Compounds > 2-aminomethyl-4-t-butyl-6-iodophenol
Page last updated: 2024-09-03

2-aminomethyl-4-t-butyl-6-iodophenol and indomethacin

2-aminomethyl-4-t-butyl-6-iodophenol has been researched along with indomethacin in 7 studies

Compound Research Comparison

Studies
(2-aminomethyl-4-t-butyl-6-iodophenol)		Trials
(2-aminomethyl-4-t-butyl-6-iodophenol)		Recent Studies (post-2010)
(2-aminomethyl-4-t-butyl-6-iodophenol)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
410129,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomy2-aminomethyl-4-t-butyl-6-iodophenol (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Harada, Y; Katori, M; Kawamura, M1
Caplan, M; Hess, ML; Lucchesi, B; Romson, JL; Rowe, GT1
Benoni, G; Del Soldato, P; Foschi, D; Scarpignato, C1
Mahmud, I; Miura, Y1
Davis, BB; Mattammal, MB; Rice, JR; Wise, RW; Zenser, TV1
Harada, Y; Katori, M; Tanaka, K1
Bell-Quilley, CP; Drugge, ED; Hilchey, SD; Lin, YS; McGiff, JC1

Other Studies

7 other study(ies) available for 2-aminomethyl-4-t-butyl-6-iodophenol and indomethacin

ArticleYear
Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butylated Hydroxytoluene; Epoprostenol; Indomethacin; Male; Rabbits; Thromboxane B2

1991
Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion.
    Advances in myocardiology, 1985, Volume: 5

    Topics: Adenosine Triphosphatases; Animals; Butylated Hydroxytoluene; Calcium; Catalase; Dogs; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Ibuprofen; Indomethacin; Leukocytes; Male; Mannitol; Myocardial Infarction; Myocardium; Neutrophils; Sarcoplasmic Reticulum; Superoxide Dismutase; Tetradecanoylphorbol Acetate

1985
Oxygen free radicals interact with indomethacin to cause gastrointestinal injury.
    Agents and actions, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents; Butylated Hydroxytoluene; Digestive System; Dinoprostone; Ethanol; Female; Free Radicals; Indomethacin; Oxygen; Peptic Ulcer; Prostaglandins E; Rats; Stomach Ulcer

1986
Effects of stimulators and inhibitors on arachidonic acid metabolism in hepatoma.
    Cellular and molecular biology, including cyto-enzymology, 1981, Volume: 27, Issue:2-3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxytoluene; Carcinoma, Hepatocellular; Indomethacin; Liver Neoplasms; Prostaglandins; Rats; Sodium Salicylate; Thromboxane B2; Thromboxanes; Tryptophan

1981
Prostaglandin H synthase-catalyzed activation of benzidine: a model to assess pharmacologic intervention of the initiation of chemical carcinogenesis.
    The Journal of pharmacology and experimental therapeutics, 1983, Volume: 227, Issue:3

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Ascorbic Acid; Benzidines; Binding Sites; Butylated Hydroxytoluene; Carcinogens; Dose-Response Relationship, Drug; Drug Interactions; Indomethacin; Male; Methimazole; Microsomes; Models, Chemical; Peroxidases; Propylthiouracil; Prostaglandin Endoperoxides; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Protein Binding; Pyrazoles; Rabbits; Stimulation, Chemical

1983
Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447.
    Japanese journal of pharmacology, 1981, Volume: 31, Issue:5

    Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Butylated Hydroxytoluene; Collagen; Epoprostenol; Indomethacin; Male; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandins; Rats; Rats, Inbred Strains

1981
Renovascular actions of angiotensin II in the isolated kidney of the rat: relationship to lipoxygenases.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Butylated Hydroxytoluene; Cyclooxygenase Inhibitors; Filtration; Flavanones; Flavonoids; Glomerular Filtration Rate; In Vitro Techniques; Indomethacin; Kidney; Lipoxygenase; Lipoxygenase Inhibitors; Male; Perfusion; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Vascular Resistance

1993