2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and benzo(a)pyrene

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine has been researched along with benzo(a)pyrene in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.63)18.7374
1990's5 (13.16)18.2507
2000's16 (42.11)29.6817
2010's15 (39.47)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Burgess, WM; Huggett, A; McManus, ME; Quattrochi, LC; Tukey, RH; Veronese, ME1
Felton, JS; Fuscoe, JC; Healy, SK; Shen, NH; Wu, R1
Chae, YH; el-Bayoumy, K; Hecht, SS; Kurtzke, C; Reddy, B; Rivenson, A; Upadhyaya, P1
Arai, H; Degawa, M; Hashimoto, Y; Matsuda, K1
Leucht, U; Pool-Zobel, BL1
Catterall, F; Clifford, MN; Copeland, E; Ioannides, C1
Belloir, C; Guyonnet, D; Le Bon, AM; Siess, MH; Suschetet, M1
Grover, PL; Hewer, A; Martin, FL; Muir, GH; Phillips, DH; Williams, JA1
Coxhead, JM; Cupid, BC; Garner, RC; Lightfoot, TJ; Nicholson, S1
Fujita, K; Kamataki, T; Muto, S; Yamazaki, Y1
de Boer, JG1
Ambrosone, CB; Fares, M; Gorlewska-Roberts, K; Green, B; Kadlubar, FF1
Cavin, C; Constable, A; Holzhaeuser, D; Huber, WW; Scharf, G; Schilter, B1
Chakraborty, A; Ecker, S; Kassie, F; Knasmüller, S; Lhoste, E; Mohn, G; Uhl, M1
Bader, A; Stahl, F; Wilkening, S1
Cooney, GT; de Boer, JG; Holcroft, J1
He, XY; Hong, JY; Wang, SL1
Cross, AJ; Hayes, RB; Kulldorff, M; Peters, U; Pinsky, PF; Rothman, N; Sinha, R; Weissfeld, JL1
Andriole, GL; Cross, AJ; Hayes, RB; Kirsh, VA; Peters, U; Reding, D; Sinha, R1
Bradley, C; Chandrasekharan, MB; Mernaugh, RL; Parl, FF; Roodi, N; Sun, ZW; van der Meer, R; Yan, H1
Forero, A; Hewitt, R; Luncsford, PJ; Martin, FL1
Jones, KC; Llabjani, V; Martin, FL; Shore, RF; Thomas, GO; Walker, LA1
Chen, G; Douglas, GR; Gingerich, J; Soper, L; White, PA1
Amin, S; El-Bayoumy, K; Geacintov, NE; Kolbanovskiy, A; Kolbanovskiy, M; Kropachev, K; Krzeminski, J; Reeves, D; Yun, BH1
Dobnik, D; Filipič, M; Niderl, MH; Zegura, B1
Chow, WH; Cross, AJ; Daniel, CR; Graubard, BI; Hollenbeck, AR; Park, Y; Rothman, N; Sinha, R; Ward, MH1
Choudhary, S; Sood, S; Wang, HC1
Cross, AJ; Harper, G; Hartman, TJ; Laio, J; Lazarus, P; Lesko, SM; Miller, PE; Muscat, JE; Sinha, R; Zhu, J1
Audebert, M; Cravedi, JP; Debrauwer, L; Douki, T; Jamin, EL; Riu, A; Zalko, D1
Haza, AI; Morales, P1
Pluchino, LA; Wang, HC1
David, R; Ebbels, T; Gooderham, N1
Ferk, F; Filipič, M; Haas, O; Haslinger, E; Huber, WW; Knasmüller, S; Mai, S; Mikulits, W; Mišík, M; Tomc, J; Waldherr, M; Žegura, B1
Breznik, B; Filipič, M; Kamenšek, U; Kološa, K; Tomc, J; Turnšek, TL; Žegura, B1
David, RM; Gooderham, NJ1
Castaño, PR; Linseisen, J; Martínez Góngora, V; Matthes, KL; Rohrmann, S1
David, RM; Gooderham, NJ; Malik, DE1
Chatzi, K; Coke, BA; Coltman, NJ; Hodges, NJ; Lalor, PF; Schulz-Utermoehl, T; Shepherd, EL1

Reviews

3 review(s) available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and benzo(a)pyrene

ArticleYear
Protection by dietary compounds against mutation in a transgenic rodent.
    The Journal of nutrition, 2001, Volume: 131, Issue:11 Suppl

    Topics: Aflatoxin B1; Animals; Animals, Genetically Modified; Bacterial Proteins; Benzo(a)pyrene; Carcinogens; Disease Models, Animal; Escherichia coli Proteins; Humans; Imidazoles; Lac Repressors; Mice; Mutagenesis; Mutagens; Mutation; Neoplasms; Rats; Repressor Proteins; Sex Characteristics; Species Specificity

2001
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Cells, Cultured; Coffee; Colorectal Neoplasms; Disease Models, Animal; Diterpenes; Enzyme Induction; Humans; Imidazoles

2002
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019, Volume: 28, Issue:1

    Topics: Adenoma; Adult; Aged; Amines; Benzo(a)pyrene; Colorectal Neoplasms; Diet; Female; Heterocyclic Compounds; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Odds Ratio; Quinoxalines; Red Meat

2019

Trials

1 trial(s) available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and benzo(a)pyrene

ArticleYear
A prospective study of meat and meat mutagens and prostate cancer risk.
    Cancer research, 2005, Dec-15, Volume: 65, Issue:24

    Topics: Aged; Benzo(a)pyrene; Cooking; Diet; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Prospective Studies; Prostatic Neoplasms; Quinoxalines; Risk Factors; Surveys and Questionnaires

2005

Other Studies

34 other study(ies) available for 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and benzo(a)pyrene

ArticleYear
Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.
    Cancer research, 1990, Jun-01, Volume: 50, Issue:11

    Topics: 2-Acetylaminofluorene; Adolescent; Adult; Aged; Benzo(a)pyrene; Cell Line; Child; Cytochrome P-450 Enzyme System; Food Contamination; Gene Expression; Humans; Hydroxylation; Imidazoles; Microsomes, Liver; Middle Aged; Quinolines; Quinoxalines

1990
Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium.
    Mutation research, 1988, Volume: 201, Issue:1

    Topics: Aflatoxin B1; Aflatoxins; Base Composition; Base Sequence; Benzo(a)pyrene; Carcinogens; Cloning, Molecular; DNA, Bacterial; Food; Histidine; Imidazoles; Molecular Sequence Data; Mutagens; Operon; Quinolines; Salmonella typhimurium

1988
Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats.
    Carcinogenesis, 1995, Volume: 16, Issue:2

    Topics: Animals; Benzo(a)pyrene; Body Weight; Carcinogens; Environmental Pollutants; Female; Imidazoles; Mammary Neoplasms, Experimental; Mutagens; Pyrenes; Rats; Rats, Inbred Strains

1995
Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.
    Journal of biochemistry, 1996, Volume: 120, Issue:3

    Topics: Animals; Base Sequence; Benzo(a)pyrene; beta-Naphthoflavone; Carbolines; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oligonucleotide Probes; p-Aminoazobenzene; Rats; Rats, Inbred F344; Structure-Activity Relationship

1996
Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies.
    Mutation research, 1997, Apr-29, Volume: 375, Issue:2

    Topics: Adult; Aged; Animals; Benzo(a)pyrene; Biopsy; Cells, Cultured; Colon; DNA; DNA Damage; Female; Humans; Hydrogen Peroxide; Imidazoles; Intestinal Mucosa; Lithocholic Acid; Male; Methylnitronitrosoguanidine; Middle Aged; Mutagenicity Tests; Mutagens; Quinolines; Rats; Risk Factors

1997
Contribution of theafulvins to the antimutagenicity of black tea: their mechanism of action.
    Mutagenesis, 1998, Volume: 13, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antimutagenic Agents; Benzo(a)pyrene; Carcinogens; Catechin; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Imidazoles; Male; Microsomes, Liver; N-Nitrosopyrrolidine; Nitrosamines; Oxazines; Phenols; Polyphenols; Quinolines; Rats; Rats, Wistar; Tea; Vitamin K

1998
Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation.
    Mutation research, 2000, Mar-03, Volume: 466, Issue:1

    Topics: Allium; Allyl Compounds; Animals; Benzo(a)pyrene; Cyclophosphamide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Disulfides; Dose-Response Relationship, Drug; Imidazoles; Liver Extracts; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Nitrosamines; Oxidoreductases; Propane; Rats; Rats, Wistar; Subcellular Fractions; Sulfides

2000
Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue.
    Carcinogenesis, 2000, Volume: 21, Issue:9

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; DNA; Gene Expression; Humans; Imidazoles; Male; Organ Culture Techniques; Prostatectomy; Prostatic Hyperplasia; Pyridines; Quinolines; RNA, Messenger

2000
Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and benzo[a]pyrene.
    Mutation research, 2000, Dec-20, Volume: 472, Issue:1-2

    Topics: Aged; Benzo(a)pyrene; Biological Availability; Biotransformation; Breast; Breast Neoplasms; Carbon Radioisotopes; Carcinogens; DNA; DNA Adducts; Female; Humans; Imidazoles; Lymph Nodes; Mass Spectrometry; Middle Aged; Particle Accelerators

2000
Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450.
    Mutation research, 2001, Aug-08, Volume: 479, Issue:1-2

    Topics: Aflatoxin B1; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Beverages; Carcinogens; Catechin; Cell Membrane; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Kinetics; Mixed Function Oxygenases; Mutagenesis; NADPH-Ferrihemoprotein Reductase; Protein Binding; Salmonella typhimurium

2001
Carcinogen-DNA adducts in human breast epithelial cells.
    Environmental and molecular mutagenesis, 2002, Volume: 39, Issue:2-3

    Topics: Adult; Aminobiphenyl Compounds; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; DNA Adducts; DNA Damage; Epithelial Cells; Female; Humans; Imidazoles; Milk, Human

2002
Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells.
    Archives of toxicology, 2003, Volume: 77, Issue:8

    Topics: Animals; Antimutagenic Agents; Benzo(a)pyrene; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Mutagenicity Tests; Mutagens

2003
Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:8

    Topics: 7-Alkoxycoumarin O-Dealkylase; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cell Line, Tumor; Comet Assay; Cytochrome P-450 CYP1A1; Cytoskeleton; Dimethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene Expression; Hepatocytes; Humans; Imidazoles; Inactivation, Metabolic; Liver Neoplasms; Male; Middle Aged; Mutagens; Reverse Transcriptase Polymerase Chain Reaction

2003
The effect of dietary restriction on PhIP-induced mutation in the distal colon and B[a]P- and ENU-induced mutation in the liver of the rat.
    Nutrition and cancer, 2004, Volume: 50, Issue:1

    Topics: Animals; Benzo(a)pyrene; Colon; Diet, Reducing; DNA; Ethylnitrosourea; Female; Imidazoles; Liver; Liver Neoplasms, Experimental; Male; Mutagens; Rats; Rats, Inbred F344; Rats, Mutant Strains; Sex Factors

2004
Human cytochrome p450 2s1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:3

    Topics: Animals; Baculoviridae; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Humans; Imidazoles; Insecta; Nicotiana; Nicotine; Nitrosamines; Oxygenases; Smoke

2005
Meat, meat cooking methods and preservation, and risk for colorectal adenoma.
    Cancer research, 2005, Sep-01, Volume: 65, Issue:17

    Topics: Adenoma; Aged; Benzo(a)pyrene; Carcinogens; Colorectal Neoplasms; Cooking; Diet; Female; Food Preservation; Humans; Imidazoles; Male; Meat; Middle Aged; Mutagens; Quinoxalines

2005
Carcinogen-induced histone alteration in normal human mammary epithelial cells.
    Carcinogenesis, 2007, Volume: 28, Issue:10

    Topics: Aminobiphenyl Compounds; Benzo(a)pyrene; Biotinylation; Breast; Carcinogens; Cells, Cultured; Epithelial Cells; Female; Histones; Humans; Imidazoles; Immunoglobulin Variable Region; Peptide Library; Polychlorinated Dibenzodioxins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2007
Enhanced micronucleus formation and modulation of BCL-2:BAX in MCF-7 cells after exposure to binary mixtures.
    Environmental health perspectives, 2007, Volume: 115 Suppl 1

    Topics: bcl-2-Associated X Protein; Benzo(a)pyrene; Breast Neoplasms; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 Enzyme System; Drug Interactions; Estradiol; Gene Expression Regulation; Hexachlorocyclohexane; Humans; Imidazoles; Micronuclei, Chromosome-Defective; Micronucleus Tests; Proto-Oncogene Proteins c-bcl-2; Xenobiotics

2007
Polybrominated diphenyl ether-associated alterations in cell biochemistry as determined by attenuated total reflection Fourier-transform infrared spectroscopy: a comparison with DNA-reactive and/or endocrine-disrupting agents.
    Environmental science & technology, 2009, May-01, Volume: 43, Issue:9

    Topics: Benzo(a)pyrene; Biochemical Phenomena; Cell Line, Tumor; DNA; Endocrine Disruptors; Halogenated Diphenyl Ethers; Humans; Imidazoles; Principal Component Analysis; Spectroscopy, Fourier Transform Infrared

2009
Induction of lacZ mutations in MutaMouse primary hepatocytes.
    Environmental and molecular mutagenesis, 2010, Volume: 51, Issue:4

    Topics: Aminopyridines; Animals; Benzo(a)pyrene; Cells, Cultured; Cytochrome P-450 Enzyme System; Hepatocytes; Imidazoles; Lac Operon; Mice; Mice, Mutant Strains; Mutagenicity Tests; Mutagens; Mutation

2010
Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene.
    Chemical research in toxicology, 2011, Jan-14, Volume: 24, Issue:1

    Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Chrysenes; Deoxyguanosine; DNA Adducts; DNA Repair; HeLa Cells; Humans; Imidazoles; Mass Spectrometry; Oligonucleotides; Rats

2011
Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells.
    Environmental toxicology and pharmacology, 2011, Volume: 32, Issue:2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antioxidants; Benzo(a)pyrene; Cytoprotection; DNA Damage; Free Radical Scavengers; Hep G2 Cells; Humans; Imidazoles; Microbial Sensitivity Tests; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Quinolines; Rosmarinus; Salmonella typhimurium; tert-Butylhydroperoxide

2011
Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma.
    The American journal of clinical nutrition, 2012, Volume: 95, Issue:1

    Topics: Benzo(a)pyrene; Carcinoma, Renal Cell; Cooking; Diet; Female; Humans; Imidazoles; Incidence; Male; Meat; Middle Aged; Mutagens; Polycyclic Compounds; Prospective Studies; Risk Factors

2012
Dipyridamole intervention of breast cell carcinogenesis.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:3

    Topics: Apoptosis; Benzo(a)pyrene; Blotting, Western; Breast; Breast Neoplasms; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Dipyridamole; DNA Damage; Female; Humans; Imidazoles; MAP Kinase Signaling System; Nitrosamines; Reactive Oxygen Species; Vasodilator Agents

2014
Meat-related compounds and colorectal cancer risk by anatomical subsite.
    Nutrition and cancer, 2013, Volume: 65, Issue:2

    Topics: Aged; Animals; Benzo(a)pyrene; Case-Control Studies; Colonic Neoplasms; Colorectal Neoplasms; Cooking; Feeding Behavior; Female; Humans; Imidazoles; Logistic Models; Male; Meat; Meat Products; Middle Aged; Nitrates; Nitrites; Pennsylvania; Poultry; Quinoxalines; Rectal Neoplasms; Risk Factors; Surveys and Questionnaires

2013
Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Animals; Benzo(a)pyrene; Cell Line; Chromatography, High Pressure Liquid; Colorectal Neoplasms; DNA Adducts; Histones; Humans; Imidazoles; Intestinal Mucosa; Meat; Mice; Mutagenicity Tests; Phosphorylation; Tandem Mass Spectrometry

2013
Spanish honeys protect against food mutagen-induced DNA damage.
    Journal of the science of food and agriculture, 2013, Volume: 93, Issue:12

    Topics: Anticarcinogenic Agents; Benzo(a)pyrene; Cell Survival; Comet Assay; DNA Breaks; DNA Damage; Ericaceae; Food Contamination; Functional Food; Hep G2 Cells; Honey; Humans; Imidazoles; Liver Neoplasms; Models, Biological; Mutagens; N-Nitrosopyrrolidine; Phenols; Rosmarinus; Spain

2013
Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogenesis; Carcinogens; DNA Damage; Drug Synergism; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MCF-7 Cells; NADPH Oxidases; Nitrosamines; ras Proteins; Reactive Oxygen Species; Signal Transduction

2014
Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens.
    Environmental health perspectives, 2016, Volume: 124, Issue:1

    Topics: Benzo(a)pyrene; Carcinogens; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP1A1; DNA Damage; Humans; Imidazoles; Mutation; RNA, Messenger

2016
Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
    Archives of toxicology, 2018, Volume: 92, Issue:2

    Topics: Aflatoxin B1; Benzo(a)pyrene; Cell Line, Tumor; Dimethylnitrosamine; Humans; Hydrogen Peroxide; Imidazoles; Inactivation, Metabolic; Liver; Mutagenicity Tests; Mutagens; Quinolines; Reactive Oxygen Species; Tumor Suppressor Protein p53

2018
Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing.
    Archives of toxicology, 2018, Volume: 92, Issue:5

    Topics: Adipose Tissue; Aflatoxin B1; Benzo(a)pyrene; Cell Differentiation; Cell Line; Comet Assay; Enzymes; Female; Hep G2 Cells; Humans; Imidazoles; Liver; Mesenchymal Stem Cells; Mutagenicity Tests

2018
Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens.
    Archives of toxicology, 2018, Volume: 92, Issue:12

    Topics: Acrylamide; Benzo(a)pyrene; Carcinogens; Carcinogens, Environmental; Cell Line; DNA Damage; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; Food; Humans; Imidazoles; Mutagenesis; Mutagenicity Tests; Mutagens; Mutation

2018
Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells.
    Archives of toxicology, 2019, Volume: 93, Issue:10

    Topics: Benzo(a)pyrene; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cytochrome P-450 CYP1B1; DNA Damage; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Inflammation; Interleukin-6; MCF-7 Cells; MicroRNAs

2019
Application of HepG2/C3A liver spheroids as a model system for genotoxicity studies.
    Toxicology letters, 2021, Jul-01, Volume: 345

    Topics: 4-Nitroquinoline-1-oxide; Activation, Metabolic; Animal Testing Alternatives; Anthracenes; Benzo(a)pyrene; Comet Assay; DNA Damage; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatocytes; Histones; Humans; Imidazoles; Liver; Phosphorylation; Spheroids, Cellular; Time Factors

2021