2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with quinoxalines in 353 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (11.33) | 18.7374 |
| 1990's | 163 (46.18) | 18.2507 |
| 2000's | 88 (24.93) | 29.6817 |
| 2010's | 58 (16.43) | 24.3611 |
| 2020's | 4 (1.13) | 2.80 |
| Authors | Studies |
|---|---|
| Jägerstad, M; Nielsen, LL; Nyman, M; Sjödin, P; Wallin, H | 1 |
| Klungsøyr, L; Mjelva, BB; Vikse, R | 1 |
| Akaike, T; Ando, M; Kojima, Y; Maeda, H; Nagao, M; Sato, K | 1 |
| Brams, A; de Meester, C | 1 |
| Alldrick, AJ; Brennan-Craddock, WE; Lake, BG; Rowland, IR | 1 |
| Alldrick, AJ; Coutts, TM; Ho, TA; Rowland, IR | 1 |
| Fay, LB; Turesky, RJ | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Knize, MG; Lynch, AM; Murray, S | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lewis, I; Murray, BP; Rendell, NB; Rich, KJ | 1 |
| Brandt, I; Brittebo, E; Eriksson, C; Gustafsson, JA; Overvik, E | 1 |
| Adamson, RH; Schut, HA; Snyderwine, EG; Thorgeirsson, SS; Thorgeirsson, UP | 1 |
| Felton, JS; Fultz, E; Knize, MG; Roper, M; Shen, NH; Turteltaub, KW | 1 |
| Ilett, KF; Kadlubar, FF; Minchin, RF; Reeves, PT; Teitel, CH | 1 |
| Alexander, J; Holme, JA; Wallin, H | 1 |
| Aune, T; Ingebrigtsen, K; Tjøtta, K | 1 |
| Kushida, H; Nagao, M; Sone, H; Sugimura, T; Wakabayashi, K | 1 |
| Bucci, T; Dooley, KL; Fu, PP; Kadlubar, FF; Von Tungeln, LS | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Rice, JC; Soames, A | 1 |
| Gustafsson, JA; Kleman, M; Mason, G; Overvik, E | 1 |
| Boncristiani, G; Loprieno, G; Loprieno, N | 2 |
| Hirose, M; Itoh, H; Nagao, M; Sugimura, T; Ushiyama, H; Wakabayashi, K | 1 |
| Butler, MA; Kadlubar, FF; Lang, NP; Teitel, CH; Turesky, RJ | 1 |
| Bracco-Hammer, I; Fay, LB; Markovic, J; Turesky, RJ | 1 |
| Hirose, M; Nagao, M; Ochiai, M; Overvik, E; Sugimura, T | 1 |
| Buonarati, MH; Davis, JC; Felton, JS; Gledhill, BL; Turteltaub, KW; Vogel, JS | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, A; Murray, BP; Murray, S; Sesardic, D | 1 |
| Esumi, H; Kudo, M; Ogura, T; Sugimura, T | 1 |
| Fukushima, S; Hakoi, K; Hasegawa, R; Ito, N; Iwasaki, S; Nagao, M; Shirai, T; Sugimura, T; Takaba, K; Wakabayashi, K | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, AM; Murray, S | 1 |
| Adachi, M; Kato, S; Nagao, M; Nakagama, H; Ochiai, M; Sato, S; Sugimura, T; Wakabayashi, K; Yamashita, K | 1 |
| Adamson, RH; Schut, HA; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Turesky, RJ | 1 |
| Baker, AJ; Gooderham, NJ; Morgan, JP; Srebernik, N | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Murray, BP; Murray, S | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Ponder, BA; Winton, DJ | 1 |
| Gooderham, NJ; O'Farrell, FJ | 1 |
| Ito, N; Ozaki, K; Takahashi, S; Tsuda, H; Yamaguchi, S | 1 |
| Burgess, WM; Huggett, A; McManus, ME; Quattrochi, LC; Tukey, RH; Veronese, ME | 1 |
| Caffee, MW; Davis, JC; Felton, JS; Finkel, RC; Gledhill, BL; Nelson, DE; Proctor, ID; Southon, JR; Turteltaub, KW; Vogel, JS | 1 |
| Jägerstad, M; Skog, K | 2 |
| Ayrton, AD; Flatt, PR; Ioannides, C; Keele, A; Lewis, DF; Walker, R | 1 |
| Felton, JS; Turteltaub, KW; Vanderlaan, M; Watkins, BE | 1 |
| Negishi, C; Sato, S; Yamaizumi, Z | 1 |
| Blanck, A; Gustafsson, JA; Kleman, M; Overvik, E | 1 |
| Aeschbacher, HU; Forster, CM; Skipper, PL; Tannenbaum, SR; Trudel, LJ; Turesky, RJ; Würzner, HP | 1 |
| Alexander, J; Jägerstad, M; Sjödin, P; Wallin, H | 1 |
| Alldrick, AJ; Lutz, WK | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Murray, S | 3 |
| Wada, O; Yanagisawa, H | 1 |
| Alexander, J; Becher, G; Holme, JA; Wallin, H | 1 |
| Aeschbacher, HU; Ruch, E | 1 |
| Ayrton, AD; Bass, SL; Flatt, PR; Ioannides, C; Trinick, J; Walker, R | 1 |
| Grivas, S; Kato, S; Sugimura, T; Umemoto, A; Yamashita, K | 1 |
| Hayatsu, H; Kato, T; Kikugawa, K | 1 |
| Abu-Zeid, M; Kato, R; Manabe, S; Toyama, S; Yamazoe, Y | 1 |
| Aeschbacher, HU; Bur, H; Huynh-Ba, T; Milon, H; Turesky, RJ | 1 |
| Alldrick, AJ; Rowland, IR | 1 |
| Alexander, J; Wallin, H | 1 |
| Kato, T; Kikugawa, K | 1 |
| Alldrick, AJ; Rowland, IR; Wise, A | 1 |
| Abu-Shakra, A; Ioannides, C; Walker, R | 1 |
| Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Sugimura, T; Takayama, S | 1 |
| Aeschbacher, HU; Malnoë, A; Turesky, RJ; Würzner, HP | 1 |
| Aeschbacher, HU; Skipper, PL; Tannenbaum, SR; Turesky, RJ; Würzner, HP | 1 |
| Liu, ZC; Nagao, M; Sugimura, T; Wakabayashi, K; Zhang, XM | 1 |
| Arimoto, S; Hayatsu, H; Hayatsu, T; Kasai, H; Miyazawa, T; Nishimura, S; Ohara, Y; Sato, S; Yamaizumi, Z; Yokoyama, S | 1 |
| Hasegawa, H; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S | 1 |
| Davies, DS; Gooderham, NJ; Murray, S; Rice, JC; Taylor, GW; Watson, D | 1 |
| Manabe, S; Wada, O; Yanagisawa, H | 1 |
| Beamand, JA; Howes, AJ; Rowland, IR | 1 |
| Ishikawa, S; Kitagawa, Y; Manabe, S; Nakajima, K; Wada, O; Yanagisawa, H | 1 |
| Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S | 1 |
| Caderni, G; Dolara, P; Salvadori, M; Santoni, G | 1 |
| Grivas, S; Olsson, K | 1 |
| Goto, T; Kinae, N; Masui, T; Nagao, M; Sugimura, T; Takahashi, M; Tomita, I; Wakabayashi, K; Yamamoto, M | 1 |
| Hayatsu, H; Hayatsu, T; Matsui, Y; Ohara, Y; Oka, T | 1 |
| Grivas, S; Jägerstad, M; Negishi, C; Olsson, K; Sato, S; Sugimura, T; Tsuda, M; Wakabayashi, K | 1 |
| Buchi, GH; Pfund, RA; Tannenbaum, SR; Turesky, RJ; Wishnok, JS | 1 |
| Hayashi, K; Kasai, H; Miyazawa, T; Nishimura, S; Watanabe, T; Yokoyama, S | 1 |
| Diachenko, GW; Hargraves, WA; Jackson, LS; Stroup, WH | 1 |
| Brown, ED; Davies, DS; Hoover, RN; Kadlubar, FF; Lang, NP; Levander, OA; Mark, SD; Murray, S; Rothman, N; Sinha, R | 1 |
| Sadrieh, N; Snyderwine, EG | 1 |
| Hirose, M; Kushida, H; Nagao, M; Ochiai, M; Sato, H; Sugimura, T; Wakabayashi, K | 1 |
| Deguchi, T; Hashimoto, H; Itoh, S; Kamataki, T; Sawada, M; Yanagawa, Y | 1 |
| Brown, ED; Cunningham, PL; Felton, JS; Knize, MG; Levander, OA; Rothman, N; Salmon, CP; Sinha, R | 1 |
| Robertson, JA; Ryden, P | 2 |
| Hao, NJ; Lee, H; Lin, MY | 1 |
| Sasaki, YF; Shirasu, Y | 1 |
| Ferguson, LR; Harris, PJ; Roberton, AM; Triggs, CM; Watson, ME | 1 |
| Kato, R; Nagata, K; Ozawa, S; Yamazoe, Y | 1 |
| Wild, D | 1 |
| Davis, CD; Fay, LB; Snyderwine, EG; Turesky, RJ; Welti, DH | 1 |
| Bangerter, C; Frantz, CE; Fultz, E; Mayer, KM; Turteltaub, KW; Vogel, JS | 1 |
| Brown, ED; Caporaso, NE; Hoover, RN; Kadlubar, FF; Knize, MG; Lang, NP; Levander, OA; Mark, SD; Rothman, N; Sinha, R | 1 |
| Dolbeare, FA; Felton, JS; Fultz, E; Knize, MG | 1 |
| Deguchi, T; Gonzalez, FJ; Kamataki, T; Sawada, M; Yanagawa, Y | 1 |
| Carroll, KL; Dolbeare, FA; Felton, JS; Knize, MG; Moore, DH | 1 |
| Jägerstad, M; Johansson, MA | 1 |
| Chiarelli, MP; Kaderlik, KR; Kadlubar, FF; Lang, NP; Mulder, GJ; Teitel, CH; Turesky, RJ | 1 |
| Nagao, M; Oguri, A; Wakabayashi, K; Weisburger, JH | 1 |
| Katami, M; Kurosaka, R; Kushida, H; Nagao, M; Sato, H; Wakabayashi, K | 1 |
| Kadlubar, FF; Ketterer, B; Lang, NP; Lin, D; Meyer, DJ | 1 |
| Boobis, AR; Brooks, RA; Edwards, RJ; Gooderham, NJ; Howard, LA; Winton, DJ; Zhao, K | 1 |
| Boobis, AR; Davies, DS; Edwards, RJ; Gant, TW; Murray, BP; Murray, S; Neubert, D; Schulz, T; Thorgeirsson, SS | 1 |
| Burgard, S; Edenharder, R; John, K; Kurz, P; Seeger, K | 1 |
| Adamson, RH; Davis, CD; Snyderwine, EG | 1 |
| Davis, CD; Schut, HA; Snyderwine, EG | 1 |
| Blanck, A; Gustafsson, JA; Kleman, MI; Overvik, E; Porsch-Hällström, I | 1 |
| Kim, SB; Nagao, M; Nagaoka, H; Nukaya, H; Ochiai, M; Sugimura, T; Tada, A; Tanaka, Y; Wakabayashi, K | 1 |
| Ghoshal, A; Snyderwine, EG | 1 |
| Fay, LB; Gross, GA; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ | 1 |
| Shubik, P | 1 |
| Boobis, AR; Davies, DS; de la Torre, R; Farré, M; Gooderham, NJ; Lynch, AM; Murray, S; Segura, J; Solans, A | 1 |
| Banning, DP; Gooderham, NJ; O'Farrell, F | 1 |
| Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ | 1 |
| Hirose, M; Kim, SB; Nagao, M; Nukaya, H; Ochiai, M; Sugimura, T; Takahashi, M; Ushiyama, H; Wakabayashi, K | 1 |
| Djanegara, T; Hwang, M; Vanderlaan, M | 1 |
| Davis, CD; Nouso, K; Roller, PP; Schut, HA; Snyderwine, EG | 1 |
| Alldrick, AJ; Hô, TA; Phillips, DH; Rowland, IR; She, MN | 1 |
| Gooderham, MJ; Knize, MG; Lynch, AM; Murray, S | 1 |
| Gustafsson, JA; Hellmold, H; Overvik, E; Strömstedt, M | 1 |
| Kushida, H; Nagao, M; Ochiai, M; Sone, H; Sugimura, T; Wakabayashi, K | 1 |
| Adamson, RH; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS; Thorgeirsson, UP | 1 |
| Jägerstad, M; Johansson, M; Skog, K | 2 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, AM; Murray, S; Zhao, K | 1 |
| Bohr, VA; Nouso, K; Schut, HA; Snyderwine, EG | 1 |
| Guigoz, Y; Honegger, P; Juillerat, M; Schilter, B; Turesky, RJ | 1 |
| Alexander, J; Ingebrigtsen, K; Klungsøyr, L; Vikse, R | 1 |
| Alldrick, AJ; Brennan-Craddock, WE; Rowland, IR | 1 |
| Enomoto, K; Kushida, H; Mori, M; Nagao, M; Sone, H; Sugimura, T; Takeichi, N; Tsuda, H; Wakabayashi, K | 1 |
| Cui, L; Hasegawa, R; Hirose, M; Ito, N; Kato, T; Kobayashi, Y; Konishi, Y; Nakae, D; Shirai, T; Yaono, M | 1 |
| Boobis, AR; Davies, DS; Gooderham, NJ; Rich, KJ; Zhao, K | 1 |
| Fukutome, K; Sugimura, T; Tada, A; Takahashi, M; Takahashi, S; Totsuka, Y; Wakabayashi, K | 1 |
| Hayatsu, H; Negishi, T; Shinoda, A; Sugiyama, C | 1 |
| Boobis, AR; Davies, DS; de la Torre, R; Gooderham, NJ; Lynch, A; Murray, S; Segura, J | 2 |
| Boobis, AR; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, S; Yadollahi-Farsani, M | 1 |
| Adamson, RH; Sugimura, T; Thorgeirsson, UP | 1 |
| Essigmann, JM; Morgenthaler, PM; Solomon, MS; Turesky, RJ | 1 |
| Nagao, M; Sugimura, T; Totsuka, Y; Toyota, M; Ushijima, T; Wakabayashi, K | 1 |
| Bhadresa, S; Boobis, AR; Bratt, C; Crosbie, SJ; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, BP; Murray, S; Rich, KJ; Yadollahi-Farsani, M; Zhao, K | 1 |
| Boobis, AR; Gooderham, NJ; Lynch, AM; Murray, S | 1 |
| Dacquel, EJ; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS | 1 |
| Grivas, S | 1 |
| Cunningham, PL; Dolbeare, FA; Felton, JS; Knize, MG | 1 |
| Fay, LB; Turesky, RJ; Welti, DH | 1 |
| Adamson, RH; Buonarati, MH; Snyderwine, EG; Turesky, RJ; Turteltaub, KW | 1 |
| Adamson, RH; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS | 1 |
| Felton, JS; Frantz, C; McManus, M; Turteltaub, KW; Vogel, JS | 1 |
| Akaike, T; Maeda, H; Sato, K | 1 |
| Branting, C; Gustafsson, JA; Hellmold, H; Overvik, E | 1 |
| Boobis, AR; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, BP; Murray, S; Rich, KJ; Zhao, K | 1 |
| Gross, GA; Henderson, BE; Ji, H; Ross, RK; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ; Yu, MC | 1 |
| Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R | 1 |
| Adamson, RH; Dalgard, DW; Thorgeirsson, UP | 1 |
| Inoue, R; Kakiuchi, H; Makino, H; Nagao, M; Sugimura, T; Ushijima, T | 1 |
| Breneman, JW; Briner, JF; Director, A; Ramsey, MJ; Tucker, JD | 1 |
| Heiniö, RL; Latva-Kala, KJ; Tikkanen, LM | 1 |
| Sugimura, T | 1 |
| Felton, JS; Hopmans, EC; Knize, MG; Salmon, CP | 1 |
| Kristiansen, E; Meyer, O; Thorup, I | 1 |
| Felton, JS; Knize, MG; Salmon, CP | 2 |
| Kidd, LC; Sinha, R; Stillwell, WG; Tannenbaum, SR; Wishnok, JS | 1 |
| Ohe, T | 1 |
| Augustsson, K; Jägerstad, M; Skog, K; Steineck, G | 1 |
| Akasaka, M; Matsusaka, N; Nishidate, E; Ohta, T; Saga, A; Sasaki, YF; Tsuda, S; Watanabe-Akanuma, M | 1 |
| Jenq, SN; Lee, H; Yang, CC | 1 |
| Futakuchi, M; Hirose, M; Ito, T; Miki, T; Orita, SI; Shirai, T; Tanaka, H | 1 |
| Kaneko, T; Meguro, S; Terahara, M | 1 |
| Dingley, KH; Fay, LB; Garner, RC; Leveson, SH; Richoz, J; Turesky, RJ; Turteltaub, KW; Welti, DH | 1 |
| Grunnet, N; Knudsen, LE; Møller, P; Risom, L; Wallin, H | 1 |
| Furukawa, F; Ikezaki, S; Kasahara, K; Kim, HC; Nishikawa, A; Takahashi, M; Tanakamaru, Z | 1 |
| Barton, PT; Beamand, JA; Lake, BG; Price, RJ; Tredger, JM | 1 |
| Oguri, A; Suda, M; Sugimura, T; Totsuka, Y; Wakabayashi, K | 1 |
| Dingley, KH; Freeman, SP; Garner, RC; Nelson, DO; Turteltaub, KW | 1 |
| Constable, A; Guengerich, FP; Markovic, J; Martin, MV; Richoz, J; Turesky, RJ; Varga, N | 1 |
| Jägerstad, M; Skog, K; Vereskuns, G; Wesén, C | 1 |
| Dingley, KH; Turteltaub, KW | 1 |
| Cole, KJ; Grover, PL; Marquardt, H; Martin, FL; Pfau, W; Phillips, DH; Venitt, S | 1 |
| Henderson, BE; Kidd, LC; Ross, RK; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Wishnok, JS; Yu, MC | 1 |
| Kawanishi, S; Kobayashi, M; Murata, M | 1 |
| Aryal, P; Guengerich, FP; Oda, Y; Shimada, T; Terashita, T; Yoshikawa, K | 1 |
| Furukawa, F; Hirose, M; Kasahara, K; Miyauchi, M; Nakamura, H; Nishikawa, A; Takahashi, M | 1 |
| Archer, C; Debiec-Rychter, M; Haas, GP; Jones, RF; King, CM; Morse, P; Schut, HA; Wang, CY | 1 |
| Adamson, RH; Dalgard, DW; Ogawa, K; Ogiso, T; Shirai, T; Sugimura, T; Thorgeirsson, SS; Thorgeirsson, UP; Tsuda, H; Wakabayashi, K | 1 |
| Fujita, K; Iwata, H; Kamataki, T; Kushida, H; Nohmi, T; Suzuki, A; Watanabe, M | 1 |
| Akaike, T; Maeda, H; Sawa, T; Yubisui, T | 1 |
| Sinha, R; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ | 1 |
| Curtis, KD; Dingley, KH; Felton, JS; Garner, RC; Lang, NP; Malfatti, MA; Turesky, RJ; Turteltaub, KW | 1 |
| Fukushima, S | 1 |
| Alexander, DJ; Coxhead, JM; Cupid, BC; Dingley, KH; Garner, RC; Kutschera, W; Leveson, SH; Lightfoot, TJ; Mauthe, RJ; Priller, A; Rom, W; Russell, D; Steier, P; Turteltaub, KW | 1 |
| Rothman, N; Sinha, R | 1 |
| Degawa, M; Konno, Y; Moore, MA; Nakashita, K; Sekine, K; Takasuka, N; Tsuda, H; Uehara, N | 1 |
| Ryu, DY; Snyderwine, EG; Thorgeirsson, SS; Weidner, V | 1 |
| Sinha, R; Stillwell, WG; Tannenbaum, SR; Turesky, RJ | 1 |
| Darroudi, F; Knasmüller, S; Kundi, M; Land, SJ; Parzefall, W; Sanyal, R; Schwab, CE; Wang, CY | 1 |
| Amanuma, H; Amanuma, K; Aoki, Y; Takeda, H | 1 |
| Anton-Culver, H; Butler, J; Delfino, RJ; Gim, JS; Liao, SY; Lin, HJ; Ma, HL; Sinha, R; Smith, C; West, J; White, E | 1 |
| Furukawa, F; Hayashi, M; Itoh, T; Nishikawa, A; Sofuni, T; Suzuki, T; Takahashi, M; Xue, W | 1 |
| Alavanja, MC; Brownson, RC; Curtin, J; Kulldorff, M; Sinha, R; Swanson, CA | 1 |
| Futakuchi, M; Hirose, M; Ito, N; Lin, C; Shirai, T; Thamavit, W; Tiwawech, D | 1 |
| Hirose, M; Kawabe, M; Kimoto, N; Lin, C; Sano, M; Shirai, T | 1 |
| Bogen, KT; Enns, L; Hall, LC; Keating, GA; Murphy, G; Panteleakos, FN; Weinfeld, M; Wu, RW | 1 |
| Fay, LB; Guengerich, FP; Guillouzo, A; Huynh-Ba, T; Kerriguy, N; Langouët, S; Markovic, J; Turesky, RJ; Welti, DH | 1 |
| Broyde, S; Gauvin, J; Shapiro, R | 1 |
| Amantana, A; Dashwood, RH; Orner, GA; Provost, C; Santana-Rios, G; Wu, SY | 1 |
| Guengerich, FP; Huynh-Ba, T; Langouët, S; Parisod, V; Turesky, RJ | 1 |
| Batty, SM; Boverhof, DR; Josephy, PD | 1 |
| Boobis, AR; Bowey, EA; Edwards, AJ; Gooderham, NJ; Gray, S; Lake, BG; Murray, S; Springall, C; Williamson, G | 1 |
| Furukawa, F; Mori, H; Mori, I; Nishikawa, A; Takahashi, M; Tanakamaru, Z | 1 |
| Amanuma, K; Aoki, Y; Saito, H; Shigeoka, T; Tone, S | 1 |
| Fay, LB; Guengerich, FP; Guillouzo, A; Kerriguy, N; Langouët, S; Turesky, RJ; Welti, DH | 1 |
| Furukawa, F; Hirose, M; Koide, A; Miyauchi, M; Mori, Y; Nishikawa, A; Okazaki, K; Son, HY | 1 |
| Fukushima, S; Iwai, S; Karim, R; Kitano, M; Min, W; Morimura, K; Seki, S; Sukata, T; Wanibuchi, H | 1 |
| Paehler, A; Richoz, J; Soglia, J; Turesky, RJ; Vouros, P | 1 |
| Jägerstad, M; Lundström, K; Olsson, V; Skog, K; Solyakov, A | 1 |
| Alexander, J; Becher, G; Frandsen, H; Hegstad, S; Ingebrigtsen, K; Paulsen, JE; Reistad, R | 1 |
| Asamoto, M; Hirose, M; Inaguma, S; Ogiso, T; Shirai, T; Suzuki, S; Takahashi, S | 1 |
| Ambrosone, CB; Coles, B; Kadlubar, FF; Lang, NP; Luke Ratnasinghe, D; MacLeod, S; Nowell, S; Sinha, R; Stotts, C | 1 |
| Guengerich, FP; Guillouzo, A; Langouët, S; Turesky, RJ | 1 |
| Sinha, R | 1 |
| Hanaoka, T; Kataoka, H; Kobayashi, M; Nishioka, S; Tsugane, S | 1 |
| Arimoto-Kobayashi, S; Fujita, K; Kamataki, T; Negishi, T; Okamoto, K; Takahashi, E | 1 |
| Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Tatematsu, M; Totsuka, Y; Tsuda, H; Tsukamoto, T; Uehara, N; Wakabayashi, K; Wanibuchi, H; Wei, M | 1 |
| Furukawa, F; Hirose, M; Kobayashi, Y; Koide, A; Mori, Y; Nishikawa, A | 1 |
| Gray, JI; Shin, HS; Strasburg, GM | 1 |
| Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Takasuka, N; Tatematsu, M; Tsuda, H; Tsukamoto, T; Wanibuchi, H; Wei, M | 1 |
| Persson, E; Sjöholm, I; Skog, K | 1 |
| Horiguchi, M; Kanke, Y; Kanki, K; Masumura, K; Nishikawa, A; Nohmi, T; Umemura, T | 1 |
| Fukushima, S; Nakae, D; Nishkawa, T; Ogawa, M; Otani, S; Totsuka, Y; Wakabayashi, K; Wanibuchi, H; Yano, Y | 1 |
| Boyce, A; Doehmer, J; Gooderham, NJ | 1 |
| Calvisi, DF; Conner, EA; Factor, VM; Ladu, S; Thorgeirsson, SS | 1 |
| Hümmerich, J; Pfau, W; Zohm, C | 1 |
| Allegro, G; Bertinetti, S; Bianchini, M; Davico, L; Fiorini, L; Hautefeuille, A; Malaveille, C; Sacerdote, C; Vineis, P | 1 |
| Fukushima, S; Hoshi, M; Morimura, K; Okochi, E; Takaoka, K; Ushijima, T; Wanibuchi, H; Wei, M | 1 |
| Freeman, JP; Gooderham, NJ; Holland, RD; Jones, RC; Lake, BG; Miller, DW; Schoenbachler, L; Taylor, J; Turesky, RJ | 1 |
| Kohno, H; Sugie, S; Suzuki, R; Takahashi, M; Tanaka, T; Wakabayashi, K | 1 |
| Borgen, E; Skog, K | 1 |
| Badenhorst, AM; Coetsee, C; Walubo, A | 1 |
| Fukushima, S; Ichihara, T; Morimura, K; Nakae, D; Totsuka, Y; Wanibuchi, H; Wei, M | 1 |
| Hirose, M; Imazawa, T; Ishii, Y; Kanki, K; Kitamura, Y; Kuroiwa, Y; Nishikawa, A; Umemura, T | 1 |
| Abramsson-Zetterberg, L; Durling, LJ | 1 |
| Nyman, M; Persson, E; Sjöholm, I; Skog, K | 1 |
| Arimoto-Kobayashi, S; Fujioka, R; Konuma, T; Nakandakari, N; Okamoto, K; Takata, J | 1 |
| Gehring, T; Gooderham, NJ; Holland, RD; Lake, BG; Taylor, J; Turesky, RJ | 1 |
| Bianchi, F; Careri, M; Corradini, C; Elviri, L; Mangia, A; Zagnoni, I | 1 |
| Hsu, FF; Lakshmi, VM; Zenser, TV | 1 |
| Chubachi, H; Imanishi, H; Inoue, Y; Komasa, Y; Mizoguchi, T; Nakano, M; Takekoshi, H | 1 |
| Arimoto, S; Miyashita, Y; Negishi, T; Okamoto, K; Taira, K; Takahashi, E | 1 |
| Cross, AJ; Hayes, RB; Kulldorff, M; Peters, U; Pinsky, PF; Rothman, N; Sinha, R; Weissfeld, JL | 1 |
| Fukushima, S; Funae, Y; Kang, JS; Kinoshita, A; Kushida, M; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M | 1 |
| Fukushima, S; Hayashi, S; Kinoshita, A; Morimura, K; Nishikawa, T; Nishikawa-Ogawa, M; Wanibuchi, H; Yano, Y | 1 |
| Andriole, GL; Cross, AJ; Hayes, RB; Kirsh, VA; Peters, U; Reding, D; Sinha, R | 1 |
| Fukushima, S; Hori, TA; Ichihara, T; Kang, JS; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M | 1 |
| Asamoto, M; Hokaiwado, N; Kuribayashi, M; Ogawa, K; Shirai, T; Suzuki, S | 1 |
| Hsu, FF; Lakshmi, VM; Schut, HA; Zenser, TV | 1 |
| Bennett, LM; Bennion, BJ; Cosman, M; Felton, JS; Knize, MG; Kulp, KS; Lightstone, FC; Montgomery, JL | 1 |
| Doll, MA; Fretland, AJ; Hein, DW | 1 |
| Doi, K; Fukushima, S; Karim, MR; Kinoshita, A; Morimura, K; Wanibuchi, H; Wei, M | 1 |
| Fukushima, S; Kang, JS; Morimura, K; Totsuka, Y; Wanibuchi, H; Yoshimura, I | 1 |
| Arimoto, S; Negishi, T; Okamoto, K; Takahashi, E | 1 |
| Busquets, R; Galceran, MT; Puignou, L; Toribio, F | 1 |
| Fukushima, S; Kang, JS; Kinoshita, A; Morimura, K; Murai, T; Wanibuchi, H | 1 |
| Bendaly, J; Doll, MA; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; States, JC; Zhao, S | 1 |
| Chen, F; Cheng, KW; Wang, M | 1 |
| Peterson, S; Turesky, RJ; Wang, R; Yu, MC; Yuan, JM | 1 |
| Slob, W | 1 |
| Gibis, M | 1 |
| Chen, F; Cheng, KW; Peng, X; Simon, JE; Wang, M; Wu, Q; Zheng, ZP | 1 |
| Alavanja, MC; Cross, AJ; Hoppin, JA; Koutros, S; Ma, X; Sandler, DP; Sinha, R; Zheng, T | 1 |
| Knasmüller, S; Koller, V; Sontag, G; Stidl, R | 1 |
| Enokizono, J; Kusuhara, H; Ose, A; Schinkel, AH; Sugiyama, Y | 1 |
| Ban, H; Hirata, A; Imai, T; Masegi, T; Nishigaki, R; Sakai, H; Takasu, S; Tatematsu, M; Totsuka, Y; Tsukamoto, T; Wakabayashi, K; Yanai, T | 1 |
| Fukushima, S; Kang, JS; Mori, S; Morimura, K; Murai, T; Totsuka, Y; Wanibuchi, H | 1 |
| Gibis, M; Jautz, U; Morlock, GE | 1 |
| Futakuchi, M; Hirose, M; Kawabe, M; Shirai, T; Tamano, S | 1 |
| Ferreira, IM; Melo, A; Petisca, C; Pinho, O; Viegas, O | 1 |
| Bessette, EE; Goodenough, AK; Kozekov, ID; Langouët, S; Spivack, SD; Turesky, RJ; Yasa, I | 1 |
| Bagnardi, V; Bertazzi, PA; Caporaso, NE; Consonni, D; Cross, AJ; Lam, TK; Landi, MT; Randi, G; Sinha, R; Subar, AF | 1 |
| Libudzisz, Z; Nowak, A | 1 |
| Bendaly, J; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; Smith, NB | 1 |
| Busquets, R; Frandsen, H; Galceran, MT; Jönsson, JA; Puignou, L; Skog, K | 1 |
| Doll, MA; Hein, DW; Howarth, AL; McGregor, WG; Metry, KJ; Neale, JR; Pierce, WM; States, JC | 1 |
| Gooderham, NJ; Gu, D; Kadlubar, FF; Lake, BG; Lemaster, D; McNaughton, L; Turesky, RJ | 1 |
| Cross, AJ; Ferrucci, LM; Graubard, BI; Hollenbeck, AR; Park, Y; Risch, A; Schatzkin, A; Sinha, R; Ward, MH | 1 |
| Aninat, C; Anthérieu, S; Dumont, J; Guguen-Guillouzo, C; Guillouzo, A; Jossé, R; Lambert, C; Le Hegarat, L; Robin, MA | 1 |
| Cho, E; Giovannucci, E; Holmes, MD; Sinha, R; Willett, W; Wu, K | 1 |
| Asamoto, M; Doi, Y; Naiki-Ito, A; Shirai, T; Suzuki, S; Takahashi, S; Takeshita, K | 1 |
| Puangsombat, K; Smith, JS | 1 |
| Haza, AI; Morales, P | 1 |
| Gonzalo-Lumbreras, R; León-González, ME; Pérez-Arribas, LV; Polo-Díez, LM; Rosales-Conrado, N | 1 |
| Anthérieu, S; Dumont, J; Guillouzo, A; Jossé, R; Lambert, C; Laurent, V; Loyer, P; Robin, MA | 1 |
| Inoue, T; Ishii, Y; Kodama, Y; Mitsumori, K; Nishikawa, A; Nohmi, T; Okamura, T; Suzuki, Y; Tasaki, M; Umemura, T | 2 |
| Abnet, CC; Cross, AJ; Freedman, ND; Hollenbeck, AR; Ren, J; Schatzkin, A; Sinha, R; Ward, MH | 1 |
| Caberto, C; Chanock, S; Decker, R; Le Marchand, L; Saltzman, B; Vogt, TM; Wang, H; Wilkens, LR; Yamamoto, JF; Yokochi, L | 1 |
| Gu, D; Kadlubar, FF; Raymundo, MM; Turesky, RJ | 1 |
| Deming, SL; Fair, AM; Fu, Z; Kelley, M; Shrubsole, MJ; Shu, XO; Wujcik, DM; Zheng, W | 1 |
| Arimoto-Kobayashi, S; Hatano, T; Ishida, R; Kamiya, T; Okamoto, G; Yuhara, Y; Zhang, X | 1 |
| Ambalam, P; Dave, JM; Nair, BM; Vyas, BR | 1 |
| Jirapakkul, W; Puangsombat, K; Smith, JS | 1 |
| Bessette, EE; Dunbar, D; Liberman, RG; Skipper, PL; Turesky, RJ | 1 |
| Peng, Z; Shao, B; Wan, K; Wu, G; Yang, H; Yao, Y | 1 |
| Gadgil, P; Houser, TA; Hunt, MC; Puangsombat, K; Smith, JS | 1 |
| Ferreira, IM; Filipič, M; Novak, M; Pezdric, M; Pinho, O; Viegas, O; Zegura, B | 1 |
| Feinstein, Y; Friedman, M; Havens, CM; Ravishankar, S; Rounds, L | 1 |
| Liao, GZ; Wang, GY; Xu, XL; Zhang, YJ; Zhou, GH | 1 |
| Aschebrook-Kilfoy, B; Chiu, BC; Kolar, C; Lawson, TA; Ollberding, NJ; Smith, SM; Weisenburger, DD | 1 |
| Hayashi, H; Hayashi, M; Mitsumori, K; Morita, R; Nakamura, D; Shibutani, M; Suzuki, K; Taniai, E; Wakita, A | 1 |
| Ding, Z; Guo, D; Li, F; Su, M; Wang, M; Yao, J | 1 |
| Fujii-Kuriyama, Y; Goto, M; Iijma, K; Ishizaka, Y; Kano, S; Matsunaga, A; Nakagama, H; Ochiai, M; Okamura, T; Okudaira, N; Tamura, M | 1 |
| Cross, AJ; Harper, G; Hartman, TJ; Laio, J; Lazarus, P; Lesko, SM; Miller, PE; Muscat, JE; Sinha, R; Zhu, J | 1 |
| Gibis, M; Weiss, J | 2 |
| Blasiak, J; Chojnacki, C; Chojnacki, J; Czubatka, A; Klupinska, G; Poplawski, T | 1 |
| Ishii, Y; Jin, M; Kijima, A; Kodama, Y; Kuroda, K; Matsushita, K; Takasu, S; Umemura, T | 1 |
| Filipič, M; Pezdirc, M; Žegura, B | 1 |
| Mei, J; Wang, S; Yu, C; Zhang, Y | 1 |
| Szterk, A | 1 |
| Helmus, DS; Li, L; Thompson, CL; Tucker, TC; Zelenskiy, S | 1 |
| Aalhus, JL; Dugan, ME; Juárez, M; Ruan, ED; Thacker, R; Yang, X | 1 |
| Houser, TA; Hunt, MC; Smith, JS; Vangnai, K | 1 |
| Cooper, KM; Cuskelly, G; Jankhaikhot, N | 1 |
| Gibis, M; Kruwinnus, M; Weiss, J | 1 |
| Chen, J; Gao, Y; He, Z; Qin, F; Tao, G; Zeng, M; Zhang, S; Zheng, Z | 1 |
| Dennis, C; Karim, F; Smith, JS | 1 |
| Artioli, GG; Carpentier, A; Dantas, WS; Dörr, FA; Fernandes, AL; Gualano, B; Murai, IH; Pereira, RT; Pinto, E; Poortmans, JR; Roschel, H; Santinho, MA; Seguro, AC; Solis, MY | 1 |
| Fukushima, S; Gi, M; Kakehashi, A; Matsumoto, M; Wanibuchi, H | 1 |
| Daniel, CR; Karam, JA; Matin, SF; Melkonian, SC; Tannir, NM; Wood, CG; Wu, X; Ye, Y | 1 |
| Anderson, KE; Jensen, EH; Kuhn, EA; Malfatti, MA; Strayer, L; Turteltaub, KW; Vickers, SM | 1 |
| Baffet, G; Bellamri, M; Langouët, S; Le Hegarat, L; Turesky, RJ; Vernhet, L | 1 |
| Guo, J; Krishna, S; Murugan, P; Tejpaul, R; Turesky, RJ; Villalta, PW; Weight, CJ; Xiao, S; Yun, BH | 1 |
| Audebert, M; Chevereau, M; Cravedi, JP; Glatt, H; Zalko, D | 1 |
| Empl, MT; Engels, C; Fekry, MI; Lacroix, C; Schneider, M; Schwab, C; Steinberg, P; Sturla, SJ; Zhang, J | 1 |
| Han, Z; Shao, Z; Wang, S; Zhang, J; Zhang, Y | 1 |
| Agim, ZS; Cannon, JR; Cruz-Hernandez, A; McCabe, GP; Montenegro, PC; Rochet, JC | 1 |
| Castaño, PR; Linseisen, J; Martínez Góngora, V; Matthes, KL; Rohrmann, S | 1 |
| Beer, F; Bunzel, D; Bunzel, M; Franz, CMAP; Huch, M; Kulling, SE; Urbat, F | 1 |
| Guo, R; Huang, H; Liu, R; Oyang, Q; Rong, J; Song, D; Wang, B; Xiao, X; Zheng, P | 1 |
| Breves, G; Empl, MT; Schneider, M; Schröder, B; Stadnicka-Michalak, J; Steinberg, P; Sturla, SJ; Zhang, J | 1 |
| Bao, X; Huang, Y; Lai, K; Miao, J | 1 |
| Angénieux, M; Blinet, P; Chaloin, L; Chevolleau, S; Debrauwer, L; Engel, E; Mercier, F; Meurillon, M | 1 |
| Hidalgo, FJ; Lavado-Tena, CM; Zamora, R | 1 |
| Chen, J; He, Z; Li, Y; Qin, F; Quan, W; Wang, J; Wang, Z; Zeng, M | 1 |
21 review(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines
| Article | Year |
|---|---|
Absorption and disposition of MeIQx in man: lessons for human dosimetry.
Topics: Absorption; Animals; Biotransformation; Carcinogens; Dose-Response Relationship, Drug; Hemoglobins; Humans; Mutagens; Quinoxalines | 1991 |
MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline).
Topics: Animals; Carcinogens; Cooking; Fishes; Food; Food Analysis; Humans; Meat; Neoplasms; Quinoxalines | 1993 |
Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man.
Topics: Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Food Handling; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Meat; Mutagens; Oxidoreductases; Quinoxalines | 1996 |
Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Food Handling; Gene Expression Regulation, Enzymologic; Humans; Hydroxylation; Imidazoles; Liver; Meat Products; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Species Specificity | 1996 |
Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans.
Topics: Amines; Animals; Biotransformation; Carcinogens; Diet; Food Handling; Heterocyclic Compounds; Humans; Imidazoles; Meat; Mice; Mutagens; Neoplasms; Primates; Quinoxalines; Rats; Risk Assessment; Species Specificity; Structure-Activity Relationship | 1996 |
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
Topics: Amines; Animals; Carcinogens, Environmental; DNA Adducts; Environmental Exposure; Food Contamination; Heterocyclic Compounds; Humans; Imidazoles; Mutagens; Mutation; Neoplasms; Quinoxalines | 1996 |
Heterocyclic amines: evaluation of their role in diet associated human cancer.
Topics: Animals; Biological Availability; Carcinogens; Diet; Humans; Imidazoles; Meat; Mutagens; Neoplasms; Quinoxalines | 1996 |
Exposure to and activation of dietary heterocyclic amines in humans.
Topics: Animals; Biological Availability; Biotransformation; Carcinogens; Colorectal Neoplasms; Cooking; Cytochrome P-450 CYP1A2; Diet; DNA Adducts; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Liver; Meat; Mutagenicity Tests; Mutagens; Proteins; Quinolines; Quinoxalines; Rats; Risk Assessment | 1995 |
Synthetic routes to the food carcinogen 2 amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx) and related compounds.
Topics: Animals; Carcinogens; Cooking; Corn Oil; Dietary Fats; Fishes; Free Radicals; Hot Temperature; Humans; Maillard Reaction; Meat; Molecular Structure; Mutagens; Olive Oil; Plant Oils; Quinoxalines; Structure-Activity Relationship | 1995 |
Factors affecting the formation and yield of heterocyclic amines.
Topics: Carcinogens; Cooking; Heterocyclic Compounds; Hot Temperature; Humans; Maillard Reaction; Meat; Mutagens; Quinoxalines | 1995 |
Mutagenic activity and heterocyclic amine content of the human diet.
Topics: Amines; Animals; Cattle; Cooking; Fishes; Food Analysis; Heterocyclic Compounds; Hot Temperature; Humans; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium | 1995 |
Metabolism of heterocyclic aromatic amines and strategies of human biomonitoring.
Topics: Animals; Biotransformation; Blood Proteins; Carcinogens; Cooking; Cytochrome P-450 Enzyme System; Environmental Monitoring; Fishes; Hot Temperature; Humans; Inactivation, Metabolic; Intestinal Absorption; Meat; Mutagens; Primates; Quinolines; Quinoxalines; Rodentia | 1995 |
Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.
Topics: Animals; Carcinogens; DNA Adducts; Humans; Imidazoles; Mass Spectrometry; Mutagens; Neoplasms; Phosphorus Radioisotopes; Quinoxalines; Radioisotope Dilution Technique; Rodentia | 1995 |
Superoxide radical generation from heterocyclic amines.
Topics: Amines; Animals; Carcinogens; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Heterocyclic Compounds; Humans; Kinetics; Microsomes, Liver; Mutagenicity Tests; Mutagens; NADH Dehydrogenase; NADP; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Spin Labels; Superoxides | 1995 |
Activation and effects of the food-derived heterocyclic amines in extrahepatic tissues.
Topics: Amines; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cell Line; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA Damage; Food; Heterocyclic Compounds; Hot Temperature; Humans; Hypoxanthine Phosphoribosyltransferase; Imidazoles; Lung; Meat; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Quinoxalines; Rats | 1995 |
Enzymatic studies of the activation of heterocyclic food mutagens in man.
Topics: Animals; Biotransformation; Callithrix; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Macaca fascicularis; Meat; Microsomes, Liver; Mutagens; Quinoxalines; Rabbits; Substrate Specificity | 1995 |
Systemic exposure to dietary heterocyclic amines in man.
Topics: Animals; Biotransformation; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Diet; Environmental Exposure; Enzyme Inhibitors; Hot Temperature; Humans; Imidazoles; Meat; Metabolic Clearance Rate; Mutagens; Quinoxalines; Theophylline | 1995 |
Biomarkers of exposure to heterocyclic amines: approaches to improve the exposure assessment.
Topics: Animals; Biomarkers; Carcinogens; Dose-Response Relationship, Drug; Environmental Exposure; Environmental Monitoring; Hair; Heterocyclic Compounds; Humans; Imidazoles; Mice; Quinoxalines | 2002 |
An epidemiologic approach to studying heterocyclic amines.
Topics: Amines; Animals; Carcinogens; Cooking; Diet; Dietary Proteins; Epidemiologic Studies; Heterocyclic Compounds; Humans; Imidazoles; Meat Products; Neoplasms; Quinoxalines; Risk Factors; Surveys and Questionnaires | 2002 |
Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Guanosine; Humans; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 2016 |
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
Topics: Adenoma; Adult; Aged; Amines; Benzo(a)pyrene; Colorectal Neoplasms; Diet; Female; Heterocyclic Compounds; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Odds Ratio; Quinoxalines; Red Meat | 2019 |
5 trial(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines
| Article | Year |
|---|---|
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.
Topics: Adult; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Imidazoles; Male; Oxidoreductases; Phenacetin; Quinoxalines; Theophylline | 1994 |
Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans.
Topics: Administration, Oral; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Female; Food Contamination; Humans; Male; Microsomes, Liver; Middle Aged; Mutagens; Quinoxalines; Reference Standards; Smoking | 1998 |
Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity.
Topics: Adult; Animals; Antimutagenic Agents; Chlorodiphenyl (54% Chlorine); Diet; DNA Adducts; Flavonoids; Humans; Male; Microsomes, Liver; Mutagenicity Tests; Phenols; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Smoking; Spectrophotometry | 2004 |
A prospective study of meat and meat mutagens and prostate cancer risk.
Topics: Aged; Benzo(a)pyrene; Cooking; Diet; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Prospective Studies; Prostatic Neoplasms; Quinoxalines; Risk Factors; Surveys and Questionnaires | 2005 |
Can creatine supplementation form carcinogenic heterocyclic amines in humans?
Topics: Adult; Amines; Carcinogens; Creatine; Cross-Over Studies; Diet; Female; Furans; Humans; Imidazoles; Male; Quinoxalines; Single-Blind Method | 2015 |
327 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines
| Article | Year |
|---|---|
Effect of dietary fiber on the disposition and excretion of a food carcinogen (2-14C-labeled MeIQx) in rats.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Dietary Fiber; DNA; Gastrointestinal Transit; In Vitro Techniques; Male; Mutagens; Pectins; Poaceae; Quinoxalines; Rats; Rats, Inbred Strains; Solubility | 1992 |
Reversible binding of the cooked food mutagen MeIQx to lignin-enriched preparations from wheat bran.
Topics: Dietary Fiber; Lignin; Microscopy, Electron, Scanning; Mutagenicity Tests; Mutagens; Quinoxalines; Triticum | 1992 |
Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro.
Topics: Amines; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; DNA; Electron Spin Resonance Spectroscopy; Heterocyclic Compounds; Hydroxylation; Kinetics; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; NADP; NADPH-Ferrihemoprotein Reductase; Pentetic Acid; Quinolines; Quinoxalines; Reactive Oxygen Species; Superoxides | 1992 |
Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed.
Topics: Dose-Response Relationship, Drug; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Reproducibility of Results; Salmonella typhimurium | 1992 |
Effect of hepatic cytochrome P-450 inducing agents on mutagen activity in the host-mediated assay.
Topics: Aflatoxins; Analysis of Variance; Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Mice; Mice, Inbred BALB C; Mutagenesis; Mutagenicity Tests; Mutagens; Phenobarbital; Quinoxalines; Salmonella typhimurium | 1992 |
Inhibition of the metabolism of mutagens occurring in food by arachidonic acid.
Topics: Aflatoxin B1; Animals; Antimutagenic Agents; Arachidonic Acid; Biotransformation; DNA Repair; Food; Imidazoles; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 1992 |
Electron impact and fast atom bombardment mass spectrometric analysis of the food-borne carcinogens 2-amino-3-methylimidazo [4,5-f] quinoline, 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline and their metabolites.
Topics: Carcinogens; Food Analysis; Glucuronates; Quinolines; Quinoxalines; Spectrometry, Mass, Fast Atom Bombardment; Sulfates | 1992 |
Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.
Topics: Adult; Animals; Carcinogens; Cattle; Cooking; Gas Chromatography-Mass Spectrometry; Genetic Variation; Humans; Imidazoles; Individuality; Male; Meat; Mutagens; Quinoxalines | 1992 |
N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Humans; Hydroxylation; Mass Spectrometry; Microsomes, Liver; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Theophylline | 1992 |
Tissue distribution of the food mutagen MeIQx in control and BNF-treated mice.
Topics: Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; Drug Interactions; Female; Injections, Intravenous; Mice; Mutagens; Quinoxalines; Tissue Distribution | 1992 |
Metabolic activation and genotoxicity of heterocyclic arylamines.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; DNA; Heterocyclic Compounds; Imidazoles; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Polychlorinated Dibenzodioxins; Quinolines; Quinoxalines; Salmonella | 1992 |
Chemical analysis, prevention, and low-level dosimetry of heterocyclic amines from cooked food.
Topics: DNA; Food Analysis; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Meat; Mutagenicity Tests; Quinolines; Quinoxalines | 1992 |
Direct O-acetylation of N-hydroxy arylamines by acetylsalicylic acid to form carcinogen-DNA adducts.
Topics: Acetylation; Aminobiphenyl Compounds; Aspirin; Carcinogens; DNA; Fluorenes; Imidazoles; Quinolines; Quinoxalines | 1992 |
Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; DNA; Male; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in two strains of male rats.
Topics: Animals; Autoradiography; Kidney; Liver; Male; Mutagens; Quinoxalines; Rats; Skin; Species Specificity; Tissue Distribution | 1992 |
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; DNA; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 1992 |
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
Topics: Aminobiphenyl Compounds; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Imidazoles; Liver Neoplasms, Experimental; Male; Mice; Mutagens; Quinolines; Quinoxalines | 1992 |
Distribution and elimination of [2-14C]amino-3,8-dimethylimidazo [4, 5-f] quinoxaline in mice. Analysis by whole animal autoradiography.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Male; Mice; Mice, Inbred Strains; Quinoxalines; Tissue Distribution | 1991 |
Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats.
Topics: Animals; Binding, Competitive; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation; Imidazoles; Intestines; Kidney; Liver; Lung; Male; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA | 1990 |
An experimental approach to identifying the genotoxic risk from cooked meat mutagens.
Topics: Administration, Oral; Animals; Cattle; Cell Line; Chromosome Aberrations; Cooking; Cricetinae; Cricetulus; DNA; Female; Food Contamination; Humans; Male; Meat; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Risk Factors; Tissue Distribution | 1991 |
An experimental approach to identifying the genotoxic risk by cooked meat mutagens.
Topics: Animals; Bone Marrow; Cell Line; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymphocytes; Male; Meat Products; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Protein Binding; Quinolines; Quinoxalines; Salmonella typhimurium; Tissue Distribution | 1991 |
Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbolines; Diet; Female; Humans; Imidazoles; Male; Middle Aged; Parenteral Nutrition, Total; Quinoxalines | 1991 |
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.
Topics: Acetylation; Amines; Animals; Biotransformation; Carcinogens; Colon; Cytochrome P-450 Enzyme System; Cytosol; Heterocyclic Compounds; Humans; Imidazoles; Liver; Microsomes, Liver; Mutagens; Oxidation-Reduction; Quinolines; Quinoxalines; Rats | 1991 |
The effect of dose and cytochrome P450 induction on the metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) in the rat.
Topics: 1-Naphthylamine; Animals; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Feces; Glucuronates; Glucuronosyltransferase; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Mutagens; Nitrophenols; Oxidation-Reduction; Quinoxalines; Rats; Rats, Inbred Strains; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet | 1991 |
The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines.
Topics: Administration, Oral; Aging; Amines; Animals; Carbolines; Diet; DNA; DNA Damage; Heart; Imidazoles; Kinetics; Liver; Male; Myocardium; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
DNA dosimetry following carcinogen exposure using accelerator mass spectrometry and 32P-postlabeling.
Topics: Animals; Binding Sites; Carcinogens; DNA; DNA Damage; Humans; Imidazoles; Mass Spectrometry; Mice; Phosphorus Radioisotopes; Quinoxalines | 1991 |
Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines.
Topics: Animals; Carcinoma, Squamous Cell; Codon; Ear Neoplasms; Ear, External; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Sebaceous Gland Neoplasms | 1991 |
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
Topics: Animals; Body Weight; Carbolines; Carcinogens; Drug Synergism; Enzyme Induction; Glutathione Transferase; Imidazoles; Immunohistochemistry; Liver; Liver Neoplasms; Male; Organ Size; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry.
Topics: Animals; Carbon Radioisotopes; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Hydrolysis; In Vitro Techniques; Mice; Microsomes; Mutagens; Quinolines; Quinoxalines | 1991 |
DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Drug Resistance; Glutathione Transferase; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344; Time Factors | 1990 |
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Immunologic; Imidazoles; Liver Neoplasms, Experimental; Macaca fascicularis; Mutagens; Quinolines; Quinoxalines | 1990 |
Human neutrophils can activate the food-derived carcinogen MeIQx.
Topics: Biotransformation; Carcinogens; DNA; Food Contamination; Humans; In Vitro Techniques; Mutagens; Neutrophils; Quinoxalines; Superoxides | 1990 |
Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx.
Topics: Animals; Biotransformation; Cattle; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Guinea Pigs; Hot Temperature; Humans; Intestinal Absorption; Isoenzymes; Male; Meat; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinoxalines; Rabbits; Salmonella typhimurium; Species Specificity; Theophylline | 1990 |
Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Mapping; Dimethylhydrazines; Dimethylnitrosamine; Epithelium; Female; Intestine, Small; Male; Mice; Mice, Inbred Strains; Mutagenesis; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium | 1990 |
Inflammatory cells from the rat pleural cavity can activate the food-derived carcinogen MeIQx.
Topics: Animals; Biotransformation; Carcinogens; Food Contamination; In Vitro Techniques; Inflammation; Mutagens; Phagocytes; Pleura; Quinoxalines; Rats | 1990 |
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Enzyme Induction; Galactosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Phenobarbital; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1990 |
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
Topics: 2-Acetylaminofluorene; Adolescent; Adult; Aged; Benzo(a)pyrene; Cell Line; Child; Cytochrome P-450 Enzyme System; Food Contamination; Gene Expression; Humans; Hydroxylation; Imidazoles; Microsomes, Liver; Middle Aged; Quinolines; Quinoxalines | 1990 |
Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Dioxins; DNA; Dose-Response Relationship, Drug; Kinetics; Liver; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Phosphorus Radioisotopes; Polychlorinated Dibenzodioxins; Quinoxalines | 1990 |
Effects of monosaccharides and disaccharides on the formation of food mutagens in model systems.
Topics: Chromatography, High Pressure Liquid; Creatine; Creatinine; Disaccharides; Ethylene Glycols; Food; Glycine; Hot Temperature; Maillard Reaction; Monosaccharides; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella; Temperature | 1990 |
Mechanism of the in vitro antimutagenic action of retinol.
Topics: Animals; Biotransformation; Computer Simulation; In Vitro Techniques; Male; Models, Biological; Mutagenicity Tests; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Submitochondrial Particles; Vitamin A | 1990 |
Role of metabolism on the DNA binding of MeIQx in mice and bacteria.
Topics: Animals; DNA; DNA, Bacterial; Liver; Male; Mice; Mice, Inbred C57BL; Mutagens; Phosphorus Radioisotopes; Quinoxalines; Radioisotope Dilution Technique; Salmonella typhimurium | 1990 |
Nucleic acid binding and mutagenicity of active metabolites of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; DNA Damage; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Mutation; Nucleic Acid Conformation; Quinoxalines; RNA; Structure-Activity Relationship; Ultraviolet Rays | 1989 |
The food-mutagens 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) initiate enzyme-altered hepatic foci in the resistant hepatocyte model.
Topics: Animals; Diethylnitrosamine; Drug Resistance; gamma-Glutamyltransferase; Imidazoles; Liver; Male; Meat; Mutagens; Quinoxalines; Rats; Rats, Inbred Strains | 1989 |
Purification of the food-borne carcinogens 2-amino-3-methylimidazo [4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in heated meat products by immunoaffinity chromatography.
Topics: Animals; Antibodies, Monoclonal; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Hot Temperature; Immunologic Techniques; Meat; Mutagens; Quinolines; Quinoxalines; Radioimmunoassay | 1989 |
Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats.
Topics: Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Male; Mutagenicity Tests; Mutagens; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sex Factors; Tissue Distribution | 1989 |
Covalent binding of [2-14C]2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) to mouse DNA in vivo.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; DNA; Female; Kinetics; Mice; Mice, Inbred BALB C; Mutagens; Quinoxalines; Radioisotope Dilution Technique; Tissue Distribution | 1989 |
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Male; Meat; Mutagens; Quinoxalines | 1989 |
Significant increase of IQ-type heterocyclic amines, dietary carcinogens in the plasma of patients with uremia just before induction of hemodialysis treatment.
Topics: Adult; Carcinogens; Chromatography, High Pressure Liquid; Diet; Female; Humans; Male; Middle Aged; Mutagens; Quinolines; Quinoxalines; Renal Dialysis; Uremia | 1989 |
Metabolism of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in isolated rat liver cells.
Topics: Animals; Aroclors; Biotransformation; Carcinogens; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Food; Glucuronates; Glutathione; Liver; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred Strains | 1989 |
Effect of heterocyclic amines and beef extract on chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes.
Topics: Animals; Cattle; Cells, Cultured; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Humans; Lymphocytes; Meat; Mutagens; Quinolines; Quinoxalines; Sister Chromatid Exchange | 1989 |
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Topics: Animals; Biotransformation; Carbolines; Carcinogens; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Insulin; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Mutagenicity Tests; Mutagens; Niacinamide; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains | 1988 |
In vitro reaction of hydroxyamino derivatives of MeIQx, Glu-P-1 and Trp-P-1 with DNA: 32P-postlabelling analysis of DNA adducts formed in vivo by the parent amines and in vitro by their hydroxyamino derivatives.
Topics: Animals; Binding Sites; Carbolines; Carcinogens; DNA; Hydroxylamines; Imidazoles; In Vitro Techniques; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344 | 1988 |
The presence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in smoked dry bonito (katsuobushi).
Topics: Chromatography, High Pressure Liquid; Fish Products; Food Handling; Mutagens; Quinoxalines; Spectrophotometry, Ultraviolet | 1986 |
Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Quinoxalines; Rats; Rats, Inbred Strains; Subcellular Fractions | 1988 |
Analysis of mutagenic heterocyclic amines in cooked beef products by high-performance liquid chromatography in combination with mass spectrometry.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Hot Temperature; Mass Spectrometry; Meat; Mutagenicity Tests; Quinolines; Quinoxalines | 1988 |
Distribution of radiolabelled [2-14C]IQ and MeIQx in the mouse.
Topics: Administration, Oral; Animals; Carbon Radioisotopes; Carcinogens; Chromatography, Thin Layer; Female; Gastrointestinal Contents; Intestinal Absorption; Mice; Mice, Inbred BALB C; Quinolines; Quinoxalines; Tissue Distribution | 1988 |
A model system for studying covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein.
Topics: Animals; Biotransformation; Carcinogens; DNA; Food Analysis; In Vitro Techniques; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats | 1988 |
An assay for 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline in fried beef using capillary column gas chromatography electron capture negative ion chemical ionization mass spectrometry.
Topics: Animals; Carbon Isotopes; Cattle; Cooking; Gas Chromatography-Mass Spectrometry; Meat; Mutagens; Nitrogen Isotopes; Quinoxalines | 1988 |
Formation of mutagens, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), in heated fish meats.
Topics: Animals; Cooking; Creatine; Desiccation; Fishes; Hot Temperature; Mutagenicity Tests; Quinoxalines; Rats; Salmonella typhimurium; Species Specificity | 1987 |
The hepatic conversion of some heterocyclic amines to bacterial mutagens is modified by dietary fat and cholesterol.
Topics: Animals; Biotransformation; Cattle; Cholesterol, Dietary; Dietary Fats; Hot Temperature; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1987 |
Effect of tryptamine on the mutagenic activity of 2-amino-3-methylimidazo(4,5-f) quinoline (IQ) and related azaarenes in the Ames test.
Topics: Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytosol; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity; Tryptamines | 1987 |
Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Clitoris; Female; Food; Genital Neoplasms, Female; Hot Temperature; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms | 1988 |
Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cooking; Gas Chromatography-Mass Spectrometry; Meat; Mutagens; Quinoxalines | 1988 |
Metabolism of the food-borne mutagen/carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat: assessment of biliary metabolites for genotoxicity.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Male; Mutagenicity Tests; Quinoxalines; Rats; Rats, Inbred Strains | 1988 |
Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Carcinogens; Feces; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Male; Quinoxalines; Rats; Rats, Inbred Strains | 1988 |
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.
Topics: China; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cooking; Diet; Food Analysis; Heterocyclic Compounds; Imidazoles; Mutagenicity Tests; Mutagens; Mutation; Neoplasms; Quinolines; Quinoxalines | 1988 |
MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline).
Topics: Animals; Chemical Phenomena; Chemistry; Female; Male; Meat Products; Mice; Mutagenicity Tests; Quinoxalines; Rats | 1986 |
Mutagenic metabolites in urine and feces of rats fed with 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, a carcinogenic mutagen present in cooked meat.
Topics: Animals; Biotransformation; Carcinogens; Feces; Hot Temperature; Magnetic Resonance Spectroscopy; Male; Meat; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1987 |
Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods.
Topics: Animals; Cooking; Female; Food Analysis; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma; Male; Mice; Mutagens; Neoplasms, Experimental; Quinoxalines | 1987 |
Metabolism of the mutagen MeIQx in vivo: metabolite screening by liquid chromatography-thermospray mass spectrometry.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Mass Spectrometry; Mice; Quinoxalines | 1987 |
Detection of IQ-type heterocyclic amines in dialysis fluid of uremic patients treated by peritoneal dialysis.
Topics: Adult; Female; Humans; Male; Middle Aged; Mutagens; Peritoneal Dialysis, Continuous Ambulatory; Quinolines; Quinoxalines; Uremia | 1987 |
Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens.
Topics: Animals; Biotransformation; Carbolines; Cricetinae; DNA; DNA Repair; Liver; Male; Mesocricetus; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Presence of 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) in dialysate from patients with uremia.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Quinoxalines; Renal Dialysis; Spectrum Analysis; Uremia | 1986 |
Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Carcinoma, Squamous Cell; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms | 1985 |
Mammalian cell DNA damage by some heterocyclic food mutagens is correlated with their potency in the Ames test.
Topics: 2-Acetylaminofluorene; Animals; DNA; Food Analysis; Food Handling; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium | 1985 |
An improved synthesis of 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine ("MeIQx") and its 2-14C-labelled analogue.
Topics: Chemical Phenomena; Chemistry; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mutagens; Quinoxalines | 1985 |
Quantification of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC).
Topics: Animals; Cattle; Chromatography, Liquid; Meat; Mutagens; Quinolines; Quinoxalines | 1985 |
Characterization of mutagenic fractions in beef extract and in cooked ground beef. Use of blue-cotton for efficient extraction.
Topics: Adsorption; Animals; Cattle; Chromatography; Chromatography, High Pressure Liquid; Meat; Mutagens; Quinolines; Quinoxalines | 1983 |
Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose.
Topics: Chemical Phenomena; Chemistry; Creatinine; Glucose; Glycine; Hot Temperature; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Mutagens; Quinoxalines | 1984 |
Qualitative and quantitative characterization of mutagens in commercial beef extract.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Food Analysis; Food Handling; Meat; Mutagens; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet | 1983 |
DNA-binding of IQ, Me-IQ and Me-IQx, strong mutagens found in broiled foods.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cooking; DNA; Hot Temperature; Mutagens; Quinolines; Quinoxalines; Spectrophotometry; Thymus Gland | 1982 |
Heterocyclic aromatic amine content of selected beef flavors.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Creatine; Creatinine; Dose-Response Relationship, Drug; Flavoring Agents; Imidazoles; Linear Models; Meat Products; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium | 1994 |
Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.
Topics: Adult; Arylamine N-Acetyltransferase; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mutagens; Oxidoreductases; Quinoxalines | 1995 |
Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythrocebus patas; Female; Humans; Hydroxylation; Immunoblotting; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Polychlorinated Dibenzodioxins; Quinolines; Quinoxalines; Rats; Rifampin; Species Specificity; Substrate Specificity | 1995 |
Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Adenoma; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; DNA Adducts; Glutathione Transferase; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344; Time Factors | 1995 |
Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.
Topics: Amines; Animals; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Carcinogens; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression; Gene Transfer Techniques; Humans; Quinolines; Quinoxalines | 1995 |
Heterocyclic amine content in fast-food meat products.
Topics: Amines; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Food Contamination; Heterocyclic Compounds; Imidazoles; Maryland; Meat Products; Mutagenicity Tests; Mutagens; Quinoxalines; Reference Standards | 1995 |
The consequences of fruit and vegetable fibre fermentation on their binding capacity for MeIQx and the effects of soluble fibre sources on the binding affinity of wheat bran preparations.
Topics: Carcinogens; Dietary Fiber; Fermentation; Fruit; Mucins; Quinoxalines; Triticum; Vegetables | 1995 |
Effects of Maillard reaction products on mutagen formation in boiled pork juice.
Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Meat; Mutagens; Picolines; Pyrazines; Quinolines; Quinoxalines; Swine; Thiophenes | 1995 |
Suppressing effects of S phase post-treatment with carbolines on sister-chromatid exchanges induced by mitomycin C in Chinese hamster cells.
Topics: Animals; Antimutagenic Agents; Carbolines; CHO Cells; Cricetinae; Mitomycin; Mutagens; Quinolines; Quinoxalines; S Phase; Sister Chromatid Exchange | 1993 |
The effects of a soluble-fibre polysaccharide on the adsorption of carcinogens to insoluble dietary fibres.
Topics: 1-Octanol; Adsorption; Analysis of Variance; Benzo(a)pyrene; Carbolines; Carcinogens; Cellulose; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dietary Fiber; Dose-Response Relationship, Drug; Gum Arabic; Mutagenicity Tests; Mutagens; Octanols; Pyrenes; Quinoxalines; Solubility; Structure-Activity Relationship; Triticum; Water | 1995 |
Formation of 2-amino-3-methylimidazo[4,5-f]quinoline- and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed mammalian phenol sulfotransferases.
Topics: Animals; Arylsulfotransferase; Cell Line; Cytosol; DNA, Complementary; Female; Gene Expression; Kinetics; Liver; Male; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfonic Acids | 1995 |
[Improved microbiological assay of heterocyclic aromatic amines in cooked food].
Topics: Amines; Animals; Carcinogens; Cooking; Food Analysis; Heterocyclic Compounds; Humans; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium; Sensitivity and Specificity | 1995 |
Metabolism of the food-derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in nonhuman primates.
Topics: Animals; Biotransformation; Female; Macaca fascicularis; Magnetic Resonance Spectroscopy; Quinoxalines | 1995 |
The effect of fibre source and fermentation on the apparent hydrophobic binding properties of wheat bran preparations for the mutagen 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Topics: Animals; Dietary Fiber; Fermentation; Kinetics; Mutagens; Quinoxalines; Triticum | 1995 |
Dose-response studies of MeIQx in rat liver and liver DNA at low doses.
Topics: Animals; Biological Availability; Carbon Radioisotopes; Carcinogens; DNA; DNA Adducts; Dose-Response Relationship, Drug; Liver; Male; Mass Spectrometry; Mutagens; Nucleotides; Quinoxalines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tissue Distribution | 1995 |
Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.
Topics: Carcinogens; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hot Temperature; Humans; Imidazoles; Male; Meat; Oxidoreductases; Polycyclic Compounds; Quinoxalines | 1994 |
Effect of microwave pretreatment on heterocyclic aromatic amine mutagens/carcinogens in fried beef patties.
Topics: Amines; Amino Acids; Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Cooking; Creatine; Creatinine; Food Irradiation; Glucose; Heterocyclic Compounds; Imidazoles; Meat; Microwaves; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella | 1994 |
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Acetyltransferases; Aflatoxin B1; Animals; Cell Line; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; RNA, Messenger | 1994 |
Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties.
Topics: Animals; Cattle; Cooking; Hot Temperature; Imidazoles; Meat; Mutagens; Quinolines; Quinoxalines; Time Factors | 1994 |
Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions.
Topics: Antioxidants; Carcinogens; Cooking; Fish Products; Imidazoles; Meat Products; Mutagens; Quinolines; Quinoxalines | 1994 |
Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.
Topics: Animals; Dogs; Glucuronates; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1994 |
Prevention of heterocyclic amine formation by tea and tea polyphenols.
Topics: Antineoplastic Agents; Biflavonoids; Carcinogens; Catechin; Gallic Acid; Imidazoles; Quinoxalines; Tea | 1994 |
Dose-response study of MeIQx carcinogenicity in F344 male rats.
Topics: Animals; Carcinogens; Female; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms | 1994 |
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
Topics: Animals; Colon; Cytosol; DNA; Glutathione; Glutathione Transferase; Humans; Imidazoles; Liver; Quinolines; Quinoxalines; Rats | 1994 |
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Heterozygote; Hydroxylation; Imidazoles; Immunohistochemistry; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mutagenesis; Mutagens; Oxidoreductases; Quinoxalines | 1994 |
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.
Topics: Animals; Biotransformation; Callithrix; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Immunoblotting; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Species Specificity | 1994 |
In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Antimutagenic Agents; Beverages; Biotransformation; Fruit; In Vitro Techniques; Male; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vegetables | 1994 |
Studies on the mutagenic activation of heterocyclic amines by cynomolgus monkey, rat and human microsomes show that cynomolgus monkeys have a low capacity to N-oxidize the quinoxaline-type heterocyclic amines.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Indoles; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1993 |
Incorporation of carbon atoms from glucose into the food mutagens MeIQx and 4,8-DiMeIQx using 14C-labelled glucose in a model system.
Topics: Carbon; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Glucose; Hot Temperature; Maillard Reaction; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella; Threonine | 1993 |
Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.
Topics: Acetyltransferases; Amino Acyl-tRNA Synthetases; Animals; Colon; Cytosol; DNA; Imidazoles; Kidney; Liver; Macaca fascicularis; Male; Myocardium; Phosphoric Monoester Hydrolases; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Species Specificity; Sulfotransferases | 1993 |
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Quinolines; Quinoxalines; Rats; Rats, Wistar | 1993 |
Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx.
Topics: Animals; Chromatography, Thin Layer; DNA; Guanosine Diphosphate; Isotope Labeling; Liver; Male; Phosphorus Radioisotopes; Quinoxalines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Single-Strand Specific DNA and RNA Endonucleases | 1993 |
Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn.
Topics: Animal Feed; Animals; Animals, Newborn; Carcinogens; DNA; Female; Imidazoles; Kidney; Lactation; Liver; Mammary Glands, Animal; Milk; Mutagenicity Tests; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Salmonella typhimurium | 1993 |
Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings.
Topics: Animals; Carbolines; Carcinogens; Cattle; Cooking; Fishes; Hot Temperature; Imidazoles; Meat; Quinoxalines; Swine; Time Factors | 1993 |
Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res., 52: 6216-6223, 1992.
Topics: Animals; Carcinogens, Environmental; Cattle; Cooking; Humans; Imidazoles; Meat; Quinoxalines | 1993 |
Activation of the food derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat pleural cavity inflammatory cells.
Topics: Animals; Biotransformation; Carcinogens; Enzyme Inhibitors; Food Analysis; Free Radical Scavengers; Male; Mutagenicity Tests; Phagocytes; Pleura; Quinoxalines; Rats; Rats, Wistar; Superoxides | 1993 |
Metabolism of the food-borne carcinogens 2-amino-3-methylimidazo-[4,5-f]quinoline and 2-amino-3,8- dimethylimidazo[4,5-f]-quinoxaline in the rat as a model for human biomonitoring.
Topics: Animals; Biotransformation; Blood Proteins; Carcinogens; Environmental Monitoring; Food Contamination; Humans; In Vitro Techniques; Liver; Male; Protein Binding; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley | 1993 |
Exposure to heterocyclic amines.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Animals; Carcinogens; Female; Food Contamination; Heterocyclic Compounds; Humans; Imidazoles; Male; Middle Aged; Mutagens; Quinoxalines | 1993 |
Immunoaffinity purification of dietary heterocyclic amine carcinogens.
Topics: Animals; Carcinogens; Cattle; Chromatography, Affinity; Diet; Food Contamination; Hot Temperature; Humans; Imidazoles; Meat; Quinoxalines; Rats | 1993 |
32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
Topics: Animals; Autoradiography; Chromatography, High Pressure Liquid; DNA; DNA Damage; Haplorhini; Imidazoles; Liver; Mutagens; Phosphorus Radioisotopes; Polynucleotides; Quinolines; Quinoxalines | 1993 |
Influence of dietary fat on DNA binding by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the mouse liver.
Topics: Administration, Oral; Animals; Dietary Fats; DNA; Female; Liver; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Quinoxalines | 1993 |
Quantification of the carcinogens 2-amino-3,8-dimethyl- and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in food using a combined assay based on gas chromatography-negative ion mass spectrometry.
Topics: Animals; Carcinogens; Cattle; Chickens; Gas Chromatography-Mass Spectrometry; Imidazoles; Isotope Labeling; Meat; Meat Products; Mutagens; Quinoxalines; Reference Standards; Swine | 1993 |
Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Activation; Food; Hot Temperature; Imidazoles; Lung; Male; Mice; Microsomes; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinoxalines; Rats; Rats, Wistar | 1993 |
Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Diet; Drug Administration Schedule; Glutathione Transferase; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344 | 1993 |
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.
Topics: Animals; Biotransformation; DNA Damage; Female; Humans; Imidazoles; Macaca fascicularis; Male; Microsomes, Liver; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Species Specificity; Tissue Distribution | 1993 |
Effects of edible oils and fatty acids on the formation of mutagenic heterocyclic amines in a model system.
Topics: Amines; Creatinine; Dietary Fats, Unsaturated; Fatty Acids; Glucose; Glycine; Heterocyclic Compounds; Mutagens; Oxidation-Reduction; Quinoxalines | 1993 |
Molecular dosimetry of the food-borne carcinogen MeIQx using adducts of serum albumin.
Topics: Adult; Animals; Blood Proteins; Carbon Radioisotopes; Carcinogens; Chromatography, Affinity; Food Contamination; Hemoglobins; Humans; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Protein Binding; Quinoxalines; Serum Albumin; Ultrafiltration | 1993 |
Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.
Topics: Alkalies; Animals; Autoradiography; Blotting, Southern; CHO Cells; Cooking; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; DNA, Bacterial; Electrophoresis; Endodeoxyribonucleases; Escherichia coli; Food Contamination; Intercalating Agents; Mutagens; Phosphorus Radioisotopes; Plasmids; Quinolines; Quinoxalines; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1993 |
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug Synergism; Enzyme Induction; Glutathione Transferase; Liver; Methylcholanthrene; Phenobarbital; Quinoxalines; Rats; Xenobiotics | 1993 |
Effects of enzyme induction on the distribution of the food carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-ss]-quinoxaline (MeIQx) in Ah-receptor- responsive- and Ah-receptor-non-responsive mice.
Topics: Animals; Carcinogens; Enzyme Induction; Hydroxylation; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Quinoxalines; Safrole; Species Specificity; Spleen; Tissue Distribution | 1995 |
Dietary caffeine reduces the genotoxicity of MeIQx in the host-mediated assay in mice.
Topics: Animals; Caffeine; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Drug Interactions; Female; Liver; Mice; Mice, Inbred BALB C; Quinoxalines; Salmonella typhimurium | 1995 |
Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinogens; Copper; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred Strains | 1996 |
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
Topics: Animals; Body Weight; Carcinogens; Diet; Glutathione Transferase; Guanine; Liver; Liver Neoplasms; Male; Organ Size; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 1996 |
Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rabbit.
Topics: Age Factors; Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Quinoxalines; Rabbits | 1996 |
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.
Topics: Aged; Aged, 80 and over; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA Adducts; Female; Humans; Imidazoles; Male; Middle Aged; Quinoxalines | 1996 |
Inhibition of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-mediated DNA-adduct formation by chlorophyllin in Drosophila.
Topics: Animals; Antimutagenic Agents; Autoradiography; Chlorophyllides; DNA; DNA Adducts; DNA Damage; Drosophila; Female; Male; Mutagens; Phosphorus Radioisotopes; Quinoxalines | 1996 |
Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Base Sequence; Binding Sites; Carcinogens; DNA Adducts; DNA-Directed DNA Polymerase; DNA, Bacterial; Escherichia coli; Lac Operon; Molecular Sequence Data; Molecular Structure; Mutagens; Mutation; Quinoxalines; R Factors | 1996 |
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
Topics: Animals; Carbolines; DNA Adducts; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Lac Operon; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Microsomes; Mutagenesis; Mutagens; Quinolines; Quinoxalines | 1996 |
Metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in nonhuman primates.
Topics: Animals; Biotransformation; Carcinogens; Cooking; Food; Hot Temperature; Imidazoles; Macaca fascicularis; Mutagens; Quinolines; Quinoxalines | 1995 |
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.
Topics: Amines; Animals; Carcinoma, Hepatocellular; Cattle; Cooking; DNA Adducts; Fishes; Heterocyclic Compounds; Hot Temperature; Humans; Liver Neoplasms; Macaca fascicularis; Meat; Mutagens; Poultry; Primates; Quinolines; Quinoxalines; Tissue Distribution | 1995 |
MeIQx (2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline): metabolism in humans and urinary metabolites in human populations.
Topics: Adult; Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Diet; Dietary Fats; Ethnicity; Humans; Male; Meat; Mutagens; Primates; Quinoxalines; Rats | 1995 |
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; Humans; Imidazoles; Inflammation; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macaca fascicularis; Meat; Myocardium; Necrosis; Quinolines; Quinoxalines | 1995 |
Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates.
Topics: Animals; Carcinogens; Equipment Design; Imidazoles; Laparoscopes; Laparoscopy; Liver Neoplasms, Experimental; Macaca mulatta; Palpation; Quinolines; Quinoxalines; Reproducibility of Results; Time Factors | 1995 |
Genetic alterations in HCA-induced tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazoles; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Point Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms | 1995 |
Cytogenetic results from a chronic feeding study of MeIQx in mice.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Chromosome Aberrations; Culture Media; Female; Femur; Fluorescein-5-isothiocyanate; Food Handling; In Situ Hybridization, Fluorescence; Lymphocytes; Mice; Mice, Inbred C57BL; Micronucleus Tests; Mutagens; Quinoxalines; Sister Chromatid Exchange | 1996 |
Effect of commercial marinades on the mutagenic activity, sensory quality and amount of heterocyclic amines in chicken grilled under different conditions.
Topics: Animals; Carcinogens; Chickens; Food Additives; Food Contamination; Food Handling; Food Preservation; Gas Chromatography-Mass Spectrometry; Hot Temperature; Humans; Imidazoles; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Taste | 1996 |
An overview of cancer prevention.
Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure; Humans; Imidazoles; Mutagens; Neoplasms; Neoplasms, Unknown Primary; Precancerous Conditions; Primary Prevention; Quinoxalines; Risk Factors | 1996 |
Analysis of foods for heterocyclic aromatic amine carcinogens by solid-phase extraction and high-performance liquid chromatography.
Topics: Amines; Animals; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Heterocyclic Compounds; Imidazoles; Meat; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet | 1997 |
The ability of two cooked food mutagens to induce aberrant crypt foci in mice.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colon; Cooking; Deoxyguanosine; Diet; Disease Models, Animal; Female; Food, Fortified; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Mice; Mice, Inbred C57BL; Mutagens; Quinoxalines; Reference Values; Weight Gain | 1997 |
Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken.
Topics: Amines; Animals; Chickens; Chromatography, High Pressure Liquid; Cooking; Food Analysis; Heterocyclic Compounds; Imidazoles; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium | 1997 |
Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity.
Topics: Animals; Arylamine N-Acetyltransferase; Cattle; Cytochrome P-450 CYP1A2; Female; Hot Temperature; Humans; Imidazoles; Male; Meat; Phenotype; Quinoxalines | 1997 |
Quantification of mutagenic/carcinogenic heterocyclic amines, MeIQx, Trp-P-1, Trp-P-2 and PhIP, contributing highly to genotoxicity of river water.
Topics: Amines; Animals; Carbolines; Carcinogens; Cellulose; Chromatography, High Pressure Liquid; Fresh Water; Imidazoles; In Vitro Techniques; Japan; Mutagenicity Tests; Mutagens; Quinoxalines; Rats; Salmonella typhimurium; Water Pollutants, Chemical | 1997 |
Assessment of the human exposure to heterocyclic amines.
Topics: Aged; Carcinogens; Female; Food Handling; Hot Temperature; Humans; Imidazoles; Male; Middle Aged; Mutagens; Quinolines; Quinoxalines | 1997 |
In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse.
Topics: Amines; Animals; Brain; Carbolines; DNA Damage; Electrophoresis; Imidazoles; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Quinolines; Quinoxalines; Stomach | 1997 |
Characterization of the carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in cooking aerosols under domestic conditions.
Topics: Aerosols; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Dose-Response Relationship, Drug; Mass Spectrometry; Mutagenicity Tests; Quinoxalines; Salmonella typhimurium | 1998 |
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
Topics: Amines; Animals; Anticarcinogenic Agents; Antioxidants; Biological Assay; Carcinogens; Hydroquinones; Imidazoles; Liver Neoplasms, Experimental; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344 | 1998 |
Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines.
Topics: Animals; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Jejunum; Lactobacillus; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344; Streptococcus | 1998 |
DNA damage in isolated rat hepatocytes exposed to C.I. pigment orange 5 and C.I. pigment yellow 12 by the alkaline comet assay.
Topics: Alkalies; Animals; Azo Compounds; Biotransformation; Cell Separation; Coloring Agents; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis; Female; Liver; Mutagenicity Tests; Quinoxalines; Rats; Rats, Wistar | 1998 |
[Effects of 16-week dietary administration of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in rats].
Topics: Animals; Carcinogens; Diet; Intestines; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344 | 1997 |
Effect of some cooked food mutagens on unscheduled DNA synthesis in cultured precision-cut rat, mouse and human liver slices.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Autoradiography; Carbolines; Cooking; Culture Techniques; DNA; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Liver; Male; Mice; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1998 |
Inhibitory effects of antioxidants on formation of heterocyclic amines.
Topics: Animals; Antimutagenic Agents; Antioxidants; Biotransformation; Imidazoles; Mutagens; Quinoxalines; Rats; Tea | 1998 |
Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses. Comparison of human subjects and F344 rats.
Topics: Adult; Aged; Animals; Carbon Radioisotopes; Carcinogens; Dose-Response Relationship, Drug; Hemoglobins; Humans; Male; Mass Spectrometry; Protein Binding; Quinoxalines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Serum Albumin | 1998 |
Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.
Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Humans; Imidazoles; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1998 |
Inhibitory effect of threo-9,10-dichlorostearic acid on the mutagenic activity of MeIQx, 2-AF and B[a]P in the Ames/Salmonella test.
Topics: 4-Nitroquinoline-1-oxide; Antimutagenic Agents; Benzo(a)pyrene; Fluorenes; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium; Stearic Acids | 1998 |
Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification.
Topics: DNA Adducts; Imidazoles; Mass Spectrometry; Quinoxalines; Sensitivity and Specificity | 1998 |
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.
Topics: Animals; Biotransformation; Carbolines; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Damage; Dose-Response Relationship, Drug; Fibroblasts; Food; Hot Temperature; Humans; Imidazoles; Lymphocytes; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Structure-Activity Relationship | 1999 |
Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American men in Los Angeles County.
Topics: Adult; Asian; Black People; Humans; Imidazoles; Los Angeles; Male; Meat; Neoplasms; Quinoxalines; Surveys and Questionnaires; White People | 1999 |
Mechanism of oxidative DNA damage induced by a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Amines; Animals; Catalase; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Copper; Cytosine; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Genes, p53; Genes, ras; Hydrogen Peroxide; Models, Chemical; NAD; Oxidation-Reduction; Phenanthrolines; Quinoxalines; Spectrum Analysis; Thymine | 1999 |
Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.
Topics: Amines; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Isoquinolines; Mutagenicity Tests; Mutagens; NADPH-Ferrihemoprotein Reductase; Plasmids; Quinolines; Quinoxalines; Salmonella typhimurium | 1999 |
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
Topics: Animals; Animals, Newborn; Biological Assay; Carcinogens; Imidazoles; Mice; Neoplasms, Experimental; Quinoxalines; Risk | 1999 |
N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epithelium.
Topics: Arylamine N-Acetyltransferase; Carcinogens; DNA; DNA Adducts; Epithelial Cells; Humans; Imidazoles; Isoenzymes; Male; Prostate; Prostatic Hyperplasia; Pyridines; Quinoxalines | 1999 |
Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys.
Topics: Animals; Carcinogens; Cytochrome P-450 CYP1A2; DNA Adducts; Female; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Macaca fascicularis; Male; Neoplasms, Experimental; Quinoxalines | 1999 |
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines.
Topics: Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Gene Expression; Humans; Imidazoles; Mutagenicity Tests; Mutagens; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Plasmids; Quinoxalines; Salmonella | 1999 |
Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH.
Topics: Cytochrome Reductases; Cytochrome-B(5) Reductase; DNA Damage; Free Radicals; Humans; NAD; Quinolines; Quinoxalines; Recombinant Proteins | 1999 |
Biomonitoring of heterocyclic aromatic amine metabolites in human urine.
Topics: Humans; Mutagens; Quinoxalines; Urinalysis | 1999 |
Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses.
Topics: Animals; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Humans; Imidazoles; Macromolecular Substances; Mice; Quinoxalines; Rats | 1999 |
Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment.
Topics: Animals; Carcinogens; Diet; Food Contamination; Glutathione Transferase; Humans; Liver; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 1999 |
Comparative biotransformation studies of MeIQx and PhIP in animal models and humans.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Colon; DNA Adducts; Humans; Imidazoles; Quinoxalines; Rats; Species Specificity | 1999 |
Role of well-done, grilled red meat, heterocyclic amines (HCAs) in the etiology of human cancer.
Topics: Carcinogens; Colorectal Neoplasms; Humans; Imidazoles; Meat Products; Quinoxalines | 1999 |
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Experimental; Male; Phosphodiesterase Inhibitors; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1999 |
Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models.
Topics: Animals; DNA, Complementary; Genes, myc; Mice; Mice, Transgenic; Mutagenesis; Mutagens; Neoplasms, Experimental; Quinolines; Quinoxalines; Transforming Growth Factor alpha | 1999 |
N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine.
Topics: Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Humans; Hydroxylamines; Mutagens; Oxidation-Reduction; Phenotype; Quinoxalines | 1999 |
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cell Survival; CHO Cells; Cricetinae; Heterocyclic Compounds; Humans; Imidazoles; Liver Neoplasms; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella; Tumor Cells, Cultured | 1999 |
Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments.
Topics: Animals; Animals, Genetically Modified; Benzo(a)pyrene; DNA Mutational Analysis; Dose-Response Relationship, Drug; Escherichia coli Proteins; Ethylnitrosourea; Female; Gene Dosage; Genetic Vectors; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Ribosomal Protein S9; Transgenes; Water Pollutants, Chemical; Zebrafish | 2000 |
Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype.
Topics: Adult; Aged; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; Cooking; Diet; Female; Genotype; Humans; Imidazoles; Meat; Middle Aged; Mutagens; Quinoxalines; Risk Factors | 2000 |
In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.
Topics: Administration, Oral; Animals; Bacterial Proteins; Cell Division; Colon; Diet; Dose-Response Relationship, Drug; Escherichia coli Proteins; Female; Intubation, Gastrointestinal; Lac Repressors; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Repressor Proteins; Reticulocytes; Sex Factors | 2000 |
Dietary heterocyclic amines and the risk of lung cancer among Missouri women.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Diet; Female; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Lung Neoplasms; Middle Aged; Missouri; Multivariate Analysis; Quinoxalines; Risk Factors; Smoking | 2000 |
Enhancing effects of Thai edible plants on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Plants, Medicinal; Quinoxalines; Rats; Rats, Inbred F344; Thailand | 2000 |
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Experimental; Organ Size; Precancerous Conditions; Propolis; Quinoxalines; Random Allocation; Rats; Rats, Inbred F344; Water | 2000 |
Gel microdrop flow cytometry assay for low-dose studies of chemical and radiation cytotoxicity.
Topics: Animals; Cell Survival; CHO Cells; Clone Cells; Colony-Forming Units Assay; Cricetinae; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Gamma Rays; Gels; Humans; Mice; Quinoxalines | 2001 |
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.
Topics: Animals; Biotransformation; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Mutagens; Quinoxalines; Rats; Theophylline | 2001 |
The food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: a conformational analysis of its major DNA adduct and comparison with the 2-amino-3-methylimidazo[4,5-f]quinoline adduct.
Topics: Animals; Carcinogens; Computer Simulation; DNA Adducts; DNA Replication; Molecular Structure; Mutagens; Nucleic Acid Conformation; Quinolines; Quinoxalines | 2001 |
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.
Topics: Animals; Antimutagenic Agents; Catechin; Chromatography, High Pressure Liquid; Cooking; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Tea | 2001 |
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
Topics: Amines; Animals; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Inactivation, Metabolic; Kinetics; Microsomes, Liver; Mutagens; NADPH-Ferrihemoprotein Reductase; Quinoxalines; Rats; Recombinant Proteins; Species Specificity; Substrate Specificity; Theophylline | 2001 |
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbolines; Catalysis; Cell Transformation, Neoplastic; COS Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Escherichia coli; Lac Operon; Quinolines; Quinoxalines; Substrate Specificity | 2001 |
Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.
Topics: Adult; Biomarkers; Biotransformation; Brassica; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Deoxyguanosine; DNA; Humans; Imidazoles; Lymphocytes; Male; Meat; Middle Aged; Quinoxalines | 2001 |
Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.
Topics: Animals; Carcinogens; Colonic Neoplasms; Genes, ras; Male; Mutagens; Mutation; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344; Tumor Suppressor Protein p53 | 2001 |
Mutational spectra of benzo[a]pyrene and MeIQx in rpsL transgenic zebrafish embryos.
Topics: Animals; Animals, Genetically Modified; Benzo(a)pyrene; Mutagens; Mutation; Quinoxalines; Ribosomal Proteins; Zebrafish | 2002 |
Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes.
Topics: Cytochrome P-450 CYP1A2; Hepatocytes; Humans; Molecular Structure; Mutagens; Oxidation-Reduction; Quinoxalines; Tumor Cells, Cultured | 2001 |
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Immunoblotting; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Smoking | 2002 |
Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats.
Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; DNA; DNA Damage; DNA Primers; DNA-Formamidopyrimidine Glycosylase; Glutathione Transferase; Guanosine; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; N-Glycosyl Hydrolases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Transaminases | 2002 |
Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization | 2002 |
Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex.
Topics: Animals; Carcinogens; Eating; Female; Genotype; Harmine; Hot Temperature; Imidazoles; Male; Meat; Mutagens; Quinoxalines; Sex Characteristics; Swine | 2002 |
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
Topics: Animals; Antinematodal Agents; Arylamine N-Acetyltransferase; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2; DNA Primers; Drug Combinations; Drug Synergism; Enzyme Induction; Fenbendazole; Glutathione Transferase; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Arylsulfotransferase; Carcinogens; Case-Control Studies; Colorectal Neoplasms; Cooking; Cytochrome P-450 CYP2A6; Diet; Eating; Environmental Exposure; Female; Genotype; Glutathione Transferase; Humans; Imidazoles; Male; Meat Products; Middle Aged; Mixed Function Oxygenases; Polymerase Chain Reaction; Quinoxalines; Sulfotransferases | 2002 |
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Imidazoles; Liver; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Species Specificity; Theophylline | 2002 |
Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan.
Topics: Adult; Amines; Carcinogens; Cooking; Diet Surveys; Female; Heterocyclic Compounds; Humans; Imidazoles; Japan; Male; Meat; Middle Aged; Population; Prospective Studies; Quinolines; Quinoxalines | 2002 |
Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.
Topics: Aflatoxin B1; Anthraquinones; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carmine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Escherichia coli; Humans; Mutagens; Quinoxalines; Recombinant Proteins; Salmonella typhimurium | 2002 |
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 2002 |
Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Enzyme Induction; Glucuronosyltransferase; Imidazoles; Liver; Liver Neoplasms, Experimental; Male; Membrane Proteins; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Smoke; Specific Pathogen-Free Organisms; Steroid Hydroxylases; Substrate Specificity | 2003 |
A model system study of the inhibition of heterocyclic aromatic amine formation by organosulfur compounds.
Topics: Allyl Compounds; Amines; Creatinine; Disulfides; Glucose; Heterocyclic Compounds; Hot Temperature; Imidazoles; Phenylalanine; Quinoxalines; Sulfites; Sulfur Compounds; Volatilization | 2002 |
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 2003 |
Effect of high water-holding capacity on the formation of heterocyclic amines in fried beefburgers.
Topics: Animals; Carcinogens; Cattle; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Quinoxalines; Water | 2003 |
Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods.
Topics: Amines; Animals; Animals, Domestic; Carcinogens; Food Analysis; Heterocyclic Compounds; Imidazoles; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium | 2003 |
Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.
Topics: Animals; Bacterial Proteins; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Escherichia coli Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagens; Mutation; Pentosyltransferases; Proteins; Quinoxalines | 2003 |
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cysteine; Deoxyguanosine; DNA; Genes, p53; Insulin-Like Growth Factor I; Liver Neoplasms, Experimental; Male; Nucleolus Organizer Region; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 2003 |
Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Antimutagenic Agents; Cell Line; Cricetinae; Imidazoles; Mutagens; Phytoalexins; Plant Extracts; Quinoxalines; Resveratrol; Sesquiterpenes; Stilbenes; Terpenes | 2004 |
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
Topics: alpha-Fetoproteins; Animals; beta Catenin; Cell Cycle Proteins; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Deletion; Gene Frequency; Genes, myc; Genomic Instability; Liver Neoplasms; Loss of Heterozygosity; Mice; Mice, Transgenic; Mutation; Phenotype; Quinoxalines; Trans-Activators; Transcription Factors; Transforming Growth Factor alpha | 2004 |
Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.
Topics: Amines; Animals; Carbolines; Carcinogens; Cooking; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Female; Harmine; Heterocyclic Compounds; Humans; Meat; Mutagens; Quinoxalines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2004 |
No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.
Topics: Animals; Animals, Genetically Modified; Body Weight; Carcinogenicity Tests; Carcinogens; Colorimetry; Cooking; DNA; Glutathione Transferase; Immunohistochemistry; Liver; Male; Mutagenicity Tests; Mutagens; No-Observed-Adverse-Effect Level; Organ Size; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344 | 2004 |
Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.
Topics: Amines; Animals; Carbolines; Cattle; Chromatography, Liquid; Food; Heterocyclic Compounds; Humans; Male; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Spectrometry, Mass, Electrospray Ionization | 2004 |
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Imidazoles; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Restriction Mapping; Trans-Activators | 2005 |
Heterocyclic amines in some Swedish cooked foods industrially prepared or from fast food outlets and restaurants.
Topics: Amines; Animals; Carcinogens; Cooking; Food Analysis; Food Handling; Heterocyclic Compounds; Imidazoles; Meat; Mutagens; Quinolines; Quinoxalines; Restaurants; Sweden | 2004 |
Effect of the South African traditional meat, biltong, on cancer-associated enzymes CYP2E1 and CYP1A2.
Topics: Adult; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Diet; Female; Humans; Male; Meat; Quinoxalines; South Africa | 2004 |
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Deoxyguanosine; Diet; DNA Adducts; Female; Glutathione Transferase; Humans; Lactation; Liver; Liver Neoplasms, Experimental; Male; Milk, Human; Placenta; Precancerous Conditions; Pregnancy; Quinoxalines; Rats; Rats, Inbred F344 | 2004 |
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diet; Drug Therapy, Combination; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinolines; Quinoxalines | 2005 |
A comparison of genotoxicity between three common heterocyclic amines and acrylamide.
Topics: Acrylamide; Animals; Dose-Response Relationship, Drug; Erythrocytes; Heterocyclic Compounds; Imidazoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Mutagens; Quinolines; Quinoxalines; Structure-Activity Relationship | 2005 |
Addition of various carbohydrates to beef burgers affects the formation of heterocyclic amines during frying.
Topics: Animals; Carbohydrates; Cattle; Chemical Phenomena; Chemistry, Physical; Dietary Fiber; Heterocyclic Compounds; Hot Temperature; Meat; Quinoxalines; Solanum tuberosum; Starch | 2004 |
Inhibitory effects of heterocyclic amine-induced DNA adduct formation in mouse liver and lungs by beer.
Topics: Animals; Beer; Carbolines; DNA Adducts; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mutagens; Quinoxalines | 2005 |
Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians.
Topics: Creatinine; Diet, Vegetarian; Humans; Imidazoles; Male; Meat; Mutagens; Quinoxalines; Spectrometry, Mass, Electrospray Ionization | 2005 |
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Quinolines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Nitric oxide-mediated nitrosation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline potentiated by hemin and myeloperoxidase.
Topics: Animals; Carcinogens; Cattle; Cells, Cultured; Drug Synergism; Hemin; Humans; Neutrophils; Nitrosation; Peroxidase; Quinoxalines; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization | 2005 |
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa.
Topics: Animals; Body Weight; Chlorella; Diet; Diethylnitrosamine; Eating; Glutathione Transferase; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Treatment Outcome | 2005 |
Novel antimutagenic factors derived from the edible mushroom Agrocybe cylindracea.
Topics: Agaricales; Animals; Antimutagenic Agents; DNA Damage; Drosophila; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium | 2005 |
Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
Topics: Adenoma; Aged; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Female; Food Preservation; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Quinoxalines | 2005 |
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.
Topics: Adenoma; Administration, Oral; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP2E1; DNA Damage; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Liver Neoplasms; Male; Quinoxalines; Rats; Rats, Inbred F344; RNA, Messenger | 2005 |
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cysteine; Down-Regulation; Glutathione Transferase; Insulin-Like Growth Factor I; Liver Neoplasms; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Silver Staining; Time Factors | 2006 |
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.
Topics: Animals; Carcinogens; Glutathione S-Transferase pi; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred BN; Rats, Inbred F344 | 2006 |
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
Topics: Acetyltransferases; Animals; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Male; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Proteoglycans; Quinoxalines; Rats; Rats, Inbred F344; Syndecan-2 | 2006 |
Stability and reactivity of 2-nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Imidazoles; Liver; Male; Mice; Mice, Inbred C57BL; Nitrosamines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor.
Topics: Binding, Competitive; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Furans; Hot Temperature; Humans; Imidazoles; Meat; Quinoxalines | 2005 |
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
Topics: Acetylation; Arylamine N-Acetyltransferase; Carcinogens; Genotype; Humans; Imidazoles; Phenotype; Polymorphism, Single Nucleotide; Quinoxalines | 2006 |
Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Central Nervous System Depressants; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Ethanol; Glutathione S-Transferase pi; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344 | 2006 |
Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats.
Topics: 5-Methylcytosine; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Immunohistochemistry; Liver Diseases; Liver Neoplasms, Experimental; Male; Quinoxalines; Rats; Thioacetamide | 2006 |
Enhancement of phase II enzyme activity by purpurin resulting in the suppression of MeIQx-DNA-adduct formation in mice.
Topics: Animals; Anthraquinones; DNA Adducts; Male; Mice; Mice, Inbred C57BL; Quinoxalines | 2007 |
Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure.
Topics: Amines; Animals; Cattle; Cooking; Heterocyclic Compounds; Imidazoles; Meat; Mutagens; Quinoxalines | 2007 |
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Profiling; Liver; Liver Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344 | 2007 |
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
Topics: Acetylation; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Carcinogens; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Damage; DNA Repair; Gene Expression Regulation, Enzymologic; Humans; Mutagenesis; Mutation; Quinoxalines; Tandem Mass Spectrometry; Transfection | 2007 |
Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties.
Topics: Animals; Antioxidants; Catechin; Cattle; Chromatography, High Pressure Liquid; Cinnamates; Creatinine; Depsides; Diet; Flavanones; Flavonoids; Glucose; Imidazoles; Meat; Models, Chemical; Phenols; Phenylalanine; Polyphenols; Quinoxalines; Rosmarinic Acid | 2007 |
Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China.
Topics: Animals; Carbolines; Carcinogens; Case-Control Studies; Chickens; China; Cohort Studies; Creatinine; Follow-Up Studies; Humans; Imidazoles; Male; Meat; Middle Aged; Population Surveillance; Prospective Studies; Quinoxalines; Smoking; Swine | 2007 |
What is a practical threshold?
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Glutathione S-Transferase pi; Liver; Quinoxalines; Rats | 2007 |
Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties.
Topics: Animals; Carcinogens; Cattle; Citrus; Fruit; Garlic; Heterocyclic Compounds; Hot Temperature; Meat; Olive Oil; Onions; Plant Oils; Quinoxalines | 2007 |
Inhibitory effect of fruit extracts on the formation of heterocyclic amines.
Topics: Ananas; Animals; Cattle; Fruit; Heterocyclic Compounds; Hot Temperature; Imidazoles; Malus; Meat; Plant Extracts; Proanthocyanidins; Quinoxalines; Sambucus; Seeds; Vitis | 2007 |
Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study.
Topics: Case-Control Studies; Cohort Studies; Cooking; Diet; Humans; Male; Meat; Middle Aged; Mutagens; Polycyclic Aromatic Hydrocarbons; Prospective Studies; Prostatic Neoplasms; Quinoxalines | 2008 |
Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial.
Topics: Anticarcinogenic Agents; Antimutagenic Agents; Carbolines; Carcinogens; Food Handling; Heterocyclic Compounds; Hot Temperature; Imidazoles; Lactobacillus; Meat; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines | 2008 |
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Cell Line; Dantrolene; Dogs; Imidazoles; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Prazosin; Quinoxalines; Swine; Testis; Triamterene; Xenobiotics | 2008 |
Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.
Topics: Amines; Animals; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Glutathione Transferase; Hepatocytes; Heterocyclic Compounds; Imidazoles; Liver; Liver Neoplasms; Male; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Risk | 2008 |
Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma, Liver Cell; Administration, Oral; Animal Feed; Animals; Carcinogens; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Liver Neoplasms; Longevity; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344 | 2008 |
Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.
Topics: Amines; Animals; Carbolines; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Mutagens; Quinoxalines | 2008 |
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Diethylnitrosamine; Female; Glutathione Peroxidase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Animal; Organ Size; Quinoxalines; Rats; Rats, Inbred F344 | 2008 |
Effect of beer/red wine marinades on the formation of heterocyclic aromatic amines in pan-fried beef.
Topics: Animals; Beer; Carcinogens; Cattle; Food Handling; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Meat; Quinolines; Quinoxalines; Sensation; Wine | 2008 |
Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Cells, Cultured; DNA Adducts; Hepatocytes; Humans; Liver; Male; Mouth Mucosa; Quinoxalines; Rats; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2009 |
Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk.
Topics: Aged; Animals; Case-Control Studies; Cattle; Chickens; Female; Humans; Imidazoles; Italy; Lung Neoplasms; Male; Meat; Meat Products; Middle Aged; Mutagens; Quinoxalines | 2009 |
Ability of probiotic Lactobacillus casei DN 114001 to bind or/and metabolise heterocyclic aromatic amines in vitro.
Topics: Amines; Aminopyridines; Analysis of Variance; Cells, Cultured; Chromatography, High Pressure Liquid; Colony Count, Microbial; Comet Assay; DNA Damage; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Inactivation, Metabolic; Lacticaseibacillus casei; Mutagens; Probiotics; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet; Time Factors | 2009 |
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcinogens; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Female; Gene Targeting; Genetic Predisposition to Disease; Imidazoles; Liver Neoplasms; Mutagens; Polymorphism, Genetic; Quinoxalines; Rats; Rats, Inbred F344; Rats, Inbred WKY; Time Factors | 2009 |
Hollow fibre-supported liquid membrane extraction and LC-MS/MS detection for the analysis of heterocyclic amines in urine samples.
Topics: Analytic Sample Preparation Methods; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Harmine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Imidazoles; Limit of Detection; Microchemistry; Mutagens; Pyridines; Quinoxalines; Reproducibility of Results; Tandem Mass Spectrometry | 2009 |
Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
Topics: Animals; Arylamine N-Acetyltransferase; Base Sequence; CHO Cells; Cricetinae; Cricetulus; DNA Damage; Humans; Molecular Sequence Data; Mutagenesis; Mutagens; Quinolines; Quinoxalines; Transfection | 2010 |
A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.
Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Imidazoles; Meat; Metabolome; Quinoxalines; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2010 |
A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.
Topics: Cohort Studies; Colorectal Neoplasms; Cooking; Diet; Female; Humans; Imidazoles; Male; Meat; Middle Aged; Prospective Studies; Quinoxalines; Surveys and Questionnaires; United States | 2010 |
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cytochrome P-450 Enzyme System; DNA Damage; Dose-Response Relationship, Drug; Humans; Imidazoles; Oxidative Stress; Polymerase Chain Reaction; Quinoxalines | 2010 |
Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.
Topics: Adult; Breast Neoplasms; Cohort Studies; Female; Humans; Imidazoles; Meat; Middle Aged; Mutagens; Nurses; Postmenopause; Quinoxalines; Risk Factors; Surveys and Questionnaires | 2010 |
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression.
Topics: Analysis of Variance; Animals; Arylamine N-Acetyltransferase; Benzoflavones; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochromes; Drug Synergism; Enzyme Inhibitors; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Organ Specificity; Quinoxalines; Rats; Rats, Inbred F344 | 2010 |
Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary.
Topics: Animals; Antioxidants; Cattle; Cooking; Ethanol; Food Analysis; Food Handling; Gas Chromatography-Mass Spectrometry; Heterocyclic Compounds, 2-Ring; Imidazoles; Meat Products; Plant Extracts; Quinoxalines; Rosmarinus; Solid Phase Microextraction; Time Factors; Water | 2010 |
Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage.
Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Imidazoles; Oxidation-Reduction; Quinoxalines | 2011 |
Capillary liquid chromatography with diode array and mass spectrometry detection for heterocyclic aromatic amine determination in ready-to-eat food treated with electron-beam irradiation.
Topics: Acetonitriles; Animals; Cheese; Chromatography, Liquid; Food Analysis; Food Irradiation; Harmine; Linear Models; Mass Spectrometry; Quinoxalines; Reproducibility of Results; Salmon; Seafood; Sensitivity and Specificity | 2010 |
Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.
Topics: Amines; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Quinoxalines; Receptors, Aryl Hydrocarbon | 2010 |
Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Topics: Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Drug Synergism; Escherichia coli Proteins; Female; Genotype; Liver; Mice; Mice, Transgenic; Microsomes, Liver; Mutagens; Organ Size; Pentosyltransferases; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2010 |
Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice.
Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dextran Sulfate; Escherichia coli Proteins; Male; Mice; Mice, Transgenic; Mutagens; Pentosyltransferases; Quinoxalines; Tumor Suppressor Protein p53 | 2010 |
Meat consumption and risk of esophageal and gastric cancer in a large prospective study.
Topics: Adenocarcinoma; Aged; Carcinogens; Carcinoma, Squamous Cell; Cardia; Esophageal Neoplasms; Feeding Behavior; Female; Follow-Up Studies; Humans; Iron; Male; Meat; Middle Aged; Mutagens; Odds Ratio; Prospective Studies; Quinoxalines; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; United States | 2011 |
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
Topics: Aged; Amines; Aryl Hydrocarbon Receptor Nuclear Translocator; Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Case-Control Studies; Colorectal Neoplasms; Female; Genetic Variation; Genotype; Humans; Imidazoles; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Polymorphism, Single Nucleotide; Quinoxalines; Risk Factors | 2011 |
Selected heterocyclic amines.
Topics: Amines; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Environmental Exposure; Female; Government Regulation; Guidelines as Topic; Heterocyclic Compounds; Humans; Imidazoles; Macaca fascicularis; Male; Mice; Models, Biological; Quinolines; Quinoxalines; Rats; United States | 2004 |
Ultraperformance liquid chromatography-tandem mass spectrometry method for biomonitoring cooked meat carcinogens and their metabolites in human urine.
Topics: Carcinogens; Chromatography, Liquid; Cooking; Humans; Imidazoles; Meat; Molecular Structure; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urinalysis | 2011 |
Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study.
Topics: Adult; Aged; Breast Neoplasms; Carcinogens; Case-Control Studies; Cooking; Eating; Female; Humans; Meat; Middle Aged; Mutagens; Postmenopause; Premenopause; Quinoxalines; Regression Analysis; Risk Factors; Tennessee | 2011 |
Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice.
Topics: Animals; Antimutagenic Agents; DNA Adducts; Fruit; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mutagens; Phenols; Quinoxalines; Vitis | 2011 |
In vitro mutagen binding and antimutagenic activity of human Lactobacillus rhamnosus 231.
Topics: Acridine Orange; Antimutagenic Agents; Biotransformation; Culture Media; Feces; Humans; Hydrogen-Ion Concentration; Lacticaseibacillus rhamnosus; Methylnitronitrosoguanidine; Microbial Viability; Mutagens; Phenylenediamines; Quinoxalines | 2011 |
Inhibitory activity of Asian spices on heterocyclic amines formation in cooked beef patties.
Topics: Amines; Animals; Antioxidants; Cattle; Cooking; Curcuma; Hot Temperature; Imidazoles; Meat Products; Oils, Volatile; Phenols; Plant Extracts; Quinoxalines; Rosmarinus; Spices | 2011 |
Cytochrome P450-mediated metabolism and DNA binding of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline and its carcinogenic isomer 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in mice.
Topics: Animals; Carcinogens; Colon; Cytochrome P-450 Enzyme System; DNA Adducts; Female; Humans; Liver; Mice; Mice, Inbred C57BL; Microsomes, Liver; Pancreas; Quinoxalines; Recombinant Proteins; Rectum | 2012 |
[Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography].
Topics: Amines; Animals; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Food Contamination; Heterocyclic Compounds; Imidazoles; Poultry Products; Quinoxalines; Solid Phase Extraction | 2011 |
Occurrence of heterocyclic amines in cooked meat products.
Topics: Amines; Animals; Cattle; Chickens; Chromatography, High Pressure Liquid; Consumer Product Safety; Cooking; Fishes; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat Products; Mutagens; Quinoxalines; Risk Factors; Swine | 2012 |
Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells.
Topics: Cell Line, Tumor; Comet Assay; Flavonoids; Genomic Instability; Humans; Imidazoles; Mutagens; Propiophenones; Quinoxalines; Real-Time Polymerase Chain Reaction; Salmonella typhimurium | 2012 |
Plant extracts, spices, and essential oils inactivate Escherichia coli O157:H7 and reduce formation of potentially carcinogenic heterocyclic amines in cooked beef patties.
Topics: Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Carcinogens; Cattle; Clove Oil; Escherichia coli O157; Fruit; Hot Temperature; Imidazoles; Malus; Meat; Oils, Volatile; Olea; Onions; Plant Extracts; Quinoxalines; Spices | 2012 |
Formation of heterocyclic amines during cooking of duck meat.
Topics: Amines; Animals; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Ducks; Food Contamination; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Maillard Reaction; Meat; Microwaves; Mutagens; Quinolines; Quinoxalines; Solid Phase Extraction; Time Factors | 2012 |
Meat intake and risk of non-Hodgkin lymphoma.
Topics: Adult; Aged; Arylamine N-Acetyltransferase; Case-Control Studies; Dietary Fats; Female; Humans; Isoenzymes; Lymphoma, Non-Hodgkin; Male; Meat; Middle Aged; Mutagens; Oleic Acid; Quinoxalines; Risk Factors; United States | 2012 |
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.
Topics: Animals; beta-Naphthoflavone; Carbon Tetrachloride; Carcinogens; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Drug Synergism; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Omeprazole; Proton Pump Inhibitors; Quinoxalines; Rats; Rats, Inbred F344 | 2012 |
[Determination of 14 heterocyclic aromatic amines in wine by liquid chromatography-ion trap-time of flight tandem mass spectrometry].
Topics: Amines; Chromatography, Liquid; Food Contamination; Heterocyclic Compounds; Imidazoles; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Wine | 2012 |
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Female; Food; Genomic Instability; Humans; Imidazoles; Long Interspersed Nucleotide Elements; Mice; Quinoxalines; Receptors, Aryl Hydrocarbon | 2013 |
Meat-related compounds and colorectal cancer risk by anatomical subsite.
Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cooking; Feeding Behavior; Female; Humans; Imidazoles; Logistic Models; Male; Meat; Meat Products; Middle Aged; Nitrates; Nitrites; Pennsylvania; Poultry; Quinoxalines; Rectal Neoplasms; Risk Factors; Surveys and Questionnaires | 2013 |
Formation of heterocyclic amines in salami and ham pizza toppings during baking of frozen pizza.
Topics: Amines; Animals; Carbolines; Chromatography, High Pressure Liquid; Color; Consumer Behavior; Cooking; Freezing; Harmine; Hot Temperature; Humans; Imidazoles; Maillard Reaction; Meat Products; Quinoxalines; Swine; Taste | 2013 |
Helicobacter pylori infection and antioxidants can modulate the genotoxic effects of heterocyclic amines in gastric mucosa cells.
Topics: Adult; Ascorbic Acid; Breath Tests; Carbon Isotopes; Comet Assay; DNA Damage; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Imidazoles; Male; Melatonin; Middle Aged; Poland; Quinoxalines; Statistics, Nonparametric | 2013 |
Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.
Topics: Animals; Body Weight; Cell Proliferation; Cyclin D1; Cytochrome P-450 CYP1A2; Drug Synergism; Fluoroquinolones; Glucuronosyltransferase; Hepatocytes; Liver; Male; Mice; Mice, Transgenic; Mutagens; Mutation; Oligonucleotide Array Sequence Analysis; Phenobarbital; Quinoxalines | 2013 |
Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells.
Topics: Biotransformation; Carcinogens; Cell Cycle; Cell Survival; DNA Breaks; DNA Damage; Food Contamination; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Hot Temperature; Humans; Imidazoles; Mutagens; Quinolines; Quinoxalines | 2013 |
Formation and mitigation of heterocyclic aromatic amines in fried pork.
Topics: Animals; Antioxidants; Carcinogens; China; Cooking; Fast Foods; Food Contamination; Food Preservatives; Heterocyclic Compounds; Imidazoles; Meat; Meat Products; Mutagens; Plant Extracts; Plant Leaves; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Sasa; Sus scrofa | 2013 |
Chemical state of heterocyclic aromatic amines in grilled beef: evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction.
Topics: Amines; Animals; Carbolines; Cattle; Cooking; Digestion; Humans; Hydrolysis; Imidazoles; Male; Meat; Mutagens; Quinolines; Quinoxalines; Solvents | 2013 |
Red meat-derived heterocyclic amines increase risk of colon cancer: a population-based case-control study.
Topics: Aged; Amines; Case-Control Studies; Colonic Neoplasms; Confidence Intervals; Cooking; Female; Humans; Logistic Models; Male; Meat; Middle Aged; Mutagens; Nutrition Assessment; Odds Ratio; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Risk Factors; Surveys and Questionnaires | 2013 |
Dietary vitamin E effects on the formation of heterocyclic amines in grilled lean beef.
Topics: Amines; Animals; Antioxidants; Cattle; Chromatography, High Pressure Liquid; Cooking; Diet; Harmine; Imidazoles; Meat; Muscle, Skeletal; Mutagens; Quinoxalines; Salmonella; Vitamin E | 2014 |
Effect of enhancement on the formation of heterocyclic amines in cooked pork loins: preliminary studies.
Topics: Amines; Animals; Cooking; Creatine; Heterocyclic Compounds; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Meat; Phosphates; Quinoxalines; Salts; Swine; Water | 2014 |
Optimised extraction of heterocyclic aromatic amines from blood using hollow fibre membrane liquid-phase microextraction and triple quadrupole mass spectrometry.
Topics: Animals; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Humans; Hydrogen-Ion Concentration; Imidazoles; Liquid Phase Microextraction; Meat; Mutagens; Polypropylenes; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Impact of different pan-frying conditions on the formation of heterocyclic aromatic amines and sensory quality in fried bacon.
Topics: Animals; Cooking; Food Handling; Imidazoles; Meat Products; Quinoxalines; Temperature | 2015 |
Effect of six Chinese spices on heterocyclic amine profiles in roast beef patties by ultra performance liquid chromatography-tandem mass spectrometry and principal component analysis.
Topics: Amines; Animals; Capsicum; Cattle; Chromatography, High Pressure Liquid; Cooking; Cuminum; Foeniculum; Food Analysis; Harmine; Heterocyclic Compounds; Imidazoles; Meat; Piper nigrum; Principal Component Analysis; Pyridines; Quinolines; Quinoxalines; Spices; Tandem Mass Spectrometry | 2014 |
Evaluation of maillard reaction variables and their effect on heterocyclic amine formation in chemical model systems.
Topics: Carbohydrates; Carcinogens; Chromatography, Reverse-Phase; Creatinine; Hot Temperature; Maillard Reaction; Meat; Models, Chemical; Mutagens; Quinolines; Quinoxalines; Threonine; Water | 2015 |
Impact of Precursors Creatine, Creatinine, and Glucose on the Formation of Heterocyclic Aromatic Amines in Grilled Patties of Various Animal Species.
Topics: Acids, Heterocyclic; Amines; Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Cooking; Creatine; Creatinine; Glucose; Horses; Hot Temperature; Humans; Imidazoles; Meat; Mutagens; Poultry; Pyridines; Quinoxalines; Sheep; Swine | 2015 |
Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Case-Control Studies; Disease Susceptibility; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Imidazoles; Kidney Neoplasms; Male; Meat; Middle Aged; Mutagens; Quinoxalines; Risk Factors; United States | 2016 |
Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans.
Topics: Case-Control Studies; Diet; DNA Adducts; Humans; Mutagens; Pancreatectomy; Pancreatic Neoplasms; Quinoxalines | 2016 |
Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.
Topics: Activation, Metabolic; Carbolines; Cell Culture Techniques; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adducts; Flow Cytometry; Humans; Imidazoles; Quinoxalines; Real-Time Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; T-Lymphocytes | 2016 |
Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.
Topics: Aged; Animals; Carcinogens; Cattle; Chromatography, Liquid; Cooking; DNA Adducts; Humans; Imidazoles; Limit of Detection; Male; Meat; Middle Aged; Nicotiana; Prostate; Quinoxalines; Smoke; Tandem Mass Spectrometry | 2016 |
Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.
Topics: Activation, Metabolic; Animals; Arylamine N-Acetyltransferase; Arylsulfotransferase; Cytochrome P-450 CYP1A2; Heterocyclic Compounds; Humans; Imidazoles; Mutagenicity Tests; Mutagens; Quinoxalines; Recombinant Proteins | 2017 |
Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency.
Topics: 3T3 Cells; Animals; Carcinogens; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred BALB C; Mutagens; Quinoxalines; Spectrum Analysis | 2017 |
Inhibition effects of flavonoids on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline formation and alkoxy radical scavenging capabilities of flavonoids in a model system.
Topics: Alcohols; Carcinogens; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Flavonoids; Free Radical Scavengers; Models, Chemical; Quinoxalines | 2018 |
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.
Topics: Amines; Animals; Carbolines; Dopaminergic Neurons; Dose-Response Relationship, Drug; Harmine; Heterocyclic Compounds, 3-Ring; Mesencephalon; Molecular Structure; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Quinolines; Quinoxalines; Rats | 2018 |
The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.
Topics: Adult; Amines; Animals; Carbolines; Feces; Female; Food Contamination; Gastrointestinal Microbiome; Glyceraldehyde; Harmine; Heterocyclic Compounds, Fused-Ring; Humans; Male; Microsomes, Liver; Middle Aged; Propane; Quinolines; Quinoxalines; Rats, Wistar | 2019 |
2-Amino-3,8-dimethylimidazo[4,5-
Topics: Animals; Autophagosomes; Cell Line; Embryonic Stem Cells; Humans; Lipid Metabolism; Lipids; Mice; Microtubule-Associated Proteins; Quinoxalines; Transcription Factors | 2019 |
Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport.
Topics: Animals; Biotransformation; Cell Line; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344 | 2019 |
Revealing a key inhibitory mechanism of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline via trapping of methylglyoxal.
Topics: Amines; Animals; Cooking; Fish Products; Hot Temperature; Hydroxybenzoates; Mutagens; Pyridoxamine; Pyruvaldehyde; Quinoxalines; Tilapia; Vitamins | 2020 |
Mitigation of heterocyclic aromatic amines in cooked meat. Part I: Informed selection of antioxidants based on molecular modeling.
Topics: Amines; Animals; Antioxidants; Cattle; Cooking; Heterocyclic Compounds; Models, Molecular; Origanum; Plant Extracts; Quinolines; Quinoxalines; Red Meat; Resveratrol; Structure-Activity Relationship; Tea; Wine | 2020 |
Identification of acrolein as the reactive carbonyl responsible for the formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Topics: Acrolein; Animals; Creatinine; Hot Temperature; Hydrogen-Ion Concentration; Quinoxalines | 2021 |
Effects of ten vegetable oils on heterocyclic amine profiles in roasted beef patties using UPLC-MS/MS combined with principal component analysis.
Topics: Amines; Animals; Cattle; Chromatography, High Pressure Liquid; Cooking; Heterocyclic Compounds; Imidazoles; Limit of Detection; Meat; Plant Oils; Principal Component Analysis; Quinoxalines; Tandem Mass Spectrometry | 2021 |