2-butenal and carbene

N-Heterocyclic carbenes (NHC) have become an important class of organocatalysts and class of ligands for transition-metal catalysis. In organocatalyzed umpolung reactions, thiazolium salt-derived NHC have been used successfully for decades. Even so, during recent years there has been an increased interest in NHC-catalyzed transformations and many new reactions have been developed. This article focuses on the use of NHC in the conjugate umpolung of alpha,beta-unsaturated aldehydes.

Topics: Acrolein; Aldehydes; Catalysis; Chemistry, Organic; Hydrocarbons; Imines; Ketones; Ligands; Methane; Models, Molecular; Molecular Conformation; Organic Chemicals; Stereoisomerism