2-aminoadipic acid and methotrexate

2-aminoadipic acid has been researched along with methotrexate in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (53.85)	18.2507
2000's	6 (46.15)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Mihara, M; Moriya, Y; Takagi, N; Takeda, Y; Urakawa, K	3
Kaneko, E; Mihara, M; Suzuki, T; Takagi, N; Takeda, Y	1
Hiraoka, M; Mihara, M; Miyasaka, N; Takeda, Y	1
Han, YH; Kato, Y; Sugiyama, Y	2
Akamatsu, K; Kamatani, N; Kawamura, A; Mihara, M; Suzuki, T; Takeda, Y; Urakawa, K	1
Asoh, Y; Han, YH; Kato, Y; Sugiyama, Y; Terao, K; Watanabe, Y	1
Akamatsu, K; Kawamura, A; Mihara, M; Takagi, N; Takeda, Y; Urakawa, K	1
Chen, JF; Cronstein, BN; Delano, D; Desai, A; Fink, JS; Jacobson, MA; Montesinos, MC	1
Akabane, H; Komai, M; Masuda, T; Nagai, H; Nagao, K; Tanaka, H	1
Asakura, M; Asanuma, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Ogai, A; Ogita, H; Sanada, S; Shinozaki, Y; Takashima, S; Tomoike, H	1

Trials

1 trial(s) available for 2-aminoadipic acid and methotrexate

Article	Year
A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice. International archives of allergy and immunology, 1997, Volume: 113, Issue:4 Topics: 2-Aminoadipic Acid; Administration, Oral; Animals; Antigen-Antibody Complex; Autoantibodies; Autoimmune Diseases; Blood Urea Nitrogen; Cell Division; Cholesterol; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Kidney Diseases; Lupus Nephritis; Lymph Nodes; Methotrexate; Mice; Mice, Inbred MRL lpr; Picrates; Proteinuria; Specific Pathogen-Free Organisms; Spleen	1997

Article

Year

A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice.

International archives of allergy and immunology, 1997, Volume: 113, Issue:4

Topics: 2-Aminoadipic Acid; Administration, Oral; Animals; Antigen-Antibody Complex; Autoantibodies; Autoimmune Diseases; Blood Urea Nitrogen; Cell Division; Cholesterol; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Kidney Diseases; Lupus Nephritis; Lymph Nodes; Methotrexate; Mice; Mice, Inbred MRL lpr; Picrates; Proteinuria; Specific Pathogen-Free Organisms; Spleen

1997

Other Studies

12 other study(ies) available for 2-aminoadipic acid and methotrexate

Article	Year
In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68. Immunopharmacology, 1996, Volume: 35, Issue:1 Topics: 2-Aminoadipic Acid; Animals; Arthritis, Experimental; Cell Division; Cells, Cultured; Collagen; Endothelium, Vascular; Fibroblasts; Folic Acid Antagonists; Humans; Leukocytes, Mononuclear; Methotrexate; Mice; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase	1996
Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE). International journal of immunopharmacology, 1997, Volume: 19, Issue:2 Topics: 2-Aminoadipic Acid; Age Factors; Animals; Autoantibodies; Blood Urea Nitrogen; Cholesterol; Chronic Disease; Disease Models, Animal; Female; Folic Acid Antagonists; Graft vs Host Disease; Lupus Erythematosus, Systemic; Lupus Nephritis; Methotrexate; Mice; Mice, Inbred DBA; Mice, Inbred NZB; Proteinuria	1997
Immunosuppressive properties of MX-68, a novel unpolyglutamatable antifolate. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:10 Topics: 2-Aminoadipic Acid; Animals; Cells, Cultured; Female; Folic Acid Antagonists; Hypersensitivity, Delayed; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Lymphocyte Activation; Lymphocytes; Methotrexate; Mice; Mice, Inbred BALB C; Spleen	1997
A novel non-polyglutamable anti-folate, MX-68, inhibits the induction of experimental autoimmune uveitis in rats. Experimental eye research, 1998, Volume: 67, Issue:1 Topics: 2-Aminoadipic Acid; Animals; Arrestin; Arthritis, Experimental; Autoimmune Diseases; Cell Division; Cells, Cultured; Collagen; Concanavalin A; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Immunization; Immunosuppressive Agents; Lymphocytes; Methotrexate; Rats; Rats, Inbred Strains; Uveitis	1998
Nonlinear disposition kinetics of a novel antifolate, MX-68, in rats. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1 Topics: 2-Aminoadipic Acid; Administration, Oral; Animals; Anion Transport Proteins; Binding Sites; Carrier Proteins; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Folic Acid Antagonists; Ion Transport; Kidney Cortex; Liver; Male; Metabolic Clearance Rate; Methotrexate; Microvilli; Rats; Rats, Sprague-Dawley; Tissue Distribution	1999
Binding and transport of methotrexate and its derivative, MX-68, across the brush-border membrane in rat kidney. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:8 Topics: 2-Aminoadipic Acid; Animals; Biological Transport; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kidney; Male; Methotrexate; Microvilli; Osmolar Concentration; Rats; Rats, Sprague-Dawley	1999
Polyglutamation of antifolates is not required for induction of extracellular release of adenosine or expression of their anti-inflammatory effects. Immunopharmacology, 2000, Jul-20, Volume: 48, Issue:2 Topics: 2-Aminoadipic Acid; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cell Line; Extracellular Space; Female; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Inbred BALB C; Pteroylpolyglutamic Acids	2000
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:4 Pt 1 Topics: 2-Aminoadipic Acid; Animals; Anion Transport Proteins; Anions; Antimetabolites; Biological Transport; Carrier Proteins; Cells, Cultured; Drug Carriers; Folic Acid; Folic Acid Antagonists; Glutathione; Hepatocytes; Hydrogen-Ion Concentration; Male; Methotrexate; Rats; Sodium; Time Factors; Transport Vesicles; Tritium	2001
Polyglutamation of a novel antifolate, MX-68, is not necessary for its anti-arthritic effect. European journal of pharmacology, 2002, Jan-25, Volume: 435, Issue:2-3 Topics: 2-Aminoadipic Acid; Animals; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Experimental; Cell Division; Cells, Cultured; Disease Models, Animal; Folic Acid Antagonists; Male; Methotrexate; Mice; Mice, Inbred DBA; Peptide Synthases; Polyglutamic Acid; Rats; Rats, Inbred Lew; Substrate Specificity; Tetrahydrofolate Dehydrogenase	2002
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis and rheumatism, 2003, Volume: 48, Issue:1 Topics: 2-Aminoadipic Acid; Acute Disease; Animals; Antirheumatic Agents; Arthritis; Methotrexate; Mice; Mice, Knockout; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha	2003
Effect of MX-68 on airway inflammation and hyperresponsiveness in mice and guinea-pigs. The Journal of pharmacy and pharmacology, 2004, Volume: 56, Issue:2 Topics: 2-Aminoadipic Acid; Acetylcholine; Administration, Inhalation; Allergens; Animals; Body Weight; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Immunoglobulins; Injections, Intraperitoneal; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Methotrexate; Mice; Mice, Inbred BALB C; Ovalbumin; Prednisolone	2004
Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts. Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:4 Topics: 2-Aminoadipic Acid; Adenosine; Animals; Cardiotonic Agents; Dogs; Methotrexate; Myocardial Infarction; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline	2004