2-amino-5-phosphonovalerate has been researched along with cgp 39653 in 89 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 67 (75.28) | 18.2507 |
| 2000's | 20 (22.47) | 29.6817 |
| 2010's | 2 (2.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, LM; Jones, TW; Lau, SS; Lee, YH; Leslie, SW; Monks, TJ; Morris, JL; Randall, PK; Trent, RD | 1 |
| Weiland, NG | 1 |
| Halsted, MJ; Hockfield, S; Kalb, RG; Lidow, MS | 1 |
| Costantino, M; Cristina, FM; Cristina, GA; Giovanni, B; Mariangela, S | 1 |
| Angst, C; Brundish, DE; Fagg, G; Hurt, SD; Pozza, M; Sills, MA; Williams, M; Wilusz, EJ | 1 |
| Jaarsma, D; Korf, J; Sebens, JB | 2 |
| Laurie, DJ; Seeburg, PH | 1 |
| Balcar, VJ; Killinger, S; Li, Y | 1 |
| Hama, AT; Sagen, J; Siegan, JB; Unnerstall, JR | 1 |
| London, ED; Mukhin, A | 1 |
| McEwen, BS; Watanabe, Y; Weiland, NG | 1 |
| Lemaire, S; Shukla, VK | 1 |
| Dumont, M; Lemaire, S | 1 |
| Dumont, M; Lemaire, S; Merali, Z; Shukla, VK | 1 |
| Banks, MD; Fowler, CJ; Sandberg, MP | 1 |
| Bigge, CF; Borosky, SA; Li, JH; Ortwine, DF; Vartanian, MG; Williamson, RM | 1 |
| Nowak, G; Ordway, GA; Paul, IA | 1 |
| Enomoto, R; Ishitsubo, N; Nakahara, F; Ogita, K; Yoneda, Y | 1 |
| Han, D; Ogita, K; Suzuki, T; Yoneda, Y; Zuo, P | 1 |
| Eggeman, KT; Kumar, KN; Michaelis, EK; Pal, R; Walsh, J | 1 |
| Allgeier, H; Angst, C; Baud, J; Gunzenhauser, W; Heckendorn, R | 1 |
| Reynolds, IJ | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P | 1 |
| Brann, DW; Chorich, LP; Mahesh, VB; Zamorano, PL | 1 |
| Oblin, A; Schoemaker, H | 1 |
| Biggio, G; Foddi, MC; Ghiani, CA; Motzo, C; Serra, M | 1 |
| Han, D; Ogita, K; Yoneda, Y | 1 |
| Han, D; Ogita, K; Yoneda, Y; Zuo, P | 1 |
| Layer, RT; Nowak, G; Paul, IA; Skolnick, P; Trullas, R | 1 |
| Dumont, M; Ibrahim, IH; Lapierre, C; Lemaire, S; Parent, P; Rogers, C; Shukla, VK | 1 |
| Bohus, B; Koolhaas, JM; Korf, J; Krugers, HJ | 1 |
| Giberti, A; Mugnaini, M; Ratti, E; van Amsterdam, FT | 1 |
| Atack, JR; Barton, C; Cockett, W; Cook, SM; Gilbert, E; Grimwood, S; Hutson, PH; Le Bourdellès, B; McKernan, RM; Myers, J; Ragan, CI; Whiting, PJ; Wingrove, PB | 1 |
| London, ED; Matsunaga, T; Mukhin, AG | 1 |
| Balcar, VJ; Bennett, MR; Dias, LS; Li, Y | 1 |
| Kendrick, SJ; Lynch, DR; Pritchett, DB | 1 |
| Gribkoff, VK; Molinoff, PB; Zhong, J | 1 |
| Laurie, D; Lowe, DA; Meier, CL; Müller, W; Urwyler, S | 1 |
| Bowery, NG; Mugnaini, M; Ratti, E; Trist, DG; van Amsterdam, FT | 1 |
| Bum, EN; Herrling, PL; Meier, CL; Urwyler, S; Wang, Y | 1 |
| Leonardi, EK; Mytilineou, C; Olanow, CW; Radcliffe, P; Werner, P | 1 |
| Vogel, MW; White, BH | 1 |
| Komiskey, HL; Terse, PS | 1 |
| Adan, J; Capdevila, JL; Martínez, JM; Piulats, J; Tarrason, G; Trullas, R; Zapata, A | 1 |
| Dumont, M; Le, HT; Lemaire, S; Mayer, M; Michelot, R; Nguyen, KP; Ruan, H; Shukla, VK | 1 |
| Cory-Slechta, DA; Garcia-Osuna, M; Greenamyre, JT | 1 |
| Leslie, SW; Randall, PK; Robichon, R | 1 |
| Leibrock, J; Prücher, H; Rautenberg, W | 1 |
| Kovaleva, ES; London, ED; Mukhin, A | 1 |
| Lemaire, S; Prasad, JA; Shukla, VK | 1 |
| Crews, FT; Iimuro, Y; Rudolph, JG; Thurman, RG; Walker, DW | 1 |
| Legutko, B; Nowak, G; Popik, P; Skolnick, P | 1 |
| Becker, A; Hoellt, V; Schroeder, H | 1 |
| Hallak, M | 1 |
| Fowler, CJ; Hedin, H; Jacobsson, SO; Sellström, A | 1 |
| Ahmad, M; Bigge, C; Chen, X; Johnson, PS; Kumar, KN; Michaelis, EK; Pal, R; Ragland, T | 1 |
| Anderson, KJ; Freund, G | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Deakin, JF; Grimwood, S; Hutson, PH; Slater, P | 1 |
| Goshima, Y; Kawashima, K; Misu, Y; Miyamae, T; Ohshima, E; Shibata, T; Shimizu, M; Suzuki, F | 1 |
| Cagnotto, A; Carvelli, L; Comoletti, D; Manzoni, C; Mennini, T; Muzio, V; Rizzi, M; Vezzani, A | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
| Burritt, A; Gandhoke, R; Hruby, VJ; Lai, J; Porreca, F; Tang, Q | 1 |
| Standley, CA | 1 |
| Bains, JS; Curry, K; Pasqualotto, BA; Shaw, CA | 1 |
| Curry, K; Kim, SU; Langmuir, ME; LeCompte, KA; Pasqualotto, BA; Shaw, CA | 1 |
| Itzhak, Y; Martin, JL | 1 |
| Christie, JM; Jane, DE; Monaghan, DT | 1 |
| Healy, DJ; Hogg, AJ; Ibrahim, HM; Meador-Woodruff, JH | 1 |
| Nowak, G; Ossowska, K; Pietraszek, M; Pilc, A; Wardas, J; Wolfarth, S; Zajaczkowski, W | 1 |
| Assmann, S; Foley, EC; Kinney, HC; Panigrahy, A; Rosenberg, PA | 1 |
| Berge, OG; Hökfelt, T; Rydh-Rinder, M | 1 |
| Koller, M; Neijt, H; Urwyler, S | 1 |
| Bowery, NG; Bunnemann, B; Corsi, M; Meoni, P; Mugnaini, M | 1 |
| Meador-Woodruff, JH; Ritter, LM; Unis, AS | 1 |
| Konno, N; Liu, Y; Nakano, K; Tsunoda, M | 1 |
| Brand, L; Harvey, BH; Heenop, M; Jonker, LP; Stein, DJ | 1 |
| Freeman, FM; Rutter, AR; Stephenson, FA | 1 |
| Brück, W; Dirnagl, U; Endres, M; Gertz, K; Gietz, A; Katchanov, J; Veh, RW; Waeber, C; Winter, B | 1 |
| Brehm, L; Clausen, RP; Greenwood, JR; Johansen, TN; Krogsgaard-Larsen, P; Liljefors, T; Nielsen, B; Pickering, DS; Varming, AR; Vogensen, SB | 1 |
| André, N; Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Begtrup, M; Bräuner-Osborne, H; Calí, P; Clausen, RP; Egebjerg, J; Greenwood, JR; Hansen, KB; Nielsen, B | 1 |
| Beneyto, M; Dean, B; Meador-Woodruff, JH; Scarr, E | 1 |
| Beneyto, M; Kristiansen, LV; McCullumsmith, RE; Meador-Woodruff, JH; Oni-Orisan, A | 1 |
| Jäger, AK; Pedersen, ME; Stafford, GI; van Staden, J; Vestergaard, HT | 1 |
| Cilia, J; Cluderay, JE; Emson, PC; Jennings, CA; Jones, DN; Reid, JL; Robbins, MJ; Southam, E; Taylor, A; Turnock-Jones, JJ | 1 |
| Armand, V; Arrang, JM; Bayard, C; Burban, A; Faucard, R; Vorobjev, V | 1 |
| Di Paolo, T; Gasparini, F; Gomez-Mancilla, B; Grégoire, L; Morin, N; Morissette, M | 1 |
2 review(s) available for 2-amino-5-phosphonovalerate and cgp 39653
| Article | Year |
|---|---|
Effect of parenteral magnesium sulfate administration on excitatory amino acid receptors in the rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Blood-Brain Barrier; Hippocampus; Infusions, Parenteral; Magnesium Sulfate; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
The role of glutamate receptors in antipsychotic drug action.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds; Phencyclidine; Rats; Receptors, Metabotropic Glutamate | 2000 |
87 other study(ies) available for 2-amino-5-phosphonovalerate and cgp 39653
| Article | Year |
|---|---|
Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Calcium; Female; Glutathione; Glutathione Disulfide; Kinetics; Male; Neurons; Oxidation-Reduction; Pregnancy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Tritium | 1992 |
Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding Sites; Binding, Competitive; Estradiol; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Ovariectomy; Progesterone; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
N-methyl-D-aspartate receptors are transiently expressed in the developing spinal cord ventral horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamates; Motor Neurons; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
The degeneration of the excitatory climbing fibers enhances [3H]MK-801 and [3H]CGP 39653 binding sites in the rat cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellar Cortex; Dizocilpine Maleate; Kinetics; Male; Nerve Degeneration; Nerve Fibers; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Localization of NMDA and AMPA receptors in rat barrel field.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Cerebral Cortex; Glycine; Ibotenic Acid; Male; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Tritium | 1991 |
Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Cloning, Molecular; Dizocilpine Maleate; DNA; Glutamic Acid; Ion Channels; Kinetics; Kynurenic Acid; Ligands; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 1994 |
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cya
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Kainic Acid; Neurotransmitter Uptake Inhibitors; Prosencephalon; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1995 |
Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Medulla; Animals; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; Nitric Oxide Synthase; Peripheral Nerve Injuries; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Spinal Cord | 1995 |
Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine | 1995 |
Effects of adrenal steroid manipulations and repeated restraint stress on dynorphin mRNA levels and excitatory amino acid receptor binding in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenal Glands; Adrenalectomy; Aldosterone; Androstanols; Animals; Corticosterone; Dynorphins; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; RNA, Messenger; Steroids; Stress, Physiological | 1995 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Binding, Competitive; Brain; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Mice; N-Methylaspartate; Naltrexone; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Glutamate dehydrogenase improves binding of [3H]CGP39653 to NMDA receptors in the autoradiographic assay.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Dynorphin potentiation of [3H]CGP-39653 binding to rat brain membranes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Brain; Dynorphins; In Vitro Techniques; Kinetics; Ligands; Membranes; Narcotics; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
N-methyl-D-aspartate receptor antagonist activity and phencyclidine-like behavioral effects of the pentadecapeptide, [Ser1]histogranin.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Phencyclidine; Proteins; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1995 |
Pharmacological characterization of the N-methyl-D-aspartate (NMDA) receptor recognition site in porcine cerebral cortical membranes using [3H]-CGP 39653.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cell Membrane; Cerebral Cortex; Glycine; Hydrogen-Ion Concentration; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate; Swine; Tritium | 1995 |
Potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonists are substrates for a neutral amino acid uptake system in Chinese hamster ovary cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport Systems; Amino Acids; Animals; Binding, Competitive; Biphenyl Compounds; Carrier Proteins; CHO Cells; Cricetinae; Glutamic Acid; Glycine; Kinetics; Magnetic Resonance Spectroscopy; Membranes; Models, Molecular; Molecular Conformation; Phenylalanine; Propionates; Rats; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Synaptosomes; Tritium | 1995 |
Alterations in the N-methyl-D-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims.
Topics: 2-Amino-5-phosphonovalerate; Adult; Dizocilpine Maleate; Female; Frontal Lobe; Humans; In Vitro Techniques; Kynurenic Acid; Male; Middle Aged; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Suicide | 1995 |
A possible role of glutathione as an endogenous agonist at the N-methyl-D-aspartate recognition domain in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Glutamate Dehydrogenase; Glutamates; Glutathione; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Further evidence for multiple forms of an N-methyl-D-aspartate recognition domain in rat brain using membrane binding techniques.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Brain; Dithionitrobenzoic Acid; Dizocilpine Maleate; Ethylmaleimide; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Reagents; Synaptic Membranes | 1993 |
Immunochemical and immunohistochemical characterization of a synaptic membrane protein that binds the competitive antagonists of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Chromatography, Affinity; Dendrites; Enzyme-Linked Immunosorbent Assay; Immunochemistry; Immunohistochemistry; In Vitro Techniques; Membrane Proteins; Piperazines; Precipitin Tests; Protein Binding; Rats; Receptors, Antigen; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1993 |
Synthesis and binding properties of 2-amino-5-phosphono-3-pentenoic acid photoaffinity ligands as probes for the glutamate recognition site of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Affinity Labels; Animals; Azides; Binding Sites; Brain; Glutamates; Glutamic Acid; Iodine Radioisotopes; Isotope Labeling; Magnetic Resonance Spectroscopy; Molecular Structure; Organophosphorus Compounds; Photochemistry; Rats; Receptors, N-Methyl-D-Aspartate; Spectrometry, Mass, Fast Atom Bombardment | 1993 |
[3H]CGP 39653 binding to the agonist site of the N-methyl-D-aspartate receptor is modulated by Mg2+ and polyamines independently of the arcaine-sensitive polyamine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biguanides; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Glycine; Kinetics; Magnesium; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Tritium | 1994 |
Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Electroshock; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Blotting, Northern; Cerebral Cortex; DNA Probes; Drug Implants; Estradiol; Female; Hypothalamus; Male; Orchiectomy; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Steroids; Testosterone | 1993 |
Complex allosteric modulation of the binding of the NMDA receptor antagonist [3H]CGP39653.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Biguanides; Binding Sites; Glycine; In Vitro Techniques; Kynurenic Acid; Male; Piperidines; Prosencephalon; Putrescine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 1994 |
NMDA receptor function is enhanced in the hippocampus of aged rats.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Male; Organ Specificity; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Tritium | 1994 |
Preferential induction by stress of the N-methyl-D-aspartate recognition domain in discrete structures of rat brain.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Cortex Hormones; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Cerebellum; Corpus Striatum; Cycloheximide; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glycine; Hypothalamus; Kynurenic Acid; Male; N-Methylaspartate; Rats; Rats, Wistar; Stress, Physiological; Tritium | 1994 |
Comparative studies on binding of 3 different ligands to the N-methyl-D-aspartate recognition domain in brain synaptic membranes treated with Triton X-100.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain Chemistry; Detergents; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Octoxynol; Piperazines; Polyethylene Glycols; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1993 |
Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Brain; Dizocilpine Maleate; Drug Administration Schedule; Glycine; Imipramine; In Vitro Techniques; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1993 |
Isolation and characterization of histogranin, a natural peptide with NMDA receptor antagonist activity.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Medulla; Amino Acid Sequence; Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Molecular Sequence Data; Pentazocine; Proteins; Radioimmunoassay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Tissue Distribution | 1993 |
A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Social Behavior; Stress, Psychological | 1993 |
Allosteric modulation of [3H]CGP 39653 binding by glycine in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Animals; Binding Sites; Blotting, Northern; Cell Line; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gene Expression; Glutamine; Glycine; Humans; Mice; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Tritium | 1996 |
Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Nerve Tissue Proteins; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Inhibition of [3H]CGP 39653 binding to NMDA receptors by a P2 antagonist, suramin.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anthelmintics; Autoradiography; Brain; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Frozen Sections; Hippocampus; Male; Purinergic P2 Receptor Antagonists; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Suramin; Tritium | 1995 |
Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cell Line; DNA, Complementary; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Transfection | 1996 |
Use of subunit-specific antisense oligodeoxynucleotides to define developmental changes in the properties of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Base Sequence; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation, Developmental; Glycine; Kynurenic Acid; Macromolecular Substances; Molecular Sequence Data; N-Methylaspartate; Oligonucleotides, Antisense; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Xenopus laevis | 1996 |
Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonist--I. Pharmacological characterization in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Regionally different N-methyl-D-aspartate receptors distinguished by ligand binding and quantitative autoradiography of [3H]-CGP 39653 in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Excitatory Amino Acid Antagonists; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 1996 |
Extracts from rhizomes of Cyperus articulatus (Cyperaceae) displace [3H]CGP39653 and [3H]glycine binding from cortical membranes and selectively inhibit NMDA receptor-mediated neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Male; Membranes; Piperazines; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tritium | 1996 |
L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Culture Media; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Mesencephalon; Monoamine Oxidase Inhibitors; N-Methylaspartate; Neurons; Neuroprotective Agents; Pargyline; Rats; Receptors, Glutamate; Selegiline | 1997 |
CGP 39653 binding in the chick CNS after NMDA receptor antagonist treatment.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Brain Chemistry; Central Nervous System; Cerebellum; Chick Embryo; Excitatory Amino Acid Antagonists; Movement; Prosencephalon; Purkinje Cells; Receptors, N-Methyl-D-Aspartate | 1996 |
Modulation of a competitive N-methyl-D-aspartate receptor antagonist binding by zinc oxide.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Zinc Oxide | 1997 |
Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mice; Oligonucleotides, Antisense; Pipecolic Acids; Radioligand Assay; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Design of potent dynorphin A-(1-9) analogues devoid of supraspinal motor effects in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Drug Synergism; Dynorphins; Excitatory Amino Acid Antagonists; Guinea Pigs; In Vitro Techniques; Male; Mice; Motor Activity; Muscle, Smooth; Peptide Fragments; Rats; Receptors, Opioid, kappa; Structure-Activity Relationship; Tritium | 1997 |
Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Appetitive Behavior; Autoradiography; Brain; Brain Mapping; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Lead Poisoning; Male; Mental Recall; N-Methylaspartate; Organometallic Compounds; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
A partial agonist model used in the allosteric modulation of the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Male; Models, Biological; Protein Binding; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cations; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Protein Binding; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Nonopioid motor effects of dynorphin A and related peptides: structure dependence and role of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Male; Mice; Molecular Sequence Data; Motor Activity; Narcotics; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1997 |
NMDA receptor binding in adult rat brain after several chronic ethanol treatment protocols.
Topics: 2-Amino-5-phosphonovalerate; Alcoholism; Animals; Binding, Competitive; Brain; Brain Mapping; Dizocilpine Maleate; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Adaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors.
Topics: 2-Amino-5-phosphonovalerate; Adaptation, Physiological; Animals; Binding, Competitive; Cerebral Cortex; Citalopram; Excitatory Amino Acid Antagonists; Fluoxetine; Glycine; Male; Mice; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors | 1998 |
Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Chemistry; Convulsants; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Inositol Phosphates; Kindling, Neurologic; Male; Neuroprotective Agents; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
Characterization of the N-methyl-D-aspartate (NMDA) receptor in the embryonic chick brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Blotting, Western; Brain; Brain Chemistry; Calcium; Cell Count; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Immunohistochemistry; Kainic Acid; Neurons; Receptors, N-Methyl-D-Aspartate; Telencephalon | 1998 |
Cloning of a brain N-methyl-D-aspartate- and D, L-epsilon-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653)-binding protein.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Male; Molecular Sequence Data; N-Methylaspartate; Nerve Tissue Proteins; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Glutamate receptors in the cingulate cortex, hippocampus, and cerebellar vermis of alcoholics.
Topics: 2-Amino-5-phosphonovalerate; Aged; Alcoholism; Cerebellar Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Middle Aged; Receptors, Glutamate | 1999 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Binding Sites; Cadaver; Excitatory Amino Acid Antagonists; Humans; Isomerism; Piperidines; Receptors, N-Methyl-D-Aspartate; Reference Values; Schizophrenia; Temporal Lobe; Up-Regulation | 1999 |
Some interactions of L-DOPA and its related compounds with glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kainic Acid; Levodopa; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Xenopus laevis | 1999 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Antibodies; Autoradiography; Blotting, Western; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Mutant Strains; Motor Neurons; Nerve Degeneration; Neurotoxins; Quinoxalines; Receptors, AMPA; Spinal Cord; Tritium | 1999 |
Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone; Tritium | 1999 |
High-affinity interaction of (des-Tyrosyl)dynorphin A(2-17) with NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Dizocilpine Maleate; Dynorphins; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Kidney; Male; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Time Factors | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Convulsants; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; N-Methylaspartate; Pregnancy; Pregnancy, Animal; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Methionine sulfoximine shows excitotoxic actions in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cerebral Cortex; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
A novel fluorescent GSH-adduct binds to the NMDA receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Fetus; Fluorescent Dyes; Humans; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Peptide | 1999 |
Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Brain; Cocaine; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Frontal Lobe; Hippocampus; Kindling, Neurologic; Male; Mice; Motor Activity; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors; Tritium | 2000 |
Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Macaca nemestrina; Neurons; Organ Specificity; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Thalamic Nuclei; Transcription, Genetic; Tritium | 2000 |
Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Stem; Child, Preschool; Excitatory Amino Acid Antagonists; Female; Glycine; Humans; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Middle Aged; Neuroprotective Agents; Phencyclidine; Pregnancy; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Sudden Infant Death | 2000 |
Antinociceptive effects after intrathecal administration of phosphodiester-, 2'-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Genetic Therapy; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Nociceptors; Oligodeoxyribonucleotides, Antisense; Pain Management; Pain Measurement; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 2001 |
Inorganic iron complexes derived from the nitric oxide donor nitroprusside: competitive N-methyl-D-aspartate receptor antagonists with nanomolar affinity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Excitatory Amino Acid Antagonists; Ferrocyanides; In Vitro Techniques; Iron Compounds; Nitric Oxide Donors; Nitroprusside; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2001 |
Allosteric modulation of [3H]-CGP39653 binding through the glycine site of the NMDA receptor: further studies in rat and human brain.
Topics: 2-Amino-5-phosphonovalerate; Aged; Animals; Autoradiography; Brain Chemistry; Excitatory Amino Acid Antagonists; Female; Glycine; Humans; In Vitro Techniques; Indoles; Male; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synaptic Membranes | 2001 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation, Developmental; Humans; Indoles; Kainic Acid; Piperidines; Radioligand Assay; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tritium | 2001 |
Effect of tributyltin on the N-methyl-D-aspartate (NMDA) receptors in the mouse brain.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Body Weight; Cell Membrane; Cerebral Cortex; Dizocilpine Maleate; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Protein Binding; Receptors, N-Methyl-D-Aspartate; Trialkyltin Compounds | 2001 |
NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Imipramine; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Substance Withdrawal Syndrome; Swimming | 2002 |
Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating.
Topics: 2-Amino-5-phosphonovalerate; Binding, Competitive; Cell Line; Dizocilpine Maleate; DNA, Recombinant; Excitatory Amino Acid Antagonists; Genetic Variation; Glutamic Acid; Glycine; Humans; Ion Channel Gating; Nerve Tissue Proteins; Prosencephalon; Receptors, N-Methyl-D-Aspartate | 2002 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sites; Brain Ischemia; Calbindin 2; Cell Count; Cell Survival; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Flumazenil; Functional Laterality; Immunohistochemistry; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Isoquinolines; Mice; Neurons; Parvalbumins; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G; Somatostatin; Staining and Labeling; Time Factors; Tritium | 2003 |
A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chromatography, High Pressure Liquid; Circular Dichroism; Crystallography, X-Ray; Cyclization; Isoxazoles; Models, Molecular; Molecular Conformation; Radioligand Assay; Rats; Receptors, AMPA; Receptors, Kainic Acid; Stereoisomerism | 2004 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nefopam; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sodium Channels; Synaptic Transmission; Tritium | 2004 |
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Topics: 2-Amino-5-phosphonovalerate; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ligands; Membrane Potentials; Models, Molecular; N-Methylaspartate; Pyrazoles; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thermodynamics; Tritium | 2004 |
Cortical glutamatergic markers in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Biomarkers; Case-Control Studies; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; In Situ Hybridization; Kainic Acid; Male; Middle Aged; Postmortem Changes; Radioligand Assay; Receptors, Glutamate; Schizophrenia; Tritium | 2005 |
Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.
Topics: 2-Amino-5-phosphonovalerate; Adult; Analysis of Variance; Autoradiography; Excitatory Amino Acid Antagonists; Female; Gene Expression Regulation; Humans; In Situ Hybridization; Indoles; Male; Middle Aged; Mood Disorders; Postmortem Changes; Protein Binding; Receptors, Glutamate; Schizophrenia; Temporal Lobe | 2007 |
The effect of extracts of Searsia species on epileptiform activity in slices of the mouse cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding, Competitive; Cerebral Cortex; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Indicators and Reagents; Male; Medicine, African Traditional; Mice; Plant Extracts; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Rhus; South Africa | 2008 |
Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Animals, Newborn; Gene Expression Profiling; Gene Expression Regulation; Indoles; Male; Oligonucleotide Array Sequence Analysis; Prefrontal Cortex; Protein Binding; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Social Isolation; Tritium | 2009 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Site; Animals; Binding Sites; Calcium; Dizocilpine Maleate; Drug Synergism; Hippocampus; Histamine; In Vitro Techniques; Intracellular Space; Male; Methylhistamines; N-Methylaspartate; Neurons; Norepinephrine; Piperidines; Polyamines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermine; Synaptosomes | 2010 |
Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Imidazoles; Levodopa; Macaca fascicularis; Oximes; Parkinsonian Disorders; Phenols; Piperidines; Pyridines; Quinazolines; Radioligand Assay; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tritium; Xanthenes | 2013 |