2-amino-5-phosphonovalerate has been researched along with dizocilpine maleate in 497 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (4.02) | 18.7374 |
| 1990's | 335 (67.40) | 18.2507 |
| 2000's | 112 (22.54) | 29.6817 |
| 2010's | 29 (5.84) | 24.3611 |
| 2020's | 1 (0.20) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, J; Kim, SR; Kim, YC; Koo, KA; Lee, KY; Lee, NG; Sung, SH | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Nellgård, B; Wieloch, T | 3 |
| Hansen, AJ; Lauritzen, M | 1 |
| Felipo, V; Grisolía, S; Hermenegildo, C; Marcaida, G; Miñana, MD | 1 |
| Kretschmer, BD; Schmidt, WJ; Volz, L; Volz, TL; Zadow, B | 1 |
| Jensen, TS; Yaksh, TL | 1 |
| Sage, GP; Sethy, VH | 1 |
| Hisanaga, K; Sagar, SM; Sharp, FR | 1 |
| Dawes, E; Hankins, M; Ikeda, H | 1 |
| Gorter, JA; Mirmiran, M; Veerman, M | 1 |
| Fink, K; Göthert, M | 3 |
| Ishii, T; Masu, M; Moriyoshi, K; Nakanishi, S; Sugihara, H | 1 |
| Ebert, U; Koch, M | 1 |
| Dichter, MA; Molinoff, PB; Williams, K | 1 |
| Bonaventure, N; Jardon, B | 1 |
| Bischoff, C; Tiedtke, PI | 1 |
| Barnabei, O; Contestabile, A; Migani, P; Virgili, M | 1 |
| Halsted, MJ; Hockfield, S; Kalb, RG; Lidow, MS | 1 |
| Peeters, BW; Vanderheyden, PM | 1 |
| Bagetta, G; Dolly, JO; Nisticó, G | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| Pai, KS; Ravindranath, V | 1 |
| Constantine-Paton, M; O'Leary, DD; Prusky, GT; Simon, DK | 1 |
| Arnold, G; Burg, M; Kupsch, A; Löschmann, PA; Oertel, WH; Pufal, D; Renner, P; Sauer, H; ten Bruggencate, G; Wachtel, H | 1 |
| Dziki, M; Hönack, D; Löscher, W | 1 |
| Allegrini, PR; Sauer, D | 1 |
| Baraban, JM; Blatter, LA; Murphy, TH; Wier, WG | 1 |
| Marini, AM; Paul, SM; Weller, M | 1 |
| Bagetta, G; Nisticò, G | 1 |
| Bubser, M; Keseberg, U; Notz, PK; Schmidt, WJ | 1 |
| Costantino, M; Cristina, FM; Cristina, GA; Giovanni, B; Mariangela, S | 1 |
| Bagetta, G; Bowery, NG; Britton, P; Nisticó, G; Whitton, P | 1 |
| Garrone, B; Pittaluga, A; Raiteri, M | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Gottesman, J; Miller, RF | 1 |
| Akaike, N; Himori, N; Imai, M; Matsukura, T; Watanabe, H | 1 |
| Dreifuss, JJ; Raggenbass, M; Widmer, H | 1 |
| Boje, K; Miller, R; Skolnick, P; Trullas, R; Young, A | 1 |
| Chiorri, C; Cordi, AA; Dappen, MS; Monahan, JB; Natalini, B; Pellicciari, R | 1 |
| Hönack, D; Löscher, W | 2 |
| Crane, AM; Driscoll, BF; Law, MJ | 1 |
| Borsini, F; Gragnani, L; Lecci, A; Meli, A; Volterra, G | 1 |
| Klunk, WE; McClure, RJ; Pettegrew, JW | 1 |
| Kihara, M; Kubo, T; Misu, Y | 1 |
| Ceccaldi, PE; Ermine, A; Guillemer, S; Lockhart, B; Tsiang, H | 1 |
| Liljequist, S | 1 |
| Hahm, JO; Langdon, RB; Sur, M | 1 |
| Anderton, PJ; Millar, TJ | 1 |
| Kuramoto, K; Nishimura, S; Sorimachi, M | 1 |
| Baron, BM; Chi, EM; Harrison, BL; Kehne, JH; McCloskey, TC; Palfreyman, MG; Whitten, JP | 1 |
| Monaghan, DT | 1 |
| Chronister, RB; Joshi, RS; Marco, LA | 1 |
| Bandopadhyay, R; de Belleroche, J | 1 |
| Dreyer, EB; Kaiser, PK; Lipton, SA; Sucher, NJ | 1 |
| Fassbender, CP; Hönack, D; Löscher, W | 1 |
| Beilin, B; Cohn, S; Ginzburg, R; Seltzer, Z | 1 |
| Canton, H; Colpaert, F; Lehmann, J | 1 |
| Rawlins, JN; Tonkiss, J | 1 |
| Daniell, LC | 1 |
| Kam, T; Maretić, H; Morishita, W; Sastry, BR; Xie, Z | 1 |
| Choi, DW; Goldberg, MP; Kaku, DA | 1 |
| Paton, JF; Rogers, WT; Schwaber, JS | 1 |
| Gribkoff, VK | 1 |
| Fredow, G; Löscher, W; Richter, A | 1 |
| Cherubini, E; Kilić, G; Moran, O | 1 |
| Frusciante, MJ; Javitt, DC; Nussenzveig, IZ; Sircar, R; Wong, ML; Zukin, SR | 1 |
| Coulter, DA; DeLorenzo, RJ; Sombati, S | 1 |
| Cuénod, M; Do, KQ; Fontana, A; Frei, K; Piani, D | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Swartz, KJ | 1 |
| McMillian, M; Miller, LG; Schatzki, A | 1 |
| Katki, AG; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| Bartrup, JT; Stone, TW | 1 |
| Cline, HT; Tsien, RW | 1 |
| Bigalke, H; Lampe, H | 1 |
| Linn, DM; Massey, SC | 1 |
| Clow, DW; Hammer, RP; Lee, SJ | 1 |
| Lipton, P; Lobner, D | 1 |
| Brenneman, DE; Forsythe, ID; Nelson, PG; Nicol, T | 1 |
| Ojeda, SR; Urbanski, HF | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Levy, DI; Lipton, SA | 1 |
| Harley, C; Heale, V | 1 |
| Labruyere, J; Olney, JW; Price, MT; Stewart, GR; Wang, GJ; Zorumski, CF | 1 |
| Gotoh, Y; Ishida, M; Shinozaki, H | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Shirasaki, T; Tateishi, N | 1 |
| Cannon-Spoor, HE; Freed, WJ | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Dickenson, AH; Haley, JE; Sullivan, AF | 1 |
| Fink, K; Göthert, M; Schlicker, E | 1 |
| Egert, U; Kossel, A; Rauschecker, JP | 1 |
| Boksa, P; Chaudieu, I; Mount, H; Quirion, R | 1 |
| Gross, GW; Lucas, JH; Wang, GF | 1 |
| Hoehn, K; White, TD | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Girault, JA; Greengard, P; Halpain, S | 1 |
| Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Skolnick, P; Trullas, R | 1 |
| Jope, RS; Li, X; Ormandy, GC | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
| Javitt, DC; Zukin, SR | 1 |
| Buerki, H; Fagg, GE; Mondadori, C; Petschke, F; Weiskrantz, L | 1 |
| Champagnat, J; Denavit-Saubié, M; Foutz, AS | 1 |
| Arnolde, SM; Nevins, ME | 1 |
| Chambers, G; Cottrell, JE; Kass, IS | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Beart, PM; Lodge, D; Manallack, DT | 1 |
| Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Cox, JA; Henneberry, RC; Lysko, PG; Vigano, MA | 1 |
| Cline, HT; Constantine-Paton, M | 1 |
| Lehmann, J; Tsai, C; Wood, PL | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Foster, AC; Wong, EH | 1 |
| Childs, AM; Evans, RH; Watkins, JC | 1 |
| Dewhurst, DG | 1 |
| Kloog, Y; Nadler, V; Sokolovsky, M | 1 |
| Connick, JH; Stone, TW | 1 |
| Ho, PM; Tang, AH | 1 |
| Payne, RS; Rigor, BM; Schurr, A | 1 |
| Hauber, W; Münkle, M | 2 |
| Backus, KH; Trube, G | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Laurie, DJ; Seeburg, PH | 1 |
| Baba, A; Goji, K; Kawai, N; Klenerová, V; Moroji, T; Sagi, N; Takamori, E; Yamamoto, H; Yamamoto, T | 1 |
| Devillers, JP; Simonnet, G | 1 |
| Han, D; Ogita, K; Yoneda, Y | 2 |
| Schmidt, WJ; Tzschentke, TM | 2 |
| Arai, K; Fujita, T; Ishizaki, K; Yamazaki, M; Yoon, DM; Yoshida, N | 1 |
| London, ED; Mukhin, A | 1 |
| Bradberry, CW; Pap, A | 1 |
| Dall'Olio, R; Gandolfi, O; Rimondini, R | 3 |
| Eki, T; Karp, SJ; Masu, M; Nakanishi, S; Ozawa, K | 1 |
| Bessho, Y; Nakanishi, S; Nawa, H | 1 |
| Ferrer-Montiel, AV; Montal, M; Planells-Cases, R; Sun, W | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Little, HJ; Rabbani, M; Wright, EJ | 1 |
| Chao, CC; Hu, S | 1 |
| Coderre, TJ; Van Empel, I | 1 |
| Peeters, BW; Reijmers, LG; Vanderheyden, PM | 1 |
| Kalb, RG | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Gonzales, RA; Roper, LC | 1 |
| Hartikainen, T; Koivisto, E; Pitkänen, M; Riekkinen, PJ; Sirviö, J; Sivenius, J; Ylinen, A | 1 |
| Barnabei, O; Contestabile, A; Virgili, M | 1 |
| Cameron, HA; Gould, E; McEwen, BS | 2 |
| Nowak, G; Ordway, GA; Paul, IA | 1 |
| Millan, MJ; Seguin, L | 1 |
| Moryl, E; Papp, M | 1 |
| Feuerstein, TJ | 1 |
| Flores, A; Soto, E; Vega, R | 1 |
| Carlsson, A; Carlsson, ML; Svensson, A | 2 |
| Borowitz, JL; Isom, GE; Pavlakovic, G; Rathinavelu, A; Sun, P | 1 |
| Starr, BS; Starr, MS | 3 |
| Enomoto, R; Ishitsubo, N; Nakahara, F; Ogita, K; Yoneda, Y | 1 |
| Wieraszko, A | 2 |
| Folbergrová, J | 2 |
| King, AJ; Schnupp, JW; Smith, AL; Thompson, ID | 1 |
| Gołembiowska, K; Wedzony, K; Zazula, M | 1 |
| Archer, T; Fredriksson, A; Gentsch, C | 1 |
| Aronstam, RS; Dennison, RL; Martin, DC | 1 |
| Allegrini, PR; Fagg, GE; Sauer, D | 1 |
| Connor, JA; Petrozzino, JJ | 1 |
| Jessa, M; Nazar, M; Palejko, W; Plaznik, A | 1 |
| Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP | 1 |
| Daszuta, A; Forni, C; Moukhles, H; Nieoullon, A | 1 |
| Ishikawa, K; Kogure, M; Shibanoki, S; Sugahara, M | 1 |
| Han, D; Ogita, K; Suzuki, T; Yoneda, Y; Zuo, P | 1 |
| López-Colomé, AM; Ortega, A; Romo-de-Vivar, M | 1 |
| Bilkey, DK; Yamada, N | 1 |
| Coderre, TJ | 1 |
| Durand, J | 1 |
| Liang, KC; Lin, MH; Tyan, YM | 1 |
| Annies, R; Hönack, D; Löscher, W | 1 |
| Hönack, D; Löscher, W; Rundfeldt, C | 1 |
| Paul, SM; Weller, M | 1 |
| Dubner, R; Ren, K | 1 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Challis, RA; Gray, DW; Mistry, R; Nahorski, SR | 1 |
| Bowery, NG; Carletti, R; Gaviraghi, G; Ratti, E | 1 |
| Puro, DG; Uchihori, Y | 1 |
| Caramanos, Z; Shapiro, ML | 1 |
| Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q | 1 |
| Bongrani, S; Dall'Olio, R; Gandolfi, O; Rimondini, R; Valsecchi, B | 1 |
| Berrino, L; Leyva, J; Maione, S; Pizzirusso, A; Rossi, F; Stella, L | 1 |
| Scholfield, CN; Yassin, M | 1 |
| Challiss, RA; Gray, DW; Mistry, R; Nahorski, SR | 1 |
| Aizenman, E; Blitzblau, RC; Hartnett, KA; Rosenberg, PA; Speliotes, EK | 1 |
| Fung, ML; St John, WM; Wang, W | 1 |
| Biggio, G; Foddi, MC; Ghiani, CA; Motzo, C; Serra, M | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Facchinetti, F; Sparapani, M; Virgili, M | 1 |
| Starr, JB; Werling, LL | 1 |
| Hatipoğlu, I; Koyuncuoğlu, H; Sarica, O | 1 |
| Ohta, H; Talman, WT | 1 |
| Amalric, M; Baunez, C; Nieoullon, A | 1 |
| Hasegawa, T; Kameyama, T; Kinoshita, H; Nabeshima, T; Yamamoto, I | 1 |
| Kinney, GG; Kocsis, B; Vertes, RP | 1 |
| Amalric, M; Baunez, C; Nieoullon, A; Ouagazzal, A | 1 |
| McEwen, BS; Woolley, CS | 1 |
| Hashim, MA; Tadepalli, AS | 1 |
| Abe, S; Akazawa, K; Chishaki, A; Goto, Y; Kato, M; Nakamura, M | 1 |
| Couratier, P; Dumas, M; Hugon, J; Sindou, P; Vallat, JM | 1 |
| Leung, LS; Shen, B | 2 |
| Balster, RL; Gold, LH | 1 |
| Ball, GF; Wieraszko, A | 1 |
| Giacobini, E; Matsuoka, Y; Naritoku, D; Rakonczay, Z | 1 |
| Boje, KM; Skolnick, P; Wong, G | 1 |
| Komuro, H; Rakic, P | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P; Trullas, R | 1 |
| Borghese, CM; Gómez, RA; Ramírez, OA | 1 |
| Black, IB; Dreyfus, CF; Mount, HT | 1 |
| Larson, AA; Sun, X | 1 |
| Dumont, M; Ibrahim, IH; Lapierre, C; Lemaire, S; Parent, P; Rogers, C; Shukla, VK | 1 |
| al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Lewis, SJ; Ohta, H; Talman, WT | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Facchinetti, F; Fonnum, F; Virgili, M | 1 |
| Bianchi, L; Giovannini, MG; Michelassi, A; Mutolo, D; Pepeu, G | 1 |
| Baran, H; Du, F; French, ED; McMaster, OG; Schwarcz, R; Wu, HQ | 1 |
| Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C | 1 |
| Cordery, PM; Smith, AL; Thompson, ID | 1 |
| Lu, L; Mcgonigle, P; Munir, M | 1 |
| Atack, JR; Barton, C; Cockett, W; Cook, SM; Gilbert, E; Grimwood, S; Hutson, PH; Le Bourdellès, B; McKernan, RM; Myers, J; Ragan, CI; Whiting, PJ; Wingrove, PB | 1 |
| Bures, J; Motaghed-Larijani, Z; Rashidy-Pour, A | 1 |
| Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F | 1 |
| Liesi, P; Wright, JM | 1 |
| Huganir, RL; Moshaver, A; Raymond, LA; Tingley, WG | 1 |
| London, ED; Matsunaga, T; Mukhin, AG | 1 |
| Cabrera, RJ; Navarro, CE | 1 |
| Jaw, SP; Nguyen, M; Vuong, QT | 1 |
| Czyrak, A; Fijał, K; Maćkowiak, M; Wedzony, K | 1 |
| Ikeda, K; Iwasaki, Y; Kinoshita, M; Shiojima, T | 1 |
| Gall, CM; Guthrie, KM; Sullivan, RM; Wilson, DA | 1 |
| Bodnar, RJ; Cooper, ML; Spinella, M | 1 |
| Amalric, M; Ouagazzal, A | 1 |
| Du, B; Hatch, WC; Price, P; Terwilliger, EF; Wu, P | 1 |
| Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME | 1 |
| Cherng, CH; Ho, ST; Luk, HN; Tung, CS; Wong, CS | 1 |
| Yamazaki, M | 1 |
| Bidzinski, A; Jessa, M; Nazar, M; Plaznik, A | 1 |
| Moryl, E; Papp, M; Zajaczkowski, W | 1 |
| Couratier, P; Dussartre, C; Hugon, J; Lesort, M; Terro, F | 1 |
| Czyrak, A; Wedzony, K | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Biggs, CS; Fowler, LJ; Starr, MS; Whitton, PS | 1 |
| Chao, CC; Ehrlich, L; Hu, S; Peterson, PK | 1 |
| Mitrovic, N; Mohajeri, H; Schachner, M | 1 |
| Berretta, N; Jones, RS | 1 |
| Arnolda, L; Chalmers, J; Llewellyn-Smith, I; Minson, J; Miyawaki, T; Pilowsky, P | 1 |
| Bienkowski, P; Kostowski, W; Stefanski, R | 1 |
| Leonardi, EK; Mytilineou, C; Olanow, CW; Radcliffe, P; Werner, P | 1 |
| Maccecchini, ML; Moryl, E; Papp, M | 1 |
| Chaplan, SR; Malmberg, AB; Yaksh, TL | 1 |
| Borowitz, JL; Gunasekar, PG; Isom, GE; Rane, SG; Sun, P | 1 |
| Giles, K; Greenfield, SA; Nedergaard, S; Webb, CP | 1 |
| Ciani, E; Contestabile, A; Paulsen, RE; Rizzi, S | 1 |
| Buccafusco, JJ; Feldman, DS | 1 |
| Cory-Slechta, DA; Garcia-Osuna, M; Greenamyre, JT | 1 |
| Gustafsson, B; Pananceau, M | 1 |
| Arnelle, DR; Choi, YB; D'Emilia, DM; Kim, WK; Kumar, S; Lipton, SA; Rayudu, PV; Stamler, JS | 1 |
| Chuang, DM; Lin, WW; Wang, CW | 1 |
| Barth, A; Malouf, AT; Newell, DW; Ricciardi, TN | 1 |
| Ameri, A; Peters, T | 1 |
| Geppert, M; Goda, Y; Stevens, CF; Südhof, TC | 1 |
| Furukawa, K; Holtsberg, FW; Keller, JN; Mattson, MP; Steiner, MR; Steiner, SM | 1 |
| Dorandeu, F; Fosbraey, P; Lallement, G; Pernot-Marino, I; Tattersall, JE; Wetherell, J | 1 |
| Niu, YP; Wigstrom, H; Xiao, MY | 1 |
| Danysz, W; Frankiewicz, T; Parsons, CG; Zajaczkowski, W | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Jessa, M; Nazar, M; Płaźnik, A | 1 |
| Cabello, P; Contreras, E; Germany, A; González, P; Norris, B | 1 |
| Artemowicz, B; Lutostańska, A; Wiśniewski, K | 1 |
| Brinton, RD; Luu, R; Proffitt, P; Tran, J | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Lemaire, S; Prasad, JA; Shukla, VK | 1 |
| Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T; Yanase, T | 1 |
| Crews, FT; Iimuro, Y; Rudolph, JG; Thurman, RG; Walker, DW | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Bienkowski, P; Koros, E; Kostowski, W; Piasecki, J | 1 |
| Aanonsen, L; Hargreaves, KM; Richardson, JD | 1 |
| Edwards, MA; Kantak, KM; O'Connor, TP | 1 |
| Brennan, TJ; Zahn, PK | 1 |
| Cronin, AS; Ebling, FJ | 1 |
| Grover, LM | 1 |
| Andreas, K; Häntzschel, A | 1 |
| Hamba, M | 1 |
| Carstens, E; Jinks, SL | 1 |
| Compagnone, NA; Mellon, SH | 1 |
| Burt-Pichat, B; Chenu, C; Delmas, PD; Raynal, C; Serre, CM | 1 |
| Kobayashi, M; Mochizuki, M; Terashima, T; Yokogoshi, H | 1 |
| Constantine-Paton, M; Lin, SY | 1 |
| Becker, A; Hoellt, V; Schroeder, H | 1 |
| Zhuo, M | 1 |
| Fowler, CJ; Hedin, H; Jacobsson, SO; Sellström, A | 1 |
| Braisted, JC; Chavko, M; Harabin, AL | 1 |
| Boje, KM; Lakhman, SS | 1 |
| Kinzie, JM; Sahara, Y; Schoppa, NE; Segerson, TP; Westbrook, GL | 1 |
| Araque, A; Haydon, PG; Parpura, V; Sanzgiri, RP | 1 |
| McNally, GP; Westbrook, RF | 1 |
| Wlaź, P | 1 |
| Bon, CL; Greenfield, SA; Paulsen, O | 1 |
| Magistretti, PJ; Martin, JL; Pellegri, G | 1 |
| Haberly, LB; Kapur, A | 1 |
| Fossom, LH; Lin, Y; Long, JB; Skolnick, P | 1 |
| DeLorenzo, RJ; Pal, S; Sombati, S | 1 |
| Boulu, RG; Callebert, J; Lancelot, E; Plotkine, M; Revaud, ML | 1 |
| Aguilar, E; Dieguez, C; Gonzalez, L; Pinilla, L; Tena-Sempere, M | 1 |
| Mienville, JM; Pesold, C | 1 |
| Badre, SE; Morsette, DJ; Sladek, CD; Swenson, KL | 1 |
| Anderson, KJ; Freund, G | 1 |
| Dreyer, EB; Grosskreutz, CL; Heng, JE; Vorwerk, CK; Zurakowski, D | 1 |
| Batchelor, RH; Dorsa, DM; Figueroa-Masot, XA; Singer, CA | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Fushiki, S; Hasegawa, K; Hirai, K; Kihara, M; Sakamoto, T; Sawada, T; Yoshioka, H | 1 |
| Goshima, Y; Kawashima, K; Misu, Y; Miyamae, T; Ohshima, E; Shibata, T; Shimizu, M; Suzuki, F | 1 |
| Alavez, S; Hurtado, S; Moran, J; Rivera-Gaxiola, M; Valencia, A | 1 |
| Linden, R; Martins, RA; Rocha, M | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
| Bodnar, RJ; Moroz, M; Ragnauth, A; Spinella, M; Znamensky, V | 1 |
| Butler, AK; Chesselet, MF; Rougon, G; Uryu, K | 1 |
| Brundin, P; Schierle, GS | 1 |
| Grover, LM; Yan, C | 1 |
| Archer, T; Chase, T; Fredriksson, A; Palomo, T | 1 |
| Cramer, KS; Hahm, JO; Sur, M | 1 |
| Matsuda, I; Ohyashiki, T; Takadera, T | 1 |
| Kretschmer, BD | 1 |
| Bäckström, P; Hyytiä, P; Liljequist, S | 1 |
| Halpain, S; Steward, O | 1 |
| Ahn, YH; Hwang, JY; Kim, YH; Koh, JY; Wie, MB | 1 |
| Geiger, JD; Haughey, NJ; Holden, CP; Nath, A | 1 |
| Cornish, JL; Duffy, P; Kalivas, PW | 1 |
| Cebers, G; Kovács, AD; Liljequist, S | 1 |
| Burritt, A; Gandhoke, R; Hruby, VJ; Lai, J; Porreca, F; Tang, Q | 1 |
| De Laurentiis, A; Díaz, MC; Duvilanski, B; Lasaga, M; Pampillo, M; Pisera, D; Seilicovich, A | 1 |
| Standley, CA | 1 |
| Fontana, A; Gerber, U; Heuss, C; Malipiero, U; Schlapbach, R; Tschopp, J | 1 |
| Katsuyama, S; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K | 1 |
| Ezure, K; Miyazaki, M; Tanaka, I | 1 |
| Foldes, JK; Hauser, KF; Turbek, CS | 1 |
| Borress, R; Buzzard, M; Dhillon, S; Schmidt, JT | 1 |
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| Abraham, WC; Ireland, DR; Raymond, CR | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shibata, H; Takenaka, C | 1 |
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| Chau, DT; Gonzalez, LE; Harrison, T; Hernandez, L; Hoebel, BG; Moreno, SA; Rada, P; Tucci, S | 1 |
| Ogonowski, AA; Smith, JB | 1 |
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| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Nishikawa, H; Sugimoto, H; Taguchi, R; Terauchi, T; Yonaga, M | 1 |
| Garraway, SM; Mendell, LM; Petruska, JC | 1 |
| Ehlers, MD; Horton, AC; Mu, Y; Otsuka, T; Scott, DB | 1 |
| Hozumi, S; Kisara, K; Murata, A; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Yamadera, F | 1 |
| Asai, S; Du, JZ; Liu, JX; Shi, ZQ; Taya, K; Watanabe, G | 1 |
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| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Concas, A; Marino, G; Minei, R; Pierobon, P; Porcu, P; Sogliano, C; Tino, A; Tortiglione, C | 1 |
| Grantyn, R; Henneberger, C; Jüttner, R; Meier, JC; Rothe, T; Schmidt, SA; Walter, J | 1 |
| Paré, D; Samson, RD | 1 |
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| Hori, K; Kobayashi, M; Masaki, T; Masuo, Y; Miyamoto, M; Noguchi, H; Nomura, M; Takamatsu, K; Tsubokawa, H | 1 |
| Buchheim, K; Dirnagl, U; Dreier, JP; Drenckhahn, C; Gabriel, S; Haack, S; Heinemann, U; Lehmann, TN; Major, S; Megow, D; Meierkord, H; Peters, O; Petzold, GC; Windmüller, O | 1 |
| Beneyto, M; Dean, B; Meador-Woodruff, JH; Scarr, E | 1 |
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| Mares, P; Slamberová, R | 1 |
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| Cairns, BE; Hu, JW; Lam, DK; Sessle, BJ | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
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| Brager, DH; Chen, X; Chitwood, RA; Fan, Y; Fricker, D; Johnston, D; Lu, HC | 1 |
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| Cao, J; Dong, ZF; Luo, JH; Tian, M; Xu, L; Zhong, WX | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Alfonso, M; Campos, F; Durán, R; Faro, LR; Vidal, L | 1 |
| Fossat, P; Landry, M; Le Masson, G; Nagy, F; Sibon, I | 1 |
| Inoue, H; Okada, Y | 1 |
| Gheitasi, IP; Haghparast, A; Lashgari, R | 1 |
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| Fathollahi, Y; Kazemnejad, A; Naghdi, N; Semnanian, S; Soleimannejad, E | 1 |
| Esashi, A; Furuta, S; Nakagawasai, O; Niijima, F; Sato, T; Satoh, S; Tadano, T; Tan-No, K; Yasuhara, H | 1 |
| Butler, TR; Ghayoumi, L; Holley, RC; Littleton, JM; Mullins, MM; Prendergast, MA; Self, RL; Smith, KJ | 1 |
| Alfonso, M; Campos, F; Cervantes, RC; Durán, R; Faro, LF; Vidal, L | 1 |
| Bai, D; Gong, XQ; Zabek, RL | 1 |
| Fidecka, S; Kedzierska, E; Nieoczym, D; Nowak, G; Pilc, A; Poleszak, E; Wlaź, P; Wróbel, A | 1 |
| Kim, JH; Langton, JM; Nicholas, J; Richardson, R | 1 |
| García-Bereguiaín, MA; Gutiérrez-Merino, C; Martín-Romero, FJ; Samhan-Arias, AK | 1 |
| Jones, RS; Wetterstrand, C; Yang, J | 1 |
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| Covington, HE; Kosofsky, BE; Miczek, KA; Rajadhyaksha, AM; Tropea, TF | 1 |
| Paulsen, O; Rodríguez-Moreno, A | 1 |
| Caruana, DA; Chapman, CA; Glasgow, SD; Kourrich, S | 1 |
| Butler, VJ; Everitt, BJ; Gardner, R; Lee, JL; Milton, AL | 1 |
| Rassouli, Y; Rezayof, A; Sharifi, K; Zarrindast, MR | 1 |
| Dringenberg, HC; Habib, D | 1 |
| Darden, TA; Huang, Y; Li, W; Mahadevan, A; Malpica-Llanos, T; Nath, A; Reid, R; Satishchandra, P; Shankar, SK; Steiner, J | 1 |
| Allan, AM; Caldwell, KK; Perrone-Bizzozero, NI; Samudio-Ruiz, SL; Valenzuela, CF | 1 |
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| Berry, JN; Butler, TR; Littleton, JM; Mulholland, PJ; Pauly, JR; Prendergast, MA; Self, RL; Sharrett-Field, LJ; Smith, KJ | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Bellec, Y; Brière, C; Cotelle, V; Da Silva, D; Faure, JD; Graziana, A; Jauneau, A; Lachaud, C; Mazars, C; Ranjeva, R; Thuleau, P; Xiong, TC | 1 |
| Dringenberg, HC; Hager, AM | 1 |
| Chen, H; Chen, SR; Pan, HL; Zhou, HY | 1 |
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| Brandão, ML; Coimbra, NC; Ferrari, EA; Francisco, A; Maisonnette, SS; Medeiros, P; Mello, RO; Melo, LL; Santos, P | 1 |
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| Berger, M; Freidl, M; Gabor, F; Neuhaus, W; Noe, CR; Pifl, C; Szkokan, P; Winkler, J; Wirth, M | 1 |
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| Björefeldt, A; Blomgren, K; Carlström, KE; Daborg, J; Ekdahl, CT; Hanse, E; Kalm, M; Pekna, M; Perez-Alcazar, M; Stokowska, A; Wasling, P; Zetterberg, H | 1 |
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1 review(s) available for 2-amino-5-phosphonovalerate and dizocilpine maleate
| Article | Year |
|---|---|
Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; Acetamides; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Central Nervous System; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Neurotoxicity Syndromes; Rats; Receptors, N-Methyl-D-Aspartate | 2002 |
496 other study(ies) available for 2-amino-5-phosphonovalerate and dizocilpine maleate
| Article | Year |
|---|---|
Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Fetus; Glutamic Acid; Glycosides; Iridoids; Molecular Structure; Neuroglia; Neurons; Neuroprotective Agents; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Scrophularia; Stereoisomerism | 2002 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cell Membrane Permeability; Cortical Spreading Depression; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Ion Channels; Male; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1992 |
The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Cortex; Cortical Spreading Depression; Dizocilpine Maleate; Electrophysiology; Ischemic Attack, Transient; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Glucose; Blood Pressure; Body Temperature; Cell Death; Dizocilpine Maleate; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors.
Topics: Ammonia; Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1992 |
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Catalepsy; Cycloserine; Dizocilpine Maleate; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Brain Stem; Diencephalon; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Medulla Oblongata; Mesencephalon; Microinjections; N-Methylaspartate; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Reticular Formation; Stereotaxic Techniques | 1992 |
Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Anticonvulsants; Corpus Striatum; Diazepam; Dizocilpine Maleate; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Phenytoin; Potassium; Pyrrolidines; Rats | 1992 |
N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Signal Transduction | 1992 |
Spontaneous firing level distinguishes the effects of NMDA and non-NMDA receptor antagonists on the ganglion cells in the cat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cats; Dizocilpine Maleate; Evoked Potentials, Visual; Ganglia; Iontophoresis; Kynurenic Acid; Piperazines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Retina | 1992 |
Hippocampal neuronal responsiveness to NMDA agonists and antagonists in the adult rat neonatally treated with MK-801.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Hippocampus; Iontophoresis; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Presynaptic site of action underlying the ethanol-induced inhibition of norepinephrine release evoked by stimulation of N-methyl-D-aspartate (NMDA) receptors in rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Calcium; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrodotoxin | 1992 |
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Chromosome Deletion; Cloning, Molecular; Dizocilpine Maleate; DNA; Gene Library; Kynurenic Acid; Molecular Sequence Data; N-Methylaspartate; Oocytes; Piperazines; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Restriction Mapping; RNA Splicing; RNA, Messenger; Xenopus | 1992 |
Glutamate receptors mediate acoustic input to the reticular brain stem.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acoustic Stimulation; Animals; Dizocilpine Maleate; Evoked Potentials, Auditory, Brain Stem; Female; Glutamates; Iontophoresis; Pons; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Reticular Formation | 1992 |
Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Neurons; Pipecolic Acids; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 1992 |
N-methyl-D-aspartate antagonists suppress the development of frog symmetric monocular optokynetic nystagmus observed after unilateral visual deprivation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraperitoneal; Magnetics; Microinjections; N-Methylaspartate; Nystagmus, Physiologic; Pipecolic Acids; Rana esculenta; Receptors, N-Methyl-D-Aspartate; Vision, Monocular | 1992 |
Competitive and non-competitive NMDA receptor antagonists in spatial learning tasks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Learning; Male; Memory; Motor Activity; Orientation; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Epilepsy; Kainic Acid; Male; Neuroglia; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Syndrome | 1992 |
N-methyl-D-aspartate receptors are transiently expressed in the developing spinal cord ventral horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamates; Motor Neurons; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Strychnine | 1992 |
Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Diseases; Dizocilpine Maleate; Elapid Venoms; Electroencephalography; Hippocampus; Injections; Male; Nerve Degeneration; Neurotoxins; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
Quisqualic acid-induced neurotoxicity is protected by NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ion Channel Gating; L-Lactate Dehydrogenase; Mice; Potassium; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1992 |
N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Axons; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Drug Implants; Polyvinyls; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1992 |
Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Catecholamines; Corpus Striatum; Dizocilpine Maleate; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase | 1992 |
Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Synergism; Female; Kindling, Neurologic; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinical Enzyme Tests; Constriction; Dizocilpine Maleate; Glutamate Decarboxylase; Ischemic Attack, Transient; Magnetic Resonance Imaging; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Inbred F344 | 1992 |
Spontaneous synchronous synaptic calcium transients in cultured cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Electrophysiology; Fetus; Fluorescent Dyes; Kainic Acid; Kinetics; Membrane Potentials; Microscopy, Fluorescence; Neurons; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin; Time Factors | 1992 |
Niacinamide blocks 3-acetylpyridine toxicity of cerebellar granule cells in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Mazindol; N-Methylaspartate; Neurons; Niacinamide; Pyridines; Rats; Rats, Sprague-Dawley; Selegiline; Tetrahydrofolates | 1992 |
Glutamate transmission is involved in the mechanisms of neuronal degeneration produced by intrahippocampal tetanus toxin in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Male; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetanus Toxin | 1992 |
Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dopamine; Male; Memantine; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
The degeneration of the excitatory climbing fibers enhances [3H]MK-801 and [3H]CGP 39653 binding sites in the rat cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellar Cortex; Dizocilpine Maleate; Kinetics; Male; Nerve Degeneration; Nerve Fibers; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Cell Death; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Insulin Coma; Male; Necrosis; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1992 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; Epilepsy, Generalized; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetanus Toxin | 1992 |
N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. II. Evidence for functional cooperation and for coexistence on the same axon terminal.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Dizocilpine Maleate; Drug Interactions; Hippocampus; Ibotenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Pharmacological properties of N-methyl-D-aspartate receptors on ganglion cells of an amphibian retina.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Electrodes; In Vitro Techniques; Ion Channels; Kynurenic Acid; Magnesium; Perfusion; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Tetrodotoxin; Zinc | 1992 |
Replenishment of brain adenosine triphosphate content by morphinan-type N-methyl-D-asparatate receptor antagonists, dextrorphan and dextromethorphan through the activation of adenylate kinase.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Adenylate Kinase; Amino Acids; Animals; Brain Chemistry; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Enzyme Activation; Male; Mice; Morphinans; Potassium Cyanide; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
N-methyl-D-aspartate and vasopressin activate distinct voltage-dependent inward currents in facial motoneurones.
Topics: Animals; Arginine Vasopressin; Brain Stem; Dizocilpine Maleate; Electric Conductivity; Evoked Potentials; Facial Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Valine | 1992 |
Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Learning; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Swimming | 1992 |
Synthesis and biological evaluation of cyclopropyl analogues of 2-amino-5-phosphonopentanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Indicators and Reagents; Kainic Acid; Kinetics; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes; Tritium | 1991 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizocilpine Maleate; Female; Kindling, Neurologic; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Cell damage associated with changing the medium of mesencephalic cultures in serum-free medium is mediated via N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Buffers; Cells, Cultured; Culture Media; Dizocilpine Maleate; Glutamates; Glutamic Acid; Mesencephalon; N-Methylaspartate; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1991 |
Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Body Temperature; Dextroamphetamine; Dizocilpine Maleate; Fever; Flumazenil; Male; Mice; Phencyclidine; Pyrazoles; Pyridazines; Quinolines; Receptors, GABA-A; Receptors, Serotonin; Single-Blind Method; Stress, Physiological | 1991 |
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glycine; Kainic Acid; N-Methylaspartate; Phosphoserine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Ipsilateral but not contralateral blockade of excitatory amino acid receptors in the caudal ventrolateral medulla inhibits aortic baroreceptor reflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aorta; Blood Pressure; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Muscimol; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Reflex; Synaptic Transmission | 1991 |
Inhibition of rabies virus infection in cultured rat cortical neurons by an N-methyl-D-aspartate noncompetitive antagonist, MK-801.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dizocilpine Maleate; N-Methylaspartate; Neurons; Rabies; Rabies virus; Rats; Virus Replication | 1991 |
The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Diet; Dizocilpine Maleate; Ethanol; Hippocampus; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1991 |
The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kindling, Neurologic; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Receptors, Serotonin | 1991 |
Disruption of retinogeniculate afferent segregation by antagonists to NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Dizocilpine Maleate; Ferrets; Geniculate Bodies; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retinal Ganglion Cells; Visual Pathways | 1991 |
Effects of excitatory amino acids and their antagonists on the light response of luminosity and color-opponent horizontal cells in the turtle (Pseudemys scripta elegans) retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Color Perception; Dizocilpine Maleate; Electrophysiology; Kainic Acid; Light; N-Methylaspartate; Photic Stimulation; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Turtles | 1991 |
Receptor types mediating the rise in the cytosolic free calcium concentration by L-aspartate and L-glutamate in immature cerebellar neurons with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kinetics; Magnesium; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety, Separation; Behavior, Animal; Buspirone; Diazepam; Dioxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Indoles; Kynurenic Acid; Maternal Deprivation; Mephenesin; Piperidines; Quinolizines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin Antagonists; Spiro Compounds; Valine; Vocalization, Animal | 1991 |
Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors.
Topics: Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; In Vitro Techniques; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Thalamus; Valine | 1991 |
Effects of MK-801, a non-competitive NMDA antagonist, on linguopharyngeal events in rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Female; Motor Activity; N-Methylaspartate; Nystagmus, Physiologic; Pharynx; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Tongue | 1991 |
Regulation of CCK release in cerebral cortex by N-methyl-D-aspartate receptors: sensitivity to APV, MK-801, kynurenate, magnesium and zinc ions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Potassium; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sincalide; Zinc | 1991 |
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; Alanine Transaminase; Animals; Calcium; Dizocilpine Maleate; Glutamates; Glutamic Acid; HIV Envelope Protein gp120; N-Methylaspartate; Neurotoxins; Osmolar Concentration; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells | 1991 |
Regional alterations in brain amino acids after administration of the N-methyl-D-aspartate receptor antagonists MK-801 and CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding, Competitive; Brain Chemistry; Brain Mapping; Dizocilpine Maleate; Female; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; Glutamates; Glutamic Acid; Glycine; Injections, Spinal; Male; Pain; Peripheral Nerve Injuries; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine | 1991 |
Glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Biguanides; Binding, Competitive; Biogenic Polyamines; Biotransformation; Brain; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Kynurenic Acid; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1991 |
The competitive NMDA antagonist AP5, but not the non-competitive antagonist MK801, induces a delay-related impairment in spatial working memory in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Ventricles; Choice Behavior; Dizocilpine Maleate; Injections, Intraventricular; Male; Memory; N-Methylaspartate; Rats; Rats, Inbred Strains; Reference Values; Space Perception | 1991 |
N-methyl-D-aspartate increases cytoplasmic free calcium in mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chlorides; Cytoplasm; Dizocilpine Maleate; Hippocampus; Magnesium Chloride; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Zinc; Zinc Compounds | 1991 |
Studies on substances that induce long-term potentiation in guinea-pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Fluids; Cerebral Cortex; Dizocilpine Maleate; Electric Stimulation; Electrophoresis, Polyacrylamide Gel; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Membrane Potentials; Molecular Weight; Rabbits; Receptors, N-Methyl-D-Aspartate | 1991 |
Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Culture Media; Dizocilpine Maleate; Fetus; Glucose; Kynurenic Acid; Mice; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Ethanol inhibits the N-methyl-D-aspartate (NMDA)-induced attenuation of the NMDA-evoked noradrenaline release in the rat brain cortex: interaction with NMDA-induced desensitization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Ethanol; In Vitro Techniques; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Tonically rhythmic neurons within a cardiorespiratory region of the nucleus tractus solitarii of the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cardiovascular System; Cobalt; Dizocilpine Maleate; gamma-Aminobutyric Acid; Kynurenine; Male; Medulla Oblongata; Membrane Potentials; N-Methylaspartate; Neurons; Neurons, Afferent; Pressoreceptors; Quisqualic Acid; Rats; Rats, Inbred Strains; Respiratory System; Synapses | 1991 |
Electrophysiological evidence for N-methyl-D-aspartate excitatory amino acid receptors in the rat supraoptic nucleus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Electrophysiology; Hypothalamus; In Vitro Techniques; Male; Membrane Potentials; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Supraoptic Nucleus; Synaptic Transmission | 1991 |
Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cricetinae; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dystonia; Female; Male; Memantine; Mesocricetus; Receptors, N-Methyl-D-Aspartate | 1991 |
N-methyl-D-aspartate receptor-mediated spontaneous activity in cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channels; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1991 |
Polyamine effects upon N-methyl-D-aspartate receptor functioning: differential alteration by glutamate and glycine site antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermidine | 1991 |
Neurotoxic activation of glutamate receptors induces an extended neuronal depolarization in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Brain; Cells, Cultured; Dizocilpine Maleate; Glutamates; Glutamic Acid; Macrophages; Mice; Mice, Inbred ICR; Neuroglia; Neurons; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1991 |
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Homocysteine; Immunohistochemistry; Male; Neuropeptide Y; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Somatostatin; Substance P | 1990 |
Glutamate, kainate and quisqualate enhance GABA-dependent chloride uptake in cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biological Transport; Cerebral Cortex; Chloride Channels; Chlorides; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred Strains; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, GABA-A | 1990 |
L-homocysteate stimulates [3H]MK-801 binding to the phencyclidine recognition site and is thus an agonist for the N-methyl-D-aspartate-operated cation channel.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Homocysteine; In Vitro Techniques; Ion Channels; Kinetics; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism; Stimulation, Chemical | 1990 |
Activation of NMDA receptor-coupled channels suppresses the inhibitory action of adenosine on hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Hippocampus; In Vitro Techniques; Ion Channels; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses | 1990 |
Glutamate-induced increases in intracellular Ca2+ in cultured frog tectal cells mediated by direct activation of NMDA receptor channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Intracellular Membranes; Ion Channels; Kainic Acid; N-Methylaspartate; Quisqualic Acid; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Superior Colliculi | 1991 |
Carbamazepine blocks NMDA-activated currents in cultured spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Carbamazepine; Cells, Cultured; Dizocilpine Maleate; Electrophysiology; Female; Ion Channels; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Phenytoin; Pregnancy; Spinal Cord | 1990 |
Acetylcholine release from the rabbit retina mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Convulsants; Dizocilpine Maleate; Glycine; In Vitro Techniques; Light; Magnesium; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Retina | 1991 |
Competitive (AP7) and non-competitive (MK-801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Autoradiography; Binding, Competitive; Carbon Radioisotopes; Cerebral Cortex; Deoxyglucose; Dizocilpine Maleate; Glucose; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
N-methyl-D-aspartate receptors influence neuronal survival in developing spinal cord cultures.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cell Count; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Ganglia, Spinal; Mice; Mice, Inbred C57BL; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1990 |
A role for N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dizocilpine Maleate; Estradiol; Female; Luteinizing Hormone; Ovariectomy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dibenzocycloheptenes; Dizocilpine Maleate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Time Factors | 1990 |
MK-801 and AP5 impair acquisition, but not retention, of the Morris milk maze.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Male; Memory; Motor Activity; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retention, Psychology | 1990 |
Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chick Embryo; Dibenzocycloheptenes; Dihydroxyphenylalanine; Dizocilpine Maleate; Hippocampus; Huntington Disease; Levodopa; Neurons; Parkinson Disease; Quinoxalines; Receptors, Neurotransmitter; Retina | 1990 |
Selective N-methyl-D-aspartate (NMDA) antagonists increase gastric motility in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autonomic Nervous System; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stomach | 1990 |
Effects of antagonists on N-methyl-D-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Medulla Oblongata; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
A possible role of AA2 excitatory amino acid receptors in the expression of stimulant drug effects.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Amphetamine; Animals; Apomorphine; Behavior, Animal; Central Nervous System Stimulants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glutamates; Mice; Motor Activity; Phencyclidine; Quinoxalines; Receptors, Amino Acid; Receptors, Cell Surface; Stereotyped Behavior | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electric Stimulation; Formaldehyde; Ketamine; Neurons; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1990 |
Veratridine and other depolarizing agents counteract the inhibitory effect of Mg2+ ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amifampridine; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Hydrogen; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Veratridine; Veratrine | 1990 |
Effects of NMDA antagonists on developmental plasticity in kitten visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics; Animals; Animals, Newborn; Cats; Cerebral Cortex; Dizocilpine Maleate; Injections; Ketamine; N-Methylaspartate; Neuronal Plasticity; Visual Cortex | 1990 |
Phencyclidine and related compounds evoked [3H]dopamine release from rat mesencephalic cell cultures by a mechanism independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding Sites; Cells, Cultured; Dioxolanes; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Guanidines; Mesencephalon; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Sigma Factor; Tritium | 1990 |
NMDA antagonists prevent hypothermic injury and death of mammalian spinal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Dizocilpine Maleate; Female; Freezing; Hypothermia, Induced; Ketamine; Mice; N-Methylaspartate; Neurons; Pregnancy; Spinal Cord Injuries | 1990 |
N-methyl-D-aspartate, kainate and quisqualate release endogenous adenosine from rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adenosine; Animals; Calcium; Cerebral Cortex; Dipeptides; Dizocilpine Maleate; In Vitro Techniques; Kainic Acid; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices.
Topics: Animals; Aspartic Acid; Calcineurin; Calmodulin-Binding Proteins; Colforsin; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; N-Methylaspartate; Nerve Tissue Proteins; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphothreonine; Protein Kinases; Protein Phosphatase 1; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Fever; Phenotype; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Synaptic Membranes | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Dose-Response Relationship, Drug; Imipramine; Immobilization; Male; Mice; Mice, Inbred C57BL; Motor Activity; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stress, Psychological; Strychnine; Swimming; Synaptic Transmission | 1990 |
Dibenzocycloalkenimine (MK-801) stimulates phosphoinositide hydrolysis in rat cerebral cortical slices).
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atropine; Cerebral Cortex; Dizocilpine Maleate; Hydrolysis; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Phencyclidine; Phosphatidylinositols; Prazosin; Rats; Rats, Inbred Strains; Zinc | 1990 |
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Striatum; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Huntington Disease; Ketamine; Male; Neuropeptide Y; Nimodipine; Peptides; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substance P; Taurine; Valine | 1988 |
Biexponential kinetics of [3H]MK-801 binding: evidence for access to closed and open N-methyl-D-aspartate receptor channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glycine; In Vitro Techniques; Ion Channels; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptosomes; Valine | 1989 |
NMDA receptor antagonists can enhance or impair learning performance in animals.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gerbillinae; Male; Memory; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Involvement of N-methyl-D-aspartate (NMDA) receptors in respiratory rhythmogenesis.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Brain; Cats; Dibenzocycloheptenes; Dizocilpine Maleate; Phrenic Nerve; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Respiration; Vagus Nerve | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; N-Methylaspartate; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Valine | 1989 |
Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding Sites; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Kynurenic Acid; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Subcellular Fractions; Valine | 1989 |
Subchronic administration of MK-801 in the rat decreases cortical binding of [3H]D-AP5, suggesting down-regulation of the cortical N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Tolerance; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
NMDA receptor antagonists disrupt the retinotectal topographic map.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anura; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi | 1989 |
Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Choline; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Homocysteine; Interneurons; Magnesium; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Tachyphylaxis; Tiletamine | 1988 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
The pharmacological selectivity of three NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hexamethonium Compounds; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Norepinephrine; Piperazines; Rats; Serotonin; Synaptic Transmission; Valine | 1988 |
Possible role of excitatory amino acids in the convulsant action of catechol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Catechols; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electromyography; Female; Pipecolic Acids; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Seizures; Valine | 1988 |
Mode of binding of [3H]dibenzocycloalkenimine (MK-801) to the N-methyl-D-aspartate (NMDA) receptor and its therapeutic implication.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety Agents; Benzodiazepines; Diltiazem; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nifedipine; Pipecolic Acids; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Stimulation of adenosine A2a receptors in the rat striatum induces catalepsy that is reversed by antagonists of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Anticonvulsants; Catalepsy; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Globus Pallidus; Male; Neural Pathways; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1995 |
Single-channel activity in cultured cortical neurons of the rat in the presence of a toxic dose of glutamate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bradykinin; Calcium; Cells, Cultured; Cerebral Cortex; Chloride Channels; Dizocilpine Maleate; Electrophysiology; Extracellular Space; Glutamates; Glutamic Acid; Ion Channels; Mice; Neurons; Potassium Channels; Rats | 1993 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Cloning, Molecular; Dizocilpine Maleate; DNA; Glutamic Acid; Ion Channels; Kinetics; Kynurenic Acid; Ligands; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1994 |
Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Ion Channels; Ligands; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; N-Methylaspartate; Neuropeptides; Neurotoxins; Oligopeptides; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Potentiation by calcium ions of [3H]MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Ion Channels; Kynurenic Acid; Male; Phospholipases; Phospholipases A; Protein Binding; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1995 |
N-methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Intrathecal administration of N-methyl-D-aspartate receptor antagonist reduces the minimum alveolar anaesthetic concentration of isoflurane in rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Inhalation; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Isoflurane; Male; N-Methylaspartate; Pulmonary Alveoli; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1995 |
Excitatory amino acid antagonists attenuate the effects of cocaine on extracellular dopamine in the nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Dizocilpine Maleate; Dopamine; Drug Interactions; Excitatory Amino Acids; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1995 |
The competitive NMDA antagonists CGP 43487 and APV potentiate dopaminergic function.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Locomotion; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 1995 |
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Brain; Chromosome Mapping; Chromosomes, Human, Pair 9; Cricetinae; Dizocilpine Maleate; DNA; Humans; Hybrid Cells; Karyotyping; Kynurenic Acid; Macromolecular Substances; Magnesium; Molecular Sequence Data; N-Methylaspartate; Oocytes; Poly A; Receptors, N-Methyl-D-Aspartate; RNA; RNA, Messenger; Temporal Lobe; Xenopus; Zinc | 1993 |
Glutamate receptor agonists enhance the expression of BDNF mRNA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Kynurenic Acid; Molecular Weight; N-Methylaspartate; Nerve Growth Factors; Nerve Tissue Proteins; Quinoxalines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Tetrodotoxin; Transcription, Genetic | 1993 |
Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Cloning, Molecular; Dizocilpine Maleate; DNA; Female; Frontal Lobe; Gene Library; Glutamates; Glutamic Acid; Glycine; Humans; Ibotenic Acid; Kainic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oocytes; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Xenopus laevis | 1993 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; Hypnotics and Sedatives; Male; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Brain; Cell Death; Cells, Cultured; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; L-Lactate Dehydrogenase; Neurons; Tumor Necrosis Factor-alpha | 1994 |
The utility of excitatory amino acid (EAA) antagonists as analgesic agents. II. Assessment of the antinociceptive activity of combinations of competitive and non-competitive NMDA antagonists with agents acting at allosteric-glycine and polyamine receptor
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Analgesics; Animals; Binding, Competitive; Biogenic Polyamines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Formaldehyde; Pain Measurement; Rats; Receptors, Biogenic Amine; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Changes in prepulse inhibition after local administration of NMDA receptor ligands in the core region of the rat nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Male; N-Methylaspartate; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Regulation of motor neuron dendrite growth by NMDA receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dendrites; Dizocilpine Maleate; Female; Histocytochemistry; Male; Motor Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
Ethanol effects of NMDA-stimulated levels of extracellular neurotransmitters by in vivo microdialysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Ethanol; Extracellular Space; Male; Microdialysis; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
The effects of NMDA receptor antagonists at anticonvulsive doses on the performance of rats in the water maze task.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Electroshock; Learning; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Swimming | 1995 |
Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; In Vitro Techniques; Ionophores; Leucine; Male; Nerve Tissue Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1995 |
Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Cell Division; Cell Survival; Dizocilpine Maleate; DNA; Hippocampus; Homeostasis; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S Phase; Thymidine; Time Factors | 1995 |
Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims.
Topics: 2-Amino-5-phosphonovalerate; Adult; Dizocilpine Maleate; Female; Frontal Lobe; Humans; In Vitro Techniques; Kynurenic Acid; Male; Middle Aged; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Suicide | 1995 |
Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Acetic Acid; Animals; Anticonvulsants; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Formaldehyde; Indoles; Ligands; Male; Mice; Mice, Inbred Strains; Motor Activity; Pain; Propionates; Pyrrolidinones; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Depression; Dizocilpine Maleate; Imipramine; Injections, Intraperitoneal; Male; Models, Biological; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Stress, Physiological | 1994 |
[Ketamine inhibits n-methyl-d-aspartate (NMDA) receptor mediated acetylcholine release from rabbit caudate nucleus slices].
Topics: Acetylcholine; Action Potentials; Amantadine; Animals; Caudate Nucleus; Choline; Dizocilpine Maleate; In Vitro Techniques; Ketamine; Memantine; Rabbits; Receptors, N-Methyl-D-Aspartate; Valine | 1994 |
NMDA-mediated potentiation of the afferent synapse in the inner ear.
Topics: 2-Amino-5-phosphonovalerate; Ambystoma; Amplifiers, Electronic; Animals; Dizocilpine Maleate; Electrophysiology; Glycine; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons, Afferent; Physical Stimulation; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synapses; Vestibule, Labyrinth | 1994 |
Glutamatergic neurons projecting to the nucleus accumbens can affect motor functions in opposite directions depending on the dopaminergic tone.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biogenic Monoamines; Dizocilpine Maleate; Dopamine; Glutamates; Male; Mesencephalon; Mice; Motor Activity; Movement; Neostriatum; Neural Pathways; Neurons; Nucleus Accumbens; Receptors, Dopamine D2; Stereotaxic Techniques; Stereotyped Behavior | 1994 |
Cyanide induces protein kinase C translocation: blockade by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antibodies, Monoclonal; Blotting, Western; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hippocampus; Potassium Cyanide; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Comparison of the effects of NMDA and AMPA antagonists on the locomotor activity induced by selective D1 and D2 dopamine agonists in reserpine-treated mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Phenethylamines; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine | 1994 |
A possible role of glutathione as an endogenous agonist at the N-methyl-D-aspartate recognition domain in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Glutamate Dehydrogenase; Glutamates; Glutathione; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Facilitation of hippocampal potentials by suramin.
Topics: 2-Amino-5-phosphonovalerate; Adenylyl Imidodiphosphate; Animals; Dizocilpine Maleate; Evoked Potentials; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Suramin | 1995 |
NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Dizocilpine Maleate; Glutamates; Homocysteine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
NMDA-receptor antagonists disrupt the formation of the auditory space map in the mammalian superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Auditory Pathways; Dizocilpine Maleate; Ferrets; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Visual Pathways | 1995 |
Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex of rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Benzazepines; Binding, Competitive; Dizocilpine Maleate; Dopamine; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Sulpiride | 1994 |
Synergistic interactions between NMDA-antagonists and L-dopa on activity in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
Volatile anesthetics inhibit NMDA-stimulated 45Ca uptake by rat brain microvesicles.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Calcium; Calcium Radioisotopes; Dizocilpine Maleate; Enflurane; Glycine; Halothane; Kinetics; Male; Microcirculation; N-Methylaspartate; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Pipecolic Acids; Piperazines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 1994 |
Dendritic Ca2+ accumulations and metabotropic glutamate receptor activation associated with an N-methyl-D-aspartate receptor-independent long-term potentiation in hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium; Dendrites; Dizocilpine Maleate; Guinea Pigs; Hippocampus; Long-Term Potentiation; Neurons; Nimodipine; Potassium Channels; Protein Kinase C; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetraethylammonium; Tetraethylammonium Compounds | 1994 |
Effects of antagonists at the NMDA receptor complex in two models of anxiety.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Dizocilpine Maleate; Drinking; Electroshock; Exploratory Behavior; Injections, Intraventricular; Kynurenic Acid; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Aspirin; Binding, Competitive; Disease; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Regulation of dopamine levels in intrastriatal grafts of fetal mesencephalic cell suspension: an in vivo voltammetric approach.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Benzazepines; Brain Tissue Transplantation; Cerebral Ventricles; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Female; Fetal Tissue Transplantation; Glutamic Acid; Injections, Intraventricular; Kinetics; Mesencephalon; N-Methylaspartate; Oxidopamine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Dopamine D1; Sulpiride; Time Factors; Transplantation, Heterotopic | 1994 |
Effect of systemic administration of N-methyl-D-aspartic acid on extracellular taurine level measured by microdialysis in the hippocampal CA1 field and striatum of rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dizocilpine Maleate; Extracellular Space; Hippocampus; Injections, Intraperitoneal; Kinetics; Male; Microdialysis; N-Methylaspartate; Pyramidal Tracts; Rats; Rats, Wistar; Taurine; Time Factors | 1993 |
Further evidence for multiple forms of an N-methyl-D-aspartate recognition domain in rat brain using membrane binding techniques.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Brain; Dithionitrobenzoic Acid; Dizocilpine Maleate; Ethylmaleimide; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Reagents; Synaptic Membranes | 1993 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-D-aspartate receptor antagonist, MK-801.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trypsin | 1993 |
Potent analgesia induced in rats by combined action at PCP and polyamine recognition sites of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Drug Combinations; Drug Synergism; Glycine; Injections, Spinal; Male; Nociceptors; Phencyclidine; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine | 1993 |
Synaptic excitation triggers oscillations during NMDA receptor activation in rat abducens motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Abducens Nerve; Animals; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Ketamine; Male; Motor Neurons; N-Methylaspartate; Oscillometry; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Involvement of amygdala N-methyl-D-asparate receptors in long-term retention of an inhibitory avoidance response in rats.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Amygdala; Animals; Avoidance Learning; Dizocilpine Maleate; Long-Term Potentiation; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retention, Psychology | 1993 |
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Biogenic Monoamines; Brain; Dizocilpine Maleate; Female; Motor Activity; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1993 |
Low doses of NMDA receptor antagonists synergistically increase the anticonvulsant effect of the AMPA receptor antagonist NBQX in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Epilepsies, Partial; Female; Kindling, Neurologic; Motor Activity; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1993 |
3-Nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Neurons; Neurotoxins; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Freund's Adjuvant; Inflammation; Injections, Spinal; Male; Mechanoreceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Grooming; Limbic System; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Pilocarpine; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Modulation of muscarinic cholinoceptor-stimulated inositol 1,4,5-trisphosphate accumulation by N-methyl-D-aspartate in neonatal rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Dizocilpine Maleate; Female; Glycine; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Magnesium; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Muscarinic | 1994 |
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Dizocilpine Maleate; In Vitro Techniques; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1994 |
Glutamate as a neuron-to-glial signal for mitogenesis: role of glial N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Aged; Aged, 80 and over; Cell Division; Cells, Cultured; Dizocilpine Maleate; DNA; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Humans; Middle Aged; N-Methylaspartate; Neuroglia; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction | 1993 |
Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: memory impairments depend on familiarity with the environment, drug dose, and training duration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arousal; Brain Mapping; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Habituation, Psychophysiologic; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Mental Recall; Motor Activity; Orientation; Rats; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Social Environment; Space Perception | 1994 |
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Brain; Dizocilpine Maleate; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Nerve Degeneration; Nerve Regeneration; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thymidine; Vimentin | 1994 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; Hippocampus; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1994 |
Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Brain; Cell Membrane; Dextroamphetamine; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Ketamine; Male; Pargyline; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Selegiline; Synaptic Membranes | 1994 |
Evidence that arcaine increases the N-methyl-D-aspartate-induced cardiovascular effects into the periaqueductal gray area of anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Biguanides; Blood Pressure; Dizocilpine Maleate; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Male; N-Methylaspartate; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
NMDA antagonists increase recovery of evoked potentials from slices of rat olfactory cortex after anoxia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Hypoxia; Dizocilpine Maleate; Evoked Potentials; Female; In Vitro Techniques; Ketamine; N-Methylaspartate; Olfactory Pathways; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Female; Hydrolysis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; N-Methylaspartate; Neurotoxins; Phosphatidylinositols; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Binding, Competitive; Cell Survival; Cells, Cultured; Cerebral Cortex; Dendrites; Dizocilpine Maleate; Embryo, Mammalian; Glutamates; Glutamic Acid; N-Methylaspartate; Neurons; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Involvement of pontile NMDA receptors in inspiratory termination in rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Male; Pons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Respiration | 1994 |
NMDA receptor function is enhanced in the hippocampus of aged rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Tritium | 1994 |
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Newborn; Aspartic Acid; Benzamides; Benzazepines; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Motor Activity; Nutrition Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1994 |
Sigma-receptor regulation of [3H]arachidonic acid release from rat neonatal cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Arachidonic Acid; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Haloperidol; Kinetics; Melitten; N-Methylaspartate; Neurons; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Morphine physical dependence intensification by hypoglycemia: NMDA receptor involvement.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain; Dizocilpine Maleate; Hypoglycemia; Insulin; Male; Morphine Dependence; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1994 |
Both NMDA and non-NMDA receptors in the NTS participate in the baroreceptor reflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baroreflex; Blood Pressure; Dizocilpine Maleate; Drug Interactions; Functional Laterality; Heart Rate; Male; Microinjections; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus | 1994 |
N-methyl-D-aspartate receptor blockade impairs behavioural performance of rats in a reaction time task: new evidence for glutamatergic-dopaminergic interactions in the striatum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Male; Microinjections; Neostriatum; Raclopride; Rats; Rats, Wistar; Reaction Time; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Salicylamides; Synaptic Transmission | 1994 |
Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amantadine; Amino Acids; Animals; Anticonvulsants; Catalepsy; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Ergolines; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperazines; Quinpirole; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1994 |
Injections of excitatory amino acid antagonists into the median raphe nucleus produce hippocampal theta rhythm in the urethane-anesthetized rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Anesthesia; Animals; Anticonvulsants; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections; Kainic Acid; Male; Quisqualic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Theta Rhythm; Urethane | 1994 |
Functional interactions between glutamate and dopamine in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Conditioning, Psychological; Corpus Striatum; Dizocilpine Maleate; Dopamine; Glutamic Acid; Kinetics; Male; Microinjections; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Dizocilpine Maleate; Estradiol; Female; Hippocampus; Ovariectomy; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1994 |
Hypotension to central endothelin-1: effect of glutamate receptor blockade.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Endothelins; Excitatory Amino Acid Antagonists; Hypotension; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1994 |
In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Body Weight; Dizocilpine Maleate; Electrocardiography; Electroencephalography; Electrolytes; Magnesium Deficiency; Male; Noise; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aged; Amino Acids; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Humans; Middle Aged; Motor Neurons; Nerve Degeneration; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
Long-term potentiation in hippocampal CA1: effects of afterdischarges, NMDA antagonists, and anticonvulsants.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electrophysiology; Hippocampus; Male; N-Methylaspartate; Phenytoin; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Synapses | 1993 |
Effects of NMDA receptor antagonists in squirrel monkeys trained to discriminate the competitive NMDA receptor antagonist NPC 12626 from saline.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Discrimination Learning; Dizocilpine Maleate; Male; Piperazines; Receptors, N-Methyl-D-Aspartate; Saimiri | 1993 |
Long-term potentiation in the avian hippocampus does not require activation of the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Columbidae; Dizocilpine Maleate; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
L-beta-methylamino-alanine-induced behavioral changes in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids, Diamino; Animals; Behavior, Animal; Cyanobacteria Toxins; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electroencephalography; Injections, Intraventricular; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Base Sequence; Blotting, Northern; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; Molecular Sequence Data; Neurons; Neurotoxins; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Strychnine; Time Factors | 1993 |
Modulation of neuronal migration by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Calcium; Cell Movement; Cerebellum; Dizocilpine Maleate; Egtazic Acid; Glutamates; Glutamic Acid; Glycine; Magnesium; Mice; N-Methylaspartate; Neurons; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1993 |
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Brain; Dizocilpine Maleate; Drug Administration Schedule; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1993 |
Phosphatidylserine increases hippocampal synaptic efficacy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Male; Phosphatidylserines; Rats; Synapses; Synaptic Transmission | 1993 |
Purkinje cell survival is differentially regulated by metabotropic and ionotropic excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Cell Survival; Cells, Cultured; Cyclopentanes; Dizocilpine Maleate; Embryo, Mammalian; gamma-Aminobutyric Acid; Kinetics; Purkinje Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
Isolation and characterization of histogranin, a natural peptide with NMDA receptor antagonist activity.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Medulla; Amino Acid Sequence; Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Molecular Sequence Data; Pentazocine; Proteins; Radioimmunoassay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Tissue Distribution | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Epilepsy; Female; Lamotrigine; Male; Motor Activity; Phenytoin; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Triazines | 1993 |
Spermidine and cardiovascular control in nucleus tractus solitarii in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular System; Dizocilpine Maleate; Dose-Response Relationship, Drug; Heart Rate; Male; Methylene Blue; Microinjections; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Spermidine | 1993 |
Structural, neurochemical and behavioural consequences of neonatal blockade of NMDA receptor through chronic treatment with CGP 39551 or MK-801.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Choline O-Acetyltransferase; Dizocilpine Maleate; Female; Motor Activity; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Male; Microdialysis; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Tetrodotoxin | 1994 |
gamma-Acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminobutyrate Transaminase; Alkynes; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Axons; Choline O-Acetyltransferase; Dizocilpine Maleate; Hippocampus; In Vitro Techniques; Kynurenic Acid; Lyases; Male; Nerve Degeneration; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Transaminases | 1993 |
Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Maleate; Electrocardiography; Electroencephalography; Male; Putrescine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Manufacture and release characteristics of Elvax polymers containing glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Drug Carriers; Drug Implants; Excitatory Amino Acid Antagonists; Ferrets; Molecular Weight; N-Methylaspartate; Piperazines; Polyvinyls; Receptors, Glutamate | 1995 |
Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells.
Topics: 2-Amino-5-phosphonovalerate; Cell Death; Cellular Senescence; Dizocilpine Maleate; Glutamic Acid; Humans; Neurons; Neurotoxins; Nitric Oxide; Receptors, N-Methyl-D-Aspartate; Teratocarcinoma; Tumor Cells, Cultured | 1995 |
Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Animals; Binding Sites; Blotting, Northern; Cell Line; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression; Glutamine; Glycine; Humans; Mice; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Tritium | 1996 |
Tolerance to ketamine-induced blockade of cortical spreading depression transfers to MK-801 but not to AP5 in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cortical Spreading Depression; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Ketamine; Male; Microinjections; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1995 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biogenic Monoamines; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; N-Methylscopolamine; Nordefrin; Nucleus Accumbens; Parasympatholytics; Scopolamine Derivatives; Stereotyped Behavior | 1995 |
Weaver granule neurons are rescued by calcium channel antagonists and antibodies against a neurite outgrowth domain of the B2 chain of laminin.
Topics: Animals; Antibodies, Monoclonal; Calcium Channel Blockers; Cell Movement; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Laminin; Leukocyte L1 Antigen Complex; Mice; Mice, Mutant Strains; Neural Cell Adhesion Molecules; Neurites; Neurons; omega-Conotoxin GVIA; Peptides; Rabbits; Receptors, N-Methyl-D-Aspartate; Valine; Verapamil | 1996 |
Morphine-induced catalepsy is augmented by NMDA receptor antagonists, but is partially attenuated by an AMPA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Benzodiazepines; Catalepsy; Dizocilpine Maleate; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Benzothiadiazines; Cell Line; Cell Survival; Concanavalin A; Dizocilpine Maleate; DNA Primers; Evoked Potentials; Glutamic Acid; Humans; Ion Channels; Kainic Acid; Kidney; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Transfection | 1996 |
Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Progesterone in vitro increases NMDA-evoked [3H] dopamine release from striatal slices in proestrus rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Corpus Striatum; Dizocilpine Maleate; Dopamine; Drug Synergism; Estrus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; N-Methylaspartate; Progesterone; Rats; Rats, Sprague-Dawley; Tritium | 1996 |
Effects of glutamate receptor antagonists on posthypoxic myoclonus in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hypoxia, Brain; Male; Myoclonus; Quinoxalines; Rats; Rats, Sprague-Dawley | 1996 |
The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Benzazepines; Binding, Competitive; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Down-Regulation; Excitatory Amino Acid Antagonists; Homovanillic Acid; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission; Ventral Tegmental Area | 1996 |
Effect of NMDA receptor antagonists on D1, D2 and D1/D2 mediated behaviors in intact rats.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
CNQX prevents spinal motor neuron death following sciatic nerve transection in newborn rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Motor Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord | 1995 |
NMDA-receptor modulation of lateral inhibition and c-fos expression in olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; Ketamine; Male; Neural Inhibition; Olfactory Bulb; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1996 |
Excitatory amino acid antagonists in the rostral ventromedial medulla inhibit mesencephalic morphine analgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analgesics, Opioid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections; Male; Medulla Oblongata; Mesencephalon; Morphine; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1996 |
Competitive NMDA receptor antagonists do not produce locomotor hyperactivity by a dopamine-dependent mechanism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Hyperkinesis; Injections; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques | 1995 |
Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.
Topics: 2-Amino-5-phosphonovalerate; Dizocilpine Maleate; Excitatory Amino Acid Agonists; HIV Envelope Protein gp120; HIV-1; Humans; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Tumor Cells, Cultured | 1996 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Electroencephalography; Injections, Intraventricular; Male; Motor Cortex; Neuroprotective Agents; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotaxic Techniques | 1996 |
Effects of NMDA receptor antagonists on inhibition of morphine tolerance in rats: binding at mu-opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord | 1996 |
The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catalepsy; Dizocilpine Maleate; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Theophylline | 1996 |
[The influence of intrathecal NMDA receptor antagonist on the isoflurane MAC and on the motor function].
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoflurane; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1996 |
The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Behavior, Animal; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Time Factors | 1996 |
Discriminative stimulus effects of the NMDA receptor antagonists MK-801 and CGP 37849 in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cues; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Generalization, Stimulus; Male; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Agents | 1996 |
NMDA antagonist blockade of AT8 tau immunoreactive changes in neuronal cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fetus; Fluorescent Antibody Technique; Kynurenic Acid; Microscopy, Confocal; Neurons; Piperidines; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; tau Proteins | 1996 |
Competitive and non-competitive NMDA receptor antagonists induce c-Fos expression in the rat anterior, cingulate cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antibodies; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Genes, fos; Gyrus Cinguli; Male; Neurons; Nuclear Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
NMDA receptor antagonists increase the release of dopamine in the substantia nigra of reserpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dizocilpine Maleate; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Methyltyrosines; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reserpine; Substantia Nigra; Tyrosine 3-Monooxygenase | 1996 |
Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Astrocytes; Biological Transport; Biomarkers; Cell Death; Cells, Cultured; Dizocilpine Maleate; Drug Synergism; Enzyme Induction; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; L-Lactate Dehydrogenase; Models, Biological; N-Methylaspartate; Nerve Tissue Proteins; Neuroglia; Neurons; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Sialoglycoproteins; Tumor Necrosis Factor-alpha | 1995 |
Effects of NMDA receptor blockade in the developing rat somatosensory cortex on the expression of the glia-derived extracellular matrix glycoprotein tenascin-C.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Mapping; Cell Differentiation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycoproteins; Nerve Tissue Proteins; Neuroglia; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Tenascin; Thalamus | 1996 |
Tonic facilitation of glutamate release by presynaptic N-methyl-D-aspartate autoreceptors in the entorhinal cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Electrophysiology; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1996 |
Role of excitatory amino acid receptors in cardiorespiratory coupling in ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Excitatory Amino Acids; Heart; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Respiration | 1996 |
Competitive NMDA receptor antagonist, CGP 40116, substitutes for the discriminative stimulus effects of ethanol.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1996 |
L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Culture Media; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Mesencephalon; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Neuroprotective Agents; Pargyline; Rats; Receptors, Glutamate; Selegiline | 1997 |
Differential effects of agents acting at various sites of the NMDA receptor complex in a place preference conditioning model.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Formaldehyde; Hyperalgesia; Injections, Spinal; Ketamine; Male; Memantine; Morphine; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerves; Touch | 1997 |
Modulation of the NMDA receptor by cyanide: enhancement of receptor-mediated responses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Cerebellum; Cyanides; Cytoplasmic Granules; Diltiazem; Dizocilpine Maleate; Magnesium; Membrane Potentials; N-Methylaspartate; Nifedipine; Patch-Clamp Techniques; Potassium; Rats; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1997 |
Involvement of the NMDA receptor in a non-cholinergic action of acetylcholinesterase in guinea-pig substantia nigra pars compacta neurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholinesterase; Animals; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Guinea Pigs; Humans; In Vitro Techniques; Neurons; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Substantia Nigra; Tolbutamide | 1996 |
Chronic pre-explant blockade of the NMDA receptor affects survival of cerebellar granule cells explanted in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Apoptosis; Cell Survival; Cellular Senescence; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Neuroprotective Agents; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Spinal muscarinic, glutamatergic and GABAergic receptor systems in cardiovascular regulation.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Baclofen; Blood Pressure; Carbachol; Dizocilpine Maleate; Heart Rate; Male; Rats; Rats, Wistar; Receptors, GABA; Receptors, Glutamate; Receptors, Muscarinic; Spinal Cord | 1997 |
Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Appetitive Behavior; Autoradiography; Brain; Brain Mapping; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Lead Poisoning; Male; Mental Recall; N-Methylaspartate; Organometallic Compounds; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
NMDA receptor dependence of the input specific NMDA receptor-independent LTP in the hippocampal CA1 region.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium Channel Blockers; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Nifedipine; Receptors, N-Methyl-D-Aspartate | 1997 |
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; Animals; Cells, Cultured; Cerebral Cortex; Child; Dizocilpine Maleate; Embryo, Mammalian; Evoked Potentials; Glycine; Homocysteine; Humans; Kinetics; Kynurenic Acid; N-Methylaspartate; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Effects of depolarization and NMDA antagonists on the role survival of cerebellar granule cells: a pivotal role for protein kinase C isoforms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Immunoblotting; Isoenzymes; Membrane Potentials; Neurons; Neuroprotective Agents; Potassium; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Glycine causes increased excitability and neurotoxicity by activation of NMDA receptors in the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Benzoxazines; Cell Death; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Neurons; Neurotoxins; Organ Culture Techniques; Oxazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Calcium-dependent, sustained enhancement of excitability during washout of aconitine in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Veratridine | 1997 |
The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exocytosis; GTP-Binding Proteins; In Vitro Techniques; Membrane Fusion; Mice; Mice, Knockout; Neurotransmitter Agents; Patch-Clamp Techniques; Pyramidal Cells; rab3 GTP-Binding Proteins; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Membranes; Synaptic Transmission; Synaptic Vesicles | 1997 |
Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ion Channel Gating; Lysophospholipids; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Glutamate; Valine | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Dizocilpine Maleate; Elapid Venoms; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neurotoxins; Neurotransmitter Agents; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Comparing long-term depression with pharmacologically induced synaptic attenuations in young rat hippocampi.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Kynurenic Acid; Male; Neuronal Plasticity; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Synapses | 1997 |
Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Homocysteine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Memantine; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
The behavioral effects of NMDA antagonists in serotonin depleted rats.
Topics: 2-Amino-5-phosphonovalerate; 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Conflict, Psychological; Dizocilpine Maleate; Drinking Behavior; Excitatory Amino Acid Antagonists; Male; Pain Threshold; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Agents | 1997 |
Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Ketamine; Male; Mice; Morphine; Morphine Dependence; Pain Measurement; Substance Withdrawal Syndrome | 1997 |
The estimation of interactions between arginine-vasopressin (AVP) and NMDA receptors in memory and learning processes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Biguanides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Learning; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Equilin, a principal component of the estrogen replacement therapy premarin, increases the growth of cortical neurons via an NMDA receptor-dependent mechanism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Cognition; Culture Media, Serum-Free; Dizocilpine Maleate; Equilin; Estradiol; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Excitatory Amino Acid Antagonists; Growth Substances; Microscopy, Video; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
Nonopioid motor effects of dynorphin A and related peptides: structure dependence and role of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Male; Mice; Molecular Sequence Data; Motor Activity; Narcotics; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1997 |
Distinct effects of MK-801 and (+/-)-2-amino-5-phosphonopentanoic acid on N-methyl-D-aspartate-induced rise of brain temperature in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum | 1997 |
Effects of competitive and non-competitive NMDA receptor antagonists on behavioral responses induced by 7-OH-DPAT and quinpirole in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Male; Motor Activity; Neostriatum; Nucleus Accumbens; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spiperone; Tetrahydronaphthalenes | 1997 |
NMDA receptor binding in adult rat brain after several chronic ethanol treatment protocols.
Topics: 2-Amino-5-phosphonovalerate; Alcoholism; Animals; Binding, Competitive; Brain; Brain Mapping; Dizocilpine Maleate; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Interactions of ethanol with nicotine, dizocilpine, CGP 40116, and 1-(m-chlorophenyl)-biguanide in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Biguanides; Central Nervous System Depressants; Dizocilpine Maleate; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Male; Mice; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Spinal Cord; Tritium | 1998 |
Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding, Competitive; Cocaine; Discrimination Learning; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Magnesium Chloride; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1998 |
Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Motor Activity; NG-Nitroarginine Methyl Ester; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1998 |
Manipulations of glutamatergic (N-methyl-D-aspartate receptor) neurotransmission alter the rate of photoperiodically regulated sexual maturation in the male Siberian hamster.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cricetinae; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Gonadotropin-Releasing Hormone; Male; N-Methylaspartate; Phodopus; Photoperiod; Receptors, N-Methyl-D-Aspartate; Sexual Maturation; Synaptic Transmission; Testis | 1998 |
Evidence for postsynaptic induction and expression of NMDA receptor independent LTP.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Axons; Dizocilpine Maleate; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Male; Membrane Potentials; Models, Neurological; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Synapses | 1998 |
Efficacy of glutamate receptor antagonists in the management of functional disorders in cytotoxic brain oedema induced by hexachlorophene.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Brain Edema; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hexachlorophene; Male; Rats; Rats, Wistar; Receptors, Glutamate | 1998 |
Stimulation-induced responses of the trigeminal caudal neurons in the brainstem preparation isolated from newborn rats.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Aging; Animals; Animals, Newborn; Bicuculline; Brain Mapping; Brain Stem; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Functional Laterality; In Vitro Techniques; Magnesium; Mandibular Nerve; Medulla Oblongata; Neuronal Plasticity; Neurons; Rats; Reaction Time; Trigeminal Nerve | 1998 |
Spinal NMDA receptor involvement in expansion of dorsal horn neuronal receptive field area produced by intracutaneous histamine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Histamine; Injections, Intradermal; Male; Microinjections; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensory Receptor Cells; Spinal Cord | 1998 |
Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bicuculline; Calcium; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Fetus; Glycine; Humans; Mice; N-Methylaspartate; Neocortex; Neurites; Neurons; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Steroid 17-alpha-Hydroxylase | 1998 |
Glutamate receptors are expressed by bone cells and are involved in bone resorption.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antibodies, Monoclonal; Bone Resorption; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Femur; Osteoblasts; Osteoclasts; Polyglutamic Acid; Rabbits; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1998 |
Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Alanine; Amino Acids; Animals; Biogenic Monoamines; Brain; Carrier Proteins; Consciousness; Corpus Striatum; Dizocilpine Maleate; Dopamine; Glutamates; Hydroxyindoleacetic Acid; Kinetics; Leucine; Male; Norepinephrine; Organ Specificity; Rats; Rats, Wistar; Stereoisomerism; Tea | 1998 |
Suppression of sprouting: An early function of NMDA receptors in the absence of AMPA/kainate receptor activity.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Cells, Cultured; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Magnesium; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Qa-SNARE Proteins; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synapses; Synaptophysin; Synaptosomal-Associated Protein 25; Tetrodotoxin; Xenopus | 1998 |
Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Chemistry; Convulsants; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Inositol Phosphates; Kindling, Neurologic; Male; Neuroprotective Agents; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
NMDA receptor-dependent long term hyperalgesia after tail amputation in mice.
Topics: 2-Amino-5-phosphonovalerate; Amputation, Surgical; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Tail | 1998 |
Characterization of the N-methyl-D-aspartate (NMDA) receptor in the embryonic chick brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Blotting, Western; Brain; Brain Chemistry; Calcium; Cell Count; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Kainic Acid; Neurons; Receptors, N-Methyl-D-Aspartate; Telencephalon | 1998 |
Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Hyperbaric Oxygenation; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Chronic dosing with 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, modulates NMDA inhibition of muscarinic-coupled PI hydrolysis in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Cerebral Cortex; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hydrolysis; In Vitro Techniques; Inositol; Kynurenic Acid; Male; Muscarinic Agonists; N-Methylaspartate; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Magnesium; Male; Neural Inhibition; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Calcium elevation in astrocytes causes an NMDA receptor-dependent increase in the frequency of miniature synaptic currents in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Calcium; Cell Communication; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Neurons; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Effects of systemic, intracerebral, or intrathecal administration of an N-methyl-D-aspartate receptor antagonist on associative morphine analgesic tolerance and hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Analysis of Variance; Animals; Association Learning; Binding, Competitive; Dizocilpine Maleate; Drinking Behavior; Drug Administration Routes; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morphine; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Taste; Thermosensing; Time Factors | 1998 |
Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antimetabolites; Avoidance Learning; Binding, Competitive; Brain Chemistry; Cycloserine; Dizocilpine Maleate; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists; Ligands; Male; Mice; Neurotoxins; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Association between the low threshold calcium spike and activation of NMDA receptors in guinea-pig substantia nigra pars compacta neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium; Differential Threshold; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Guinea Pigs; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 1998 |
VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Astrocytes; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Mice; Neuronal Plasticity; Neurons; Neuropeptides; Neurotransmitter Agents; Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Vasoactive Intestinal Peptide | 1998 |
Duration of NMDA-dependent synaptic potentiation in piriform cortex in vivo is increased after epileptiform bursting.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Long-Term Potentiation; Male; N-Methylaspartate; Neural Inhibition; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Reaction Time; Synapses; Theta Rhythm | 1998 |
Sustained exposure to a glycine receptor partial agonist differentially alters NMDA receptor agonist and antagonist potencies in cultured spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Embryo, Mammalian; Excitatory Amino Acid Agonists; Gene Expression; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord | 1998 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocilpine Maleate; Egtazic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Magnesium; Membrane Potentials; Microscopy, Confocal; Neurons; Nifedipine; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1998 |
A microdialysis study investigating the mechanisms of hydroxyl radical formation in rat striatum exposed to glutamate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Cyclic N-Oxides; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Iron Chelating Agents; Microdialysis; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitrogen Oxides; Quinacrine; Rats; Rats, Sprague-Dawley | 1998 |
Gonadal and age-related influences on NMDA-induced growth hormone secretion in male rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Growth Hormone; Growth Hormone-Releasing Hormone; Male; N-Methylaspartate; Orchiectomy; Periodicity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate; Testis; Testosterone | 1999 |
Low resting potential and postnatal upregulation of NMDA receptors may cause Cajal-Retzius cell death.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adenosine Triphosphate; Aging; Animals; Cell Death; Cerebral Cortex; Dizocilpine Maleate; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Immunohistochemistry; In Vitro Techniques; Meglumine; Membrane Potentials; N-Methylaspartate; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Piperazines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Up-Regulation | 1999 |
Regulation of vasopressin release by ionotropic glutamate receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Hypothalamo-Hypophyseal System; Kainic Acid; N-Methylaspartate; Organ Culture Techniques; Quinoxalines; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Vasopressins | 1998 |
Glutamate receptors in the cingulate cortex, hippocampus, and cerebellar vermis of alcoholics.
Topics: 2-Amino-5-phosphonovalerate; Aged; Alcoholism; Cerebellar Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Middle Aged; Receptors, Glutamate | 1999 |
Cation channel control of neurite morphology.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Cell Polarity; Cell Size; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Membrane Potentials; Neurites; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Spider Venoms; Thy-1 Antigens | 1999 |
The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Enzyme Activation; Estrogens; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Neuroprotective Agents; Protein-Tyrosine Kinases; Rats; Signal Transduction | 1999 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
Inhibiting neuronal migration by blocking NMDA receptors in the embryonic rat cerebral cortex: a tissue culture study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Movement; Cells, Cultured; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Female; Neurons; Pregnancy; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Some interactions of L-DOPA and its related compounds with glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kainic Acid; Levodopa; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Xenopus laevis | 1999 |
Effect of NMDA antagonists on the activity of glutaminase and aspartate aminotransferase in the developing rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Aspartate Aminotransferases; Body Weight; Cell Differentiation; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutaminase; L-Lactate Dehydrogenase; Male; Nerve Fibers; Nerve Tissue Proteins; Neurons; Organ Specificity; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone; Tritium | 1999 |
Actions of NMDA and cholinergic receptor antagonists in the rostral ventromedial medulla upon beta-endorphin analgesia elicited from the ventrolateral periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; beta-Endorphin; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Medulla Oblongata; Muscarinic Antagonists; Nicotinic Antagonists; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1999 |
N-methyl-D-aspartate receptor blockade affects polysialylated neural cell adhesion molecule expression and synaptic density during striatal development.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Corpus Striatum; Dizocilpine Maleate; Gene Expression Regulation, Developmental; Ketamine; Microinjections; Neural Cell Adhesion Molecule L1; Neural Cell Adhesion Molecules; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sialic Acids; Synapses | 1999 |
Excitotoxicity plays a role in the death of tyrosine hydroxylase- immunopositive nigral neurons cultured in serum-free medium.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Cell Death; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Embryo, Mammalian; Flunarizine; Mesencephalon; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1999 |
Blockade of GABAA receptors facilitates induction of NMDA receptor-independent long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Antiparkinson Agents; Differential Threshold; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Sexual Behavior, Animal | 1999 |
Pattern formation by retinal afferents in the ferret lateral geniculate nucleus: developmental segregation and the role of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Axonal Transport; Axons; Dizocilpine Maleate; Ferrets; Geniculate Bodies; Receptors, N-Methyl-D-Aspartate; Retina; Thalamus; Visual Pathways | 1999 |
Apoptotic cell death and caspase-3 activation induced by N-methyl-D-aspartate receptor antagonists and their prevention by insulin-like growth factor I.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Calcium; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dizocilpine Maleate; DNA Fragmentation; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Insulin-Like Growth Factor I; Neurons; Protein Synthesis Inhibitors; Rats; Receptors, N-Methyl-D-Aspartate | 1999 |
Modulation of the mesolimbic dopamine system by glutamate: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homovanillic Acid; Limbic System; Male; Microdialysis; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 1999 |
Site-specific NMDA receptor antagonists produce differential effects on cocaine self-administration in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration | 1999 |
Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cycloheximide; Dentate Gyrus; Dizocilpine Maleate; Electric Stimulation; Entorhinal Cortex; Male; Microtubule-Associated Proteins; Neurons; Perforant Pathway; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Synapses; Transcription, Genetic | 1999 |
N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Blotting, Western; Calcium; Caspase 3; Caspases; Cells, Cultured; Cycloheximide; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Situ Nick-End Labeling; Mice; Microscopy, Electron; Neuroglia; Neurons; Potassium; Protein Synthesis Inhibitors; Receptors, N-Methyl-D-Aspartate | 1999 |
Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat.
Topics: 2-Amino-5-phosphonovalerate; Astrocytes; Brain; Calcium; Calcium Channel Blockers; Cell Death; Cells, Cultured; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Fetus; Gallic Acid; Gene Products, tat; HIV-1; Humans; Inositol 1,4,5-Trisphosphate; Ketamine; Neurons; Neurotoxins; Pertussis Toxin; Quinoxalines; tat Gene Products, Human Immunodeficiency Virus; Thapsigargin; Video Recording; Virulence Factors, Bordetella | 1999 |
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Behavior, Addictive; Behavior, Animal; Benzazepines; Cocaine; Cocaine-Related Disorders; Dizocilpine Maleate; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamates; Glutamic Acid; Male; Nucleus Accumbens; Procaine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Self Administration; Synaptic Transmission | 1999 |
Prolonged enhancement of AP-1 DNA binding by blockade of glutamate uptake in cultured neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biological Transport; Cells, Cultured; Cerebellum; Dicarboxylic Acids; Dimerization; Dizocilpine Maleate; DNA-Binding Proteins; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transcription Factor AP-1 | 1999 |
High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Kidney; Male; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Time Factors | 1999 |
NMDA receptor-mediated control of GABA release from neurointermediate lobes of female and male rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Estradiol; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Ovariectomy; Pituitary Gland, Posterior; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Pregnancy; Pregnancy, Animal; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Death; Cell Differentiation; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Mice; Mice, Inbred C57BL; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; T-Lymphocytes, Cytotoxic | 1999 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1999 |
Excitatory and inhibitory synaptic inputs shape the discharge pattern of pump neurons of the nucleus tractus solitarii in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclofen; Bicuculline; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Neural Inhibition; Neurons; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Strychnine; Synapses | 1999 |
Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons.
Topics: Analgesics, Opioid; Animals; Calcium; Cell Survival; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Kynurenic Acid; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Neurotoxins; Peptide Fragments; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1999 |
N-methyl-D-aspartate receptor antagonists are less effective in blocking long-term potentiation at apical than basal dendrites in hippocampal CA1 of awake rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Calcium Channel Blockers; Dendrites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Membrane Potentials; Nifedipine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Wakefulness | 1999 |
MK801 increases retinotectal arbor size in developing zebrafish without affecting kinetics of branch elimination and addition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Dizocilpine Maleate; Kinetics; Larva; Microscopy, Fluorescence; Microscopy, Video; Receptors, N-Methyl-D-Aspartate; Retina; Superior Colliculi; Synaptic Transmission; Vision, Ocular; Visual Pathways; Zebrafish | 2000 |
NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Bicuculline; Calcium; Calcium Channels; Cesium; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 2000 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Energy Metabolism; Epilepsy; Excitatory Amino Acid Antagonists; Glucose; Homocysteine; Injections, Intraventricular; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2000 |
Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Bradykinin; Capsaicin; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Mice, Knockout; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Pain; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substance P | 2000 |
[Effect of the isoosmotic solution with decreased sodium level on mitochondria of cultured granule cells from the cerebellum].
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Cerebellum; Cobalt; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Membrane Potentials; Mitochondria; Neurons; Osmosis; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Solutions; Sucrose | 2000 |
Dantrolene modulates the influence of steady magnetic fields on hippocampal evoked potentials in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Calcium Channels; Dantrolene; Dizocilpine Maleate; Electromagnetic Phenomena; Evoked Potentials; Excitatory Amino Acid Antagonists; Hippocampus; Magnetics; Male; Mice; Mice, Inbred Strains; Muscle Relaxants, Central; Receptors, N-Methyl-D-Aspartate | 2000 |
Brevetoxin-induced autocrine excitotoxicity is associated with manifold routes of Ca2+ influx.
Topics: 2-Amino-5-phosphonovalerate; Aniline Compounds; Animals; Autocrine Communication; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cerebellum; Dextrorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Marine Toxins; Neurons; Neurotoxins; Nifedipine; Oxocins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiourea; Xanthenes | 2000 |
Adenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanism.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; Adrenergic Antagonists; Animals; Caffeine; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; N-Methylaspartate; Neuronal Plasticity; Neurons; Periodicity; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems; Theophylline; Xanthines | 2000 |
The non-competitive NMDA receptor blocker dizocilpine potentiates serotonergic function.
Topics: 2-Amino-5-phosphonovalerate; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Benzazepines; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ketanserin; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sulpiride | 1999 |
Responses to reversible anoxia of intracellular free and bound Ca(2+) in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chlortetracycline; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Hypoxia; In Vitro Techniques; Intracellular Membranes; Olfactory Pathways; Oxygen; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellum; Dicarboxylic Acids; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Nerve Fibers; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2000 |
Cerebral cortical muscarinic cholinergic and N-methyl-D-aspartate receptors mediate increase in cortical blood flow elicited by chemical stimulation of periaqueductal gray matter.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Animals; Blood Pressure; Cerebral Cortex; Cerebrovascular Circulation; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Mecamylamine; Muscarinic Antagonists; N-Methylaspartate; Nicotinic Antagonists; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Scopolamine; Stimulation, Chemical; Vasodilation; Vasodilator Agents | 2000 |
Naltrexone-precipitated morphine withdrawal in infant rat is attenuated by acute administration of NOS inhibitors but not NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Indazoles; Infant, Newborn; Male; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Neonatal Abstinence Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2000 |
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Macaca nemestrina; Neurons; Organ Specificity; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamic Nuclei; Transcription, Genetic; Tritium | 2000 |
Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Benzoates; Dizocilpine Maleate; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Glutamate | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Apparent association of MK-801-sensitive ion channels with L-S-nitrosocysteine recognition sites in the hindlimb vasculature of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cysteine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hindlimb; Ion Channels; Male; N-Methylaspartate; Nitroso Compounds; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Vascular Resistance | 2000 |
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Ischemic Attack, Transient; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Organ Culture Techniques; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Baclofen; Central Nervous System Stimulants; Dextroamphetamine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exploratory Behavior; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Neostriatum; Picrotoxin; Proactive Inhibition; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Stereotyped Behavior; Substantia Nigra | 2000 |
Effects of competitive and non-competitive NMDA receptor antagonists on dopamine output in the shell and core subdivisions of the nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Extracellular Space; Male; Nucleus Accumbens; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2001 |
Glutamate does not play a major role in controlling bone growth.
Topics: 2-Amino-5-phosphonovalerate; Alveolar Bone Loss; Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Biological Transport; Bone Diseases, Metabolic; Bone Remodeling; Bone Resorption; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Femur; Glutamic Acid; Glycine; Humerus; Mandible; Mice; Mice, Knockout; Models, Animal; N-Methylaspartate; Osteoblasts; Osteoclasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Male; Microinjections; N-Methylaspartate; Pentylenetetrazole; Pons; Rats; Rats, Wistar; Reticular Formation; Seizures | 2001 |
Sindbis virus-induced neuronal death is both necrotic and apoptotic and is ameliorated by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Calcium; Cell Death; Cell Line; Cells, Cultured; Cricetinae; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Intracellular Fluid; Necrosis; Neurons; Potassium Channel Blockers; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Sindbis Virus; Tetrodotoxin; Virus Replication | 2001 |
Neither peripheral nerve input nor cortical NMDA receptor activity are necessary for recovery of a disrupted barrel pattern in rat somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Autoradiography; Brain Stem; Carbocyanines; Chromatography, High Pressure Liquid; Clorgyline; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Fluorescent Dyes; Iodine Radioisotopes; Male; Maxillary Nerve; Monoamine Oxidase Inhibitors; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Somatosensory Cortex; Thalamus; Vibrissae | 2001 |
Characterization of ionotropic glutamate receptors in human lymphocytes.
Topics: 2-Amino-5-phosphonovalerate; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies, Monoclonal; Calcium; CD3 Complex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Kainic Acid; Lymphocytes; N-Methylaspartate; Phytohemagglutinins; Quinoxalines; Receptors, Glutamate | 2001 |
Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antidepressive Agents; Bicuculline; Bridged Bicyclo Compounds; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Guinea Pigs; Hippocampus; Hypericum; Organ Culture Techniques; Phloroglucinol; Plant Extracts; Terpenes | 2001 |
Absence of evidence is not evidence of absence. Redundancy blocks determination of cause and effect.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Bone Resorption; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Osteoblasts; Osteogenesis; Receptors, N-Methyl-D-Aspartate | 2001 |
Spinal NMDA receptors contribute to neuronal processing of acute noxious and nonnoxious colorectal stimulation in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catheterization; Colon; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Spinal Cord; Visceral Afferents | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hyperalgesia; Indazoles; Injections, Spinal; Kynurenic Acid; Magnesium Sulfate; Male; Neurons; Nitric Oxide Synthase; Pain Measurement; Phenanthridines; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spine | 2001 |
Effects of N-methyl-D-aspartate agonists and antagonists in rats discriminating amphetamine.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Central Nervous System Stimulants; Cycloserine; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2001 |
Effect of tributyltin on the N-methyl-D-aspartate (NMDA) receptors in the mouse brain.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Body Weight; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Protein Binding; Receptors, N-Methyl-D-Aspartate; Trialkyltin Compounds | 2001 |
Melanin concentrating hormone increase hippocampal synaptic transmission in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Hypothalamic Hormones; Male; Melanins; Neuroprotective Agents; Perfusion; Pituitary Hormones; Rats; Rats, Wistar; Synapses; Time Factors | 2002 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2002 |
The NMDA type glutamate receptors expressed by primary rat osteoblasts have the same electrophysiological characteristics as neuronal receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Femur; Glycine; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Osteoblasts; Patch-Clamp Techniques; Perfusion; Rats; Receptors, N-Methyl-D-Aspartate | 2002 |
Protection of methylmercury effects on the in vivo dopamine release by NMDA receptor antagonists and nitric oxide synthase inhibitors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Methylmercury Compounds; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2002 |
NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Substance Withdrawal Syndrome; Swimming | 2002 |
Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating.
Topics: 2-Amino-5-phosphonovalerate; Binding, Competitive; Cell Line; Dizocilpine Maleate; DNA, Recombinant; Excitatory Amino Acid Antagonists; Genetic Variation; Glutamic Acid; Glycine; Humans; Ion Channel Gating; Nerve Tissue Proteins; Prosencephalon; Receptors, N-Methyl-D-Aspartate | 2002 |
NMDA receptor antagonists attenuate noxious and nonnoxious colorectal distention-induced Fos expression in the spinal cord and the visceromotor reflex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Colon; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rectum; Reflex; Spinal Cord; Visceral Afferents | 2002 |
Blockade of NMDA-receptors or calcium-channels attenuates the ischaemia-evoked efflux of glutamate and phosphoethanolamine and depression of neuronal activity in rat organotypic hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Cell Hypoxia; Deoxyglucose; Diltiazem; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Ischemia; Kinetics; Neurons; Organ Culture Techniques; Phosphatidylethanolamines; Potassium Cyanide; Rats; Receptors, N-Methyl-D-Aspartate | 2002 |
NMDA receptor antagonists impair motor performance in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2002 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Behavior, Animal; Dizocilpine Maleate; Dynorphins; Endorphins; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Spinal; Kynurenic Acid; Male; Mice; Morphine; Neurokinin A; Nociceptors; Peptide Fragments; Piperidines; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2002 |
Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feeding Behavior; Heroin; Injections, Intraventricular; Ketamine; Locomotion; Male; Microinjections; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reinforcement, Psychology; Self Administration; Time Factors; Ventral Tegmental Area | 2002 |
NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Cortex; Colforsin; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Immunohistochemistry; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2002 |
Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclopentanes; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamates; Haloperidol; Neurons; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sodium Azide | 2002 |
Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperalgesia; Inflammation; Injections, Spinal; Male; Motor Activity; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Treatment Outcome; Valine | 2003 |
NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Astrocytes; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Intracellular Membranes; Membrane Potentials; Mitochondria; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Mechanical; Time Factors | 2002 |
Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Hyperalgesia; Male; Nerve Compression Syndromes; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhizotomy | 2003 |
NMDA receptor regulation by amyloid-beta does not account for its inhibition of LTP in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amyloid beta-Peptides; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Colforsin; Culture Techniques; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Immunohistochemistry; Magnesium; Mesencephalon; Neurons; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Time Factors; Tyrosine 3-Monooxygenase | 2003 |
Participation of AMPA- and NMDA-type excitatory amino acid receptors in the spinal reflex transmission, in rat.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Models, Neurological; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex, Monosynaptic; Spinal Cord; Synapses; Time Factors; Valine | 2003 |
Glutamate release in the nucleus accumbens is involved in behavioral depression during the PORSOLT swim test.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; Motor Activity; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Sprague-Dawley; Swimming; Tail; Time Factors; Valine | 2003 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gallic Acid; Guanidines; Indazoles; Injections, Intraperitoneal; Kynurenic Acid; Molsidomine; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII.
Topics: Alanine; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Surface Extensions; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Lysine; Mutation; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Organ Culture Techniques; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Synapses; Synapsins; Synaptic Transmission; Tetrodotoxin; Threonine; Transfection; Valine | 2003 |
Serofendic acid prevents acute glutamate neurotoxicity in cultured cortical neurons.
Topics: Animals; Calcium; Cattle; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine; Diterpenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Combinations; Fetal Blood; Fetus; Ionomycin; Neurons; Neurotoxicity Syndromes; Nitric Oxide; Quinoxalines; Rats; S-Nitrosothiols; Sodium Glutamate; Time Factors; Valine | 2003 |
BDNF sensitizes the response of lamina II neurons to high threshold primary afferent inputs.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Immunohistochemistry; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission; Type C Phospholipases | 2003 |
Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adaptor Proteins, Signal Transducing; Alternative Splicing; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Chlorocebus aethiops; COP-Coated Vesicles; COS Cells; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Exons; GABA Antagonists; Green Fluorescent Proteins; Hippocampus; Immunoblotting; Luminescent Proteins; Membrane Potentials; Models, Biological; Mutation; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Synapses; Tetrodotoxin; Time Factors; Transfection; Valine | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizocilpine Maleate; Drug Therapy, Combination; Injections, Intraventricular; Male; Memory Disorders; Mice; N-Methylaspartate; Olfactory Bulb; Piperidines; Receptors, N-Methyl-D-Aspartate; Spermidine; Time Factors | 2004 |
NMDA receptor antagonists reduce restraint-induced release of prolactin in male rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hypothalamus; Injections, Intraventricular; Male; Prolactin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Stress, Physiological | 2003 |
Frequency-dependent requirement for calcium store-operated mechanisms in induction of homosynaptic long-term depression at hippocampus CA1 synapses.
Topics: Animals; Animals, Newborn; Caffeine; Calcium; Central Nervous System Stimulants; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Indoles; Long-Term Synaptic Depression; Nerve Tissue Proteins; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Ruthenium Red; Ryanodine; Synapses; Thapsigargin; Valine | 2004 |
The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dopamine; Drug Synergism; Male; Microdialysis; Motor Activity; Nicotine; Nucleus Accumbens; Phenols; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Putative NMDA receptors in Hydra: a biochemical and functional study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Cell Membrane; Concanavalin A; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Glutathione; Glycine; Hydra; Kynurenic Acid; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Serine; Strychnine | 2004 |
GluR- and TrkB-mediated maturation of GABA receptor function during the period of eye opening.
Topics: Age Factors; Animals; Animals, Newborn; Blotting, Northern; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; Embryo, Mammalian; Eye; GABA Agonists; Gene Expression Regulation, Developmental; In Vitro Techniques; Mice; Mice, Knockout; N-Methylaspartate; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Receptor, trkB; Receptors, GABA-A; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superior Colliculi; Synapses; Synaptic Transmission; Valine; Zolpidem | 2005 |
Activity-dependent synaptic plasticity in the central nucleus of the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Amygdala; Animals; Chelating Agents; Conditioning, Classical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fear; Guinea Pigs; In Vitro Techniques; Neuronal Plasticity; Patch-Clamp Techniques; Picrotoxin; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic; Thalamus | 2005 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Count; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry; Isoenzymes; Ketamine; Membrane Potentials; N-Methylaspartate; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Statistics, Nonparametric; Synapses; Synaptic Transmission; Synaptophysin; Tetrodotoxin; Time Factors | 2005 |
Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory.
Topics: Animals; Association Learning; Avoidance Learning; Behavior, Animal; Blotting, Western; Brain; Cadmium Chloride; Calcium Channel Blockers; Calcium-Binding Proteins; Choice Behavior; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Discrimination Learning; Dizocilpine Maleate; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Flavonoids; Hippocalcin; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Knockout; Motor Activity; N-Methylaspartate; Nerve Tissue Proteins; Nimodipine; Phosphorylation; Potassium Chloride; Psychomotor Performance; Reaction Time; Rotarod Performance Test; Spatial Behavior; Valine | 2005 |
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading Depression; Dizocilpine Maleate; Electrodes; Excitatory Amino Acid Antagonists; Humans; Ions; Ischemia; Laser-Doppler Flowmetry; Male; Neuroprotective Agents; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Subarachnoid Hemorrhage | 2005 |
Cortical glutamatergic markers in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; In Situ Hybridization; Kainic Acid; Male; Middle Aged; Postmortem Changes; Radioligand Assay; Receptors, Glutamate; Schizophrenia; Tritium | 2005 |
A noncanonical release of GABA and glutamate modulates neuronal migration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Bicuculline; Bromodeoxyuridine; Cell Movement; Dideoxynucleosides; Dizocilpine Maleate; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; In Vitro Techniques; Mice; Mice, Mutant Strains; Mice, Transgenic; Microtubule-Associated Proteins; Munc18 Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2005 |
Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Motor Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2005 |
Blockade of NMDA receptors enhances spontaneous sharp waves in rat hippocampal slices.
Topics: Animals; Apamin; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Scorpion Venoms; Valine | 2005 |
Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Electromyography; Excitatory Amino Acid Antagonists; Facial Pain; Inflammation; Jaw; Male; Muscle, Skeletal; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Temporomandibular Joint; Valine | 2005 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
BDNF stabilizes synapses and maintains the structural complexity of optic axons in vivo.
Topics: Animals; Axons; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; Green Fluorescent Proteins; Larva; Microscopy, Electron, Transmission; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Superior Colliculi; Synapses; Valine; Vesicle-Associated Membrane Protein 2; Xenopus laevis | 2005 |
Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Rats; Rats, Wistar; Synaptic Transmission; Time Factors | 2006 |
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h).
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Blotting, Western; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Cyclic Nucleotide-Gated Cation Channels; Diagnostic Imaging; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Ion Channels; Long-Term Potentiation; Male; Membrane Potentials; Neurons; omega-Conotoxins; Organophosphates; Patch-Clamp Techniques; Potassium Channels; Potassium Chloride; Pyrimidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Statistics, Nonparametric; Tetrodotoxin; Time Factors | 2005 |
Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation.
Topics: 2-Amino-5-phosphonovalerate; Cell Cycle; Cells, Cultured; Dizocilpine Maleate; Humans; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Receptors, Interleukin-2; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes | 2005 |
Consolidation of auditory cortex-dependent memory requires N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Analysis of Variance; Animals; Auditory Cortex; Behavior, Animal; Discrimination Learning; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Gerbillinae; Male; Memory; Receptors, N-Methyl-D-Aspartate | 2006 |
Effect of NMDA antagonists on the death of cerebellar granule neurons at different ages.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; Carbachol; Caspase 3; Caspases; Cells, Cultured; Cerebellum; Cholinergic Agonists; Dizocilpine Maleate; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Valine | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Survival; Cerebral Cortex; Dizocilpine Maleate; DNA Repair Enzymes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Fluorescent Antibody Technique; Gamma Rays; Gene Expression; Histones; Hydrogen Peroxide; MRE11 Homologue Protein; N-Methylaspartate; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2006 |
N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Blotting, Western; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gene Expression; Hippocampus; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Male; Membrane Proteins; Phenols; Piperidines; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Time Factors | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Mediation of glutamatergic receptors and nitric oxide on striatal dopamine release evoked by anatoxin-a. An in vivo microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Cyanobacteria Toxins; Dizocilpine Maleate; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Indazoles; Microcystins; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tropanes | 2006 |
L-type calcium channels and NMDA receptors: a determinant duo for short-term nociceptive plasticity.
Topics: 2-Amino-5-phosphonovalerate; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Animals, Newborn; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Glycine Agents; In Vitro Techniques; Models, Biological; Neuronal Plasticity; Neurons; Nociceptors; Physical Stimulation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Strychnine | 2007 |
Roles of volume-sensitive chloride channel in excitotoxic neuronal injury.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Apoptosis; Benzothiadiazines; Bicuculline; Bumetanide; Cell Size; Cells, Cultured; Cerebral Cortex; Chlorides; Dendrites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glycolates; Ion Channels; Mice; Mice, Inbred C57BL; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Nitrobenzoates; Patch-Clamp Techniques; Phloretin; Picrotoxin; Potassium Channel Blockers; Potassium Channels; Quinine; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors; Sodium Chloride Symporters; Somatosensory Cortex; Tetrodotoxin | 2007 |
Involvement of glutamatergic receptors in the nucleus cuneiformis in modulating morphine-induced antinociception in rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Microinjections; Morphine; Nociceptors; Pain; Quinoxalines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tegmentum Mesencephali | 2007 |
Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Cricetinae; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dystonia; Excitatory Amino Acid Antagonists; Microinjections; Movement; Muscle Contraction; Mutation; Posture; Putamen; Pyrrolidinones; Quinoxalines; Reaction Time; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Valine | 2007 |
Antinociceptive effect of intra-hippocampal CA1 and dentate gyrus injection of MK801 and AP5 in the formalin test in adult male rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Formaldehyde; Hippocampus; Male; Microinjections; Models, Anatomic; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2007 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Spinal; Ion Channels; Kynurenic Acid; Mice; Morphine; Neurokinin A; Nociceptors; Pain; Peptide Fragments; Piperidines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Tachykinin; Substance P | 2007 |
Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Binding, Competitive; Central Nervous System Stimulants; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Male; Methamphetamine; N-Methylaspartate; Neurons; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Protection from inorganic mercury effects on the in vivo dopamine release by ionotropic glutamate receptor antagonists and nitric oxide synthase inhibitors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Anxiety Agents; Anticonvulsants; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Indazoles; Mercuric Chloride; Microdialysis; Neostriatum; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2007 |
D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons.
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Molecular Structure; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Valine | 2007 |
NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Cyclosporine; Dizocilpine Maleate; Magnesium; Male; Mice; Motor Activity; Quinolones; Receptors, N-Methyl-D-Aspartate; Swimming | 2007 |
The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat.
Topics: Age Factors; Animals; Avoidance Learning; Conditioning, Classical; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Freezing Reaction, Cataleptic; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 2007 |
Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels.
Topics: 2-Amino-5-phosphonovalerate; Animals; Base Sequence; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebellum; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cytosol; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Hydrogen Sulfide; Nifedipine; Nimodipine; Rats; Rats, Wistar; RNA, Messenger | 2008 |
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
Topics: 2-Amino-5-phosphonovalerate; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Patch-Clamp Techniques; Phenylcarbamates; Phenytoin; Propylene Glycols; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 2007 |
Recruiting extrasynaptic NMDA receptors augments synaptic signaling.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Dendrites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Neurons; Organic Chemicals; Patch-Clamp Techniques; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetrodotoxin; Valine | 2008 |
NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Cocaine-Related Disorders; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Quinoxalines; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration; Social Environment; Stress, Psychological; Ventral Tegmental Area | 2008 |
Spike timing-dependent long-term depression requires presynaptic NMDA receptors.
Topics: Action Potentials; Animals; Animals, Newborn; Dizocilpine Maleate; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Valine | 2008 |
Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcineurin; Calcium Signaling; Cyclosporine; Dizocilpine Maleate; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Synaptic Depression; Male; Neurons; Okadaic Acid; Patch-Clamp Techniques; Protein Phosphatase 1; Pyramidal Cells; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Tacrolimus | 2008 |
Intra-amygdala and systemic antagonism of NMDA receptors prevents the reconsolidation of drug-associated memory and impairs subsequently both novel and previously acquired drug-seeking behaviors.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Behavior, Addictive; Conditioning, Psychological; Dizocilpine Maleate; Exploratory Behavior; Infusion Pumps; Male; Memory; Rats; Receptors, N-Methyl-D-Aspartate; Self Administration | 2008 |
Modulation of ethanol state-dependent learning by dorsal hippocampal NMDA receptors in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Dizocilpine Maleate; Ethanol; Hippocampus; Learning; Male; Memory; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate | 2008 |
Alternating low frequency stimulation of medial septal and commissural fibers induces NMDA-dependent, long-lasting potentiation of hippocampal synapses in urethane-anesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Male; Mecamylamine; Muscarinic Antagonists; N-Methylaspartate; Nicotinic Antagonists; Rats; Rats, Long-Evans; Scopolamine; Septum of Brain; Synapses; Urethane; Valine | 2009 |
NMDA receptor activation by HIV-Tat protein is clade dependent.
Topics: Amino Acid Motifs; Animals; Antibodies; Cells, Cultured; Cysteine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Humans; Immunoprecipitation; Models, Molecular; Mutagenesis, Site-Directed; Neurons; Nitric Oxide Donors; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; S-Nitrosoglutathione; Serine; tat Gene Products, Human Immunodeficiency Virus; Transfection; Valine | 2008 |
Prenatal ethanol exposure persistently impairs NMDA receptor-dependent activation of extracellular signal-regulated kinase in the mouse dentate gyrus.
Topics: Analysis of Variance; Animals; Butadienes; Dentate Gyrus; Dizocilpine Maleate; Embryo, Mammalian; Enzyme Activation; Ethanol; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Nitriles; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine | 2009 |
Respiratory activity of the neonatal dorsolateral pons in vitro.
Topics: Animals; Animals, Newborn; Bicuculline; Brain Stem; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Functional Laterality; GABA Antagonists; In Vitro Techniques; Membrane Potentials; Models, Biological; Neurons; Patch-Clamp Techniques; Pons; Rats; Respiratory Physiological Phenomena; Respiratory System; Spinal Cord; Valine | 2009 |
Effects of the NMDA receptor antagonists on deltamethrin-induced striatal dopamine release in conscious unrestrained rats.
Topics: Animals; Consciousness; Corpus Striatum; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Insecticides; Male; Nitriles; Pyrethrins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 2009 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermidine; Valine | 2010 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells.
Topics: Active Transport, Cell Nucleus; Apoptosis; Calcium; Calcium Signaling; Cell Line; Cell Nucleus; Dizocilpine Maleate; Hydrolysis; Lanthanum; Nicotiana; Phosphotransferases (Alcohol Group Acceptor); Receptors, N-Methyl-D-Aspartate; Serine C-Palmitoyltransferase; Sphingosine; Valine | 2010 |
Assessment of different induction protocols to elicit long-term depression (LTD) in the rat visual cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics; Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Geniculate Bodies; Glycine; Long-Term Synaptic Depression; Male; N-Methylaspartate; Pentobarbital; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Synaptic Potentials; Urethane; Visual Cortex; Visual Pathways | 2010 |
Opioid-induced long-term potentiation in the spinal cord is a presynaptic event.
Topics: Analgesics, Opioid; Animals; Biophysics; Calcium; Chelating Agents; Diterpenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Egtazic Acid; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Guanosine Diphosphate; In Vitro Techniques; Lectins; Long-Term Potentiation; Male; Neurons; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Cord; Thionucleotides; TRPV Cation Channels; Valine | 2010 |
[Protein synthesis is necessary for induction of amnesia, elicited by disruption of long-term memory reconsolidation].
Topics: Amnesia; Animals; Anisomycin; Cycloheximide; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Helix, Snails; Memory; Protein Biosynthesis; Protein Synthesis Inhibitors; Receptors, N-Methyl-D-Aspartate; Time Factors; Valine | 2010 |
Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catalepsy; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Inferior Colliculi; Male; Microinjections; Motor Activity; N-Methylaspartate; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Synaptic Transmission | 2010 |
The importance of N-methyl-D-aspartate (NMDA) receptors in subtraction of electrosensory reafference in the dorsal nucleus of skates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antibody Specificity; Dizocilpine Maleate; Mass Spectrometry; Microscopy, Confocal; Neurons, Afferent; Neurons, Efferent; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Skates, Fish; Software; Thalamic Nuclei | 2010 |
An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Conditioning, Classical; Cyclopentanes; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mecamylamine; N-Methylaspartate; Nicotine; Phencyclidine; Phenols; Piperazines; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2011 |
Ketamine inhibits tumor necrosis factor secretion by RAW264.7 murine macrophages stimulated with antibiotic-exposed strains of community-associated, methicillin-resistant Staphylococcus aureus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Bacterial Agents; Cell Line; Daptomycin; Dizocilpine Maleate; Drug Synergism; Ketamine; Macrophage Activation; Macrophages; Methicillin-Resistant Staphylococcus aureus; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Time Factors; Tumor Necrosis Factor-alpha; Vancomycin | 2011 |
Amyloid β peptide oligomers directly activate NMDA receptors.
Topics: Amyloid beta-Peptides; Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Electrophysiological Phenomena; Female; Humans; Memantine; Neurons; Oocytes; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Xenopus laevis | 2011 |
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Lidocaine; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Polyamines; Receptors, AMPA; Tetrodotoxin; Valine | 2011 |
Effects of NMDA receptor modulators on a blood-brain barrier in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Blood-Brain Barrier; Blotting, Western; Calcium; Cell Line; Dizocilpine Maleate; Endothelial Cells; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; In Vitro Techniques; Membrane Proteins; Occludin; Phosphoproteins; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Zonula Occludens-1 Protein | 2011 |
Astrocyte signaling controls spike timing-dependent depression at neocortical synapses.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Astrocytes; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Morpholines; Naphthalenes; Neocortex; Patch-Clamp Techniques; Piperidines; Probability; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Thalamus; Time Factors | 2012 |
Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii).
Topics: Analysis of Variance; Animals; Arctic Regions; Arousal; Body Temperature; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Hibernation; Injections, Intraventricular; Oxygen Consumption; Receptors, N-Methyl-D-Aspartate; Sciuridae; Serotonin Antagonists; Tropanes; Valine | 2012 |
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Calcium; Calcium Ionophores; Calpain; Cycloheximide; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Dose-Response Relationship, Drug; Emetine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Ionomycin; K Cl- Cotransporters; Leupeptins; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Statistics, Nonparametric; Symporters; Valine | 2012 |
Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects.
Topics: Animals; Blood Pressure; Bradycardia; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypotension; Male; Nicotine; Nicotinic Agonists; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Solitary Nucleus; Valine | 2012 |
Direct interaction of taurine with the NMDA glutamate receptor subtype via multiple mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Dizocilpine Maleate; Glycine; In Vitro Techniques; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Taurine | 2013 |
Study of the interaction of glutamatergic and nitrergic signalling in conditions of the experimental airways hyperreactivity.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Bronchial Hyperreactivity; Dizocilpine Maleate; Excitatory Amino Acid Agents; Guinea Pigs; Histamine; Male; Muscle, Smooth; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Sodium Glutamate; Trachea | 2013 |
Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.
Topics: Animals; Animals, Newborn; Avoidance Learning; Cognition Disorders; Complement C3; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Net; Neurons; Picrotoxin; Synapses; Ultrasonography; Valine | 2014 |
N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.
Topics: 2-Amino-5-phosphonovalerate; Blood Platelets; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Male; Memantine; P-Selectin; Platelet Activation; Platelet Aggregation; Receptors, N-Methyl-D-Aspartate | 2014 |
Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electroencephalography; Hippocampus; Male; N-Methylaspartate; Orphenadrine; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2014 |
Frequency-specific response facilitation of supra and infragranular barrel cortical neurons depends on NMDA receptor activation in rats.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Muscarinic Antagonists; Neuronal Plasticity; Neurons; Physical Stimulation; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Valine; Vibrissae | 2014 |
A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
Topics: 2-Amino-5-phosphonovalerate; Aniline Compounds; Animals; Astrocytes; Benzimidazoles; Calcium; Calcium Channel Blockers; Carbocyanines; Cells, Cultured; Dizocilpine Maleate; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate Receptors; Ions; Kynurenic Acid; Membrane Potential, Mitochondrial; N-Methylaspartate; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Xanthenes | 2015 |
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Dendritic Spines; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine | 2015 |
Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Glutamic Acid; Injections, Spinal; Male; Mice; Nociception; Pain; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tachykinins | 2016 |
NMDA receptors inhibit axonal outgrowth by inactivating Akt and activating GSK-3β via calcineurin in cultured immature hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcineurin; Calcium; Cations, Divalent; Dizocilpine Maleate; Embryo, Mammalian; Gene Expression Regulation, Developmental; Glycogen Synthase Kinase 3 beta; Hippocampus; Ion Transport; Membrane Glycoproteins; Neuronal Plasticity; Neurons; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2018 |
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Topics: Animals; Astrocytes; CA1 Region, Hippocampal; Cell Count; Cell Death; Cells, Cultured; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Transporter 1; In Vitro Techniques; Lithium Carbonate; Microglia; Ouabain; Rats; Sodium-Potassium-Exchanging ATPase; Valine | 2018 |
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism | 2019 |
Protein synthesis inhibitor administration before a reminder caused recovery from amnesia induced by memory reconsolidation impairment with NMDA glutamate receptor antagonist.
Topics: Amnesia; Animals; Avoidance Learning; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Helix, Snails; Memory Consolidation; Mental Recall; Protein Synthesis Inhibitors; Valine | 2021 |