2-amino-5-phosphonovalerate has been researched along with phencyclidine in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (32.84) | 18.7374 |
| 1990's | 37 (55.22) | 18.2507 |
| 2000's | 7 (10.45) | 29.6817 |
| 2010's | 1 (1.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anis, NA; Bukownik, R; Eldefrawi, AT; Eldefrawi, ME; Goodnow, RA; Nakanishi, K; Usherwood, PN | 1 |
| Sage, GP; Sethy, VH | 1 |
| Chapman, CD; Howard, S; Marek, P | 1 |
| Holopainen, I; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Bonhaus, DW; McNamara, JO | 1 |
| Hönack, D; Löscher, W | 1 |
| Borsini, F; Gragnani, L; Lecci, A; Meli, A; Volterra, G | 1 |
| Angst, C; Brundish, DE; Fagg, G; Hurt, SD; Pozza, M; Sills, MA; Williams, M; Wilusz, EJ | 1 |
| Nishikawa, T; Ohi, K; Takahashi, K; Takashima, M | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A | 1 |
| Chai, CY; Kao, MC; Lee, HK; Wang, Y | 1 |
| Lipton, P; Lobner, D | 1 |
| Ohno, Y; Warnick, JE | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Aanonsen, LM; Lei, S; Wilcox, GL | 1 |
| Cannon-Spoor, HE; Freed, WJ | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Dingledine, R; McNamara, D | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Jope, RS; Li, X; Ormandy, GC | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Arnolde, SM; Nevins, ME | 1 |
| Benedetti, M; Pézzola, A; Sagratella, S; Scotti de Carolis, A | 1 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| MacDonald, JF; Schneiderman, JH | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Kleer, E; Koek, W; Mudar, PJ; Woods, JH | 1 |
| Koek, W; Ornstein, P; Woods, JH | 2 |
| Johnson, KM; Jones, SM; Snell, LD | 2 |
| Javitt, DC; Jotkowitz, A; Sircar, R; Zukin, SR | 1 |
| Jacobson, AE; Koek, W; Rice, KC; Woods, JH | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Bockaert, J; Pin, JP; Van-Vliet, BJ | 1 |
| Gean, PW; Shinnick-Gallagher, P | 1 |
| Costa, E; Danysz, W; Wroblewski, JT | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Ho, PM; Tang, AH | 1 |
| Balster, RL; Willetts, J | 1 |
| Compton, RP; Contreras, PC; Monahan, JB; O'Donohue, TL | 1 |
| Baba, A; Goji, K; Kawai, N; Klenerová, V; Moroji, T; Sagi, N; Takamori, E; Yamamoto, H; Yamamoto, T | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Dumont, M; Lemaire, S; Merali, Z; Shukla, VK | 1 |
| Peeters, BW; Reijmers, LG; Vanderheyden, PM | 1 |
| Gołembiowska, K; Wedzony, K; Zazula, M | 1 |
| Coderre, TJ | 1 |
| Larson, AA; Sun, X | 1 |
| Barkai, E; Greene, RW; Grunze, HC; Hasselmo, ME; Hearn, EF; McCarley, RW; Rainnie, DG | 1 |
| Nishikawa, T; Takahashi, K; Umino, A; Yoshida, Y | 1 |
| Frandsen, A; Hansen, HS; Lauritzen, L; Schousboe, A; Strand, AM; Vinggaard, AM | 1 |
| Brinton, RD; Luu, R; Proffitt, P; Tran, J | 1 |
| Edwards, MA; Kantak, KM; O'Connor, TP | 1 |
| Stanojlovic, O; Susic, V; Zivanovic, D | 3 |
| Danysz, W; Karcz-Kubicha, M; Wedzony, K; Zajaczkowski, W | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Pilc, A; Wardas, J; Wolfarth, S; Zajaczkowski, W | 1 |
| Assmann, S; Foley, EC; Kinney, HC; Panigrahy, A; Rosenberg, PA | 1 |
| Marcus, MM; Mathé, JM; Nomikos, GG; Svensson, TH | 1 |
| Ai, J; Jardemark, KE; Ninan, I; Wang, RY | 1 |
| Ogonowski, AA; Smith, JB | 1 |
| Hivanović, D; Stanojlović, O; Susić, V | 1 |
| Chocyk, A; Fijal, K; Mackowiak, M; Wedzony, K; Zajaczkowski, W | 1 |
| Bevins, RA; Murray, JE; Polewan, RJ; Walker, AW | 1 |
1 review(s) available for 2-amino-5-phosphonovalerate and phencyclidine
| Article | Year |
|---|---|
The role of glutamate receptors in antipsychotic drug action.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds; Phencyclidine; Rats; Receptors, Metabotropic Glutamate | 2000 |
66 other study(ies) available for 2-amino-5-phosphonovalerate and phencyclidine
| Article | Year |
|---|---|
Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Iodine Radioisotopes; Kinetics; Male; Neurotoxins; Polyamines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Spermine; Synaptic Membranes; Wasp Venoms | 1991 |
Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Anticonvulsants; Corpus Striatum; Diazepam; Dizocilpine Maleate; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Phenytoin; Potassium; Pyrrolidines; Rats | 1992 |
The effect of phencyclidine and DL-2-amino-5-phosphonovaleric acid on N-methyl-D-aspartic acid induced changes in extracellular concentration of dopamine and DOPAC in the rat neostriatum.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Extracellular Space; Kinetics; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Effect of magnesium on calcium influx activated by glutamate and its agonists in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Nifedipine; Phencyclidine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Verapamil | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizocilpine Maleate; Female; Kindling, Neurologic; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Body Temperature; Dextroamphetamine; Dizocilpine Maleate; Fever; Flumazenil; Male; Mice; Phencyclidine; Pyrazoles; Pyridazines; Quinolines; Receptors, GABA-A; Receptors, Serotonin; Single-Blind Method; Stress, Physiological | 1991 |
[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate receptor participates in neuronal transmission of photic information through the retinohypothalamic tract.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arylamine N-Acetyltransferase; Hypothalamus; Light; Male; Melatonin; N-Methylaspartate; Neurons; Phencyclidine; Pineal Gland; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Retina; Suprachiasmatic Nucleus; Synaptic Transmission | 1991 |
Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Electroencephalography; Haloperidol; Isoquinolines; Kinetics; Male; Phenazocine; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Spiperone | 1991 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occlusive Diseases; Blood Pressure; Carotid Arteries; Carotid Artery Diseases; Cerebral Ventricles; Hypertension; Injections, Intraventricular; Male; Medulla Oblongata; N-Methylaspartate; Neurons; Pain; Phencyclidine; Pressoreceptors; Rats; Rats, Inbred Strains; Reflex; Vagotomy | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Haloperidol; In Vitro Techniques; Magnesium; Male; Methiothepin; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Spinal Cord | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Excitatory amino acid receptors and nociceptive neurotransmission in rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Iontophoresis; Male; Neurons; Nociceptors; Phencyclidine; Physical Stimulation; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Synaptic Transmission | 1990 |
A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Amphetamine; Animals; Apomorphine; Behavior, Animal; Central Nervous System Stimulants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glutamates; Mice; Motor Activity; Phencyclidine; Quinoxalines; Receptors, Amino Acid; Receptors, Cell Surface; Stereotyped Behavior | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Nerve Degeneration; Neurons; Oocytes; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Taurine; Xenopus | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices).
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atropine; Cerebral Cortex; Dizocilpine Maleate; Hydrolysis; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Zinc | 1990 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Behavioural and electroencephalographic effects of excitatory amino acid antagonists and sigma opiate/phencyclidine-like compounds in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Male; Phencyclidine; Pipecolic Acids; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Valine | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Excitatory amino acid blockers differentially affect bursting of in vitro hippocampal neurons in two pharmacological models of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Guinea Pigs; Hippocampus; In Vitro Techniques; Ketamine; Kynurenic Acid; Phencyclidine; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Animals, Newborn; Bicuculline; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Ketamine; Membrane Potentials; Phencyclidine; Picrotoxin; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catalepsy; Columbidae; Injections, Intraventricular; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1986 |
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Stereotyped Behavior; Valine | 1986 |
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Structure-Activity Relationship; Valine | 1987 |
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1987 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Valine | 1987 |
Inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Magnesium Sulfate; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Potassium; Rats; Rats, Inbred Strains; Valine | 1987 |
Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Chlordiazepoxide; Columbidae; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Pentobarbital; Phencyclidine; Valine | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Epileptiform activity induced by magnesium-free solution in slices of rat amygdala: antagonism by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Epilepsy; In Vitro Techniques; Magnesium; Membrane Potentials; Microelectrodes; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Injections, Intraventricular; Learning; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Scopolamine; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Ion Channels; Ligands; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
N-methyl-D-aspartate receptor antagonist activity and phencyclidine-like behavioral effects of the pentadecapeptide, [Ser1]histogranin.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Phencyclidine; Proteins; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Changes in prepulse inhibition after local administration of NMDA receptor ligands in the core region of the rat nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Male; N-Methylaspartate; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex of rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Benzazepines; Binding, Competitive; Dizocilpine Maleate; Dopamine; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Sulpiride | 1994 |
Potent analgesia induced in rats by combined action at PCP and polyamine recognition sites of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Drug Combinations; Drug Synergism; Glycine; Injections, Spinal; Male; Nociceptors; Phencyclidine; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
NMDA-dependent modulation of CA1 local circuit inhibition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dipeptides; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Female; Hippocampus; Histamine H1 Antagonists; Long-Term Potentiation; Male; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neural Inhibition; Phencyclidine; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Synaptic Transmission | 1996 |
Evidence for N-methyl-D-aspartate receptor-mediated increase in norepinephrine utilization in the prefrontal cortex of unanesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic Agents; Animals; Binding, Competitive; Consciousness; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Norepinephrine; Oxidopamine; Phencyclidine; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sympathomimetics; Tritium | 1997 |
Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Death; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Endocannabinoids; Ethanolamine; Ethanolamines; Glutamic Acid; Ionophores; Mice; Neurons; Phencyclidine; Phosphatidylethanolamines; Polyunsaturated Alkamides; Receptors, N-Methyl-D-Aspartate; Time Factors | 1997 |
Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Culture Media, Serum-Free; Dizocilpine Maleate; Equilin; Estradiol; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Excitatory Amino Acid Antagonists; Growth Substances; Microscopy, Video; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding, Competitive; Cocaine; Discrimination Learning; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Magnesium Chloride; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1998 |
APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Electroencephalography; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
The anticonvulsant potency of (+/-)-2-Amino-7-phosphonoheptanoic acid and (+/-)-2-amino-5-phosphonovaleric acid against metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Rats; Rats, Wistar; Seizures | 1998 |
Inhibition of metaphit-induced audiogenic seizures by APV in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Epilepsy, Reflex; Male; Phencyclidine; Rats; Rats, Wistar | 1999 |
NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Antimetabolites; Antipsychotic Agents; Binding Sites; Cycloleucine; Cycloserine; Disease Models, Animal; Dopamine Agents; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Hallucinogens; Locomotion; Male; Phencyclidine; Phthalazines; Protein Structure, Tertiary; Psychotic Disorders; Pyrrolidinones; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1999 |
Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Stem; Child, Preschool; Excitatory Amino Acid Antagonists; Female; Glycine; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Middle Aged; Neuroprotective Agents; Phencyclidine; Pregnancy; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Sudden Infant Death | 2000 |
Effects of competitive and non-competitive NMDA receptor antagonists on dopamine output in the shell and core subdivisions of the nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Space; Male; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2001 |
Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Phencyclidine; Piperazines; Prefrontal Cortex; Pyramidal Cells; Rats | 2001 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
[Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid].
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Male; Phencyclidine; Rats; Rats, Wistar; Seizures | 2002 |
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Male; Maze Learning; Phencyclidine; Pregnancy; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Social Behavior | 2008 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |