Compounds > 2-aminomethyl-4-tert-butyl-6-propionylphenol
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2-aminomethyl-4-tert-butyl-6-propionylphenol and indomethacin

2-aminomethyl-4-tert-butyl-6-propionylphenol has been researched along with indomethacin in 3 studies

*Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. [MeSH]

*Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. [MeSH]

Compound Research Comparison

Studies
(2-aminomethyl-4-tert-butyl-6-propionylphenol)		Trials
(2-aminomethyl-4-tert-butyl-6-propionylphenol)		Recent Studies (post-2010)
(2-aminomethyl-4-tert-butyl-6-propionylphenol)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
100029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomy2-aminomethyl-4-tert-butyl-6-propionylphenol (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asano, T; Hanamura, T; Johshita, H; Takakura, K1
Hess, ML; Ito, H; Kato, Y; Kohno, H; Okabe, E1
Aishita, H; Miura, Y; Miyamoto, T; Mizushima, Y; Morimura, T; Obata, T; Tsuboshima, M1

Other Studies

3 other study(ies) available for 2-aminomethyl-4-tert-butyl-6-propionylphenol and indomethacin

ArticleYear
Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats.
    Stroke, 1989, Volume: 20, Issue:6

    Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Constriction; Female; Indomethacin; Male; Propiophenones; Reperfusion; Specific Gravity

1989
Inhibition by free radical scavengers and by cyclooxygenase inhibitors of the effect of acidosis on calcium transport by masseter muscle sarcoplasmic reticulum.
    Biochemical pharmacology, 1985, Apr-01, Volume: 34, Issue:7

    Topics: Acidosis; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Cyclooxygenase Inhibitors; Dogs; Free Radicals; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Mannitol; Masseter Muscle; Masticatory Muscles; Propiophenones; Sarcoplasmic Reticulum; Superoxide Dismutase; Superoxides

1985
ONO-3144, a new anti-inflammatory drug and its possible mechanism of action.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 261, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Autolysis; Capillary Permeability; Edema; Hydrogen Peroxide; Indomethacin; Lipid Peroxides; Male; Mice; Phenylbutazone; Propiophenones; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thromboxane-A Synthase

1983