2-amino-4-hydroxy-6-7-dimethyl-5-6-7-8-tetrahydropteridine and dihydroneopterin-triphosphate

2-amino-4-hydroxy-6-7-dimethyl-5-6-7-8-tetrahydropteridine has been researched along with dihydroneopterin-triphosphate* in 1 studies

Other Studies

1 other study(ies) available for 2-amino-4-hydroxy-6-7-dimethyl-5-6-7-8-tetrahydropteridine and dihydroneopterin-triphosphate

ArticleYear
Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
    Biochemistry, 2009, Mar-24, Volume: 48, Issue:11

    To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homologue possibly involved in queuosine biosynthesis. While mammalian PTPS homologues convert 7,8-dihydroneopterin triphosphate (H(2)NTP) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin biosynthesis, E. coli QueD catalyzes the conversion of H(2)NTP to 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)). E. coli QueD can also convert PPH(4) and sepiapterin to CPH(4), allowing a mechanism to be proposed.

    Topics: Carbon-Oxygen Lyases; Escherichia coli; Escherichia coli Proteins; Neopterin; Pteridines

2009