2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline has been researched along with 2-amino-3,4-dimethylimidazo(4,5-f)quinoline in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (23.81) | 18.7374 |
| 1990's | 22 (52.38) | 18.2507 |
| 2000's | 5 (11.90) | 29.6817 |
| 2010's | 4 (9.52) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Akaike, T; Ando, M; Kojima, Y; Maeda, H; Nagao, M; Sato, K | 1 |
| Brams, A; de Meester, C | 1 |
| Alexander, J; Holme, JA; Wallin, H | 1 |
| Esumi, H; Kudo, M; Ogura, T; Sugimura, T | 1 |
| Fukushima, S; Hakoi, K; Hasegawa, R; Ito, N; Iwasaki, S; Nagao, M; Shirai, T; Sugimura, T; Takaba, K; Wakabayashi, K | 1 |
| Burgess, WM; Huggett, A; McManus, ME; Quattrochi, LC; Tukey, RH; Veronese, ME | 1 |
| Ayrton, AD; Flatt, PR; Ioannides, C; Keele, A; Lewis, DF; Walker, R | 1 |
| Ayrton, AD; Bass, SL; Flatt, PR; Ioannides, C; Trinick, J; Walker, R | 1 |
| Alexander, J; Wallin, H | 1 |
| Alldrick, AJ; Rowland, IR; Wise, A | 1 |
| Abu-Shakra, A; Ioannides, C; Walker, R | 1 |
| Liu, ZC; Nagao, M; Sugimura, T; Wakabayashi, K; Zhang, XM | 1 |
| Manabe, S; Wada, O; Yanagisawa, H | 1 |
| Beamand, JA; Howes, AJ; Rowland, IR | 1 |
| Hasegawa, H; Kato, T; Ohgaki, H; Sato, S; Suenaga, M; Sugimura, T; Takayama, S | 1 |
| Caderni, G; Dolara, P; Salvadori, M; Santoni, G | 1 |
| Hayashi, K; Kasai, H; Miyazawa, T; Nishimura, S; Watanabe, T; Yokoyama, S | 1 |
| Diachenko, GW; Hargraves, WA; Jackson, LS; Stroup, WH | 1 |
| Deguchi, T; Hashimoto, H; Itoh, S; Kamataki, T; Sawada, M; Yanagawa, Y | 1 |
| Hao, NJ; Lee, H; Lin, MY | 1 |
| Sasaki, YF; Shirasu, Y | 1 |
| Wild, D | 1 |
| Jägerstad, M; Johansson, MA | 1 |
| Burgard, S; Edenharder, R; John, K; Kurz, P; Seeger, K | 1 |
| Bohr, VA; Nouso, K; Schut, HA; Snyderwine, EG | 1 |
| Boobis, AR; Gooderham, NJ; Lynch, AM; Murray, S | 1 |
| Adamson, RH; Dalgard, DW; Farb, A; Snyderwine, EG; Sugimura, T; Takayama, S; Thorgeirsson, SS; Thorgeirsson, UP; Virmani, R | 1 |
| Inoue, R; Kakiuchi, H; Makino, H; Nagao, M; Sugimura, T; Ushijima, T | 1 |
| Augustsson, K; Jägerstad, M; Skog, K; Steineck, G | 1 |
| Akasaka, M; Matsusaka, N; Nishidate, E; Ohta, T; Saga, A; Sasaki, YF; Tsuda, S; Watanabe-Akanuma, M | 1 |
| Aryal, P; Guengerich, FP; Oda, Y; Shimada, T; Terashita, T; Yoshikawa, K | 1 |
| Darroudi, F; Knasmüller, S; Kundi, M; Land, SJ; Parzefall, W; Sanyal, R; Schwab, CE; Wang, CY | 1 |
| Batty, SM; Boverhof, DR; Josephy, PD | 1 |
| Hanaoka, T; Kataoka, H; Kobayashi, M; Nishioka, S; Tsugane, S | 1 |
| Bianchi, F; Careri, M; Corradini, C; Elviri, L; Mangia, A; Zagnoni, I | 1 |
| Ferreira, IM; Melo, A; Petisca, C; Pinho, O; Viegas, O | 1 |
| Szterk, A | 1 |
| Fukushima, S; Gi, M; Kakehashi, A; Matsumoto, M; Wanibuchi, H | 1 |
| Agim, ZS; Cannon, JR; Cruz-Hernandez, A; McCabe, GP; Montenegro, PC; Rochet, JC | 1 |
| Beer, F; Bunzel, D; Bunzel, M; Franz, CMAP; Huch, M; Kulling, SE; Urbat, F | 1 |
| Angénieux, M; Blinet, P; Chaloin, L; Chevolleau, S; Debrauwer, L; Engel, E; Mercier, F; Meurillon, M | 1 |
2 review(s) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and 2-amino-3,4-dimethylimidazo(4,5-f)quinoline
| Article | Year |
|---|---|
Exposure to and activation of dietary heterocyclic amines in humans.
Topics: Animals; Biological Availability; Biotransformation; Carcinogens; Colorectal Neoplasms; Cooking; Cytochrome P-450 CYP1A2; Diet; DNA Adducts; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Liver; Meat; Mutagenicity Tests; Mutagens; Proteins; Quinolines; Quinoxalines; Rats; Risk Assessment | 1995 |
Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; DNA; DNA Adducts; Dose-Response Relationship, Drug; Female; Glutathione Transferase; Guanosine; Humans; Liver; Male; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 2016 |
40 other study(ies) available for 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline and 2-amino-3,4-dimethylimidazo(4,5-f)quinoline
| Article | Year |
|---|---|
Evidence of direct generation of oxygen free radicals from heterocyclic amines by NADPH/cytochrome P-450 reductase in vitro.
Topics: Amines; Cyclic N-Oxides; Cytochrome P-450 Enzyme System; DNA; Electron Spin Resonance Spectroscopy; Heterocyclic Compounds; Hydroxylation; Kinetics; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; NADP; NADPH-Ferrihemoprotein Reductase; Pentetic Acid; Quinolines; Quinoxalines; Reactive Oxygen Species; Superoxides | 1992 |
Mutagenic potency of heterocyclic amines towards Salmonella typhimurium; possible causes of variability in the results observed.
Topics: Dose-Response Relationship, Drug; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Reproducibility of Results; Salmonella typhimurium | 1992 |
Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carcinogens; DNA; Male; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains | 1992 |
Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines.
Topics: Animals; Carcinoma, Squamous Cell; Codon; Ear Neoplasms; Ear, External; Gene Expression Regulation, Neoplastic; Genes, ras; Male; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Sebaceous Gland Neoplasms | 1991 |
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
Topics: Animals; Body Weight; Carbolines; Carcinogens; Drug Synergism; Enzyme Induction; Glutathione Transferase; Imidazoles; Immunohistochemistry; Liver; Liver Neoplasms; Male; Organ Size; Quinolines; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
Topics: 2-Acetylaminofluorene; Adolescent; Adult; Aged; Benzo(a)pyrene; Cell Line; Child; Cytochrome P-450 Enzyme System; Food Contamination; Gene Expression; Humans; Hydroxylation; Imidazoles; Microsomes, Liver; Middle Aged; Quinolines; Quinoxalines | 1990 |
Mechanism of the in vitro antimutagenic action of retinol.
Topics: Animals; Biotransformation; Computer Simulation; In Vitro Techniques; Male; Models, Biological; Mutagenicity Tests; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Submitochondrial Particles; Vitamin A | 1990 |
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Topics: Animals; Biotransformation; Carbolines; Carcinogens; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylamide Gel; Insulin; Isoenzymes; Male; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Mutagenicity Tests; Mutagens; Niacinamide; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains | 1988 |
A model system for studying covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein.
Topics: Animals; Biotransformation; Carcinogens; DNA; Food Analysis; In Vitro Techniques; Microsomes, Liver; Mutagens; Protein Binding; Quinolines; Quinoxalines; Rats | 1988 |
The hepatic conversion of some heterocyclic amines to bacterial mutagens is modified by dietary fat and cholesterol.
Topics: Animals; Biotransformation; Cattle; Cholesterol, Dietary; Dietary Fats; Hot Temperature; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1987 |
Effect of tryptamine on the mutagenic activity of 2-amino-3-methylimidazo(4,5-f) quinoline (IQ) and related azaarenes in the Ames test.
Topics: Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytosol; Enzyme Induction; In Vitro Techniques; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity; Tryptamines | 1987 |
Mutagenic and carcinogenic heterocyclic amines in Chinese cooked foods.
Topics: China; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cooking; Diet; Food Analysis; Heterocyclic Compounds; Imidazoles; Mutagenicity Tests; Mutagens; Mutation; Neoplasms; Quinolines; Quinoxalines | 1988 |
Detection of IQ-type heterocyclic amines in dialysis fluid of uremic patients treated by peritoneal dialysis.
Topics: Adult; Female; Humans; Male; Middle Aged; Mutagens; Peritoneal Dialysis, Continuous Ambulatory; Quinolines; Quinoxalines; Uremia | 1987 |
Induction of unscheduled DNA synthesis in rat and hamster hepatocytes by cooked food mutagens.
Topics: Animals; Biotransformation; Carbolines; Cricetinae; DNA; DNA Repair; Liver; Male; Mesocricetus; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Carcinogenicities in mice and rats of IQ, MeIQ, and MeIQx.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma; Carcinoma, Squamous Cell; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms | 1985 |
Mammalian cell DNA damage by some heterocyclic food mutagens is correlated with their potency in the Ames test.
Topics: 2-Acetylaminofluorene; Animals; DNA; Food Analysis; Food Handling; Mice; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella typhimurium | 1985 |
DNA-binding of IQ, Me-IQ and Me-IQx, strong mutagens found in broiled foods.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cooking; DNA; Hot Temperature; Mutagens; Quinolines; Quinoxalines; Spectrophotometry; Thymus Gland | 1982 |
Heterocyclic aromatic amine content of selected beef flavors.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Creatine; Creatinine; Dose-Response Relationship, Drug; Flavoring Agents; Imidazoles; Linear Models; Meat Products; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium | 1994 |
Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.
Topics: Amines; Animals; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Carcinogens; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expression; Gene Transfer Techniques; Humans; Quinolines; Quinoxalines | 1995 |
Effects of Maillard reaction products on mutagen formation in boiled pork juice.
Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Maillard Reaction; Meat; Mutagens; Picolines; Pyrazines; Quinolines; Quinoxalines; Swine; Thiophenes | 1995 |
Suppressing effects of S phase post-treatment with carbolines on sister-chromatid exchanges induced by mitomycin C in Chinese hamster cells.
Topics: Animals; Antimutagenic Agents; Carbolines; CHO Cells; Cricetinae; Mitomycin; Mutagens; Quinolines; Quinoxalines; S Phase; Sister Chromatid Exchange | 1993 |
[Improved microbiological assay of heterocyclic aromatic amines in cooked food].
Topics: Amines; Animals; Carcinogens; Cooking; Food Analysis; Heterocyclic Compounds; Humans; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Salmonella typhimurium; Sensitivity and Specificity | 1995 |
Occurrence of mutagenic/carcinogenic heterocyclic amines in meat and fish products, including pan residues, prepared under domestic conditions.
Topics: Antioxidants; Carcinogens; Cooking; Fish Products; Imidazoles; Meat Products; Mutagens; Quinolines; Quinoxalines | 1994 |
In vitro effect of vegetable and fruit juices on the mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Antimutagenic Agents; Beverages; Biotransformation; Fruit; In Vitro Techniques; Male; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Vegetables | 1994 |
Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.
Topics: Alkalies; Animals; Autoradiography; Blotting, Southern; CHO Cells; Cooking; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; DNA, Bacterial; Electrophoresis; Endodeoxyribonucleases; Escherichia coli; Food Contamination; Intercalating Agents; Mutagens; Phosphorus Radioisotopes; Plasmids; Quinolines; Quinoxalines; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1993 |
Studies on the carcinogenic and myocardial effects of 2-amino-3-methylimidazo [4,5-f] quinoline (IQ) in nonhuman primates.
Topics: Administration, Oral; Animals; Carcinogens; Cooking; DNA Adducts; Fibrosis; Heart; Hot Temperature; Humans; Imidazoles; Inflammation; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Macaca fascicularis; Meat; Myocardium; Necrosis; Quinolines; Quinoxalines | 1995 |
Genetic alterations in HCA-induced tumors.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Female; Food; Genes, p53; Genes, ras; Humans; Imidazoles; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Point Mutation; Quinolines; Quinoxalines; Rats; Rats, Inbred F344; Stomach Neoplasms | 1995 |
Assessment of the human exposure to heterocyclic amines.
Topics: Aged; Carcinogens; Female; Food Handling; Hot Temperature; Humans; Imidazoles; Male; Middle Aged; Mutagens; Quinolines; Quinoxalines | 1997 |
In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse.
Topics: Amines; Animals; Brain; Carbolines; DNA Damage; Electrophoresis; Imidazoles; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Mutagens; Quinolines; Quinoxalines; Stomach | 1997 |
Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase.
Topics: Amines; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Aromatic; Isoquinolines; Mutagenicity Tests; Mutagens; NADPH-Ferrihemoprotein Reductase; Plasmids; Quinolines; Quinoxalines; Salmonella typhimurium | 1999 |
Genotoxic effects of heterocyclic aromatic amines in human derived hepatoma (HepG2) cells.
Topics: Amines; Animals; Arylamine N-Acetyltransferase; Carbolines; Carcinogens; Carcinoma, Hepatocellular; Cell Line; Cell Survival; CHO Cells; Cricetinae; Heterocyclic Compounds; Humans; Imidazoles; Liver Neoplasms; Mutagenicity Tests; Mutagens; Quinolines; Quinoxalines; Rats; Salmonella; Tumor Cells, Cultured | 1999 |
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carbolines; Catalysis; Cell Transformation, Neoplastic; COS Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Escherichia coli; Lac Operon; Quinolines; Quinoxalines; Substrate Specificity | 2001 |
Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan.
Topics: Adult; Amines; Carcinogens; Cooking; Diet Surveys; Female; Heterocyclic Compounds; Humans; Imidazoles; Japan; Male; Meat; Middle Aged; Population; Prospective Studies; Quinolines; Quinoxalines | 2002 |
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity.
Topics: Acetonitriles; Amines; Buffers; Carbolines; Chromatography, Liquid; Formates; Harmine; Heterocyclic Compounds; Hydrogen-Ion Concentration; Imidazoles; Quinolines; Quinoxalines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Effect of beer/red wine marinades on the formation of heterocyclic aromatic amines in pan-fried beef.
Topics: Animals; Beer; Carcinogens; Cattle; Food Handling; Heterocyclic Compounds; Hot Temperature; Humans; Imidazoles; Meat; Quinolines; Quinoxalines; Sensation; Wine | 2008 |
Selected heterocyclic amines.
Topics: Amines; Animals; Animals, Newborn; Carcinogenicity Tests; Carcinogens; Cells, Cultured; Environmental Exposure; Female; Government Regulation; Guidelines as Topic; Heterocyclic Compounds; Humans; Imidazoles; Macaca fascicularis; Male; Mice; Models, Biological; Quinolines; Quinoxalines; Rats; United States | 2004 |
Chemical state of heterocyclic aromatic amines in grilled beef: evaluation by in vitro digestion model and comparison of alkaline hydrolysis and organic solvent for extraction.
Topics: Amines; Animals; Carbolines; Cattle; Cooking; Digestion; Humans; Hydrolysis; Imidazoles; Male; Meat; Mutagens; Quinolines; Quinoxalines; Solvents | 2013 |
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons.
Topics: Amines; Animals; Carbolines; Dopaminergic Neurons; Dose-Response Relationship, Drug; Harmine; Heterocyclic Compounds, 3-Ring; Mesencephalon; Molecular Structure; Nerve Degeneration; Neurites; Neurons; Primary Cell Culture; Quinolines; Quinoxalines; Rats | 2018 |
The Human Fecal Microbiota Metabolizes Foodborne Heterocyclic Aromatic Amines by Reuterin Conjugation and Further Transformations.
Topics: Adult; Amines; Animals; Carbolines; Feces; Female; Food Contamination; Gastrointestinal Microbiome; Glyceraldehyde; Harmine; Heterocyclic Compounds, Fused-Ring; Humans; Male; Microsomes, Liver; Middle Aged; Propane; Quinolines; Quinoxalines; Rats, Wistar | 2019 |
Mitigation of heterocyclic aromatic amines in cooked meat. Part I: Informed selection of antioxidants based on molecular modeling.
Topics: Amines; Animals; Antioxidants; Cattle; Cooking; Heterocyclic Compounds; Models, Molecular; Origanum; Plant Extracts; Quinolines; Quinoxalines; Red Meat; Resveratrol; Structure-Activity Relationship; Tea; Wine | 2020 |