2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and furafylline

2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with furafylline in 7 studies

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (57.14)	18.2507
2000's	3 (42.86)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boobis, AR; Davies, DS; Gooderham, NJ; Lewis, I; Murray, BP; Rendell, NB; Rich, KJ	1
Boobis, AR; Davies, DS; Gooderham, NJ; Murray, BP; Murray, S	1
Boobis, AR; Davies, DS; de la Torre, R; Farré, M; Gooderham, NJ; Lynch, AM; Murray, S; Segura, J; Solans, A	1
Boobis, AR; Davies, DS; de la Torre, R; Gooderham, NJ; Lynch, A; Murray, S; Segura, J	1
Fay, LB; Guengerich, FP; Guillouzo, A; Huynh-Ba, T; Kerriguy, N; Langouët, S; Markovic, J; Turesky, RJ; Welti, DH	1
Guengerich, FP; Huynh-Ba, T; Langouët, S; Parisod, V; Turesky, RJ	1
Guengerich, FP; Guillouzo, A; Langouët, S; Turesky, RJ	1

Reviews

1 review(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and furafylline

Article	Year
Systemic exposure to dietary heterocyclic amines in man. Princess Takamatsu symposia, 1995, Volume: 23 Topics: Animals; Biotransformation; Cattle; Cooking; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Diet; Environmental Exposure; Enzyme Inhibitors; Hot Temperature; Humans; Imidazoles; Meat; Metabolic Clearance Rate; Mutagens; Quinoxalines; Theophylline	1995

Trials

1 trial(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and furafylline

Article	Year
CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer research, 1994, Jan-01, Volume: 54, Issue:1 Topics: Adult; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Imidazoles; Male; Oxidoreductases; Phenacetin; Quinoxalines; Theophylline	1994

Other Studies

5 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and furafylline

Article	Year
N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. Carcinogenesis, 1992, Volume: 13, Issue:12 Topics: Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diet; Humans; Hydroxylation; Mass Spectrometry; Microsomes, Liver; Mutagens; Oxidation-Reduction; Oxidoreductases; Quinoxalines; Theophylline	1992
Exposure to, and activation of, the food derived mutagenic heterocyclic amine MeIQx. Progress in clinical and biological research, 1990, Volume: 340B Topics: Animals; Biotransformation; Cattle; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dogs; Female; Guinea Pigs; Hot Temperature; Humans; Intestinal Absorption; Isoenzymes; Male; Meat; Mesocricetus; Mice; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinoxalines; Rabbits; Salmonella typhimurium; Species Specificity; Theophylline	1990
Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2. Chemical research in toxicology, 2001, Volume: 14, Issue:2 Topics: Animals; Biotransformation; Cell Separation; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Inactivation, Metabolic; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Mutagens; Quinoxalines; Rats; Theophylline	2001
Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2. Chemical research in toxicology, 2001, Volume: 14, Issue:7 Topics: Amines; Animals; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Hepatocytes; Humans; Inactivation, Metabolic; Kinetics; Microsomes, Liver; Mutagens; NADPH-Ferrihemoprotein Reductase; Quinoxalines; Rats; Recombinant Proteins; Species Specificity; Substrate Specificity; Theophylline	2001
Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. Mutation research, 2002, Sep-30, Volume: 506-507 Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Hepatocytes; Humans; Imidazoles; Liver; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Species Specificity; Theophylline	2002