2-amino-4-phosphonobutyric acid has been researched along with glutamic acid in 118 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (27.97) | 18.7374 |
| 1990's | 45 (38.14) | 18.2507 |
| 2000's | 33 (27.97) | 29.6817 |
| 2010's | 6 (5.08) | 24.3611 |
| 2020's | 1 (0.85) | 2.80 |
| Authors | Studies |
|---|---|
| Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Clodfelter, DK; Collado, I; Kulanthaivel, P; Pedregal, C; Schoepp, DD; Stoddard, EA; Wheeler, WJ; Wright, RA | 1 |
| Lieberman, EM; Sanzenbacher, E | 1 |
| Copenhagen, DR; Takahashi, K | 1 |
| Rainnie, DG; Shinnick-Gallagher, P | 1 |
| Ames, A; Li, YY | 1 |
| Haldeman, B; Kristensen, P; Mulvihill, E; Suzdak, PD; Thomsen, C | 1 |
| Evans, PD; Merzon, RM; Reale, V; Villegas, J | 1 |
| Hirano, AA; MacLeish, PR | 1 |
| Garcia-Ladona, FJ; Girard, C; Gombos, G; Palacios, JM | 1 |
| Jahr, CE; Nawy, S | 1 |
| Wässle, H; Yamashita, M | 1 |
| Jones, PG; Roberts, PJ | 1 |
| Adamson, P; Brammer, MJ; Campbell, IC; Hajimohammadreza, I; Meldrum, BS | 1 |
| Boos, R; Müller, F; Wässle, H | 1 |
| Berry, BW; Boland, LM; Dingledine, R; Hoch, DB | 1 |
| Baty, LT; Gannon, RL; Terrian, DM | 1 |
| Wu, SM; Yang, XL | 1 |
| Bloomfield, SA; Dowling, JE | 1 |
| Kimura, H; Okamoto, K; Sakai, Y | 1 |
| Brussmann, A; Buselmaier, W; Sahai, S | 1 |
| Bartel, R; Bigner, DD; Campbell, GL; Freidman, HS | 1 |
| Butcher, SP; Collins, JF; Roberts, PJ | 2 |
| Hablitz, JJ | 1 |
| Carlin, R; Siekevitz, P; Wu, K | 1 |
| Baudry, M; Cummins, JT; Kessler, M; Lynch, G; Way, S | 1 |
| Costa, E; Iadarola, MJ; Nicoletti, F; Wroblewski, JT | 1 |
| Aleksandrov, VG; Lapin, IP; Mandel'shtam, IuE; Ryzhov, IV; Slepokurov, MV | 1 |
| Gullak, MF; Mena, EE; Pagnozzi, MJ | 1 |
| Quinn, MR; Spraguer, PA | 1 |
| Davies, SW; Roberts, PJ | 1 |
| Arqueros, L; Bustos, G; Fiedler, JL | 1 |
| Compton, RP; Hood, WF; Michel, J; Monahan, JB; Olney, JW; Price, MT; Pullan, LM | 1 |
| Crunelli, V; Kelly, JS; Leresche, N; Pirchio, M | 1 |
| Cotman, CW; Harris, EW; Stevens, DR | 1 |
| Alho, H; Costa, E; Eva, C; Fadda, E; Nicoletti, F; Wroblewski, JT | 1 |
| Walker, JB; Woznicki, DT | 1 |
| Cowburn, RF; Hardy, JA; Roberts, PJ | 1 |
| Mitchell, CK; Redburn, DA | 2 |
| Auker, CR; Braitman, DJ; Carpenter, DO; Hori, N | 1 |
| Cotman, CW; Fagg, GE; Foster, AC; Harris, EW; Lanthorn, TH | 1 |
| Cotman, CW; Fagg, GE; Foster, AC; Mena, EE | 1 |
| Sawada, S; Takada, S; Yamamoto, C | 1 |
| Crooks, SL; Freund, RK; Johnson, RL; Koerner, JF | 1 |
| Larder, AP; McLennan, H | 1 |
| Van Harreveld, A | 1 |
| Bodnarenko, SR; Chalupa, LM; Jeyarasasingam, G | 1 |
| Miller, RF; Thoreson, WB | 1 |
| Herrera, AJ; Osborne, NN | 1 |
| Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG | 1 |
| Adler-Graschinsky, E; Butta, NV; Lorenzo, PS | 1 |
| Hansson, E; Johansson, BB; Rönnbäck, L; Westergren, I | 1 |
| Brotchie, JM; East, SJ; Hill, MP | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Haldeman, B; Hampson, DR; Mulvihill, ER; Pickering, DS; Suzdak, PD; Thomsen, C | 1 |
| Bau, A; Faarup, P; Foged, C; Kanstrup, A; Suzdak, PD; Thomsen, C | 1 |
| Duvoisin, RM; Ramonell, K; Zhang, C | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 1 |
| Bigl, V; Grantyn, R; Rothe, T | 1 |
| Bodnarenko, SR; Chalupa, LM | 1 |
| Cotman, CW; Kahle, JS | 1 |
| Budd, DC; Herrero, I; Nicholls, DG; Sánchez-Prieto, J; Vázquez, E | 1 |
| Euler, T; Schneider, H; Wässle, H | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Cox, BM; Noble, F | 1 |
| Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; Minson, JB; Pilowsky, PM | 1 |
| Dowling, JE; Grant, GB | 1 |
| Copenhagen, DR; Dixon, DB | 1 |
| Bisti, S; Chalupa, LM; Gargini, C | 1 |
| Connaughton, VP; Nelson, R | 1 |
| Evans, DI; Jones, RS; Woodhall, G | 1 |
| Battaglia, G; Bruno, V; Catania, MV; Flor, PJ; Gasparini, F; Giuffrida, R; Hampson, DR; Inderbitzin, W; Ksiazek, I; Kuhn, R; Leonhardt, T; Lukic, S; Nicoletti, F; van der Putten, H | 1 |
| Awatramani, GB; Slaughter, MM | 1 |
| Oliet, SH; Piet, R; Poulain, DA | 1 |
| Bradley, SR; Conn, PJ; Marino, MJ; Wittmann, M | 1 |
| Abraini, JH; David, HN | 1 |
| Ikeda, SR; Kammermeier, PJ | 1 |
| Boahen, K; Demb, JB; Zaghloul, KA | 1 |
| Castro, E; Millán, C; Sánchez-Prieto, J; Shigemoto, R; Torres, M | 1 |
| Enyu, L; Hongmin, B; Xiang, Z; Zhou, F | 1 |
| Duty, S; MacInnes, N; Messenger, MJ | 1 |
| Baker, DA; Kalivas, PW; Shen, H; Xi, ZX | 1 |
| Ebert, B; Madsen, U; Vestergaard, HT; Vogensen, SB | 1 |
| Argiolas, A; Cortis, L; Mascia, MS; Melis, MR; Succu, S | 1 |
| Cohen, ED; Dowling, JE; Wong, KY | 1 |
| Oliet, SH; Panatier, A; Poulain, DA | 1 |
| Bush, RA; Hiriyanna, KT; Jamison, JA; Khan, NW; Kondo, M; Sieving, PA | 1 |
| Bisti, S; Chalupa, LM; Deplano, S; Gargini, C; Maccarone, R | 1 |
| de Novellis, V; Maione, S; Marabese, I; Mariani, L; Palazzo, E; Rodella, L; Rossi, F; Siniscalco, D | 1 |
| Cherubini, E; Conti, F; Fattorini, G; Safiulina, VF | 1 |
| Bai, D; Gong, XQ; Zabek, RL | 1 |
| Bamberg, E; Betz, H; Caldwell, JH; Herin, GA; Nagel, G; Scheschonka, A | 1 |
| Bartolomé-Martín, D; Ladera, C; Martín, R; Sánchez-Prieto, J; Torres, M | 1 |
| Bidziński, A; Hamed, A; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Sobolewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Wisłowska-Stanek, A | 1 |
| Acher, F; Barabino, E; Beurrier, C; Cuomo, D; Goudet, C; Gubellini, P; Kerkerian-Le Goff, L; Madeo, G; Martella, G; Melon, C; Oueslati, N; Pin, JP; Pisani, A; Platania, P; Selvam, C; Vita, D | 1 |
| Austin, PJ; Betts, MJ; Broadstock, M; Duty, S; Mitchell, SN; O'Neill, MJ | 1 |
| Takemoto, Y | 1 |
| Atwell, S; Chen, Q; Hao, J; Ho, JD; Monn, JA; Schkeryantz, JM; Vargas, MC; Wang, J; Zhang, A | 1 |
| Hofmann, CS; Lei, X; Niswender, CM; Rodriguez, AL | 1 |
| Allgeier, H; Knöpfel, T; Kuhn, R | 1 |
| Gilbert, TA; Haldeman, B; Hampson, DR; O'Hara, P; Pekhletski, R; Thomsen, C | 1 |
| Laurie, DJ; Schoeffter, P; Sommer, B; Wiederhold, KH | 1 |
| Ahmadian, H; Bräuner-Osborne, H; Johansen, TN; Krogsgaard-Larsen, P; Madsen, U; Nakanishi, S; Nielsen, B; Sekiyama, N; Sløk, FA; Stensbøl, TB | 1 |
| Arnold, JS; Belagaje, RM; Burgett, SG; Johnson, BG; Rockey, PK; Rosteck, PR; Schoepp, DD; Wright, RA; Wu, S | 1 |
| Hampson, DR; Han, G | 1 |
| Faull, RL; Kratzeisen, C; Lundstrom, K; Malherbe, P; Mutel, V; Richards, JG | 1 |
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Arnold, MB; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA | 1 |
| Acher, FC; Bertrand, HO; Bessis, AS; Pin, JP | 1 |
| Amori, L; Costantino, G; Diaz, MG; Hermit, MB; Marinozzi, M; Pellicciari, R; Serpi, M; Thomsen, C | 1 |
| Amori, L; Costantino, G; Flor, PJ; Gasparini, F; Gavilan Diaz, M; Giorgi, G; Heckendorn, R; Hermit, MB; Kuhn, R; Marinozzi, M; Meyer, U; Pellicciari, R; Serpi, M; Thomsen, C | 1 |
| Carmela Fulco, M; Christoffersen, CT; de Caprariis, P; Filosa, R; Giacchè, N; Macchiarulo, A; Marinozzi, M; Massa, A; Peduto, A; Pellicciari, R; Thomsen, C | 1 |
| Goudet, C; Jubault, P; Lemonnier, G; Lion, C; Pin, JP; Quirion, JC | 1 |
| Goudet, C; Ivashkin, P; Jubault, P; Lemonnier, G; Pannecoucke, X; Pin, JP; Tora, AS | 1 |
| Assaf, Z; Bjørn-Yoshimoto, WE; Brodbeck, R; Bunch, L; Erichsen, MN; Gefflaut, T; Goudet, C; Huynh, TH; Nielsen, B; Pin, JP; Sagot, E; Stensbøl, TB; Thomsen, C; Tora, AS | 1 |
4 review(s) available for 2-amino-4-phosphonobutyric acid and glutamic acid
| Article | Year |
|---|---|
Excitatory receptors and their role in excitotoxicity.
Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
Metabotropic glutamate receptors: novel targets for drug development.
Topics: Animals; Cloning, Molecular; Drug Design; Humans; Receptors, Metabotropic Glutamate | 1995 |
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
114 other study(ies) available for 2-amino-4-phosphonobutyric acid and glutamic acid
| Article | Year |
|---|---|
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1992 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
(2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Brain; Cell Line; Cell Membrane; Cyclopropanes; Glutamic Acid; Glycine; Humans; Isotope Labeling; Ligands; Rats; Receptors, Metabotropic Glutamate; Tritium | 2005 |
Mechanisms of glutamate activation of axon-to-Schwann cell signaling in the squid.
Topics: Aminobutyrates; Animals; Axons; Calcium; Chlorides; Decapodiformes; Egtazic Acid; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Membrane Potentials; Schwann Cells; Signal Transduction; Sodium; Tetrodotoxin; Time Factors; Tubocurarine | 1992 |
APB suppresses synaptic input to retinal horizontal cells in fish: a direct action on horizontal cells modulated by intracellular pH.
Topics: Aminobutyrates; Animals; Glutamates; Glutamic Acid; Goldfish; Hydrogen-Ion Concentration; Intracellular Membranes; Neural Inhibition; Retina; Sodium Chloride; Stereoisomerism | 1992 |
Trans-ACPD and L-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA).
Topics: Aminobutyrates; Amygdala; Animals; Cycloleucine; Electrodes; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1992 |
Energy requirements of glutamatergic pathways in rabbit retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Energy Metabolism; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kainic Acid; Light; Oxygen Consumption; Quinoxalines; Rabbits; Retina | 1992 |
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase.
Topics: Adenylyl Cyclases; Aminobutyrates; Animals; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Glutamates; Glutamic Acid; Kidney; Receptors, Glutamate | 1992 |
N-methyl-D-aspartate (NMDA) and non-NMDA (metabotropic) type glutamate receptors modulate the membrane potential of the Schwann cell of the squid giant nerve fibre.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Axons; Decapodiformes; Dipeptides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Quinoxalines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schwann Cells | 1992 |
Glutamate and 2-amino-4-phosphonobutyrate evoke an increase in potassium conductance in retinal bipolar cells.
Topics: Ambystoma; Aminobutyrates; Animals; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Membrane Potentials; Potassium; Potassium Channels; Retina | 1991 |
Autoradiographic characterization of [3H]L-glutamate binding sites in developing mouse cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Binding, Competitive; Calcium; Cerebellar Cortex; Chlorides; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Mice; N-Methylaspartate; Protein Binding; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1991 |
Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells.
Topics: 1-Methyl-3-isobutylxanthine; Aminobutyrates; Animals; Cell Membrane; Cyclic GMP; Electric Conductivity; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Photoreceptor Cells; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Second Messenger Systems; Thionucleotides; Urodela | 1990 |
Responses of rod bipolar cells isolated from the rat retina to the glutamate agonist 2-amino-4-phosphonobutyric acid (APB).
Topics: Aminobutyrates; Animals; Calcium; Carrier Proteins; Cell Separation; Electric Conductivity; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Photoreceptor Cells; Protein Kinase C; Rats; Sodium-Calcium Exchanger | 1991 |
Ibotenate stimulates glutamate release from guinea pig cerebrocortical synaptosomes: inhibition by L-2-amino-4-phosphonobutyrate (L-AP4).
Topics: Aminobutyrates; Animals; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Guinea Pigs; Ibotenic Acid; In Vitro Techniques; Male; Neurotoxins; Neurotransmitter Agents; Oxazoles; Synaptosomes | 1990 |
Presynaptic glutamate/quisqualate receptors: effects on synaptosomal free calcium concentrations.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Calcium; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Male; Phosphoserine; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptosomes | 1990 |
Actions of excitatory amino acids on brisk ganglion cells in the cat retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Anesthesia; Animals; Aspartic Acid; Cats; Electrodes; Glutamates; Glutamic Acid; Ibotenic Acid; Iontophoresis; Kainic Acid; N-Methylaspartate; Photic Stimulation; Quisqualic Acid; Retinal Ganglion Cells | 1990 |
L-glutamate binding site on N18-RE-105 neuroblastoma hybrid cells is not coupled to an ion channel.
Topics: Aminobutyrates; Animals; Binding, Competitive; Calcium; Chlorides; Cystine; Electric Conductivity; Fluorescent Antibody Technique; Glutamates; Glutamic Acid; Hybrid Cells; Intermediate Filament Proteins; Ion Channels; Mice; Neuroblastoma; Neurofilament Proteins; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Tumor Cells, Cultured | 1988 |
L(+)-2-amino-4-phosphonobutyrate inhibits the release of both glutamate and dynorphin from guinea pig but not rat hippocampal mossy fiber synaptosomes.
Topics: Aminobutyrates; Animals; Dynorphins; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Peptide Fragments; Rats; Rats, Inbred Strains; Synaptosomes | 1989 |
Effects of CNQX, APB, PDA, and kynurenate on horizontal cells of the tiger salamander retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Light; Membrane Potentials; Photoreceptor Cells; Pipecolic Acids; Quinoxalines; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; Retina; Urodela | 1989 |
Roles of aspartate and glutamate in synaptic transmission in rabbit retina. II. Inner plexiform layer.
Topics: Aminobutyrates; Animals; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurons; Rabbits; Retina; Retinal Ganglion Cells; Synaptic Transmission | 1985 |
Pharmacological characterization of postsynaptic receptors for excitatory amino acids in Purkinje cell dendrites in the guinea pig cerebellum.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dendrites; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Purkinje Cells; Receptors, Neurotransmitter | 1985 |
2-Amino-4-phosphonobutyric acid selectively blocks two-way avoidance learning in the mouse.
Topics: Aminobutyrates; Animals; Avoidance Learning; Electroshock; Glutamates; Glutamic Acid; Learning; Light; Mice; Mice, Inbred DBA; Synaptic Transmission | 1985 |
Effect of glutamate analogues on brain tumor cell lines.
Topics: 2-Aminoadipic Acid; Aminobutyrates; Brain Neoplasms; Cell Division; Cell Line; Glioma; Glutamates; Glutamic Acid; Glutamine; Homocysteine; Medulloblastoma; Neuroglia; Sarcoma | 1985 |
The subcellular distribution of DL-[3H]2-amino-4-phosphonobutyrate binding sites in the rat brain.
Topics: Aminobutyrates; Animals; Binding Sites; Brain; Brain Chemistry; Female; Glutamates; Glutamic Acid; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Subcellular Fractions; Synaptic Membranes | 1985 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Binding of L-[3H]glutamate to fresh or frozen synaptic membrane and postsynaptic density fractions isolated from cerebral cortex and cerebellum of fresh or frozen canine brain.
Topics: Aminobutyrates; Animals; Calcium; Cerebellum; Cerebral Cortex; Chlorides; Dogs; Freezing; Glutamates; Glutamic Acid; Phosphorylation; Sodium; Synapses; Synaptic Membranes | 1986 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.
Topics: Age Factors; Aminobutyrates; Animals; Aspartic Acid; Drug Interactions; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Norepinephrine; Oxadiazoles; Oxazoles; Phosphatidylinositols; Phosphoserine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Amino Acid; Receptors, Cell Surface | 1986 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Grasshoppers; Kynurenine; Male; Membrane Potentials; Mice; Muscles; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures | 1986 |
Characterization of L-glutamate binding sites in rat spinal cord synaptic membranes: evidence for multiple chloride ion-dependent sites.
Topics: Aminobutyrates; Animals; Anions; Brain; Calcium; Cations; Chlorides; Diencephalon; Glutamates; Glutamic Acid; Kinetics; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sodium; Spinal Cord; Synaptic Membranes; Telencephalon | 1986 |
Chloride-dependent binding sites for L-[3H]glutamate on dendrodendritic synaptosomal membranes of rat olfactory bulb.
Topics: Aminobutyrates; Animals; Chlorides; Dendrites; Glutamates; Glutamic Acid; Male; Olfactory Bulb; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synaptic Membranes | 1986 |
Specific binding of L-[3H]-glutamic acid to rat substantia nigra synaptic membranes.
Topics: 2-Aminoadipic Acid; Aminobutyrates; Animals; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Kinetics; Male; Oxadiazoles; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Substantia Nigra; Synaptic Membranes | 1986 |
Excitatory amino acid receptor potency and subclass specificity of sulfur-containing amino acids.
Topics: Amino Acids, Sulfur; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Kainic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Retina; Sodium; Synaptic Membranes | 1987 |
Hippocampal cells primed with quisqualate are depolarized by AP4 and AP6, ligands for a putative glutamate uptake site.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Aminocaproates; Animals; Aspartic Acid; Electric Stimulation; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Norleucine; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1987 |
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Colchicine; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface | 1987 |
Utilization of the synthetic phosphagen cyclocreatine phosphate by a simple brain model during stimulation by neuroexcitatory amino acids.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Chick Embryo; Glutamates; Glutamic Acid; Homocysteine; Imidazolidines; Kainic Acid; Magnesium; N-Methylaspartate; Phosphocreatine | 1988 |
Characterisation of Na+-independent L-[3H]glutamate binding sites in human temporal cortex.
Topics: 2-Amino-5-phosphonovalerate; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Cell Membrane; Chlorides; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; Male; Middle Aged; Oxadiazoles; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Temporal Lobe | 1988 |
AP4 inhibits chloride-dependent binding and uptake of [3H]glutamate in rabbit retina.
Topics: Aminobutyrates; Animals; Chlorides; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotransmitter Uptake Inhibitors; Rabbits; Receptors, Glutamate; Receptors, Neurotransmitter; Retina; Synaptosomes | 1988 |
2-amino-4-phosphonobutyric acid and N-methyl-D-aspartate differentiate between "3H]glutamate and [3H] aspartate binding sites in bovine retina.
Topics: Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Cattle; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; N-Methylaspartate; Neurons; Retina; Synaptic Membranes | 1982 |
Lateral olfactory tract transmitter: glutamate, aspartate, or neither?
Topics: Aminobutyrates; Animals; Aspartic Acid; Central Nervous System; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotransmitter Agents; Olfactory Pathways; Rats | 1981 |
Structure--activity relationships of L-glutamate receptor ligands: role of the omega-acidic terminal.
Topics: Aminobutyrates; Animals; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Phosphoserine; Phosphothreonine; Rats; Receptors, Cell Surface; Receptors, Glutamate; Stereoisomerism; Structure-Activity Relationship; Synapses; Synaptic Transmission | 1982 |
Chloride and calcium ions separate L-glutamate receptor populations in synaptic membranes.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Calcium; Chlorides; Glutamates; Glutamic Acid; In Vitro Techniques; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Cell Surface; Receptors, Glutamate; Synaptic Membranes | 1983 |
Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus.
Topics: Aminobutyrates; Animals; Aspartic Acid; Electric Stimulation; Evoked Potentials; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Nerve Fibers; Neurons; Receptors, Cell Surface; Receptors, Glutamate; Synapses; Synaptic Transmission | 1983 |
Characterization of the binding of DL-[3H]-2-amino-4-phosphonobutyrate to L-glutamate-sensitive sites on rat brain synaptic membranes.
Topics: Aminobutyrates; Animals; Binding Sites; Brain; Calcium; Chlorides; Female; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Synaptic Membranes; Temperature | 1983 |
Antagonist activity of phosphorus-containing glutamate analogues in the perforant path.
Topics: Aminobutyrates; Animals; Depression, Chemical; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Male; Neural Pathways; Phosphoserine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Synaptic Transmission | 1984 |
Binding sites for L-glutamate in the central nervous system of the rat.
Topics: Aminobutyrates; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Corpus Striatum; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glutamate; Spinal Cord; Tissue Distribution | 1984 |
The nature of the chick's magnesium-sensitive retinal spreading depression.
Topics: 2-Aminoadipic Acid; Aminobutyrates; Animals; Chickens; Electrophysiology; Glutamates; Glutamic Acid; Magnesium; Male; Proline; Retina; Synaptic Transmission | 1984 |
Development and regulation of dendritic stratification in retinal ganglion cells by glutamate-mediated afferent activity.
Topics: Afferent Pathways; Aminobutyrates; Animals; Animals, Newborn; Cats; Glutamic Acid; Neuronal Plasticity; Retina; Retinal Ganglion Cells; Time Factors | 1995 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction | 1994 |
Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria.
Topics: Adrenergic Fibers; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Atrial Function; Electric Stimulation; Female; Glutamates; Glutamic Acid; Heart Atria; Heart Rate; In Vitro Techniques; Kainic Acid; Male; Muscarinic Antagonists; N-Methylaspartate; Norepinephrine; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar | 1994 |
Glutamate-induced swelling of single astroglial cells in primary culture.
Topics: Aminobutyrates; Animals; Animals, Newborn; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Extracellular Space; Glutamic Acid; GTP-Binding Proteins; Ion Channels; Neurotoxins; Pertussis Toxin; Potassium Channels; Rats; Receptors, Glutamate; Spectrometry, Fluorescence; Virulence Factors, Bordetella | 1994 |
Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes.
Topics: 4-Aminopyridine; Aminobutyrates; Animals; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Receptors, Metabotropic Glutamate; Synaptosomes | 1995 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Aminobutyrates; Animals; Binding, Competitive; Cell Line; Cell Membrane; Clone Cells; Cricetinae; Cyanobacteria Toxins; Dizocilpine Maleate; Glutamates; Glutamic Acid; Ibotenic Acid; Inositol Phosphates; Kidney; Kinetics; Neurotoxins; Pertussis Toxin; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1993 |
Effects of bromohomoibotenate on metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kidney; Membranes; Phosphatidylinositols; Quinoxalines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb.
Topics: Amino Acid Sequence; Aminobutyrates; Animals; Base Sequence; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA Primers; DNA, Complementary; Gene Expression; Gene Library; Glutamic Acid; In Situ Hybridization; Mice; Molecular Sequence Data; Multigene Family; Olfactory Bulb; Polymerase Chain Reaction; Receptors, Metabotropic Glutamate; Recombinant Proteins; Retina; RNA, Messenger; Sequence Homology, Amino Acid; Transfection | 1995 |
Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals.
Topics: Alanine; Aminobutyrates; Animals; Cerebral Cortex; Diglycerides; Exocytosis; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Pertussis Toxin; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; Synaptosomes; Virulence Factors, Bordetella | 1994 |
Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice.
Topics: Alanine; Aminobutyrates; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Fluid; Mice; omega-Conotoxin GVIA; Organophosphorus Compounds; Peptides; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells | 1994 |
Stratification of ON and OFF ganglion cell dendrites depends on glutamate-mediated afferent activity in the developing retina.
Topics: Aminobutyrates; Animals; Cats; Cell Count; Dendrites; Glutamates; Glutamic Acid; Photoreceptor Cells; Retina; Retinal Ganglion Cells | 1993 |
L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.
Topics: Aminobutyrates; Animals; Atropine; Baclofen; Carbachol; Cycloleucine; Depression, Chemical; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neural Pathways; Neurotransmitter Uptake Inhibitors; Picrotoxin; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Theophylline | 1993 |
Co-existence and interaction between facilitatory and inhibitory metabotropic glutamate receptors and the inhibitory adenosine A1 receptor in cerebrocortical nerve terminals.
Topics: Adenosine; Aminobutyrates; Animals; Calcium; Cerebral Cortex; Excitatory Amino Acid Agonists; Exocytosis; Fura-2; Glutamic Acid; In Vitro Techniques; Nerve Endings; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Receptors, Purinergic P1; Synaptosomes | 1995 |
Glutamate responses of bipolar cells in a slice preparation of the rat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Kainic Acid; Rats; Retina | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
On bipolar cell responses in the teleost retina are generated by two distinct mechanisms.
Topics: Aminobutyrates; Animals; Bass; Cell Polarity; Chloride Channel Agonists; Electric Conductivity; Excitatory Amino Acid Agonists; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Isoquinolines; Patch-Clamp Techniques; Photoreceptor Cells; Retina; Retinal Rod Photoreceptor Cells | 1996 |
Metabotropic glutamate receptor-mediated suppression of an inward rectifier current is linked via a cGMP cascade.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Triphosphate; Aminobutyrates; Animals; Atrial Natriuretic Factor; Benzoates; Cyclic GMP; Enzyme Inhibitors; Glutamic Acid; Glycine; Ictaluridae; Ion Channel Gating; Isoquinolines; Models, Neurological; Patch-Clamp Techniques; Photoreceptor Cells; Potassium Channels; Receptors, Metabotropic Glutamate; Second Messenger Systems; Thionucleotides | 1997 |
Blockade of glutamate-mediated activity in the developing retina perturbs the functional segregation of ON and OFF pathways.
Topics: Aminobutyrates; Animals; Cats; Dendrites; Electrophysiology; Excitatory Amino Acid Agonists; Geniculate Bodies; Glutamic Acid; Photic Stimulation; Retina; Retinal Ganglion Cells | 1998 |
Axonal stratification patterns and glutamate-gated conductance mechanisms in zebrafish retinal bipolar cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Axons; Chlorides; Cycloleucine; Dendrites; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Neurons; Picrotoxin; Retina; Strychnine; Zebrafish | 2000 |
Activation of presynaptic group III metabotropic receptors enhances glutamate release in rat entorhinal cortex.
Topics: Aminobutyrates; Animals; Cyclopentanes; Dose-Response Relationship, Drug; Entorhinal Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; Male; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tricarboxylic Acids | 2000 |
Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.
Topics: Aminobutyrates; Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Heterozygote; Mice; Mice, Knockout; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Receptors, Metabotropic Glutamate; Stereoisomerism | 2000 |
Origin of transient and sustained responses in ganglion cells of the retina.
Topics: Ambystoma; Aminobutyrates; Animals; Darkness; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; In Vitro Techniques; Light; Membrane Potentials; Patch-Clamp Techniques; Photic Stimulation; Reaction Time; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells; Synaptic Transmission | 2000 |
Control of glutamate clearance and synaptic efficacy by glial coverage of neurons.
Topics: Amino Acid Transport System X-AG; Aminobutyrates; Animals; Astrocytes; ATP-Binding Cassette Transporters; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Lactation; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Supraoptic Nucleus; Synapses; Synaptic Transmission | 2001 |
Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amino Acids; Aminobutyrates; Animals; Bicuculline; Drug Design; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Nerve Tissue Proteins; Patch-Clamp Techniques; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Substantia Nigra; Xanthenes | 2001 |
The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D1-like, but not D2-like, dopamine receptors in the rat nucleus accumbens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminobutyrates; Animals; Benzoates; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Motor Activity; Neurons; Nucleus Accumbens; Proline; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Synaptic Transmission | 2001 |
Metabotropic glutamate receptor expression in the rat superior cervical ganglion.
Topics: Aminobutyrates; Animals; Brain; DNA Primers; Excitatory Amino Acid Agonists; Glutamic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Receptors, Metabotropic Glutamate; RNA, Messenger; Superior Cervical Ganglion | 2002 |
Different circuits for ON and OFF retinal ganglion cells cause different contrast sensitivities.
Topics: Action Potentials; Afferent Pathways; Aminobutyrates; Animals; Contrast Sensitivity; Culture Techniques; Glutamic Acid; Guinea Pigs; Kinetics; Membrane Potentials; Models, Neurological; Neural Inhibition; Photic Stimulation; Retinal Cone Photoreceptor Cells; Retinal Ganglion Cells; Synaptic Transmission | 2003 |
Co-expression of metabotropic glutamate receptor 7 and N-type Ca(2+) channels in single cerebrocortical nerve terminals of adult rats.
Topics: Aminobutyrates; Animals; Calcium; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cerebral Cortex; Diagnostic Imaging; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Nerve Endings; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 2003 |
Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.
Topics: Aminobutyrates; Animals; Behavior, Animal; Brain; Brain Injuries; Cell Count; Cognition Disorders; Diffuse Axonal Injury; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Movement Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger; Synaptic Transmission; Treatment Outcome | 2003 |
Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat.
Topics: Aminobutyrates; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Globus Pallidus; Glutamic Acid; Hypokinesia; Injections, Intraventricular; Injections, Subcutaneous; Male; Movement; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reserpine; Rotation; Substantia Nigra | 2004 |
Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens.
Topics: Aminobutyrates; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; Glutamic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 2003 |
Analogues of homoibotenic acid show potent and selective activity following sensitisation by quisqualic acid.
Topics: Aminobutyrates; Animals; Calcium Chloride; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Male; Neurons; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Synaptosomes | 2004 |
Extracellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of N-methyl-d-aspartic acid receptors in erectile function.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Analysis of Variance; Animals; Aspartic Acid; Behavior, Animal; Copulation; Dialysis; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Penile Erection; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sexual Behavior, Animal | 2004 |
Retinal bipolar cell input mechanisms in giant danio. II. Patch-clamp analysis of on bipolar cells.
Topics: Aminobutyrates; Animals; Aspartic Acid; Barium; D-Aspartic Acid; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Kainic Acid; Light; Membrane Potentials; Neurons; Patch-Clamp Techniques; Photic Stimulation; Potassium Channel Blockers; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Tetraethylammonium; Time Factors; Visual Pathways; Zebrafish | 2005 |
Regulation of transmitter release by high-affinity group III mGluRs in the supraoptic nucleus of the rat hypothalamus.
Topics: Aminobutyrates; Animals; Benzoates; Cyclopentanes; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Supraoptic Nucleus; Synaptic Transmission; Tricarboxylic Acids | 2004 |
Primate Retinal Signaling Pathways: Suppressing ON-Pathway Activity in Monkey With Glutamate Analogues Mimics Human CSNB1-NYX Genetic Night Blindness.
Topics: Adolescent; Adult; Aminobutyrates; Animals; DNA Mutational Analysis; Dose-Response Relationship, Radiation; Drug Interactions; Electroretinography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Macaca mulatta; Male; Middle Aged; Mutation; Night Blindness; Photic Stimulation; Pipecolic Acids; Proteoglycans; Retina; Visual Pathways | 2005 |
Long-term treatment of the developing retina with the metabotropic glutamate agonist APB induces long-term changes in the stratification of retinal ganglion cell dendrites.
Topics: Aminobutyrates; Animals; Animals, Newborn; Cats; Cell Differentiation; Dendrites; Excitatory Amino Acid Agonists; Glutamic Acid; Horseradish Peroxidase; Immunohistochemistry; Neural Pathways; Neuronal Plasticity; Receptors, Metabotropic Glutamate; Retina; Retinal Ganglion Cells | 2004 |
Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level.
Topics: Alanine; Aminobutyrates; Analysis of Variance; Animals; Benzoates; Colforsin; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Immunohistochemistry; Isoquinolines; Male; Microdialysis; Microscopy, Immunoelectron; Periaqueductal Gray; Phosphoserine; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sulfonamides; Time Factors | 2005 |
GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.
Topics: Action Potentials; Aminobutyrates; Animals; Animals, Newborn; Bicuculline; Cation Transport Proteins; Dentate Gyrus; Electric Stimulation; Excitatory Amino Acid Agonists; Flurazepam; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons; Mossy Fibers, Hippocampal; Nipecotic Acids; Oximes; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Propanolamines; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Receptors, AMPA; Receptors, GABA-A; Synaptic Transmission; Vesicular Glutamate Transport Protein 1 | 2006 |
D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons.
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Molecular Structure; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Valine | 2007 |
Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7.
Topics: Algal Proteins; Aminobutyrates; Animals; Calcium; Calcium Signaling; Calmodulin; Chelating Agents; Chlamydomonas reinhardtii; Depression; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Gene Expression; Glutamic Acid; Humans; Light; Long-Term Potentiation; Oocytes; Receptors, Metabotropic Glutamate; Recombinant Proteins; Rhodopsin; Synapses; Xenopus | 2008 |
Partial compensation for N-type Ca(2+) channel loss by P/Q-type Ca(2+) channels underlines the differential release properties supported by these channels at cerebrocortical nerve terminals.
Topics: 4-Aminopyridine; Aminobutyrates; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Cerebral Cortex; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Exocytosis; Gene Knockout Techniques; Glutamic Acid; Mice; Oligonucleotides, Antisense; Phorbol Esters; Potassium Channel Blockers; Presynaptic Terminals; Receptors, Metabotropic Glutamate; Synaptosomes | 2009 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Receptors, Metabotropic Glutamate; Taurine | 2009 |
Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.
Topics: Aminobutyrates; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Movement; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Sympatholytics; Synaptic Transmission; Tetrodotoxin | 2009 |
Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease.
Topics: Aminobutyrates; Animals; Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Parkinson Disease; Phosphoserine; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra | 2010 |
L-Cysteine and L-AP4 microinjections in the rat caudal ventrolateral medulla decrease arterial blood pressure.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Anesthetics; Animals; Arterial Pressure; Cardiovascular Agents; Cysteine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Microinjections; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Urethane | 2014 |
Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.
Topics: Aminobutyrates; Crystallography, X-Ray; Glutamic Acid; Humans; Ligands; Protein Binding; Protein Domains; Receptors, Metabotropic Glutamate; Recombinant Proteins | 2018 |
Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7.
Topics: Allosteric Regulation; Glutamic Acid | 2023 |
Cloning and characterization of a metabotropic glutamate receptor, mGluR4b.
Topics: Amino Acid Sequence; Aminobutyrates; Animals; Base Sequence; Cell Line; Cloning, Molecular; Cyclic AMP; Molecular Sequence Data; Rats; Receptors, Metabotropic Glutamate | 1997 |
Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Tissue Distribution | 1997 |
(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cyclic AMP; Excitatory Amino Acid Agonists; Hydrolysis; In Vitro Techniques; Magnetic Resonance Spectroscopy; Membrane Potentials; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Stereoisomerism | 1997 |
Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Cell Line; Cloning, Molecular; Colforsin; Consensus Sequence; Cyclic AMP; DNA, Complementary; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Mice; Molecular Sequence Data; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 1998 |
Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor.
Topics: Amino Acid Substitution; Binding Sites; Binding, Competitive; Cell Line; Dithiothreitol; DNA, Complementary; Humans; Ligands; Molecular Weight; Mutagenesis, Site-Directed; Protein Conformation; Receptors, Metabotropic Glutamate; Solubility | 1999 |
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.
Topics: Adult; Alternative Splicing; Animals; Blotting, Northern; Blotting, Southern; Brain Chemistry; CHO Cells; Cloning, Molecular; Cricetinae; DNA Probes; DNA, Complementary; Fetus; Gene Expression Regulation, Viral; Humans; In Situ Hybridization; Kidney; Molecular Sequence Data; Propionates; Receptors, Metabotropic Glutamate; RNA, Messenger; Semliki forest virus; Sequence Homology, Amino Acid; Transfection; Tritium | 1999 |
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
Topics: Amino Acids; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Substrate Specificity; Tritium; Xanthenes | 2000 |
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
Topics: Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Agonists; Glutamic Acid; Ligands; Models, Molecular; Receptors, Metabotropic Glutamate; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2002 |
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.
Topics: Animals; Cell Line; CHO Cells; Cricetinae; Glutamic Acid; Glycine; Kinetics; Ligands; Models, Chemical; Molecular Conformation; Propionates; Protein Binding; Protein Conformation; Receptors, Metabotropic Glutamate; Stereoisomerism | 2006 |
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Topics: Animals; Crystallography, X-Ray; Cyclopropanes; Drug Evaluation, Preclinical; Glycine; Humans; Ligands; Models, Molecular; Molecular Structure; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism; Structure-Activity Relationship | 2007 |
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands.
Topics: Alanine; Amino Acids, Acidic; Bridged Bicyclo Compounds; Glycine; Humans; Ligands; Pentanes; Protein Binding; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Topics: Carboxylic Acids; Cells, Cultured; Cyclopropanes; Dose-Response Relationship, Drug; Drug Design; Glutamic Acid; HEK293 Cells; Humans; Molecular Structure; Receptors, Metabotropic Glutamate; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2012 |
Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.
Topics: Carboxylic Acids; Cyclopropanes; Glutamic Acid; Protein Binding; Protein Isoforms; Receptors, Metabotropic Glutamate; Stereoisomerism | 2015 |
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; Glutamic Acid; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2016 |