2-aminobicyclo(2,2,1)heptane-2-carboxylic acid and leucine

2-aminobicyclo(2,2,1)heptane-2-carboxylic acid has been researched along with leucine in 62 studies

Compound Research Comparison

Studies (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Trials (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Recent Studies (post-2010) (2-aminobicyclo(2,2,1)heptane-2-carboxylic acid)	Studies (leucine)	Trials (leucine)	Recent Studies (post-2010) (leucine)
166	0	34	28,515	744	4,178

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (30.65)	18.7374
1990's	11 (17.74)	18.2507
2000's	18 (29.03)	29.6817
2010's	13 (20.97)	24.3611
2020's	1 (1.61)	2.80

Authors

Authors	Studies
Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H	1
Denny, WA; Gynther, M; Huttunen, J; Huttunen, KM; Puris, E; Spicer, JA	1
Ishida, H; Panten, U	1
Gylfe, E	2
Malaisse, WJ; Sener, A	2
Erecińska, M; Nelson, D	1
Mitsumoto, Y; Mohri, T	2
Fahien, CM; Fahien, LA; Macdonald, MJ; Teller, JK	1
Barreto, M; Malaisse, WJ; Sener, A; Valverde, I	1
Beezley, D; Beyer, J; Pautler, EL; Tengerdy, C	1
Blachier, F; Leclercq-Meyer, V; Malaisse, WJ; Marchand, J; Sener, A	1
Harper, AE; Tews, JK; Torres, N; Tovar, A	1
Leong, MK; Ng, FH; Tan, CH; Thiyagarajah, P	1
Erecinska, M; Wilson, DF; Zaleski, J	2
Knowles, RG; Pogson, CI; Salter, M	1
Christensen, HN; Tager, HS	1
Malaisse, WJ; Malaisse-Lagae, F; Sener, A	1
Lichtman, MA; Segel, GB	1
Holze, S; Lenzen, S; Panten, U	1
Handlogten, ME; Kilberg, MS; Weissbach, L	1
Pearson, JD; Sepúlveda, FV	1
Malaisse, WJ; Ramirez, R; Sener, A	1
Hawkins, RA; Peterson, DR; Sánchez del Pino, MM	1
Bosco, D; Malaisse, WJ; Meda, P; Thorens, B	1
McNeillie, SA; Shennan, DB	1
Peters, MS; Prather, RS; Van Winkle, LJ	1
Iguchi, T; Iwashita, M; Kudo, Y; Takeda, Y	1
Gao, ZY; Li, G; Matschinsky, FM; Najafi, H; Wolf, BA	1
Cheng, JK; Eisenach, JC; Pan, HL	1
Friedrich, M; Halfter, H; Kopka, K; Riemann, B; Ringelstein, EB; Schober, O; Stögbauer, F; Weckesser, M; Winters, S	1
Cruz, WS; Kwon, G; Marshall, CA; McDaniel, ML; Xu, G	1
Baab, PJ; Collins, RM; Zielke, CL; Zielke, HR	1
Anzai, N; Babu, E; Chairoungdua, A; Choi, HW; Endou, H; Iribe, Y; Kanai, Y; Kim, DK; Tachampa, K; Tangtrongsup, S	1
Horie, S; Murayama, T; Nemoto, T; Nomura, Y; Okuma, Y; Saito, T; Shimma, N	1
Cheng, H; Drought, H; Liu, YJ; MacDonald, MJ; Sharp, GW; Straub, SG	1
Akaishi, R; Fujimura, S; Furuya, N; Kadowaki, M; Kanazawa, T; Taneike, I; Yoshizawa, F	1
Bartley, C; Carobbio, S; Fernandez-Pascual, S; Ishihara, H; Maechler, P; Martin-Del-Rio, R	1
Chun, HS; Endou, H; Jung, HM; Kanai, Y; Kim, BY; Kim, DK; Kim, MS; Kim, SG; Kim, YB; Ko, YM; Kook, JK; Lee, SH; Park, JC; Yoo, H; Yoon, JH	1
Ahn, SG; Bae, CS; Endou, H; Hwang, S; Kanai, Y; Kim, DK; Kim, IJ; Kim, JK; Kim, SA; Kook, JH; Lee, MC; Shin, BA; Yoon, JH	1
Gynther, M; Järvinen, T; Laine, K; Leppänen, J; Mannila, A; Nevalainen, T; Rautio, J; Ropponen, J; Savolainen, J	1
Kanai, Y; Kobayashi, K; Nagane, M; Ohnishi, A; Promsuk, J; Shimizu, S; Shiokawa, Y	1
Cho, SH; Chun, HS; Endou, H; Kanai, Y; Kim, CS; Kim, DK; Lee, SY	1
Berezowski, V; Cecchelli, R; Czeredys, M; Kulikova, N; Mysiorek, C; Nałecz, KA; Samluk, Ł	1
Shennan, DB; Thomson, J	1
Kanai, Y; Kimura, T; Kohno, N; Nagamori, S; Sakurai, H; Wiriyasermkul, P; Yamauchi, K	1
Akimoto, Y; Anzai, N; Horita, A; Iwashita, M; Jin, CJ; Kabir-Salmani, M; Kaji, M; Kanai, Y; Sakamoto, A; Sakurai, H	1
Cabral, JM; Pinho, MJ; Serrão, MP; Silva, E; Soares-da-Silva, P	1
Imai, H; Ishizuka, T; Kaira, K; Kanai, Y; Mori, M; Nagamori, S; Nakajima, T; Oriuchi, N; Promchan, K; Shimizu, K; Sunaga, N; Tominaga, H; Yamamoto, N; Yanagitani, N	1
Chand, AL; Legge, M	1
Matsuo, H; Nawashiro, H; Nomura, N; Osada, H; Otani, N; Shinomiya, N; Takeuchi, S; Toyooka, T; Wada, K	1
Auten, RL; Brahmajothi, MV; McMahon, TJ; Tinch, BT; Torok, JA; Zhu, H	1
Bailey, CG; Beaumont, KA; Font, J; Haass, NK; Holst, J; Jormakka, M; Otte, NJ; Rasko, JE; Ryan, RM; Sharp, DM; Tiffen, JC; van Geldermalsen, M; Wang, Q	1
Borwornpinyo, S; Chairoungdua, A; Hongeng, S; Janpipatkul, K; Jearawiriyapaisarn, N; Piyachaturawat, P; Suksen, K	1
Ishikawa, T; Kadota, Y; Kitaura, Y; Kondo, Y; Nakamura, K; Shimomura, Y; Xu, M; Zhen, H	1
Liang, H; Luo, W; Ma, J; Tan, D; Tan, Y; Wang, J; Wang, X; Zhang, Q	1
Akosman, I; Dosier, LBM; McMahon, TJ; Premkumar, VJ; Wempe, MF; Zhu, H	1
Jihong, P; Lin, W; Rui, Z; Yu, Z	1
Huttunen, J; Huttunen, KM; Markowicz-Piasecka, M; Montaser, A	1

Other Studies

62 other study(ies) available for 2-aminobicyclo(2,2,1)heptane-2-carboxylic acid and leucine

Article	Year
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. The Journal of biological chemistry, 2001, May-18, Volume: 276, Issue:20 Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis	2001
A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells. Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12 Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Large Neutral Amino Acid-Transporter 1; Male; MCF-7 Cells; Mice; Molecular Structure; Prostatic Neoplasms; Pyridines; Structure-Activity Relationship	2016
Fluorescence of oxidized flavoproteins from perifused isolated pancreatic islets. Diabetologia, 1975, Volume: 11, Issue:6 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arginine; Caproates; Female; Flavin-Adenine Dinucleotide; Glucose; Islets of Langerhans; Keto Acids; Leucine; Male; Mice; Mice, Obese; Microscopy, Fluorescence; Mitochondria; NAD; NADP; Norbornanes; Oxidation-Reduction; Pentobarbital	1975
Specific glucose protection of pancreatic beta-cell function during culture in chemically defined medium. Endocrinology, 1977, Volume: 101, Issue:4 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Bridged Bicyclo Compounds; Calcium; Culture Media; Glucose; Insulin; Islets of Langerhans; Leucine; Mice; Mice, Obese	1977
Hexose metabolism in pancreatic islets. Activation of the Krebs cycle by nutrient secretagogues. Molecular and cellular biochemistry, 1991, Oct-16, Volume: 107, Issue:2 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Calcium; Citric Acid Cycle; Fructose; Glucose; Islets of Langerhans; Keto Acids; Leucine; Mitochondria; Oxidation-Reduction; Phenylpyruvic Acids; Rats	1991
Activation of glutamate dehydrogenase by leucine and its nonmetabolizable analogue in rat brain synaptosomes. Journal of neurochemistry, 1990, Volume: 54, Issue:4 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Brain; Enzyme Activation; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ketoglutaric Acids; Leucine; Oxidation-Reduction; Oxygen Consumption; Rats; Synaptosomes	1990
Reconstitution of the L-leucine-H+ cotransporter of the plasma membrane from Chang liver cells into proteoliposomes. Biochimica et biophysica acta, 1991, Jan-30, Volume: 1061, Issue:2 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carrier Proteins; Cell Membrane; Cells, Cultured; Escherichia coli Proteins; Glucosides; Hydrogen-Ion Concentration; Kinetics; Leucine; Liposomes; Liver; Periplasmic Binding Proteins; Solubility; Valinomycin	1991
Regulation of glutamate dehydrogenase by Mg2+ and magnification of leucine activation by Mg2+. Molecular pharmacology, 1990, Volume: 37, Issue:6 Topics: Allosteric Regulation; Amino Acids; Amino Acids, Cyclic; Enzyme Activation; Glutamate Dehydrogenase; Humans; Ketoglutaric Acids; Kinetics; Leucine; Liver; Magnesium; Male; Ornithine Carbamoyltransferase	1990
Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:10 Topics: Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Keto Acids; Leucine; Neoplasm Proteins; Pancreatic Neoplasms; Phenylalanine; Serine; Tumor Cells, Cultured	1989
Modification of leucine transport across bovine pigment epithelium by metabolic stress. The American journal of physiology, 1989, Volume: 257, Issue:5 Pt 1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport; Cattle; Dinitrophenols; Electrophysiology; Leucine; Oxygen; Partial Pressure; Pigment Epithelium of Eye	1989
Effects of L-leucine, its 2-keto acid metabolite and its non-metabolized analogue on rat tumoral islet cell function. Journal of molecular endocrinology, 1988, Volume: 1, Issue:1 Topics: Adenine Nucleotides; Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Animals; Calcium Radioisotopes; Cell Line; Insulin; Insulinoma; Keto Acids; Leucine; Phosphatidylinositols; Phosphorus Radioisotopes; Rats; Rubidium Radioisotopes; Time Factors; Tumor Cells, Cultured	1988
Leucine transport in relation to the activities of Na+-H+ antiporter and Na+/K+ pump stimulated by serum and a tumor promoter. Biochimica et biophysica acta, 1986, Sep-25, Volume: 861, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport, Active; Blood; Carrier Proteins; Hydrogen-Ion Concentration; Leucine; Liver; Monensin; Ouabain; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate	1986
Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells. The Journal of biological chemistry, 1988, Sep-25, Volume: 263, Issue:27 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arginine; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Mice; Mice, Obese; Obesity	1988
Some characteristics of threonine transport across the blood-brain barrier of the rat. Journal of neurochemistry, 1988, Volume: 51, Issue:4 Topics: Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Animals; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Cysteine; Leucine; Male; Phenylalanine; Rats; Rats, Inbred Strains; Serine; Sodium; Threonine	1988
Sodium-independent synaptosomal uptake of leucine. Biochemistry international, 1987, Volume: 14, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Brain; In Vitro Techniques; Kinetics; Leucine; Male; Rats; Rats, Inbred Strains; Sodium; Synaptosomes	1987
Glutamine metabolism in rat hepatocytes. Stimulation by a nonmetabolizable analog of leucine. The Journal of biological chemistry, 1986, Oct-25, Volume: 261, Issue:30 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Amino Acids, Cyclic; Animals; Glucagon; Glutamine; Hydroxybutyrates; Ketoglutaric Acids; Leucine; Liver; Malates; Ornithine; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Urea	1986
beta-2-Aminobicyclo-(2.2.1)-heptane-2-carboxylic acid. A new activator of glutaminase in intact rat liver mitochondria. The Journal of biological chemistry, 1986, Oct-25, Volume: 261, Issue:30 Topics: Amino Acids; Amino Acids, Cyclic; Ammonium Chloride; Animals; Cell Fractionation; Enzyme Activation; Glutaminase; Leucine; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains	1986
Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems. The Biochemical journal, 1986, Jan-15, Volume: 233, Issue:2 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport; Cell Membrane; In Vitro Techniques; Kinetics; Leucine; Liver; Male; Phenylalanine; Rats; Rats, Inbred Strains; Tryptophan; Tyrosine	1986
Hypoglycemic action of 2-aminonorbornane-2-carboxylic acid in the rat. Biochemical and biophysical research communications, 1971, Jul-02, Volume: 44, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding Sites; Blood Glucose; Drug Synergism; Hypoglycemia; Insulin; Insulin Secretion; Kinetics; Leucine; Male; Rats; Stereoisomerism; Structure-Activity Relationship; Terpenes; Tolbutamide	1971
The stimulus-secretion coupling of amino acid-induced insulin release. XII. Contrasting effects of L-leucine and a nonmetabolized analog upon islet metabolism and insulin secretion. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1982, Volume: 14, Issue:9 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Oxidation-Reduction; Rats	1982
The stimulus-secretion coupling of amino acid-induced insulin release: insulinotropic action of branched-chain amino acids at physiological concentrations of glucose and glutamine. European journal of clinical investigation, 1981, Volume: 11, Issue:6 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Culture Media; Enzyme Activation; Glucose; Glutamate Dehydrogenase; Glutamine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoleucine; Leucine; Rats; Stimulation, Chemical	1981
Decreased L-system for amino acid transport in chronic lymphocytic leukemic lymphocytes. The Journal of biological chemistry, 1982, Aug-25, Volume: 257, Issue:16 Topics: Amino Acids; Amino Acids, Cyclic; B-Lymphocytes; Biological Transport; Cell Line; Humans; Kinetics; Leucine; Leukemia, Lymphoid; T-Lymphocytes	1982
Changes of function and metabolism of the pancreatic B-cell caused by amino acids and related compounds. Hormone and metabolic research. Supplement series, 1980, Volume: Suppl 10 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Caproates; In Vitro Techniques; Insulin; Islets of Langerhans; Keto Acids; Leucine; Mice	1980
Heterogeneity of Na+-independent 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid and L-leucine transport in isolated rat hepatocytes in primary culture. Biochemical and biophysical research communications, 1982, Jan-15, Volume: 104, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport; Cells, Cultured; Kinetics; Leucine; Liver; Rats; Sodium	1982
Characterization of neutral amino acid uptake by cultured epithelial cells from pig kidney. Journal of cellular physiology, 1982, Volume: 112, Issue:2 Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport; Cell Line; Epithelium; Kidney; Kidney Tubules, Proximal; Kinetics; Leucine; Sodium; Swine	1982
Hexose metabolism in pancreatic islets: regulation of the mitochondrial NADH/NAD+ ratio. Biochemical and molecular medicine, 1995, Volume: 55, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Aminooxyacetic Acid; Animals; Calcium; Glucose; In Vitro Techniques; Islets of Langerhans; Keto Acids; Leucine; Mitochondria; NAD; Oxidation-Reduction; Phenylpyruvic Acids; Quaternary Ammonium Compounds; Rats; Rats, Wistar	1995
Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrier. The Journal of biological chemistry, 1995, Jun-23, Volume: 270, Issue:25 Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Blood-Brain Barrier; Cattle; Cell Fractionation; Cell Membrane; Centrifugation, Zonal; Endothelium, Vascular; Ficoll; Glutamine; Kinetics; Leucine; Microcirculation; Phenylalanine; Sodium; Tryptophan	1995
Heterogeneous secretion of individual B cells in response to D-glucose and to nonglucidic nutrient secretagogues. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1 Topics: Amino Acids; Amino Acids, Cyclic; Animals; DNA-Binding Proteins; Early Growth Response Protein 1; Glucokinase; Glucose; Glucose Transporter Type 2; Glutamates; Hemolytic Plaque Technique; Immediate-Early Proteins; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Monosaccharide Transport Proteins; Rats; Rats, Sprague-Dawley; Succinates; Transcription Factors	1995
Characteristics of alpha-aminoisobutyric acid transport by lactating rat mammary gland. The Journal of dairy research, 1994, Volume: 61, Issue:1 Topics: Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Animals; beta-Alanine; Biological Transport; Female; Kinetics; Lactation; Leucine; Mammary Glands, Animal; Phenylalanine; Rats; Rats, Wistar; Sodium; Tryptophan	1994
Alanine and leucine transport in unfertilized pig oocytes and early blastocysts. Molecular reproduction and development, 1993, Volume: 34, Issue:3 Topics: Alanine; Amino Acids; Amino Acids, Cyclic; Animals; Biological Transport, Active; Blastocyst; Cell Membrane; Female; In Vitro Techniques; Kinetics; Leucine; Oocytes; Pregnancy; Sodium; Swine	1993
The regulation of L-proline transport by insulin-like growth factor-I in human osteoblast-like SaOS-2 cells. Pflugers Archiv : European journal of physiology, 1996, Volume: 432, Issue:3 Topics: Amino Acids; Amino Acids, Cyclic; beta-Alanine; Biological Transport, Active; Cell Line; Cycloheximide; Humans; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor I; Kinetics; Leucine; Osteoblasts; Proline; Protein Synthesis Inhibitors	1996
Glucose regulation of glutaminolysis and its role in insulin secretion. Diabetes, 1999, Volume: 48, Issue:8 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Calcium; Culture Techniques; Cytosol; Dose-Response Relationship, Drug; Glucose; Glutamine; Glycolysis; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Mice; Oxidation-Reduction; Rats	1999
Antiallodynic effect of intrathecal gabapentin and its interaction with clonidine in a rat model of postoperative pain. Anesthesiology, 2000, Volume: 92, Issue:4 Topics: Acetates; Adrenergic alpha-Agonists; Amines; Amino Acids; Amino Acids, Cyclic; Analgesics; Animals; Behavior, Animal; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Injections, Spinal; Leucine; Male; Pain Threshold; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Reflex	2000
Characterization of 3-[(123)I]iodo-L-alpha-methyl tyrosine transport in astrocytes of neonatal rats. Journal of neurochemistry, 2001, Volume: 76, Issue:1 Topics: alpha-Methyltyrosine; Amino Acid Transport Systems; Amino Acids, Cyclic; Animals; Animals, Newborn; Astrocytes; beta-Alanine; Binding, Competitive; Biological Transport; Carrier Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Glioma; Leucine; Methyltyrosines; Phenylalanine; Radiopharmaceuticals; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2001
Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes, 2001, Volume: 50, Issue:2 Topics: Allosteric Regulation; Amino Acids, Cyclic; Cell Line; Decarboxylation; Enzyme Activation; Glutamate Dehydrogenase; Glutamic Acid; Islets of Langerhans; Isoleucine; Leucine; Mitochondria; Models, Biological; Oxidation-Reduction; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Biosynthesis; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Valine	2001
Large neutral amino acids auto exchange when infused by microdialysis into the rat brain: implication for maple syrup urine disease and phenylketonuria. Neurochemistry international, 2002, Volume: 40, Issue:4 Topics: Amino Acid Transport Systems, Neutral; Amino Acids, Cyclic; Amino Acids, Neutral; Animals; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Extracellular Space; Hippocampus; Keto Acids; Leucine; Maple Syrup Urine Disease; Microdialysis; Models, Biological; Nerve Tissue Proteins; Neurons; Phenylalanine; Phenylketonurias; Rats; Tyrosine	2002
Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochimica et biophysica acta, 2002, Sep-20, Volume: 1565, Issue:1 Topics: Amino Acids, Cyclic; Biological Transport; Blotting, Northern; Carbon Radioisotopes; Cell Membrane; Endocytosis; Fluorescent Antibody Technique; Fusion Regulatory Protein 1, Heavy Chain; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Urinary Bladder Neoplasms	2002
Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells. European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2 Topics: Alanine; Amino Acid Transport Systems; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Calcium; Cysteine; Dose-Response Relationship, Drug; Leucine; Nitric Oxide Donors; PC12 Cells; Phenylalanine; Rats; RNA, Messenger; S-Nitrosothiols; Stereoisomerism; Tritium	2003
Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 285, Issue:2 Topics: Adenosine Triphosphate; Amino Acids, Cyclic; Animals; Citric Acid; Citric Acid Cycle; Diazoxide; Enzyme Activation; Esterification; Glucose; Glutamate Dehydrogenase; Glutamine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Lipid Metabolism; Male; Oxidation-Reduction; Palmitic Acid; Potassium Channels; Potassium Chloride; Rats; Rats, Sprague-Dawley; Signal Transduction	2003
Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. The Journal of biological chemistry, 2004, Feb-27, Volume: 279, Issue:9 Topics: Amino Acids; Amino Acids, Cyclic; Animals; Bacterial Toxins; Cell Membrane; Enzyme Inhibitors; Hemolysin Proteins; Hepatocytes; Insulin; Leucine; Male; Peptide Hydrolases; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2004
Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets. Diabetologia, 2004, Volume: 47, Issue:2 Topics: Adenosine Triphosphate; Amino Acids; Amino Acids, Cyclic; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Glucose; Glutamate Dehydrogenase; Glutamine; Humans; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Membrane Potentials; Mice; Mice, Inbred BALB C; Mitochondria; Oxidation-Reduction; Potassium Chloride; Rats; Rats, Wistar	2004
Expression and functional characterization of the system L amino acid transporter in KB human oral epidermoid carcinoma cells. Cancer letters, 2004, Mar-18, Volume: 205, Issue:2 Topics: Amino Acid Transport System y+; Amino Acids, Cyclic; Fusion Regulatory Protein 1, Light Chains; Humans; Immunohistochemistry; KB Cells; Large Neutral Amino Acid-Transporter 1; Leucine	2004
System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells. Neuroscience research, 2004, Volume: 50, Issue:4 Topics: Amino Acid Transport System y+; Amino Acids, Cyclic; Amino Acids, Neutral; Animals; Animals, Newborn; Astrocytes; Biological Transport, Active; Brain; Brain Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cells, Cultured; Fusion Regulatory Protein 1, Heavy Chain; Fusion Regulatory Protein 1, Light Chains; Glioma; Large Neutral Amino Acid-Transporter 1; Leucine; Rats; Rats, Wistar	2004
Large neutral amino acid transporter enables brain drug delivery via prodrugs. Journal of medicinal chemistry, 2008, Feb-28, Volume: 51, Issue:4 Topics: Amino Acids, Cyclic; Animals; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Drug Delivery Systems; Endothelial Cells; Feasibility Studies; Ketoprofen; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Perfusion; Prodrugs; Rats; Rats, Wistar; Tyrosine	2008
Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. Neurosurgery, 2008, Volume: 62, Issue:2 Topics: Amino Acids, Cyclic; Animals; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Fusion Regulatory Protein 1, Heavy Chain; Glioma; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Leucine; Mice; Mice, Nude; Neoplasms, Experimental; Reverse Transcriptase Polymerase Chain Reaction	2008
BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:6 Topics: Actins; Amino Acid Transport Systems; Amino Acids, Cyclic; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Division; Cell Line, Tumor; DNA Fragmentation; Enzyme Activation; Humans; In Situ Nick-End Labeling; KB Cells; Large Neutral Amino Acid-Transporter 1; Leucine; Tetrazolium Salts; Thiazoles	2008
A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochemical and biophysical research communications, 2008, Nov-14, Volume: 376, Issue:2 Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems, Neutral; Amino Acids, Cyclic; Animals; Blood-Brain Barrier; Carnitine; Cattle; Leucine; Rats	2008
Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells. Oncology reports, 2008, Volume: 20, Issue:4 Topics: Amino Acid Transport System L; Amino Acids, Cyclic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Fusion Regulatory Protein 1, Heavy Chain; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Melphalan	2008
System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. Cancer letters, 2009, Apr-08, Volume: 276, Issue:1 Topics: Amino Acids, Cyclic; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Drug Synergism; Fusion Regulatory Protein 1, Heavy Chain; Head and Neck Neoplasms; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Protein Kinases; TOR Serine-Threonine Kinases	2009
Properties of L-type amino acid transporter 1 in epidermal ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2010, Volume: 20, Issue:3 Topics: Amino Acids, Cyclic; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Large Neutral Amino Acid-Transporter 1; Leucine; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Ovary; Peptide Fragments; Tumor Cells, Cultured	2010
LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing. Molecular and cellular biochemistry, 2011, Volume: 349, Issue:1-2 Topics: Adaptor Proteins, Signal Transducing; Alanine; Amino Acid Transport System ASC; Amino Acids, Cyclic; Animals; Cell Line; Cell Proliferation; Cellular Senescence; Down-Regulation; Fusion Regulatory Protein 1, Heavy Chain; Kidney Tubules, Proximal; Kinetics; Large Neutral Amino Acid-Transporter 1; Leucine; Opossums; Polyploidy; Subcellular Fractions	2011
Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. Anticancer research, 2010, Volume: 30, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Cyclic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Growth Processes; Cell Line, Tumor; ErbB Receptors; Fusion Regulatory Protein-1; Gefitinib; Humans; Immunohistochemistry; Large Neutral Amino Acid-Transporter 1; Leucine; Lung Neoplasms; Middle Aged; Mutation; Quinazolines; RNA, Messenger; TOR Serine-Threonine Kinases	2010
Amino acid transport system L activity in developing mouse ovarian follicles. Human reproduction (Oxford, England), 2011, Volume: 26, Issue:11 Topics: Amino Acid Transport System L; Amino Acids, Cyclic; Animals; Biological Transport; Corpus Luteum; Female; Fertility; Gene Expression Regulation, Developmental; Granulosa Cells; Insulin-Like Growth Factor I; Leucine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovarian Follicle	2011
L-Leucine induces growth arrest and persistent ERK activation in glioma cells. Amino acids, 2012, Volume: 43, Issue:2 Topics: Amino Acids, Cyclic; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Cyclin D1; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; JNK Mitogen-Activated Protein Kinases; Large Neutral Amino Acid-Transporter 1; Leucine; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Rats	2012
Transpulmonary flux of S-nitrosothiols and pulmonary vasodilation during nitric oxide inhalation: role of transport. American journal of respiratory cell and molecular biology, 2012, Volume: 47, Issue:1 Topics: Administration, Inhalation; Amino Acids, Cyclic; Animals; Biological Transport, Active; Cysteine; Female; Hypertension, Pulmonary; Leucine; Lung; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; S-Nitrosothiols; Vasodilation	2012
Targeting glutamine transport to suppress melanoma cell growth. International journal of cancer, 2014, Sep-01, Volume: 135, Issue:5 Topics: Amino Acid Transport System ASC; Amino Acids, Cyclic; Benzyl Compounds; Biological Transport; Carrier Proteins; CDC2 Protein Kinase; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Glutamine; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mechanistic Target of Rapamycin Complex 1; Melanoma; Minor Histocompatibility Antigens; Multiprotein Complexes; Proto-Oncogene Proteins B-raf; RNA Interference; RNA, Small Interfering; Serine; Signal Transduction; Skin Neoplasms; Spheroids, Cellular; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Ubiquitin-Conjugating Enzymes	2014
Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration. Cellular signalling, 2014, Volume: 26, Issue:8 Topics: Amino Acids, Cyclic; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Down-Regulation; Fusion Regulatory Protein 1, Heavy Chain; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Isoforms; RNA, Messenger; Tumor Cells, Cultured	2014
Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter. Bioscience, biotechnology, and biochemistry, 2015, Volume: 79, Issue:12 Topics: Amino Acid Transport System L; Amino Acids; Amino Acids, Cyclic; Animals; Dose-Response Relationship, Drug; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Sirolimus; Time Factors; TOR Serine-Threonine Kinases	2015
Positive Regulation of Decidualization by l-Type Amino Acid Transporter 1 (lat1) in Pregnant Mice. Nutrients, 2016, Nov-05, Volume: 8, Issue:11 Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Amino Acids, Cyclic; Animals; Biological Transport; Cells, Cultured; Decidua; Down-Regulation; Embryo Implantation; Embryonic Development; Female; Gene Expression; Gestational Age; Leucine; Mice; Pregnancy; RNA, Messenger; RNA, Small Interfering; Stromal Cells; Uterus	2016
Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. Thrombosis and haemostasis, 2017, 06-28, Volume: 117, Issue:7 Topics: Amino Acid Transport System L; Amino Acids, Cyclic; Animals; Benzoxazoles; Cell Adhesion; Cysteine; Endothelial Cells; Erythrocyte Deformability; Erythrocytes; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Leucine; Mice; Mice, Nude; Reticulocytes; RNA, Messenger; S-Nitrosothiols; Tyrosine	2017
Fibroblast-like synoviocyte migration is enhanced by IL-17-mediated overexpression of L-type amino acid transporter 1 (LAT1) via the mTOR/4E-BP1 pathway. Amino acids, 2018, Volume: 50, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Amino Acids, Cyclic; Arthritis, Rheumatoid; Cell Cycle Proteins; Cell Movement; Cells, Cultured; Female; Fibroblasts; Gene Expression; Gene Expression Regulation; Humans; Leucine; Middle Aged; Phosphoproteins; RNA, Small Interfering; Signal Transduction; Sirolimus; Synovial Membrane; Synoviocytes; TOR Serine-Threonine Kinases	2018
Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis. Apoptosis : an international journal on programmed cell death, 2020, Volume: 25, Issue:5-6 Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoxazoles; Brain; Brain Chemistry; Carboxylic Acids; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Injections, Intraperitoneal; Large Neutral Amino Acid-Transporter 1; Leucine; Male; MCF-7 Cells; Mice; Myocytes, Smooth Muscle; NF-kappa B; Norbornanes; Primary Cell Culture; Pyridines; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tyrosine	2020