2-amino-5-phosphonovalerate has been researched along with 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (17.53) | 18.7374 |
| 1990's | 64 (65.98) | 18.2507 |
| 2000's | 14 (14.43) | 29.6817 |
| 2010's | 2 (2.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Bigge, CF; Brahce, LJ; Coughenour, LL; Drummond, JT; Johnson, G; Marcoux, FW; Ortwine, DF; Probert, AW; Retz, DM | 1 |
| Baron, BM; McDonald, IA; Miller, F; Muench, D; White, HS; Whitten, JP | 1 |
| Bigge, CF; Bobovski, TP; Brahce, LJ; Coughenour, LL; Drummond, JT; Hays, SJ; Johnson, G; Novak, PM; Rice, MJ | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Hisanaga, K; Sagar, SM; Sharp, FR | 1 |
| Dawes, E; Hankins, M; Ikeda, H | 1 |
| Ishii, T; Masu, M; Moriyoshi, K; Nakanishi, S; Sugihara, H | 1 |
| Borghese, CM; Carrer, HF; Keller, EA; Ramirez, OA | 1 |
| Bilkey, DK; Holmes, KH; Laverty, R | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| Davies, J; Harris, NC | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Russo, RE; Velluti, JC | 1 |
| Beckstead, RM; Somers, DL | 1 |
| Alasuzoff, I; Briggs, RS; Cowburn, RF; Porter, RH; Roberts, PJ | 1 |
| Bieger, D; Neuman, RS; Wang, YT | 1 |
| Avoli, M; Hwa, GG; Oliver, A; Villemure, JG | 1 |
| Kuramoto, K; Nishimura, S; Sorimachi, M | 1 |
| Monaghan, DT | 1 |
| Hatziefthimiou, A; Kouvelas, ED; Mitsacos, A; Mitsaki, E; Plaitakis, A | 1 |
| Esguerra, M; Kwon, YH; Sur, M | 1 |
| Katki, AG; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| Benveniste, M; Mayer, ML | 1 |
| Bazil, MK; Gordon, FJ | 1 |
| Insel, TR; Skolnick, P; Trullas, R; Winslow, JT | 1 |
| Bilkey, DK; Goddard, GV; Holmes, KH; Laverty, R | 1 |
| Moody, CI; Murphy, PC; Salt, TE; Sillito, AM | 1 |
| Aitken, PG; Friedman, A; Somjen, GG; Urban, L | 1 |
| Benveniste, M; Mayer, ML; Mienville, JM; Sernagor, E | 1 |
| Gotoh, Y; Ishida, M; Shinozaki, H | 1 |
| Akaike, N; Murase, K; Nakagawa, T; Shirasaki, T; Tateishi, N | 1 |
| Brugger, F; Fagg, GE; Olpe, HR; Pozza, MF | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Hata, N; Nishikawa, T; Takahashi, K; Umino, A | 1 |
| Chiamulera, C; Costa, S; Reggiani, A | 1 |
| Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI | 1 |
| Meldrum, BS; Swan, JH | 1 |
| Lanthorn, TH; Rader, RK; Watson, GB | 1 |
| Arnolde, SM; Nevins, ME | 1 |
| Burgard, EC; Decker, G; Sarvey, JM | 1 |
| Costa, E; Danysz, W; Fadda, E; Wroblewski, JT | 1 |
| Scherer, WJ; Udin, SB | 1 |
| Ben-Ari, Y; Cherubini, E; Corradetti, R; Gaiarsa, JL | 1 |
| Evans, RH; Krijzer, F; Long, SK | 1 |
| Lehmann, J; Tsai, C; Wood, PL | 1 |
| Davies, J; Evans, RH; Herrling, PL; Jones, AW; Olverman, HJ; Pook, P; Watkins, JC | 1 |
| Childs, AM; Evans, RH; Watkins, JC | 1 |
| Ben-Ari, Y; Cherubini, E; Neuman, R | 1 |
| Beart, PM; Davies, SN; Jones, MG; Lodge, D; Manallack, DT; Millar, J; Ornstein, PL; Verberne, AJ; Young, N | 1 |
| Ben-Ari, Y; Corradetti, R; Gaïarsa, JL | 1 |
| Ho, PM; Tang, AH | 1 |
| Balster, RL; Willetts, J | 1 |
| Bradford, HF; Croucher, MJ; Sunter, DC; Watkins, JC | 1 |
| Boast, CA; Pastor, G | 1 |
| Berger, I; Gillis, RA; Kelly, M; Magee, S; McManigle, JE; Norman, WP; Panico, WH; Taveira DaSilva, AM; Vitagliano, S | 1 |
| Herrling, PL; Krucker, T; Meier, CL; Salt, TE; Seno, N | 1 |
| Ammendola, D; De Sarro, A; De Sarro, G; Nava, F | 1 |
| Kaufman, MP; Motekaitis, AM; Solomon, IC; Wong, MK | 1 |
| Starr, BS; Starr, MS | 2 |
| Avoli, M; Mattia, D; Perreault, P; Siniscalchi, A; Tomaiuolo, F | 1 |
| Han, D; Ogita, K; Suzuki, T; Yoneda, Y; Zuo, P | 1 |
| Eggeman, KT; Kumar, KN; Michaelis, EK; Pal, R; Walsh, J | 1 |
| Hargreaves, RJ; Hill, RG; Iversen, LL; Rigby, M; Smith, D | 1 |
| Bradford, HF; Croucher, MJ; Kaura, S; Sunter, DC; Watkins, JC | 1 |
| Hill, JM; Kaufman, MP; Pickar, JG | 1 |
| Hasegawa, T; Kameyama, T; Kinoshita, H; Nabeshima, T; Yamamoto, I | 1 |
| Han, D; Ogita, K; Yoneda, Y; Zuo, P | 1 |
| Larson, AA; Sun, X | 1 |
| Giberti, A; Mugnaini, M; Ratti, E; van Amsterdam, FT | 1 |
| Bianchi, L; Giovannini, MG; Michelassi, A; Mutolo, D; Pepeu, G | 1 |
| Cordery, PM; Smith, AL; Thompson, ID | 1 |
| Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME | 1 |
| Betz, H; Hirai, H; Kuhse, J; Laube, B; Sturgess, M | 1 |
| Hrabetova, S; Sacktor, TC | 1 |
| Janáky, R; Jenei, Z; Oja, SS; Saransaari, P; Varga, V | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohno, Y; Ohtani, K; Sakamoto, H; Tamamura, C; Tanaka, H; Yasuda, H | 1 |
| Lee, YJ; Tsai, LH; Wu, J | 1 |
| Faber, DS; Kumar, SS | 1 |
| Binns, KE; Salt, TE; Turner, JP | 1 |
| Alavez, S; Hurtado, S; Moran, J; Rivera-Gaxiola, M; Valencia, A | 1 |
| Fadda, F; Mameli, M; Mancinelli, R; Rossetti, ZL; Vargiu, R | 1 |
| Kelly, JB; Kidd, SA | 1 |
| Gemignani, A; Paudice, P; Pittaluga, A; Raiteri, M | 1 |
| Eshak, M; Iannotti, F; Pringle, AK; Self, J | 1 |
| Cornish, JL; Kalivas, PW; Nakamura, M | 1 |
| Alcocer, I; Bermúdez-Rattoni, F; Escobar, ML | 1 |
| Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C | 1 |
| Kelly, JB; Ma, CL; Wu, SH | 1 |
| Farkas, S; Kocsis, P; Szombathelyi, Z; Tarnawa, I | 1 |
| Behnisch, T; Frey, JU; Leutgeb, JK | 1 |
| Baviera, M; Calcagno, E; Carli, M; Ceglia, I; Invernizzi, RW; Renoldi, G | 1 |
| Adams, JP; Dudek, SM; Zhao, M | 1 |
| Kostopoulos, G; Moschovos, C; Papatheodoropoulos, C | 1 |
| Kenney, J; Manahan-Vaughan, D | 1 |
| Davies, DA; Greba, Q; Howland, JG; Hurtubise, JL | 1 |
97 other study(ies) available for 2-amino-5-phosphonovalerate and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid
| Article | Year |
|---|---|
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.
Topics: Amino Acids; Animals; Binding, Competitive; Brain; Cells, Cultured; Models, Molecular; Molecular Conformation; N-Methylaspartate; Organophosphonates; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kindling, Neurologic; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 1990 |
New and versatile approaches to the synthesis of CPP-related competitive NMDA antagonists. Preliminary structure-activity relationships and pharmacological evaluation.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; N-Methylaspartate; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes | 1990 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
N-methyl-D-aspartate antagonists block fos-like protein expression induced via multiple signaling pathways in cultured cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Fetus; Glutamates; Glutamic Acid; Immunohistochemistry; N-Methylaspartate; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Signal Transduction | 1992 |
Spontaneous firing level distinguishes the effects of NMDA and non-NMDA receptor antagonists on the ganglion cells in the cat retina.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cats; Dizocilpine Maleate; Evoked Potentials, Visual; Ganglia; Iontophoresis; Kynurenic Acid; Piperazines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Retina | 1992 |
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Base Sequence; Chromosome Deletion; Cloning, Molecular; Dizocilpine Maleate; DNA; Gene Library; Kynurenic Acid; Molecular Sequence Data; N-Methylaspartate; Oocytes; Piperazines; Prosencephalon; Rats; Receptors, N-Methyl-D-Aspartate; Restriction Mapping; RNA Splicing; RNA, Messenger; Xenopus | 1992 |
The learning capacity of high or low performance rats is related to the hippocampus NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Conditioning, Operant; Hippocampus; Kinetics; Learning; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Reference Values | 1992 |
The infusion of an NMDA antagonist into perirhinal cortex suppresses amygdala-kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cerebral Cortex; Injections; Kindling, Neurologic; Male; Olfactory Bulb; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cats; Electric Stimulation; Neurons; Pipecolic Acids; Piperazines; Receptors, N-Methyl-D-Aspartate; Red Nucleus; Somatosensory Cortex; Synapses; Synaptic Transmission | 1992 |
Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Male; Memory; N-Methylaspartate; Pipecolic Acids; Piperazines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1992 |
Inhibitory effects of excitatory amino acids on pyramidal cells of the in vitro turtle medial cortex.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cerebral Cortex; Electric Stimulation; Electroencephalography; Electrophysiology; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Membrane Potentials; N-Methylaspartate; Piperazines; Pyramidal Tracts; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin; Turtles | 1992 |
N-methyl-D-aspartate receptor antagonism alters substance P and met5-enkephalin biosynthesis in neurons of the rat striatum.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Enkephalins; Male; N-Methylaspartate; Neurons; Piperazines; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Substance P; Tachykinins; Valine | 1992 |
Heterogeneity of NMDA receptors labelled with [3H]3-((+-)-2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H]CPP): receptor status in Alzheimer's disease brains.
Topics: 2-Amino-5-phosphonovalerate; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Animals; Binding Sites; Brain Chemistry; Cerebral Cortex; Humans; In Vitro Techniques; Kinetics; Male; Piperazines; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1992 |
Activation of NMDA receptors is necessary for fast information transfer at brainstem vagal motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Brain Stem; Electric Stimulation; Evoked Potentials, Somatosensory; Histocytochemistry; Male; Medulla Oblongata; Motor Neurons; Neural Pathways; Piperazines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Vagus Nerve | 1991 |
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Potentials; Humans; In Vitro Techniques; Membrane Potentials; Piperazines; Receptors, N-Methyl-D-Aspartate; Synapses | 1991 |
Receptor types mediating the rise in the cytosolic free calcium concentration by L-aspartate and L-glutamate in immature cerebellar neurons with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Dizocilpine Maleate; Glutamates; Glutamic Acid; Kinetics; Magnesium; Neurons; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors.
Topics: Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; In Vitro Techniques; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Thalamus; Valine | 1991 |
Quantitative autoradiographic study of L-glutamate binding sites in normal and atrophic human cerebellum.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebellum; Female; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Male; N-Methylaspartate; Olivopontocerebellar Atrophies; Piperazines; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cats; Electric Stimulation; Evoked Potentials; Geniculate Bodies; Kainic Acid; N-Methylaspartate; Neurons; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Time Factors; Visual Perception | 1991 |
L-homocysteate stimulates [3H]MK-801 binding to the phencyclidine recognition site and is thus an agonist for the N-methyl-D-aspartate-operated cation channel.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Homocysteine; In Vitro Techniques; Ion Channels; Kinetics; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism; Stimulation, Chemical | 1990 |
Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding Sites; Biophysical Phenomena; Biophysics; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ion Channels; Kinetics; Kynurenic Acid; Models, Neurological; Piperazines; Receptors, N-Methyl-D-Aspartate | 1991 |
Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Evoked Potentials; Female; Glutamates; Heart Rate; Medulla Oblongata; Microinjections; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Sympathetic Nervous System | 1991 |
Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Female; Glycine; Hippocampus; Kynurenic Acid; Male; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Social Isolation; Vocalization, Animal | 1990 |
The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Dependence of retinogeniculate transmission in cat on NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Cats; Female; Geniculate Bodies; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Retinal Ganglion Cells; Synaptic Transmission; Visual Pathways | 1990 |
An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Electric Stimulation; Epilepsy; Hippocampus; Humans; In Vitro Techniques; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Aspartic Acid; Cells, Cultured; Glycine; Hippocampus; Kynurenic Acid; Mice; N-Methylaspartate; Neurons; Osmolar Concentration; Piperazines | 1990 |
Selective N-methyl-D-aspartate (NMDA) antagonists increase gastric motility in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autonomic Nervous System; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stomach | 1990 |
Effects of antagonists on N-methyl-D-aspartate response in acutely isolated nucleus tractus solitarii neurons of the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; In Vitro Techniques; Medulla Oblongata; N-Methylaspartate; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Electrophysiology; Hippocampus; Iontophoresis; Male; Oxadiazoles; Piperazines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Substantia Nigra; Valine | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Evidence for involvement of N-methyl-D-aspartate receptor in tonic inhibitory control of dopaminergic transmission in rat medial frontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Cerebral Cortex; Dopamine; Glutamine; Infusions, Parenteral; Isomerism; Male; Methyltyrosines; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic Acid; Learning; Male; Mice; N-Methylaspartate; Piperazines; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1990 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Fever; Phenotype; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures; Synaptic Membranes | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Male; N-Methylaspartate; Neurons; Pipecolic Acids; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; Pentylenetetrazole; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
NMDA receptor antagonists block norepinephrine-induced long-lasting potentiation and long-term potentiation in rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Piperazines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Binding Sites; Binding, Competitive; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Kynurenic Acid; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Subcellular Fractions; Valine | 1989 |
N-methyl-D-aspartate antagonists prevent interaction of binocular maps in Xenopus tectum.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Functional Laterality; N-Methylaspartate; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reference Values; Regression Analysis; Superior Colliculi; Visual Fields; Xenopus | 1989 |
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Animals, Newborn; Bicuculline; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Ketamine; Membrane Potentials; Phencyclidine; Picrotoxin; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Effects of depressant amino acids and antagonists on an in vitro spinal cord preparation from the adult rat.
Topics: Action Potentials; Amino Acids; Animals; Bicuculline; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; Picrotoxin; Piperazines; Rats; Spinal Cord; Strychnine; Synapses; Taurine; Valine | 1989 |
Homocysteic acid as a putative excitatory amino acid neurotransmitter: I. Postsynaptic characteristics at N-methyl-D-aspartate-type receptors on striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Choline; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Homocysteine; Interneurons; Magnesium; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereoisomerism; Tachyphylaxis; Tiletamine | 1988 |
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Binding Sites; Brain; Cats; Cell Membrane; Interneurons; Membrane Potentials; Mice; Motor Neurons; N-Methylaspartate; Neurons; Piperazines; Rats; Spinal Cord; Valine | 1986 |
The pharmacological selectivity of three NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Hexamethonium Compounds; In Vitro Techniques; Motor Neurons; N-Methylaspartate; Norepinephrine; Piperazines; Rats; Serotonin; Synaptic Transmission; Valine | 1988 |
Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Hippocampus; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; N-Methylaspartate; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Binding, Competitive; In Vitro Techniques; N-Methylaspartate; Neurons; Piperazines; Rats; Reflex; Spine; Valine | 1988 |
D-aminophosphonovaleric acid-sensitive spontaneous giant EPSPs in immature rat hippocampal neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Piperazines; Rats; Synapses; Tetrodotoxin; Valine | 1988 |
Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Discrimination, Psychological; Dizocilpine Maleate; Light; Male; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred F344 | 1988 |
The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Discrimination, Psychological; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; Methohexital; N-Methylaspartate; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Inhibition of the development of electrical kindling of the prepyriform cortex by daily focal injections of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Electrophysiology; Glutamine; Injections; Kindling, Neurologic; Male; Piperazines; Rats; Rats, Inbred Strains | 1988 |
Characterization of motor activity patterns induced by N-methyl-D-aspartate antagonists in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Electronic Data Processing; Female; Gerbillinae; Ketamine; Motor Activity; N-Methylaspartate; Pipecolic Acids; Piperazines; Piperidines; Time Factors | 1987 |
NMDA receptors are involved at the ventrolateral nucleus tractus solitarii for termination of inspiration.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Apnea; Blood Pressure; Cats; Female; Heart Rate; Male; Microinjections; N-Methylaspartate; Piperazines; Pulmonary Ventilation; Receptors, N-Methyl-D-Aspartate; Respiration; Solitary Nucleus; Vagotomy | 1995 |
Thalamocortical and corticocortical excitatory postsynaptic potentials mediated by excitatory amino acid receptors in the cat motor cortex in vivo.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Electric Stimulation; Electrophysiology; Evoked Potentials; Female; Male; Motor Cortex; Piperazines; Pyramidal Tracts; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Thalamus | 1995 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acids; Glutamine; Imipenem; Kynurenic Acid; Mice; Mice, Inbred DBA; Muscimol; Piperazines; Piperidines; Quinoxalines; Seizures | 1995 |
NMDA receptors in caudal ventrolateral medulla mediate reflex airway dilation arising from the hindlimb.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Airway Resistance; Animals; Dogs; Electric Stimulation; Hindlimb; Lung; Medulla Oblongata; Microinjections; Muscle Contraction; Muscle, Skeletal; Neurons, Afferent; Piperazines; Receptors, N-Methyl-D-Aspartate; Reflex; Sciatic Nerve | 1994 |
Comparison of the effects of NMDA and AMPA antagonists on the locomotor activity induced by selective D1 and D2 dopamine agonists in reserpine-treated mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agonists; Male; Mice; Mice, Inbred Strains; Motor Activity; Phenethylamines; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Reserpine | 1994 |
Pharmacology and electrophysiology of a synchronous GABA-mediated potential in the human neocortex.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Humans; Male; Piperazines; Tetrodotoxin | 1994 |
Further evidence for multiple forms of an N-methyl-D-aspartate recognition domain in rat brain using membrane binding techniques.
Topics: 2-Amino-5-phosphonovalerate; 4-Chloromercuribenzenesulfonate; Animals; Brain; Dithionitrobenzoic Acid; Dizocilpine Maleate; Ethylmaleimide; Glutamates; Glutamic Acid; Kinetics; Male; N-Methylaspartate; Piperazines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Reagents; Synaptic Membranes | 1993 |
Immunochemical and immunohistochemical characterization of a synaptic membrane protein that binds the competitive antagonists of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Chromatography, Affinity; Dendrites; Enzyme-Linked Immunosorbent Assay; Immunochemistry; Immunohistochemistry; In Vitro Techniques; Membrane Proteins; Piperazines; Precipitin Tests; Protein Binding; Rats; Receptors, Antigen; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1993 |
Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Cerebral Cortex; Glucose; Male; Neurons; Pipecolic Acids; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dizocilpine Maleate; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Pilocarpine; Piperazines; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Seizures | 1993 |
Relative anticonvulsant potencies of CPP and some novel analogues in the kindled rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Kindling, Neurologic; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 1993 |
Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Blood Pressure; Cats; Heart Rate; Hypnotics and Sedatives; Injections, Spinal; Muscle Contraction; Neurokinin-1 Receptor Antagonists; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Time Factors | 1994 |
Competitive NMDA antagonists enhance the catalepsy induced by delta 9-tetrahydrocannabinol in mice.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amantadine; Amino Acids; Animals; Anticonvulsants; Catalepsy; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Ergolines; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperazines; Quinpirole; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1994 |
Comparative studies on binding of 3 different ligands to the N-methyl-D-aspartate recognition domain in brain synaptic membranes treated with Triton X-100.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain Chemistry; Detergents; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Octoxynol; Piperazines; Polyethylene Glycols; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1993 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
Allosteric modulation of [3H]CGP 39653 binding by glycine in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Glycine; Kinetics; Kynurenic Acid; Male; Piperazines; Rats; Rats, Sprague-Dawley; Tritium | 1993 |
NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Amino Acids; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Male; Microdialysis; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Tetrodotoxin | 1994 |
Manufacture and release characteristics of Elvax polymers containing glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Drug Carriers; Drug Implants; Excitatory Amino Acid Antagonists; Ferrets; Molecular Weight; N-Methylaspartate; Piperazines; Polyvinyls; Receptors, Glutamate | 1995 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Maleate; Electroencephalography; Injections, Intraventricular; Male; Motor Cortex; Neuroprotective Agents; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Stereotaxic Techniques | 1996 |
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Binding Sites; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Ion Channel Gating; Models, Molecular; Molecular Sequence Data; Piperazines; Receptors, N-Methyl-D-Aspartate; Sequence Alignment; Sequence Homology, Amino Acid | 1997 |
Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Magnesium; Neuronal Plasticity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1997 |
Role of histidyl residues in the binding of ligands to the porcine N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cerebral Cortex; Diethyl Pyrocarbonate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Histidine; Ionophores; Kainic Acid; Ligands; N-Methylaspartate; Piperazines; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Swine; Synaptic Membranes; Tritium | 1997 |
Selective depression of the spinal polysynaptic reflex by the NMDA receptor antagonists in an isolated spinal cord in vitro.
Topics: Animals; Depression, Chemical; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Kynurenic Acid; Male; Piperazines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Reflex, Monosynaptic; Serine; Spinal Cord; Spinal Nerve Roots; Strychnine; Valine | 1997 |
Effect of excitatory amino acid neurotransmitters on acid secretion in the rat stomach.
Topics: 1-Methyl-3-isobutylxanthine; 2-Amino-5-phosphonovalerate; Animals; Aspartate Aminotransferases; Aspartic Acid; Cyclic AMP; Cyclic GMP; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Histamine; Histamine Release; Immunohistochemistry; In Vitro Techniques; Male; Muscarinic Agonists; Neurons; Oxotremorine; Pentagastrin; Piperazines; Rats; Rats, Sprague-Dawley; Stomach | 1999 |
Plasticity of first-order sensory synapses: interactions between homosynaptic long-term potentiation and heterosynaptically evoked dopaminergic potentiation.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzazepines; Calcium; Chelating Agents; Dopamine; Dopamine Antagonists; Egtazic Acid; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Goldfish; In Vitro Techniques; Long-Term Potentiation; Neurons, Afferent; Patch-Clamp Techniques; Piperazines; Receptors, N-Methyl-D-Aspartate; Spiperone; Synapses; Vestibulocochlear Nerve | 1999 |
Visual experience alters the molecular profile of NMDA-receptor-mediated sensory transmission.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dark Adaptation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; N-Methylaspartate; Neurons, Afferent; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Synaptic Transmission; Visual Pathways | 1999 |
Effect of NMDA antagonists on the activity of glutaminase and aspartate aminotransferase in the developing rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Aspartate Aminotransferases; Body Weight; Cell Differentiation; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutaminase; L-Lactate Dehydrogenase; Male; Nerve Fibers; Nerve Tissue Proteins; Neurons; Organ Specificity; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Biphasic effects of NMDA on the motility of the rat portal vein.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth, Vascular; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Piperazines; Portal Vein; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Vasodilator Agents | 2000 |
NMDA and AMPA receptors in the dorsal nucleus of the lateral lemniscus shape binaural responses in rat inferior colliculus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acoustic Stimulation; Animals; Cochlear Nucleus; Excitatory Amino Acid Antagonists; Functional Laterality; Hearing; In Vitro Techniques; Inferior Colliculi; Male; Piperazines; Pons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors | 2000 |
The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cholecystokinin; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; HIV Envelope Protein gp120; HIV-1; Indoles; Kynurenic Acid; Male; Maleimides; Neurons; Nitroarginine; Peptide Fragments; Pipecolic Acids; Piperazines; Piperidines; Potassium; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Somatostatin; Synaptic Transmission; Synaptosomes; Zinc | 2000 |
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Ischemic Attack, Transient; Memantine; N-Methylaspartate; Neurons; Neuroprotective Agents; Organ Culture Techniques; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Dopamine-independent locomotion following blockade of N-methyl-D-aspartate receptors in the ventral tegmental area.
Topics: 2-Amino-5-phosphonovalerate; Animals; Baclofen; Benzazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Locomotion; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2001 |
In vivo effects of intracortical administration of NMDA and metabotropic glutamate receptors antagonists on neocortical long-term potentiation and conditioned taste aversion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Benzoates; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Male; Microinjections; N-Methylaspartate; Neocortex; Piperazines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Taste | 2002 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Mutant Strains; Morphine; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Pain Measurement; Piperazines; Piperidines; Pyrrolidinones; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Spinal Cord; Subarachnoid Space | 2002 |
AMPA and NMDA receptors mediate synaptic excitation in the rat's inferior colliculus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Inferior Colliculi; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2002 |
Participation of AMPA- and NMDA-type excitatory amino acid receptors in the spinal reflex transmission, in rat.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; In Vitro Techniques; Magnesium; Models, Neurological; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Reflex, Monosynaptic; Spinal Cord; Synapses; Time Factors; Valine | 2003 |
LTP in cultured hippocampal-entorhinal cortex slices from young adult (P25-30) rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Electrophysiology; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Immunoblotting; Immunohistochemistry; Long-Term Potentiation; Nerve Net; Organ Culture Techniques; Picrotoxin; Piperazines; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 2003 |
The 5-HT receptor antagonist M100,907 prevents extracellular glutamate rising in response to NMDA receptor blockade in the mPFC.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Extracellular Space; Fluorobenzenes; Glutamic Acid; Male; Microdialysis; Nicotine; Piperazines; Piperidines; Potassium Chloride; Prefrontal Cortex; Rats; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Tetrodotoxin | 2004 |
Pattern-dependent role of NMDA receptors in action potential generation: consequences on extracellular signal-regulated kinase activation.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Long-Term Potentiation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
Greater contribution of N-methyl-D-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Space; Hippocampus; In Vitro Techniques; Magnesium; Male; Piperazines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2005 |
NMDA receptor-dependent synaptic plasticity in dorsal and intermediate hippocampus exhibits distinct frequency-dependent profiles.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate | 2013 |
Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: role of NMDA receptors.
Topics: Animals; Cephalosporins; Choice Behavior; Ciprofloxacin; Conditioning, Operant; Corpus Striatum; Dose-Response Relationship, Drug; Male; Piperazines; Prefrontal Cortex; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Space Perception; Touch; Valine | 2017 |