2-aminobicyclo(2,2,1)heptane-2-carboxylic acid and ubenimex

2-aminobicyclo(2,2,1)heptane-2-carboxylic acid has been researched along with ubenimex in 2 studies

Compound Research Comparison

Studies (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Trials (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Recent Studies (post-2010) (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Studies (ubenimex)	Trials (ubenimex)	Recent Studies (post-2010) (ubenimex)
166	0	34	930	43	182

Protein Interaction Comparison

Protein	Taxonomy	ubenimex (IC50)
Aminopeptidase B	Rattus norvegicus (Norway rat)	6
M1 family aminopeptidase	Plasmodium falciparum FcB1/Columbia	0.284
Cytosol aminopeptidase	Bos taurus (cattle)	1.0005
72 kDa type IV collagenase	Homo sapiens (human)	6.45
Leukotriene A-4 hydrolase	Homo sapiens (human)	1.4742
Aminopeptidase N	Homo sapiens (human)	2.6333
Aminopeptidase N	Sus scrofa (pig)	3.8211
Angiotensin-converting enzyme	Rattus norvegicus (Norway rat)	2.7
Puromycin-sensitive aminopeptidase	Homo sapiens (human)	3.5
Bacterial leucyl aminopeptidase	Vibrio proteolyticus	1.0005

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Authors

Authors	Studies
Denny, WA; Gynther, M; Huttunen, J; Huttunen, KM; Puris, E; Spicer, JA	1
Huttunen, J; Huttunen, KM; Markowicz-Piasecka, M; Montaser, A	1

Other Studies

2 other study(ies) available for 2-aminobicyclo(2,2,1)heptane-2-carboxylic acid and ubenimex

Article	Year
A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells. Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Large Neutral Amino Acid-Transporter 1; Male; MCF-7 Cells; Mice; Molecular Structure; Prostatic Neoplasms; Pyridines; Structure-Activity Relationship	2016
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. Apoptosis : an international journal on programmed cell death, 2020, Volume: 25, Issue:5-6 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Brain; Brain Chemistry; Carboxylic Acids; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Injections, Intraperitoneal; Large Neutral Amino Acid-Transporter 1; Leucine; Male; MCF-7 Cells; Mice; Myocytes, Smooth Muscle; NF-kappa B; Norbornanes; Primary Cell Culture; Pyridines; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tyrosine	2020

Article

Year

A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells.

Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Large Neutral Amino Acid-Transporter 1; Male; MCF-7 Cells; Mice; Molecular Structure; Prostatic Neoplasms; Pyridines; Structure-Activity Relationship

2016

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.

Apoptosis : an international journal on programmed cell death, 2020, Volume: 25, Issue:5-6

Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Brain; Brain Chemistry; Carboxylic Acids; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Injections, Intraperitoneal; Large Neutral Amino Acid-Transporter 1; Leucine; Male; MCF-7 Cells; Mice; Myocytes, Smooth Muscle; NF-kappa B; Norbornanes; Primary Cell Culture; Pyridines; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tyrosine

2020