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2-aminoadamantane and amantadine

2-aminoadamantane has been researched along with amantadine in 8 studies

*Amantadine: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [MeSH]

*Amantadine: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. [MeSH]

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eleftheratos, S; Hay, A; Kolocouris, A; Martin, S; Martinelli, A; Ortore, G; Spearpoint, P1
Busath, DD; Cross, TA; Fedida, D; Johnson, FB; Kolocouris, A; Tietjen, I; Tzitzoglaki, C; Wright, AK; Zell, R1
Cross, TA; Fedida, D; Freudenberger, K; Gauglitz, G; Hoffmann, A; Kolarov, F; Kolocouris, A; Schmidtke, M; Stylianakis, I; Tietjen, I; Tzitzoglaki, C; Wright, A1
Krapivin, SV; Morozov, IS; Sergeeva, SA1
Chen, YC; Chen, YW; Chu, CC; Hung, CH; Wang, JJ1
Battilocchio, C; Fitzpatrick, DE; Hawkins, JM; Ingham, RJ; Ley, SV; Sliwinski, E1
Avgustinovich, DF; Fomina, MK; Salakhutdinov, NF; Suslov, EV; Tolstikova, TG; Volcho, KP1
Karothu, DP; Mohamed, S; Naumov, P1

Other Studies

8 other study(ies) available for 2-aminoadamantane and amantadine

ArticleYear
Interaction of aminoadamantane derivatives with the influenza A virus M2 channel-docking using a pore blocking model.
    Bioorganic & medicinal chemistry letters, 2010, Jul-15, Volume: 20, Issue:14

    Topics: Adamantane; Amino Acid Sequence; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Viral Matrix Proteins

2010
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.
    Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11

    Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Dogs; Drug Resistance, Multiple, Viral; HEK293 Cells; Humans; Influenza A Virus, H1N1 Subtype; Ion Channels; Madin Darby Canine Kidney Cells; Mutation; Rimantadine; Viral Matrix Proteins

2014
Binding and Proton Blockage by Amantadine Variants of the Influenza M2
    Journal of medicinal chemistry, 2017, 03-09, Volume: 60, Issue:5

    Topics: Amantadine; Antiviral Agents; Influenza A virus; Ligands; Protons; Spectrum Analysis; Viral Matrix Proteins

2017
[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:11

    Topics: Amantadine; Animals; Brain; Electroencephalography; Fourier Analysis; Male; Psychotropic Drugs; Rats; Signal Processing, Computer-Assisted; Time Factors

1993
Rimantadine and 2-adamantanamine elicit local anesthesia to cutaneous nociceptive stimuli in a rat model.
    Fundamental & clinical pharmacology, 2014, Volume: 28, Issue:2

    Topics: Amantadine; Anesthesia, Local; Anesthetics, Local; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Molecular Structure; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Rimantadine; Skin

2014
A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.
    Angewandte Chemie (International ed. in English), 2015, Jan-02, Volume: 54, Issue:1

    Topics: Amantadine; Carboxylic Acids; Chemistry Techniques, Synthetic; Equipment Design

2015
Effect of 2-aminoadamantane derivatives on behavior of mice in a modified light/dark test.
    Bulletin of experimental biology and medicine, 2014, Volume: 158, Issue:2

    Topics: Amantadine; Analysis of Variance; Animals; Behavior, Animal; Darkness; Exploratory Behavior; Female; Light; Male; Mice; Mice, Inbred C57BL; Motor Activity; Sex Factors

2014
Using crystal structure prediction to rationalize the hydration propensities of substituted adamantane hydrochloride salts.
    Acta crystallographica Section B, Structural science, crystal engineering and materials, 2016, 08-01, Volume: 72, Issue:Pt 4

    Topics: Amantadine; Crystallization; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Salts; Thermodynamics; Water

2016