinetics; Radioligand Assay; Receptors, Purinergic; Xanthines | 1993 |
Adenosine prevents PMA-induced lung injury via an A2 receptor mechanism.
Topics: Adenosine; Animals; Blood Pressure; Capillary Permeability; Cyclic AMP; Dogs; Endothelium; Female; In Vitro Techniques; Isoproterenol; Lung Diseases; Male; Neutrophils; Pulmonary Circulation; Purinergic Antagonists; Receptors, Purinergic; Tetradecanoylphorbol Acetate; Vascular Resistance; Xanthines | 1993 |
Affinity of central adenosine A1 receptors is decreased in spontaneously hypertensive rats.
Topics: Adenosine; Animals; Binding, Competitive; Brain; Female; GTP-Binding Proteins; Guanosine Triphosphate; Hypertension; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Purinergic; Xanthines | 1993 |
Expression of adenosine A1 receptors in cultured neurons from fetal rat brain.
Topics: Adenosine; Animals; Brain; Cells, Cultured; Fetus; Neurons; Rats; Receptors, Purinergic; Regression Analysis | 1993 |
1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Brain; Cell Line; Coronary Vessels; Female; Guinea Pigs; Heart; Male; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Vasodilation; Xanthines | 1995 |
Effects of pH on responses to adenosine, CGS 21680, carbachol and nitroprusside in the isolated perfused superior mesenteric arterial bed of the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antihypertensive Agents; Carbachol; Colforsin; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mesenteric Arteries; Methoxamine; Nitroprusside; Perfusion; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents; Xanthines | 1995 |
Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Glyburide; Isoquinolines; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Phenethylamines; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Sulfonamides; Thionucleotides | 1995 |
Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices.
Topics: Adenosine; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acids; Glutamic Acid; Glycine; Hippocampus; Male; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Xanthines | 1996 |
Effects of repeated administration of selective adenosine A1 and A2A receptor agonists on pentylenetetrazole-induced convulsions in the rat.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures | 1995 |
Concentration-response relationships for adenosine agonists during preconditioning of rabbit cardiomyocytes.
Topics: Adenosine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Heart; Ischemic Preconditioning, Myocardial; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1; Xanthines | 1996 |
Chronic ethanol intoxication enhances [3H]CCPA binding and does not reduce A1 adenosine receptor function in rat cerebellum.
Topics: Adenosine; Alcoholism; Animals; Cerebellar Cortex; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Isoniazid; Male; Membranes; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Seizures; Substance Withdrawal Syndrome; Tremor; Xanthines | 1996 |
Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum.
Topics: Adenosine; Animals; Antihypertensive Agents; Caffeine; Camptothecin; Dopamine; Enzyme Inhibitors; Extracellular Space; Irinotecan; Male; Microdialysis; Neostriatum; Phenethylamines; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theobromine; Vasodilator Agents | 1996 |
Effects of adenosine-receptor agonists on renin release in anaesthetized rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Hemodynamics; Infusions, Intravenous; Kidney; Nerve Fibers; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Renin | 1995 |
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.
Topics: Adenosine; Animals; Endotoxemia; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha | 1996 |
Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene.
Topics: Acoustic Stimulation; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Piperazines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Triazoles; Xanthines | 1996 |
Inhibitory and excitatory effects of adenosine antagonists on spontaneous locomotor activity in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Antineoplastic Agents; Male; Mice; Motor Activity; Purinergic P1 Receptor Agonists; Purines; Sulfonamides; Theophylline; Xanthines | 1997 |
Protection against global ischemia in the rabbit isolated heart 24 hours after transient adenosine A1 receptor activation.
Topics: Adenosine; Animals; Blood Pressure; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Theophylline | 1997 |
Hemodynamic changes do not mediate the cardioprotection induced by the A1, adenosine receptor agonist CCPA in the rabbit.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Animals; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Felodipine; Hemodynamics; Male; Myocardial Infarction; Purinergic P1 Receptor Agonists; Rabbits; Vasodilator Agents | 1997 |
Cardioprotective effects of adenosine A1 and A2A receptor agonists in the isolated rat heart.
Topics: Adenosine; Analysis of Variance; Animals; Antihypertensive Agents; Creatine Kinase; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury; Vasodilator Agents | 1997 |
Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum.
Topics: Adenosine; Animals; Antihypertensive Agents; Corpus Striatum; Enzyme Inhibitors; Isoquinolines; Phenethylamines; Presynaptic Terminals; Protein Kinase C; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sensitivity and Specificity; Sulfonamides; Synaptosomes; Triazines; Triazoles; Tritium; Xanthines | 1997 |
Time course of delayed myocardial protection after transient adenosine A1-receptor activation in the rabbit.
Topics: Adenosine; Animals; Blood Pressure; Heart Rate; HSP70 Heat-Shock Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Purinergic P1 Receptor Agonists; Rabbits; Time Factors | 1997 |
Regulation of muscarinic acetylcholine receptor-mediated synaptic responses by adenosine receptors in the rat hippocampus.
Topics: Adenosine; Adenosine Kinase; Animals; Atropine; Cyclic AMP; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Hippocampus; Membrane Potentials; Parasympatholytics; Parasympathomimetics; Physostigmine; Quinoxalines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Purinergic P1; Synaptic Membranes; Synaptic Transmission; Xanthines | 1997 |
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines | 1997 |
Binding of an adenosine A1 receptor agonist and adenosine A1 receptor antagonist to sheep pineal membranes.
Topics: Adenosine; Animals; Binding, Competitive; Female; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Ligands; Male; Membranes; Pineal Gland; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Sheep; Xanthines | 1997 |
Non-selective effects of adenosine A1 receptor ligands on energy metabolism and macromolecular biosynthesis in cultured central neurons.
Topics: Adenosine; Adenylyl Cyclases; Animals; Biological Transport; Cell Survival; Cells, Cultured; Cyclic AMP; Deoxyglucose; Embryo, Mammalian; Energy Metabolism; Female; Kinetics; Leucine; Ligands; Neurons; Prosencephalon; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; RNA; Theophylline; Uridine | 1998 |
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines | 1998 |
CNS adenosine A1 receptors are altered after the administration of convulsant 3-mercaptopropionic acid and cyclopentyladenosine: an autoradiographic study.
Topics: 3-Mercaptopropionic Acid; Adenosine; Animals; Anticonvulsants; Autoradiography; Brain; Convulsants; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Receptors, Purinergic P1 | 1998 |
Myocardial adenosine A1-receptor sensitivity during juvenile and adult stages of maturation.
Topics: Adenosine; Adenylyl Cyclases; Adrenergic beta-Agonists; Aging; Animals; Heart; Heart Rate; Isoproterenol; Male; Myocardial Contraction; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Vasodilator Agents; Xanthines | 1998 |
Effects of adenosine receptor agonists on renal function in anaesthetized rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Denervation; Glomerular Filtration Rate; Hypertension, Renal; Kidney; Male; Purinergic P1 Receptor Agonists; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Purinergic P1; Receptors, Purinergic P2; Sodium; Urodynamics | 1997 |
ATP and glutamate are released from separate neurones in the rat medial habenula nucleus: frequency dependence and adenosine-mediated inhibition of release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Adenosine Triphosphate; Aniline Compounds; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Habenula; Male; Neurons; Nucleotidases; Presynaptic Terminals; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Glutamate; Receptors, Purinergic P1; Suramin; Synaptic Transmission; Synaptic Vesicles; Theophylline | 1998 |
Adenosine modulates cell proliferation in human colonic adenocarcinoma. I. Possible involvement of adenosine A1 receptor subtypes in HT29 cells.
Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Binding, Competitive; Cell Division; Cyclic AMP; HT29 Cells; Humans; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1 | 1998 |
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis | 1998 |
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler Flowmetry; Male; Parietal Lobe; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilation | 1998 |
Adenosine A1 receptors modulate anxiety in CD1 mice.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Brain; Light; Male; Maze Learning; Mice; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1 | 1998 |
Adenosine A1 receptor stimulation antagonizes the negative inotropic effects of the PKC activator dioctanoylglycerol.
Topics: Adenosine; Analysis of Variance; Animals; Depression, Chemical; Diglycerides; Enzyme Activation; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Xanthines | 1998 |
A2A-adenosine receptor reserve for coronary vasodilation.
Topics: Adenosine; Animals; Coronary Circulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazines; Triazoles; Vasodilation | 1998 |
Modulation of ischemia-evoked release of excitatory and inhibitory amino acids by adenosine A1 receptor agonist.
Topics: Adenosine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Inbred SHR; Regional Blood Flow; Taurine | 1998 |
Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Gas Analysis; Hydrogen-Ion Concentration; Hypoxia; Male; Muscle, Skeletal; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Respiration; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 1999 |
Cellular mechanisms by which adenosine induces vasodilatation in rat skeletal muscle: significance for systemic hypoxia.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Enzyme Inhibitors; Femoral Artery; Glyburide; Heart Rate; Hypoglycemic Agents; Hypoxia; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Vasodilator Agents | 1999 |
Adenosine and ADP prevent apoptosis in cultured rat cerebellar granule cells.
Topics: Adenosine; Adenosine Diphosphate; Animals; Apoptosis; Cells, Cultured; Cerebellum; In Situ Nick-End Labeling; Neurons; Potassium Chloride; Rats; Rats, Wistar; Receptors, Purinergic; Xanthines | 1998 |
Adenosine A2a receptors increase arterial endothelial cell nitric oxide.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carotid Arteries; Cells, Cultured; Endothelium, Vascular; Humans; Iliac Artery; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Swine; Triazines; Triazoles; Xanthines | 1998 |
Pharmacological interactions between magnesium ion and adenosine on monoaminergic system in the central nervous system.
Topics: Adenosine; Animals; Biogenic Monoamines; Caffeine; Carbamazepine; Central Nervous System; Central Nervous System Stimulants; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Magnesium; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Theobromine; Theophylline; Visual Cortex | 1998 |
Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin.
Topics: Adenosine; Animals; Antihypertensive Agents; Biological Transport; Caffeine; Central Nervous System Stimulants; Fluoxetine; Hippocampus; Male; Microdialysis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quipazine; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Theobromine; Theophylline; Vasodilator Agents | 1999 |
Pyrazolopyridine derivatives act as competitive antagonists of brain adenosine A1 receptors: [35S]GTPgammaS binding studies.
Topics: Adenosine; Animals; Binding, Competitive; Cerebral Cortex; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Protein Binding; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 1999 |
Inhibition by adenosine receptor agonists of synaptic transmission in rat periaqueductal grey neurons.
Topics: Action Potentials; Adenosine; Animals; Colforsin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1999 |
Effects of adenosinergic agents on the vascular resistance and on the optic nerve response in the perfused cat eye.
Topics: Adenosine; Animals; Cats; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Electrophysiology; Female; Optic Nerve; Perfusion; Phenethylamines; Photic Stimulation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Retina; Theobromine; Theophylline; Vascular Resistance | 1999 |
Delayed preconditioning with adenosine is mediated by opening of ATP-sensitive K(+) channels in rabbit heart.
Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Animals; Cardiovascular Agents; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Potassium Channels; Rabbits; Time Factors | 1999 |
Mechanisms of inhibitory effects of zinc and cadmium ions on agonist binding to adenosine A1 receptors in rat brain.
Topics: Adenosine; Amino Acids, Sulfur; Animals; Binding, Competitive; Brain; Cadmium; Culture Media; Diethyl Pyrocarbonate; Dithionitrobenzoic Acid; Dithiothreitol; Histidine; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Sulfhydryl Compounds; Sulfhydryl Reagents; Tritium; Zinc | 1999 |
Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes.
Topics: Adenosine; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Cyclopropanes; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glycine; Kinetics; Nerve Growth Factors; Neuroglia; Proline; Rats; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Transcription, Genetic | 1999 |
Effect of A1 adenosine receptor agonist upon cochlear dysfunction induced by transient ischemia.
Topics: Action Potentials; Adenosine; Animals; Cochlea; Differential Threshold; Guinea Pigs; Ischemia; Purinergic P1 Receptor Agonists | 1999 |
Increase in the vasorelaxant potency of K(ATP) channel opening drugs by adenosine A(1) and A(2) receptors in the pig coronary artery.
Topics: Adenosine; Animals; ATP-Binding Cassette Transporters; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; KATP Channels; Nicorandil; Phenethylamines; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Swine; Triazines; Triazoles; Vasodilator Agents; Xanthines | 1999 |
Ischemic preconditioning and glucose metabolism during low-flow ischemia: role of the adenosine A1 receptor.
Topics: Adenosine; Animals; Glucose; Glycolysis; Ischemic Preconditioning, Myocardial; Male; Myocardial Ischemia; Myocardium; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Regional Blood Flow; Theophylline | 1999 |
In vivo effects of adenosine A1 receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo 13C NMR spectroscopy.
Topics: Acetates; Adenosine; Amino Acids; Animals; Astrocytes; Behavior, Animal; Carbon Isotopes; Cerebral Cortex; Glucose; Magnetic Resonance Spectroscopy; Male; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Tissue Extracts; Xanthines | 2000 |
Adenosine receptor expression and modulation of Ca(2+) channels in rat striatal cholinergic interneurons.
Topics: Adenosine; Animals; Calcium Channels, N-Type; Choline O-Acetyltransferase; Corpus Striatum; Ethylmaleimide; GTP-Binding Proteins; Guanosine Diphosphate; In Vitro Techniques; Interneurons; Membrane Potentials; Patch-Clamp Techniques; Phenethylamines; Rats; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theophylline; Thionucleotides | 2000 |
Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adrenergic beta-Agonists; Animals; Calcium; Cantharidin; Cyclic AMP; Enzyme Inhibitors; Intracellular Membranes; Isoproterenol; Male; Myocardial Contraction; Myocardium; Phosphoric Monoester Hydrolases; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1 | 2000 |
Activated cardiac adenosine A(1) receptors translocate out of caveolae.
Topics: Adenosine; Animals; Biomarkers; Caveolin 3; Caveolins; Cell Membrane; Cells, Cultured; Cholesterol; Male; Membrane Proteins; Microscopy, Immunoelectron; Myocardium; Nitric Oxide Synthase; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Xanthines | 2000 |
Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells.
Topics: Adenosine; Animals; beta-N-Acetylhexosaminidases; Blood Pressure; Gene Targeting; Heart Rate; Inflammation; Lipopolysaccharides; Mast Cells; Mice; Mice, Knockout; Protein Binding; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Tumor Necrosis Factor-alpha; Xanthines | 2000 |
Effects of adenosine receptor agonists on efferent renal nerve activity in anesthetized rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Baroreflex; Blood Pressure; Denervation; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Kidney; Male; Neurons, Efferent; Nitroprusside; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Regression Analysis; Sympathetic Nervous System; Time Factors; Vagotomy | 2000 |
Anticonvulsant A(1) receptor-mediated adenosine action on neuronal networks in the brainstem-spinal cord of newborn rats.
Topics: Adenosine; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Anticonvulsants; Bicuculline; Brain Stem; Chloride Channels; GABA Antagonists; Medulla Oblongata; Membrane Potentials; Nerve Net; Neural Inhibition; Neural Pathways; Neurons; Rats; Receptors, Purinergic P1; Respiration; Spinal Cord; Xanthines | 2000 |
Histamine H(2) receptor activated chloride conductance in myenteric neurons from guinea pig small intestine.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Animals; Calcium Channel Blockers; Chlorides; Cyclic AMP; Cyclooxygenase Inhibitors; Electric Conductivity; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guinea Pigs; Histamine; Intestine, Small; Membrane Potentials; Myenteric Plexus; Neurons; Niflumic Acid; omega-Conotoxins; Paracrine Communication; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Agonists; Receptors, Histamine H2; Stress, Psychological; Theophylline; Thionucleotides | 2000 |
Transient depression of excitatory synaptic transmission induced by adenosine uptake inhibition in rat hippocampal slices.
Topics: Adenosine; Aminophylline; Analgesics; Animals; Bicuculline; Dipyridamole; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; GABA Antagonists; Glyburide; Hippocampus; Hypoglycemic Agents; Male; Naphthalenes; Neomycin; Neurons; Neurotransmitter Agents; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P1; Synaptic Transmission; Xanthines | 2000 |
Adenosine A(1) receptor activation induces delayed preconditioning in rats mediated by manganese superoxide dismutase.
Topics: Adenosine; Animals; Arteries; Coronary Circulation; Coronary Vessels; Hemodynamics; Ischemic Preconditioning, Myocardial; Ligation; Male; Myocardial Infarction; Myocardium; Oligonucleotides, Antisense; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Risk Factors; Superoxide Dismutase; Time Factors | 2000 |
Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers.
Topics: Adenosine; Allopurinol; Animals; Cyclic AMP; Endothelium, Vascular; Glutathione; Insulin; Ischemia; Ischemic Preconditioning; Liver; Male; Organ Preservation Solutions; Purinergic P1 Receptor Agonists; Raffinose; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Reperfusion Injury | 2000 |
Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.
Topics: Adenosine; Animals; Enzyme Inhibitors; Female; Heart; Ischemic Preconditioning, Myocardial; Isothiuronium; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Ventricular Function, Left | 2000 |
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats.
Topics: Acute Disease; Adenosine; Amylases; Animals; Ceruletide; Edema; Leukocytes; Male; Pancreas; Pancreatic Diseases; Pancreatitis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Taurocholic Acid | 2000 |
Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.
Topics: Adenosine; Aniline Compounds; Animals; Calcium; Decanoic Acids; Drug Synergism; Fluoresceins; Fluorescent Dyes; Glyburide; Heart Ventricles; Hydroxy Acids; Ion Transport; Male; Microscopy, Fluorescence; Myocardial Contraction; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Oxidation-Reduction; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Purinergic P1; Xanthenes; Xanthines | 2001 |
The calcium-dependent [3H]acetylcholine release from synaptosomes of brown trout (Salmo trutta) optic tectum is inhibited by adenosine A1 receptors: effects of enucleation on A1 receptor density and cholinergic markers.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine; Afferent Pathways; Animals; Calcium; Calcium Channel Blockers; Choline O-Acetyltransferase; Kinetics; Membrane Potentials; Nifedipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Potassium Chloride; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Superior Colliculi; Synaptosomes; Theophylline; Tritium; Trout | 2001 |
Antiarrhythmic effects of adenosine on ischemia-induced ventricular fibrillation.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Dipyridamole; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Theophylline; Ventricular Fibrillation | 2001 |
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.
Topics: Adenosine; Analysis of Variance; Animals; Brimonidine Tartrate; Electric Stimulation; Enzyme Inhibitors; Male; Myocardial Stunning; Myocardium; Norepinephrine; Perfusion; Phenethylamines; Phenylisopropyladenosine; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Sympathetic Nervous System; Theophylline; Time Factors; Xanthines | 2001 |
Role of adenosine and glycogen in ischemic preconditioning of rat hearts.
Topics: Adenosine; Adenosine Triphosphate; Animals; Glycogen; Hydrogen-Ion Concentration; Ischemic Preconditioning, Myocardial; Male; Myocardium; Phosphates; Phosphocreatine; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theophylline | 2001 |
Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons.
Topics: Action Potentials; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cadmium; Colforsin; Neurons, Afferent; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Receptors, Purinergic P1; Time Factors; Vagus Nerve; Xanthines | 2001 |
Antiadrenergic effects of adenosine in pressure overload hypertrophy.
Topics: Adenosine; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; Caffeine; Calcium; Cardiomegaly; Cells, Cultured; Coronary Circulation; Disease Models, Animal; Echocardiography; In Vitro Techniques; Inosine; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Perfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley | 2001 |
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.
Topics: Adenine; Adenosine; Animals; Binding, Competitive; Cell Line; Consciousness; Decanoic Acids; Humans; Hydroxy Acids; Iodine Radioisotopes; Ischemic Preconditioning, Myocardial; Membranes; Myocardial Infarction; Nitroarginine; Norbornanes; Phenethylamines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1 | 2001 |
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.
Topics: Adenosine; Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; L-Lactate Dehydrogenase; Microscopy, Electron; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines | 2001 |
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Electroencephalography; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Indicators and Reagents; Male; Neurotransmitter Agents; Pilocarpine; Rats; Rats, Wistar; Seizures; Xanthines | 2001 |
Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.
Topics: Adenosine; Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Calcium; Cells, Cultured; Doxorubicin; Electron Transport Complex IV; Heart; L-Lactate Dehydrogenase; Lipid Peroxidation; Mitochondria; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1 | 2001 |
Delayed or second window preconditioning induced by adenosine A1 receptor activation is independent of early generation of nitric oxide or late induction of inducible nitric oxide synthase.
Topics: Adenosine; Animals; Enzyme Induction; Enzyme Inhibitors; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rabbits; Receptors, Purinergic P1 | 2001 |
Seizure activity produces differential changes in adenosine A1 receptors within rat hippocampus.
Topics: Adenosine; Animals; Autoradiography; Hippocampus; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Purinergic P1; Seizures; Tritium | 2001 |
Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.
Topics: Acetamides; Adenosine; Analysis of Variance; Animals; Cryoprotective Agents; Dihydropyridines; Histamine H1 Antagonists; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Wistar; Receptors, Purinergic; Receptors, Purinergic P1; Theophylline; Time Factors | 2001 |
Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.
Topics: Adenosine; Aging; Animals; Diazoxide; Diglycerides; Heart; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Time Factors; Vasodilator Agents | 2001 |
Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.
Topics: Adenosine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzamides; Calcium; Cell Hypoxia; Cell Line; Cell Survival; Cells, Cultured; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Activation; Heart Ventricles; Humans; Hydroxy Acids; Ischemic Preconditioning, Myocardial; KATP Channels; Luminescent Proteins; Membrane Potentials; Mitochondria; Myocardium; Oxygen; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Recombinant Fusion Proteins; Sarcolemma; Time Factors; Ventricular Function; Xanthines | 2001 |
Mechanisms of glutamate release in the rat spinal cord slices during metabolic inhibition.
Topics: Adenosine; Animals; Arachidonic Acids; Baclofen; Calcium; Energy Metabolism; Enzyme Inhibitors; GABA Agonists; Glutamic Acid; In Vitro Techniques; Indazoles; Iodoacetates; Male; Neurotoxins; Phospholipases; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.
Topics: Adenosine; Analysis of Variance; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Glutamic Acid; In Vitro Techniques; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Synaptosomes; Triazoles; Xanthines | 2002 |
2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor.
Topics: Adenosine; Animals; CHO Cells; Cricetinae; Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3 | 2002 |
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blotting, Western; Cells, Cultured; Drosophila Proteins; Endothelial Growth Factors; Female; Interferon-gamma; Lipopolysaccharides; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenethylamines; Protein Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Theobromine; Toll-Like Receptor 4; Toll-Like Receptors; Triazines; Triazoles; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthines | 2002 |
Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.
Topics: Acetophenones; Adenosine; Animals; Benzopyrans; Creatine Kinase; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Isoenzymes; Male; Mice; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Protein Kinase C-delta; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Signal Transduction; Ventricular Function, Left | 2002 |
Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain.
Topics: Acute Disease; Adenosine; Animals; Behavior, Animal; Ligands; Mice; Nociceptors; Pain; Pain Measurement; Pyrimidines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles | 2002 |
Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?
Topics: Adenosine; Analysis of Variance; Animals; Atractyloside; Calcineurin Inhibitors; Cyclosporine; Decanoic Acids; Diazoxide; Enzyme Inhibitors; Hydroxy Acids; Ion Channels; Ischemic Preconditioning, Myocardial; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Permeability; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Purinergic P1 Receptor Agonists; Random Allocation; Rats; Rats, Sprague-Dawley; Tacrolimus | 2002 |
Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.
Topics: Adenosine; Animals; Cells, Cultured; Chloride Channels; Dose-Response Relationship, Drug; Enzyme Activators; Glycolates; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardium; Perfusion; Protein Kinase C; Rabbits; Receptors, Purinergic P1; Tetradecanoylphorbol Acetate | 2002 |
Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.
Topics: Adenosine; Animals; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Purinergic P1 Receptor Agonists; Rats; Rats, Mutant Strains; Receptor, Adenosine A2A | 2002 |
Reperfusion duration paradox with late myocardial preconditioning in rabbits.
Topics: Adenosine; Animals; Hemodynamics; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Nitric Oxide Donors; Purinergic P1 Receptor Agonists; Rabbits; S-Nitroso-N-Acetylpenicillamine; Time Factors | 2002 |
Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells.
Topics: Adenosine; Binding, Competitive; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Glycolipids; Gram-Negative Bacteria; Humans; Interleukin-6; Lipid A; Lipopolysaccharides; Phenethylamines; Pulmonary Artery; Purinergic P1 Receptor Antagonists; Radioligand Assay; Receptors, Purinergic P1; Thromboxane A2; Xanthines | 2002 |
Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology.
Topics: 2-Chloroadenosine; Adenosine; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Hand Strength; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Neuroprotective Agents; Postural Balance; Psychomotor Performance; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Xanthines | 2002 |
Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.
Topics: Adenosine; Analgesics, Opioid; Animals; ATP-Binding Cassette Transporters; Benzylidene Compounds; Free Radicals; Heart Diseases; In Vitro Techniques; KATP Channels; Mitochondria, Heart; Morphine; Myocardial Infarction; Myocardial Reperfusion Injury; Naltrexone; Potassium Channels; Potassium Channels, Inwardly Rectifying; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor Cross-Talk; Receptors, Opioid, delta; Receptors, Purinergic P1 | 2003 |
Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation.
Topics: Adenosine; Adenylyl Cyclases; Adrenergic beta-Agonists; Alkaline Phosphatase; Animals; Cyclic AMP-Dependent Protein Kinases; Heart Ventricles; Isoproterenol; Membrane Proteins; Myocardium; Phosphorylation; Precipitin Tests; Purinergic P1 Receptor Agonists; Rats; Receptors, Adrenergic, beta-1; Receptors, Purinergic P1 | 2003 |
A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus.
Topics: Adenosine; Animals; Cell Nucleus; CHO Cells; Cricetinae; Cricetulus; Female; Gene Expression Regulation; Genes, fos; Humans; Isoenzymes; Luciferases; MAP Kinase Signaling System; Protein Kinase C; Proto-Oncogene Proteins c-fos; Receptor, Adenosine A1; Transcription, Genetic | 2003 |
Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Injections; Kainic Acid; Male; Mice; Mice, Inbred Strains; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Temporal Lobe | 2003 |
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine; Chromatography, High Pressure Liquid; Dopamine; Injections, Subcutaneous; Male; Microdialysis; Morphine; Pyrimidines; Rats; Rats, Wistar; Receptors, Dopamine; Substance Withdrawal Syndrome; Triazoles | 2003 |
Comparison of effects of MgCl2 and Gpp(NH)p on antagonist and agonist radioligand binding to adenosine A1 receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Cell Membrane; Cerebral Cortex; Guanylyl Imidodiphosphate; Magnesium Chloride; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Xanthines | 2003 |
A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.
Topics: Acute Kidney Injury; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Apoptosis; Biomarkers; Genotype; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Interleukin-1; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neutrophils; Receptor, Adenosine A1; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha; Xanthines | 2004 |
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.
Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; HSP70 Heat-Shock Proteins; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate | 2004 |
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.
Topics: 2,4-Dinitrophenol; Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Cardiotonic Agents; Cells, Cultured; Cyclosporine; Diazoxide; Electric Conductivity; Ion Channel Gating; Ion Channels; Ion Transport; Ischemic Preconditioning, Myocardial; Lactones; Macromolecular Substances; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Spiro Compounds; Uncoupling Agents; Vasodilator Agents | 2004 |
Comparative analysis of putative agonist-binding modes in the human A1 adenosine receptor.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Binding Sites; Humans; Mathematics; Models, Molecular; Receptor, Adenosine A1; Thermodynamics | 2004 |
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Male; Maze Learning; Mice; Receptor, Adenosine A1; Triazines; Triazoles; Xanthines | 2004 |
Role of A1 adenosine receptors in regulation of vascular tone.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Female; In Vitro Techniques; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Receptor, Adenosine A1; Type C Phospholipases; Vasodilation; Vasodilator Agents; Xanthines | 2005 |
Modulating effect of adenosine deaminase on function of adenosine A1 receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Calcium; Cell Line; Cell Membrane; Embryo, Mammalian; Humans; Kidney; Radioligand Assay; Receptor, Adenosine A1; Signal Transduction; Xanthines | 2005 |
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.
Topics: Adenosine; Animals; Behavior, Animal; Brain; Caffeine; Dose-Response Relationship, Drug; Drug Administration Schedule; Injections, Intraperitoneal; Male; Memory, Short-Term; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A2A; Social Behavior; Triazines; Triazoles; Xanthines | 2005 |
Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Heart Ventricles; Hydrogen Peroxide; Ischemic Preconditioning, Myocardial; Male; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocytes, Cardiac; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Time Factors | 2005 |
New adenosine A2A receptor antagonists: actions on Parkinson's disease models.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Behavior, Animal; Binding, Competitive; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Drug Synergism; Levodopa; Male; Molecular Structure; Parkinson Disease; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Tritium | 2005 |
Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Amidines; Animals; Benzylamines; Blood Pressure; Body Temperature; Enzyme Inhibitors; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Knockout; Myocardial Infarction; Myocardium; Nitric Oxide Donors; Receptors, Opioid, delta | 2005 |
Pretreatment with an adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial ischemic preconditioning.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiovascular Agents; Ischemic Preconditioning, Myocardial; Lidocaine; Male; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium Channels | 2005 |
Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.
Topics: Adenosine; Animals; Heart; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Ischemia; Phenethylamines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Xanthines | 2006 |
Indirect activation of adenosine A1 receptors in cultured rat hippocampal neurons by volatile anaesthetics.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Anesthetics, Inhalation; Animals; Calcium Signaling; Cells, Cultured; Deoxyadenosines; Dose-Response Relationship, Drug; Enflurane; Guanosine; Hippocampus; Magnesium; Methyl Ethers; Neurons; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Sevoflurane; Signal Transduction; Thionucleosides; Xanthines | 2005 |
Anesthetic preconditioning as the alternative to ischemic preconditioning.
Topics: Adenosine; Anesthetics, Inhalation; Arrhythmias, Cardiac; Humans; Ischemic Preconditioning, Myocardial; Lidocaine | 2006 |
Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine-5'-(N-ethylcarboxamide); Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Rats; Receptor, Adenosine A1; Xanthines | 2006 |
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Benzazepines; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Drug Interactions; Gene Expression; In Vitro Techniques; Mice; Mice, Inbred C57BL; Neostriatum; Phenethylamines; Raclopride; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Dopamine D1; Signal Transduction; Threonine; Triazines; Triazoles; Xanthines | 2006 |
Differential effect of serum from bipolar versus schizophrenic patients on spontaneous acetylcholine release at mammalian neuromuscular junction.
Topics: Acetylcholine; Adenosine; Adult; Analysis of Variance; Animals; Bipolar Disorder; Diaphragm; Evoked Potentials, Motor; Female; Humans; In Vitro Techniques; Male; Mice; Middle Aged; Neuromuscular Junction; Schizophrenia | 2006 |
Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Animal; Endotoxemia; Endotoxins; Energy Metabolism; Female; Lipopolysaccharides; Lung; Pulmonary Artery; Pulmonary Edema; Rabbits; Receptors, Purinergic P1; Respiratory Distress Syndrome; Time Factors; Uric Acid; Vasoconstriction | 2007 |
Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Glutathione; Ileum; Intestines; Male; Muscle Contraction; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Thiobarbituric Acid Reactive Substances; Xanthines | 2007 |
The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Analgesics; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Pain; Pain Threshold; Rats; Rats, Wistar | 2007 |
G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Calcium; Cells, Cultured; Cerebellum; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fluorometry; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Receptor Cross-Talk; Receptor, Adenosine A1; Receptors, Metabotropic Glutamate; Signal Transduction | 2007 |
Role of NO and COX pathways in mediation of adenosine A1 receptor-induced renal vasoconstriction.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blood Pressure; Enzyme Inhibitors; Kidney; Kidney Cortex; Kidney Medulla; Laser-Doppler Flowmetry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Receptor, Adenosine A1; Renal Circulation; Signal Transduction; Sodium, Dietary; Vasoconstriction | 2007 |
The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Analysis of Variance; Animals; Coronary Circulation; Heart; Hypertrophy; Ischemic Preconditioning, Myocardial; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A3; Reperfusion Injury | 2007 |
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.
Topics: Adenosine; Animals; Dihydropyridines; Disease Models, Animal; Hindlimb; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Phenethylamines; Phospholipase C beta; Pyrazoles; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Signal Transduction; Xanthines | 2007 |
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Biomarkers; Disease Models, Animal; HSP72 Heat-Shock Proteins; Immunohistochemistry; Ischemic Preconditioning; Liver; Liver Transplantation; Male; NF-kappa B; Nitric Oxide; Oxidants, Photochemical; Oxidative Stress; Ozone; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptor, Adenosine A1; Reperfusion Injury; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthines | 2008 |
Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Antioxidants; Caveolin 3; Cell Membrane; Cell Nucleus; Cytosol; Detergents; Enzyme Activation; Hydrogen Peroxide; In Vitro Techniques; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Octoxynol; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Adenosine A1; Subcellular Fractions; Tiopronin | 2008 |
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
Topics: Acetylcholine; Adenosine; Adenosine Kinase; Animals; Diabetes Mellitus, Type 2; Dipyridamole; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Male; Mice; Mice, Mutant Strains; Mice, Obese; Muscle Contraction; Muscle, Smooth; Nitroprusside; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Tubercidin; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21.
Topics: Adenosine; Animals; Carbachol; Chromosomes, Human, Pair 21; Electrocardiography; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Heart Rate; Humans; Methoxamine; Mice; Mice, Transgenic; Myocardium; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic | 2008 |
Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Antioxidants; Drug Evaluation, Preclinical; Female; Glutathione; Ischemic Preconditioning; Liver; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Receptor, Adenosine A1; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Xanthines | 2008 |
Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Cell Survival; Central Nervous System Depressants; Ethanol; Female; Hippocampus; Immunohistochemistry; Male; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Substance Withdrawal Syndrome; Tissue Culture Techniques; Xanthines | 2008 |
Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Androstanols; Animals; Diaphragm; Dipyridamole; Drug Synergism; Electric Stimulation; Male; Midazolam; Models, Animal; Neuromuscular Blocking Agents; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Rocuronium; Xanthines | 2008 |
Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Age Factors; Animals; Antibodies; Cells, Cultured; Coatomer Protein; Estrenes; Immunohistochemistry; Immunoprecipitation; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Protein Kinase C-epsilon; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Type C Phospholipases; Xanthines | 2009 |
Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiotonic Agents; Creatine Kinase, MB Form; Female; Glutathione; Heart; Heart Ventricles; Hyperhomocysteinemia; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Lactate Dehydrogenases; Male; Methionine; Myocardial Infarction; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Rats, Wistar; Severity of Illness Index; Thiobarbituric Acid Reactive Substances | 2009 |
[Metallothionein mediates cardioprotection induced by delayed preconditioning with adenosine A1 receptor agonist in rabbits].
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiotonic Agents; Ischemic Preconditioning, Myocardial; Male; Metallothionein; Myocardial Reperfusion Injury; Myocardium; Rabbits; Random Allocation; Superoxide Dismutase | 2009 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Intestinal Secretions; Male; Mecamylamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neural Inhibition; Neurogenic Bowel; Neurokinin-1 Receptor Antagonists; Nicotinic Antagonists; Piperidines; Propane; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Histamine H2; Receptors, Neurokinin-1; Reflex; Theophylline; Xanthines | 2009 |
The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Catheterization; Central Nervous System Agents; Dietary Fats; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Locomotion; Male; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptors, Opioid, mu; Xanthines | 2010 |
Adenosine A1 receptor blockage mediates theophylline-associated seizures.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Animals; Behavior, Animal; Body Temperature; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Enzyme Inhibitors; Hyperthermia, Induced; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Lew; Seizures; Theophylline; Tubercidin | 2010 |
Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Caveolin 3; Cell Membrane; Isoenzymes; Myocytes, Cardiac; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Xanthines | 2009 |
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.
Topics: Acoustic Stimulation; Adenosine; Adenosine A1 Receptor Agonists; Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Noise-Induced; Male; Oxidative Stress; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Tyrosine | 2010 |
Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Administration, Inhalation; Aerosols; Ambrosia; Animals; Antigens, Plant; Aorta; Asthma; Blotting, Western; Bronchial Hyperreactivity; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-5; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Plethysmography, Whole Body; Polymerase Chain Reaction; Receptor, Adenosine A1; RNA, Messenger; Vasodilation | 2010 |
Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Animals; Extracellular Signal-Regulated MAP Kinases; Heart; Hypoxia; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium Channels; Protective Agents; Rats | 2010 |
Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Benzenesulfonates; Colitis; Colon; Disease Models, Animal; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adenosine A2; Xanthines | 2011 |
Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Autocrine Communication; Carbachol; Cells, Cultured; Down-Regulation; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Heart Atria; Muscarinic Agonists; Myocytes, Cardiac; Patch-Clamp Techniques; Rats; Receptor Cross-Talk; Receptor, Adenosine A1; Receptor, Muscarinic M2; RNA Interference; Xanthines | 2011 |
Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats.
Topics: Adenosine; Animals; Catheterization, Central Venous; Infusions, Intravenous; Male; Necrosis; Rats; Rats, Wistar; Reperfusion Injury; Surgical Flaps; Vasodilator Agents | 2012 |
Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adrenergic beta-1 Receptor Agonists; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Intracellular Signaling Peptides and Proteins; Isoproterenol; Isoquinolines; Membrane Proteins; Myocardium; Myocytes, Cardiac; Organ Culture Techniques; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Protein Transport; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptors, Adrenergic, beta-1; Signal Transduction; Sulfonamides; Xanthines | 2012 |
Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.
Topics: Adenosine; Animals; Disease Models, Animal; Down-Regulation; Electric Stimulation; Electroencephalography; Hippocampus; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Status Epilepticus | 2012 |
Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.
Topics: Adenosine; Animals; Cyclophosphamide; Cystitis; Epithelium; Female; Models, Animal; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Urinary Bladder | 2012 |
Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.
Topics: Adenosine; Analysis of Variance; Animals; Brain Infarction; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Extremities; Glutathione; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Ischemic Preconditioning; Lipid Peroxidation; Male; Nervous System Diseases; Neuroprotective Agents; Nitrites; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Severity of Illness Index; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Xanthines | 2012 |
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
Topics: Acute Kidney Injury; Adenosine; Adenosine A1 Receptor Agonists; Animals; Kidney; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Statistical; Phosphotransferases (Alcohol Group Acceptor); Receptor, Adenosine A1; Receptors, Lysosphingolipid; Reperfusion Injury | 2012 |
The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.
Topics: Adenine; Adenosine; Animals; Autophagy; Cell Differentiation; Coxsackievirus Infections; Enterovirus B, Human; Fibroblast Growth Factors; Green Fluorescent Proteins; HeLa Cells; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sirolimus; Transduction, Genetic; Viral Load; Viral Proteins; Virus Replication | 2012 |
Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Cell Proliferation; Cells, Cultured; Coronary Vessels; Early Growth Response Protein 1; Early Growth Response Protein 2; Early Growth Response Protein 3; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Orphan Nuclear Receptors; Pertussis Toxin; Platelet-Derived Growth Factor; Primary Cell Culture; Pyridines; Receptor, Adenosine A3; Transcriptional Activation | 2012 |
Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
Topics: Adenosine; Amines; Animals; Animals, Newborn; Astrocytes; Biophysics; Coculture Techniques; CREB-Binding Protein; Culture Media, Conditioned; Cyclic AMP; Cyclohexanecarboxylic Acids; Dynamin I; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuronal Plasticity; Organ Culture Techniques; Patch-Clamp Techniques; Phosphorylation; Potassium Chloride; Presynaptic Terminals; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Statistics, Nonparametric; Synapses; Thionucleotides; Thrombospondins; Valine; Vesicular Glutamate Transport Protein 1 | 2012 |
Functional selectivity of adenosine A1 receptor ligands?
Topics: Adenosine; Animals; Arrestin; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Data Interpretation, Statistical; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Radioligand Assay; Receptor, Adenosine A1; Receptors, G-Protein-Coupled; Signal Transduction | 2013 |
Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Blotting, Western; Carbazoles; Cytochrome P-450 CYP4A; Enzyme Inhibitors; Female; Flavonoids; Hydroxyeicosatetraenoic Acids; Isometric Contraction; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth, Vascular; Protein Kinase C-alpha; Receptor, Adenosine A1 | 2013 |
IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.
Topics: Acute Kidney Injury; Adenosine; Adenosine A1 Receptor Agonists; Animals; Cell Line; Humans; Interleukin-11; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A1; Reperfusion Injury | 2013 |
Histological effect on the adipocutaneous flap in rats after preconditioning with 2-chloro-N(6) -cyclopentyladenosine.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adipose Tissue; Animals; Ischemic Preconditioning; Male; Necrosis; Rats; Rats, Wistar; Reperfusion Injury; Skin; Surgical Flaps | 2014 |
Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine.
Topics: Action Potentials; Adenosine; Alcohols; Animals; Brain Waves; Electroencephalography; Excitatory Postsynaptic Potentials; Extracellular Fluid; Hippocampus; Homeostasis; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Neurons; Purinergic P1 Receptor Antagonists; Sleep Deprivation; Sleep Stages; Theophylline; Thioinosine; Time Factors; Wakefulness | 2014 |
Pharmacological preconditioning with adenosine A(1) receptor agonist suppresses cellular immune response by an A(2A) receptor dependent mechanism.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; CD3 Complex; Cell Proliferation; Concanavalin A; Cytokines; Leukocytes; Lymphocyte Culture Test, Mixed; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mitogens; Receptor, Adenosine A1; Receptor, Adenosine A2A; Spleen; T-Lymphocytes | 2014 |
Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylaspartate; Purinergic P1 Receptor Agonists; Receptor, Adenosine A1; Xanthines | 2015 |
β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine Diphosphate; Animals; Colon; Deoxyadenine Nucleotides; Electric Stimulation; Guinea Pigs; Humans; Jejunum; Ligands; Membrane Potentials; Muscle Contraction; Muscle, Smooth; NAD; Neuromuscular Junction; Purinergic P2Y Receptor Antagonists; Receptor, Adenosine A1; Synaptic Transmission | 2015 |
Adenosine/guanosine preferring nucleoside ribohydrolase is a distinct, druggable antitrichomonal target.
Topics: Adenosine; Antitrichomonal Agents; Flavonoids; High-Throughput Screening Assays; N-Glycosyl Hydrolases; Quercetin; Small Molecule Libraries; Stereoisomerism; Trichomonas vaginalis | 2015 |
Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors.
Topics: Adenosine; Adenosine Triphosphate; Animals; Apyrase; Cells, Cultured; Excitatory Postsynaptic Potentials; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Mossy Fibers, Hippocampal; Neuronal Plasticity; Purinergic P2X Receptor Agonists; Purines; Receptors, Purinergic P2X4; Synaptic Transmission | 2016 |
Osteogenic Differentiation of Mesenchymal Stromal Cells: A Comparative Analysis Between Human Subcutaneous Adipose Tissue and Dental Pulp.
Topics: Adenosine; Adolescent; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Shape; Dental Pulp; Female; Humans; Male; Mesenchymal Stem Cells; Osteogenesis; Phenotype; Receptor, Adenosine A1; Spectrometry, X-Ray Emission; Subcutaneous Fat | 2017 |
Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling.
Topics: 5'-Nucleotidase; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Animals; Auditory Cortex; Auditory Perception; GPI-Linked Proteins; Mice; Neuronal Plasticity; Piperidines; Pyridazines; Receptor, Adenosine A1; Signal Transduction; Thalamus | 2017 |
Adenosine A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Age Factors; Animals; Animals, Newborn; Arterioles; Calcium Signaling; Cells, Cultured; Gene Expression Regulation, Developmental; Kidney; Receptor, Adenosine A1; Sus scrofa; TRPC Cation Channels; Type C Phospholipases | 2017 |
The effect of two selective A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Aminopyridines; Animals; Cardiovascular System; Consciousness; Drug Partial Agonism; Heart Rate; Hemodynamics; Ligands; Male; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Regional Blood Flow; Thiazoles; Thiophenes | 2020 |
Adenosine Receptors as Neuroinflammation Modulators: Role of A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Inflammation; Male; Neuroglia; Neurons; Rats, Wistar; Receptors, Purinergic P1; Triazines; Triazoles | 2020 |
Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Behavior, Animal; Brain; Deoxyadenosines; Disease Models, Animal; Male; Neuroprotective Agents; Organophosphate Poisoning; Rats, Sprague-Dawley; Receptor, Adenosine A1; Seizures; Soman | 2021 |
Intramuscularly administered A1 adenosine receptor agonists as delayed treatment for organophosphorus nerve agent-induced Status Epilepticus.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Anticonvulsants; Brain; Deoxyadenosines; Disease Models, Animal; Drug Administration Schedule; Injections, Intramuscular; Male; Neuroprotective Agents; Norbornanes; Rats, Sprague-Dawley; Sarin; Soman; Status Epilepticus; Time Factors | 2021 |