2-aza-2-dihydrosqualene and tridemorph

2-aza-2-dihydrosqualene has been researched along with tridemorph* in 1 studies

Other Studies

1 other study(ies) available for 2-aza-2-dihydrosqualene and tridemorph

Article	Year
Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function. Biochemical Society transactions, 1983, Volume: 11, Issue:5 25-Azacycloartanol (I), 2-aza-2-dihydrosqualene (II) and Tridemorph (2,6-dimethyl-N-tridecylmorpholine) (III) are potent inhibitors of higher plant sterol biosynthesis. The first two molecules have been designed using rational enzymological concepts. I, II and III were shown to inhibit the S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase, the 2,3-oxidosqualene: beta-amyrin-cyclase and the cycloeucalenol: obtusifoliol isomerase, respectively. Inhibition was demonstrated either in vivo on bramble cell suspensions or in vitro on microsomes from maize seedlings. Each inhibitor has been shown to have a high affinity for its presumed enzymic target and only negligible inhibitory action on the other two enzymes. The applications of these results to further physiological studies are discussed. Topics: Chemical Phenomena; Chemistry; Fabaceae; Fungicides, Industrial; Intramolecular Transferases; Isomerases; Methyltransferases; Morpholines; Phytosterols; Plants; Plants, Medicinal; Squalene; Steroid Isomerases; Structure-Activity Relationship; Zea mays	1983

Article

Year

Inhibition of 2,3-oxidosqualene: beta-amyrin-cyclase, S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase and cycloeucalenol: obtusifoliol isomerase by rationally designed molecules containing a tertiary amine function.

Biochemical Society transactions, 1983, Volume: 11, Issue:5

25-Azacycloartanol (I), 2-aza-2-dihydrosqualene (II) and Tridemorph (2,6-dimethyl-N-tridecylmorpholine) (III) are potent inhibitors of higher plant sterol biosynthesis. The first two molecules have been designed using rational enzymological concepts. I, II and III were shown to inhibit the S-adenosyl-L-methionine: cycloartenol C-24-methyltransferase, the 2,3-oxidosqualene: beta-amyrin-cyclase and the cycloeucalenol: obtusifoliol isomerase, respectively. Inhibition was demonstrated either in vivo on bramble cell suspensions or in vitro on microsomes from maize seedlings. Each inhibitor has been shown to have a high affinity for its presumed enzymic target and only negligible inhibitory action on the other two enzymes. The applications of these results to further physiological studies are discussed.

Topics: Chemical Phenomena; Chemistry; Fabaceae; Fungicides, Industrial; Intramolecular Transferases; Isomerases; Methyltransferases; Morpholines; Phytosterols; Plants; Plants, Medicinal; Squalene; Steroid Isomerases; Structure-Activity Relationship; Zea mays

1983