Page last updated: 2024-08-21

2-aminopurine and penciclovir

2-aminopurine has been researched along with penciclovir in 49 studies

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19902 (4.08)18.7374
1990's24 (48.98)18.2507
2000's14 (28.57)29.6817
2010's9 (18.37)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boyd, MR; Harnden, MR; Jarvest, RL; Sutton, D; Vere Hodge, RA2
Allen, GD; Brown, TA; Filer, CW; Fowles, SE; Hollis, FJ; Mort, EE; Ramji, JV1
Chenery, RJ; Clarke, SE; Harrell, AW1
Audet, PR; Boike, SC; Fairless, A; Freed, MI; Ilson, BE; Jorkasky, DK; Pue, M; Zariffa, N1
Fowles, SE; Laroche, J; Pratt, SK; Prince, WT1
Maung, M; Slomka, MJ; Tsiquaye, KN1
Fairless, AJ; Fowles, S; Georgiou, P; Laroche, J; Pratt, SK; Prince, W; Pue, MA1
Darlison, SJ; Readshaw, SA; Vere Hodge, RA1
Rolan, P1
Sacks, SL1
Schacke, M; Thust, R; Wutzler, P1
Whitley, RJ2
Crumpacker, C1
Reusser, P1
Fowler, SL; Goade, D; Kraus, SJ; Levin, MJ; Loveless, MO; Mertz, GJ; Tyring, SK1
Cassady, KA; Whitley, RJ1
Marks, L; Saltzman, R1
Jaeckel, E; Manns, MP1
Benfeldt, E; Borg, N; Götharson, E; Groth, L; Ståhle, L1
Sacks, SL; Wilson, B1
Keating, MR1
Bengis, RG; Cambre, RC; Hamzeh, FM; Hardy, D; Hayward, GS; Hildbrandt, T; Montali, RJ; Richman, LK; Schmitt, D; Shahkolahi, A1
Blum, HE; Hafkemeyer, P; Keppler-Hafkemeyer, A; Offensperger, S; Offensperger, WB1
Dekker, CL; Prober, CG1
De Clercq, E; Naesens, L1
Field, HJ; Gürr, WK; Littler, E; Shaw, MM; Thackray, AM; Watts, PA1
Bossi, P1
Brown, TJ; McCrary, M; Tyring, SK1
Andrei, G; De Clercq, E; Snoeck, R1
Beutner, K; Chakrabarty, A; Rauser, M; Tyring, SK1
Abdel-Haq, N; Al-Tatari, H; Asmar, B; Chearskul, P1
Hijiya, T; Izawa, K; Kojima, M; Suzuki, Y; Torii, T; Yamashita, K1
Maggs, DJ; Moulin, NK; Stanley, SD; Thomasy, SM1
Kondo, T; Kurosawa, M; Matsumura, T; Nagata, S; Nemoto, M; Tsujimura, K; Yamada, M; Yamanaka, T1
Blumer, J; Hamed, K; Kaiser, G; Rodriguez, A; Sallas, W; Sánchez, PJ1
Covert, JC; Maggs, DJ; Stanley, SD; Thomasy, SM1
Bales, JL; Ferrone, M; Maggs, DJ; Stanley, SD; Thomasy, SM; Whittem, T1
Brock, AP; Hunter, RP; Isaza, R; Koch, DE; Lindsay, WA; Montali, RJ; Richman, LK; Schmitt, DL1
Baglivo, E; Csajka, C; Daali, Y; Dayer, P; Gex-Fabry, M; Kondo-Oestreicher, M; Schenkel, F1
Contreras, MT; Groth, AD; Kado-Fong, HK; Maggs, DJ; Nguyen, KQ; Thomasy, SM1
Horvath, A; Qiu, R; Stahlmann, R1
Knych, HK; Maggs, DJ; Sebbag, L; Thomasy, SM; Woodward, AP1

Reviews

16 review(s) available for 2-aminopurine and penciclovir

ArticleYear
Pharmacokinetics of new antiherpetic agents.
    Clinical pharmacokinetics, 1995, Volume: 29, Issue:5

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Famciclovir; Guanine; Herpesviridae Infections; Humans; Prodrugs; Valacyclovir; Valine

1995
Use of penciclovir and famciclovir in the management of genital herpes.
    Current problems in dermatology, 1996, Volume: 24

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Guanine; Herpes Genitalis; Humans; Recurrence

1996
Advances in the management of herpesvirus infections. Introduction.
    Seminars in dermatology, 1996, Volume: 15, Issue:2 Suppl 1

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Guanine; Herpes Zoster; Herpesviridae Infections; Humans

1996
The pharmacological profile of famciclovir.
    Seminars in dermatology, 1996, Volume: 15, Issue:2 Suppl 1

    Topics: 2-Aminopurine; Acyclovir; Aged; Antiviral Agents; Drug Interactions; Famciclovir; Guanine; Herpes Zoster; Humans

1996
Herpesvirus resistance to antiviral drugs: a review of the mechanisms, clinical importance and therapeutic options.
    The Journal of hospital infection, 1996, Volume: 33, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Cidofovir; Cytosine; Drug Resistance, Microbial; Famciclovir; Foscarnet; Ganciclovir; Guanine; Herpesviridae; Herpesviridae Infections; Humans; Immunocompromised Host; Organophosphonates; Organophosphorus Compounds; Valacyclovir; Valine

1996
New therapeutic approaches to the alphaherpesvirus infections.
    The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:2

    Topics: 2-Aminopurine; Acyclovir; Alphaherpesvirinae; Antibodies, Monoclonal; Arabinofuranosyluracil; Cidofovir; Cytosine; Famciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Valacyclovir; Valine

1997
Experience with lamivudine against hepatitis B virus.
    Intervirology, 1997, Volume: 40, Issue:5-6

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Famciclovir; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Reverse Transcriptase Inhibitors

1997
Famciclovir/penciclovir.
    Advances in experimental medicine and biology, 1999, Volume: 458

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Guanine; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Herpes Zoster; Herpesvirus 3, Human; Humans; Immunocompromised Host; Prodrugs; Simplexvirus; Virus Replication

1999
Antiviral agents for non-human immunodeficiency virus infections.
    Mayo Clinic proceedings, 1999, Volume: 74, Issue:12

    Topics: 2-Aminopurine; Acetamides; Acyclovir; Amantadine; Antiviral Agents; Cidofovir; Cytosine; Drug Resistance, Microbial; Drugs, Investigational; Enzyme Inhibitors; Famciclovir; Foscarnet; Ganciclovir; Guanidines; Guanine; Humans; Interferons; Lamivudine; Neuraminidase; Organophosphonates; Organophosphorus Compounds; Oseltamivir; Pyrans; Ribavirin; Sialic Acids; Valacyclovir; Valine; Virus Diseases; Zanamivir

1999
Approaches to the treatment of varicella-zoster virus infections.
    Contributions to microbiology, 1999, Volume: 3

    Topics: 2-Aminopurine; Acyclovir; Adrenal Cortex Hormones; Antiviral Agents; Chickenpox; Famciclovir; Guanine; Herpes Zoster; Humans; Immunocompromised Host; Prodrugs; Valacyclovir; Valine

1999
Pediatric uses of valacyclovir, penciclovir and famciclovir.
    The Pediatric infectious disease journal, 2001, Volume: 20, Issue:11

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Child; Drug Approval; Famciclovir; Guanine; Herpesviridae Infections; Humans; Immunocompetence; United States; United States Food and Drug Administration; Valacyclovir; Valine

2001
Recent developments in herpesvirus therapy.
    Herpes : the journal of the IHMF, 2001, Volume: 8, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Clinical Trials as Topic; Cytosine; Famciclovir; Foscarnet; Ganciclovir; Guanine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valacyclovir; Valine

2001
[Genital herpes: epidemiology, transmission, clinic, asymptomatic viral excretion, impact on other sexually transmitted diseases, prevention, and treatment].
    Annales de dermatologie et de venereologie, 2002, Volume: 129, Issue:4 Pt 2

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Drug Therapy, Combination; Famciclovir; Female; France; Guanine; Herpes Genitalis; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Male; Patient Education as Topic; Risk Factors; Valacyclovir; Valine; Virus Shedding

2002
Antiviral agents: Non-antiretroviral [correction of Nonantiviral] drugs.
    Journal of the American Academy of Dermatology, 2002, Volume: 47, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Chickenpox; Cytomegalovirus Infections; Famciclovir; Foscarnet; Guanine; Hepatitis B; Hepatitis C; Herpes Genitalis; Herpes Simplex; Herpesvirus 3, Human; Herpesvirus 8, Human; Humans; Papillomavirus Infections; Sarcoma, Kaposi; Skin Diseases, Viral; Valacyclovir; Valine

2002
Recent clinical experience with famciclovir--a "third generation" nucleoside prodrug.
    Antiviral chemistry & chemotherapy, 2004, Volume: 15, Issue:5

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Biological Availability; Clinical Trials as Topic; Famciclovir; Guanine; Herpes Genitalis; Herpes Zoster; Humans; Male; Nervous System; Prodrugs

2004
New antiviral agents.
    Indian journal of pediatrics, 2006, Volume: 73, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Aminoquinolines; Antiviral Agents; Bromodeoxyuridine; Famciclovir; Fatty Alcohols; Ganciclovir; Guanine; Humans; Imiquimod; Valganciclovir; Virus Diseases

2006

Trials

7 trial(s) available for 2-aminopurine and penciclovir

ArticleYear
Linear pharmacokinetics of penciclovir following administration of single oral doses of famciclovir 125, 250, 500 and 750 mg to healthy volunteers.
    The Journal of antimicrobial chemotherapy, 1994, Volume: 33, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adult; Antiviral Agents; Chromatography, High Pressure Liquid; Famciclovir; Guanine; Half-Life; Humans; Male; Middle Aged; Prodrugs; Single-Blind Method; Spectrophotometry, Ultraviolet

1994
Oral famciclovir for suppression of recurrent genital herpes simplex virus infection in women. A multicenter, double-blind, placebo-controlled trial. Collaborative Famciclovir Genital Herpes Research Group.
    Archives of internal medicine, 1997, Feb-10, Volume: 157, Issue:3

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adult; Antigen-Antibody Complex; Antiviral Agents; Double-Blind Method; Famciclovir; Female; Guanine; Herpes Genitalis; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Recurrence; Simplexvirus; Treatment Outcome

1997
Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: comparison of the suction blister technique and cutaneous microdialysis.
    Acta dermato-venereologica, 1999, Volume: 79, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adult; Antiviral Agents; Blister; Dialysis Solutions; Epinephrine; Famciclovir; Female; Guanine; Humans; Male; Microdialysis; Prodrugs; Skin; Temperature; Time Factors; Tissue Distribution; Vasoconstrictor Agents

1999
Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats.
    American journal of veterinary research, 2007, Volume: 68, Issue:11

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Cats; Cross-Over Studies; Drug Interactions; Famciclovir; Female; Guanine; Half-Life; Prodrugs; Specific Pathogen-Free Organisms

2007
Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and children.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Antiviral Agents; Body Weight; Capsules; Child; Child, Preschool; Famciclovir; Female; Guanine; Herpes Simplex; Humans; Infant, Newborn; Male; Models, Biological

2010
Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study.
    Veterinary ophthalmology, 2012, Volume: 15, Issue:5

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Antiviral Agents; Cats; Dose-Response Relationship, Drug; Eye Diseases; Famciclovir; Guanine; Herpesviridae Infections; Pilot Projects; Specimen Handling; Tears

2012
Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir.
    American journal of veterinary research, 2016, Volume: 77, Issue:8

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Cats; Cross-Over Studies; Dose-Response Relationship, Drug; Famciclovir; Guanine; Male; Specific Pathogen-Free Organisms; Tears

2016

Other Studies

26 other study(ies) available for 2-aminopurine and penciclovir

ArticleYear
Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir].
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:10

    Topics: 2-Aminopurine; Acyclovir; Adenine; Animals; Antiviral Agents; Bile; Biological Availability; Chromatography, High Pressure Liquid; Duodenum; Famciclovir; Guanine; Humans; In Vitro Techniques; Intestinal Mucosa; Liver; Male; Prodrugs; Rats; Tissue Distribution

1989
Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:8

    Topics: 2-Aminopurine; Acyclovir; Adenine; Animals; Antiviral Agents; Chemical Phenomena; Chemistry; Famciclovir; Guanine; Intestinal Absorption; Mice; Prodrugs

1989
Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog.
    Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:5

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Biotransformation; Blood Proteins; Chromatography, High Pressure Liquid; Dogs; Famciclovir; Feces; Guanine; Male; Mass Spectrometry; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrophotometry, Ultraviolet

1995
Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:2

    Topics: 2-Aminopurine; Acyclovir; Aldehyde Oxidase; Aldehyde Oxidoreductases; Allopurinol; Antiviral Agents; Benzaldehydes; Cytosol; Famciclovir; Guanine; Humans; Kinetics; Liver; Oxidation-Reduction; Prodrugs; Vitamin K; Xanthine Oxidase

1995
Pharmacokinetics of famciclovir in subjects with chronic hepatic disease.
    Journal of clinical pharmacology, 1994, Volume: 34, Issue:12

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adolescent; Adult; Biological Availability; Chromatography, High Pressure Liquid; Chronic Disease; Famciclovir; Female; Guanine; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Prodrugs

1994
Lack of a pharmacokinetic interaction between oral famciclovir and allopurinol in healthy volunteers.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adult; Allopurinol; Antiviral Agents; Drug Interactions; Famciclovir; Guanine; Half-Life; Humans; Male; Middle Aged; Oxypurinol

1994
Oral famciclovir against duck hepatitis B virus replication in hepatic and nonhepatic tissues of ducklings infected in ovo.
    Journal of medical virology, 1994, Volume: 42, Issue:3

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Animals, Newborn; Antiviral Agents; Biotransformation; Disease Models, Animal; DNA, Viral; Ducks; Eggs; Famciclovir; Guanine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Kidney; Liver; Organ Specificity; Pancreas; Poultry Diseases; Prodrugs; Spleen; Viremia; Virus Replication; Xanthine Oxidase

1994
Use of isotopically chiral [4'-13C]famciclovir and 13C NMR to identify the chiral monoacetylated intermediates in the conversion of famciclovir to penciclovir by human intestinal wall extract.
    Chirality, 1993, Volume: 5, Issue:8

    Topics: 2-Aminopurine; Acetylation; Acyclovir; Antiviral Agents; Biotransformation; Carbon Isotopes; Famciclovir; Guanine; Humans; In Vitro Techniques; Intestine, Small; Magnetic Resonance Spectroscopy; Prodrugs; Stereoisomerism; Tissue Extracts

1993
Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues.
    Antiviral research, 1996, Volume: 31, Issue:1-2

    Topics: 2-Aminopurine; Acyclovir; Animals; CHO Cells; Cricetinae; Famciclovir; Ganciclovir; Guanine; Mutagenicity Tests; Mutagens; Valacyclovir; Valine

1996
Drugs for non-HIV viral infections.
    The Medical letter on drugs and therapeutics, 1997, Aug-01, Volume: 39, Issue:1006

    Topics: 2-Aminopurine; Abnormalities, Drug-Induced; Acyclovir; Amantadine; Antiviral Agents; Cidofovir; Contraindications; Cytosine; Drug Resistance, Microbial; Eye Infections, Viral; Famciclovir; Foscarnet; Ganciclovir; Guanine; Humans; Interferon-alpha; Kidney Diseases; Lamivudine; Organophosphonates; Organophosphorus Compounds; Prodrugs; Ribavirin; Rimantadine; Trifluridine; Valacyclovir; Valine; Virus Diseases

1997
Contempo 1997: dermatology.
    JAMA, 1997, Oct-08, Volume: 278, Issue:14

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Guanine; Herpes Labialis; Herpes Zoster; Humans; Valacyclovir; Valine

1997
Clinical and pathological findings of a newly recognized disease of elephants caused by endotheliotropic herpesviruses.
    Journal of wildlife diseases, 2000, Volume: 36, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Animals; Animals, Zoo; Antiviral Agents; DNA, Viral; Elephants; Endothelium, Vascular; Famciclovir; Female; Guanine; Herpesviridae; Herpesviridae Infections; Liver; Lung; Male; Myocardium; North America; Polymerase Chain Reaction; Prodrugs; Retrospective Studies; Tongue

2000
Drugs for non-HIV viral infections.
    The Medical letter on drugs and therapeutics, 1999, Dec-03, Volume: 41, Issue:1067

    Topics: 2-Aminopurine; Acetamides; Acyclovir; Aged; Amantadine; Animals; Anti-HIV Agents; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enzyme Inhibitors; Famciclovir; Ganciclovir; Guanidines; Guanine; Herpes Simplex; Herpes Zoster; History, 18th Century; HIV Infections; Humans; Injections, Intravenous; Interferon-alpha; Lamivudine; Neuraminidase; Oseltamivir; Pyrans; Rats; Ribavirin; Sialic Acids; Teratogens; Valacyclovir; Valine; Zanamivir

1999
Herpes drugs fetch R11.4 bil.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2000, Volume: 90, Issue:10

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Drug Industry; Famciclovir; Guanine; Humans; South Africa

2000
Antiviral activities of penciclovir and famciclovir on duck hepatitis B virus in vitro and in vivo.
    Antiviral therapy, 1996, Volume: 1, Issue:3

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Ducks; Famciclovir; Guanine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Hepatocytes; Virus Replication

1996
Drugs for non-HIV viral infections.
    The Medical letter on drugs and therapeutics, 2002, Feb-04, Volume: 44, Issue:1123

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Administration, Topical; Amantadine; Animals; Antiviral Agents; Cidofovir; Cytosine; Famciclovir; Foscarnet; Guanine; Herpesviridae Infections; Humans; Influenza, Human; Injections, Intravenous; Lamivudine; Organophosphonates; Organophosphorus Compounds; Rats; Ribavirin; Rimantadine; Thionucleotides; Trifluridine; Valacyclovir; Valine

2002
Temporal pattern of herpes simplex virus type 1 infection and cell death in the mouse brain stem: influence of guanosine nucleoside analogues.
    Journal of virological methods, 2002, Volume: 102, Issue:1-2

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Apoptosis; Brain Stem; Disease Models, Animal; DNA Fragmentation; Famciclovir; Female; Ganciclovir; Guanine; Herpes Simplex; Herpesvirus 1, Human; Humans; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Valacyclovir; Valine

2002
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
    Antiviral research, 2004, Volume: 61, Issue:3

    Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins

2004
Drugs for non-HIV viral infections.
    Treatment guidelines from the Medical Letter, 2005, Volume: 3, Issue:32

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Cytomegalovirus Infections; Drug Resistance, Viral; Famciclovir; Guanine; Hepatitis B; Hepatitis C; Herpes Simplex; Herpes Zoster; Humans; Influenza, Human; Valacyclovir; Valine; Virus Diseases

2005
Improved industrial syntheses of penciclovir and famciclovir using N2-acetyl-7-benzylguanine and a cyclic side chain precursor.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:4-6

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Famciclovir; Guanine; Molecular Structure; Prodrugs

2006
Pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses.
    The Journal of veterinary medical science, 2010, Volume: 72, Issue:3

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Famciclovir; Guanine; Half-Life; Herpesviridae Infections; Herpesvirus 1, Equid; Horse Diseases; Horses

2010
Pharmacokinetics of penciclovir in healthy cats following oral administration of famciclovir or intravenous infusion of penciclovir.
    American journal of veterinary research, 2012, Volume: 73, Issue:7

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cats; Cross-Over Studies; Famciclovir; Female; Guanine; Half-Life; Male; Prodrugs

2012
Estimates of the pharmacokinetics of famciclovir and its active metabolite penciclovir in young Asian elephants (Elephas maximus).
    American journal of veterinary research, 2012, Volume: 73, Issue:12

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Administration, Rectal; Animals; Antiviral Agents; Area Under Curve; Chromatography, Liquid; Cross-Over Studies; Elephants; Famciclovir; Female; Guanine; Half-Life; Male; Mass Spectrometry

2012
Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model.
    The Journal of antimicrobial chemotherapy, 2013, Volume: 68, Issue:7

    Topics: 2-Aminopurine; Acyclovir; Administration, Oral; Adult; Aged; Aged, 80 and over; Antiviral Agents; Aqueous Humor; Famciclovir; Female; Guanine; Humans; Male; Middle Aged; Models, Statistical; Plasma

2013
In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites.
    Veterinary ophthalmology, 2014, Volume: 17, Issue:4

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Cats; Cell Line; Dose-Response Relationship, Drug; Famciclovir; Guanine; Herpesviridae; Inhibitory Concentration 50; Viral Plaque Assay

2014
Effects of four nucleoside analogues used as antiviral agents on rat Sertoli cells (SerW3) in vitro.
    Archives of toxicology, 2016, Volume: 90, Issue:8

    Topics: 2-Aminopurine; Acyclovir; Animals; Antiviral Agents; Biomarkers; Blotting, Western; Cadherins; Cell Culture Techniques; Cell Line; Connexin 43; Dose-Response Relationship, Drug; Famciclovir; Ganciclovir; Guanine; Male; Microscopy, Fluorescence; Nerve Tissue Proteins; Rats; Sertoli Cells; Vimentin

2016