2-amino-5-phosphonovalerate has been researched along with aspartic acid in 272 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 178 (65.44) | 18.7374 |
| 1990's | 66 (24.26) | 18.2507 |
| 2000's | 21 (7.72) | 29.6817 |
| 2010's | 7 (2.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Rekling, JC | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Calo, G; Tomasini, C; Vedovato, M | 1 |
| Chernevskaya, NI; Krishtal, OA; Obukhov, AG | 1 |
| Kuramoto, K; Nishimura, S; Sorimachi, M | 1 |
| Onodera, K; Takeuchi, A | 1 |
| Bagust, J; Gardner, CR; Hussain, S; Walker, RJ | 1 |
| Oja, SS; Saransaari, P | 1 |
| Morita, Y; Nishimura, S; Sorimachi, M | 1 |
| Billard, JM; Daniel, H; Pumain, R | 1 |
| Ohmori, H; Yamaguchi, K | 1 |
| Finch, DM; Fisher, RS; Jackson, MB | 1 |
| Gündel, J; Matthies, H; Steinhäuser, C | 1 |
| Khodorov, B; Sokolova, S; Uteshev, V; Zilberter, Y | 1 |
| Brehm, L; Jørgensen, FS; Krogsgaard-Larsen, P; Madsen, U; Schaumburg, K | 1 |
| Ohno, Y; Warnick, JE | 1 |
| Grudt, TJ; Jahr, CE | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Adams, PR; Guido, W; Lu, SM; Scharfman, HE; Sherman, SM | 1 |
| Dresse, A; Massotte, L; Seutin, V; Verbanck, P | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Davis, M; Melia, KR; Miserendino, MJ; Sananes, CB | 1 |
| Markram, H; Segal, M | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| Clements, JD; Jahr, CE; Lester, RA; Westbrook, GL | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Shirasaki, T; Tateishi, N | 1 |
| Miyamoto, T; Okada, Y; Sakurai, T | 1 |
| Baimbridge, KG; Kessler, M; Lynch, G; Oliver, MW; Shacklock, JA | 1 |
| Becquet, D; Faudon, M; Hery, F | 1 |
| Raigorodsky, G; Urca, G | 3 |
| Fink, K; Göthert, M; Schlicker, E | 1 |
| Reymann, KG; Schröder, H | 1 |
| Ehrenberger, K; Felix, D | 1 |
| Kimura, F; Nishigori, A; Tsumoto, T | 1 |
| Massey, SC; Miller, RF | 1 |
| Girault, JA; Greengard, P; Halpain, S | 1 |
| Butler, TW; Butterfield, GC; Chenard, BL; Dominy, BW; Lipinski, CA; Marinovic, LC; Mena, EE; Pagnozzi, M; Ronau, RT; Tsang, T | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Halsey, MJ; Meldrum, BS; Millan, MH; Wardley-Smith, B | 2 |
| Gonzales, RA; Woodward, JJ | 1 |
| Biesterfeldt, JP; Compton, RP; Cordi, AA; Hood, WF; Lanthorn, TH; Monahan, JB; Vazquez, MI; Wood, PL | 1 |
| Coenen, AM; Peeters, BW; van Rijn, CM; Vossen, JM | 1 |
| Rogers, BC; Tilson, HA | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Fischbach, GD; O'Brien, RJ | 1 |
| Cherubini, E; King, AE; Nistri, A | 1 |
| Moran, J; Patel, AJ | 1 |
| Buerki, H; Fagg, GE; Mondadori, C; Petschke, F; Weiskrantz, L | 1 |
| Buckley, KS; Collins, GG | 1 |
| Bartkowski, H; Roman, R; Simon, R | 1 |
| Chambers, G; Cottrell, JE; Kass, IS | 1 |
| Haberly, LB; Hoffman, WH | 1 |
| Dudek, S; Joly, M; Lynch, G; Muller, D; Schottler, F; Thibault, O | 1 |
| Clow, DW; Jhamandas, K | 1 |
| Girdlestone, D; Thomson, AM; West, DC | 1 |
| Dingledine, R; Kleckner, NW; Verdoorn, TA | 1 |
| Chandler, SH | 1 |
| Greenberg, JH; Karp, A; Reivich, M; Uematsu, D | 1 |
| Ogita, K; Yoneda, Y | 1 |
| Hablitz, JJ; Sutor, B | 1 |
| Brugger, F; Olpe, HR; Pozza, MF; Steinmann, MW | 1 |
| Pierson, MG; Smith, KL; Swann, JW | 1 |
| Chapman, B; Miller, KD; Stryker, MP | 1 |
| Akoev, GN; Andrianov, IuN; Bromm, B; Sabo, T; Sherman, NO | 1 |
| Choi, DW; Hartley, DM | 1 |
| Dun, NJ; Minota, S; Miyazaki, T; Read, HL; Wang, MY | 1 |
| Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA | 1 |
| Caspary, DM; Faingold, CL; Hoffmann, WE | 1 |
| Bowe, MA; Martin, D; Nadler, JV | 1 |
| Aizenman, E; Rosenberg, PA | 1 |
| Davidoff, RA; Hackman, JC; Zhang, DX | 1 |
| Miyachi, E; Murakami, M | 1 |
| Dildy, JE; Leslie, SW | 1 |
| Rakić, L; Shupliakov, OV; Supljakov, OV; Veskov, R; Vesselkin, NP | 1 |
| Bieger, D; Hashim, MA | 1 |
| Itzhak, Y | 1 |
| Dye, J; Heiligenberg, W; Kawasaki, M; Keller, CH | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 1 |
| Scherer, WJ; Udin, SB | 1 |
| Benedetti, M; Frank, C; Sagratella, S; Scotti de Carolis, A | 1 |
| Cherniack, NS; Mitra, J; Overholt, JL; Prabhakar, NR | 2 |
| Smith, SS | 1 |
| Gallagher, JP; Hasuo, H | 1 |
| Avanzini, G; de Curtis, M; Spreafico, R | 1 |
| Choi, DW; Goldberg, MP; Monyer, H; Tecoma, ES | 1 |
| Cline, HT; Constantine-Paton, M | 1 |
| Ben-Ari, Y; Cherubini, E; King, AE | 1 |
| McCaslin, PP; Morgan, WW | 3 |
| Evans, MC; Meldrum, BS; Swan, JH | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A | 1 |
| Arslan, M; Plant, TM; Pohl, CR | 1 |
| De Prins, E; Marrannes, R; Wauquier, A; Willems, R | 1 |
| Jacquet, YF; Squires, RF | 1 |
| Jacquet, YF | 1 |
| Collins, JF; Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Turski, WA | 1 |
| Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E | 1 |
| Gibson, BL; Reif-Lehrer, L | 1 |
| Cunningham, JR; Neal, MJ | 1 |
| Lukasiewicz, PD; McReynolds, JS | 1 |
| Lodge, D; Martin, D | 2 |
| Hablitz, JJ | 1 |
| Martin, MR | 1 |
| Baudry, M; Cummins, JT; Kessler, M; Lynch, G; Way, S | 1 |
| Carpenter, DO; Ffrench-Mullen, JM; Hori, N | 2 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 1 |
| Canning, HM; Leach, MJ; Marden, CM | 1 |
| Collins, KJ; Wheatley, PL | 1 |
| Collins, JF; Stone, TW | 1 |
| Gregersen, H; McLennan, H; Peet, MJ | 1 |
| Gustafsson, B; Huang, YY; Wigström, H | 1 |
| Frenk, H; Liban, A; Teichberg, VI; Urca, G | 1 |
| Nelson, PG; Pun, RY; Westbrook, GL | 1 |
| Koek, W; Ornstein, P; Woods, JH | 1 |
| Stone, TW | 2 |
| Davies, J; Evans, RH; Herrling, PL; Jones, AW; Olverman, HJ; Pook, P; Watkins, JC | 1 |
| Dragunow, M; Goddard, GV; Morimoto, K | 1 |
| De Belleroche, JS; Gardiner, IM; Hamilton, MH; Herberg, LJ | 1 |
| King, AE; Nistri, A | 1 |
| Costa, E; Nicoletti, F; Wroblewski, JT | 1 |
| Johnson, KM; Jones, SM; Snell, LD | 2 |
| Ballanyi, K; Endres, W; Grafe, P; Serve, G | 1 |
| Gordon, FJ | 1 |
| Fagg, GE; Foster, AC | 1 |
| Anderson, WW; Swartzwelder, HS; Wilson, WA | 1 |
| Bliss, TV; Errington, ML; Lynch, MA | 1 |
| Gustafsson, B; Wigström, H | 1 |
| Ito, K; Izumi, Y; Kato, H; Kudo, Y; Miyakawa, H; Ogura, A | 1 |
| Avoli, M; Olivier, A | 1 |
| Cline, HT; Constantine-Paton, M; Debski, EA | 1 |
| Foster, AC; Wong, EH | 1 |
| Crepel, F; Dupont, JL; Gardette, R | 1 |
| Drejer, J; Honoré, T; Schousboe, A | 1 |
| Lees, GJ | 1 |
| Cherniack, NS; Deal, EC; Haxhiu, MA; Norcia, MP; Strohl, KP; van Lunteren, E | 1 |
| Crunelli, V; Kelly, JS; Leresche, N; Pirchio, M | 1 |
| de Carolis, AS; Frank, C; Sagratella, S | 1 |
| Samanin, R; Vezzani, A; Wu, HQ | 1 |
| Bockaert, J; Kemp, DE; Schmidt, BH; Sebben, M; Sladeczek, F; Weiss, S | 1 |
| Knöpfel, T | 1 |
| Barry, MJ; O'Donovan, MJ | 1 |
| Choi, DW; Koh, JY; Peters, S | 1 |
| Hagiwara, S; Hirano, T | 1 |
| Aram, JA; Lodge, D | 1 |
| Childs, AM; Evans, RH; Watkins, JC | 1 |
| Caudle, RM; Isaac, L | 2 |
| Krishtal, OA; Smirnov, SV | 1 |
| Burton, NR; Smith, DA; Stone, TW | 1 |
| Beart, PM; Headley, PM; Nicolopoulos, LS; West, DC | 1 |
| Choi, DW; Coulter, DA; Prince, DA; Wong, BY | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Bockaert, J; Pin, JP; Van-Vliet, BJ | 1 |
| Connick, JH; Stone, TW | 2 |
| Carter, CJ; L'Heureux, R; Scatton, B | 1 |
| Pastuszko, A; Wilson, DF | 1 |
| Nishizaki, T; Okada, Y | 1 |
| Lopes da Silva, FH; Melchers, BP; Pennartz, CM; Wadman, WJ | 1 |
| Lee, M; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Fletcher, EJ; Lodge, D | 1 |
| Dingledine, R; Verdoorn, TA | 1 |
| King, AE; Thompson, SW; Urban, L; Woolf, CJ | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Mayer, ML; Vyklický, L; Westbrook, GL | 1 |
| Ben-Ari, Y; Cherubini, E; Neuman, R | 1 |
| Beitz, AJ; Larson, AA | 1 |
| Lynch, G; Muller, D | 1 |
| Burton, NR; Smith, DA; Stone, TW; Williams, TL | 2 |
| Coleman, PA; Miller, RF | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Beart, PM; Davies, SN; Jones, MG; Lodge, D; Manallack, DT; Millar, J; Ornstein, PL; Verberne, AJ; Young, N | 1 |
| Linden, DJ; Routtenberg, A; Sheu, FS; Wong, KL | 1 |
| Lauritzen, M; Nicholson, C; Okada, Y; Rice, ME | 1 |
| Balázs, R; Hack, N; Jørgensen, OS | 1 |
| Baudry, M; Jung, MW; Larson, J; Lynch, G; Oliver, M; Seubert, P | 1 |
| Ben-Ari, Y; Corradetti, R; Gaïarsa, JL | 1 |
| Armstrong-James, M; Fox, K | 1 |
| Wieloch, T | 1 |
| Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA | 1 |
| Ho, PM; Tang, AH | 1 |
| Cherubini, E; Herrling, PL; Lanfumey, L; Stanzione, P | 1 |
| Balster, RL; Willetts, J | 1 |
| Chapman, AG; Engelsen, B; Meldrum, BS | 1 |
| Compton, RP; Contreras, PC; Monahan, JB; O'Donohue, TL | 1 |
| Do, KQ; Herrling, PL; Turski, WA | 1 |
| Boast, CA; Pastor, G | 1 |
| Balm, M; Coyle, JT; Markl, A; Zaczek, R | 1 |
| Davies, J; Francis, AA; Jones, AW; Watkins, JC | 1 |
| Evans, RH; Watkins, JC | 1 |
| Collins, JF; Curry, K; Perkins, MN; Stone, TW | 1 |
| Collins, JF; Curry, K; Labruyere, J; Olney, JW | 1 |
| Ikeda, H; Sheardown, MJ | 2 |
| Collins, GG | 1 |
| Close, JM; Loewy, AD; Neil, JJ | 1 |
| Lehmann, J; Scatton, B | 1 |
| Davies, J; Watkins, JC | 1 |
| Eng, P; Hösli, E; Hösli, L; Lehmann, R | 1 |
| Collingridge, GL; Kehl, SJ; McLennan, H | 1 |
| Crunelli, V; Forda, S; Kelly, JS | 1 |
| Collins, JF; Croucher, MJ; Curry, K; Czuczwar, SJ; Joseph, M; Meldrum, BS; Stone, TW | 1 |
| Joëls, M; Urban, IJ | 1 |
| Croucher, MJ; Jones, AW; Meldrum, BS; Watkins, JC | 1 |
| McLennan, H | 1 |
| Mayer, ML; Westbrook, GL | 1 |
| Halsey, MJ; Meldrum, BS; Wardley-Smith, B | 1 |
| Czuczwar, SJ; Meldrum, B | 1 |
| Perkins, MN; Stone, TW | 2 |
| Collins, JF; Perkins, MN; Stone, TW | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Glowinski, J; Jay, TM; Pirot, S; Thierry, AM | 1 |
| Balcar, VJ; Killinger, S; Li, Y | 1 |
| Jaarsma, D; Korf, J; Sebens, JB | 1 |
| Croucher, MJ; Patel, DR; Sturt, NJ | 1 |
| López-Colomé, AM; Ortega, A; Romo-de-Vivar, M | 1 |
| Mori, N | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Facchinetti, F; Sparapani, M; Virgili, M | 1 |
| Boulu, RG; Callebert, J; Ghribi, O; Plotkine, M | 1 |
| Sluka, KA; Westlund, KN | 1 |
| Armstrong, JD; Barb, CR; Campbell, RM; Cox, NM | 1 |
| Aistrup, GL; Babcock, KK; Kumar, KN; Michaelis, EK; Schowen, RL; Szentirmay, M | 1 |
| Attwell, D; Sarantis, M; Takahashi, M | 1 |
| Craenen, G; Grants, I; Jeftinija, S; Lucas, JH | 1 |
| Dorandeu, F; Fosbraey, P; Lallement, G; Pernot-Marino, I; Tattersall, JE; Wetherell, J | 1 |
| Barbour, B; Clark, BA | 1 |
| Amano, M; Asari, T; Fukumori, R; Hagiwara, Y; Kubo, T | 1 |
| Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
| Khodorov, BI; Koshelev, SG; Sobolevsky, AI | 1 |
| Lee, YJ; Tsai, LH; Wu, J | 1 |
| D'Hooge, R; De Deyn, PP; Raes, A; Van Bogaert, PP; Van de Vijver, G | 1 |
| Afanas'ev, I; Kudrin, V; Oja, SS; Rayevsky, KS; Saransaari, P; Varga, V | 1 |
| Benz, A; Isenberg, KE; Krause, JE; Mennerick, S; Shen, W; Shimamoto, K; Tanaka, K; Xu, W; Zorumski, CF | 1 |
| Gähwiler, BH; Gerber, U; Jabaudon, D; Scanziani, M | 1 |
| Dooley, DJ; Fink, K; Göthert, M; Meder, W | 1 |
| Onishchenko, NV; Petrov, VI; Sergeyev, VS | 1 |
| Dunlop, J; Eliasof, S; Foster, AC; McIlvain, HB; Petroski, RE | 1 |
| Isaac, JT; Kidd, FL | 1 |
| Schoppa, NE; Westbrook, GL | 1 |
| Hattori, G; Higashi, H; Shigemori, M; Tanaka, E; Yokomizo, Y | 1 |
| Griffith, LC; Nelson, SB; Pratt, KG; Turrigiano, GG; Watt, AJ | 1 |
| Inoue, M; Kawamura, Y; Kudo, Y; Manita, S; Miyakawa, H; Nakamura, T | 1 |
| Campbell, SL; Hablitz, JJ | 2 |
| Lee, YJ; Tsai, LH; Wu, JY | 1 |
| Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
| Ellen, RP; Kwan, CL; McCulloch, CA; Xin, WK; Xu, J; Yu, XM; Zhao, XH | 1 |
| Cohen-Solal, C; de Jesus Ferreira, MC; Guiramand, J; Martin, A; Récasens, M; Vignes, M | 1 |
| Boeck, CR; Bronzatto, MJ; Jardim, FM; Kroth, EH; Souza, DO; Vendite, D | 1 |
| Kang, J; Kang, N; Nedergaard, M; Xu, J; Xu, Q | 1 |
| Terman, GW; Thomson, LM; Zeng, J | 1 |
| Eguchi, K; Kanda, T; Takahashi, T; Yamashita, T | 1 |
| Blankenship, AG; Copenhagen, DR; Edwards, RH; Feller, MB; Ford, KJ; Johnson, J; Seal, RP | 1 |
| Chen, JP; Hsu, KS; Huang, CC; Yeh, CM | 1 |
| Colbert, CM; Eskin, A; Pita-Almenar, JD; Zou, S | 1 |
| Guilarte, TR; Kang, J; Kang, N; Peng, H; Stanton, PK; Yu, Y | 1 |
| Arendt-Nielsen, L; Cairns, BE; Dong, XD; Gazerani, P; Kumar, U; Laursen, JC; Somvanshi, RK | 1 |
| Hermann, GE; Rogers, RC; Vance, KM | 2 |
| Chatton, JY; Rimmele, TS; Rocher, AB; Wellbourne-Wood, J | 1 |
2 review(s) available for 2-amino-5-phosphonovalerate and aspartic acid
| Article | Year |
|---|---|
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
Roles of excitatory amino acids in expression of secondarily generalized limbic seizures: observations in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dimethyl Sulfoxide; Electric Stimulation; Glutamates; Glutamic Acid; Humans; Kindling, Neurologic; Seizures | 1993 |
1 trial(s) available for 2-amino-5-phosphonovalerate and aspartic acid
| Article | Year |
|---|---|
Aspartate and glutamate modulation of growth hormone secretion in the pig: possible site of action.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Aspartic Acid; Body Weight; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glutamic Acid; Growth Hormone; Growth Hormone-Releasing Hormone; N-Methylaspartate; Ovariectomy; Pituitary Gland, Anterior; Serum Albumin; Swine | 1996 |
269 other study(ies) available for 2-amino-5-phosphonovalerate and aspartic acid
| Article | Year |
|---|---|
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Interaction between thyrotropin-releasing hormone (TRH) and NMDA-receptor-mediated responses in hypoglossal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Brain Stem; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Synapses; Tetrodotoxin; Thyrotropin-Releasing Hormone | 1992 |
A simple method for electrical field stimulation of cultured granule cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Neurons; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Temperature; Tetrodotoxin; Veratridine | 1992 |
NMDA receptor agonists selectively block N-type calcium channels in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Aspartic Acid; Calcium; Calcium Channels; Glutamates; Hippocampus; Kynurenic Acid; Mollusk Venoms; N-Methylaspartate; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1991 |
Receptor types mediating the rise in the cytosolic free calcium concentration by L-aspartate and L-glutamate in immature cerebellar neurons with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kinetics; Magnesium; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Uneven distribution of excitatory amino acid receptors on ventral horn neurones of newborn rat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Dendrites; Dose-Response Relationship, Drug; Glutamates; Kainic Acid; Membrane Potentials; N-Methylaspartate; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord | 1991 |
Receptor sub-types involved in responses of Purkinje cell to exogenous excitatory amino acids and local electrical stimulation in cerebellar slices in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cerebellum; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Purkinje Cells; Quinoxalines; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1991 |
Excitatory amino acids evoke taurine release from cerebral cortex slices from adult and developing mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Female; Glutamates; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neurotoxins; Potassium; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Secretory Rate; Stimulation, Chemical; Taurine | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Purkinje Cells; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Sensitivity of rubrospinal neurons to excitatory amino acids in the rat red nucleus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Cats; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Iontophoresis; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Red Nucleus; Species Specificity | 1991 |
Voltage-gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium Channels; Cell Membrane Permeability; Chick Embryo; Cochlear Nerve; Ganglia; Glutamates; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Kinetics; Membrane Potentials; N-Methylaspartate; Potassium Channels; Sodium Channels | 1990 |
Miniature excitatory synaptic currents in cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Aspartic Acid; Calcium Channel Blockers; Cells, Cultured; Dipeptides; Electrophysiology; Fetus; Hippocampus; Kinetics; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Synapses; Tetrodotoxin | 1990 |
Proteolytic enzymes do not destroy the N-methyl-D-aspartate (NMDA) sensitivity of acutely isolated hippocampal CA1 and CA3 neurons from postnatal rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Cell Separation; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Glycine; Hippocampus; Ion Channels; Magnesium; N-Methylaspartate; Neurons; Peptide Hydrolases; Rats | 1990 |
Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Computer Simulation; Ibotenic Acid; Kainic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; N-Methylaspartate; Pipecolic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship | 1990 |
Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Haloperidol; In Vitro Techniques; Magnesium; Male; Methiothepin; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Spinal Cord | 1990 |
Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Electric Stimulation; Glycine; Hippocampus; Indoles; Ion Channel Gating; N-Methylaspartate; Neural Conduction; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Competitive and noncompetitive N-methyl-D-aspartate antagonists modify hypoxia-induced membrane potential changes and protect rat hippocampal slices from functional failure: a quantitative comparison.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Cell Hypoxia; Cell Survival; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1990 |
N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Axons; Calcium; Cats; Electric Stimulation; Evoked Potentials; Geniculate Bodies; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Thalamus; Visual Pathways | 1990 |
Evidence for the presence of N-methyl-D-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tegmentum Mesencephali | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Aspartic Acid; Conditioning, Psychological; Fear; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex, Startle | 1990 |
Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1990 |
Effects of antagonists on N-methyl-D-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Medulla Oblongata; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Evoked Potentials; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Magnesium; Mice; Nerve Degeneration; Optic Nerve; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Visual Cortex | 1990 |
The glycine site modulates NMDA-mediated changes of intracellular free calcium in cultures of hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cells, Cultured; Embryo, Mammalian; Glycine; Hippocampus; Ketamine; Kinetics; Kynurenic Acid; Macromolecular Substances; N-Methylaspartate; Neurons; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine | 1990 |
In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; Cats; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Neurons; Riluzole; Serotonin; Spinal Cord; Synaptic Transmission; Tetrodotoxin; Thiazoles | 1990 |
Spinal antinociceptive effects of excitatory amino acid antagonists: quisqualate modulates the action of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesics; Animals; Aspartic Acid; Dipeptides; Electric Stimulation; Glutamine; Kynurenic Acid; Male; Mice; Motor Activity; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Vocalization, Animal | 1990 |
Veratridine and other depolarizing agents counteract the inhibitory effect of Mg2+ ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amifampridine; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electric Stimulation; Hydrogen; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Veratridine; Veratrine | 1990 |
N-methyl-D-aspartate stimulates the release of dopamine from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dopamine; Hippocampus; Interneurons; Male; Memory; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Tetrodotoxin | 1990 |
A microiontophoretic study of the role of excitatory amino acids at the afferent synapses of mammalian inner hair cells.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Iontophoresis; Male; Neurons, Afferent; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1990 |
Contribution of quisqualate/kainate and NMDA receptors to excitatory synaptic transmission in the rat's visual cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Electrophysiology; Evoked Potentials; Kainic Acid; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, Neurotransmitter; Visual Cortex | 1990 |
N-methyl-D-aspartate receptors of ganglion cells in rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; In Vitro Techniques; N-Methylaspartate; Rabbits; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Valine | 1990 |
Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices.
Topics: Animals; Aspartic Acid; Calcineurin; Calmodulin-Binding Proteins; Colforsin; Corpus Striatum; Cyclic AMP; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; N-Methylaspartate; Nerve Tissue Proteins; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphothreonine; Protein Kinases; Protein Phosphatase 1; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
A unified approach to systematic isosteric substitution for acidic groups and application to NMDA antagonists related to 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Models, Molecular; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Central Nervous System Diseases; High Pressure Neurological Syndrome; Male; Microinjections; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Thalamic Nuclei | 1990 |
Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Culture Techniques; Ethanol; Glycine; Magnesium; Male; N-Methylaspartate; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin; Valine | 1990 |
Differential modulation of the associated glycine recognition site by competitive N-methyl-D-aspartate receptor antagonists.
Topics: Amino Acids; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glycine; Male; N-Methylaspartate; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Electroencephalography; Epilepsy; Female; Injections, Intraventricular; Male; N-Methylaspartate; Rats; Rats, Mutant Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Stereospecificity of N-MDA-induced functional deficits.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Behavior, Animal; Hippocampus; Learning; Male; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred F344; Stereoisomerism | 1990 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; In Vitro Techniques; Ion Channels; Kainic Acid; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Valine | 1986 |
A study of amino acid-activated currents recorded from frog motoneurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction; Oxadiazoles; Quisqualic Acid; Rana temporaria; Valine | 1987 |
Stimulation of the N-methyl-D-aspartate receptor promotes the biochemical differentiation of cerebellar granule neurons and not astrocytes.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Cell Differentiation; Cells, Cultured; Cerebellum; Glutaminase; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA; Valine | 1989 |
NMDA receptor antagonists can enhance or impair learning performance in animals.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gerbillinae; Male; Memory; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Antagonism of monosynaptic excitations in the mouse olfactory cortex slice by 6,7-dinitroquinoxaline-2,3-dione.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reflex, Monosynaptic; Synapses; Synaptic Transmission; Valine | 1989 |
The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Ischemic Attack, Transient; Kinetics; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; Globus Pallidus; Male; N-Methylaspartate; Nervous System Diseases; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Substantia Nigra; Syndrome | 1989 |
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Evoked Potentials; Hippocampus; Hypoxia; In Vitro Techniques; Male; N-Methylaspartate; Neurotoxins; Pyramidal Tracts; Rats; Rats, Inbred Strains; Valine | 1989 |
Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cerebral Cortex; Chlorides; In Vitro Techniques; Ketamine; Magnesium; Membrane Potentials; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Time Factors; Valine | 1989 |
Long-lasting physiological effects of bath applied N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Glycine; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Spermine; Time Factors; Valine | 1989 |
Characterization of L-glutamate action on the release of endogenous dopamine from the rat caudate-putamen.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Oxadiazoles; Phenazocine; Potassium; Putamen; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
A local circuit neocortical synapse that operates via both NMDA and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Dipeptides; Electric Stimulation; Female; Ibotenic Acid; In Vitro Techniques; N-Methylaspartate; Neural Conduction; Oxazoles; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1989 |
N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Kainic Acid; N-Methylaspartate; Oocytes; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Evidence for excitatory amino acid transmission between mesencephalic nucleus of V afferents and jaw-closer motoneurons in the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Guinea Pigs; Kynurenic Acid; Male; Masseter Muscle; Mesencephalon; Motor Neurons; N-Methylaspartate; Neurotransmitter Agents; Synapses; Synaptic Transmission; Trigeminal Nuclei; Valine | 1989 |
Cytosolic free calcium and NAD/NADH redox state in the cat cortex during in vivo activation of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cats; Cerebral Cortex; Cytosol; Fluorescent Dyes; In Vitro Techniques; Male; N-Methylaspartate; NAD; Oxidation-Reduction; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Solubilization of quisqualate-sensitive [3H]glutamate binding activity from rat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Octoxynol; Oxadiazoles; Polyethylene Glycols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Solubility | 1989 |
EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Excitatory amino acid receptors in rat locus coeruleus. An extracellular in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Glutamates; In Vitro Techniques; Kainic Acid; Locus Coeruleus; Magnesium; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Colliculi; N-Methylaspartate; Picrotoxin; Rats; Seizures; Valine | 1989 |
Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cats; Electric Conductivity; Kainic Acid; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Visual Cortex; Visual Perception | 1989 |
[Analysis of the effect of quisqualate, N-methyl-D- aspartate and several blockers of amino acid receptors on synaptic transmission in the ampullae of Lorenzini].
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Electric Fish; Evoked Potentials; Magnesium; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sensory Receptor Cells; Skates, Fish; Synapses; Synaptic Transmission; Valine | 1989 |
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1989 |
Glycine potentiates NMDA responses in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glycine; Hippocampus; Humans; N-Methylaspartate; Rats; Valine | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Valine | 1989 |
Effects of excitant amino acids on acoustic responses of inferior colliculus neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Inferior Colliculi; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains; Valine | 1989 |
A grease-gap method for studying the excitatory amino acid pharmacology of CA1 hippocampal pyramidal cells.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Female; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Valine | 1989 |
Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Electrophysiology; Glutamates; Glycine; Hippocampus; Histocytochemistry; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
NMDA antagonists and potentiation of NMDA-induced motoneuron depolarizations in the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Evoked Potentials; Ketamine; Kynurenic Acid; Magnesium; Motor Neurons; N-Methylaspartate; Potassium; Rana pipiens; Spinal Cord; Valine | 1989 |
Coexistence of NMDA and non-NMDA receptors on turtle horizontal cells revealed using isolated retina preparations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials, Visual; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Turtles; Valine | 1989 |
Ethanol inhibits NMDA-induced increases in free intracellular Ca2+ in dissociated brain cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Brain; Calcium; Cell Separation; Ethanol; Fluorescent Dyes; In Vitro Techniques; Magnesium; N-Methylaspartate; Rats; Rats, Inbred Strains | 1989 |
Penicillin-induced bursting in motoneurones of the frog spinal cord. Elimination by NMDA antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials; In Vitro Techniques; Membrane Potentials; Motor Neurons; N-Methylaspartate; Penicillins; Rana ridibunda; Spinal Cord | 1989 |
Excitatory amino acid receptor-mediated activation of solitarial deglutitive loci.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Deglutition; Dipeptides; Esophagus; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Pharynx; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1989 |
Different modulation of the binding to two phencyclidine (PCP) receptor subtypes: effects of N-methyl-D-aspartate agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Different classes of glutamate receptors mediate distinct behaviors in a single brainstem nucleus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Avoidance Learning; Brain Stem; Electric Fish; Electric Organ; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Algorithms; Animals; Aspartic Acid; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Least-Squares Analysis; Magnesium; Microelectrodes; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Functional Laterality; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Regression Analysis; Superior Colliculi; Visual Fields; Xenopus | 1989 |
Pharmacology of calcium-induced long-term potentiation in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Atropine; Calcium; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Propranolol; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Carbon Dioxide; Carotid Sinus; Cats; Female; Male; Medulla Oblongata; N-Methylaspartate; Phrenic Nerve; Respiration; Tidal Volume; Vagotomy | 1989 |
Quisqualate and N-methyl-D-aspartate synergistically excite cerebellar Purkinje cells as a long-term effect.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Female; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats | 1989 |
Bicuculline- and phaclofen-sensitive components of N-methyl-D-aspartate-induced hyperpolarizations in rat dorsolateral septal nucleus neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Baclofen; Bicuculline; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Septal Nuclei; Tetrodotoxin | 1989 |
Excitatory amino acids mediate responses elicited in vitro by stimulation of cortical afferents to reticularis thalami neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Thalamus | 1989 |
Traumatic neuronal injury in vitro is attenuated by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Dextrorphan; Mice; Morphinans; N-Methylaspartate; Nerve Tissue; Neuroglia; Neurons; Stress, Mechanical | 1989 |
NMDA receptor antagonists disrupt the retinotectal topographic map.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anura; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Superior Colliculi | 1989 |
N-methyl-D-aspartate induces recurrent synchronized burst activity in immature hippocampal CA3 neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Female; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Tetrodotoxin | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum; Cyclic GMP; Female; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1987 |
Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cell Survival; Cerebrovascular Circulation; Hippocampus; Ischemic Attack, Transient; Male; N-Methylaspartate; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Female; Mice; N-Methylaspartate; Phenobarbital; Seizures; Synaptic Transmission; Valproic Acid | 1987 |
DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat.
Topics: Animals; Aspartic Acid; Luteinizing Hormone; Male; N-Methylaspartate; Orchiectomy; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cortical Spreading Depression; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Ketamine; Male; N-Methylaspartate; Phencyclidine; Phenytoin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Excitatory amino acids: role in morphine excitation in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; Motor Activity; N-Methylaspartate; Oxadiazoles; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morphine; N-Methylaspartate; Oxadiazoles; Pain; Periaqueductal Gray; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Muscle relaxant action of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Female; Glutamates; Kynurenic Acid; Male; Muscle Relaxants, Central; Muscle Spasticity; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1985 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cerebellum; Cerebral Cortex; Convulsants; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamine; Hippocampus; Indoles; Male; Mice; Mice, Inbred DBA; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Seizures | 1985 |
Mg2+ reduces N-methyl-D-aspartate neurotoxicity in embryonic chick neural retina in vitro.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Animals; Aspartic Acid; Chick Embryo; In Vitro Techniques; Magnesium; N-Methylaspartate; Retina; Valine | 1985 |
Effect of excitatory amino acids and analogues on [3H]acetylcholine release from amacrine cells of the rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Cholinergic Fibers; Electroretinography; N-Methylaspartate; Neurons; Pipecolic Acids; Rabbits; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Valine | 1985 |
Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; In Vitro Techniques; N-Methylaspartate; Necturus; Receptors, Amino Acid; Receptors, Cell Surface; Retina; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Valine | 1985 |
Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Kainic Acid; Ketamine; Magnesium; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana pipiens; Rana temporaria; Spinal Cord; Valine | 1985 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Evidence for an excitatory amino acid as the transmitter of the auditory nerve in the in vitro mouse cochlear nucleus.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cochlear Nerve; Dose-Response Relationship, Drug; Evoked Potentials; Female; Kainic Acid; Male; Mice; Mice, Inbred C3H; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Receptors, Neurotransmitter; Valine; Vestibulocochlear Nerve | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
A comparison of the effects of quinolinate and N-methyl-aspartate on neurons in rat piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Iontophoresis; N-Methylaspartate; Neurons; Pyridines; Quinolinic Acids; Rats; Valine | 1986 |
Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium; Convulsants; Electric Conductivity; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Valine | 1986 |
(+/-)-cis-2,3-Piperidine dicarboxylic acid is a partial N-methyl-D-aspartate agonist in the in vitro rat cerebellar cGMP model.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Valine | 1986 |
Quantitative studies of N-methyl-D-aspartate, 2-amino-5-phosphonovalerate and cis-2,3-piperidine dicarboxylate interactions on the neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electrophysiology; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Pipecolic Acids; Rats; Rats, Inbred Strains; Spinal Cord; Valine | 1986 |
Activity of beta-kainic acid on neocortical neurons in vivo and hippocampal neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Evoked Potentials, Somatosensory; Hippocampus; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Neurons; Rats; Receptors, Neurotransmitter; Valine | 1986 |
2-Amino-5-phosphonovalerate and Co2+ selectively block depolarization and burst firing of rat hippocampal CA1 pyramidal neurones by N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cobalt; Evoked Potentials; Hippocampus; Iontophoresis; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Tetrodotoxin; Valine | 1986 |
Mode of action of excitatory amino acid receptor antagonists on hippocampal long-lasting potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Guinea Pigs; Hippocampus; In Vitro Techniques; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors; Valine | 1986 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methylaspartate; Picrotoxin; Quinoxalines; Rats; Rats, Inbred Strains; Seizures; Strychnine; Valine | 1986 |
Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Mice; Neurons; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Synapses; Time Factors; Valine | 1986 |
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Injections, Intraventricular; N-Methylaspartate; Phencyclidine; Stereotyped Behavior; Valine | 1986 |
The relative potencies of (-)-2-amino-5-phosphonovalerate and (-)-2-amino-7-phosphonoheptanoate as antagonists of N-methylaspartate and quinolinic acids and repetitive spikes in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1986 |
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Cats; Cell Membrane; Interneurons; Membrane Potentials; Mice; Motor Neurons; N-Methylaspartate; Neurons; Piperazines; Rats; Spinal Cord; Valine | 1986 |
Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Barbiturates; Bicuculline; Brain; Brain Chemistry; Cyclic GMP; Female; Injections, Intraventricular; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains | 1986 |
Deep prepyriform cortex kindling and its relation to amygdala kindling in the rat.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Muscimol; N-Methylaspartate; Rats; Valine | 1986 |
Stimulatory effect of N-methyl aspartate on locomotor activity and transmitter release from rat nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Aspartic Acid; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Motor Activity; N-Methylaspartate; Nialamide; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Valine | 1986 |
Blockade by D-aminophosphonovalerate or Mg2+ of excitatory amino acid-induced responses on spinal motoneurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electric Conductivity; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rana temporaria; Synaptic Transmission; Valine | 1986 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Structure-Activity Relationship; Valine | 1987 |
Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Kainic Acid; Motor Neurons; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Valine | 1986 |
Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Aspartic Acid; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Medulla Oblongata; Microinjections; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Synaptic Transmission; Valine | 1987 |
Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; Epilepsy; Hippocampus; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Valine | 1987 |
Postsynaptic control of hippocampal long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Evoked Potentials; GABA Antagonists; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Picrotoxin; Synapses; Valine | 1986 |
Biphasic effect of quinolinate on frog spinal, but not rat cortical, neurones: N-methyl-D-aspartate-like depolarisation and a novel type of hyperpolarisation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Drug Interactions; Gyrus Cinguli; Kainic Acid; Ketamine; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Valine | 1987 |
Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Benzofurans; Calcium; Cytoplasm; Egtazic Acid; Electric Stimulation; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Pathways; Tetrodotoxin; Valine | 1987 |
Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anticonvulsants; Aspartic Acid; Epilepsy, Temporal Lobe; Humans; In Vitro Techniques; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Temporal Lobe; Valine | 1987 |
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Aspartic Acid; Evoked Potentials, Visual; N-Methylaspartate; Rana pipiens; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Superior Colliculi; Valine | 1987 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apnea; Aspartic Acid; Blood Pressure; Carotid Sinus; Cats; Female; Glutamates; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Oxadiazoles; Phrenic Nerve; Quisqualic Acid; Respiration; Vagotomy; Valine; Vasomotor System | 1987 |
Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellar Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Valine | 1987 |
Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Valine | 1987 |
Effects of ketamine on the in vivo toxicity of quinolinate and N-methyl-D-aspartate in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia, General; Animals; Aspartic Acid; Drug Interactions; Female; Halothane; Hippocampus; Ketamine; N-Methylaspartate; Pentobarbital; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1987 |
Inhibition of N-methyl-D-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Hippocampus; In Vitro Techniques; Magnesium Sulfate; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Potassium; Rats; Rats, Inbred Strains; Valine | 1987 |
A role for the ventral surface of the medulla in regulation of nasal resistance.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Airway Resistance; Animals; Aspartic Acid; Blood Pressure; Cats; Lidocaine; Medulla Oblongata; N-Methylaspartate; Nose; Phrenic Nerve; Receptors, Amino Acid; Receptors, Neurotransmitter; Valine | 1987 |
Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cyclazocine; Epilepsy; Hippocampus; Ketamine; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Synaptic Transmission; Valine | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
Dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Carbachol; Cells, Cultured; Corpus Striatum; Glutamates; Inositol Phosphates; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Sugar Phosphates; Valine | 1987 |
Intrathecal N-methyl-D-aspartate (NMDA) activates both nociceptive and antinociceptive systems.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Aspartic Acid; Behavior, Animal; Decerebrate State; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain; Rats; Valine | 1987 |
Evidence for N-methyl-D-aspartic acid receptor-mediated modulation of the commissural input to central vestibular neurons of the frog.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Anticonvulsants; Aspartic Acid; Brain Stem; Evoked Potentials; Functional Laterality; In Vitro Techniques; Magnesium; Membrane Potentials; Models, Neurological; Neurons; Rana temporaria; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Vestibular Nuclei | 1987 |
The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Chick Embryo; Convulsants; Dipeptides; In Vitro Techniques; Kynurenic Acid; Motor Activity; Motor Neurons; N-Methylaspartate; Spinal Cord; Valine | 1987 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Synaptic transmission between rat cerebellar granule and Purkinje cells in dissociated cell culture: effects of excitatory-amino acid transmitter antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aspartic Acid; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Purkinje Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Tetrodotoxin; Valine | 1988 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro Techniques; Ketamine; Magnesium Deficiency; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
The pharmacological selectivity of three NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hexamethonium Compounds; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Norepinephrine; Piperazines; Rats; Serotonin; Synaptic Transmission; Valine | 1988 |
A novel interaction between dynorphin(1-13) and an N-methyl-D-aspartate site.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Aspartic Acid; Atropine; Binding, Competitive; Dipeptides; Dynorphins; Hot Temperature; Kinetics; Male; N-Methylaspartate; Pain; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Changes in the state of the excitatory synaptic system in the hippocampus on prolonged exposure to excitatory amino acids and antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Animals; Aspartic Acid; Dipeptides; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Valine | 1988 |
A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Male; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1988 |
An excitatory amino acid projection from ventromedial hypothalamus to periaqueductal gray in the rat: autoradiographic and electrophysiological evidence.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Autoradiography; Electric Stimulation; Kainic Acid; Male; N-Methylaspartate; Neural Pathways; Periaqueductal Gray; Rats; Rats, Inbred Strains; Reaction Time; Valine; Ventromedial Hypothalamic Nucleus | 1988 |
Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antitussive Agents; Aspartic Acid; Cerebral Cortex; Dextromethorphan; Dextrorphan; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Levorphanol; Morphinans; N-Methylaspartate; Seizures; Valine | 1988 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
NMDA- and kainate-evoked GABA release from striatal neurones differentiated in primary culture: differential blocking by phencyclidine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1988 |
Differential control by N-methyl-D-aspartate and kainate of striatal dopamine release in vivo: a trans-striatal dialysis study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Atropine; Carbachol; Corpus Striatum; Dopamine; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Amino acids modulate calcium permeability of the plasma membrane of human neuroblastoma cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Calcium; Cell Membrane Permeability; Cysteine; Humans; Kainic Acid; N-Methylaspartate; Neuroblastoma; Neurotransmitter Agents; Tumor Cells, Cultured; Valine | 1988 |
Effects of excitatory amino acids on the oxygen consumption of hippocampal slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Glutamates; Guinea Pigs; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Oxadiazoles; Oxygen Consumption; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spider Venoms; Valine | 1988 |
Influence of dynorphin (1-13) on spinal reflexes in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dynorphins; Electrophysiology; Injections, Spinal; Male; N-Methylaspartate; Nerve Fibers; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Valine | 1988 |
Quantitative correlation between tetanus-induced decreases in extracellular calcium and LTP.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Calcium; Electric Stimulation; Extracellular Space; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Differential effects of N-methyl-D-aspartic acid and L-homocysteic acid on cerebellar Purkinje neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Homocysteine; Iontophoresis; Ketamine; Male; N-Methylaspartate; Purkinje Cells; Rats; Rats, Inbred Strains; Valine | 1988 |
Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Evoked Potentials; Glycine; In Vitro Techniques; N-Methylaspartate; Pyrrolidinones; Rats; Valine | 1988 |
Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chlorides; Female; Ibotenic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oocytes; Oxadiazoles; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Xenopus | 1988 |
An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrodotoxin; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cations, Divalent; Cells, Cultured; Glycine; Hippocampus; Ketamine; Kynurenic Acid; Magnesium; Mice; Mice, Inbred C57BL; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Zinc | 1988 |
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mice; N-Methylaspartate; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Strychnine; Valine | 1988 |
Long-term potentiation differentially affects two components of synaptic responses in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Evoked Potentials, Somatosensory; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Synapses; Valine | 1988 |
Kynurenic acid and AP5 distinguish between NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Ibotenic Acid; Kynurenic Acid; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Do N-methyl-D-aspartate receptors mediate synaptic responses in the mudpuppy retina?
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Aspartic Acid; Electroretinography; Light; N-Methylaspartate; Necturus maculosus; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Stereoisomerism; Synapses; Valine | 1988 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Amino acid pharmacology in neocortical slices: evidence for bimolecular actions from an extension of the Hill and Gaddum-Schild equations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Mathematics; Mice; N-Methylaspartate; Pyridines; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Neurons; Piperazines; Rats; Reflex; Spine; Valine | 1988 |
NMDA receptor blockade prevents the increase in protein kinase C substrate (protein F1) phosphorylation produced by long-term potentiation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; GAP-43 Protein; Hippocampus; Kinetics; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Reference Values; Valine | 1988 |
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cerebellum; Electric Stimulation; In Vitro Techniques; Kainic Acid; Magnesium; N-Methylaspartate; Neural Inhibition; Oxadiazoles; Quisqualic Acid; Turtles; Valine | 1988 |
N-methyl-D-aspartate promotes the survival of cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antigens, Surface; Aspartic Acid; Cell Adhesion Molecules; Cell Survival; Cells, Cultured; Cerebellum; N-Methylaspartate; Nerve Tissue Proteins; Potassium; Rats; Rats, Inbred Strains; Valine | 1988 |
Stimulation of NMDA receptors induces proteolysis of spectrin in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium Chloride; Evoked Potentials; Hippocampus; Hydrolysis; In Vitro Techniques; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spectrin; Valine | 1988 |
D-aminophosphonovaleric acid-sensitive spontaneous giant EPSPs in immature rat hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Piperazines; Rats; Synapses; Tetrodotoxin; Valine | 1988 |
Evidence for a specific role for cortical NMDA receptors in slow-wave sleep.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Cerebral Cortex; Iontophoresis; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sleep; Valine | 1988 |
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Caudate Nucleus; Electroencephalography; Hypoglycemia; Male; N-Methylaspartate; Necrosis; Neurons; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1985 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalography; Male; N-Methylaspartate; Pilocarpine; Rats; Rats, Inbred Strains; Seizures; Stereotaxic Techniques; Substantia Nigra; Synaptic Transmission | 1986 |
2-Amino-7-phosphonoheptanoic acid, a selective N-methyl-D-aspartate antagonist, blocks swim-induced elevation of cerebellar cyclic guanosine monophosphate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellum; Cyclic GMP; Female; Motor Activity; N-Methylaspartate; Rats; Rats, Inbred Strains; Swimming | 1986 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
Excitatory amino acids in synaptic excitation of rat striatal neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamine; In Vitro Techniques; Kynurenic Acid; Magnesium; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Synapses | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Glucose; Insulin; Male; Rats; Rats, Inbred Strains; Seizures | 1987 |
The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1987 |
Effects of L-cysteine-sulphinate and L-aspartate, mixed excitatory amino acid agonists, on the membrane potential of cat caudate neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cats; Caudate Nucleus; Cysteine; Female; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid | 1987 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diazepam; Electroencephalography; Hippocampus; Injections; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1986 |
N-Methyl-D-aspartate and L-aspartate activate distinct receptors in piriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Limbic System; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1984 |
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anura; Aspartic Acid; Cats; Evoked Potentials; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Synapses | 1981 |
Pharmacological antagonists of excitant amino acid action.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aspartic Acid; Kainic Acid; N-Methylaspartate; Neurotransmitter Agents; Oxadiazoles; Quisqualic Acid; Receptors, Drug; Structure-Activity Relationship | 1981 |
Studies with excitatory amino acid antagonists in rat CNS: 2-amino-5-phosphonovaleric acid, phenytoin, and benzodiazepines.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Brain; Cerebral Cortex; Glutamates; Male; Neurons; Phenytoin; Pyramidal Tracts; Pyrrolidinones; Rats | 1981 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
D-aminophosphonovalerate is 100-fold more powerful than D-alpha-aminoadipate in blocking N-methylaspartate neurotoxicity.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids, Dicarboxylic; Animals; Aspartic Acid; Female; Hypothalamus; Male; Mice; N-Methylaspartate; Neurons; Organophosphorus Compounds; Structure-Activity Relationship; Valine | 1981 |
Aspartate may be an excitatory transmitter mediating visual excitation of "sustained" but not "transient" cells in the cat retina: iontophoretic studies in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cats; Dipeptides; Glutamates; Glutamic Acid; Neurons; Neurotransmitter Agents; Retina; Synaptic Transmission; Valine | 1982 |
Some effects of excitatory amino acid receptor antagonists on synaptic transmission in the rat olfactory cortex slice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Aspartic Acid; Culture Techniques; Dipeptides; Electric Stimulation; Evoked Potentials; N-Methylaspartate; Olfactory Bulb; Olfactory Pathways; Pipecolic Acids; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Valine | 1982 |
Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Brain; Dose-Response Relationship, Drug; Female; Heart Rate; Male; N-Methylaspartate; Neurons; Rats; Receptors, Adrenergic; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Valine | 1982 |
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Afferent Pathways; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 1982 |
Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cats; Dipeptides; Female; Glutamates; Glutamic Acid; Male; Pipecolic Acids; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission; Valine | 1983 |
Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Stem; Cells, Cultured; Embryo, Mammalian; Glutamates; Ibotenic Acid; N-Methylaspartate; Oxazoles; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Valine | 1983 |
The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Amino Acids; Animals; Aspartic Acid; Dipeptides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Valine | 1983 |
Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; N-Methylaspartate; Oxadiazoles; Pipecolic Acids; Quisqualic Acid; Rats; Synapses; Valine | 1983 |
A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Rats, Inbred Strains; Seizures; Valine | 1983 |
Functional transmitters at retinal ganglion cells in the cat.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Bicuculline; Cats; Dihydro-beta-Erythroidine; gamma-Aminobutyric Acid; Glycine; Neural Inhibition; Neurotransmitter Agents; Retina; Retinal Ganglion Cells; Strychnine; Valine | 1983 |
Amino acid neurotransmission between fimbria-fornix fibers and neurons in the lateral septum of the rat: a microiontophoretic study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamates; Hippocampus; Iontophoresis; Male; N-Methylaspartate; Nerve Fibers; Neural Pathways; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Septal Nuclei; Synaptic Transmission; Valine | 1984 |
Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Dose-Response Relationship, Drug; Glutamates; Glutamine; Mice; Mice, Inbred DBA; Seizures; Valine | 1984 |
A comparison of the effects of N-methyl-D-aspartate and quinolinate on central neurones of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Iontophoresis; Microinjections; N-Methylaspartate; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Somatosensory Cortex; Spinal Cord; Stimulation, Chemical; Valine | 1984 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Brain; Fasting; Glutamates; Glutamic Acid; Male; Myoclonus; Rats; Rats, Inbred Strains; Seizures; Synaptic Transmission; Syndrome; Tremor | 1984 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kainic Acid; Male; Mice; N-Methylaspartate; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Seizures | 1982 |
In vivo release of [3H]-purines by quinolinic acid and related compounds.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Kynurenic Acid; Male; N-Methylaspartate; Purines; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Tritium | 1983 |
On the interaction of 2-amino-7-phosphono-heptanoic acid and quinolinic acid in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Iontophoresis; Male; Mice; N-Methylaspartate; Neurons; Pyridines; Quinolinic Acids; Seizures | 1983 |
Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Hippocampus; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Neurons; Rats | 1982 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Anatomical and electrophysiological evidence for an excitatory amino acid pathway from the thalamic mediodorsal nucleus to the prefrontal cortex in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Aspartic Acid; Axonal Transport; Electric Stimulation; Glutamic Acid; Male; Neural Conduction; Neural Pathways; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, AMPA; Thalamic Nuclei | 1994 |
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cya
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Kainic Acid; Neurotransmitter Uptake Inhibitors; Prosencephalon; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1995 |
Glutamate dehydrogenase improves binding of [3H]CGP39653 to NMDA receptors in the autoradiographic assay.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Brain; Brain Chemistry; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Modulation of D-[2,3 3H]aspartate release from rat forebrain slices by non-NMDA receptor agonists and antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; Kynurenic Acid; Male; Prosencephalon; Quinoxalines; Rats; Rats, Wistar; Tritium | 1995 |
Excitatory amino acid-induced phosphoinositide hydrolysis in Müller glia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Chickens; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; N-Methylaspartate; Neuroglia; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Retina; Tritium | 1993 |
Long-lasting effects of chronic neonatal blockade of N-methyl-D-aspartate receptor through the competitive antagonist CGP 39551 in rats.
Topics: 2-Amino-5-phosphonovalerate; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Aging; Animals; Animals, Newborn; Aspartic Acid; Benzamides; Benzazepines; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Motor Activity; Nutrition Disorders; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1994 |
Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Extracellular Space; Glutamic Acid; In Vitro Techniques; Ischemic Attack, Transient; Male; Microdialysis; Neostriatum; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1994 |
An experimental arthritis model in rats: the effects of NMDA and non-NMDA antagonists on aspartate and glutamate release in the dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; Aspartic Acid; Carrageenan; Glutamates; Glutamic Acid; Injections, Intra-Articular; Kaolin; Knee Joint; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Ion channel properties of a protein complex with characteristics of a glutamate/N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding Sites; Brain; Calcium; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channels; Lipid Bilayers; Liposomes; Patch-Clamp Techniques; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1996 |
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1996 |
The role of excitatory amino acids in hypothermic injury to mammalian spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cells, Cultured; Cold Temperature; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Mice; Neurons; Receptors, N-Methyl-D-Aspartate; Reference Values; Spinal Cord; Spinal Cord Injuries | 1996 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Aspartic Acid; Dizocilpine Maleate; Elapid Venoms; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neurotoxins; Neurotransmitter Agents; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Currents evoked in Bergmann glial cells by parallel fibre stimulation in rat cerebellar slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cadmium; Cerebellum; Dicarboxylic Acids; Electric Stimulation; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Male; Nerve Fibers; Neuroglia; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Synapses; Tetrodotoxin | 1997 |
Evidence for the involvement of endogenous aspartate in the mediation of carotid chemoreceptor reflexes in the rostral ventrolateral medulla of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Blood Pressure; Carotid Body; Chemoreceptor Cells; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Medulla Oblongata; Microinjections; Phenylephrine; Potassium; Rats; Rats, Wistar; Reflex; Stereotaxic Techniques | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Interaction of memantine and amantadine with agonist-unbound NMDA-receptor channels in acutely isolated rat hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Amantadine; Animals; Aspartic Acid; Evoked Potentials; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; In Vitro Techniques; Memantine; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1998 |
Effect of excitatory amino acid neurotransmitters on acid secretion in the rat stomach.
Topics: 1-Methyl-3-isobutylxanthine; 2-Amino-5-phosphonovalerate; Animals; Aspartate Aminotransferases; Aspartic Acid; Cyclic AMP; Cyclic GMP; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Histamine; Histamine Release; Immunohistochemistry; In Vitro Techniques; Male; Muscarinic Agonists; Neurons; Oxotremorine; Pentagastrin; Piperazines; Rats; Rats, Sprague-Dawley; Stomach | 1999 |
Effects of competitive NMDA receptor antagonists on excitatory amino acid-evoked currents in mouse spinal cord neurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding, Competitive; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Lamotrigine and carbamazepine affect differently the release of D-[3H]aspartate from mouse cerebral cortex slices: involvement of NO.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Carbamazepine; Cerebral Cortex; Enzyme Inhibitors; In Vitro Techniques; Lamotrigine; Male; Mice; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Triazines; Tritium | 1999 |
Substrate turnover by transporters curtails synaptic glutamate transients.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzothiadiazines; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Membrane Potentials; N-Methylaspartate; Neuroglia; Neurons; Oocytes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xenopus laevis | 1999 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Brain Ischemia; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kinetics; Membrane Potentials; N-Methylaspartate; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Patch-Clamp Techniques; Pyrrolidines; Quinoxalines; Rats | 2000 |
Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amines; Animals; Aspartic Acid; Calcium; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Male; Neostriatum; Neurons; Neurotransmitter Agents; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Synaptosomes; Tritium | 2000 |
The effect of N-acetyl-L-aspartic acid dilithium salt on dopamine release and synthesis in the rat striatum in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Male; N-Methylaspartate; Rats; Rats, Wistar; Time Factors | 2001 |
Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Carrier Proteins; Cell Line; Cerebellum; Cerebral Cortex; Dogs; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Kidney; Kinetics; Neurotransmitter Uptake Inhibitors; Oocytes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Neurotransmitter; Recombinant Fusion Proteins; Symporters; Synaptosomes; Xenopus laevis | 2001 |
Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Kinetics; Organ Culture Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Kainic Acid; Synapses; Synaptic Transmission; Temperature; Thalamus | 2001 |
Glomerulus-specific synchronization of mitral cells in the olfactory bulb.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kinetics; N-Methylaspartate; Olfactory Bulb; Olfactory Receptor Neurons; Periodicity; Quinoxalines; Rats; Rats, Sprague-Dawley; Smell | 2001 |
Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Aspartic Acid; Astrocytes; Calcium Channel Blockers; Cobalt; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium Channel Blockers; Tetraethylammonium; Tetrodotoxin | 2003 |
Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII.
Topics: Alanine; Anesthetics, Local; Animals; Animals, Newborn; Aspartic Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Count; Cell Surface Extensions; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Lysine; Mutation; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Organ Culture Techniques; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Rats, Long-Evans; Synapses; Synapsins; Synaptic Transmission; Tetrodotoxin; Threonine; Transfection; Valine | 2003 |
Glutamate release increases during mossy-CA3 LTP but not during Schaffer-CA1 LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Colforsin; Coloring Agents; Cyclopropanes; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Long-Term Potentiation; Magnesium; Male; Mossy Fibers, Hippocampal; Neuroglia; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Glutamate transporters regulate excitability in local networks in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Neocortex; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Temperature | 2004 |
Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine.
Topics: Acids; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspartic Acid; Cimetidine; Drug Interactions; Gastric Mucosa; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Immunohistochemistry; Laser-Doppler Flowmetry; Male; N-Methylaspartate; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Time Factors; Tripelennamine; Valine; Yohimbine | 2004 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
A functional interaction of sodium and calcium in the regulation of NMDA receptor activity by remote NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Hippocampus; Ion Channel Gating; Ionophores; Monensin; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptor Cross-Talk; Receptors, N-Methyl-D-Aspartate; Sodium; Sodium Channel Blockers; Tetrodotoxin; Thapsigargin | 2005 |
Gliotoxicity in hippocampal cultures is induced by transportable, but not by nontransportable, glutamate uptake inhibitors.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Neuroglia; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 2005 |
Effects of glutamate transporter and receptor ligands on neuronal glutamate uptake.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ligands; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Oxepins; Rats; Rats, Wistar; Receptors, Glutamate; Tritium; Valine | 2005 |
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Diagnostic Imaging; Drug Interactions; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Microscopy, Confocal; Neurons; Neurotoxins; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetanus Toxin; Tetrodotoxin; Time Factors | 2005 |
Differential effect of glutamate transporter inhibition on EPSCs in the morphine naïve and morphine tolerant neonatal spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Analysis of Variance; Animals; Aspartic Acid; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Morphine; Narcotics; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2006 |
Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kainic Acid; Malformations of Cortical Development; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2008 |
Vesicular glutamate filling and AMPA receptor occupancy at the calyx of Held synapse of immature rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Benzothiadiazines; Brain Stem; Excitatory Postsynaptic Potentials; Glutamic Acid; Kynurenic Acid; Patch-Clamp Techniques; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Vesicles; Temperature; Tetrodotoxin | 2009 |
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Topics: Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Aspartic Acid; Calcium; Dihydro-beta-Erythroidine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Time Factors; Valine; Vesicular Glutamate Transport Protein 1 | 2009 |
Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Topics: Adrenalectomy; Androgens; Animals; Animals, Newborn; Aspartic Acid; CA1 Region, Hippocampal; Corticosterone; Dexamethasone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Statistics, Nonparametric; Stress, Psychological; Synaptosomes; Testosterone; Valine | 2012 |
Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Biotinylation; Cells, Cultured; Colforsin; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Indoles; Kainic Acid; Long-Term Potentiation; Male; Neurons; Protein Transport; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Valine | 2012 |
Astrocytes release D-serine by a large vesicle.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Calcium; Cytoplasmic Vesicles; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exocytosis; Female; Glycine; Hippocampus; In Vitro Techniques; Male; Microscopy, Electron, Transmission; Patch-Clamp Techniques; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Serine; Valine | 2013 |
Glutamate dysregulation in the trigeminal ganglion: a novel mechanism for peripheral sensitization of the craniofacial region.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Lidocaine; Male; Mice; Muscle, Skeletal; Neural Conduction; Neurons; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Time Factors; Trigeminal Ganglion | 2014 |
NMDA receptors control vagal afferent excitability in the nucleus of the solitary tract.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Afferent Pathways; Animals; Aspartic Acid; Benzimidazoles; Calcium; Excitatory Amino Acid Antagonists; In Vitro Techniques; Piperidines; Pregnenolone; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Sulfonamides; Vagus Nerve | 2015 |
PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Astrocytes; Calcium; Citrates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Miniature Postsynaptic Potentials; Neurons, Afferent; Peptide Fragments; Rats; Rats, Long-Evans; Receptor, PAR-1; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Synapses; Vagus Nerve | 2015 |
Control of Glutamate Transport by Extracellular Potassium: Basis for a Negative Feedback on Synaptic Transmission.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cerebral Cortex; Excitatory Amino Acid Antagonists; Extracellular Fluid; GABA-A Receptor Antagonists; Glutamic Acid; HEK293 Cells; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Potassium; Synaptic Transmission; Xanthenes | 2017 |