Page last updated: 2024-08-17

2-acetylaminofluorene and phenobarbital

2-acetylaminofluorene has been researched along with phenobarbital in 137 studies

Research

Studies (137)

Timeframe	Studies, this research(%)	All Research%
pre-1990	103 (75.18)	18.7374
1990's	26 (18.98)	18.2507
2000's	7 (5.11)	29.6817
2010's	1 (0.73)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baus, PR; Ermel, N; Kauffmann, HM; Klein, C; Schrenk, D; Vorderstemann, B	1
Goldfarb, S; Pugh, TD	1
Ito, N; Miyata, Y; Murasaki, G; Nakanishi, K; Shinohara, Y; Tatematsu, M	1
Cameron, RG; Farber, E; Joly, JG; Murray, RK; Sharma, RN	1
Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN	1
Hirose, M; Ito, N; Miyata, Y; Murasaki, G; Nakanishi, K; Tatematsu, M	1
Kitagawa, T; Sugano, H	1
Fukumoto, Y; Noda, K; Okita, K; Takemoto, T	1
Gurkalo, VK; Vlasov, NN	1
Mercier, M; Razzouk, C; Roberfroid, M	1
Watanabe, K; Williams, GM	1
Okuno, S; Seno, T; Takeishi, K	1
Hirose, M; Ito, N; Murasaki, G; Nakanishi, K; Tatematsu, M	1
Koivula, T; Koivusalo, M; Marselos, M; Törrönen, R	1
Emory, TH; Gutmann, HR; Kaplan, E	1
Gronow, M; Lincoln, JC	1
Parke, DV; Poole, TW	1
Felton, JS; Nebert, DW	1
Christopher, JP; Fry, RJ; Peraino, C; Staffeldt, E	2
Bell, P; Gutmann, HR	1
Fry, RJ; Peraino, C; Staffeldt, E	1
Nelson, WL; Thorgeirsson, SS	1
Columbano, A; Coni, P; Curto, M; Faa, G; Giacomini, L; Ledda-Columbano, GM; Sarma, DS	1
Hasegawa, R; Ito, N; Ogawa, K; Wada, S; Yamaguchi, S	1
Hasegawa, R; Imaida, K; Ito, N; Shirai, T; Takahashi, S; Yamaguchi, S	1
Chen, ZY; Eaton, DL	1
Maruyama, H; Tanaka, T; Williams, GM	1
Li, S	1
Saeter, G; Schwarze, PE; Seglen, PO	1
Fukushima, S; Hagiwara, A; Hasegawa, R; Ito, N; Yamada, M	1
Aoki, T; Ito, N; Mutai, M; Tatematsu, M; Wada, S	1
Adams, AK; Del Rio, M; Hanausek-Walaszek, M	1
Hasegawa, R; Ito, N; Kurata, Y; Masuda, A; Shirai, T; Tsuda, H	1
Hasegawa, R; Imaida, K; Ito, N; Mutai, M; Tsuda, H; Yamaguchi, S	1
Decker, RW; Magat, WJ; Malejka-Giganti, D	1
Asamoto, M; Hashimoto, Y; Ito, N; Kato, T; Masuko, T; Nagase, S; Tsuda, H	1
Asamoto, M; de Camargo, JL; Ito, N; Kagawa, M; Nagase, S; Tsuda, H	1
Herren-Freund, SL; Pereira, MA	1
Hoekstra, WG; Laishes, BA; LeBoeuf, RA	1
Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Pirisi, L; Ruggiu, ME	1
Cameron, RG; Farber, E; Hayes, MA; Roberts, E; Safe, SH	1
Davidson, M; Gregg, RG; Wilce, PA	1
de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H	4
Birkett, DJ; Burgess, W; Edwards, AM; Lucas, C; McManus, ME; Stupans, I	1
Daino, L; Donaera, A; Feo, F; Garcea, R; Pascale, R; Pirisi, L	1
Cozzolino, P; Daino, L; Feo, F; Frassetto, S; Garcea, R; Pascale, R; Ruggiu, ME	1
Asamoto, M; Inoue, T; Ito, N; Nagao, M; Ogiso, T; Tsuda, H	1
Bromley, M; Fan, CY; Fida, S; O'Connor, PJ; Saffhill, R	1
Dallner, G; Edlund, C; Ericsson, J	1
Huber, BE; McManus, ME; Minchin, RF; Schwartz, DM; Wirth, PJ	1
Barraud-Hadidane, B; Dirheimer, G; Wund-Bisseret, F	1
Burnet, F; Darby, NJ; Lodola, A	1
Sivak, A; Tu, AS	1
Aström, A; DePierre, JW	1
Hanigan, MH; Pitot, HC	1
Peraino, C; Vesselinovitch, SD	1
Malejka-Giganti, D; Ryzewski, CN	1
Furuya, K; Levine, WG; Mori, H; Numoto, S; Williams, GM	1
Decker, RW; Malejka-Giganti, D; Polovina, MR; Ritter, CL	1
Hayashi, S; McManus, ME; Razzouk, C; Schwartz, D; Thorgeirsson, SS	1
de Gerlache, J; Deleener, A; Kirsch-Volders, M; Lans, M	1
Burnet, FR; Darby, NJ; Lodola, A	2
Fantel, AG; Faustman-Watts, EM; Giachelli, CM; Greenaway, JC; Juchau, MR; Shepard, TH	1
Combes, RD; Walters, JM	1
Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM	1
Katayama, S; Ohmori, T; Williams, GM	1
Capouya, ER; Lindahl, R	1
Sawada, N; Tsukada, H	1
Ito, N; Mera, Y; Moore, MA; Ogiso, T; Tsuda, H	1
Miyauchi, M	1
Becker, FF	2
Ioannides, C; Parke, DV; Parkinson, C	1
Hagiwara, A; Hasegawa, R; Ito, N; Shirai, T; Tatematsu, M; Tsuda, H	1
Ali, B; Kaur, S	1
Altanerová, V	1
Balis, ME; Dizik, M; Wainfan, E	1
Carubelli, R; Donaldson, SG; Fox, OF; Griffin, MJ	1
Maeura, Y; Williams, GM	1
Furuya, K; Mori, H; Williams, GM	1
Furuya, K; Williams, GM	1
Bannasch, P; Ito, N; Moore, MA	1
Aström, A; Balk, L; DePierre, JW; Meijer, J; Morgenstern, R; Seidegård, J	1
Chessebeuf, M; Exilie-Frigere, MF; Padieu, P; Wood, G	1
de Gerlache, J; Lans, M; Préat, V; Roberfroid, MB; Taper, HS	1
Peraino, C; Stevens, FJ	2
McManus, ME; Minchin, RF; Sanderson, N; Thorgeirsson, SS; Wirth, PJ	1
Fukushima, S; Ito, N; Nakanishi, K; Shirai, T	1
Lu, AY; Miwa, GT; West, SB; Wislocki, PG	1
Fukushima, S; Hagiwara, A; Ito, N; Nakanishi, K; Tamano, S	1
Kunz, W; Schaude, G; Schwarz, M; Tennekes, H	1
Smith, CL; Staiano, N; Thorgeirsson, SS; Wirth, PJ	1
Bentley, P; Germann, M; Oesch, F; Stäubli, W; Waechter, F	1
Evces, S; Lindahl, R; Sheng, WL	1
Allen, B; Lindahl, R	1
Batardy-Grégoire, M; Razzouk, C; Roberfroid, M	1
Lindahl, R	1
Hiraga, K; Kawano, S; Kojima, A	1
Gurkalo, VK	1
Bradshaw, TK; Freedman, RB; Kaderbhai, MA	2
Kayano, T; Kitagawa, T; Sugano, H; Watanabe, R	1
Mori, H; Nishikawa, A; Takahashi, M; Tanaka, T; Williams, GM	1
Peraino, C	1
Lenk, W; Scharmer, U	1
Ishii, K; Kamataki, T; Kato, R; Yamaguchi, N; Yamazoe, Y	1
Fry, RJ; Haugen, DA; Lombard, LS; Peraino, C; Staffeldt, EF; Stevens, FJ	1
Hasegawa, R; Imaida, K; Ito, N; Takano, T; Tatematsu, M	1
Daino, L; De Miglio, MR; Feo, F; Gaspa, L; Nufris, A; Pascale, R; Seddaiu, MA; Simile, MM	1
Hammerl, R; Kirchner, T; Neumann, HG	1
Leibold, E; Schwarz, LR	1
Castelain, P; Ghahroudi, MA; Kirsch-Volders, M; Van Goethem, F	1
Duffel, MW; Howell, BA; Kosanke, SD; Norton, TR; Ringer, DP; Woulfe, GW	1
Lenk, W; Rosenbauer-Thilmann, R	1
Asamoto, M; Baba-Toriyama, H; Ito, N; Kato, T; Kim, DJ; Mutai, M; Ozaki, K; Tsuda, H; Wada, S; Yamaguchi, S	1
Galloway, SM; Johnson, TE; Umbenhauer, DR	1
Mori, H; Okumura, A; Tanaka, T	1
Berges, R; Chaumontet, C; Heberden, C; Honikman-Leban, E; Krutovskikh, VA; Le Bon, AM; Martel, P; Shahin, MM; Suschetet, M; Yamasaki, H	1
Fung, KY; Krewski, D; Lutz, WK; Shephard, S; Zhu, Y	1
Eriksson, LC; Rissler, P; Torndal, UB	1
Downing, J; McClain, RM; Montandon, F; Steward, RE; Verna, LK; Whysner, J; Williams, GM	1
Kauffmann, HM; Schrenk, D	1
Barbisan, LF; de Camargo, JL; Kaneno, R; Ribeiro, LR; Rocha, NS; Rodrigues, MA; Salvadori, DM; Spinardi, AL	1
Bitsch, A; Duebelbeiss, C; Greiner, A	1
Barbisan, LF; Fávero Salvadori, DM; Kaneno, R; Marchesan Rodrigues, MA; Spinardi-Barbisan, AL; Trindade Moreira, EL; Viana de Camargo, JL	1
Finch, RA; Fort, DJ; Rogers, RL; Stover, EL	1
Ahr, HJ; Duan, JD; Enzmann, HH; Jeffrey, AM; Perrone, CE; Schmidt, U; Williams, GM	1
Groos, J; Kopp-Schneider, A	1
Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M	1
Ando, Y; Kiyosawa, N; Manabe, S; Niino, N; Watanabe, K; Yamoto, T	1
Barbisan, LF; de Camargo, JL; de Oliveira, ML; Franchi, CA; Ribeiro, LR; Rocha, NS; Salvadori, DM; Solano, ML; Spinardi-Barbisan, AL	1

Reviews

3 review(s) available for 2-acetylaminofluorene and phenobarbital

Article	Year
Single-hit versus multi-hit concept of hepatocarcinogenesis. Carcinogenesis; a comprehensive survey, 1985, Volume: 10 Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Phenobarbital; Rats	1985
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications. Carcinogenesis; a comprehensive survey, 1982, Volume: 7 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Hypertrophy; Liver; Liver Neoplasms; Microsomes, Liver; Neoplasms, Experimental; Organ Size; Oxygenases; Phenobarbital; Precancerous Conditions; Rats	1982
Statistical analysis of the lacI transgenic mouse mutagenicity assay. Mutation research, 1997, Mar-04, Volume: 374, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Bacterial Proteins; Computer Simulation; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Escherichia coli Proteins; Heptachlor; Lac Repressors; Liver; Mice; Mice, Transgenic; Models, Genetic; Mutagenicity Tests; Phenobarbital; Repressor Proteins; Urinary Bladder	1997

Other Studies

134 other study(ies) available for 2-acetylaminofluorene and phenobarbital

Article	Year
Up-regulation of transporters of the MRP family by drugs and toxins. Toxicology letters, 2001, Mar-31, Volume: 120, Issue:1-3 Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carrier Proteins; Gene Expression Regulation; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Toxins, Biological; Up-Regulation	2001
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital. Cancer research, 1978, Volume: 38, Issue:12 Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hyperplasia; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Thymidine	1978
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals. Gan, 1979, Volume: 70, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlorocyclohexane; Hyperplasia; Liver; Liver Diseases; Male; Phenobarbital; Rats	1979
Multiple patterns of induction of rat liver microsomal mono-oxygenases and other polypeptides by xenobiotics [proceedings]. Biochemical Society transactions, 1979, Volume: 7, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone; Rats; Safrole	1979
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. The Biochemical journal, 1979, Aug-15, Volume: 182, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole	1979
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats. Journal of the National Cancer Institute, 1979, Volume: 63, Issue:6 Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Precancerous Conditions; Rats; Rats, Inbred F344	1979
Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats. Gan, 1977, Volume: 68, Issue:2 Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Drug Synergism; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Phenobarbital; Rats	1977
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. Gan, 1976, Volume: 67, Issue:6 Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplasia; Liver; Liver Neoplasms; Male; Microsomes, Liver; Phenobarbital; Rats	1976
[Effect of different classes of modifying factors on experimental hepatic carcinogenesis]. Vestnik Akademii meditsinskikh nauk SSSR, 1979, Issue:12 Topics: 2-Acetylaminofluorene; Alkanesulfonates; Animals; Antimetabolites, Antineoplastic; Cytochrome P-450 Enzyme System; Enzyme Activation; Free Radicals; Liver Neoplasms; Male; Mitochondria, Liver; Monoamine Oxidase; Neoplasms, Experimental; Oxidation-Reduction; Phenobarbital; Rats; Time Factors	1979
Specific modification of the properties of the N-hydroxylase. Relationship with carcinogenesis by aromatic amides. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1978, Issue:1 Topics: 2-Acetylaminofluorene; Amides; Aminobiphenyl Compounds; Animals; Carcinogens; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats	1978
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions. Journal of the National Cancer Institute, 1978, Volume: 61, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors	1978
Differential effect of a microsomal deacetylase inhibition on the mutagenicity in Salmonella typhimurium of 2-acetylaminofluorene by liver homogenates of guinea pigs, mice and rats. Cancer letters, 1979, Volume: 6, Issue:1 Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Benzoflavones; Guinea Pigs; Mice; Microsomes, Liver; Mutagens; Paraoxon; Phenobarbital; Rats; Salmonella typhimurium	1979
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats. Gan, 1978, Volume: 69, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neoplasms; Male; Naphthalenes; Neoplasms, Experimental; Oxazoles; Phenobarbital; Polychlorinated Biphenyls; Precancerous Conditions; Rats	1978
Comparison of phenobarbital- and carcinogen-induced aldehyde dehydrogenases in the rat. Biochimica et biophysica acta, 1979, Feb-19, Volume: 583, Issue:1 Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Benzopyrenes; Carcinogens; Chrysenes; Cytoplasm; Enzyme Induction; Female; Intestinal Mucosa; Liver; Methylcholanthrene; Mitochondria; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Urethane	1979
Microsomal metabolism of arylamides by the rat and guinea pig--I. Oxidation of N-3-fluorenylacetamide at carbon-atom-9--a major metabolic reaction. Biochemical pharmacology, 1978, Volume: 27, Issue:11 Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Fluorenes; Guinea Pigs; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats	1978
The binding of 14C-labelled acetylaminofluorene to nuclear proteins and DNA. Cancer letters, 1978, Volume: 5, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Chromosomal Proteins, Non-Histone; DNA; Fluorenes; Histones; Liver; Male; Nucleoproteins; Phenobarbital; Rats; Sulfates; Time Factors	1978
Effects of age, inducing agents and carcinogens on the distribution of cytochrome P-450 in microsomal membranes from rat liver. Biochemical Society transactions, 1978, Volume: 6, Issue:5 Topics: 2-Acetylaminofluorene; Aging; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrum Analysis	1978
Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. The Journal of biological chemistry, 1975, Sep-10, Volume: 250, Issue:17 Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Crosses, Genetic; Cytochrome P-450 Enzyme System; Female; Genes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Mutagens; Oxygenases; Phenobarbital; Species Specificity	1975
Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Food and cosmetics toxicology, 1977, Volume: 15, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Cresols; Diet; DNA; Drug Synergism; Fluorenes; Liver; Liver Neoplasms; Male; Organ Size; Phenobarbital; Rats; Time Factors	1977
N-Hydroxylation of arylamides by the rat and guinea pig. Evidence for substrate specificity and participation of cytochrome P1-450. Biochimica et biophysica acta, 1977, Jun-23, Volume: 498, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Bile; Cobalt; Cytochrome P-450 Enzyme System; Female; Fluorenes; Fluorides; Guinea Pigs; Hydroxyacetylaminofluorene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet	1977
Effects of varying the onset and duration of exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis. Cancer research, 1977, Volume: 37, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Time Factors	1977
Separation and quantitative determination of 2-acetyl-aminofluorene and its hydroxylated metabolites by high pressure liquid chromatography. Analytical biochemistry, 1976, Volume: 75, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Chromatography, High Pressure Liquid; Fluorenes; Hydroxylation; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Structure-Activity Relationship	1976
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat. Cancer research, 1975, Volume: 35, Issue:10 Topics: 2-Acetylaminofluorene; Amobarbital; Animals; DDT; DNA, Neoplasm; Drug Synergism; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenytoin; Rats	1975
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis. Carcinogenesis, 1992, Volume: 13, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Glutamyltransferase; Hyperplasia; Lead; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Nitrates; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains	1992
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis. Teratogenesis, carcinogenesis, and mutagenesis, 1991, Volume: 11, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Glutathione Transferase; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Diseases; Liver Neoplasms, Experimental; Liver Regeneration; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1991
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine. Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:3 Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1991
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats. Toxicology and applied pharmacology, 1991, Volume: 111, Issue:1 Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Hepatectomy; Hyperplasia; Liver; Male; Oxazines; Phenobarbital; Rats; Rats, Inbred F344; Stimulation, Chemical	1991
Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital. Toxicologic pathology, 1990, Volume: 18, Issue:2 Topics: 2-Acetylaminofluorene; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Cell Transformation, Neoplastic; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Histocytochemistry; Liver; Liver Neoplasms; Male; Microbodies; Phenobarbital; Phthalic Acids; Rats; Rats, Inbred F344	1990
[Expression of cellular oncogenes during hepatocarcinogenesis in rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1990, Volume: 12, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains	1990
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas. Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; Liver Neoplasms; Liver Neoplasms, Experimental; Liver Regeneration; Male; Neoplasm Transplantation; Phenobarbital; Rats; Rats, Inbred WKY	1990
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats. Cancer letters, 1990, Oct-08, Volume: 54, Issue:1-2 Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione Transferase; Liver; Male; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Inbred F344	1990
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development. Cancer letters, 1990, Volume: 49, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1990
Structural and immunological identity of p65 tumor-associated factors from rat and mouse hepatocarcinomas. Progress in clinical and biological research, 1990, Volume: 331 Topics: 2-Acetylaminofluorene; Animals; Antibodies, Neoplasm; Biomarkers, Tumor; Carrier Proteins; Cocarcinogenesis; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms, Experimental; Mice; Neoplasm Proteins; Nucleocytoplasmic Transport Proteins; Phenobarbital; Rats; Rats, Inbred ACI; Rats, Inbred BUF; Rats, Inbred Strains; Species Specificity; Transcription Factor RelA; Tumor Cells, Cultured	1990
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens. Cancer letters, 1986, Volume: 32, Issue:1 Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors	1986
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver. Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Synergism; Glutathione Transferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344; Thioacetamide	1989
Modifications of hepatic microsomal 9-oxidation of N-2-fluorenylacetamide in response to gonadectomy and treatment of rats with phenobarbital or diethylnitrosamine. Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Castration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Female; Glucuronidase; Glucuronosyltransferase; Hydroxylation; Male; Microsomes, Liver; NADH Dehydrogenase; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains	1989
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital. Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:11 Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Immunohistochemistry; Isoenzymes; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity	1989
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development. Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Disease Susceptibility; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred Strains; Species Specificity	1989
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model. Cancer letters, 1985, Volume: 27, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains	1985
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats. Cancer research, 1985, Volume: 45, Issue:11 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Selenium	1985
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool. Carcinogenesis, 1985, Volume: 6, Issue:12 Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kinetics; Liver; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Polyamines; Putrescine; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Spermidine; Spermine	1985
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver. Journal of the National Cancer Institute, 1986, Volume: 76, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Cell Survival; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred F344	1986
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats. The International journal of biochemistry, 1986, Volume: 18, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxymethylglutaryl CoA Reductases; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains	1986
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:7 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; Propionates; Rats; Rats, Inbred Strains	1986
Effect of dexamethasone on cytochrome P-450 mediated metabolism of 2-acetylaminofluorene in cultured rat hepatocytes. Biochemical pharmacology, 1987, Jan-15, Volume: 36, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Corticosterone; Cytochrome P-450 Enzyme System; Dexamethasone; Hydrocortisone; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Tyrosine Transaminase	1987
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis. Toxicologic pathology, 1987, Volume: 15, Issue:1 Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Male; Ornithine Decarboxylase; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Thionucleosides	1987
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis. Toxicologic pathology, 1987, Volume: 15, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains	1987
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion. Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:6 Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Hepatectomy; Liver Neoplasms, Experimental; Methyldimethylaminoazobenzene; Mutagens; Phenobarbital; Quinolines; Rats; Rats, Inbred F344; Thyroid Neoplasms	1988
Phenobarbital: a non-genotoxic agent which induces the repair of O6-methylguanine from hepatic DNA. Carcinogenesis, 1988, Volume: 9, Issue:11 Topics: 2-Acetylaminofluorene; Animals; DNA Repair; Guanine; Liver; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenobarbital; Rats; Thymine	1988
Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny. Chemico-biological interactions, 1987, Volume: 62, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Cell Compartmentation; Cholestyramine Resin; Cytochrome P-450 Enzyme System; Diethylamines; Diterpenes; Dolichol Phosphates; Dolichols; Hexosyltransferases; Liver; Liver Regeneration; Methylcholanthrene; Microbodies; Microsomes, Liver; NADH Dehydrogenase; Phenobarbital; Phthalic Acids; Polyisoprenyl Phosphates; Rats; Turpentine	1987
Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450. Biochemical and biophysical research communications, 1986, May-29, Volume: 137, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Aroclors; Cell Line; Chlorodiphenyl (54% Chlorine); Cloning, Molecular; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver Neoplasms, Experimental; Mixed Function Oxygenases; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Rats; RNA, Messenger	1986
In vivo covalent binding of aminofluorene derivatives to mitochondrial liver DNA of rats pretreated with phenobarbital. Toxicology letters, 1986, Volume: 32, Issue:3 Topics: 2-Acetylaminofluorene; Animals; DNA, Mitochondrial; Injections, Intraperitoneal; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1986
Testosterone metabolite profiles reveal differences in the spectrum of cytochrome P-450 isozymes induced by phenobarbitone, 2-acetylaminofluorene and 3-methylcholanthrene in the chick embryo liver. Biochemical pharmacology, 1986, Nov-15, Volume: 35, Issue:22 Topics: 2-Acetylaminofluorene; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; In Vitro Techniques; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Testosterone	1986
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis. Carcinogenesis, 1987, Volume: 8, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liver Neoplasms; Liver Neoplasms, Experimental; Phenobarbital; Rats	1987
Use of rodent hepatocytes for metabolic activation in transformation assays. IARC scientific publications, 1985, Volume: 67 Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Liver; Methylcholanthrene; Mice; Phenobarbital; Rats; Species Specificity	1985
Identification of the forms of cytochrome P-450 induced in rat liver by 2-acetylaminofluorene using immunoblotting and partial purification. Biochemical and biophysical research communications, 1985, Apr-30, Volume: 128, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunosorbent Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1985
Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital. Cancer research, 1985, Volume: 45, Issue:12 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Female; Liver; Liver Transplantation; Male; Phenobarbital; Precancerous Conditions; Rats; Time Factors	1985
Microsomal metabolism of the carcinogen, N-2-fluorenyl-acetamide, by the mammary gland and liver of female rats. II. Glucuronidation of ring- and N-hydroxylated metabolites of N-2-fluorenylacetamide. Carcinogenesis, 1985, Volume: 6, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Carbon Radioisotopes; Female; Glucuronates; Glucuronosyltransferase; Hydroxylation; In Vitro Techniques; Lactation; Mammary Glands, Animal; Microsomes; Microsomes, Liver; Nitrophenols; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains	1985
Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide. Toxicology and applied pharmacology, 1985, Volume: 77, Issue:1 Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Carcinogens; Drug Synergism; Liver Neoplasms; Male; Nafenopin; Neoplasms, Experimental; Phenobarbital; Propionates; Rats; Rats, Inbred F344	1985
Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide. Carcinogenesis, 1985, Volume: 6, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Female; Hydroxylation; In Vitro Techniques; Lactation; Mammary Glands, Animal; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains	1985
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines. Biochemical pharmacology, 1985, May-01, Volume: 34, Issue:9 Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Enzyme Induction; Epoxide Hydrolases; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes	1985
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats. Cancer genetics and cytogenetics, 1985, Volume: 17, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Histocytochemistry; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains	1985
A study into the effects of 2-acetylaminofluorene on hepatic monooxygenase activities in the chick embryo. Biochemical pharmacology, 1985, Aug-01, Volume: 34, Issue:15 Topics: 2-Acetylaminofluorene; Acetylation; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Hydroxylation; Liver; Methylcholanthrene; Oxygenases; Phenobarbital	1985
Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis. Toxicology and applied pharmacology, 1985, Volume: 80, Issue:1 Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Cyclophosphamide; Embryo, Mammalian; Female; Male; Methylcholanthrene; Microsomes, Liver; Organ Culture Techniques; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Teratogens	1985
Characterization of a microsomal fraction from rat small intestine for metabolic activation of some promutagens. Carcinogenesis, 1985, Volume: 6, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Fluorenes; Intestine, Small; Male; Microsomes; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Phenobarbital; Proadifen; Rats	1985
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers. Toxicology and applied pharmacology, 1985, Volume: 81, Issue:3 Pt 1 Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole	1985
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects. Carcinogenesis, 1981, Volume: 2, Issue:11 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344	1981
Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis. Journal of the National Cancer Institute, 1983, Volume: 70, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; gamma-Glutamyltransferase; Histocytochemistry; Liver Neoplasms, Experimental; Phenobarbital; Rats; Stimulation, Chemical	1983
Promotion of chemically initiated hepatocarcinogenesis. Progress in clinical and biological research, 1982, Volume: 109 Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Humans; Liver; Liver Neoplasms; Male; Models, Biological; Neoplasms, Experimental; Phenobarbital; Phenotype; Rats	1982
Effects of phenobarbital-feeding on the phalloidin-sensitivity of rat hepatocytes. Gan, 1983, Volume: 74, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Cell Membrane; gamma-Glutamyltransferase; Liver; Male; Oligopeptides; Phalloidine; Phenobarbital; Rats; Rats, Inbred F344; Time Factors	1983
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions. Cancer letters, 1984, Volume: 25, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Phenobarbital; Phenotype; Rats; Rats, Inbred F344; Stimulation, Chemical; Time Factors	1984
Conversion of procarcinogens to mutagens by the S-9 fraction from the liver of rainbow trout (Salmo gairdneri): inducibility with PCB, 3-methylcholanthrene and phenobarbital and inhibition by metyrapone and alpha-naphthoflavone. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Benzo(a)pyrene; Benzoflavones; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mutagenicity Tests; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonidae; Subcellular Fractions; Temperature; Trout	1984
The direct and indirect effects of promoters may depend upon the nature of the initiated cell. Princess Takamatsu symposia, 1983, Volume: 14 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; Mice; Phenobarbital	1983
Comparison of different models of rat liver carcinogenesis: conclusions from a systemic analysis. Toxicologic pathology, 1984, Volume: 12, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Diet; gamma-Glutamyltransferase; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains	1984
Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448. Xenobiotica; the fate of foreign compounds in biological systems, 1981, Volume: 11, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Female; Guinea Pigs; Male; Mesocricetus; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains	1981
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide. Gan, 1982, Volume: 73, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344	1982
The effects of phenobarbital, 3-methylcholanthrene and benzo(a)pyrene on the hydrolysis of xenobiotics in the rat. Biochemical pharmacology, 1983, Nov-15, Volume: 32, Issue:22 Topics: 2-Acetylaminofluorene; Acetanilides; Amidohydrolases; Animals; Aspirin; Benzo(a)pyrene; Benzopyrenes; Carboxylic Ester Hydrolases; Female; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Procaine; Rats; Tissue Distribution	1983
Infectivity of avian myelocytomatosis virus MC29 in rats. Neoplasma, 1983, Volume: 30, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Avian Leukosis Virus; Chickens; Hepatectomy; Liver; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred Strains; Spleen; Virus Cultivation	1983
Increased activity of rat liver N2-guanine tRNA methyltransferase II in response to liver damage. Biochimica et biophysica acta, 1984, Jun-29, Volume: 799, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Escherichia coli; Ethionine; Female; Hepatectomy; Hot Temperature; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Transfer, Amino Acyl; RNA, Transfer, Met; tRNA Methyltransferases	1984
Changes in the relative distribution and properties of smooth endoplasmic reticulum subfractions isolated from the livers of rats fed 2-acetylaminofluorene. Cancer letters, 1984, Volume: 24, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Endoplasmic Reticulum; Liver; Liver Regeneration; Male; Manganese; Phenobarbital; Rats; Rats, Inbred Strains	1984
Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Diet; Dose-Response Relationship, Drug; Drug Synergism; Lung Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344	1984
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide. Toxicology and applied pharmacology, 1983, Volume: 70, Issue:1 Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Liver Neoplasms, Experimental; Male; Methapyrilene; Phenobarbital; Rats; Rats, Inbred F344	1983
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide. Carcinogenesis, 1984, Volume: 5, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344	1984
The induction of cytochrome P-450 and monooxygenase activities in the chick embryo by 2-acetylaminofluorene. Biochemical and biophysical research communications, 1984, Feb-29, Volume: 119, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Epoxide Hydrolases; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital	1984
Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4,4'-diaminodiphenylmethane: a sequential histological and histochemical analysis. Carcinogenesis, 1984, Volume: 5, Issue:3 Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Carcinogens; Drug Interactions; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains	1984
Induction of xenobiotic-metabolizing enzymes by trans-stilbene oxide and 2-acetylaminofluorene: observations on enzyme induction by drugs. Biochemical Society transactions, 1984, Volume: 12, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Enzymes; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Stilbenes	1984
Interactions of caffeine and phenobarbital on sister chromatid exchanges in rat liver epithelial cell lines treated with 2-acetyl-aminofluorene and N-acetoxy-2-acetylaminofluorene. Cell biology international reports, 1984, Volume: 8, Issue:4 Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Caffeine; Cell Line; Cells, Cultured; Crossing Over, Genetic; Epithelial Cells; Epithelium; Liver; Metaphase; Phenobarbital; Rats; Sister Chromatid Exchange	1984
Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis. Carcinogenesis, 1983, Volume: 4, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains	1983
Liver as a model system for analyzing mechanisms of tumor initiation and promotion. Basic life sciences, 1983, Volume: 24 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Drug Evaluation, Preclinical; Liver Neoplasms; Mice; Neoplasms, Experimental; Phenobarbital	1983
Kinetics of N- and C-hydroxylations of 2-acetylaminofluorene in male Sprague-Dawley rat liver microsomes: implications for carcinogenesis. Cancer research, 1983, Volume: 43, Issue:8 Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains	1983
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. Environmental health perspectives, 1983, Volume: 50 Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationship, Drug; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Membrane Potentials; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Saccharin; Urinary Bladder Neoplasms	1983
Activating enzymes: multiple monooxygenase forms with different substrate preferences as related to toxic effects. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 3 Topics: 2-Acetylaminofluorene; Animals; Benzopyrenes; Carcinogens; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Humans; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Oxygenases; Phenobarbital; Rabbits; Rats; Species Specificity; Stereoisomerism; Substrate Specificity	1980
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats. Journal of the National Cancer Institute, 1982, Volume: 68, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver Neoplasms, Experimental; Male; Neoplasms, Experimental; Organ Specificity; Phenobarbital; Rats; Rats, Inbred F344; Saccharin; Urinary Bladder; Urinary Bladder Neoplasms	1982
Metabolic activation of 2-acetylaminofluorene. Advances in experimental medicine and biology, 1981, Volume: 136 Pt B Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Biotransformation; Kinetics; Liver; Male; Microsomes, Liver; Mutagenicity Tests; Mutation; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sulfotransferases; Sulfurtransferases	1981
Immuno-electron-microscopic studies on the subcellular distribution of rat liver epoxide hydrolase and the effect of phenobarbitone and 2-acetamidofluorene treatment. The Biochemical journal, 1982, Mar-15, Volume: 202, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Epoxide Hydrolases; Ferritins; Immunoenzyme Techniques; Liver; Male; Microscopy, Electron; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Subcellular Fractions	1982
Expression of the tumor aldehyde dehydrogenase phenotype during 2-acetylaminofluorene-induced rat hepatocarcinogenesis. Cancer research, 1982, Volume: 42, Issue:2 Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Cell Transformation, Neoplastic; Electrophoresis, Polyacrylamide Gel; Isoelectric Focusing; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Rats; Rats, Inbred Strains	1982
Development of a model to simulate the characteristics of rat liver tumor promotion by phenobarbital. Carcinogenesis; a comprehensive survey, 1982, Volume: 7 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Liver Neoplasms; Mathematics; Models, Biological; Neoplasms, Experimental; Phenobarbital; Rats	1982
Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase during rat hepatocarcinogenesis. Carcinogenesis, 1982, Volume: 3, Issue:5 Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Cocarcinogenesis; Drug Administration Schedule; Enzyme Induction; Liver; Liver Neoplasms; Male; Phenobarbital; Phenotype; Rats; Rats, Inbred Strains	1982
Induction and modification of rat liver microsomal arylamide N-hydroxylase by various pretreatments. Molecular pharmacology, 1982, Volume: 21, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Biotransformation; Chromatography, Gas; Enzyme Induction; Fluorenes; In Vitro Techniques; Male; Microsomes, Liver; p-Aminohippuric Acid; Phenobarbital; Rats; Rats, Inbred Strains	1982
Morphological classification of mouse liver tumors based on biological characteristics. Cancer research, 1982, Volume: 42, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chlordan; Liver Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phenobarbital; Species Specificity	1982
Induction of aldehyde dehydrogenases during hepatocarcinogenesis. Progress in clinical and biological research, 1982, Volume: 114 Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine; Enzyme Induction; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Phenotype; Precancerous Conditions; Rats	1982
The suppressive effect of hepatic 9,000 x G supernatant fraction from 3-methylcholanthrene-treated rats on the mutagenic activity of 2-acetylaminofluorene. Japanese journal of pharmacology, 1980, Volume: 30, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Drug Synergism; Flavonoids; Liver; Male; Methylcholanthrene; Mutagens; Phenobarbital; Rats; Subcellular Fractions	1980
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine. Neoplasma, 1980, Volume: 27, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Sympathetic Nervous System; Synapses	1980
Specific labelling of microsomal proteins by reactive intermediates generated from 2-acetylaminofluorene in vitro. Chemico-biological interactions, 1981, Volume: 36, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains	1981
In vitro carcinogenesis of hepatocytes obtained from acetylaminofluorene-treated rat liver and promotion of their growth by phenobarbital. Gan, 1980, Volume: 71, Issue:6 Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Drug Synergism; Epithelium; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats	1980
Enhancing effect of barbital on N-2-fluorenylacetamide-induced rat liver lesions. Gan, 1981, Volume: 72, Issue:5 Topics: 2-Acetylaminofluorene; Animals; Barbital; Barbiturates; Body Weight; Kinetics; Liver; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred ACI	1981
Initiation and promotion of liver tumorigenesis. National Cancer Institute monograph, 1981, Issue:58 Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Phenobarbital; Rats	1981
Reactive intermediates of 2-acetylaminofluorene metabolism in vitro covalently label specific rat liver microsomal proteins. Advances in experimental medicine and biology, 1981, Volume: 136 Pt B Topics: 2-Acetylaminofluorene; Animals; Carbon Radioisotopes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats	1981
Reaction of microsomal and cytosolic enzymes with N-arylacetohydroxamic acids in the presence of oxygen. Advances in experimental medicine and biology, 1981, Volume: 136 Pt B Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Biotransformation; Cytosol; Hydroxamic Acids; Kinetics; Liver; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Rabbits; Rats	1981
Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes. Biochemical pharmacology, 1980, Aug-15, Volume: 29, Issue:16 Topics: 2-Acetylaminofluorene; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rabbits; Rats; Species Specificity	1980
Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis. Cancer research, 1980, Volume: 40, Issue:9 Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Time Factors	1980
Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride. Gan, 1980, Volume: 71, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Drug Synergism; Hyperplasia; Liver; Male; Phenobarbital; Rats	1980
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis. Cancer letters, 1994, Apr-29, Volume: 79, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, ras; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar; Regression Analysis; RNA, Messenger; S-Adenosylmethionine; Time Factors; Transcription, Genetic	1994
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation. Chemico-biological interactions, 1994, Volume: 93, Issue:1 Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma-Glutamyltransferase; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar; Sex Factors; Stilbenes; Time Factors	1994
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes. Carcinogenesis, 1993, Volume: 14, Issue:10 Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar	1993
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis. Carcinogenesis, 1993, Volume: 14, Issue:11 Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitotic Index; Phenobarbital; Rats; Rats, Wistar	1993
Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis. Molecular carcinogenesis, 1994, Volume: 9, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Cytosol; Down-Regulation; Hydroxyacetylaminofluorene; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Sprague-Dawley	1994
Metabolism of 2-acetylaminofluorene. I. Metabolism in vitro of 2-acetylaminofluorene and 2-acetylaminofluoren-9-one by hepatic enzymes. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cytosol; Female; Hydroxylation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Stimulation, Chemical	1993
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver. Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:3 Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deoxycholic Acid; Ethinyl Estradiol; Glutathione Transferase; Injections, Intraperitoneal; Liver; Liver Cirrhosis, Experimental; Liver Diseases; Male; Organ Size; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred F344; Swine	1996
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9. Environmental and molecular mutagenesis, 1996, Volume: 28, Issue:1 Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats	1996
Simultaneous measurement of unscheduled and replicating DNA synthesis by means of a new cell culture insert DNA retention method: rapid induction of replicating DNA synthesis in response to genotoxic carcinogens. Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:8 Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Autoradiography; Carcinogens; Cells, Cultured; Diethylnitrosamine; DNA; DNA Replication; Hydroxyurea; Liver; Male; Mutagens; Nafenopin; Phenobarbital; Rats; Scintillation Counting	1996
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication. Nutrition and cancer, 1996, Volume: 26, Issue:3 Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavones; Flavonoids; Gap Junctions; Glutathione Transferase; Hepatectomy; Liver Neoplasms; Male; Phenobarbital; Precancerous Conditions; Quercetin; Rats; Rats, Wistar	1996
Induced drug resistance inhibits selection of initiated cells and cancer development. Carcinogenesis, 1997, Volume: 18, Issue:4 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Liver; Liver Regeneration; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Wistar	1997
Absence of DNA adduct formation by phenobarbital, polychlorinated biphenyls, and chlordane in mouse liver using the 32P-postlabeling assay. Toxicology and applied pharmacology, 1998, Volume: 148, Issue:1 Topics: 2-Acetylaminofluorene; Animals; Benzidines; Carcinogens; Chlordan; Chromatography, Thin Layer; DNA; DNA Adducts; Female; Insecticides; Liver; Male; Mice; Organ Size; Phenobarbital; Phosphorus Radioisotopes; Polychlorinated Biphenyls	1998
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene. Biochemical and biophysical research communications, 1998, Apr-17, Volume: 245, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Cloning, Molecular; Ethinyl Estradiol; Gene Expression Regulation, Neoplastic; Genes, MDR; Genes, Reporter; Phenobarbital; Rats; RNA, Messenger; Sequence Analysis, DNA; Transfection; Tumor Cells, Cultured	1998
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis. Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:1 Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Cytotoxicity, Immunologic; Killer Cells, Natural; Liver Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Precancerous Conditions; Rats; Rats, Wistar	1999
c-fos gene expression in rat liver is induced by phenobarbital. Cancer letters, 1999, Jan-29, Volume: 135, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Gene Expression; Genes, fos; Liver; Liver Neoplasms, Experimental; Phenobarbital; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Stilbenes	1999
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats. Cancer letters, 2000, Jun-30, Volume: 154, Issue:2 Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; Concanavalin A; Diethylnitrosamine; Flow Cytometry; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Spleen; T-Lymphocyte Subsets; Tissue Distribution	2000
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures. Drug and chemical toxicology, 2001, Volume: 24, Issue:2 Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); Coumarins; Cyclophosphamide; Embryo, Mammalian; Embryo, Nonmammalian; Isoniazid; Microsomes, Liver; Phenobarbital; Rats; Toxicity Tests; Trichloroethylene; Xenopus laevis	2001
Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens. Archives of toxicology, 2004, Volume: 78, Issue:10 Topics: 2-Acetylaminofluorene; Animal Testing Alternatives; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Enzymes; Female; Liver; Methylcholanthrene; Methylenebis(chloroaniline); Phenobarbital; Phosphorus Radioisotopes; Quinoxalines; Rats; Rats, Inbred F344; Rats, Wistar; Turkey	2004
Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment. Mathematical biosciences, 2006, Volume: 202, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Glutathione S-Transferase pi; Hepatocytes; Histocytochemistry; Liver Neoplasms, Experimental; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Wistar	2006
Comparison of mode of action of four hepatocarcinogens: a model-based approach. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms; Male; Models, Biological; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Sex Characteristics; Substrate Specificity	2007
Scoring multiple toxicological endpoints using a toxicogenomic database. Toxicology letters, 2009, Jul-24, Volume: 188, Issue:2 Topics: 2-Acetylaminofluorene; Acetaminophen; Algorithms; Animals; Biomarkers; Clofibrate; Data Interpretation, Statistical; Databases, Genetic; Endpoint Determination; Gene Expression; Liver; Male; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Toxicity Tests; Toxicogenetics	2009
Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat. Toxicologic pathology, 2016, Volume: 44, Issue:8 Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Carcinogenicity Tests; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Female; Liver; Male; Neoplasms, Experimental; Organ Size; Organ Specificity; Phenobarbital; Precancerous Conditions; Rats, Wistar; Steroid Hydroxylases	2016