Page last updated: 2024-08-24

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with quinoxalines in 353 studies

Research

Studies (353)

TimeframeStudies, this research(%)All Research%
pre-199040 (11.33)18.7374
1990's163 (46.18)18.2507
2000's88 (24.93)29.6817
2010's58 (16.43)24.3611
2020's4 (1.13)2.80

Authors

AuthorsStudies
Jägerstad, M; Nielsen, LL; Nyman, M; Sjödin, P; Wallin, H1
Klungsøyr, L; Mjelva, BB; Vikse, R1
Akaike, T; Ando, M; Kojima, Y; Maeda, H; Nagao, M; Sato, K1
Brams, A; de Meester, C1
Alldrick, AJ; Brennan-Craddock, WE; Lake, BG; Rowland, IR1
Alldrick, AJ; Coutts, TM; Ho, TA; Rowland, IR1
Fay, LB; Turesky, RJ1
Boobis, AR; Davies, DS; Gooderham, NJ; Knize, MG; Lynch, AM; Murray, S1
Boobis, AR; Davies, DS; Gooderham, NJ; Lewis, I; Murray, BP; Rendell, NB; Rich, KJ1
Brandt, I; Brittebo, E; Eriksson, C; Gustafsson, JA; Overvik, E1
Adamson, RH; Schut, HA; Snyderwine, EG; Thorgeirsson, SS; Thorgeirsson, UP1
Felton, JS; Fultz, E; Knize, MG; Roper, M; Shen, NH; Turteltaub, KW1
Ilett, KF; Kadlubar, FF; Minchin, RF; Reeves, PT; Teitel, CH1
Alexander, J; Holme, JA; Wallin, H1
Aune, T; Ingebrigtsen, K; Tjøtta, K1
Kushida, H; Nagao, M; Sone, H; Sugimura, T; Wakabayashi, K1
Bucci, T; Dooley, KL; Fu, PP; Kadlubar, FF; Von Tungeln, LS1
Boobis, AR; Davies, DS; Gooderham, NJ; Rice, JC; Soames, A1
Gustafsson, JA; Kleman, M; Mason, G; Overvik, E1
Boncristiani, G; Loprieno, G; Loprieno, N2
Hirose, M; Itoh, H; Nagao, M; Sugimura, T; Ushiyama, H; Wakabayashi, K1
Butler, MA; Kadlubar, FF; Lang, NP; Teitel, CH; Turesky, RJ1
Bracco-Hammer, I; Fay, LB; Markovic, J; Turesky, RJ1
Hirose, M; Nagao, M; Ochiai, M; Overvik, E; Sugimura, T1
Buonarati, MH; Davis, JC; Felton, JS; Gledhill, BL; Turteltaub, KW; Vogel, JS1
Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, A; Murray, BP; Murray, S; Sesardic, D1
Esumi, H; Kudo, M; Ogura, T; Sugimura, T1
Fukushima, S; Hakoi, K; Hasegawa, R; Ito, N; Iwasaki, S; Nagao, M; Shirai, T; Sugimura, T; Takaba, K; Wakabayashi, K1
Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, AM; Murray, S1
Adachi, M; Kato, S; Nagao, M; Nakagama, H; Ochiai, M; Sato, S; Sugimura, T; Wakabayashi, K; Yamashita, K1
Adamson, RH; Schut, HA; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Turesky, RJ1
Baker, AJ; Gooderham, NJ; Morgan, JP; Srebernik, N1
Boobis, AR; Davies, DS; Gooderham, NJ; Murray, BP; Murray, S1
Boobis, AR; Davies, DS; Gooderham, NJ; Ponder, BA; Winton, DJ1
Gooderham, NJ; O'Farrell, FJ1
Ito, N; Ozaki, K; Takahashi, S; Tsuda, H; Yamaguchi, S1
Burgess, WM; Huggett, A; McManus, ME; Quattrochi, LC; Tukey, RH; Veronese, ME1
Caffee, MW; Davis, JC; Felton, JS; Finkel, RC; Gledhill, BL; Nelson, DE; Proctor, ID; Southon, JR; Turteltaub, KW; Vogel, JS1
Jägerstad, M; Skog, K2
Ayrton, AD; Flatt, PR; Ioannides, C; Keele, A; Lewis, DF; Walker, R1
Felton, JS; Turteltaub, KW; Vanderlaan, M; Watkins, BE1
Negishi, C; Sato, S; Yamaizumi, Z1
Blanck, A; Gustafsson, JA; Kleman, M; Overvik, E1
Aeschbacher, HU; Forster, CM; Skipper, PL; Tannenbaum, SR; Trudel, LJ; Turesky, RJ; Würzner, HP1
Alexander, J; Jägerstad, M; Sjödin, P; Wallin, H1
Alldrick, AJ; Lutz, WK1
Boobis, AR; Davies, DS; Gooderham, NJ; Murray, S3
Wada, O; Yanagisawa, H1
Alexander, J; Becher, G; Holme, JA; Wallin, H1
Aeschbacher, HU; Ruch, E1
Ayrton, AD; Bass, SL; Flatt, PR; Ioannides, C; Trinick, J; Walker, R1
Grivas, S; Kato, S; Sugimura, T; Umemoto, A; Yamashita, K1
Hayatsu, H; Kato, T; Kikugawa, K1
Abu-Zeid, M; Kato, R; Manabe, S; Toyama, S; Yamazoe, Y1
Aeschbacher, HU; Bur, H; Huynh-Ba, T; Milon, H; Turesky, RJ1
Alldrick, AJ; Rowland, IR1
Alexander, J; Wallin, H1
Kato, T; Kikugawa, K1
Alldrick, AJ; Rowland, IR; Wise, A1
Abu-Shakra, A; Ioannides, C; Walker, R1
Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Sugimura, T; Takayama, S1
Aeschbacher, HU; Malnoë, A; Turesky, RJ; Würzner, HP1
Aeschbacher, HU; Skipper, PL; Tannenbaum, SR; Turesky, RJ; Würzner, HP1
Liu, ZC; Nagao, M; Sugimura, T; Wakabayashi, K; Zhang, XM1
Arimoto, S; Hayatsu, H; Hayatsu, T; Kasai, H; Miyazawa, T; Nishimura, S; Ohara, Y; Sato, S; Yamaizumi, Z; Yokoyama, S1
Hasegawa, H; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S1
Davies, DS; Gooderham, NJ; Murray, S; Rice, JC; Taylor, GW; Watson, D1
Manabe, S; Wada, O; Yanagisawa, H1
Beamand, JA; Howes, AJ; Rowland, IR1
Ishikawa, S; Kitagawa, Y; Manabe, S; Nakajima, K; Wada, O; Yanagisawa, H1
Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S1
Caderni, G; Dolara, P; Salvadori, M; Santoni, G1
Grivas, S; Olsson, K1
Goto, T; Kinae, N; Masui, T; Nagao, M; Sugimura, T; Takahashi, M; Tomita, I; Wakabayashi, K; Yamamoto, M1
Hayatsu, H; Hayatsu, T; Matsui, Y; Ohara, Y; Oka, T1
Grivas, S; Jägerstad, M; Negishi, C; Olsson, K; Sato, S; Sugimura, T; Tsuda, M; Wakabayashi, K1
Buchi, GH; Pfund, RA; Tannenbaum, SR; Turesky, RJ; Wishnok, JS1
Hayashi, K; Kasai, H; Miyazawa, T; Nishimura, S; Watanabe, T; Yokoyama, S1
Diachenko, GW; Hargraves, WA; Jackson, LS; Stroup, WH1
Brown, ED; Davies, DS; Hoover, RN; Kadlubar, FF; Lang, NP; Levander, OA; Mark, SD; Murray, S; Rothman, N; Sinha, R1
Sadrieh, N; Snyderwine, EG1
Hirose, M; Kushida, H; Nagao, M; Ochiai, M; Sato, H; Sugimura, T; Wakabayashi, K1
Deguchi, T; Hashimoto, H; Itoh, S; Kamataki, T; Sawada, M; Yanagawa, Y1
Brown, ED; Cunningham, PL; Felton, JS; Knize, MG; Levander, OA; Rothman, N; Salmon, CP; Sinha, R1
Robertson, JA; Ryden, P2
Hao, NJ; Lee, H; Lin, MY1
Sasaki, YF; Shirasu, Y1
Ferguson, LR; Harris, PJ; Roberton, AM; Triggs, CM; Watson, ME1
Kato, R; Nagata, K; Ozawa, S; Yamazoe, Y1
Wild, D1
Davis, CD; Fay, LB; Snyderwine, EG; Turesky, RJ; Welti, DH1
Bangerter, C; Frantz, CE; Fultz, E; Mayer, KM; Turteltaub, KW; Vogel, JS1
Brown, ED; Caporaso, NE; Hoover, RN; Kadlubar, FF; Knize, MG; Lang, NP; Levander, OA; Mark, SD; Rothman, N; Sinha, R1
Dolbeare, FA; Felton, JS; Fultz, E; Knize, MG1
Deguchi, T; Gonzalez, FJ; Kamataki, T; Sawada, M; Yanagawa, Y1
Carroll, KL; Dolbeare, FA; Felton, JS; Knize, MG; Moore, DH1
Jägerstad, M; Johansson, MA1
Chiarelli, MP; Kaderlik, KR; Kadlubar, FF; Lang, NP; Mulder, GJ; Teitel, CH; Turesky, RJ1
Nagao, M; Oguri, A; Wakabayashi, K; Weisburger, JH1
Katami, M; Kurosaka, R; Kushida, H; Nagao, M; Sato, H; Wakabayashi, K1
Kadlubar, FF; Ketterer, B; Lang, NP; Lin, D; Meyer, DJ1
Boobis, AR; Brooks, RA; Edwards, RJ; Gooderham, NJ; Howard, LA; Winton, DJ; Zhao, K1
Boobis, AR; Davies, DS; Edwards, RJ; Gant, TW; Murray, BP; Murray, S; Neubert, D; Schulz, T; Thorgeirsson, SS1
Burgard, S; Edenharder, R; John, K; Kurz, P; Seeger, K1
Adamson, RH; Davis, CD; Snyderwine, EG1
Davis, CD; Schut, HA; Snyderwine, EG1
Blanck, A; Gustafsson, JA; Kleman, MI; Overvik, E; Porsch-Hällström, I1
Kim, SB; Nagao, M; Nagaoka, H; Nukaya, H; Ochiai, M; Sugimura, T; Tada, A; Tanaka, Y; Wakabayashi, K1
Ghoshal, A; Snyderwine, EG1
Fay, LB; Gross, GA; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ1
Shubik, P1
Boobis, AR; Davies, DS; de la Torre, R; Farré, M; Gooderham, NJ; Lynch, AM; Murray, S; Segura, J; Solans, A1
Banning, DP; Gooderham, NJ; O'Farrell, F1
Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ1
Hirose, M; Kim, SB; Nagao, M; Nukaya, H; Ochiai, M; Sugimura, T; Takahashi, M; Ushiyama, H; Wakabayashi, K1
Djanegara, T; Hwang, M; Vanderlaan, M1
Davis, CD; Nouso, K; Roller, PP; Schut, HA; Snyderwine, EG1
Alldrick, AJ; Hô, TA; Phillips, DH; Rowland, IR; She, MN1
Gooderham, MJ; Knize, MG; Lynch, AM; Murray, S1
Gustafsson, JA; Hellmold, H; Overvik, E; Strömstedt, M1
Kushida, H; Nagao, M; Ochiai, M; Sone, H; Sugimura, T; Wakabayashi, K1
Adamson, RH; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS; Thorgeirsson, UP1
Jägerstad, M; Johansson, M; Skog, K2
Boobis, AR; Davies, DS; Gooderham, NJ; Lynch, AM; Murray, S; Zhao, K1
Bohr, VA; Nouso, K; Schut, HA; Snyderwine, EG1
Guigoz, Y; Honegger, P; Juillerat, M; Schilter, B; Turesky, RJ1
Alexander, J; Ingebrigtsen, K; Klungsøyr, L; Vikse, R1
Alldrick, AJ; Brennan-Craddock, WE; Rowland, IR1
Enomoto, K; Kushida, H; Mori, M; Nagao, M; Sone, H; Sugimura, T; Takeichi, N; Tsuda, H; Wakabayashi, K1
Cui, L; Hasegawa, R; Hirose, M; Ito, N; Kato, T; Kobayashi, Y; Konishi, Y; Nakae, D; Shirai, T; Yaono, M1
Boobis, AR; Davies, DS; Gooderham, NJ; Rich, KJ; Zhao, K1
Fukutome, K; Sugimura, T; Tada, A; Takahashi, M; Takahashi, S; Totsuka, Y; Wakabayashi, K1
Hayatsu, H; Negishi, T; Shinoda, A; Sugiyama, C1
Boobis, AR; Davies, DS; de la Torre, R; Gooderham, NJ; Lynch, A; Murray, S; Segura, J2
Boobis, AR; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, S; Yadollahi-Farsani, M1
Adamson, RH; Sugimura, T; Thorgeirsson, UP1
Essigmann, JM; Morgenthaler, PM; Solomon, MS; Turesky, RJ1
Nagao, M; Sugimura, T; Totsuka, Y; Toyota, M; Ushijima, T; Wakabayashi, K1
Bhadresa, S; Boobis, AR; Bratt, C; Crosbie, SJ; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, BP; Murray, S; Rich, KJ; Yadollahi-Farsani, M; Zhao, K1
Boobis, AR; Gooderham, NJ; Lynch, AM; Murray, S1
Dacquel, EJ; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS1
Grivas, S1
Cunningham, PL; Dolbeare, FA; Felton, JS; Knize, MG1
Fay, LB; Turesky, RJ; Welti, DH1
Adamson, RH; Buonarati, MH; Snyderwine, EG; Turesky, RJ; Turteltaub, KW1
Adamson, RH; Davis, CD; Schut, HA; Snyderwine, EG; Thorgeirsson, SS1
Felton, JS; Frantz, C; McManus, M; Turteltaub, KW; Vogel, JS1
Akaike, T; Maeda, H; Sato, K1
Branting, C; Gustafsson, JA; Hellmold, H; Overvik, E1
Boobis, AR; Davies, DS; Edwards, RJ; Gooderham, NJ; Lynch, AM; Murray, BP; Murray, S; Rich, KJ; Zhao, K1
Gross, GA; Henderson, BE; Ji, H; Ross, RK; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ; Yu, MC1
Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R1
Adamson, RH; Dalgard, DW; Thorgeirsson, UP1
Inoue, R; Kakiuchi, H; Makino, H; Nagao, M; Sugimura, T; Ushijima, T1
Breneman, JW; Briner, JF; Director, A; Ramsey, MJ; Tucker, JD1
Heiniö, RL; Latva-Kala, KJ; Tikkanen, LM1
Sugimura, T1
Felton, JS; Hopmans, EC; Knize, MG; Salmon, CP1
Kristiansen, E; Meyer, O; Thorup, I1
Felton, JS; Knize, MG; Salmon, CP2
Kidd, LC; Sinha, R; Stillwell, WG; Tannenbaum, SR; Wishnok, JS1
Ohe, T1
Augustsson, K; Jägerstad, M; Skog, K; Steineck, G1
Akasaka, M; Matsusaka, N; Nishidate, E; Ohta, T; Saga, A; Sasaki, YF; Tsuda, S; Watanabe-Akanuma, M1
Jenq, SN; Lee, H; Yang, CC1
Futakuchi, M; Hirose, M; Ito, T; Miki, T; Orita, SI; Shirai, T; Tanaka, H1
Kaneko, T; Meguro, S; Terahara, M1
Dingley, KH; Fay, LB; Garner, RC; Leveson, SH; Richoz, J; Turesky, RJ; Turteltaub, KW; Welti, DH1
Grunnet, N; Knudsen, LE; Møller, P; Risom, L; Wallin, H1
Furukawa, F; Ikezaki, S; Kasahara, K; Kim, HC; Nishikawa, A; Takahashi, M; Tanakamaru, Z1
Barton, PT; Beamand, JA; Lake, BG; Price, RJ; Tredger, JM1
Oguri, A; Suda, M; Sugimura, T; Totsuka, Y; Wakabayashi, K1
Dingley, KH; Freeman, SP; Garner, RC; Nelson, DO; Turteltaub, KW1
Constable, A; Guengerich, FP; Markovic, J; Martin, MV; Richoz, J; Turesky, RJ; Varga, N1
Jägerstad, M; Skog, K; Vereskuns, G; Wesén, C1
Dingley, KH; Turteltaub, KW1
Cole, KJ; Grover, PL; Marquardt, H; Martin, FL; Pfau, W; Phillips, DH; Venitt, S1
Henderson, BE; Kidd, LC; Ross, RK; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Wishnok, JS; Yu, MC1
Kawanishi, S; Kobayashi, M; Murata, M1
Aryal, P; Guengerich, FP; Oda, Y; Shimada, T; Terashita, T; Yoshikawa, K1
Furukawa, F; Hirose, M; Kasahara, K; Miyauchi, M; Nakamura, H; Nishikawa, A; Takahashi, M1
Archer, C; Debiec-Rychter, M; Haas, GP; Jones, RF; King, CM; Morse, P; Schut, HA; Wang, CY1
Adamson, RH; Dalgard, DW; Ogawa, K; Ogiso, T; Shirai, T; Sugimura, T; Thorgeirsson, SS; Thorgeirsson, UP; Tsuda, H; Wakabayashi, K1
Fujita, K; Iwata, H; Kamataki, T; Kushida, H; Nohmi, T; Suzuki, A; Watanabe, M1
Akaike, T; Maeda, H; Sawa, T; Yubisui, T1
Sinha, R; Skipper, PL; Stillwell, WG; Tannenbaum, SR; Turesky, RJ1
Curtis, KD; Dingley, KH; Felton, JS; Garner, RC; Lang, NP; Malfatti, MA; Turesky, RJ; Turteltaub, KW1
Fukushima, S1
Alexander, DJ; Coxhead, JM; Cupid, BC; Dingley, KH; Garner, RC; Kutschera, W; Leveson, SH; Lightfoot, TJ; Mauthe, RJ; Priller, A; Rom, W; Russell, D; Steier, P; Turteltaub, KW1
Rothman, N; Sinha, R1
Degawa, M; Konno, Y; Moore, MA; Nakashita, K; Sekine, K; Takasuka, N; Tsuda, H; Uehara, N1
Ryu, DY; Snyderwine, EG; Thorgeirsson, SS; Weidner, V1
Sinha, R; Stillwell, WG; Tannenbaum, SR; Turesky, RJ1
Darroudi, F; Knasmüller, S; Kundi, M; Land, SJ; Parzefall, W; Sanyal, R; Schwab, CE; Wang, CY1
Amanuma, H; Amanuma, K; Aoki, Y; Takeda, H1
Anton-Culver, H; Butler, J; Delfino, RJ; Gim, JS; Liao, SY; Lin, HJ; Ma, HL; Sinha, R; Smith, C; West, J; White, E1
Furukawa, F; Hayashi, M; Itoh, T; Nishikawa, A; Sofuni, T; Suzuki, T; Takahashi, M; Xue, W1
Alavanja, MC; Brownson, RC; Curtin, J; Kulldorff, M; Sinha, R; Swanson, CA1
Futakuchi, M; Hirose, M; Ito, N; Lin, C; Shirai, T; Thamavit, W; Tiwawech, D1
Hirose, M; Kawabe, M; Kimoto, N; Lin, C; Sano, M; Shirai, T1
Bogen, KT; Enns, L; Hall, LC; Keating, GA; Murphy, G; Panteleakos, FN; Weinfeld, M; Wu, RW1
Fay, LB; Guengerich, FP; Guillouzo, A; Huynh-Ba, T; Kerriguy, N; Langouët, S; Markovic, J; Turesky, RJ; Welti, DH1
Broyde, S; Gauvin, J; Shapiro, R1
Amantana, A; Dashwood, RH; Orner, GA; Provost, C; Santana-Rios, G; Wu, SY1
Guengerich, FP; Huynh-Ba, T; Langouët, S; Parisod, V; Turesky, RJ1
Batty, SM; Boverhof, DR; Josephy, PD1
Boobis, AR; Bowey, EA; Edwards, AJ; Gooderham, NJ; Gray, S; Lake, BG; Murray, S; Springall, C; Williamson, G1
Furukawa, F; Mori, H; Mori, I; Nishikawa, A; Takahashi, M; Tanakamaru, Z1
Amanuma, K; Aoki, Y; Saito, H; Shigeoka, T; Tone, S1
Fay, LB; Guengerich, FP; Guillouzo, A; Kerriguy, N; Langouët, S; Turesky, RJ; Welti, DH1
Furukawa, F; Hirose, M; Koide, A; Miyauchi, M; Mori, Y; Nishikawa, A; Okazaki, K; Son, HY1
Fukushima, S; Iwai, S; Karim, R; Kitano, M; Min, W; Morimura, K; Seki, S; Sukata, T; Wanibuchi, H1
Paehler, A; Richoz, J; Soglia, J; Turesky, RJ; Vouros, P1
Jägerstad, M; Lundström, K; Olsson, V; Skog, K; Solyakov, A1
Alexander, J; Becher, G; Frandsen, H; Hegstad, S; Ingebrigtsen, K; Paulsen, JE; Reistad, R1
Asamoto, M; Hirose, M; Inaguma, S; Ogiso, T; Shirai, T; Suzuki, S; Takahashi, S1
Ambrosone, CB; Coles, B; Kadlubar, FF; Lang, NP; Luke Ratnasinghe, D; MacLeod, S; Nowell, S; Sinha, R; Stotts, C1
Guengerich, FP; Guillouzo, A; Langouët, S; Turesky, RJ1
Sinha, R1
Hanaoka, T; Kataoka, H; Kobayashi, M; Nishioka, S; Tsugane, S1
Arimoto-Kobayashi, S; Fujita, K; Kamataki, T; Negishi, T; Okamoto, K; Takahashi, E1
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Tatematsu, M; Totsuka, Y; Tsuda, H; Tsukamoto, T; Uehara, N; Wakabayashi, K; Wanibuchi, H; Wei, M1
Furukawa, F; Hirose, M; Kobayashi, Y; Koide, A; Mori, Y; Nishikawa, A1
Gray, JI; Shin, HS; Strasburg, GM1
Fukushima, S; Furukawa, F; Hirose, M; Imaida, K; Konishi, Y; Morimura, K; Nakae, D; Shirai, T; Takasuka, N; Tatematsu, M; Tsuda, H; Tsukamoto, T; Wanibuchi, H; Wei, M1
Persson, E; Sjöholm, I; Skog, K1
Horiguchi, M; Kanke, Y; Kanki, K; Masumura, K; Nishikawa, A; Nohmi, T; Umemura, T1
Fukushima, S; Nakae, D; Nishkawa, T; Ogawa, M; Otani, S; Totsuka, Y; Wakabayashi, K; Wanibuchi, H; Yano, Y1
Boyce, A; Doehmer, J; Gooderham, NJ1
Calvisi, DF; Conner, EA; Factor, VM; Ladu, S; Thorgeirsson, SS1
Hümmerich, J; Pfau, W; Zohm, C1
Allegro, G; Bertinetti, S; Bianchini, M; Davico, L; Fiorini, L; Hautefeuille, A; Malaveille, C; Sacerdote, C; Vineis, P1
Fukushima, S; Hoshi, M; Morimura, K; Okochi, E; Takaoka, K; Ushijima, T; Wanibuchi, H; Wei, M1
Freeman, JP; Gooderham, NJ; Holland, RD; Jones, RC; Lake, BG; Miller, DW; Schoenbachler, L; Taylor, J; Turesky, RJ1
Kohno, H; Sugie, S; Suzuki, R; Takahashi, M; Tanaka, T; Wakabayashi, K1
Borgen, E; Skog, K1
Badenhorst, AM; Coetsee, C; Walubo, A1
Fukushima, S; Ichihara, T; Morimura, K; Nakae, D; Totsuka, Y; Wanibuchi, H; Wei, M1
Hirose, M; Imazawa, T; Ishii, Y; Kanki, K; Kitamura, Y; Kuroiwa, Y; Nishikawa, A; Umemura, T1
Abramsson-Zetterberg, L; Durling, LJ1
Nyman, M; Persson, E; Sjöholm, I; Skog, K1
Arimoto-Kobayashi, S; Fujioka, R; Konuma, T; Nakandakari, N; Okamoto, K; Takata, J1
Gehring, T; Gooderham, NJ; Holland, RD; Lake, BG; Taylor, J; Turesky, RJ1
Bianchi, F; Careri, M; Corradini, C; Elviri, L; Mangia, A; Zagnoni, I1
Hsu, FF; Lakshmi, VM; Zenser, TV1
Chubachi, H; Imanishi, H; Inoue, Y; Komasa, Y; Mizoguchi, T; Nakano, M; Takekoshi, H1
Arimoto, S; Miyashita, Y; Negishi, T; Okamoto, K; Taira, K; Takahashi, E1
Cross, AJ; Hayes, RB; Kulldorff, M; Peters, U; Pinsky, PF; Rothman, N; Sinha, R; Weissfeld, JL1
Fukushima, S; Funae, Y; Kang, JS; Kinoshita, A; Kushida, M; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M1
Fukushima, S; Hayashi, S; Kinoshita, A; Morimura, K; Nishikawa, T; Nishikawa-Ogawa, M; Wanibuchi, H; Yano, Y1
Andriole, GL; Cross, AJ; Hayes, RB; Kirsh, VA; Peters, U; Reding, D; Sinha, R1
Fukushima, S; Hori, TA; Ichihara, T; Kang, JS; Morimura, K; Puatanachokchai, R; Wanibuchi, H; Wei, M1
Asamoto, M; Hokaiwado, N; Kuribayashi, M; Ogawa, K; Shirai, T; Suzuki, S1
Hsu, FF; Lakshmi, VM; Schut, HA; Zenser, TV1
Bennett, LM; Bennion, BJ; Cosman, M; Felton, JS; Knize, MG; Kulp, KS; Lightstone, FC; Montgomery, JL1
Doll, MA; Fretland, AJ; Hein, DW1
Doi, K; Fukushima, S; Karim, MR; Kinoshita, A; Morimura, K; Wanibuchi, H; Wei, M1
Fukushima, S; Kang, JS; Morimura, K; Totsuka, Y; Wanibuchi, H; Yoshimura, I1
Arimoto, S; Negishi, T; Okamoto, K; Takahashi, E1
Busquets, R; Galceran, MT; Puignou, L; Toribio, F1
Fukushima, S; Kang, JS; Kinoshita, A; Morimura, K; Murai, T; Wanibuchi, H1
Bendaly, J; Doll, MA; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; States, JC; Zhao, S1
Chen, F; Cheng, KW; Wang, M1
Peterson, S; Turesky, RJ; Wang, R; Yu, MC; Yuan, JM1
Slob, W1
Gibis, M1
Chen, F; Cheng, KW; Peng, X; Simon, JE; Wang, M; Wu, Q; Zheng, ZP1
Alavanja, MC; Cross, AJ; Hoppin, JA; Koutros, S; Ma, X; Sandler, DP; Sinha, R; Zheng, T1
Knasmüller, S; Koller, V; Sontag, G; Stidl, R1
Enokizono, J; Kusuhara, H; Ose, A; Schinkel, AH; Sugiyama, Y1
Ban, H; Hirata, A; Imai, T; Masegi, T; Nishigaki, R; Sakai, H; Takasu, S; Tatematsu, M; Totsuka, Y; Tsukamoto, T; Wakabayashi, K; Yanai, T1
Fukushima, S; Kang, JS; Mori, S; Morimura, K; Murai, T; Totsuka, Y; Wanibuchi, H1
Gibis, M; Jautz, U; Morlock, GE1
Futakuchi, M; Hirose, M; Kawabe, M; Shirai, T; Tamano, S1
Ferreira, IM; Melo, A; Petisca, C; Pinho, O; Viegas, O1
Bessette, EE; Goodenough, AK; Kozekov, ID; Langouët, S; Spivack, SD; Turesky, RJ; Yasa, I1
Bagnardi, V; Bertazzi, PA; Caporaso, NE; Consonni, D; Cross, AJ; Lam, TK; Landi, MT; Randi, G; Sinha, R; Subar, AF1
Libudzisz, Z; Nowak, A1
Bendaly, J; Hein, DW; Metry, KJ; Neale, JR; Pierce, WM; Smith, NB1
Busquets, R; Frandsen, H; Galceran, MT; Jönsson, JA; Puignou, L; Skog, K1
Doll, MA; Hein, DW; Howarth, AL; McGregor, WG; Metry, KJ; Neale, JR; Pierce, WM; States, JC1
Gooderham, NJ; Gu, D; Kadlubar, FF; Lake, BG; Lemaster, D; McNaughton, L; Turesky, RJ1
Cross, AJ; Ferrucci, LM; Graubard, BI; Hollenbeck, AR; Park, Y; Risch, A; Schatzkin, A; Sinha, R; Ward, MH1
Aninat, C; Anthérieu, S; Dumont, J; Guguen-Guillouzo, C; Guillouzo, A; Jossé, R; Lambert, C; Le Hegarat, L; Robin, MA1
Cho, E; Giovannucci, E; Holmes, MD; Sinha, R; Willett, W; Wu, K1
Asamoto, M; Doi, Y; Naiki-Ito, A; Shirai, T; Suzuki, S; Takahashi, S; Takeshita, K1
Puangsombat, K; Smith, JS1
Haza, AI; Morales, P1
Gonzalo-Lumbreras, R; León-González, ME; Pérez-Arribas, LV; Polo-Díez, LM; Rosales-Conrado, N1
Anthérieu, S; Dumont, J; Guillouzo, A; Jossé, R; Lambert, C; Laurent, V; Loyer, P; Robin, MA1
Inoue, T; Ishii, Y; Kodama, Y; Mitsumori, K; Nishikawa, A; Nohmi, T; Okamura, T; Suzuki, Y; Tasaki, M; Umemura, T2
Abnet, CC; Cross, AJ; Freedman, ND; Hollenbeck, AR; Ren, J; Schatzkin, A; Sinha, R; Ward, MH1
Caberto, C; Chanock, S; Decker, R; Le Marchand, L; Saltzman, B; Vogt, TM; Wang, H; Wilkens, LR; Yamamoto, JF; Yokochi, L1
Gu, D; Kadlubar, FF; Raymundo, MM; Turesky, RJ1
Deming, SL; Fair, AM; Fu, Z; Kelley, M; Shrubsole, MJ; Shu, XO; Wujcik, DM; Zheng, W1
Arimoto-Kobayashi, S; Hatano, T; Ishida, R; Kamiya, T; Okamoto, G; Yuhara, Y; Zhang, X1
Ambalam, P; Dave, JM; Nair, BM; Vyas, BR1
Jirapakkul, W; Puangsombat, K; Smith, JS1
Bessette, EE; Dunbar, D; Liberman, RG; Skipper, PL; Turesky, RJ1
Peng, Z; Shao, B; Wan, K; Wu, G; Yang, H; Yao, Y1
Gadgil, P; Houser, TA; Hunt, MC; Puangsombat, K; Smith, JS1
Ferreira, IM; Filipič, M; Novak, M; Pezdric, M; Pinho, O; Viegas, O; Zegura, B1
Feinstein, Y; Friedman, M; Havens, CM; Ravishankar, S; Rounds, L1
Liao, GZ; Wang, GY; Xu, XL; Zhang, YJ; Zhou, GH1
Aschebrook-Kilfoy, B; Chiu, BC; Kolar, C; Lawson, TA; Ollberding, NJ; Smith, SM; Weisenburger, DD1
Hayashi, H; Hayashi, M; Mitsumori, K; Morita, R; Nakamura, D; Shibutani, M; Suzuki, K; Taniai, E; Wakita, A1
Ding, Z; Guo, D; Li, F; Su, M; Wang, M; Yao, J1
Fujii-Kuriyama, Y; Goto, M; Iijma, K; Ishizaka, Y; Kano, S; Matsunaga, A; Nakagama, H; Ochiai, M; Okamura, T; Okudaira, N; Tamura, M1
Cross, AJ; Harper, G; Hartman, TJ; Laio, J; Lazarus, P; Lesko, SM; Miller, PE; Muscat, JE; Sinha, R; Zhu, J1
Gibis, M; Weiss, J2
Blasiak, J; Chojnacki, C; Chojnacki, J; Czubatka, A; Klupinska, G; Poplawski, T1
Ishii, Y; Jin, M; Kijima, A; Kodama, Y; Kuroda, K; Matsushita, K; Takasu, S; Umemura, T1
Filipič, M; Pezdirc, M; Žegura, B1
Mei, J; Wang, S; Yu, C; Zhang, Y1
Szterk, A1
Helmus, DS; Li, L; Thompson, CL; Tucker, TC; Zelenskiy, S1
Aalhus, JL; Dugan, ME; Juárez, M; Ruan, ED; Thacker, R; Yang, X1
Houser, TA; Hunt, MC; Smith, JS; Vangnai, K1
Cooper, KM; Cuskelly, G; Jankhaikhot, N1
Gibis, M; Kruwinnus, M; Weiss, J1
Chen, J; Gao, Y; He, Z; Qin, F; Tao, G; Zeng, M; Zhang, S; Zheng, Z1
Dennis, C; Karim, F; Smith, JS1
Artioli, GG; Carpentier, A; Dantas, WS; Dörr, FA; Fernandes, AL; Gualano, B; Murai, IH; Pereira, RT; Pinto, E; Poortmans, JR; Roschel, H; Santinho, MA; Seguro, AC; Solis, MY1
Fukushima, S; Gi, M; Kakehashi, A; Matsumoto, M; Wanibuchi, H1
Daniel, CR; Karam, JA; Matin, SF; Melkonian, SC; Tannir, NM; Wood, CG; Wu, X; Ye, Y1
Anderson, KE; Jensen, EH; Kuhn, EA; Malfatti, MA; Strayer, L; Turteltaub, KW; Vickers, SM1
Baffet, G; Bellamri, M; Langouët, S; Le Hegarat, L; Turesky, RJ; Vernhet, L1
Guo, J; Krishna, S; Murugan, P; Tejpaul, R; Turesky, RJ; Villalta, PW; Weight, CJ; Xiao, S; Yun, BH1
Audebert, M; Chevereau, M; Cravedi, JP; Glatt, H; Zalko, D1
Empl, MT; Engels, C; Fekry, MI; Lacroix, C; Schneider, M; Schwab, C; Steinberg, P; Sturla, SJ; Zhang, J1
Han, Z; Shao, Z; Wang, S; Zhang, J; Zhang, Y1
Agim, ZS; Cannon, JR; Cruz-Hernandez, A; McCabe, GP; Montenegro, PC; Rochet, JC1
Castaño, PR; Linseisen, J; Martínez Góngora, V; Matthes, KL; Rohrmann, S1
Beer, F; Bunzel, D; Bunzel, M; Franz, CMAP; Huch, M; Kulling, SE; Urbat, F1
Guo, R; Huang, H; Liu, R; Oyang, Q; Rong, J; Song, D; Wang, B; Xiao, X; Zheng, P1
Breves, G; Empl, MT; Schneider, M; Schröder, B; Stadnicka-Michalak, J; Steinberg, P; Sturla, SJ; Zhang, J1
Bao, X; Huang, Y; Lai, K; Miao, J1
Angénieux, M; Blinet, P; Chaloin, L; Chevolleau, S; Debrauwer, L; Engel, E; Mercier, F; Meurillon, M1
Hidalgo, FJ; Lavado-Tena, CM; Zamora, R1
Chen, J; He, Z; Li, Y; Qin, F; Quan, W; Wang, J; Wang, Z; Zeng, M1

Reviews

21 review(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines

ArticleYear
Absorption and disposition of MeIQx in man: lessons for human dosimetry.
    Progress in clinical and biological research, 1991, Volume: 372

    Topics: Absorption; Animals; Biotransformation; Carcinogens; Dose-Response Relationship, Drug; Hemoglobins; Humans; Mutagens; Quinoxalines

1991
MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline).
    IARC monographs on the evaluation of carcinogenic risks to humans, 1993, Volume: 56

    Topics: Animals; Carcinogens; Cooking; Fishes; Food; Food Analysis; Humans; Meat; Neoplasms; Quinoxalines

1993
Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1996, Volume: 18

    Topics: Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Food Handling; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Meat; Mutagens; Oxidoreductases; Quinoxalines

1996
Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1996, Volume: 18

    Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Food Handling; Gene Expression Regulation, Enzymologic; Humans; Hydroxylation; Imidazoles; Liver; Meat Products; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Species Specificity

1996
Extrapolation of heterocyclic amine carcinogenesis data from rodents and nonhuman primates to humans.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1996, Volume: 18

    Topics: Amines; Animals; Biotransformation; Carcinogens; Diet; Food Handling; Heterocyclic Compounds; Humans; Imidazoles; Meat; Mice; Mutagens; Neoplasms; Primates; Quinoxalines; Rats; Risk Assessment; Species Specificity; Structure-Activity Relationship

1996
Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
    Environmental health perspectives, 1996, Volume: 104 Suppl 3

    Topics: Amines; Animals; Carcinogens, Environmental; DNA Adducts; Environmental Exposure; Food Contamination; Heterocyclic Compounds; Humans; Imidazoles; Mutagens; Mutation; Neoplasms; Quinoxalines

1996
Heterocyclic amines: evaluation of their role in diet associated human cancer.
    British journal of clinical pharmacology, 1996, Volume: 42, Issue:1

    Topics: Animals; Biological Availability; Carcinogens; Diet; Humans; Imidazoles; Meat; Mutagens; Neoplasms; Quinoxalines

1996
Exposure to and activation of dietary heterocyclic amines in humans.
    Critical reviews in oncology/hematology, 1995, Volume: 21, Issue:1-3

    Topics: Animals; Biological Availability; Biotransformation; Carcinogens; Colorectal Neoplasms; Cooking; Cytochrome P-450 CYP1A2; Diet; DNA Adducts; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Liver; Meat; Mutagenicity Tests; Mutagens; Proteins; Quinolines; Quinoxalines; Rats; Risk Assessment

1995
Synthetic routes to the food carcinogen 2 amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx) and related compounds.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Cooking; Corn Oil; Dietary Fats; Fishes; Free Radicals; Hot Temperature; Humans; Maillard Reaction; Meat; Molecular Structure; Mutagens; Olive Oil; Plant Oils; Quinoxalines; Structure-Activity Relationship

1995
Factors affecting the formation and yield of heterocyclic amines.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Carcinogens; Cooking; Heterocyclic Compounds; Hot Temperature; Humans; Maillard Reaction; Meat; Mutagens; Quinoxalines

1995
Mutagenic activity and heterocyclic amine content of the human diet.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Amines; Animals; Cattle; Cooking; Fishes; Food Analysis; Heterocyclic Compounds; Hot Temperature; Humans; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium

1995
Metabolism of heterocyclic aromatic amines and strategies of human biomonitoring.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Biotransformation; Blood Proteins; Carcinogens; Cooking; Cytochrome P-450 Enzyme System; Environmental Monitoring; Fishes; Hot Temperature; Humans; Inactivation, Metabolic; Intestinal Absorption; Meat; Mutagens; Primates; Quinolines; Quinoxalines; Rodentia

1995
Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; DNA Adducts; Humans; Imidazoles; Mass Spectrometry; Mutagens; Neoplasms; Phosphorus Radioisotopes; Quinoxalines; Radioisotope Dilution Technique; Rodentia

1995
Superoxide radical generation from heterocyclic amines.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Amines; Animals; Carcinogens; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Heterocyclic Compounds; Humans; Kinetics; Microsomes, Liver; Mutagenicity Tests; Mutagens; NADH Dehydrogenase; NADP; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Spin Labels; Superoxides

1995
Activation and effects of the food-derived heterocyclic amines in extrahepatic tissues.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Amines; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cell Line; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; DNA Damage; Food; Heterocyclic Compounds; Hot Temperature; Humans; Hypoxanthine Phosphoribosyltransferase; Imidazoles; Lung; Meat; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Quinoxalines; Rats

1995
Enzymatic studies of the activation of heterocyclic food mutagens in man.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Biotransformation; Callithrix; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Macaca fascicularis; Meat; Microsomes, Liver; Mutagens; Quinoxalines; Rabbits; Substrate Specificity

1995
Systemic exposure to dietary heterocyclic amines in man.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Biotransformation; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Diet; Environmental Exposure; Enzyme Inhibitors; Hot Temperature; Humans; Imidazoles; Meat; Metabolic Clearance Rate; Mutagens; Quinoxalines; Theophylline

1995
Biomarkers of exposure to heterocyclic amines: approaches to improve the exposure assessment.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:8

    Topics: Animals; Biomarkers; Carcinogens; Dose-Response Relationship, Drug; Environmental Exposure; Environmental Monitoring; Hair; Heterocyclic Compounds; Humans; Imidazoles; Mice; Quinoxalines

2002
An epidemiologic approach to studying heterocyclic amines.
    Mutation research, 2002, Sep-30, Volume: 506-507

    Topics: Amines; Animals; Carcinogens; Cooking; Diet; Dietary Proteins; Epidemiologic Studies; Heterocyclic Compounds; Humans; Imidazoles; Meat Products; Neoplasms; Quinoxalines; Risk Factors; Surveys and Questionnaires

2002
Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.
    Mutagenesis, 2016, Volume: 31, Issue:3

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Guanosine; Humans; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

2016
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019, Volume: 28, Issue:1

    Topics: Adenoma; Adult; Aged; Amines; Benzo(a)pyrene; Colorectal Neoplasms; Diet; Female; Heterocyclic Compounds; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Odds Ratio; Quinoxalines; Red Meat

2019

Trials

5 trial(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines

ArticleYear
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.
    Cancer research, 1994, Jan-01, Volume: 54, Issue:1

    Topics: Adult; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Imidazoles; Male; Oxidoreductases; Phenacetin; Quinoxalines; Theophylline

1994
Metabolism of the food-borne mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans.
    Chemical research in toxicology, 1998, Volume: 11, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Female; Food Contamination; Humans; Male; Microsomes, Liver; Middle Aged; Mutagens; Quinoxalines; Reference Standards; Smoking

1998
Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity.
    Mutation research, 2004, Jul-11, Volume: 561, Issue:1-2

    Topics: Adult; Animals; Antimutagenic Agents; Chlorodiphenyl (54% Chlorine); Diet; DNA Adducts; Flavonoids; Humans; Male; Microsomes, Liver; Mutagenicity Tests; Phenols; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Smoking; Spectrophotometry

2004
A prospective study of meat and meat mutagens and prostate cancer risk.
    Cancer research, 2005, Dec-15, Volume: 65, Issue:24

    Topics: Aged; Benzo(a)pyrene; Cooking; Diet; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Prospective Studies; Prostatic Neoplasms; Quinoxalines; Risk Factors; Surveys and Questionnaires

2005
Can creatine supplementation form carcinogenic heterocyclic amines in humans?
    The Journal of physiology, 2015, Sep-01, Volume: 593, Issue:17

    Topics: Adult; Amines; Carcinogens; Creatine; Cross-Over Studies; Diet; Female; Furans; Humans; Imidazoles; Male; Quinoxalines; Single-Blind Method

2015

Other Studies

327 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and quinoxalines

ArticleYear
Effect of dietary fiber on the disposition and excretion of a food carcinogen (2-14C-labeled MeIQx) in rats.
    Nutrition and cancer, 1992, Volume: 17, Issue:2

    Topics: Animals; Carbon Radioisotopes; Carcinogens; Dietary Fiber; DNA; Gastrointestinal Transit; In Vitro Techniques; Male; Mutagens; Pectins; Poaceae; Quinoxalines; Rats; Rats, Inbred Strains; Solubility

1992
Reversible binding of the cooked food mutagen MeIQx to lignin-enriched preparations from wheat bran.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1992, Volume: 30, Issue:3

    Topics: Dietary Fiber; Lignin; Microscopy, Electron, Scanning; Mutagenicity Tests; Mutagens; Quinoxalines; Triticum

1992
Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:11

    Topics: Amines; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; DNA; Electron Spin Resonance Spectroscopy; Heterocyclic Compounds; Hydroxylation; Kinetics; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; NADP; NADPH-Ferrihemoprotein Reductase; Pentetic Acid; Quinolines; Quinoxalines; Reactive Oxygen Species; Superoxides

1992
Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed.
    Mutation research, 1992, Volume: 280, Issue:2

    Topics: Dose-Response Relationship, Drug; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Reproducibility of Results; Salmonella typhimurium

1992
Effect of hepatic cytochrome P-450 inducing agents on mutagen activity in the host-mediated assay.
    Mutation research, 1992, Volume: 268, Issue:2

    Topics: Aflatoxins; Analysis of Variance; Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Mice; Mice, Inbred BALB C; Mutagenesis; Mutagenicity Tests; Mutagens; Phenobarbital; Quinoxalines; Salmonella typhimurium

1992
Inhibition of the metabolism of mutagens occurring in food by arachidonic acid.
    Mutation research, 1992, Volume: 269, Issue:2

    Topics: Aflatoxin B1; Animals; Antimutagenic Agents; Arachidonic Acid; Biotransformation; DNA Repair; Food; Imidazoles; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium

1992
Electron impact and fast atom bombardment mass spectrometric analysis of the food-borne carcinogens 2-amino-3-methylimidazo [4,5-f] quinoline, 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline and their metabolites.
    Biological mass spectrometry, 1992, Volume: 21, Issue:9

    Topics: Carcinogens; Food Analysis; Glucuronates; Quinolines; Quinoxalines; Spectrometry, Mass, Fast Atom Bombardment; Sulfates

1992
Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.
    Cancer research, 1992, Nov-15, Volume: 52, Issue:22

    Topics: Adult; Animals; Carcinogens; Cattle; Cooking; Gas Chromatography-Mass Spectrometry; Genetic Variation; Humans; Imidazoles; Individuality; Male; Meat; Mutagens; Quinoxalines

1992
N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver.
    Carcinogenesis, 1992, Volume: 13, Issue:12

    Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Humans; Hydroxylation; Mass Spectrometry; Microsomes, Liver; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Theophylline

1992
Tissue distribution of the food mutagen MeIQx in control and BNF-treated mice.
    Pharmacology & toxicology, 1992, Volume: 71, Issue:6

    Topics: Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; Drug Interactions; Female; Injections, Intravenous; Mice; Mutagens; Quinoxalines; Tissue Distribution

1992
Metabolic activation and genotoxicity of heterocyclic arylamines.
    Cancer research, 1992, Apr-01, Volume: 52, Issue:7 Suppl

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; DNA; Heterocyclic Compounds; Imidazoles; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Polychlorinated Dibenzodioxins; Quinolines; Quinoxalines; Salmonella

1992
Chemical analysis, prevention, and low-level dosimetry of heterocyclic amines from cooked food.
    Cancer research, 1992, Apr-01, Volume: 52, Issue:7 Suppl

    Topics: DNA; Food Analysis; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Meat; Mutagenicity Tests; Quinolines; Quinoxalines

1992
Direct O-acetylation of N-hydroxy arylamines by acetylsalicylic acid to form carcinogen-DNA adducts.
    Carcinogenesis, 1992, Volume: 13, Issue:4

    Topics: Acetylation; Aminobiphenyl Compounds; Aspirin; Carcinogens; DNA; Fluorenes; Imidazoles; Quinolines; Quinoxalines

1992
Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes.
    Pharmacology & toxicology, 1992, Volume: 70, Issue:3

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; DNA; Male; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains

1992
Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in two strains of male rats.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: Animals; Autoradiography; Kidney; Liver; Male; Mutagens; Quinoxalines; Rats; Skin; Species Specificity; Tissue Distribution

1992
Induction of preneoplastic lesions by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the livers of rats treated with carbon tetrachloride.
    Carcinogenesis, 1992, Volume: 13, Issue:5

    Topics: Animals; Carbon Tetrachloride; DNA; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1992
Comparative carcinogenicity of 4-aminobiphenyl and the food pyrolysates, Glu-P-1, IQ, PhIP, and MeIQx in the neonatal B6C3F1 male mouse.
    Cancer letters, 1992, Mar-15, Volume: 62, Issue:3

    Topics: Aminobiphenyl Compounds; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Imidazoles; Liver Neoplasms, Experimental; Male; Mice; Mutagens; Quinolines; Quinoxalines

1992
Distribution and elimination of [2-14C]amino-3,8-dimethylimidazo [4, 5-f] quinoxaline in mice. Analysis by whole animal autoradiography.
    Human & experimental toxicology, 1991, Volume: 10, Issue:5

    Topics: Animals; Autoradiography; Carbon Radioisotopes; Male; Mice; Mice, Inbred Strains; Quinoxalines; Tissue Distribution

1991
Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats.
    Carcinogenesis, 1990, Volume: 11, Issue:12

    Topics: Animals; Binding, Competitive; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation; Imidazoles; Intestines; Kidney; Liver; Lung; Male; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA

1990
An experimental approach to identifying the genotoxic risk from cooked meat mutagens.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1991, Volume: 29, Issue:6

    Topics: Administration, Oral; Animals; Cattle; Cell Line; Chromosome Aberrations; Cooking; Cricetinae; Cricetulus; DNA; Female; Food Contamination; Humans; Male; Meat; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Risk Factors; Tissue Distribution

1991
An experimental approach to identifying the genotoxic risk by cooked meat mutagens.
    Advances in experimental medicine and biology, 1991, Volume: 289

    Topics: Animals; Bone Marrow; Cell Line; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymphocytes; Male; Meat Products; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Protein Binding; Quinolines; Quinoxalines; Salmonella typhimurium; Tissue Distribution

1991
Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation.
    Carcinogenesis, 1991, Volume: 12, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carbolines; Diet; Female; Humans; Imidazoles; Male; Middle Aged; Parenteral Nutrition, Total; Quinoxalines

1991
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: Acetylation; Amines; Animals; Biotransformation; Carcinogens; Colon; Cytochrome P-450 Enzyme System; Cytosol; Heterocyclic Compounds; Humans; Imidazoles; Liver; Microsomes, Liver; Mutagens; Oxidation-Reduction; Quinolines; Quinoxalines; Rats

1991
The effect of dose and cytochrome P450 induction on the metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) in the rat.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: 1-Naphthylamine; Animals; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Feces; Glucuronates; Glucuronosyltransferase; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Mutagens; Nitrophenols; Oxidation-Reduction; Quinoxalines; Rats; Rats, Inbred Strains; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet

1991
The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines.
    Mutation research, 1991, Volume: 256, Issue:1

    Topics: Administration, Oral; Aging; Amines; Animals; Carbolines; Diet; DNA; DNA Damage; Heart; Imidazoles; Kinetics; Liver; Male; Myocardium; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1991
DNA dosimetry following carcinogen exposure using accelerator mass spectrometry and 32P-postlabeling.
    Progress in clinical and biological research, 1991, Volume: 372

    Topics: Animals; Binding Sites; Carcinogens; DNA; DNA Damage; Humans; Imidazoles; Mass Spectrometry; Mice; Phosphorus Radioisotopes; Quinoxalines

1991
Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines.
    Molecular carcinogenesis, 1991, Volume: 4, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Codon; Ear Neoplasms; Ear, External; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Sebaceous Gland Neoplasms

1991
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: Animals; Body Weight; Carbolines; Carcinogens; Drug Synergism; Enzyme Induction; Glutathione Transferase; Imidazoles; Immunohistochemistry; Liver; Liver Neoplasms; Male; Organ Size; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1991
The measurement of MeIQx adducts with mouse haemoglobin in vitro and in vivo: implications for human dosimetry.
    Carcinogenesis, 1991, Volume: 12, Issue:6

    Topics: Animals; Carbon Radioisotopes; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Hemoglobins; Humans; Hydrolysis; In Vitro Techniques; Mice; Microsomes; Mutagens; Quinolines; Quinoxalines

1991
DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.
    Japanese journal of cancer research : Gann, 1990, Volume: 81, Issue:5

    Topics: Animals; DNA; Dose-Response Relationship, Drug; Drug Resistance; Glutathione Transferase; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344; Time Factors

1990
Metabolic processing and carcinogenicity of heterocyclic amines in nonhuman primates.
    Princess Takamatsu symposia, 1990, Volume: 21

    Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; Dose-Response Relationship, Immunologic; Imidazoles; Liver Neoplasms, Experimental; Macaca fascicularis; Mutagens; Quinolines; Quinoxalines

1990
Human neutrophils can activate the food-derived carcinogen MeIQx.
    Biochemical Society transactions, 1990, Volume: 18, Issue:4

    Topics: Biotransformation; Carcinogens; DNA; Food Contamination; Humans; In Vitro Techniques; Mutagens; Neutrophils; Quinoxalines; Superoxides

1990
Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx.
    Progress in clinical and biological research, 1990, Volume: 340B

    Topics: Animals; Biotransformation; Cattle; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Guinea Pigs; Hot Temperature; Humans; Intestinal Absorption; Isoenzymes; Male; Meat; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinoxalines; Rabbits; Salmonella typhimurium; Species Specificity; Theophylline

1990
Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer research, 1990, Dec-15, Volume: 50, Issue:24

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Chromosome Mapping; Dimethylhydrazines; Dimethylnitrosamine; Epithelium; Female; Intestine, Small; Male; Mice; Mice, Inbred Strains; Mutagenesis; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium

1990
Inflammatory cells from the rat pleural cavity can activate the food-derived carcinogen MeIQx.
    Biochemical Society transactions, 1990, Volume: 18, Issue:4

    Topics: Animals; Biotransformation; Carcinogens; Food Contamination; In Vitro Techniques; Inflammation; Mutagens; Phagocytes; Pleura; Quinoxalines; Rats

1990
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Enzyme Induction; Galactosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Phenobarbital; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1990
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
    Cancer research, 1990, Jun-01, Volume: 50, Issue:11

    Topics: 2-Acetylaminofluorene; Adolescent; Adult; Aged; Benzo(a)pyrene; Cell Line; Child; Cytochrome P-450 Enzyme System; Food Contamination; Gene Expression; Humans; Hydroxylation; Imidazoles; Microsomes, Liver; Middle Aged; Quinolines; Quinoxalines

1990
Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:14

    Topics: Animals; Carbon Radioisotopes; Carcinogens; Dioxins; DNA; Dose-Response Relationship, Drug; Kinetics; Liver; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Phosphorus Radioisotopes; Polychlorinated Dibenzodioxins; Quinoxalines

1990
Effects of monosaccharides and disaccharides on the formation of food mutagens in model systems.
    Mutation research, 1990, Volume: 230, Issue:2

    Topics: Chromatography, High Pressure Liquid; Creatine; Creatinine; Disaccharides; Ethylene Glycols; Food; Glycine; Hot Temperature; Maillard Reaction; Monosaccharides; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella; Temperature

1990
Mechanism of the in vitro antimutagenic action of retinol.
    Mutagenesis, 1990, Volume: 5, Issue:3

    Topics: Animals; Biotransformation; Computer Simulation; In Vitro Techniques; Male; Models, Biological; Mutagenicity Tests; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Submitochondrial Particles; Vitamin A

1990
Role of metabolism on the DNA binding of MeIQx in mice and bacteria.
    Carcinogenesis, 1990, Volume: 11, Issue:1

    Topics: Animals; DNA; DNA, Bacterial; Liver; Male; Mice; Mice, Inbred C57BL; Mutagens; Phosphorus Radioisotopes; Quinoxalines; Radioisotope Dilution Technique; Salmonella typhimurium

1990
Nucleic acid binding and mutagenicity of active metabolites of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Mutation research, 1989, Volume: 210, Issue:1

    Topics: Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; DNA; DNA Damage; In Vitro Techniques; Mass Spectrometry; Microsomes, Liver; Mutation; Nucleic Acid Conformation; Quinoxalines; RNA; Structure-Activity Relationship; Ultraviolet Rays

1989
The food-mutagens 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) initiate enzyme-altered hepatic foci in the resistant hepatocyte model.
    Carcinogenesis, 1989, Volume: 10, Issue:9

    Topics: Animals; Diethylnitrosamine; Drug Resistance; gamma-Glutamyltransferase; Imidazoles; Liver; Male; Meat; Mutagens; Quinoxalines; Rats; Rats, Inbred Strains

1989
Purification of the food-borne carcinogens 2-amino-3-methylimidazo [4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in heated meat products by immunoaffinity chromatography.
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Cattle; Chromatography, Affinity; Chromatography, High Pressure Liquid; Hot Temperature; Immunologic Techniques; Meat; Mutagens; Quinolines; Quinoxalines; Radioimmunoassay

1989
Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Animals; Bile; Biotransformation; Carbon Radioisotopes; Feces; Female; Male; Mutagenicity Tests; Mutagens; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sex Factors; Tissue Distribution

1989
Covalent binding of [2-14C]2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) to mouse DNA in vivo.
    Carcinogenesis, 1989, Volume: 10, Issue:8

    Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; DNA; Female; Kinetics; Mice; Mice, Inbred BALB C; Mutagens; Quinoxalines; Radioisotope Dilution Technique; Tissue Distribution

1989
Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal.
    Carcinogenesis, 1989, Volume: 10, Issue:4

    Topics: Gas Chromatography-Mass Spectrometry; Humans; Male; Meat; Mutagens; Quinoxalines

1989
Significant increase of IQ-type heterocyclic amines, dietary carcinogens in the plasma of patients with uremia just before induction of hemodialysis treatment.
    Nephron, 1989, Volume: 52, Issue:1

    Topics: Adult; Carcinogens; Chromatography, High Pressure Liquid; Diet; Female; Humans; Male; Middle Aged; Mutagens; Quinolines; Quinoxalines; Renal Dialysis; Uremia

1989
Metabolism of the food carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in isolated rat liver cells.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Animals; Aroclors; Biotransformation; Carcinogens; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Food; Glucuronates; Glutathione; Liver; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred Strains

1989
Effect of heterocyclic amines and beef extract on chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes.
    Carcinogenesis, 1989, Volume: 10, Issue:3

    Topics: Animals; Cattle; Cells, Cultured; Chromosome Aberrations; DNA Damage; Dose-Response Relationship, Drug; Humans; Lymphocytes; Meat; Mutagens; Quinolines; Quinoxalines; Sister Chromatid Exchange

1989
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
    Chemico-biological interactions, 1988, Volume: 68, Issue:3-4

    Topics: Animals; Biotransformation; Carbolines; Carcinogens; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Insulin; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Mutagenicity Tests; Mutagens; Niacinamide; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains

1988
In vitro reaction of hydroxyamino derivatives of MeIQx, Glu-P-1 and Trp-P-1 with DNA: 32P-postlabelling analysis of DNA adducts formed in vivo by the parent amines and in vitro by their hydroxyamino derivatives.
    Mutagenesis, 1988, Volume: 3, Issue:6

    Topics: Animals; Binding Sites; Carbolines; Carcinogens; DNA; Hydroxylamines; Imidazoles; In Vitro Techniques; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344

1988
The presence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in smoked dry bonito (katsuobushi).
    Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:2

    Topics: Chromatography, High Pressure Liquid; Fish Products; Food Handling; Mutagens; Quinoxalines; Spectrophotometry, Ultraviolet

1986
Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450.
    Carcinogenesis, 1988, Volume: 9, Issue:1

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Quinoxalines; Rats; Rats, Inbred Strains; Subcellular Fractions

1988
Analysis of mutagenic heterocyclic amines in cooked beef products by high-performance liquid chromatography in combination with mass spectrometry.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1988, Volume: 26, Issue:6

    Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Hot Temperature; Mass Spectrometry; Meat; Mutagenicity Tests; Quinolines; Quinoxalines

1988
Distribution of radiolabelled [2-14C]IQ and MeIQx in the mouse.
    Toxicology letters, 1988, Volume: 44, Issue:1-2

    Topics: Administration, Oral; Animals; Carbon Radioisotopes; Carcinogens; Chromatography, Thin Layer; Female; Gastrointestinal Contents; Intestinal Absorption; Mice; Mice, Inbred BALB C; Quinolines; Quinoxalines; Tissue Distribution

1988
A model system for studying covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein.
    IARC scientific publications, 1988, Issue:89

    Topics: Animals; Biotransformation; Carcinogens; DNA; Food Analysis; In Vitro Techniques; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats

1988
An assay for 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline in fried beef using capillary column gas chromatography electron capture negative ion chemical ionization mass spectrometry.
    Biomedical & environmental mass spectrometry, 1988, Volume: 16, Issue:1-12

    Topics: Animals; Carbon Isotopes; Cattle; Cooking; Gas Chromatography-Mass Spectrometry; Meat; Mutagens; Nitrogen Isotopes; Quinoxalines

1988
Formation of mutagens, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), in heated fish meats.
    Mutation research, 1987, Volume: 179, Issue:1

    Topics: Animals; Cooking; Creatine; Desiccation; Fishes; Hot Temperature; Mutagenicity Tests; Quinoxalines; Rats; Salmonella typhimurium; Species Specificity

1987
The hepatic conversion of some heterocyclic amines to bacterial mutagens is modified by dietary fat and cholesterol.
    Mutagenesis, 1987, Volume: 2, Issue:3

    Topics: Animals; Biotransformation; Cattle; Cholesterol, Dietary; Dietary Fats; Hot Temperature; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium

1987
Effect of tryptamine on the mutagenic activity of 2-amino-3-methylimidazo(4,5-f) quinoline (IQ) and related azaarenes in the Ames test.
    Mutagenesis, 1987, Volume: 2, Issue:1

    Topics: Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytosol; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity; Tryptamines

1987
Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Carcinogenesis, 1988, Volume: 9, Issue:1

    Topics: Animals; Clitoris; Female; Food; Genital Neoplasms, Female; Hot Temperature; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms

1988
Measurement of MeIQx and DiMeIQx in fried beef by capillary column gas chromatography electron capture negative ion chemical ionisation mass spectrometry.
    Carcinogenesis, 1988, Volume: 9, Issue:2

    Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cooking; Gas Chromatography-Mass Spectrometry; Meat; Mutagens; Quinoxalines

1988
Metabolism of the food-borne mutagen/carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat: assessment of biliary metabolites for genotoxicity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1988, Volume: 26, Issue:2

    Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Male; Mutagenicity Tests; Quinoxalines; Rats; Rats, Inbred Strains

1988
Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat.
    Carcinogenesis, 1988, Volume: 9, Issue:6

    Topics: Animals; Bile; Carbon Radioisotopes; Carcinogens; Feces; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Male; Quinoxalines; Rats; Rats, Inbred Strains

1988
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.
    Mutation research, 1988, Volume: 201, Issue:1

    Topics: China; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cooking; Diet; Food Analysis; Heterocyclic Compounds; Imidazoles; Mutagenicity Tests; Mutagens; Mutation; Neoplasms; Quinolines; Quinoxalines

1988
MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline).
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 40

    Topics: Animals; Chemical Phenomena; Chemistry; Female; Male; Meat Products; Mice; Mutagenicity Tests; Quinoxalines; Rats

1986
Mutagenic metabolites in urine and feces of rats fed with 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, a carcinogenic mutagen present in cooked meat.
    Cancer research, 1987, Feb-01, Volume: 47, Issue:3

    Topics: Animals; Biotransformation; Carcinogens; Feces; Hot Temperature; Magnetic Resonance Spectroscopy; Male; Meat; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium

1987
Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods.
    Carcinogenesis, 1987, Volume: 8, Issue:5

    Topics: Animals; Cooking; Female; Food Analysis; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma; Male; Mice; Mutagens; Neoplasms, Experimental; Quinoxalines

1987
Metabolism of the mutagen MeIQx in vivo: metabolite screening by liquid chromatography-thermospray mass spectrometry.
    Biochemical and biophysical research communications, 1987, Nov-13, Volume: 148, Issue:3

    Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Mass Spectrometry; Mice; Quinoxalines

1987
Detection of IQ-type heterocyclic amines in dialysis fluid of uremic patients treated by peritoneal dialysis.
    Nihon Jinzo Gakkai shi, 1987, Volume: 29, Issue:9

    Topics: Adult; Female; Humans; Male; Middle Aged; Mutagens; Peritoneal Dialysis, Continuous Ambulatory; Quinolines; Quinoxalines; Uremia

1987
Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986, Volume: 24, Issue:5

    Topics: Animals; Biotransformation; Carbolines; Cricetinae; DNA; DNA Repair; Liver; Male; Mesocricetus; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity

1986
Presence of 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) in dialysate from patients with uremia.
    Biochemical and biophysical research communications, 1986, Aug-14, Volume: 138, Issue:3

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Quinoxalines; Renal Dialysis; Spectrum Analysis; Uremia

1986
Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx.
    Princess Takamatsu symposia, 1985, Volume: 16

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Carcinoma, Squamous Cell; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms

1985
Mammalian cell DNA damage by some heterocyclic food mutagens is correlated with their potency in the Ames test.
    Mutation research, 1985, Volume: 144, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; DNA; Food Analysis; Food Handling; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium

1985
An improved synthesis of 3,8-dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine ("MeIQx") and its 2-14C-labelled analogue.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1985, Volume: 39, Issue:1

    Topics: Chemical Phenomena; Chemistry; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mutagens; Quinoxalines

1985
Quantification of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC).
    Carcinogenesis, 1985, Volume: 6, Issue:8

    Topics: Animals; Cattle; Chromatography, Liquid; Meat; Mutagens; Quinolines; Quinoxalines

1985
Characterization of mutagenic fractions in beef extract and in cooked ground beef. Use of blue-cotton for efficient extraction.
    Gan, 1983, Volume: 74, Issue:4

    Topics: Adsorption; Animals; Cattle; Chromatography; Chromatography, High Pressure Liquid; Meat; Mutagens; Quinolines; Quinoxalines

1983
Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose.
    Mutation research, 1984, Volume: 126, Issue:3

    Topics: Chemical Phenomena; Chemistry; Creatinine; Glucose; Glycine; Hot Temperature; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Mutagens; Quinoxalines

1984
Qualitative and quantitative characterization of mutagens in commercial beef extract.
    Carcinogenesis, 1983, Volume: 4, Issue:7

    Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Food Analysis; Food Handling; Meat; Mutagens; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet

1983
DNA-binding of IQ, Me-IQ and Me-IQx, strong mutagens found in broiled foods.
    FEBS letters, 1982, Dec-27, Volume: 150, Issue:2

    Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cooking; DNA; Hot Temperature; Mutagens; Quinolines; Quinoxalines; Spectrophotometry; Thymus Gland

1982
Heterocyclic aromatic amine content of selected beef flavors.
    Mutation research, 1994, Volume: 320, Issue:1-2

    Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Creatine; Creatinine; Dose-Response Relationship, Drug; Flavoring Agents; Imidazoles; Linear Models; Meat Products; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium

1994
Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.
    Carcinogenesis, 1995, Volume: 16, Issue:11

    Topics: Adult; Arylamine N-Acetyltransferase; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mutagens; Oxidoreductases; Quinoxalines

1995
Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    Carcinogenesis, 1995, Volume: 16, Issue:7

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythrocebus patas; Female; Humans; Hydroxylation; Immunoblotting; Isoenzymes; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Polychlorinated Dibenzodioxins; Quinolines; Quinoxalines; Rats; Rifampin; Species Specificity; Substrate Specificity

1995
Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:6

    Topics: Adenoma; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; DNA Adducts; Glutathione Transferase; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344; Time Factors

1995
Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.
    Archives of biochemistry and biophysics, 1995, Jul-10, Volume: 320, Issue:2

    Topics: Amines; Animals; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Carcinogens; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression; Gene Transfer Techniques; Humans; Quinolines; Quinoxalines

1995
Heterocyclic amine content in fast-food meat products.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7

    Topics: Amines; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Food Contamination; Heterocyclic Compounds; Imidazoles; Maryland; Meat Products; Mutagenicity Tests; Mutagens; Quinoxalines; Reference Standards

1995
The consequences of fruit and vegetable fibre fermentation on their binding capacity for MeIQx and the effects of soluble fibre sources on the binding affinity of wheat bran preparations.
    Carcinogenesis, 1995, Volume: 16, Issue:8

    Topics: Carcinogens; Dietary Fiber; Fermentation; Fruit; Mucins; Quinoxalines; Triticum; Vegetables

1995
Effects of Maillard reaction products on mutagen formation in boiled pork juice.
    Mutagenesis, 1995, Volume: 10, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Meat; Mutagens; Picolines; Pyrazines; Quinolines; Quinoxalines; Swine; Thiophenes

1995
Suppressing effects of S phase post-treatment with carbolines on sister-chromatid exchanges induced by mitomycin C in Chinese hamster cells.
    Mutation research, 1993, Volume: 302, Issue:3

    Topics: Animals; Antimutagenic Agents; Carbolines; CHO Cells; Cricetinae; Mitomycin; Mutagens; Quinolines; Quinoxalines; S Phase; Sister Chromatid Exchange

1993
The effects of a soluble-fibre polysaccharide on the adsorption of carcinogens to insoluble dietary fibres.
    Chemico-biological interactions, 1995, Apr-14, Volume: 95, Issue:3

    Topics: 1-Octanol; Adsorption; Analysis of Variance; Benzo(a)pyrene; Carbolines; Carcinogens; Cellulose; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dietary Fiber; Dose-Response Relationship, Drug; Gum Arabic; Mutagenicity Tests; Mutagens; Octanols; Pyrenes; Quinoxalines; Solubility; Structure-Activity Relationship; Triticum; Water

1995
Formation of 2-amino-3-methylimidazo[4,5-f]quinoline- and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed mammalian phenol sulfotransferases.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:3

    Topics: Animals; Arylsulfotransferase; Cell Line; Cytosol; DNA, Complementary; Female; Gene Expression; Kinetics; Liver; Male; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfonic Acids

1995
[Improved microbiological assay of heterocyclic aromatic amines in cooked food].
    Zeitschrift fur Ernahrungswissenschaft, 1995, Volume: 34, Issue:1

    Topics: Amines; Animals; Carcinogens; Cooking; Food Analysis; Heterocyclic Compounds; Humans; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium; Sensitivity and Specificity

1995
Metabolism of the food-derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in nonhuman primates.
    Carcinogenesis, 1995, Volume: 16, Issue:6

    Topics: Animals; Biotransformation; Female; Macaca fascicularis; Magnetic Resonance Spectroscopy; Quinoxalines

1995
The effect of fibre source and fermentation on the apparent hydrophobic binding properties of wheat bran preparations for the mutagen 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Animals; Dietary Fiber; Fermentation; Kinetics; Mutagens; Quinoxalines; Triticum

1995
Dose-response studies of MeIQx in rat liver and liver DNA at low doses.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Animals; Biological Availability; Carbon Radioisotopes; Carcinogens; DNA; DNA Adducts; Dose-Response Relationship, Drug; Liver; Male; Mass Spectrometry; Mutagens; Nucleotides; Quinoxalines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tissue Distribution

1995
Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans.
    Cancer research, 1994, Dec-01, Volume: 54, Issue:23

    Topics: Carcinogens; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hot Temperature; Humans; Imidazoles; Male; Meat; Oxidoreductases; Polycyclic Compounds; Quinoxalines

1994
Effect of microwave pretreatment on heterocyclic aromatic amine mutagens/carcinogens in fried beef patties.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1994, Volume: 32, Issue:10

    Topics: Amines; Amino Acids; Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Cooking; Creatine; Creatinine; Food Irradiation; Glucose; Heterocyclic Compounds; Imidazoles; Meat; Microwaves; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella

1994
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer research, 1994, Jul-01, Volume: 54, Issue:13

    Topics: Acetyltransferases; Aflatoxin B1; Animals; Cell Line; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; RNA, Messenger

1994
Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1994, Volume: 32, Issue:7

    Topics: Animals; Cattle; Cooking; Hot Temperature; Imidazoles; Meat; Mutagens; Quinolines; Quinoxalines; Time Factors

1994
Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions.
    Carcinogenesis, 1994, Volume: 15, Issue:8

    Topics: Antioxidants; Carcinogens; Cooking; Fish Products; Imidazoles; Meat Products; Mutagens; Quinolines; Quinoxalines

1994
Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.
    Carcinogenesis, 1994, Volume: 15, Issue:8

    Topics: Animals; Dogs; Glucuronates; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1994
Prevention of heterocyclic amine formation by tea and tea polyphenols.
    Cancer letters, 1994, Aug-15, Volume: 83, Issue:1-2

    Topics: Antineoplastic Agents; Biflavonoids; Carcinogens; Catechin; Gallic Acid; Imidazoles; Quinoxalines; Tea

1994
Dose-response study of MeIQx carcinogenicity in F344 male rats.
    Cancer letters, 1994, Aug-15, Volume: 83, Issue:1-2

    Topics: Animals; Carcinogens; Female; Liver Neoplasms; Male; Neoplasms, Experimental; Quinoxalines; Rats; Rats, Inbred F344; Skin Neoplasms

1994
Effects of human and rat glutathione S-transferases on the covalent DNA binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro: a possible mechanism of organ specificity in their carcinogenesis.
    Cancer research, 1994, Sep-15, Volume: 54, Issue:18

    Topics: Animals; Colon; Cytosol; DNA; Glutathione; Glutathione Transferase; Humans; Imidazoles; Liver; Quinolines; Quinoxalines; Rats

1994
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.
    Cancer research, 1994, Apr-01, Volume: 54, Issue:7

    Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Female; Heterozygote; Hydroxylation; Imidazoles; Immunohistochemistry; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mutagenesis; Mutagens; Oxidoreductases; Quinoxalines

1994
Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human.
    Carcinogenesis, 1994, Volume: 15, Issue:5

    Topics: Animals; Biotransformation; Callithrix; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Immunoblotting; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Species Specificity

1994
In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1994, Volume: 32, Issue:5

    Topics: Animals; Antimutagenic Agents; Beverages; Biotransformation; Fruit; In Vitro Techniques; Male; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vegetables

1994
Studies on the mutagenic activation of heterocyclic amines by cynomolgus monkey, rat and human microsomes show that cynomolgus monkeys have a low capacity to N-oxidize the quinoxaline-type heterocyclic amines.
    Cancer letters, 1993, Sep-30, Volume: 73, Issue:2-3

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Indoles; Macaca fascicularis; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1993
Incorporation of carbon atoms from glucose into the food mutagens MeIQx and 4,8-DiMeIQx using 14C-labelled glucose in a model system.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: Carbon; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Glucose; Hot Temperature; Maillard Reaction; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella; Threonine

1993
Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: Acetyltransferases; Amino Acyl-tRNA Synthetases; Animals; Colon; Cytosol; DNA; Imidazoles; Kidney; Liver; Macaca fascicularis; Male; Myocardium; Phosphoric Monoester Hydrolases; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Species Specificity; Sulfotransferases

1993
The heterocyclic amines IQ and MeIQx show no promotive effect in a short-term in vivo liver carcinogenesis assay.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: 2-Acetylaminofluorene; Animals; Carcinogenicity Tests; Diethylnitrosamine; Glutathione Transferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Quinolines; Quinoxalines; Rats; Rats, Wistar

1993
Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: Animals; Chromatography, Thin Layer; DNA; Guanosine Diphosphate; Isotope Labeling; Liver; Male; Phosphorus Radioisotopes; Quinoxalines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Single-Strand Specific DNA and RNA Endonucleases

1993
Excretion of food-derived heterocyclic amine carcinogens into breast milk of lactating rats and formation of DNA adducts in the newborn.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Animal Feed; Animals; Animals, Newborn; Carcinogens; DNA; Female; Imidazoles; Kidney; Lactation; Liver; Mammary Glands, Animal; Milk; Mutagenicity Tests; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Salmonella typhimurium

1993
Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings.
    Carcinogenesis, 1993, Volume: 14, Issue:11

    Topics: Animals; Carbolines; Carcinogens; Cattle; Cooking; Fishes; Hot Temperature; Imidazoles; Meat; Quinoxalines; Swine; Time Factors

1993
Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res., 52: 6216-6223, 1992.
    Cancer research, 1993, Dec-15, Volume: 53, Issue:24

    Topics: Animals; Carcinogens, Environmental; Cattle; Cooking; Humans; Imidazoles; Meat; Quinoxalines

1993
Activation of the food derived carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat pleural cavity inflammatory cells.
    Carcinogenesis, 1993, Volume: 14, Issue:12

    Topics: Animals; Biotransformation; Carcinogens; Enzyme Inhibitors; Food Analysis; Free Radical Scavengers; Male; Mutagenicity Tests; Phagocytes; Pleura; Quinoxalines; Rats; Rats, Wistar; Superoxides

1993
Metabolism of the food-borne carcinogens 2-amino-3-methylimidazo-[4,5-f]quinoline and 2-amino-3,8- dimethylimidazo[4,5-f]-quinoxaline in the rat as a model for human biomonitoring.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Animals; Biotransformation; Blood Proteins; Carcinogens; Environmental Monitoring; Food Contamination; Humans; In Vitro Techniques; Liver; Male; Protein Binding; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley

1993
Exposure to heterocyclic amines.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Animals; Carcinogens; Female; Food Contamination; Heterocyclic Compounds; Humans; Imidazoles; Male; Middle Aged; Mutagens; Quinoxalines

1993
Immunoaffinity purification of dietary heterocyclic amine carcinogens.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Animals; Carcinogens; Cattle; Chromatography, Affinity; Diet; Food Contamination; Hot Temperature; Humans; Imidazoles; Meat; Quinoxalines; Rats

1993
32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
    Carcinogenesis, 1993, Volume: 14, Issue:7

    Topics: Animals; Autoradiography; Chromatography, High Pressure Liquid; DNA; DNA Damage; Haplorhini; Imidazoles; Liver; Mutagens; Phosphorus Radioisotopes; Polynucleotides; Quinolines; Quinoxalines

1993
Influence of dietary fat on DNA binding by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the mouse liver.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1993, Volume: 31, Issue:7

    Topics: Administration, Oral; Animals; Dietary Fats; DNA; Female; Liver; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Mutagens; Quinoxalines

1993
Quantification of the carcinogens 2-amino-3,8-dimethyl- and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in food using a combined assay based on gas chromatography-negative ion mass spectrometry.
    Journal of chromatography, 1993, Jul-02, Volume: 616, Issue:2

    Topics: Animals; Carcinogens; Cattle; Chickens; Gas Chromatography-Mass Spectrometry; Imidazoles; Isotope Labeling; Meat; Meat Products; Mutagens; Quinoxalines; Reference Standards; Swine

1993
Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Activation; Food; Hot Temperature; Imidazoles; Lung; Male; Mice; Microsomes; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinoxalines; Rats; Rats, Wistar

1993
Effects of chronic administration of low doses of 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline on glutathione S-transferase placental form-positive foci development in the livers of rats fed a choline-deficient diet.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:8

    Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Diet; Drug Administration Schedule; Glutathione Transferase; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344

1993
Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo.
    Carcinogenesis, 1993, Volume: 14, Issue:1

    Topics: Animals; Biotransformation; DNA Damage; Female; Humans; Imidazoles; Macaca fascicularis; Male; Microsomes, Liver; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Species Specificity; Tissue Distribution

1993
Effects of edible oils and fatty acids on the formation of mutagenic heterocyclic amines in a model system.
    Carcinogenesis, 1993, Volume: 14, Issue:1

    Topics: Amines; Creatinine; Dietary Fats, Unsaturated; Fatty Acids; Glucose; Glycine; Heterocyclic Compounds; Mutagens; Oxidation-Reduction; Quinoxalines

1993
Molecular dosimetry of the food-borne carcinogen MeIQx using adducts of serum albumin.
    Carcinogenesis, 1993, Volume: 14, Issue:2

    Topics: Adult; Animals; Blood Proteins; Carbon Radioisotopes; Carcinogens; Chromatography, Affinity; Food Contamination; Hemoglobins; Humans; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Protein Binding; Quinoxalines; Serum Albumin; Ultrafiltration

1993
Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.
    Molecular carcinogenesis, 1993, Volume: 7, Issue:2

    Topics: Alkalies; Animals; Autoradiography; Blotting, Southern; CHO Cells; Cooking; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; DNA, Bacterial; Electrophoresis; Endodeoxyribonucleases; Escherichia coli; Food Contamination; Intercalating Agents; Mutagens; Phosphorus Radioisotopes; Plasmids; Quinolines; Quinoxalines; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays

1993
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
    Biochemical pharmacology, 1993, Mar-09, Volume: 45, Issue:5

    Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug Synergism; Enzyme Induction; Glutathione Transferase; Liver; Methylcholanthrene; Phenobarbital; Quinoxalines; Rats; Xenobiotics

1993
Effects of enzyme induction on the distribution of the food carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-ss]-quinoxaline (MeIQx) in Ah-receptor- responsive- and Ah-receptor-non-responsive mice.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:1

    Topics: Animals; Carcinogens; Enzyme Induction; Hydroxylation; Kidney; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Quinoxalines; Safrole; Species Specificity; Spleen; Tissue Distribution

1995
Dietary caffeine reduces the genotoxicity of MeIQx in the host-mediated assay in mice.
    Nutrition and cancer, 1995, Volume: 24, Issue:2

    Topics: Animals; Caffeine; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Drug Interactions; Female; Liver; Mice; Mice, Inbred BALB C; Quinoxalines; Salmonella typhimurium

1995
Hepatocellular carcinoma induction in LEC rats by a low dose of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:1

    Topics: Alanine Transaminase; Animals; Body Weight; Carcinogens; Copper; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred Strains

1996
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:2

    Topics: Animals; Body Weight; Carcinogens; Diet; Glutathione Transferase; Guanine; Liver; Liver Neoplasms; Male; Organ Size; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1996
Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rabbit.
    Carcinogenesis, 1996, Volume: 17, Issue:3

    Topics: Age Factors; Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Quinoxalines; Rabbits

1996
Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.
    Carcinogenesis, 1996, Volume: 17, Issue:5

    Topics: Aged; Aged, 80 and over; Carcinogens; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA Adducts; Female; Humans; Imidazoles; Male; Middle Aged; Quinoxalines

1996
Inhibition of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-mediated DNA-adduct formation by chlorophyllin in Drosophila.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:4

    Topics: Animals; Antimutagenic Agents; Autoradiography; Chlorophyllides; DNA; DNA Adducts; DNA Damage; Drosophila; Female; Male; Mutagens; Phosphorus Radioisotopes; Quinoxalines

1996
Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.
    The Journal of biological chemistry, 1996, Aug-02, Volume: 271, Issue:31

    Topics: Base Sequence; Binding Sites; Carcinogens; DNA Adducts; DNA-Directed DNA Polymerase; DNA, Bacterial; Escherichia coli; Lac Operon; Molecular Sequence Data; Molecular Structure; Mutagens; Mutation; Quinoxalines; R Factors

1996
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice.
    Mutation research, 1996, Sep-23, Volume: 356, Issue:2

    Topics: Animals; Carbolines; DNA Adducts; Female; Gene Expression Regulation, Neoplastic; Genes, myc; Lac Operon; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Microsomes; Mutagenesis; Mutagens; Quinolines; Quinoxalines

1996
Metabolic processing and disposition of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Biotransformation; Carcinogens; Cooking; Food; Hot Temperature; Imidazoles; Macaca fascicularis; Mutagens; Quinolines; Quinoxalines

1995
Possible relationship between tissue distribution of DNA adducts and genotoxicity of food-derived heterocyclic amines.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Amines; Animals; Carcinoma, Hepatocellular; Cattle; Cooking; DNA Adducts; Fishes; Heterocyclic Compounds; Hot Temperature; Humans; Liver Neoplasms; Macaca fascicularis; Meat; Mutagens; Poultry; Primates; Quinolines; Quinoxalines; Tissue Distribution

1995
MeIQx (2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline): metabolism in humans and urinary metabolites in human populations.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Adult; Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Diet; Dietary Fats; Ethnicity; Humans; Male; Meat; Mutagens; Primates; Quinoxalines; Rats

1995
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; Humans; Imidazoles; Inflammation; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macaca fascicularis; Meat; Myocardium; Necrosis; Quinolines; Quinoxalines

1995
Laparoscopy as a means of monitoring liver tumor induction in nonhuman primates.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Equipment Design; Imidazoles; Laparoscopes; Laparoscopy; Liver Neoplasms, Experimental; Macaca mulatta; Palpation; Quinolines; Quinoxalines; Reproducibility of Results; Time Factors

1995
Genetic alterations in HCA-induced tumors.
    Princess Takamatsu symposia, 1995, Volume: 23

    Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazoles; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Point Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms

1995
Cytogenetic results from a chronic feeding study of MeIQx in mice.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1996, Volume: 34, Issue:8

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Chromosome Aberrations; Culture Media; Female; Femur; Fluorescein-5-isothiocyanate; Food Handling; In Situ Hybridization, Fluorescence; Lymphocytes; Mice; Mice, Inbred C57BL; Micronucleus Tests; Mutagens; Quinoxalines; Sister Chromatid Exchange

1996
Effect of commercial marinades on the mutagenic activity, sensory quality and amount of heterocyclic amines in chicken grilled under different conditions.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1996, Volume: 34, Issue:8

    Topics: Animals; Carcinogens; Chickens; Food Additives; Food Contamination; Food Handling; Food Preservation; Gas Chromatography-Mass Spectrometry; Hot Temperature; Humans; Imidazoles; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Taste

1996
An overview of cancer prevention.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1996, Volume: 5 Suppl 2

    Topics: beta Carotene; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Environmental Exposure; Humans; Imidazoles; Mutagens; Neoplasms; Neoplasms, Unknown Primary; Precancerous Conditions; Primary Prevention; Quinoxalines; Risk Factors

1996
Analysis of foods for heterocyclic aromatic amine carcinogens by solid-phase extraction and high-performance liquid chromatography.
    Journal of chromatography. A, 1997, Feb-28, Volume: 763, Issue:1-2

    Topics: Amines; Animals; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Heterocyclic Compounds; Imidazoles; Meat; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet

1997
The ability of two cooked food mutagens to induce aberrant crypt foci in mice.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1997, Volume: 6, Issue:1

    Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colon; Cooking; Deoxyguanosine; Diet; Disease Models, Animal; Female; Food, Fortified; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Mice; Mice, Inbred C57BL; Mutagens; Quinoxalines; Reference Values; Weight Gain

1997
Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1997, Volume: 35, Issue:5

    Topics: Amines; Animals; Chickens; Chromatography, High Pressure Liquid; Cooking; Food Analysis; Heterocyclic Compounds; Imidazoles; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium

1997
Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Animals; Arylamine N-Acetyltransferase; Cattle; Cytochrome P-450 CYP1A2; Female; Hot Temperature; Humans; Imidazoles; Male; Meat; Phenotype; Quinoxalines

1997
Quantification of mutagenic/carcinogenic heterocyclic amines, MeIQx, Trp-P-1, Trp-P-2 and PhIP, contributing highly to genotoxicity of river water.
    Mutation research, 1997, Sep-18, Volume: 393, Issue:1-2

    Topics: Amines; Animals; Carbolines; Carcinogens; Cellulose; Chromatography, High Pressure Liquid; Fresh Water; Imidazoles; In Vitro Techniques; Japan; Mutagenicity Tests; Mutagens; Quinoxalines; Rats; Salmonella typhimurium; Water Pollutants, Chemical

1997
Assessment of the human exposure to heterocyclic amines.
    Carcinogenesis, 1997, Volume: 18, Issue:10

    Topics: Aged; Carcinogens; Female; Food Handling; Hot Temperature; Humans; Imidazoles; Male; Middle Aged; Mutagens; Quinolines; Quinoxalines

1997
In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse.
    Mutation research, 1997, Dec-05, Volume: 395, Issue:1

    Topics: Amines; Animals; Brain; Carbolines; DNA Damage; Electrophoresis; Imidazoles; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Quinolines; Quinoxalines; Stomach

1997
Characterization of the carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in cooking aerosols under domestic conditions.
    Carcinogenesis, 1998, Volume: 19, Issue:2

    Topics: Aerosols; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Dose-Response Relationship, Drug; Mass Spectrometry; Mutagenicity Tests; Quinoxalines; Salmonella typhimurium

1998
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1998, Volume: 7, Issue:1

    Topics: Amines; Animals; Anticarcinogenic Agents; Antioxidants; Biological Assay; Carcinogens; Hydroquinones; Imidazoles; Liver Neoplasms, Experimental; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344

1998
Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines.
    Bioscience, biotechnology, and biochemistry, 1998, Volume: 62, Issue:2

    Topics: Animals; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Jejunum; Lactobacillus; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344; Streptococcus

1998
DNA damage in isolated rat hepatocytes exposed to C.I. pigment orange 5 and C.I. pigment yellow 12 by the alkaline comet assay.
    Teratogenesis, carcinogenesis, and mutagenesis, 1998, Volume: 18, Issue:1

    Topics: Alkalies; Animals; Azo Compounds; Biotransformation; Cell Separation; Coloring Agents; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis; Female; Liver; Mutagenicity Tests; Quinoxalines; Rats; Rats, Wistar

1998
[Effects of 16-week dietary administration of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in rats].
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences, 1997, Issue:115

    Topics: Animals; Carcinogens; Diet; Intestines; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344

1997
Effect of some cooked food mutagens on unscheduled DNA synthesis in cultured precision-cut rat, mouse and human liver slices.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1998, Volume: 36, Issue:6

    Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Autoradiography; Carbolines; Cooking; Culture Techniques; DNA; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Liver; Male; Mice; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Structure-Activity Relationship

1998
Inhibitory effects of antioxidants on formation of heterocyclic amines.
    Mutation research, 1998, Jun-18, Volume: 402, Issue:1-2

    Topics: Animals; Antimutagenic Agents; Antioxidants; Biotransformation; Imidazoles; Mutagens; Quinoxalines; Rats; Tea

1998
Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses. Comparison of human subjects and F344 rats.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:8

    Topics: Adult; Aged; Animals; Carbon Radioisotopes; Carcinogens; Dose-Response Relationship, Drug; Hemoglobins; Humans; Male; Mass Spectrometry; Protein Binding; Quinoxalines; Rats; Rats, Inbred F344; Sensitivity and Specificity; Serum Albumin

1998
Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.
    Chemical research in toxicology, 1998, Volume: 11, Issue:8

    Topics: Animals; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Humans; Imidazoles; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley

1998
Inhibitory effect of threo-9,10-dichlorostearic acid on the mutagenic activity of MeIQx, 2-AF and B[a]P in the Ames/Salmonella test.
    Mutation research, 1998, Aug-14, Volume: 416, Issue:3

    Topics: 4-Nitroquinoline-1-oxide; Antimutagenic Agents; Benzo(a)pyrene; Fluorenes; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium; Stearic Acids

1998
Application of accelerated mass spectrometry (AMS) in DNA adduct quantification and identification.
    Toxicology letters, 1998, Dec-28, Volume: 102-103

    Topics: DNA Adducts; Imidazoles; Mass Spectrometry; Quinoxalines; Sensitivity and Specificity

1998
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.
    Carcinogenesis, 1999, Volume: 20, Issue:4

    Topics: Animals; Biotransformation; Carbolines; Carcinogens, Environmental; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; DNA Damage; Dose-Response Relationship, Drug; Fibroblasts; Food; Hot Temperature; Humans; Imidazoles; Lymphocytes; Male; Mice; Mice, Inbred C3H; Micronucleus Tests; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Structure-Activity Relationship

1999
Urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in White, African-American, and Asian-American men in Los Angeles County.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1999, Volume: 8, Issue:5

    Topics: Adult; Asian; Black People; Humans; Imidazoles; Los Angeles; Male; Meat; Neoplasms; Quinoxalines; Surveys and Questionnaires; White People

1999
Mechanism of oxidative DNA damage induced by a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Amines; Animals; Catalase; Cattle; Chelating Agents; Chromatography, High Pressure Liquid; Copper; Cytosine; Deoxyguanosine; DNA; DNA Damage; Free Radical Scavengers; Genes, p53; Genes, ras; Hydrogen Peroxide; Models, Chemical; NAD; Oxidation-Reduction; Phenanthrolines; Quinoxalines; Spectrum Analysis; Thymine

1999
Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.
    Mutation research, 1999, Jun-25, Volume: 442, Issue:2

    Topics: Amines; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Isoquinolines; Mutagenicity Tests; Mutagens; NADPH-Ferrihemoprotein Reductase; Plasmids; Quinolines; Quinoxalines; Salmonella typhimurium

1999
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
    Cancer letters, 1999, Jul-19, Volume: 142, Issue:1

    Topics: Animals; Animals, Newborn; Biological Assay; Carcinogens; Imidazoles; Mice; Neoplasms, Experimental; Quinoxalines; Risk

1999
N-Acetyltransferase expression and DNA binding of N-hydroxyheterocyclic amines in human prostate epithelium.
    Carcinogenesis, 1999, Volume: 20, Issue:8

    Topics: Arylamine N-Acetyltransferase; Carcinogens; DNA; DNA Adducts; Epithelial Cells; Humans; Imidazoles; Isoenzymes; Male; Prostate; Prostatic Hyperplasia; Pyridines; Quinoxalines

1999
Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:6

    Topics: Animals; Carcinogens; Cytochrome P-450 CYP1A2; DNA Adducts; Female; Glutathione S-Transferase pi; Glutathione Transferase; Isoenzymes; Macaca fascicularis; Male; Neoplasms, Experimental; Quinoxalines

1999
Establishment of a Salmonella tester strain highly sensitive to mutagenic heterocylic amines.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Gene Expression; Humans; Imidazoles; Mutagenicity Tests; Mutagens; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Plasmids; Quinoxalines; Salmonella

1999
Free radical generation from heterocyclic amines by cytochrome b5 reductase in the presence of NADH.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Cytochrome Reductases; Cytochrome-B(5) Reductase; DNA Damage; Free Radicals; Humans; NAD; Quinolines; Quinoxalines; Recombinant Proteins

1999
Biomonitoring of heterocyclic aromatic amine metabolites in human urine.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Humans; Mutagens; Quinoxalines; Urinalysis

1999
Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Carcinogens; DNA Adducts; Dose-Response Relationship, Drug; Humans; Imidazoles; Macromolecular Substances; Mice; Quinoxalines; Rats

1999
Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Carcinogens; Diet; Food Contamination; Glutathione Transferase; Humans; Liver; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

1999
Comparative biotransformation studies of MeIQx and PhIP in animal models and humans.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Carbon Radioisotopes; Carcinogens; Colon; DNA Adducts; Humans; Imidazoles; Quinoxalines; Rats; Species Specificity

1999
Role of well-done, grilled red meat, heterocyclic amines (HCAs) in the etiology of human cancer.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Carcinogens; Colorectal Neoplasms; Humans; Imidazoles; Meat Products; Quinoxalines

1999
Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; Caffeine; Carcinogens; Colonic Neoplasms; Drug Synergism; Imidazoles; Liver Neoplasms, Experimental; Male; Phosphodiesterase Inhibitors; Quinolines; Quinoxalines; Rats; Rats, Inbred F344

1999
Carcinogenicity and mutagenicity of heterocyclic amines in transgenic mouse models.
    Cancer letters, 1999, Sep-01, Volume: 143, Issue:2

    Topics: Animals; DNA, Complementary; Genes, myc; Mice; Mice, Transgenic; Mutagenesis; Mutagens; Neoplasms, Experimental; Quinolines; Quinoxalines; Transforming Growth Factor alpha

1999
N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine.
    Cancer research, 1999, Oct-15, Volume: 59, Issue:20

    Topics: Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A2; Humans; Hydroxylamines; Mutagens; Oxidation-Reduction; Phenotype; Quinoxalines

1999
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
    Mutagenesis, 1999, Volume: 14, Issue:6

    Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cell Survival; CHO Cells; Cricetinae; Heterocyclic Compounds; Humans; Imidazoles; Liver Neoplasms; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella; Tumor Cells, Cultured

1999
Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments.
    Nature biotechnology, 2000, Volume: 18, Issue:1

    Topics: Animals; Animals, Genetically Modified; Benzo(a)pyrene; DNA Mutational Analysis; Dose-Response Relationship, Drug; Escherichia coli Proteins; Ethylnitrosourea; Female; Gene Dosage; Genetic Vectors; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Ribosomal Protein S9; Transgenes; Water Pollutants, Chemical; Zebrafish

2000
Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype.
    Carcinogenesis, 2000, Volume: 21, Issue:4

    Topics: Adult; Aged; Arylamine N-Acetyltransferase; Breast Neoplasms; Carcinogens; Cooking; Diet; Female; Genotype; Humans; Imidazoles; Meat; Middle Aged; Mutagens; Quinoxalines; Risk Factors

2000
In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.
    Mutation research, 2000, Jun-22, Volume: 468, Issue:1

    Topics: Administration, Oral; Animals; Bacterial Proteins; Cell Division; Colon; Diet; Dose-Response Relationship, Drug; Escherichia coli Proteins; Female; Intubation, Gastrointestinal; Lac Repressors; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Mutagens; Mutation; Quinoxalines; Repressor Proteins; Reticulocytes; Sex Factors

2000
Dietary heterocyclic amines and the risk of lung cancer among Missouri women.
    Cancer research, 2000, Jul-15, Volume: 60, Issue:14

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Diet; Female; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Lung Neoplasms; Middle Aged; Missouri; Multivariate Analysis; Quinoxalines; Risk Factors; Smoking

2000
Enhancing effects of Thai edible plants on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay.
    Cancer letters, 2000, Oct-01, Volume: 158, Issue:2

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Diet; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Plants, Medicinal; Quinoxalines; Rats; Rats, Inbred F344; Thailand

2000
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
    Nutrition and cancer, 2000, Volume: 37, Issue:2

    Topics: Alkylating Agents; Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Ethanol; Female; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Experimental; Organ Size; Precancerous Conditions; Propolis; Quinoxalines; Random Allocation; Rats; Rats, Inbred F344; Water

2000
Gel microdrop flow cytometry assay for low-dose studies of chemical and radiation cytotoxicity.
    Toxicology, 2001, Mar-07, Volume: 160, Issue:1-3

    Topics: Animals; Cell Survival; CHO Cells; Clone Cells; Colony-Forming Units Assay; Cricetinae; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flow Cytometry; Gamma Rays; Gels; Humans; Mice; Quinoxalines

2001
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2.
    Chemical research in toxicology, 2001, Volume: 14, Issue:2

    Topics: Animals; Biotransformation; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Mutagens; Quinoxalines; Rats; Theophylline

2001
The food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: a conformational analysis of its major DNA adduct and comparison with the 2-amino-3-methylimidazo[4,5-f]quinoline adduct.
    Chemical research in toxicology, 2001, Volume: 14, Issue:5

    Topics: Animals; Carcinogens; Computer Simulation; DNA Adducts; DNA Replication; Molecular Structure; Mutagens; Nucleic Acid Conformation; Quinolines; Quinoxalines

2001
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.
    Mutation research, 2001, Aug-22, Volume: 495, Issue:1-2

    Topics: Animals; Antimutagenic Agents; Catechin; Chromatography, High Pressure Liquid; Cooking; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidoreductases; Quinolines; Quinoxalines; Rats; Salmonella typhimurium; Tea

2001
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2.
    Chemical research in toxicology, 2001, Volume: 14, Issue:7

    Topics: Amines; Animals; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Inactivation, Metabolic; Kinetics; Microsomes, Liver; Mutagens; NADPH-Ferrihemoprotein Reductase; Quinoxalines; Rats; Recombinant Proteins; Species Specificity; Substrate Specificity; Theophylline

2001
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains.
    Environmental and molecular mutagenesis, 2001, Volume: 38, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbolines; Catalysis; Cell Transformation, Neoplastic; COS Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Escherichia coli; Lac Operon; Quinolines; Quinoxalines; Substrate Specificity

2001
Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.
    Carcinogenesis, 2001, Volume: 22, Issue:9

    Topics: Adult; Biomarkers; Biotransformation; Brassica; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Deoxyguanosine; DNA; Humans; Imidazoles; Lymphocytes; Male; Meat; Middle Aged; Quinoxalines

2001
Essential similarities between spontaneous and MeIQx-promoted aberrant crypt foci in the F344 rat colon.
    Cancer letters, 2001, Oct-30, Volume: 172, Issue:2

    Topics: Animals; Carcinogens; Colonic Neoplasms; Genes, ras; Male; Mutagens; Mutation; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344; Tumor Suppressor Protein p53

2001
Mutational spectra of benzo[a]pyrene and MeIQx in rpsL transgenic zebrafish embryos.
    Mutation research, 2002, Jan-15, Volume: 513, Issue:1-2

    Topics: Animals; Animals, Genetically Modified; Benzo(a)pyrene; Mutagens; Mutation; Quinoxalines; Ribosomal Proteins; Zebrafish

2002
Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: Cytochrome P-450 CYP1A2; Hepatocytes; Humans; Molecular Structure; Mutagens; Oxidation-Reduction; Quinoxalines; Tumor Cells, Cultured

2001
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:1

    Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Colon; Colonic Neoplasms; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Immunoblotting; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Smoking

2002
Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats.
    Cancer letters, 2002, May-08, Volume: 179, Issue:1

    Topics: Animals; Bromodeoxyuridine; Carbon Tetrachloride; Carcinogens; DNA; DNA Damage; DNA Primers; DNA-Formamidopyrimidine Glycosylase; Glutathione Transferase; Guanosine; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; N-Glycosyl Hydrolases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Transaminases

2002
Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.
    Chemical research in toxicology, 2002, Volume: 15, Issue:4

    Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization

2002
Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex.
    Journal of agricultural and food chemistry, 2002, May-08, Volume: 50, Issue:10

    Topics: Animals; Carcinogens; Eating; Female; Genotype; Harmine; Hot Temperature; Imidazoles; Male; Meat; Mutagens; Quinoxalines; Sex Characteristics; Swine

2002
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
    Cancer letters, 2002, Nov-08, Volume: 185, Issue:1

    Topics: Animals; Antinematodal Agents; Arylamine N-Acetyltransferase; Blotting, Western; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A2; DNA Primers; Drug Combinations; Drug Synergism; Enzyme Induction; Fenbendazole; Glutathione Transferase; Immunoenzyme Techniques; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction

2002
Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk.
    Mutation research, 2002, Sep-30, Volume: 506-507

    Topics: Adult; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases; Arylsulfotransferase; Carcinogens; Case-Control Studies; Colorectal Neoplasms; Cooking; Cytochrome P-450 CYP2A6; Diet; Eating; Environmental Exposure; Female; Genotype; Glutathione Transferase; Humans; Imidazoles; Male; Meat Products; Middle Aged; Mixed Function Oxygenases; Polymerase Chain Reaction; Quinoxalines; Sulfotransferases

2002
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2.
    Mutation research, 2002, Sep-30, Volume: 506-507

    Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Imidazoles; Liver; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Species Specificity; Theophylline

2002
Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan.
    Mutation research, 2002, Sep-30, Volume: 506-507

    Topics: Adult; Amines; Carcinogens; Cooking; Diet Surveys; Female; Heterocyclic Compounds; Humans; Imidazoles; Japan; Male; Meat; Middle Aged; Population; Prospective Studies; Quinolines; Quinoxalines

2002
Inhibition of human cytochrome P450 1B1, 1A1 and 1A2 by antigenotoxic compounds, purpurin and alizarin.
    Mutation research, 2002, Oct-31, Volume: 508, Issue:1-2

    Topics: Aflatoxin B1; Anthraquinones; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carmine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Escherichia coli; Humans; Mutagens; Quinoxalines; Recombinant Proteins; Salmonella typhimurium

2002
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine.
    Japanese journal of cancer research : Gann, 2002, Volume: 93, Issue:10

    Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2002
Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver.
    Mutagenesis, 2003, Volume: 18, Issue:1

    Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Enzyme Induction; Glucuronosyltransferase; Imidazoles; Liver; Liver Neoplasms, Experimental; Male; Membrane Proteins; Microsomes, Liver; Quinoxalines; Rats; Rats, Inbred F344; Smoke; Specific Pathogen-Free Organisms; Steroid Hydroxylases; Substrate Specificity

2003
A model system study of the inhibition of heterocyclic aromatic amine formation by organosulfur compounds.
    Journal of agricultural and food chemistry, 2002, Dec-18, Volume: 50, Issue:26

    Topics: Allyl Compounds; Amines; Creatinine; Disulfides; Glucose; Heterocyclic Compounds; Hot Temperature; Imidazoles; Phenylalanine; Quinoxalines; Sulfites; Sulfur Compounds; Volatilization

2002
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Effect of high water-holding capacity on the formation of heterocyclic amines in fried beefburgers.
    Journal of agricultural and food chemistry, 2003, Jul-16, Volume: 51, Issue:15

    Topics: Animals; Carcinogens; Cattle; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Quinoxalines; Water

2003
Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods.
    Mutation research, 2003, Aug-05, Volume: 539, Issue:1-2

    Topics: Amines; Animals; Animals, Domestic; Carcinogens; Food Analysis; Heterocyclic Compounds; Imidazoles; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium

2003
Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.
    Mutation research, 2003, Nov-10, Volume: 541, Issue:1-2

    Topics: Animals; Bacterial Proteins; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Escherichia coli Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagens; Mutation; Pentosyltransferases; Proteins; Quinoxalines

2003
Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
    Osaka city medical journal, 2003, Volume: 49, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cysteine; Deoxyguanosine; DNA; Genes, p53; Insulin-Like Growth Factor I; Liver Neoplasms, Experimental; Male; Nucleolus Organizer Region; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2003
Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Mar-25, Volume: 802, Issue:1

    Topics: Animals; Antimutagenic Agents; Cell Line; Cricetinae; Imidazoles; Mutagens; Phytoalexins; Plant Extracts; Quinoxalines; Resveratrol; Sesquiterpenes; Stilbenes; Terpenes

2004
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
    Gastroenterology, 2004, Volume: 126, Issue:5

    Topics: alpha-Fetoproteins; Animals; beta Catenin; Cell Cycle Proteins; Cytoskeletal Proteins; Disease Models, Animal; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Deletion; Gene Frequency; Genes, myc; Genomic Instability; Liver Neoplasms; Loss of Heterozygosity; Mice; Mice, Transgenic; Mutation; Phenotype; Quinoxalines; Trans-Activators; Transcription Factors; Transforming Growth Factor alpha

2004
Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.
    Toxicology, 2004, Jul-01, Volume: 199, Issue:2-3

    Topics: Amines; Animals; Carbolines; Carcinogens; Cooking; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Female; Harmine; Heterocyclic Compounds; Humans; Meat; Mutagens; Quinoxalines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2004
No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 81, Issue:2

    Topics: Animals; Animals, Genetically Modified; Body Weight; Carcinogenicity Tests; Carcinogens; Colorimetry; Cooking; DNA; Glutathione Transferase; Immunohistochemistry; Liver; Male; Mutagenicity Tests; Mutagens; No-Observed-Adverse-Effect Level; Organ Size; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344

2004
Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.
    Chemical research in toxicology, 2004, Volume: 17, Issue:8

    Topics: Amines; Animals; Carbolines; Cattle; Chromatography, Liquid; Food; Heterocyclic Compounds; Humans; Male; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Spectrometry, Mass, Electrospray Ionization

2004
Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Carcinogenesis, 2005, Volume: 26, Issue:1

    Topics: Adenocarcinoma; Animals; Anticoagulants; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Imidazoles; Immunohistochemistry; Male; Mice; Mice, Inbred ICR; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Restriction Mapping; Trans-Activators

2005
Heterocyclic amines in some Swedish cooked foods industrially prepared or from fast food outlets and restaurants.
    Molecular nutrition & food research, 2004, Volume: 48, Issue:4

    Topics: Amines; Animals; Carcinogens; Cooking; Food Analysis; Food Handling; Heterocyclic Compounds; Imidazoles; Meat; Mutagens; Quinolines; Quinoxalines; Restaurants; Sweden

2004
Effect of the South African traditional meat, biltong, on cancer-associated enzymes CYP2E1 and CYP1A2.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2004, Volume: 94, Issue:11

    Topics: Adult; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Diet; Female; Humans; Male; Meat; Quinoxalines; South Africa

2004
Induction of DNA-adducts and increase of 8-hydroxy-2-deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans-breast milk exposure to 2-amino-3,8-dimethylimidazo [4,5-f ]quinoxaline (MeIQx) in rats.
    Cancer science, 2004, Volume: 95, Issue:12

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Deoxyguanosine; Diet; DNA Adducts; Female; Glutathione Transferase; Humans; Lactation; Liver; Liver Neoplasms, Experimental; Male; Milk, Human; Placenta; Precancerous Conditions; Pregnancy; Quinoxalines; Rats; Rats, Inbred F344

2004
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 84, Issue:2

    Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diet; Drug Therapy, Combination; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinolines; Quinoxalines

2005
A comparison of genotoxicity between three common heterocyclic amines and acrylamide.
    Mutation research, 2005, Feb-07, Volume: 580, Issue:1-2

    Topics: Acrylamide; Animals; Dose-Response Relationship, Drug; Erythrocytes; Heterocyclic Compounds; Imidazoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Mutagens; Quinolines; Quinoxalines; Structure-Activity Relationship

2005
Addition of various carbohydrates to beef burgers affects the formation of heterocyclic amines during frying.
    Journal of agricultural and food chemistry, 2004, Dec-15, Volume: 52, Issue:25

    Topics: Animals; Carbohydrates; Cattle; Chemical Phenomena; Chemistry, Physical; Dietary Fiber; Heterocyclic Compounds; Hot Temperature; Meat; Quinoxalines; Solanum tuberosum; Starch

2004
Inhibitory effects of heterocyclic amine-induced DNA adduct formation in mouse liver and lungs by beer.
    Journal of agricultural and food chemistry, 2005, Feb-09, Volume: 53, Issue:3

    Topics: Animals; Beer; Carbolines; DNA Adducts; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Mutagens; Quinoxalines

2005
Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians.
    Chemical research in toxicology, 2005, Volume: 18, Issue:3

    Topics: Creatinine; Diet, Vegetarian; Humans; Imidazoles; Male; Meat; Mutagens; Quinoxalines; Spectrometry, Mass, Electrospray Ionization

2005
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Oct-25, Volume: 825, Issue:2

    Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Quinolines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2005
Nitric oxide-mediated nitrosation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline potentiated by hemin and myeloperoxidase.
    Chemical research in toxicology, 2005, Volume: 18, Issue:6

    Topics: Animals; Carcinogens; Cattle; Cells, Cultured; Drug Synergism; Hemin; Humans; Neutrophils; Nitrosation; Peroxidase; Quinoxalines; Reactive Nitrogen Species; Spectrometry, Mass, Electrospray Ionization

2005
Suppression of glutathione S-transferase placental form-positive foci development in rat hepatocarcinogenesis by Chlorella pyrenoidosa.
    Oncology reports, 2005, Volume: 14, Issue:2

    Topics: Animals; Body Weight; Chlorella; Diet; Diethylnitrosamine; Eating; Glutathione Transferase; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms; Male; Organ Size; Quinoxalines; Rats; Rats, Inbred F344; Treatment Outcome

2005
Novel antimutagenic factors derived from the edible mushroom Agrocybe cylindracea.
    Mutation research, 2005, Oct-03, Volume: 586, Issue:2

    Topics: Agaricales; Animals; Antimutagenic Agents; DNA Damage; Drosophila; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium

2005
Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
    Cancer research, 2005, Sep-01, Volume: 65, Issue:17

    Topics: Adenoma; Aged; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Female; Food Preservation; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Quinoxalines

2005
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold.
    Cancer science, 2005, Volume: 96, Issue:11

    Topics: Adenoma; Administration, Oral; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP2E1; DNA Damage; Dose-Response Relationship, Drug; Enzyme Induction; Ethanol; Liver Neoplasms; Male; Quinoxalines; Rats; Rats, Inbred F344; RNA, Messenger

2005
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
    Carcinogenesis, 2006, Volume: 27, Issue:5

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cysteine; Down-Regulation; Glutathione Transferase; Insulin-Like Growth Factor I; Liver Neoplasms; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Silver Staining; Time Factors

2006
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.
    Cancer letters, 2006, Jan-18, Volume: 231, Issue:2

    Topics: Animals; Carcinogens; Glutathione S-Transferase pi; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred BN; Rats, Inbred F344

2006
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
    Cancer letters, 2006, Feb-08, Volume: 232, Issue:2

    Topics: Acetyltransferases; Animals; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Male; Membrane Glycoproteins; Oligonucleotide Array Sequence Analysis; Proteoglycans; Quinoxalines; Rats; Rats, Inbred F344; Syndecan-2

2006
Stability and reactivity of 2-nitrosoamino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Chemical research in toxicology, 2006, Volume: 19, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Imidazoles; Liver; Male; Mice; Mice, Inbred C57BL; Nitrosamines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors

2006
PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor.
    Chemical research in toxicology, 2005, Volume: 18, Issue:10

    Topics: Binding, Competitive; Carcinogens; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Furans; Hot Temperature; Humans; Imidazoles; Meat; Quinoxalines

2005
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
    International journal of cancer, 2006, Sep-01, Volume: 119, Issue:5

    Topics: Acetylation; Arylamine N-Acetyltransferase; Carcinogens; Genotype; Humans; Imidazoles; Phenotype; Polymorphism, Single Nucleotide; Quinoxalines

2006
Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol.
    Toxicologic pathology, 2006, Volume: 34, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Central Nervous System Depressants; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Ethanol; Glutathione S-Transferase pi; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Male; No-Observed-Adverse-Effect Level; Proliferating Cell Nuclear Antigen; Quinoxalines; Rats; Rats, Inbred F344

2006
Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats.
    Cancer science, 2006, Volume: 97, Issue:6

    Topics: 5-Methylcytosine; Animals; Carcinogens; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Immunohistochemistry; Liver Diseases; Liver Neoplasms, Experimental; Male; Quinoxalines; Rats; Thioacetamide

2006
Enhancement of phase II enzyme activity by purpurin resulting in the suppression of MeIQx-DNA-adduct formation in mice.
    Mutation research, 2007, Jan-10, Volume: 626, Issue:1-2

    Topics: Animals; Anthraquinones; DNA Adducts; Male; Mice; Mice, Inbred C57BL; Quinoxalines

2007
Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:4

    Topics: Amines; Animals; Cattle; Cooking; Heterocyclic Compounds; Imidazoles; Meat; Mutagens; Quinoxalines

2007
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.
    Oncology reports, 2007, Volume: 17, Issue:4

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Gene Expression; Gene Expression Profiling; Liver; Liver Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344

2007
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:7

    Topics: Acetylation; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Carcinogens; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Damage; DNA Repair; Gene Expression Regulation, Enzymologic; Humans; Mutagenesis; Mutation; Quinoxalines; Tandem Mass Spectrometry; Transfection

2007
Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model system and beef patties.
    Molecular nutrition & food research, 2007, Volume: 51, Issue:8

    Topics: Animals; Antioxidants; Catechin; Cattle; Chromatography, High Pressure Liquid; Cinnamates; Creatinine; Depsides; Diet; Flavanones; Flavonoids; Glucose; Imidazoles; Meat; Models, Chemical; Phenols; Phenylalanine; Polyphenols; Quinoxalines; Rosmarinic Acid

2007
Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:8

    Topics: Animals; Carbolines; Carcinogens; Case-Control Studies; Chickens; China; Cohort Studies; Creatinine; Follow-Up Studies; Humans; Imidazoles; Male; Meat; Middle Aged; Population Surveillance; Prospective Studies; Quinoxalines; Smoking; Swine

2007
What is a practical threshold?
    Toxicologic pathology, 2007, Volume: 35, Issue:6

    Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Glutathione S-Transferase pi; Liver; Quinoxalines; Rats

2007
Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties.
    Journal of agricultural and food chemistry, 2007, Dec-12, Volume: 55, Issue:25

    Topics: Animals; Carcinogens; Cattle; Citrus; Fruit; Garlic; Heterocyclic Compounds; Hot Temperature; Meat; Olive Oil; Onions; Plant Oils; Quinoxalines

2007
Inhibitory effect of fruit extracts on the formation of heterocyclic amines.
    Journal of agricultural and food chemistry, 2007, Dec-12, Volume: 55, Issue:25

    Topics: Ananas; Animals; Cattle; Fruit; Heterocyclic Compounds; Hot Temperature; Imidazoles; Malus; Meat; Plant Extracts; Proanthocyanidins; Quinoxalines; Sambucus; Seeds; Vitis

2007
Meat and meat mutagens and risk of prostate cancer in the Agricultural Health Study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:1

    Topics: Case-Control Studies; Cohort Studies; Cooking; Diet; Humans; Male; Meat; Middle Aged; Mutagens; Polycyclic Aromatic Hydrocarbons; Prospective Studies; Prostatic Neoplasms; Quinoxalines

2008
Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:3

    Topics: Anticarcinogenic Agents; Antimutagenic Agents; Carbolines; Carcinogens; Food Handling; Heterocyclic Compounds; Hot Temperature; Imidazoles; Lactobacillus; Meat; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines

2008
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Brain; Cell Line; Dantrolene; Dogs; Imidazoles; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Prazosin; Quinoxalines; Swine; Testis; Triamterene; Xenobiotics

2008
Carcinogenic risk of heterocyclic amines in combination - assessment with a liver initiation model.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:6

    Topics: Amines; Animals; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; DNA, Complementary; Glutathione Transferase; Hepatocytes; Heterocyclic Compounds; Imidazoles; Liver; Liver Neoplasms; Male; Oligonucleotide Array Sequence Analysis; Quinoxalines; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Risk

2008
Evidence of a threshold-effect for 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline liver carcinogenicity in F344/DuCrj rats.
    Toxicologic pathology, 2008, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma, Liver Cell; Administration, Oral; Animal Feed; Animals; Carcinogens; Carcinoma, Hepatocellular; Deoxyguanosine; DNA Adducts; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Liver Neoplasms; Longevity; Male; No-Observed-Adverse-Effect Level; Precancerous Conditions; Quinoxalines; Rats; Rats, Inbred F344

2008
Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods.
    Journal of agricultural and food chemistry, 2008, Jun-25, Volume: 56, Issue:12

    Topics: Amines; Animals; Carbolines; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat; Mutagens; Quinoxalines

2008
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:8

    Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Chitin; Chitosan; Colonic Neoplasms; Diethylnitrosamine; Female; Glutathione Peroxidase; Liver Neoplasms, Experimental; Male; Mammary Neoplasms, Animal; Organ Size; Quinoxalines; Rats; Rats, Inbred F344

2008
Effect of beer/red wine marinades on the formation of heterocyclic aromatic amines in pan-fried beef.
    Journal of agricultural and food chemistry, 2008, Nov-26, Volume: 56, Issue:22

    Topics: Animals; Beer; Carcinogens; Cattle; Food Handling; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Meat; Quinolines; Quinoxalines; Sensation; Wine

2008
Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer.
    Analytical chemistry, 2009, Jan-15, Volume: 81, Issue:2

    Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Cells, Cultured; DNA Adducts; Hepatocytes; Humans; Liver; Male; Mouth Mucosa; Quinoxalines; Rats; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization

2009
Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk.
    Cancer research, 2009, Feb-01, Volume: 69, Issue:3

    Topics: Aged; Animals; Case-Control Studies; Cattle; Chickens; Female; Humans; Imidazoles; Italy; Lung Neoplasms; Male; Meat; Meat Products; Middle Aged; Mutagens; Quinoxalines

2009
Ability of probiotic Lactobacillus casei DN 114001 to bind or/and metabolise heterocyclic aromatic amines in vitro.
    European journal of nutrition, 2009, Volume: 48, Issue:7

    Topics: Amines; Aminopyridines; Analysis of Variance; Cells, Cultured; Chromatography, High Pressure Liquid; Colony Count, Microbial; Comet Assay; DNA Damage; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Inactivation, Metabolic; Lacticaseibacillus casei; Mutagens; Probiotics; Quinolines; Quinoxalines; Spectrophotometry, Ultraviolet; Time Factors

2009
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:11

    Topics: Acetylation; Animals; Animals, Congenic; Arylamine N-Acetyltransferase; Carcinogens; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Female; Gene Targeting; Genetic Predisposition to Disease; Imidazoles; Liver Neoplasms; Mutagens; Polymorphism, Genetic; Quinoxalines; Rats; Rats, Inbred F344; Rats, Inbred WKY; Time Factors

2009
Hollow fibre-supported liquid membrane extraction and LC-MS/MS detection for the analysis of heterocyclic amines in urine samples.
    Molecular nutrition & food research, 2009, Volume: 53, Issue:12

    Topics: Analytic Sample Preparation Methods; Carbolines; Carcinogens; Chromatography, High Pressure Liquid; Harmine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Imidazoles; Limit of Detection; Microchemistry; Mutagens; Pyridines; Quinoxalines; Reproducibility of Results; Tandem Mass Spectrometry

2009
Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
    Mutation research, 2010, Feb-03, Volume: 684, Issue:1-2

    Topics: Animals; Arylamine N-Acetyltransferase; Base Sequence; CHO Cells; Cricetinae; Cricetulus; DNA Damage; Humans; Molecular Sequence Data; Mutagenesis; Mutagens; Quinolines; Quinoxalines; Transfection

2010
A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.
    Chemical research in toxicology, 2010, Apr-19, Volume: 23, Issue:4

    Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Imidazoles; Meat; Metabolome; Quinoxalines; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization

2010
A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.
    Cancer research, 2010, Mar-15, Volume: 70, Issue:6

    Topics: Cohort Studies; Colorectal Neoplasms; Cooking; Diet; Female; Humans; Imidazoles; Male; Meat; Middle Aged; Prospective Studies; Quinoxalines; Surveys and Questionnaires; United States

2010
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells.
    Toxicology and applied pharmacology, 2010, Jun-01, Volume: 245, Issue:2

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cytochrome P-450 Enzyme System; DNA Damage; Dose-Response Relationship, Drug; Humans; Imidazoles; Oxidative Stress; Polymerase Chain Reaction; Quinoxalines

2010
Meat mutagens and breast cancer in postmenopausal women--a cohort analysis.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:5

    Topics: Adult; Breast Neoplasms; Cohort Studies; Female; Humans; Imidazoles; Meat; Middle Aged; Mutagens; Nurses; Postmenopause; Quinoxalines; Risk Factors; Surveys and Questionnaires

2010
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression.
    Toxicologic pathology, 2010, Volume: 38, Issue:4

    Topics: Analysis of Variance; Animals; Arylamine N-Acetyltransferase; Benzoflavones; beta-Naphthoflavone; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochromes; Drug Synergism; Enzyme Inhibitors; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Organ Specificity; Quinoxalines; Rats; Rats, Inbred F344

2010
Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary.
    Journal of food science, 2010, Volume: 75, Issue:2

    Topics: Animals; Antioxidants; Cattle; Cooking; Ethanol; Food Analysis; Food Handling; Gas Chromatography-Mass Spectrometry; Heterocyclic Compounds, 2-Ring; Imidazoles; Meat Products; Plant Extracts; Quinoxalines; Rosmarinus; Solid Phase Microextraction; Time Factors; Water

2010
Effects of (+)-catechin and (-)-epicatechin on heterocyclic amines-induced oxidative DNA damage.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:1

    Topics: Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Imidazoles; Oxidation-Reduction; Quinoxalines

2011
Capillary liquid chromatography with diode array and mass spectrometry detection for heterocyclic aromatic amine determination in ready-to-eat food treated with electron-beam irradiation.
    Journal of chromatography. A, 2010, Oct-22, Volume: 1217, Issue:43

    Topics: Acetonitriles; Animals; Cheese; Chromatography, Liquid; Food Analysis; Food Irradiation; Harmine; Linear Models; Mass Spectrometry; Quinoxalines; Reproducibility of Results; Salmon; Seafood; Sensitivity and Specificity

2010
Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.
    Toxicology and applied pharmacology, 2010, Nov-15, Volume: 249, Issue:1

    Topics: Amines; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Quinoxalines; Receptors, Aryl Hydrocarbon

2010
Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    The Journal of toxicological sciences, 2010, Volume: 35, Issue:5

    Topics: Animals; Blotting, Western; Body Weight; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytosol; Drug Synergism; Escherichia coli Proteins; Female; Genotype; Liver; Mice; Mice, Transgenic; Microsomes, Liver; Mutagens; Organ Size; Pentosyltransferases; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53

2010
Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice.
    The Journal of toxicological sciences, 2010, Volume: 35, Issue:5

    Topics: Animals; Cocarcinogenesis; Colonic Neoplasms; Dextran Sulfate; Escherichia coli Proteins; Male; Mice; Mice, Transgenic; Mutagens; Pentosyltransferases; Quinoxalines; Tumor Suppressor Protein p53

2010
Meat consumption and risk of esophageal and gastric cancer in a large prospective study.
    The American journal of gastroenterology, 2011, Volume: 106, Issue:3

    Topics: Adenocarcinoma; Aged; Carcinogens; Carcinoma, Squamous Cell; Cardia; Esophageal Neoplasms; Feeding Behavior; Female; Follow-Up Studies; Humans; Iron; Male; Meat; Middle Aged; Mutagens; Odds Ratio; Prospective Studies; Quinoxalines; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; United States

2011
Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.
    Carcinogenesis, 2011, Volume: 32, Issue:2

    Topics: Aged; Amines; Aryl Hydrocarbon Receptor Nuclear Translocator; Arylamine N-Acetyltransferase; Biotransformation; Carcinogens; Case-Control Studies; Colorectal Neoplasms; Female; Genetic Variation; Genotype; Humans; Imidazoles; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Polymorphism, Single Nucleotide; Quinoxalines; Risk Factors

2011
Selected heterocyclic amines.
    Report on carcinogens : carcinogen profiles, 2004, Volume: 11

    Topics: Amines; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Environmental Exposure; Female; Government Regulation; Guidelines as Topic; Heterocyclic Compounds; Humans; Imidazoles; Macaca fascicularis; Male; Mice; Models, Biological; Quinolines; Quinoxalines; Rats; United States

2004
Ultraperformance liquid chromatography-tandem mass spectrometry method for biomonitoring cooked meat carcinogens and their metabolites in human urine.
    Analytical chemistry, 2011, Feb-01, Volume: 83, Issue:3

    Topics: Carcinogens; Chromatography, Liquid; Cooking; Humans; Imidazoles; Meat; Molecular Structure; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Urinalysis

2011
Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study.
    Breast cancer research and treatment, 2011, Volume: 129, Issue:3

    Topics: Adult; Aged; Breast Neoplasms; Carcinogens; Case-Control Studies; Cooking; Eating; Female; Humans; Meat; Middle Aged; Mutagens; Postmenopause; Premenopause; Quinoxalines; Regression Analysis; Risk Factors; Tennessee

2011
Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice.
    Mutation research, 2011, Aug-16, Volume: 723, Issue:2

    Topics: Animals; Antimutagenic Agents; DNA Adducts; Fruit; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mutagens; Phenols; Quinoxalines; Vitis

2011
In vitro mutagen binding and antimutagenic activity of human Lactobacillus rhamnosus 231.
    Anaerobe, 2011, Volume: 17, Issue:5

    Topics: Acridine Orange; Antimutagenic Agents; Biotransformation; Culture Media; Feces; Humans; Hydrogen-Ion Concentration; Lacticaseibacillus rhamnosus; Methylnitronitrosoguanidine; Microbial Viability; Mutagens; Phenylenediamines; Quinoxalines

2011
Inhibitory activity of Asian spices on heterocyclic amines formation in cooked beef patties.
    Journal of food science, 2011, Volume: 76, Issue:8

    Topics: Amines; Animals; Antioxidants; Cattle; Cooking; Curcuma; Hot Temperature; Imidazoles; Meat Products; Oils, Volatile; Phenols; Plant Extracts; Quinoxalines; Rosmarinus; Spices

2011
Cytochrome P450-mediated metabolism and DNA binding of 2-amino-1,7-dimethylimidazo[4,5-g]quinoxaline and its carcinogenic isomer 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in mice.
    Chemical research in toxicology, 2012, Feb-20, Volume: 25, Issue:2

    Topics: Animals; Carcinogens; Colon; Cytochrome P-450 Enzyme System; DNA Adducts; Female; Humans; Liver; Mice; Mice, Inbred C57BL; Microsomes, Liver; Pancreas; Quinoxalines; Recombinant Proteins; Rectum

2012
[Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2011, Volume: 29, Issue:8

    Topics: Amines; Animals; Carcinogens; Chromatography, High Pressure Liquid; Food Analysis; Food Contamination; Heterocyclic Compounds; Imidazoles; Poultry Products; Quinoxalines; Solid Phase Extraction

2011
Occurrence of heterocyclic amines in cooked meat products.
    Meat science, 2012, Volume: 90, Issue:3

    Topics: Amines; Animals; Cattle; Chickens; Chromatography, High Pressure Liquid; Consumer Product Safety; Cooking; Fishes; Heterocyclic Compounds; Hot Temperature; Imidazoles; Meat Products; Mutagens; Quinoxalines; Risk Factors; Swine

2012
Protective effects of xanthohumol against the genotoxicity of heterocyclic aromatic amines MeIQx and PhIP in bacteria and in human hepatoma (HepG2) cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:3-4

    Topics: Cell Line, Tumor; Comet Assay; Flavonoids; Genomic Instability; Humans; Imidazoles; Mutagens; Propiophenones; Quinoxalines; Real-Time Polymerase Chain Reaction; Salmonella typhimurium

2012
Plant extracts, spices, and essential oils inactivate Escherichia coli O157:H7 and reduce formation of potentially carcinogenic heterocyclic amines in cooked beef patties.
    Journal of agricultural and food chemistry, 2012, Apr-11, Volume: 60, Issue:14

    Topics: Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Carcinogens; Cattle; Clove Oil; Escherichia coli O157; Fruit; Hot Temperature; Imidazoles; Malus; Meat; Oils, Volatile; Olea; Onions; Plant Extracts; Quinoxalines; Spices

2012
Formation of heterocyclic amines during cooking of duck meat.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2012, Volume: 29, Issue:11

    Topics: Amines; Animals; Carbolines; China; Chromatography, High Pressure Liquid; Cooking; Ducks; Food Contamination; Harmine; Heterocyclic Compounds; Hot Temperature; Imidazoles; Maillard Reaction; Meat; Microwaves; Mutagens; Quinolines; Quinoxalines; Solid Phase Extraction; Time Factors

2012
Meat intake and risk of non-Hodgkin lymphoma.
    Cancer causes & control : CCC, 2012, Volume: 23, Issue:10

    Topics: Adult; Aged; Arylamine N-Acetyltransferase; Case-Control Studies; Dietary Fats; Female; Humans; Isoenzymes; Lymphoma, Non-Hodgkin; Male; Meat; Middle Aged; Mutagens; Oleic Acid; Quinoxalines; Risk Factors; United States

2012
Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and β-naphthoflavone.
    The Journal of toxicological sciences, 2012, Volume: 37, Issue:5

    Topics: Animals; beta-Naphthoflavone; Carbon Tetrachloride; Carcinogens; Cyclooxygenase 2; Cytochrome P-450 CYP1A1; Diethylnitrosamine; Drug Synergism; Lipid Peroxidation; Liver Neoplasms, Experimental; Male; Oligonucleotide Array Sequence Analysis; Omeprazole; Proton Pump Inhibitors; Quinoxalines; Rats; Rats, Inbred F344

2012
[Determination of 14 heterocyclic aromatic amines in wine by liquid chromatography-ion trap-time of flight tandem mass spectrometry].
    Se pu = Chinese journal of chromatography, 2012, Volume: 30, Issue:7

    Topics: Amines; Chromatography, Liquid; Food Contamination; Heterocyclic Compounds; Imidazoles; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Wine

2012
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.
    Oncogene, 2013, Oct-10, Volume: 32, Issue:41

    Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Female; Food; Genomic Instability; Humans; Imidazoles; Long Interspersed Nucleotide Elements; Mice; Quinoxalines; Receptors, Aryl Hydrocarbon

2013
Meat-related compounds and colorectal cancer risk by anatomical subsite.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cooking; Feeding Behavior; Female; Humans; Imidazoles; Logistic Models; Male; Meat; Meat Products; Middle Aged; Nitrates; Nitrites; Pennsylvania; Poultry; Quinoxalines; Rectal Neoplasms; Risk Factors; Surveys and Questionnaires

2013
Formation of heterocyclic amines in salami and ham pizza toppings during baking of frozen pizza.
    Journal of food science, 2013, Volume: 78, Issue:6

    Topics: Amines; Animals; Carbolines; Chromatography, High Pressure Liquid; Color; Consumer Behavior; Cooking; Freezing; Harmine; Hot Temperature; Humans; Imidazoles; Maillard Reaction; Meat Products; Quinoxalines; Swine; Taste

2013
Helicobacter pylori infection and antioxidants can modulate the genotoxic effects of heterocyclic amines in gastric mucosa cells.
    Molecular biology reports, 2013, Volume: 40, Issue:8

    Topics: Adult; Ascorbic Acid; Breath Tests; Carbon Isotopes; Comet Assay; DNA Damage; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Imidazoles; Male; Melatonin; Middle Aged; Poland; Quinoxalines; Statistics, Nonparametric

2013
Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.
    Archives of toxicology, 2013, Volume: 87, Issue:8

    Topics: Animals; Body Weight; Cell Proliferation; Cyclin D1; Cytochrome P-450 CYP1A2; Drug Synergism; Fluoroquinolones; Glucuronosyltransferase; Hepatocytes; Liver; Male; Mice; Mice, Transgenic; Mutagens; Mutation; Oligonucleotide Array Sequence Analysis; Phenobarbital; Quinoxalines

2013
Genotoxicity and induction of DNA damage responsive genes by food-borne heterocyclic aromatic amines in human hepatoma HepG2 cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 59

    Topics: Biotransformation; Carcinogens; Cell Cycle; Cell Survival; DNA Breaks; DNA Damage; Food Contamination; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Hot Temperature; Humans; Imidazoles; Mutagens; Quinolines; Quinoxalines

2013
Formation and mitigation of heterocyclic aromatic amines in fried pork.
    Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 2013, Volume: 30, Issue:9

    Topics: Animals; Antioxidants; Carcinogens; China; Cooking; Fast Foods; Food Contamination; Food Preservatives; Heterocyclic Compounds; Imidazoles; Meat; Meat Products; Mutagens; Plant Extracts; Plant Leaves; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Sasa; Sus scrofa

2013
Chemical state of heterocyclic aromatic amines in grilled beef: evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 62

    Topics: Amines; Animals; Carbolines; Cattle; Cooking; Digestion; Humans; Hydrolysis; Imidazoles; Male; Meat; Mutagens; Quinolines; Quinoxalines; Solvents

2013
Red meat-derived heterocyclic amines increase risk of colon cancer: a population-based case-control study.
    Nutrition and cancer, 2013, Volume: 65, Issue:8

    Topics: Aged; Amines; Case-Control Studies; Colonic Neoplasms; Confidence Intervals; Cooking; Female; Humans; Logistic Models; Male; Meat; Middle Aged; Mutagens; Nutrition Assessment; Odds Ratio; Polycyclic Aromatic Hydrocarbons; Quinoxalines; Risk Factors; Surveys and Questionnaires

2013
Dietary vitamin E effects on the formation of heterocyclic amines in grilled lean beef.
    Meat science, 2014, Volume: 96, Issue:2 Pt A

    Topics: Amines; Animals; Antioxidants; Cattle; Chromatography, High Pressure Liquid; Cooking; Diet; Harmine; Imidazoles; Meat; Muscle, Skeletal; Mutagens; Quinoxalines; Salmonella; Vitamin E

2014
Effect of enhancement on the formation of heterocyclic amines in cooked pork loins: preliminary studies.
    Meat science, 2014, Volume: 98, Issue:2

    Topics: Amines; Animals; Cooking; Creatine; Heterocyclic Compounds; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Meat; Phosphates; Quinoxalines; Salts; Swine; Water

2014
Optimised extraction of heterocyclic aromatic amines from blood using hollow fibre membrane liquid-phase microextraction and triple quadrupole mass spectrometry.
    Journal of chromatography. A, 2014, Sep-05, Volume: 1358

    Topics: Animals; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; Cooking; Humans; Hydrogen-Ion Concentration; Imidazoles; Liquid Phase Microextraction; Meat; Mutagens; Polypropylenes; Quinoxalines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
Impact of different pan-frying conditions on the formation of heterocyclic aromatic amines and sensory quality in fried bacon.
    Food chemistry, 2015, Feb-01, Volume: 168

    Topics: Animals; Cooking; Food Handling; Imidazoles; Meat Products; Quinoxalines; Temperature

2015
Effect of six Chinese spices on heterocyclic amine profiles in roast beef patties by ultra performance liquid chromatography-tandem mass spectrometry and principal component analysis.
    Journal of agricultural and food chemistry, 2014, Oct-08, Volume: 62, Issue:40

    Topics: Amines; Animals; Capsicum; Cattle; Chromatography, High Pressure Liquid; Cooking; Cuminum; Foeniculum; Food Analysis; Harmine; Heterocyclic Compounds; Imidazoles; Meat; Piper nigrum; Principal Component Analysis; Pyridines; Quinolines; Quinoxalines; Spices; Tandem Mass Spectrometry

2014
Evaluation of maillard reaction variables and their effect on heterocyclic amine formation in chemical model systems.
    Journal of food science, 2015, Volume: 80, Issue:2

    Topics: Carbohydrates; Carcinogens; Chromatography, Reverse-Phase; Creatinine; Hot Temperature; Maillard Reaction; Meat; Models, Chemical; Mutagens; Quinolines; Quinoxalines; Threonine; Water

2015
Impact of Precursors Creatine, Creatinine, and Glucose on the Formation of Heterocyclic Aromatic Amines in Grilled Patties of Various Animal Species.
    Journal of food science, 2015, Volume: 80, Issue:11

    Topics: Acids, Heterocyclic; Amines; Amino Acids; Animals; Cattle; Chromatography, High Pressure Liquid; Cooking; Creatine; Creatinine; Glucose; Horses; Hot Temperature; Humans; Imidazoles; Meat; Mutagens; Poultry; Pyridines; Quinoxalines; Sheep; Swine

2015
Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.
    Cancer, 2016, Jan-01, Volume: 122, Issue:1

    Topics: Carcinoma, Renal Cell; Case-Control Studies; Disease Susceptibility; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Imidazoles; Kidney Neoplasms; Male; Meat; Middle Aged; Mutagens; Quinoxalines; Risk Factors; United States

2016
Disposition of the Dietary Mutagen 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Healthy and Pancreatic Cancer Compromised Humans.
    Chemical research in toxicology, 2016, Mar-21, Volume: 29, Issue:3

    Topics: Case-Control Studies; Diet; DNA Adducts; Humans; Mutagens; Pancreatectomy; Pancreatic Neoplasms; Quinoxalines

2016
Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts.
    Environmental and molecular mutagenesis, 2016, Volume: 57, Issue:9

    Topics: Activation, Metabolic; Carbolines; Cell Culture Techniques; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA Adducts; Flow Cytometry; Humans; Imidazoles; Quinoxalines; Real-Time Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; T-Lymphocytes

2016
Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.
    Analytical chemistry, 2016, 12-20, Volume: 88, Issue:24

    Topics: Aged; Animals; Carcinogens; Cattle; Chromatography, Liquid; Cooking; DNA Adducts; Humans; Imidazoles; Limit of Detection; Male; Meat; Middle Aged; Nicotiana; Prostate; Quinoxalines; Smoke; Tandem Mass Spectrometry

2016
Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells.
    Archives of toxicology, 2017, Volume: 91, Issue:9

    Topics: Activation, Metabolic; Animals; Arylamine N-Acetyltransferase; Arylsulfotransferase; Cytochrome P-450 CYP1A2; Heterocyclic Compounds; Humans; Imidazoles; Mutagenicity Tests; Mutagens; Quinoxalines; Recombinant Proteins

2017
Gut Microbial Transformation of the Dietary Imidazoquinoxaline Mutagen MelQx Reduces Its Cytotoxic and Mutagenic Potency.
    Toxicological sciences : an official journal of the Society of Toxicology, 2017, 09-01, Volume: 159, Issue:1

    Topics: 3T3 Cells; Animals; Carcinogens; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred BALB C; Mutagens; Quinoxalines; Spectrum Analysis

2017
Inhibition effects of flavonoids on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline formation and alkoxy radical scavenging capabilities of flavonoids in a model system.
    Journal of the science of food and agriculture, 2018, Volume: 98, Issue:8

    Topics: Alcohols; Carcinogens; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Flavonoids; Free Radical Scavengers; Models, Chemical; Quinoxalines

2018
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.
    Neurotoxicology, 2018, Volume: 65

    Topics: Amines; Animals; Carbolines; Dopaminergic Neurons; Dose-Response Relationship, Drug; Harmine; Heterocyclic Compounds, 3-Ring; Mesencephalon; Molecular Structure; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Quinolines; Quinoxalines; Rats

2018
The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:10

    Topics: Adult; Amines; Animals; Carbolines; Feces; Female; Food Contamination; Gastrointestinal Microbiome; Glyceraldehyde; Harmine; Heterocyclic Compounds, Fused-Ring; Humans; Male; Microsomes, Liver; Middle Aged; Propane; Quinolines; Quinoxalines; Rats, Wistar

2019
2-Amino-3,8-dimethylimidazo[4,5-
    Journal of agricultural and food chemistry, 2019, Jul-17, Volume: 67, Issue:28

    Topics: Animals; Autophagosomes; Cell Line; Embryonic Stem Cells; Humans; Lipid Metabolism; Lipids; Mice; Microtubule-Associated Proteins; Quinoxalines; Transcription Factors

2019
Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport.
    Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 59

    Topics: Animals; Biotransformation; Cell Line; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Liver; Male; Mutagens; Quinoxalines; Rats; Rats, Inbred F344

2019
Revealing a key inhibitory mechanism of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline via trapping of methylglyoxal.
    Journal of food science, 2020, Volume: 85, Issue:7

    Topics: Amines; Animals; Cooking; Fish Products; Hot Temperature; Hydroxybenzoates; Mutagens; Pyridoxamine; Pyruvaldehyde; Quinoxalines; Tilapia; Vitamins

2020
Mitigation of heterocyclic aromatic amines in cooked meat. Part I: Informed selection of antioxidants based on molecular modeling.
    Food chemistry, 2020, Nov-30, Volume: 331

    Topics: Amines; Animals; Antioxidants; Cattle; Cooking; Heterocyclic Compounds; Models, Molecular; Origanum; Plant Extracts; Quinolines; Quinoxalines; Red Meat; Resveratrol; Structure-Activity Relationship; Tea; Wine

2020
Identification of acrolein as the reactive carbonyl responsible for the formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
    Food chemistry, 2021, May-01, Volume: 343

    Topics: Acrolein; Animals; Creatinine; Hot Temperature; Hydrogen-Ion Concentration; Quinoxalines

2021
Effects of ten vegetable oils on heterocyclic amine profiles in roasted beef patties using UPLC-MS/MS combined with principal component analysis.
    Food chemistry, 2021, Jun-15, Volume: 347

    Topics: Amines; Animals; Cattle; Chromatography, High Pressure Liquid; Cooking; Heterocyclic Compounds; Imidazoles; Limit of Detection; Meat; Plant Oils; Principal Component Analysis; Quinoxalines; Tandem Mass Spectrometry

2021