2-amino-5-phosphonovalerate has been researched along with cgp 37849 in 156 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 123 (78.85) | 18.2507 |
| 2000's | 22 (14.10) | 29.6817 |
| 2010's | 10 (6.41) | 24.3611 |
| 2020's | 1 (0.64) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Harrison, BL; McDonald, IA; Weintraub, HJ; Whitten, JP | 1 |
| Nellgård, B; Wieloch, T | 3 |
| Kretschmer, BD; Schmidt, WJ; Volz, L; Volz, TL; Zadow, B | 1 |
| Sage, GP; Sethy, VH | 1 |
| Fink, K; Göthert, M | 2 |
| Bradford, HF; Cotterell, KL; Croucher, MJ | 4 |
| Bischoff, C; Tiedtke, PI | 1 |
| Allegrini, PR; Amacker, H; Fagg, GE; Massieu, L; Sauer, D; Thedinga, KH | 1 |
| Arnold, G; Klockgether, T; Kupsch, A; Oertel, W; Renner, P; Scheid, C; Scheid, R; Wüllner, U | 1 |
| Bagetta, G; Dolly, JO; Nisticó, G | 1 |
| Allegrini, PR; Amacker, H; Bernasconi, R; Fagg, GE; Martin, P; Sauer, D | 1 |
| Arnold, G; Burg, M; Kupsch, A; Löschmann, PA; Oertel, WH; Pufal, D; Renner, P; Sauer, H; ten Bruggencate, G; Wachtel, H | 1 |
| Dziki, M; Hönack, D; Löscher, W | 1 |
| Allegrini, PR; Sauer, D | 1 |
| Bagetta, G; Nisticò, G | 1 |
| Bagetta, G; Bowery, NG; Britton, P; Nisticó, G; Whitton, P | 1 |
| Borkowski, J; Ducret, T; Gentsch, C; Haeusler, A; Hengerer, B; Lederer, R; Mondadori, C; Racine, A | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Hönack, D; Löscher, W | 3 |
| Kannari, K; Markstein, R | 1 |
| Fredow, G; Löscher, W; Richter, A | 1 |
| Baud, J; Baumann, P; Bittiger, H; Fagg, GE; Olpe, HR; Portet, C; Pozza, MF; Schmutz, M; Steinmann, M; Thedinga, K | 1 |
| Brugger, F; Fagg, GE; Olpe, HR; Pozza, MF | 1 |
| Allgeier, H; Fagg, GE; Heckendorn, R; Jeker, A; Klebs, K; Olpe, HR; Portet, C; Schmutz, M; van Riezen, H; Vassout, A | 1 |
| Allgeier, H; Angst, C; Bittiger, H; Brundish, D; Fagg, GE; Heckendorn, R; Olpe, HR; Pozza, MF; Schmutz, M; van Riezen, H | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Hauber, W; Münkle, M | 2 |
| Schmidt, WJ; Tzschentke, TM | 3 |
| Deacon, RM; Rawlins, JN | 1 |
| Servatius, RJ; Shors, TJ | 1 |
| Giffard, RG; Kunis, DM; Maier, CM; Steinberg, GK; Sun, GH | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Little, HJ; Rabbani, M; Wright, EJ | 1 |
| Hartikainen, T; Koivisto, E; Pitkänen, M; Riekkinen, PJ; Sirviö, J; Sivenius, J; Ylinen, A | 1 |
| Allegrini, PR; Da Silva, F; Lüönd, G; Sauer, D; Weber, E | 1 |
| Cameron, HA; Gould, E; McEwen, BS | 2 |
| Moryl, E; Papp, M | 1 |
| Barnes, JC; Gutnikov, SA; Rawlins, JN | 1 |
| Starr, BS; Starr, MS | 3 |
| Gołembiowska, K; Wedzony, K; Zazula, M | 1 |
| Archer, T; Fredriksson, A; Gentsch, C | 1 |
| Allegrini, PR; Fagg, GE; Sauer, D | 1 |
| Bijak, M; Misgeld, U; Rohrbacher, J | 1 |
| D'Hooge, R; De Deyn, PP; Pei, YQ | 1 |
| Hargreaves, RJ; Hill, RG; Iversen, LL; Rigby, M; Smith, D | 1 |
| Annies, R; Hönack, D; Löscher, W | 1 |
| Lederer, R; Mondadori, C; Radeke, E | 1 |
| Czechowska, G; Czuczwar, SJ; Dziki, M; Kleinrok, Z; Pietrasiewicz, T; Turski, WA | 2 |
| Carter, C; Fage, D; Nicolas, C | 1 |
| Bowery, NG; Carletti, R; Gaviraghi, G; Ratti, E | 1 |
| Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q | 1 |
| Daniels, AH; Fujikawa, DG; Kim, JS | 1 |
| Hauber, W; Waldenmeier, MT | 1 |
| Balster, RL; Gold, LH | 1 |
| Brandsgaard, RR; Clissold, DB; Ferkany, JW; Hamilton, GS; Hartman, TL; Willetts, J | 1 |
| Allegrini, PR; Amacker, H; Cosenti, A; Fagg, GE; Pataki, A; Sauer, D | 1 |
| al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE | 1 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Gaffan, D; Gutnikov, SA | 1 |
| Gutnikov, SA; Rawlins, JN | 1 |
| Kumar, V; Lincoln, GA; Tortonese, DJ | 1 |
| Chojnacka-Wójcik, E; Dereń-Wesołek, A; Przegaliński, E; Tatarczyńska, E | 2 |
| Borkowski, J; Gentsch, C; Mondadori, C | 1 |
| Czyrak, A; Fijał, K; Maćkowiak, M; Wedzony, K | 1 |
| Brooks, AN; Howe, DC | 1 |
| Bidzinski, A; Jessa, M; Nazar, M; Plaznik, A | 1 |
| Beckstead, RM | 1 |
| Moryl, E; Papp, M; Zajaczkowski, W | 1 |
| Allegrini, PR; Eis, M; Laurent, D; Sauer, D; Theilkaes, W | 1 |
| Czyrak, A; Wedzony, K | 1 |
| Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Starownik, R | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Patel, S | 1 |
| Biggs, CS; Fowler, LJ; Starr, MS; Whitton, PS | 1 |
| Bienkowski, P; Kostowski, W; Stefanski, R | 1 |
| Maccecchini, ML; Moryl, E; Papp, M | 1 |
| Fujimura, Y; Inukai, T; Kometani, M; Nakao, K; Okada, M; Ueda, H | 1 |
| Black, IB; Elkabes, S; Selcher, JC; Shors, TJ | 1 |
| Brugger, F; Chambers, JP; Evans, RH; Faber, ES | 1 |
| D'Hooge, R; De Deyn, PP; Geelhand, M; Raes, A; Van Bogaert, PP | 1 |
| Fujikawa, DG | 1 |
| Folbergrová, J | 1 |
| Kohjimoto, Y; Kometani, M; Nakao, K; Okada, M; Takahashi, I; Tanaka, I; Ueda, H | 1 |
| Kometani, M; Nakao, K; Okada, M; Ueda, H | 1 |
| Jessa, M; Nazar, M; Płaźnik, A | 1 |
| Bienkowski, P; Koros, E; Kostowski, W; Piasecki, J | 1 |
| Edwards, MA; Kantak, KM; O'Connor, TP | 1 |
| Bianchi, M; Panerai, AE | 1 |
| Cronin, AS; Ebling, FJ | 1 |
| Czuczwar, SJ; Kleinrok, Z; Pilip, S; Turski, WA; Urbanska, EM | 1 |
| Bienkowski, P; Kostowski, W | 1 |
| Günel, MA; Kara, I; Koyuncuoğlu, H; Nurten, A; Yamantürk, P | 1 |
| Wlaź, P | 1 |
| Haugvicová, R; Mares, P | 1 |
| Balster, RL; Compton, AD; Holcomb, JD; McCallum, SE; Porter, JH; Varvel, SA; Wiley, JL | 1 |
| D'Hooge, R; De Deyn, PP; Hiramatsu, M; Mori, A; Raes, A; Van Bogaert, PP | 1 |
| D'Hooge, R; De Deyn, PP; Raes, A; Van Bogaert, PP; Van de Vijver, G | 1 |
| Ebert, U; Löscher, W; Wlaź, P | 1 |
| D'Hooge, R; De Deyn, PP; Hauben, U; Soetens, E | 1 |
| Archer, T; Chase, T; Fredriksson, A; Palomo, T | 1 |
| Kretschmer, BD | 1 |
| Cebers, G; Kovács, AD; Liljequist, S | 1 |
| Shors, TJ | 1 |
| Guidetti, P; Schwarcz, R | 1 |
| Leung, LS; Shen, B | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Hodgkins, PS; Poeggeler, B; Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Frankiewicz, T; Parsons, CG; Pilc, A | 1 |
| Little, HJ; Smith, JW | 1 |
| Bunney, BS; Shi, WX; Zhang, XX | 1 |
| Dooley, DJ; Fink, K; Göthert, M; Meder, W | 1 |
| Chojnacka-Wójcik, E; Przegaliński, E; Tatarczyńska, E | 1 |
| Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z | 1 |
| Ebling, FJ; Ford, H | 1 |
| Fendt, M; Koch, M; Kretschmer, BD | 1 |
| Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M | 1 |
| Shi, WX; Zhang, XX | 1 |
| Bottazzi, B; Garlanda, C; Hirsch, E; Mantovani, A; Moneta, D; Peri, G; Ravizza, T; Richards, GJ; Vezzani, A | 1 |
| Mares, P; Mikulecká, A | 1 |
| Enz, A; Gemperle, AY; Lüthi, A; Olpe, HR; Pozza, MF | 1 |
| D'Hooge, R; De Deyn, PP; Marescau, B; Van Bogaert, PP; Van de Vijver, G; Vanholder, R | 1 |
| Bagetta, G; Corasaniti, MT; Del Duca, C; Dolly, JO; Morrone, AL; Nappi, G; Palma, E; Piccirilli, S | 1 |
| D'Hooge, R; De Deyn, PP; de Vente, J; Marescau, B; Torremans, A; Van Bogaert, PP; Van Dam, D; Van Ginneken, C; Van Meir, F | 1 |
| Boyce-Rustay, JM; Holmes, A | 1 |
| Mares, P; Slamberová, R | 1 |
| Chocyk, A; Fijał, K; Wedzony, K | 1 |
| Fijał, K; Maćkowiak, M; Wedzony, K | 1 |
| Fidecka, S; Kedzierska, E; Nieoczym, D; Nowak, G; Pilc, A; Poleszak, E; Wlaź, P; Wróbel, A | 1 |
| Chocyk, A; Fijal, K; Mackowiak, M; Wedzony, K; Zajaczkowski, W | 1 |
| Dybała, M; Nowak, G; Pilc, A; Poleszak, E; Siwek, A | 1 |
| Choi, DS; Hinton, DJ; Lee, MR; Nam, HW | 1 |
| Bernard, H; Charpier, S; David, O; Depaulis, A; Deransart, C; Langlois, M; Polack, PO | 1 |
| Choi, DS; Choi, S; Hammack, N; Hinton, DJ; Kim, T; Lee, MR; Nam, HW; Wu, J; Yin, JC; Zhu, Y | 1 |
| Nowak, G; Pilc, A; Poleszak, E; Popik, P; Siwek, A; Szewczyk, B; Wolak, M | 1 |
| Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A | 1 |
| Bystrowska, B; Moniczewski, A; Młyniec, K; Nowak, G; Poleszak, E; Rutkowska, A; Siwek, A; Szewczyk, B; Wolak, M | 1 |
| Kim, J; Li, Y | 1 |
| Heimel, JA; Kamphuis, W; Levelt, CN; Min, R; Saiepour, MH | 1 |
| Bruner, RC; Choi, DS; Goeders, NE; Hinton, DJ; Kim, T; Nahar, L; Nam, HW; Oliveros, A; Reker, AN; Sullivan, JM | 1 |
| Latusz, J; Maćkowiak, M | 1 |
| Folbergrová, J; Haugvicová, R; Kubová, H; Mareš, P | 1 |
1 review(s) available for 2-amino-5-phosphonovalerate and cgp 37849
| Article | Year |
|---|---|
CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Anticonvulsants; Binding, Competitive; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
155 other study(ies) available for 2-amino-5-phosphonovalerate and cgp 37849
| Article | Year |
|---|---|
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Modeling of competitive phosphono amino acid NMDA receptor antagonists.
Topics: Binding, Competitive; Computer Simulation; Electricity; Models, Molecular; Organophosphonates; Receptors, N-Methyl-D-Aspartate | 1992 |
NMDA-receptor blockers but not NBQX, an AMPA-receptor antagonist, inhibit spreading depression in the rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cell Membrane Permeability; Cortical Spreading Depression; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Ion Channels; Male; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1992 |
Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Glucose; Blood Pressure; Body Temperature; Cell Death; Dizocilpine Maleate; Hippocampus; Ischemic Attack, Transient; Male; Neurons; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding Sites; Catalepsy; Cycloserine; Dizocilpine Maleate; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Modulation of release of acetylcholine from the striatum by a proposed excitatory amino acid antagonist U-54494A: comparison with known antagonists, diazepam and phenytoin.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Anticonvulsants; Corpus Striatum; Diazepam; Dizocilpine Maleate; In Vitro Techniques; N-Methylaspartate; Phencyclidine; Phenytoin; Potassium; Pyrrolidines; Rats | 1992 |
Presynaptic site of action underlying the ethanol-induced inhibition of norepinephrine release evoked by stimulation of N-methyl-D-aspartate (NMDA) receptors in rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Calcium; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Male; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tetrodotoxin | 1992 |
Weak anticonvulsant activity of CGP 37849 and CGP 39551 against kindled seizures following systemic administration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intravenous; Kindling, Neurologic; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Competitive and non-competitive NMDA receptor antagonists in spatial learning tasks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Learning; Male; Memory; Motor Activity; Orientation; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Binding, Competitive; Electric Stimulation; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Evaluation of quinolinic acid induced excitotoxic neurodegeneration in rat striatum by quantitative magnetic resonance imaging in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Edema; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Magnetic Resonance Imaging; Male; Naloxone; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
The competitive NMDA antagonist CGP40.116 enhances L-dopa response in MPTP-treated marmosets.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Callithrix; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Motor Activity; N-Methylaspartate | 1992 |
Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Diseases; Dizocilpine Maleate; Elapid Venoms; Electroencephalography; Hippocampus; Injections; Male; Nerve Degeneration; Neurotoxins; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magnetic Resonance Imaging; Male; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine | 1992 |
Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Catecholamines; Corpus Striatum; Dizocilpine Maleate; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Tyrosine 3-Monooxygenase | 1992 |
Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Synergism; Female; Kindling, Neurologic; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinical Enzyme Tests; Constriction; Dizocilpine Maleate; Glutamate Decarboxylase; Ischemic Attack, Transient; Magnetic Resonance Imaging; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Inbred F344 | 1992 |
Glutamate transmission is involved in the mechanisms of neuronal degeneration produced by intrahippocampal tetanus toxin in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Male; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tetanus Toxin | 1992 |
Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Cell Death; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists; Insulin Coma; Male; Necrosis; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1992 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; Epilepsy, Generalized; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetanus Toxin | 1992 |
Pretreatment with aldosterone or corticosterone blocks the memory-enhancing effects of nimodipine, captopril, CGP 37,849, and strychnine in mice.
Topics: 2-Amino-5-phosphonovalerate; Aldosterone; Animals; Avoidance Learning; Captopril; Corticosterone; Darkness; Male; Memory; Mice; Nimodipine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Dizocilpine Maleate; Female; Kindling, Neurologic; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
The novel competitive N-methyl-D-aspartate (NMDA) antagonist CGP 37849 preferentially induces phencyclidine-like behavioral effects in kindled rats: attenuation by manipulation of dopamine, alpha-1 and serotonin1A receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Kindling, Neurologic; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Receptors, Serotonin | 1991 |
Dopamine agonists potentiate antiakinetic effects of competitive NMDA-antagonists in monoamine-depleted mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Methyltyrosine; Animals; Binding, Competitive; Caudate Nucleus; Dopamine Agents; Drug Synergism; Dyskinesia, Drug-Induced; Indoles; Male; Methyltyrosines; Mice; Motor Activity; N-Methylaspartate; Piperazines; Putamen; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reserpine | 1991 |
Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cricetinae; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dystonia; Female; Male; Memantine; Mesocricetus; Receptors, N-Methyl-D-Aspartate | 1991 |
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cerebral Cortex; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1991 |
CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Binding, Competitive; Electrophysiology; Electroshock; Glutamates; Hippocampus; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1990 |
Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Electrophysiology; Hippocampus; Iontophoresis; Male; Oxadiazoles; Piperazines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Substantia Nigra; Valine | 1990 |
The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electroshock; Kindling, Neurologic; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Postural Balance; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Stimulation of adenosine A2a receptors in the rat striatum induces catalepsy that is reversed by antagonists of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Anticonvulsants; Catalepsy; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Globus Pallidus; Male; Neural Pathways; Neuroprotective Agents; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical | 1995 |
N-methyl-D-aspartic acid-receptor antagonists block morphine-induced conditioned place preference in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Discrimination, Psychological; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Memory, Short-Term; Psychomotor Performance; Rats; Receptors, N-Methyl-D-Aspartate | 1995 |
Stress-induced sensitization and facilitated learning require NMDA receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Conditioning, Classical; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repression-Sensitization; Stress, Physiological | 1995 |
Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Glucose; Hypoxia; Ischemic Attack, Transient; Mice; Mice, Inbred Strains; Neuroprotective Agents; Rabbits; Receptors, N-Methyl-D-Aspartate | 1995 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; Hypnotics and Sedatives; Male; Mice; Motor Activity; N-Methylaspartate; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1995 |
The effects of NMDA receptor antagonists at anticonvulsive doses on the performance of rats in the water maze task.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Electroshock; Learning; Male; Memory; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Swimming | 1995 |
The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Constriction; Glial Fibrillary Acidic Protein; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; N-Methylaspartate; Rats; Rats, Inbred F344 | 1995 |
Regulation of adult neurogenesis by excitatory input and NMDA receptor activation in the dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Cell Division; Cell Survival; Dizocilpine Maleate; DNA; Hippocampus; Homeostasis; Male; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S Phase; Thymidine; Time Factors | 1995 |
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Depression; Dizocilpine Maleate; Imipramine; Injections, Intraperitoneal; Male; Models, Biological; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Stress, Physiological | 1994 |
Working memory tasks in five-choice operant chambers: use of relative and absolute spatial memories.
Topics: 2-Amino-5-phosphonovalerate; Animals; Appetitive Behavior; Attention; Choice Behavior; Conditioning, Operant; Dextroamphetamine; Male; Memory, Short-Term; Orientation; Problem Solving; Rats; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Scopolamine; Serial Learning | 1994 |
Comparison of the effects of NMDA and AMPA antagonists on the locomotor activity induced by selective D1 and D2 dopamine agonists in reserpine-treated mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Phenethylamines; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine | 1994 |
Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex of rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Benzazepines; Binding, Competitive; Dizocilpine Maleate; Dopamine; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Sulpiride | 1994 |
Synergistic interactions between NMDA-antagonists and L-dopa on activity in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1994 |
The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Pipecolic Acids; Piperazines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate | 1994 |
Suppression by memantine and amantadine of synaptic excitation intrastriatally evoked in rat neostriatal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amantadine; Animals; Antiparkinson Agents; In Vitro Techniques; Memantine; Neostriatum; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1994 |
N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Interactions; Female; Glutamates; Glutamic Acid; Guanidines; Kainic Acid; Ketamine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Succinates | 1993 |
Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Cerebral Cortex; Glucose; Male; Neurons; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Comparison of competitive and uncompetitive NMDA receptor antagonists with regard to monoaminergic neuronal activity and behavioural effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Biogenic Monoamines; Brain; Dizocilpine Maleate; Female; Motor Activity; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 1993 |
Facilitation of social learning by treatment with an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animal Communication; Animals; Avoidance Learning; Learning; Male; Neural Pathways; Rats; Rats, Sprague-Dawley; Retention, Psychology; Social Facilitation | 1993 |
The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Grooming; Limbic System; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Activity; Pilocarpine; Receptors, N-Methyl-D-Aspartate; Seizures | 1994 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Competitive NMDA receptor antagonists enhance the antielectroshock activity of various antiepileptics.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbamazepine; Drug Synergism; Electroshock; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
NMDA receptors with different sensitivities to magnesium and ifenprodil control the release of [14C]acetylcholine and [3H]spermidine from rat striatal slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aminoquinolines; Animals; Carbon Radioisotopes; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Tritium | 1994 |
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Dizocilpine Maleate; In Vitro Techniques; Male; Mice; Receptors, N-Methyl-D-Aspartate | 1994 |
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Brain; Dizocilpine Maleate; Female; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Nerve Degeneration; Nerve Regeneration; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Thymidine; Vimentin | 1994 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; Hippocampus; Male; Mice; Motor Activity; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures; Substance Withdrawal Syndrome | 1994 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroencephalography; Lithium; Male; Neurons; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 1994 |
The AMPA receptor antagonist GYKI 52466 reverses the anti-cataleptic effects of the competitive NMDA receptor antagonist CGP 37849.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Catalepsy; Drug Interactions; Haloperidol; Injections, Intraperitoneal; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1994 |
Effects of NMDA receptor antagonists in squirrel monkeys trained to discriminate the competitive NMDA receptor antagonist NPC 12626 from saline.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Discrimination Learning; Dizocilpine Maleate; Male; Piperazines; Receptors, N-Methyl-D-Aspartate; Saimiri | 1993 |
Competitive antagonists of NMDA receptors, CGP 37849 and CGP 39551, enhance the anticonvulsant activity of valproate against electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 1993 |
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Ataxia; Female; Kindling, Neurologic; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid | 1993 |
Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Binding, Competitive; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Brain Edema; Brain Ischemia; Cats; Magnetic Resonance Imaging; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Epilepsy; Female; Lamotrigine; Male; Motor Activity; Phenytoin; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Triazines | 1993 |
Some central effects of CGP 37849 and CGP 39551, the competitive NMDA receptor antagonists: potential antiparkinsonian activity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Methyltyrosine; Animals; Antiparkinson Agents; Antipsychotic Agents; Biogenic Monoamines; Catalepsy; Central Nervous System Agents; Clonidine; Levodopa; Male; Methyltyrosines; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reserpine; Tyrosine 3-Monooxygenase | 1993 |
Amygdaloid kindling by repeated focal N-methyl-D-aspartate administration: comparison with electrical kindling.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Calcium; Excitatory Amino Acid Agonists; Kindling, Neurologic; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Systemic NMDA receptor antagonist CGP-40116 does not impair memory acquisition but protects against NMDA neurotoxicity in rhesus monkeys.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Macaca mulatta; Male; Memory; Neuroprotective Agents; Neurotoxins; Receptors, N-Methyl-D-Aspartate | 1996 |
Systemic NMDA antagonist CGP-37849 produces non-specific impairment in a working memory task: the effect does not resemble those of AP5 and of lesions of the hippocampus or fornix.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; Memory, Short-Term; Motor Activity; N-Methylaspartate; Rats | 1996 |
Effects of excitatory amino acid receptor agonists and antagonists on the secretion of melatonin, luteinizing hormone and prolactin in the ram.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Luteinizing Hormone; Male; Melatonin; N-Methylaspartate; Photoperiod; Prolactin; Quinoxalines; Radioimmunoassay; Sheep | 1993 |
Morphine-induced catalepsy is augmented by NMDA receptor antagonists, but is partially attenuated by an AMPA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Benzodiazepines; Catalepsy; Dizocilpine Maleate; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors | 1996 |
Anticonflict effects of a competitive NMDA receptor antagonist and a partial agonist at strychnine-insensitive glycine receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Conflict, Psychological; Dose-Response Relationship, Drug; Drinking Behavior; Electroshock; Excitatory Amino Acid Antagonists; Glycine Agents; Hippocampus; Injections; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1996 |
Characterisation of N-methyl-D-aspartate (NMDA)-induced kindling.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Anticonvulsants; Electroencephalography; Kindling, Neurologic; Male; Microinjections; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 1996 |
The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not.
Topics: 2-Amino-5-phosphonovalerate; Aldosterone; Aminoglutethimide; Animals; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mineralocorticoid Receptor Antagonists; Spironolactone | 1996 |
The impact of a competitive and a non-competitive NMDA receptor antagonist on dopaminergic neurotransmission in the rat ventral tegmental area and substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Benzazepines; Binding, Competitive; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Down-Regulation; Excitatory Amino Acid Antagonists; Homovanillic Acid; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior; Substantia Nigra; Synaptic Transmission; Ventral Tegmental Area | 1996 |
The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Catalepsy; Dizocilpine Maleate; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine; Theophylline | 1996 |
Adrenocorticotrophin and luteinizing hormone responses to N-methyl-D-aspartate during fetal development in sheep.
Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Animals; Embryonic and Fetal Development; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gestational Age; Luteinizing Hormone; N-Methylaspartate; Pituitary Gland, Anterior; Sheep | 1996 |
The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Behavior, Animal; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Time Factors | 1996 |
N-methyl-D-aspartate acutely increases proenkephalin mRNA in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Dose-Response Relationship, Drug; Enkephalin, Methionine; Enkephalins; Excitatory Amino Acid Antagonists; Histocytochemistry; In Situ Hybridization; Injections, Intraventricular; Male; N-Methylaspartate; Prosencephalon; Protein Precursors; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P | 1995 |
Discriminative stimulus effects of the NMDA receptor antagonists MK-801 and CGP 37849 in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cues; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Generalization, Stimulus; Male; Memantine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin Agents | 1996 |
Reduction of excitotoxicity-induced brain damage by the competitive NMDA antagonist CGP 40116: a longitudinal study using diffusion-weighted imaging.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Chemistry; Edema; Excitatory Amino Acid Antagonists; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neurotoxins; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Temporal Lobe; Time Factors | 1996 |
Competitive and non-competitive NMDA receptor antagonists induce c-Fos expression in the rat anterior, cingulate cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antibodies; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Genes, fos; Gyrus Cinguli; Male; Neurons; Nuclear Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Ca2+ channel blockade and the antielectroshock activity of NMDA receptor antagonists, CGP 40116 and CGP 43487, in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Excitatory Amino Acid Antagonists; Flunarizine; Male; Mice; Nicardipine; Nifedipine; Receptors, N-Methyl-D-Aspartate | 1996 |
Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance; Epilepsy; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; Male; Motor Activity; Rats; Rats, Sprague-Dawley | 1996 |
NMDA receptor antagonists increase the release of dopamine in the substantia nigra of reserpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dizocilpine Maleate; Dopamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Methyltyrosines; Motor Activity; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reserpine; Substantia Nigra; Tyrosine 3-Monooxygenase | 1996 |
Competitive NMDA receptor antagonist, CGP 40116, substitutes for the discriminative stimulus effects of ethanol.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 1996 |
Differential effects of agents acting at various sites of the NMDA receptor complex in a place preference conditioning model.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Conditioning, Operant; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on ischemic brain damage induced by four-vessel occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Avoidance Learning; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Excitatory Amino Acid Antagonists; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred F344 | 1997 |
Stress persistently increases NMDA receptor-mediated binding of [3H]PDBu (a marker for protein kinase C) in the amygdala, and re-exposure to the stressful context reactivates the increase.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Autoradiography; Biomarkers; Brain; Brain Mapping; Cerebral Cortex; Electroshock; Enzyme Activation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Organ Specificity; Pain; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Stress, Psychological; Tritium | 1997 |
Depression of A and C fibre-evoked segmental reflexes by morphine and clonidine in the in vitro spinal cord of the neonatal rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analgesics, Opioid; Animals; Animals, Newborn; Clonidine; Excitatory Amino Acid Antagonists; Morphine; Rats; Rats, Sprague-Dawley; Spinal Cord | 1997 |
Selective block of N-methyl-D-aspartic acid (NMDA)-evoked whole-cell currents in mouse cultured spinal neurones by CGP 40116.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Mice; N-Methylaspartate; Spinal Cord | 1997 |
Antidepressant-like effects of a partial agonist at strychnine-insensitive glycine receptors and a competitive NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Antidepressive Agents; Behavior, Animal; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
Effects of N-methyl-D-aspartate-receptor blockade on high-potassium-induced neuronal death and glutamate release.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cell Death; Excitatory Amino Acid Antagonists; Glutamic Acid; Microdialysis; Neurons; Potassium; Rats; Rats, Wistar | 1997 |
Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistry; Dizocilpine Maleate; Dose-Response Relationship, Drug; Energy Metabolism; Excitatory Amino Acid Antagonists; Glutamates; Homocysteine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Neuroprotective effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the gerbil model of transient global cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Excitatory Amino Acid Antagonists; Gerbillinae; Ischemic Attack, Transient; Male; Motor Activity; Neurons; Neuroprotective Agents; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate | 1997 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on focal cerebral ischemia in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cats; Cerebral Infarction; Excitatory Amino Acid Antagonists; Image Processing, Computer-Assisted; Male; Neuroprotective Agents; Pipecolic Acids; Receptors, N-Methyl-D-Aspartate | 1997 |
The behavioral effects of NMDA antagonists in serotonin depleted rats.
Topics: 2-Amino-5-phosphonovalerate; 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Conflict, Psychological; Dizocilpine Maleate; Drinking Behavior; Excitatory Amino Acid Antagonists; Male; Pain Threshold; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Agents | 1997 |
Interactions of ethanol with nicotine, dizocilpine, CGP 40116, and 1-(m-chlorophenyl)-biguanide in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Biguanides; Central Nervous System Depressants; Dizocilpine Maleate; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
Modulation of the discriminative stimulus and rate-altering effects of cocaine by competitive and noncompetitive N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding, Competitive; Cocaine; Discrimination Learning; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Drug Interactions; Excitatory Amino Acid Antagonists; Magnesium Chloride; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule | 1998 |
Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol.
Topics: 2-Amino-5-phosphonovalerate; Acetaminophen; Analgesics, Non-Narcotic; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex | 1997 |
Manipulations of glutamatergic (N-methyl-D-aspartate receptor) neurotransmission alter the rate of photoperiodically regulated sexual maturation in the male Siberian hamster.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cricetinae; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Gonadotropin-Releasing Hormone; Male; N-Methylaspartate; Phodopus; Photoperiod; Receptors, N-Methyl-D-Aspartate; Sexual Maturation; Synaptic Transmission; Testis | 1998 |
Chlormethiazole anticonvulsive efficacy diminished by N-methyl-D-aspartate but not kainate in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Chlormethiazole; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Discrimination of ethanol in rats: effects of nicotine, diazepam, CGP 40116, and 1-(m-chlorophenyl)-biguanide.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biguanides; Diazepam; Discrimination Learning; Drug Interactions; Ethanol; GABA Modulators; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Serotonin Receptor Agonists | 1998 |
N-methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Diaphragm; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1998 |
Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antimetabolites; Avoidance Learning; Binding, Competitive; Brain Chemistry; Cycloserine; Dizocilpine Maleate; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists; Ligands; Male; Mice; Neurotoxins; Quinolones; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1998 |
Anticonvulsant action of a NMDA receptor antagonist CGP 40116 varies only quantitatively during ontogeny in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Rats; Receptors, N-Methyl-D-Aspartate; Seizures | 1998 |
Effects of modulation of NMDA neurotransmission on response rate and duration in a conflict procedure in rats.
Topics: 2-Amino-5-phosphonovalerate; Acetamides; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Synaptic Transmission | 1998 |
Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Cells, Cultured; Electric Stimulation; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Postural Balance; Receptors, N-Methyl-D-Aspartate; Seizures; Spinal Cord; Vestibule, Labyrinth | 1998 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kindling, Neurologic; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of oral administration of the competitive N-methyl-D-aspartate antagonist, CGP 40116, on passive avoidance, spatial learning, and neuromotor abilities in mice.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Avoidance Learning; Excitatory Amino Acid Antagonists; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Postural Balance; Receptors, N-Methyl-D-Aspartate | 1999 |
Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Animals; Antiparkinson Agents; Differential Threshold; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Sexual Behavior, Animal | 1999 |
Modulation of the mesolimbic dopamine system by glutamate: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Binding, Competitive; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homovanillic Acid; Limbic System; Male; Microdialysis; Motor Activity; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 1999 |
Prolonged enhancement of AP-1 DNA binding by blockade of glutamate uptake in cultured neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biological Transport; Cells, Cultured; Cerebellum; Dicarboxylic Acids; Dimerization; Dizocilpine Maleate; DNA-Binding Proteins; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transcription Factor AP-1 | 1999 |
Acute stress and re-exposure to the stressful context suppress spontaneous unit activity in the basolateral amygdala via NMDA receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Acute Disease; Amygdala; Animals; Excitatory Amino Acid Antagonists; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recurrence; Stress, Physiological | 1999 |
3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Benzenesulfonates; Corpus Striatum; Drug Synergism; Electron Transport Complex IV; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Kynurenine; Male; Motor Activity; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1999 |
Functional heterogeneity of the rat medial prefrontal cortex: effects of discrete subarea-specific lesions on drug-induced conditioned place preference and behavioural sensitization.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Choice Behavior; Cocaine; Conditioning, Operant; Excitatory Amino Acid Antagonists; Functional Laterality; Male; Morphine; Motor Activity; Prefrontal Cortex; Psychomotor Performance; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reward; Stereotyped Behavior; Time Factors | 1999 |
N-methyl-D-aspartate receptor antagonists are less effective in blocking long-term potentiation at apical than basal dendrites in hippocampal CA1 of awake rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Calcium Channel Blockers; Dendrites; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Membrane Potentials; Nifedipine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Wakefulness | 1999 |
Modulation and function of kynurenic acid in the immature rat brain.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Brain; Dextroamphetamine; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glucose; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Microdialysis; Mixed Function Oxygenases; N-Methylaspartate; Neurons; Pyruvates; Rats; Rats, Sprague-Dawley | 1999 |
Differential effects of NMDA-receptor antagonists on long-term potentiation and hypoxic/hypoglycaemic excitotoxicity in hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Hypoxia; Cells, Cultured; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Differential effects of a dihydropyridine calcium channel antagonist on the components of ethanol tolerance.
Topics: 2-Amino-5-phosphonovalerate; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Ataxia; Body Temperature; Calcium Channel Blockers; Central Nervous System Depressants; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Ethanol; Excitatory Amino Acid Antagonists; Hypothermia; Learning; Male; Motor Activity; Motor Skills; Nimodipine; Practice, Psychological; Rats; Rats, Wistar; Time Factors | 2000 |
Enhancement of NMDA-induced current by the putative NR2B selective antagonist ifenprodil.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Membrane Potentials; N-Methylaspartate; Organ Culture Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine | 2000 |
Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amines; Animals; Aspartic Acid; Calcium; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Male; Neostriatum; Neurons; Neurotransmitter Agents; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Synaptosomes; Tritium | 2000 |
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Drinking Behavior; Electroshock; Excitatory Amino Acid Antagonists; Flumazenil; GABA-A Receptor Antagonists; Male; Maze Learning; Rats; Rats, Wistar; Seizures | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Carotid Artery, Common; gamma-Aminobutyric Acid; Ischemic Attack, Transient; Ischemic Preconditioning; Male; Mice; Muscarinic Agonists; Pilocarpine; Seizures | 2000 |
Glutamatergic regulation of gonadotropin releasing hormone mRNA levels during development in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Gonadotropin-Releasing Hormone; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Neurons; Prosencephalon; RNA, Messenger | 2000 |
Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Baclofen; Central Nervous System Stimulants; Dextroamphetamine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exploratory Behavior; GABA Antagonists; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Neostriatum; Picrotoxin; Proactive Inhibition; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Stereotyped Behavior; Substantia Nigra | 2000 |
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Disease Susceptibility; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; Ischemic Preconditioning; Mice; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Seizures; Time Factors | 2000 |
Dendritic glutamate-induced bursting in prefrontal pyramidal cells: role of NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dendrites; Glutamic Acid; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Genetic Predisposition to Disease; Immunohistochemistry; Kainic Acid; Limbic System; Male; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serum Amyloid P-Component | 2001 |
NMDA receptor antagonists impair motor performance in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2002 |
Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Haloperidol; In Vitro Techniques; Isoxazoles; Magnesium; Male; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors | 2003 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Channels; Cells, Cultured; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Guanidines; Membrane Potentials; Mice; Neurons; Nickel; Piperidines; Potassium Channel Blockers; Seizures; Spermine; Spinal Cord; Succinates; Synapses; Tetraethylammonium; Tetrodotoxin; Uremia | 2003 |
Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Elapid Venoms; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Male; Neurons; Peptides; Potassium Channel Blockers; Rats; Rats, Wistar; Seizures | 2004 |
GSA: behavioral, histological, electrophysiological and neurochemical effects.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain Chemistry; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Escape Reaction; Excitatory Amino Acid Antagonists; Exploratory Behavior; Guanidines; Hippocampus; In Vitro Techniques; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Psychomotor Performance; Reaction Time; Spinal Cord; Succinates; Time Factors | 2005 |
Functional roles of NMDA receptor NR2A and NR2B subunits in the acute intoxicating effects of ethanol in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenols; Piperidines; Receptors, N-Methyl-D-Aspartate; Sleep | 2005 |
Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Motor Cortex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2005 |
Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Axons; Excitatory Amino Acid Antagonists; Female; Immunohistochemistry; Motor Activity; Prefrontal Cortex; Pregnancy; Quinpirole; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tyrosine 3-Monooxygenase | 2005 |
Alterations in the dendritic morphology of prefrontal pyramidal neurons in adult rats after blockade of NMDA receptors in the postnatal period.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Cell Count; Dendrites; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Organ Size; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2005 |
NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Cyclosporine; Dizocilpine Maleate; Magnesium; Male; Mice; Motor Activity; Quinolones; Receptors, N-Methyl-D-Aspartate; Swimming | 2007 |
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Male; Maze Learning; Phencyclidine; Pregnancy; Psychomotor Performance; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Social Behavior | 2008 |
Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antidepressive Agents; Depressive Disorder; Excitatory Amino Acid Antagonists; Mice; Motor Activity; N-Methylaspartate; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Swimming | 2008 |
Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Corpus Striatum; Equilibrative Nucleoside Transporter 1; Ethanol; Glutamic Acid; Male; Mice; Mice, Knockout; Receptors, N-Methyl-D-Aspartate | 2010 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Functional Laterality; GABA-A Receptor Agonists; Hippocampus; Intralaminar Thalamic Nuclei; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Muscimol; N-Methylaspartate; Neurons; Statistics, Nonparametric; Time Factors; Wakefulness | 2010 |
Type 1 equilibrative nucleoside transporter regulates ethanol drinking through accumbal N-methyl-D-aspartate receptor signaling.
Topics: 2-Amino-5-phosphonovalerate; Alcohol Drinking; Analysis of Variance; Animals; Blotting, Western; Cyclic AMP Response Element-Binding Protein; Equilibrative Nucleoside Transporter 1; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Knockout; Microdialysis; Nucleus Accumbens; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Self Administration; Signal Transduction | 2011 |
Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Citalopram; Cyclopropanes; Imipramine; Immobility Response, Tonic; Male; Mice; Milnacipran; Morpholines; Motor Activity; N-Methylaspartate; Oxazines; Quinoxalines; Reboxetine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2013 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ligands; Male; Maze Learning; Mice; N-Methylaspartate; Quinolones; Receptors, N-Methyl-D-Aspartate; Serine | 2013 |
Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Depression; Drug Evaluation, Preclinical; Fluoxetine; Male; Mice; Receptors, N-Methyl-D-Aspartate; Swimming | 2015 |
Deletion of CB2 cannabinoid receptors reduces synaptic transmission and long-term potentiation in the mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Camphanes; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Patch-Clamp Techniques; Pyrazoles; Receptor, Cannabinoid, CB2 | 2016 |
β-Catenin in the Adult Visual Cortex Regulates NMDA-Receptor Function and Visual Responses.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta Catenin; Electric Stimulation; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Parvalbumins; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sensory Deprivation; Synaptic Potentials; Visual Cortex; White Matter | 2018 |
Neurogranin in the nucleus accumbens regulates NMDA receptor tolerance and motivation for ethanol seeking.
Topics: 2-Amino-5-phosphonovalerate; Animals; Central Nervous System Depressants; Conditioning, Operant; Dependovirus; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Ethanol; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motivation; Neurogranin; Nucleus Accumbens; Receptors, N-Methyl-D-Aspartate; Self Administration; Sucrose; Time Factors | 2018 |
Early-life blockade of NMDA receptors induces epigenetic abnormalities in the adult medial prefrontal cortex: possible involvement in memory impairment in trace fear conditioning.
Topics: 2-Amino-5-phosphonovalerate; Acetylation; Animals; Behavior, Animal; Conditioning, Psychological; Epigenesis, Genetic; Excitatory Amino Acid Antagonists; Fear; Histones; Male; Memory; Prefrontal Cortex; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Stereoisomerism | 2019 |