2-amino-5-phosphonovalerate has been researched along with piperidines in 108 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.85) | 18.7374 |
| 1990's | 25 (23.15) | 18.2507 |
| 2000's | 50 (46.30) | 29.6817 |
| 2010's | 31 (28.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baron, BM; Chi, EM; Harrison, BL; Kehne, JH; McCloskey, TC; Palfreyman, MG; Whitten, JP | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Weiss, S | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Shinozaki, H | 1 |
| Boast, CA; Pastor, G | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Santicioli, P | 1 |
| Gold, PE; Walker, DL | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Baranauskas, G; Nistri, A | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Holahan, MR; Kelley, AE; Smith-Roe, SL | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Aanonsen, L; Hargreaves, KM; Richardson, JD | 1 |
| Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
| Bell, MI; Lee, K; Richardson, PJ | 1 |
| Allgaier, C; Feuerstein, TJ; Illes, P; Müller, D; Scheibler, P | 1 |
| Abdrachmanova, G; Palecek, JI; Vlachová, V; Vyklick, L | 1 |
| Bear, MF; Huganir, RL; Philpot, BD; Quinlan, EM | 1 |
| Deakin, JF; Grimwood, S; Hutson, PH; Slater, P | 1 |
| Ebert, U; Löscher, W; Wlaź, P | 1 |
| Katsuyama, S; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K | 1 |
| DeFazio, RA; Hablitz, JJ | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Kouznetsova, M; Nistri, A | 1 |
| Brickley, SG; Cull-Candy, SG; Farrant, M; Misra, C | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Healy, DJ; Hogg, AJ; Ibrahim, HM; Meador-Woodruff, JH | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
| Kolb, JE; Levine, ES | 1 |
| Meador-Woodruff, JH; Ritter, LM; Unis, AS | 1 |
| Kee, N; Snyder, JS; Wojtowicz, JM | 1 |
| Kazuta, Y; Kohsaka, S; Kudo, Y; Matsuda, A; Mishina, M; Nakajima-Iijima, S; Nakamura, T; Shuto, S; Uchino, S; Watanabe, W | 1 |
| Cunningham, MO; Evans, DI; Jones, RS; Woodhall, G | 1 |
| Lu, SM; Yeh, HH; Zecevic, N | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Lei, S; McBain, CJ | 1 |
| Berrino, L; Cuomo, D; de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F | 1 |
| Randich, A; Turnbach, ME | 1 |
| Bakalkin, G; Esashi, A; Kisara, K; Nakagawasai, O; Niijima, F; Sakurada, C; Sakurada, T; Tadano, T; Tan-No, K; Terenius, L | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Minami, M; Nishikawa, H; Satoh, M; Taguchi, R | 1 |
| Dunn, RJ; Harvey-Girard, E | 1 |
| Enz, A; Gemperle, AY; Lüthi, A; Olpe, HR; Pozza, MF | 1 |
| D'Hooge, R; De Deyn, PP; Marescau, B; Van Bogaert, PP; Van de Vijver, G; Vanholder, R | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shibata, H; Takenaka, C | 1 |
| Baimbridge, KG; Fernandes, HB; Krebs, C; Raymond, LA; Sheldon, C | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Auberson, YP; Lingenhoehl, K; Liu, L; Pozza, MF; Sheng, M; Wang, Y; Wang, YT; Wong, TP | 1 |
| Duvoisin, RM; Grandes, P; Kushmerick, C; Price, GD; Puente, N; Renden, R; Taschenberger, H; von Gersdorff, H; Wadiche, JI | 1 |
| Kosowski, AR; Liljequist, S | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Baviera, M; Calcagno, E; Carli, M; Ceglia, I; Invernizzi, RW; Renoldi, G | 1 |
| Boyce-Rustay, JM; Holmes, A | 1 |
| Kiyosue, K; Nakayama, K; Taguchi, T | 1 |
| Clements, JM; Vanhoose, AM; Winder, DG | 1 |
| Baudry, M; Zhou, M | 1 |
| Ivanov, VB; Schilström, B; Svensson, TH; Wiker, C | 1 |
| Cao, J; Dong, ZF; Luo, JH; Tian, M; Xu, L; Zhong, WX | 1 |
| Auberson, YP; Izumi, Y; Zorumski, CF | 1 |
| Manahan-Vaughan, D; Pöschel, B | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Birgner, C; Elfverson, M; Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F | 1 |
| Ge, S; Hsu, KS; Ming, GL; Song, H; Yang, CH | 1 |
| Maeda, H; Ohno, T; Sakurai, M | 1 |
| Araque, A; Navarrete, M | 1 |
| Chang, HM; Chen, GD; Chiu, CH; Huang, PC; Lai, CH; Lai, CY; Lee, SD; Lin, TB; Peng, HY; Tung, KC | 1 |
| Di, S; Franco, A; Maxson, MM; Tasker, JG | 1 |
| Jean, A; Lebrun, B; Roux, J; Trouslard, J; Wanaverbecq, N | 1 |
| Kovacs, FE; Szabo, B; Urbanski, MJ | 1 |
| Carobrez, AP; Kincheski, GC | 1 |
| Magloire, V; Streit, J | 1 |
| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Acuna-Goycolea, C; Obrietan, K; van den Pol, AN | 1 |
| Bevins, RA; Murray, JE; Polewan, RJ; Walker, AW | 1 |
| Doengi, M; Gaburro, S; Häring, M; Kamprath, K; Lutz, B; Pape, HC; Romo-Parra, H | 1 |
| Gu, Y; Huang, S; Kirkwood, A; Quinlan, EM | 1 |
| Chan, MH; Chen, HH; Liao, PF | 1 |
| Alberdi, E; Martín-Satué, M; Matute, C; Solsona, C; Texidó, L | 1 |
| Li, YH; Wang, J; Zhang, G | 1 |
| Adermark, L | 1 |
| Chavis, P; Farrugia, F; Garenne, A; Le Masson, G; Manzoni, OJ; Marsicano, G; Piet, R | 1 |
| Aceves, JJ; Bargas, J; Galarraga, E; Hernandez-Martinez, R; Rueda-Orozco, PE | 1 |
| Chang, SC; Delpire, E; Ghosh, A; Hall, BJ; Held, RG; Wang, CC; Yang, L | 1 |
| Bernardi, G; Berretta, N; Ledonne, A; Mango, D; Mercuri, NB | 1 |
| Min, R; Nevian, T | 1 |
| Li, YH; Wang, J | 1 |
| Bausch, SB; He, S; Shao, LR; Wang, Y | 1 |
| Niere, F; Raab-Graham, KF; Workman, ER | 1 |
| Di Paolo, T; Gasparini, F; Gomez-Mancilla, B; Grégoire, L; Morin, N; Morissette, M | 1 |
| Bonci, A; Chang, SJ; Chen, BT; Dadgar, J; Gibb, SL; Harvey, BK; Hopf, FW; Messing, RO; Ron, D; Seif, T; Simms, JA | 1 |
| Ahumada, J; Buño, W; Couve, A; Fernández de Sevilla, D; Fuenzalida, M | 1 |
| Che, A; Girgenti, MJ; LoTurco, J | 1 |
| Nasehi, M; Oryan, S; Rasekhi, K; Zarrindast, MR | 1 |
| Barksdale, D; Bausch, SB; Dong, Y; Galdzicki, Z; Rittase, WB | 1 |
| Hermann, GE; Rogers, RC; Vance, KM | 1 |
| Bush, K; Dilly, GA; Haddick, PC; Niere, F; Raab-Graham, KF; Workman, ER; Zemelman, BV | 1 |
| Amin-Yavari, S; Ebrahimi-Ghiri, M; Nasehi, M; Torabi-Nami, M; Zarrindast, MR | 1 |
| Jang, HJ; Joo, K; Kim, MJ; Lee, C; Rhie, DJ | 1 |
| Crunelli, V; David, F; Lambert, RC; Leresche, N | 1 |
| Dominic, D; Punnakkal, P | 1 |
1 review(s) available for 2-amino-5-phosphonovalerate and piperidines
| Article | Year |
|---|---|
Pharmacology of the glutamate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Antidepressive Agents; Azepines; Glutamates; Glutamic Acid; Membrane Potentials; Nervous System Diseases; Neurons; Oxazoles; Oxazolidinones; Piperidines; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1988 |
107 other study(ies) available for 2-amino-5-phosphonovalerate and piperidines
| Article | Year |
|---|---|
NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety, Separation; Behavior, Animal; Buspirone; Diazepam; Dioxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Indoles; Kynurenic Acid; Maternal Deprivation; Mephenesin; Piperidines; Quinolizines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin Antagonists; Spiro Compounds; Valine; Vocalization, Animal | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
Pharmacological properties of the N-methyl-D-aspartate receptor system coupled to the evoked release of gamma-[3H] aminobutyric acid from striatal neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Neurons; Pipecolic Acids; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzamides; Cyclophosphamide; Cystitis; Indoles; Injections, Intravenous; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Physalaemin; Piperidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Urinary Incontinence; Urination | 1994 |
Intrahippocampal administration of both the D- and the L-isomers of AP5 disrupt spontaneous alternation behavior and evoked potentials.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroencephalography; Evoked Potentials; Male; Mental Recall; Orientation; Pain Threshold; Piperidines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptic Transmission | 1994 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
NMDA receptor-independent mechanisms responsible for the rate of rise of cumulative depolarization evoked by trains of dorsal root stimuli on rat spinal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Membrane Potentials; Motor Neurons; Neurokinin-1 Receptor Antagonists; Piperazines; Piperidines; Quinuclidines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Nerve Roots | 1996 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Appetitive Behavior; Behavior, Animal; Conditioning, Operant; Dopamine; Excitatory Amino Acid Antagonists; Feeding Behavior; Food Deprivation; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Spinal Cord; Tritium | 1998 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 1998 |
NMDA receptor characterization and subunit expression in rat cultured mesencephalic neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression; Gene Expression Regulation, Developmental; Glycine; Memantine; Mesencephalon; N-Methylaspartate; Neurons; Nitrendipine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Splicing; RNA, Messenger | 1999 |
Properties of NMDA receptors in rat spinal cord motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Magnesium; Male; Motor Neurons; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Animals, Suckling; Bicuculline; Cycloheximide; Darkness; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Light; Male; Models, Neurological; Nerve Tissue Proteins; Neuronal Plasticity; Optic Nerve; Photic Stimulation; Piperidines; Protein Synthesis Inhibitors; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sensory Deprivation; Synapses; Vision, Ocular; Visual Cortex; Zinc | 1999 |
NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Binding Sites; Cadaver; Excitatory Amino Acid Antagonists; Humans; Isomerism; Piperidines; Receptors, N-Methyl-D-Aspartate; Reference Values; Schizophrenia; Temporal Lobe; Up-Regulation | 1999 |
Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kindling, Neurologic; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1999 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1999 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; Humans; In Vitro Techniques; Patch-Clamp Techniques; Piperidines; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
Facilitation of cholinergic transmission by substance P methyl ester in the mouse hippocampal slice preparation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Tetrodotoxin; Valine | 2000 |
Identification of subunits contributing to synaptic and extrasynaptic NMDA receptors in Golgi cells of the rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Ethylenediamines; Evoked Potentials; Excitatory Amino Acid Antagonists; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Macaca nemestrina; Neurons; Organ Specificity; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamic Nuclei; Transcription, Genetic; Tritium | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Brain-derived neurotrophic factor increases activity of NR2B-containing N-methyl-D-aspartate receptors in excised patches from hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Antagonists; Guanosine Triphosphate; Hippocampus; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2000 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation, Developmental; Humans; Indoles; Kainic Acid; Piperidines; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tritium | 2001 |
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cell Division; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Long-Term Potentiation; Male; Neuronal Plasticity; Neurons; Organ Culture Techniques; Picrotoxin; Piperidines; Rats; Rats, Wistar | 2001 |
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Glycine; Hot Temperature; Piperidines; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Valine | 2001 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Piperidines; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 2001 |
Distinct NMDA and AMPA receptor-mediated responses in mouse and human Cajal-Retzius cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Mice; Neurons; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Calcium; Chlorides; Cyclopropanes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Mossy Fibers, Hippocampal; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Polyamines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 2002 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; Pain; Periaqueductal Gray; Phosphoserine; Piperidines; Protein Binding; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptors, Drug; Receptors, Glutamate; Riluzole; Rimonabant; Time Factors | 2002 |
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Zymosan | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclopentanes; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamates; Haloperidol; Neurons; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sodium Azide | 2002 |
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Cells, Cultured; Conserved Sequence; DNA, Complementary; Electric Fish; Electric Organ; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kidney; Molecular Sequence Data; N-Methylaspartate; Piperidines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2003 |
Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Haloperidol; In Vitro Techniques; Isoxazoles; Magnesium; Male; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors | 2003 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channels; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Guanidines; Membrane Potentials; Mice; Neurons; Nickel; Piperidines; Potassium Channel Blockers; Seizures; Spermine; Spinal Cord; Succinates; Synapses; Tetraethylammonium; Tetrodotoxin; Uremia | 2003 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Colforsin; Culture Techniques; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Immunohistochemistry; Magnesium; Mesencephalon; Neurons; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Male; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2004 |
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Evoked Potentials, Auditory, Brain Stem; Glycine; Ion Transport; Morpholines; Naphthalenes; Nerve Endings; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols; Scopolamine; Synaptic Transmission; Xanthenes | 2004 |
The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Drug Synergism; Male; Microdialysis; Motor Activity; Nicotine; Nucleus Accumbens; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Extracellular Space; Fluorobenzenes; Glutamic Acid; Male; Microdialysis; Nicotine; Piperazines; Piperidines; Potassium Chloride; Prefrontal Cortex; Rats; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin | 2004 |
Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Sleep | 2005 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2005 |
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcineurin Inhibitors; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxazoles; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperidines; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Mecamylamine; Microdialysis; Neurons; Nicotinic Antagonists; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Ventral Tegmental Area | 2007 |
N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Blotting, Western; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression; Hippocampus; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Male; Membrane Proteins; Phenols; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Time Factors | 2006 |
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.
Topics: Animals; Chelating Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Organ Culture Techniques; Phenanthrolines; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Zinc | 2006 |
Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anisomycin; Calcium Channel Blockers; Calcium Channels, L-Type; Dentate Gyrus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Emetine; Excitatory Amino Acid Antagonists; Gallopamil; Long-Term Synaptic Depression; Male; Piperidines; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Wakefulness | 2007 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells.
Topics: 2-Amino-5-phosphonovalerate; Cell Adhesion; Cell Line, Tumor; Excitatory Amino Acid Agonists; Glioma; Glutamic Acid; Humans; Hybrid Cells; Neurites; Neuroblastoma; Piperidines; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids | 2007 |
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Critical Period, Psychological; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation; Green Fluorescent Proteins; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 2007 |
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Coculture Techniques; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Pyridinium Compounds; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Spinal Cord; Synapses; Synaptic Transmission; Time Factors | 2007 |
Endocannabinoids mediate neuron-astrocyte communication.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Calcium; Cannabinoid Receptor Modulators; Cell Communication; Egtazic Acid; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Photolysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Type C Phospholipases; Valine | 2008 |
TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Muscle, Smooth; Neurons, Afferent; Pelvic Pain; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; TRPV Cation Channels; Uterus | 2008 |
Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.
Topics: Animals; Arginine; Cannabinoid Receptor Modulators; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Dronabinol; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucocorticoids; Glutamic Acid; GTP-Binding Proteins; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Piperidines; Pyrans; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Valine | 2009 |
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Capsaicin; Efferent Pathways; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Pyridazines; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Tetrodotoxin; Vagus Nerve | 2009 |
Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling.
Topics: Aniline Compounds; Animals; Animals, Newborn; Arachidonic Acids; Benzamides; Bicuculline; Biophysics; Calcium; Calcium Signaling; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Carbamates; Cerebellum; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluoresceins; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lactones; Mice; Muscimol; Orlistat; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Quinoxalines; Rimonabant; Signal Transduction; Synapses; Valine | 2009 |
The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze.
Topics: Analysis of Variance; Animals; Avoidance Learning; Catheters, Indwelling; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fear; Injections, Intraventricular; Male; Maze Learning; Periaqueductal Gray; Piperidines; Rats; Rats, Wistar; Space Perception; Staining and Labeling; Valine | 2010 |
Intrinsic activity and positive feedback in motor circuits in organotypic spinal cord slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Atropine; Carbenoxolone; Choline O-Acetyltransferase; Coculture Techniques; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Feedback, Physiological; Heptanoic Acids; Motor Neurons; Muscarinic Antagonists; Muscle, Skeletal; Nerve Net; Neurofilament Proteins; Nicotinic Antagonists; Patch-Clamp Techniques; Piperidines; Rats; Rats, Wistar; Spinal Cord; Statistics, Nonparametric; Synaptic Transmission; Tissue Culture Techniques; Tubocurarine | 2009 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
Cannabinoids excite circadian clock neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adaptation, Ocular; Analgesics; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Benzoxazines; Biophysics; Cannabinoids; Circadian Rhythm; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Transgenic; Morpholines; Motor Activity; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Suprachiasmatic Nucleus; Tetrodotoxin; Valine | 2010 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala.
Topics: Action Potentials; Adaptation, Psychological; Amygdala; Animals; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Psychological; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; GABA Antagonists; Gene Expression Regulation; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphinic Acids; Piperidines; Propanolamines; Pyrazoles; Pyridazines; Quinoxalines; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; Signal Transduction; Time Factors; Valine | 2011 |
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoxazines; Biophysics; Calcium Channel Blockers; Darkness; Dominance, Ocular; Electric Stimulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Refractory Period, Electrophysiological; Sensory Deprivation; Synaptic Transmission; Time Factors; Visual Cortex | 2010 |
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Ketamine; Male; Mice; Mice, Nude; Piperidines; Protein Kinase C; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2011 |
Amyloid β peptide oligomers directly activate NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiological Phenomena; Female; Humans; Memantine; Neurons; Oocytes; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Xenopus laevis | 2011 |
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Long-Term Synaptic Depression; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Potentials; Visual Cortex; Zinc | 2011 |
Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons.
Topics: Animals; Animals, Newborn; Benzazepines; Bicuculline; Biophysics; Cannabinoid Receptor Modulators; Cholinergic Agents; Chromones; Corpus Striatum; Dopamine Antagonists; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Interneurons; Long-Term Potentiation; Models, Neurological; Neural Inhibition; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Sulpiride; Valine | 2011 |
State-dependent, bidirectional modulation of neural network activity by endocannabinoids.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Benzothiadiazines; Brain; Cannabinoid Receptor Modulators; Cells, Cultured; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Mice; Mice, Transgenic; Nerve Net; Neural Inhibition; Neurons; Organophosphorus Compounds; Picrotoxin; Piperidines; Potassium Channel Blockers; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sodium Channel Blockers; Tetrodotoxin; Valine | 2011 |
Bidirectional plasticity in striatonigral synapses: a switch to balance direct and indirect basal ganglia pathways.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Basal Ganglia; Benzazepines; Benzoxazines; Biophysics; Cannabinoids; Chelating Agents; Corpus Striatum; Dopamine Agonists; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Synaptic Depression; Male; Morpholines; Naphthalenes; Neural Pathways; Piperidines; Pyrazoles; Rats; Substantia Nigra; Synapses; Synaptic Transmission; Time Factors; Valine | 2011 |
A critical role for GluN2B-containing NMDA receptors in cortical development and function.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Immunosuppressive Agents; Mice; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Sirolimus; Social Behavior; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Valine | 2011 |
Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neural Pathways; Patch-Clamp Techniques; Phenols; Piperidines; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2012 |
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Astrocytes; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Morpholines; Naphthalenes; Neocortex; Patch-Clamp Techniques; Piperidines; Probability; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Thalamus; Time Factors | 2012 |
Membrane insertion of new AMPA receptors and LTP induced by glycine is prevented by blocking NR2A-containing NMDA receptors in the rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2013 |
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Miniature Postsynaptic Potentials; Neuronal Plasticity; Neurons; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 1 | 2013 |
mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baclofen; Brain-Derived Neurotrophic Factor; Calcium; Calcium Channels, L-Type; Cells, Cultured; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-B Receptor Agonists; Hippocampus; Humans; Immobility Response, Tonic; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Nerve Tissue Proteins; Organophosphorus Compounds; Piperidines; Prefrontal Cortex; Primary Cell Culture; Receptors, AMPA; Receptors, GABA-B; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Imidazoles; Levodopa; Macaca fascicularis; Oximes; Parkinsonian Disorders; Phenols; Piperidines; Pyridines; Quinazolines; Radioligand Assay; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tritium; Xanthenes | 2013 |
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.
Topics: Alcohol Deterrents; Alcohol Drinking; Amygdala; Animals; Avoidance Learning; Bacterial Proteins; Cerebral Cortex; Conditioning, Operant; Drug Resistance; Ethanol; Excitatory Amino Acid Antagonists; Halorhodopsins; Luminescent Proteins; Male; Nerve Tissue Proteins; Nucleus Accumbens; Optogenetics; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Quinine; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA Interference; RNA, Small Interfering; Valine | 2013 |
Long-term depression of inhibitory synaptic transmission induced by spike-timing dependent plasticity requires coactivation of endocannabinoid and muscarinic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cholinergic Agents; Endocannabinoids; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Synaptic Transmission; Valine | 2013 |
The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Dyslexia; Excitatory Amino Acid Antagonists; Gene Expression; Membrane Potentials; Mice; Mice, Knockout; Microelectrodes; Microtubule-Associated Proteins; Neocortex; Patch-Clamp Techniques; Phenols; Piperidines; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, RNA; Tissue Culture Techniques | 2014 |
Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Memory Disorders; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2014 |
Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dynorphins; Memantine; Mossy Fibers, Hippocampal; Neuropeptide Y; Phenols; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Up-Regulation | 2014 |
NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Afferent Pathways; Animals; Aspartic Acid; Benzimidazoles; Calcium; Excitatory Amino Acid Antagonists; In Vitro Techniques; Piperidines; Pregnenolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Sulfonamides; Vagus Nerve | 2015 |
Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η.
Topics: 14-3-3 Proteins; Animals; Animals, Newborn; Antidepressive Agents; Cells, Cultured; Disease Models, Animal; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Immunoprecipitation; Male; Mice; Neurons; Phenols; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger; Stress, Psychological; Swimming; Synaptosomes; Transduction, Genetic; Valine | 2015 |
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Learning; CA1 Region, Hippocampal; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Exploratory Behavior; Male; Mice; Microinjections; N-Methylaspartate; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate | 2015 |
GluN2B-containing N-methyl-D-aspartate receptors compensate for the inhibitory control of synaptic plasticity during the early critical period in the rat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Bicuculline; Diazepam; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression Regulation, Developmental; Long-Term Potentiation; Male; Neural Inhibition; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Visual Cortex | 2015 |
Dynamic Analysis of the Conditional Oscillator Underlying Slow Waves in Thalamocortical Neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzamides; Calcium; Calcium Channel Blockers; Cats; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Geniculate Bodies; In Vitro Techniques; Membrane Potentials; Models, Neurological; Neurons; Nonlinear Dynamics; Organophosphorus Compounds; Patch-Clamp Techniques; Piperidines; Pyridazines | 2016 |
NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Antagonists; Female; Male; Organ Specificity; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sulfonamides | 2018 |