Compounds > 2-chloro-n(6)-(3-iodobenzyl)adenosine-5--n-methyluronamide

2-chloro-n(6)-(3-iodobenzyl)adenosine-5--n-methyluronamide and 8-(3-chlorostyryl)caffeine

2-chloro-n(6)-(3-iodobenzyl)adenosine-5--n-methyluronamide has been researched along with 8-(3-chlorostyryl)caffeine* in 1 studies

Other Studies

1 other study(ies) available for 2-chloro-n(6)-(3-iodobenzyl)adenosine-5--n-methyluronamide and 8-(3-chlorostyryl)caffeine

Article	Year
The adenosine receptor agonist, APNEA, increases calcium influx into rat cortical synaptosomes through N-type channels associated with A2a receptors. Neurochemical research, 2000, Volume: 25, Issue:4 N6-2-(4-aminophenyl)ethyladenosine (APNEA) is a nonselective adenosine receptor agonist known to have a high affinity for the adenosine A1 and A3 receptors. It was found to be able to dose-dependently increase the sustained (4 min) Ca2+ influx into rat cortical synaptosomes while 2-chloro-N6-(3-iodobenzyl)-adenosine-5-N-methyluronamide (Cl-IB-MECA), a selective A3 agonist has no effect. However, this effect of APNEA was not affected by the presence of 8-cyclopentyl-1,3-dimethylxanthine (CPT), a selective A1 antagonist; but instead completely abolished by 8-(3-chlorostyryl)caffeine (CSC), a selective A2a antagonist, or omega-conotoxin GVIA. These results show that in the rat cortex, presynaptic A2a receptors can mediate neurotransmitter release by increasing Ca2+ influx through the N-type calcium channels. A1 and A3 receptors appear not to be involved. Topics: Adenosine; Animals; Brain Chemistry; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Cerebral Cortex; Dose-Response Relationship, Drug; Male; omega-Conotoxin GVIA; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptosomes; Xanthines	2000

Article

Year

The adenosine receptor agonist, APNEA, increases calcium influx into rat cortical synaptosomes through N-type channels associated with A2a receptors.

Neurochemical research, 2000, Volume: 25, Issue:4

N6-2-(4-aminophenyl)ethyladenosine (APNEA) is a nonselective adenosine receptor agonist known to have a high affinity for the adenosine A1 and A3 receptors. It was found to be able to dose-dependently increase the sustained (4 min) Ca2+ influx into rat cortical synaptosomes while 2-chloro-N6-(3-iodobenzyl)-adenosine-5-N-methyluronamide (Cl-IB-MECA), a selective A3 agonist has no effect. However, this effect of APNEA was not affected by the presence of 8-cyclopentyl-1,3-dimethylxanthine (CPT), a selective A1 antagonist; but instead completely abolished by 8-(3-chlorostyryl)caffeine (CSC), a selective A2a antagonist, or omega-conotoxin GVIA. These results show that in the rat cortex, presynaptic A2a receptors can mediate neurotransmitter release by increasing Ca2+ influx through the N-type calcium channels. A1 and A3 receptors appear not to be involved.

Topics: Adenosine; Animals; Brain Chemistry; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Cerebral Cortex; Dose-Response Relationship, Drug; Male; omega-Conotoxin GVIA; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptosomes; Xanthines

2000