2-chloro-n(6)cyclopentyladenosine and 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide

2-chloro-n(6)cyclopentyladenosine has been researched along with 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide in 15 studies

Compound Research Comparison

Studies (2-chloro-n(6)cyclopentyladenosine)	Trials (2-chloro-n(6)cyclopentyladenosine)	Recent Studies (post-2010) (2-chloro-n(6)cyclopentyladenosine)	Studies (2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide)	Trials (2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide)	Recent Studies (post-2010) (2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide)
252	0	43	158	2	52

Protein Interaction Comparison

Protein	Taxonomy	2-chloro-n(6)cyclopentyladenosine (IC50)	2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide (IC50)
Adenosine receptor A3	Homo sapiens (human)		0.0017

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (13.33)	18.2507
2000's	8 (53.33)	29.6817
2010's	5 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; Ji, XD; Kim, HO; Olah, ME; Siddiqi, SM; Stiles, GL	1
Barak, D; Biadatti, T; Chen, W; Gao, ZG; Jacobson, KA; Johnson, CR; Kim, SG; Kim, SK; Lee, K	1
Gao, ZG; Jacobson, KA	1
Auchampach, JA; Finley, A; Gao, ZG; Gizewski, ET; Jacobson, KA; Moss, SM; Paoletta, S; Salvemini, D; Tosh, DK	1
Amin, EA; Dosa, PI	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K	1
Fletcher, DS; Jacobson, MA; Koller, BH; Latour, AM; Salvatore, CA; Tilley, SL	1
Burgdorf, C; Jain, D; Katus, HA; Kurz, T; Richardt, D; Richardt, G; Seyfarth, M	1
Balas, N; Jacobson, KA; Nawrath, H; Safran, N; Shainberg, A; Shneyvays, V	1
Jacobson, K; Mamedova, L; Shainberg, A; Shneyvays, V; Zinman, T	1
Cheporko, Y; Hochhauser, E; Kaminski, O; Leshem, D; Shainberg, A; Vidne, BA	1
Jacobson, KA; Liang, BT; Wang, R; Wu, D; Zambraski, E; Zheng, J	1
Guo, CX; Gupta, R; Housley, GD; Thorne, PR; Vlajkovic, SM; Wong, AC	1
Harst, A; Hinze, AV; Mayer, P; von Kügelgen, I	1

Reviews

2 review(s) available for 2-chloro-n(6)cyclopentyladenosine and 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide

Article	Year
Adenosine receptors as therapeutic targets. Nature reviews. Drug discovery, 2006, Volume: 5, Issue:3 Topics: Animals; Disease; Drug Therapy; Humans; Ligands; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Structure-Activity Relationship	2006
Tactical Approaches to Interconverting GPCR Agonists and Antagonists. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Animals; Humans; Ligands; Models, Molecular; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2016

Other Studies

13 other study(ies) available for 2-chloro-n(6)cyclopentyladenosine and 2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide

Article	Year
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	1994
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20 Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Epoxy Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ribose; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2002
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain. Journal of medicinal chemistry, 2013, Jul-25, Volume: 56, Issue:14 Topics: Adenosine A3 Receptor Agonists; Animals; CHO Cells; Chronic Pain; Cricetinae; Cricetulus; Drug Design; Male; Mice; Models, Molecular; Molecular Docking Simulation; Neuralgia; Nucleosides; Receptor, Adenosine A3; Structure-Activity Relationship	2013
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2 Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines	1997
Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells. The Journal of biological chemistry, 2000, Feb-11, Volume: 275, Issue:6 Topics: Adenosine; Animals; beta-N-Acetylhexosaminidases; Blood Pressure; Gene Targeting; Heart Rate; Inflammation; Lipopolysaccharides; Mast Cells; Mice; Mice, Knockout; Protein Binding; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Tumor Necrosis Factor-alpha; Xanthines	2000
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovascular research, 2001, Volume: 49, Issue:4 Topics: Adenosine; Analysis of Variance; Animals; Brimonidine Tartrate; Electric Stimulation; Enzyme Inhibitors; Male; Myocardial Stunning; Myocardium; Norepinephrine; Perfusion; Phenethylamines; Phenylisopropyladenosine; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Sympathetic Nervous System; Theophylline; Time Factors; Xanthines	2001
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. Molecular and cellular biochemistry, 2001, Volume: 217, Issue:1-2 Topics: Adenosine; Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; L-Lactate Dehydrogenase; Microscopy, Electron; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines	2001
Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:6 Topics: Adenosine; Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Calcium; Cells, Cultured; Doxorubicin; Electron Transport Complex IV; Heart; L-Lactate Dehydrogenase; Lipid Peroxidation; Mitochondria; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1	2001
The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart. Interactive cardiovascular and thoracic surgery, 2007, Volume: 6, Issue:3 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Analysis of Variance; Animals; Coronary Circulation; Heart; Hypertrophy; Ischemic Preconditioning, Myocardial; Male; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Adenosine A3; Reperfusion Injury	2007
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6 Topics: Adenosine; Animals; Dihydropyridines; Disease Models, Animal; Hindlimb; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Phenethylamines; Phospholipase C beta; Pyrazoles; Pyrimidines; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Signal Transduction; Xanthines	2007
Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss. Hearing research, 2010, Volume: 260, Issue:1-2 Topics: Acoustic Stimulation; Adenosine; Adenosine A1 Receptor Agonists; Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Noise-Induced; Male; Oxidative Stress; Phenethylamines; Rats; Rats, Wistar; Receptor, Adenosine A1; Time Factors; Tyrosine	2010
Adenosine A(3) receptor-induced proliferation of primary human coronary smooth muscle cells involving the induction of early growth response genes. Journal of molecular and cellular cardiology, 2012, Volume: 53, Issue:5 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Cell Proliferation; Cells, Cultured; Coronary Vessels; Early Growth Response Protein 1; Early Growth Response Protein 2; Early Growth Response Protein 3; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Orphan Nuclear Receptors; Pertussis Toxin; Platelet-Derived Growth Factor; Primary Cell Culture; Pyridines; Receptor, Adenosine A3; Transcriptional Activation	2012