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2-acetylaminofluorene and n-(deoxyguanosin-8-yl)acetylaminofluorene

2-acetylaminofluorene has been researched along with n-(deoxyguanosin-8-yl)acetylaminofluorene in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199014 (31.11)18.7374
1990's17 (37.78)18.2507
2000's10 (22.22)29.6817
2010's4 (8.89)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Casciano, DA1
Beland, FA; Meerman, JH; Mulder, GJ; Timmers-Reker, AJ; Wedzinga, R; Wierckx, FC1
Brandtzaeg, P; Huitfeldt, HS; Poirier, MC1
Gentles, R; Grollman, AP; Johnson, F; Shibutani, S1
Gupta, PK; King, CM; Lee, MS; Pandrangi, RG1
Annan, RS; Giese, RW; Vouros, P1
Beland, FA; Fullerton, NF; Kinouchi, T; Poirier, MC; Smith, BA1
Retèl, J; van Grondelle, R; van Houte, LP; Westra, JG1
Gupta, PK; Johnson, DL; King, CM; Lee, MS; Reid, TM; Romano, LJ1
Meerman, JH; Mulder, GJ; Tates, AD; van de Poll, ML; van der Hulst, DA1
Geacintov, NE; Kim, SK; Retèl, J; Sutherland, JC; van Grondelle, R; van Houte, LP; Westra, JG; Zinger, D1
Abuaf, P; Broyde, S; Grunberger, D; Hingerty, BE; Live, D; Norman, D; Patel, DJ1
Arce, GT; Cline, DT; Mead, JE1
Den Engelse, L; Hermsen, T; Kriek, E; Menkveld, GJ; Scherer, E; Van der Laken, CJ1
Duker, NJ; Merkel, GW1
Duker, NJ; Hart, DM1
Bazgar, S; Leng, M; Rio, P1
Hagenaars, AM; Hermsen, G; Kriek, E; Kuipers, AJ; Nagel, J; Scherer, E; Van Der Laken, CJ; Welling, M1
Connor, RJ; Poirier, MC1
Evans, FE; Miller, DW1
Kriek, E; Westra, JG1
Doisy, R; Tang, MS1
Romano, LJ; Zhou, Y1
Beland, FA; Culp, SJ; Poirier, MC1
Coin, F; Fuchs, RP; Koffel-Schwartz, N; Veaute, X1
Downey, KM; Fisher, PA; Mozzherin, DJ; Shibutani, S; Tan, CK1
de Groot, AJ; Filon, R; Mullenders, LH; van Oosterwijk, MF; van Zeeland, AA1
Grollman, AP; Shibutani, S; Suzuki, N1
Cho, BP; Zhou, L1
Basu, AK; Broyde, S; Gorin, A; Gu, Z; Hingerty, BE; Krishnasamy, R; Patel, DJ1
Guo, D; Rajpal, DK; Taylor, JS; Wang, M; Wang, Z; Wu, X; Yuan, F; Zhang, Y1
Beland, FA; Evans, FE; Miller, DW1
Grollman, AP; Johnson, F; Shibutani, S; Suzuki, N; Tan, X1
Grollman, AP; Hayashi, K; Ohashi, E; Ohmori, H; Shibutani, S; Suzuki, N1
Hara, R; Sancar, A2
Grollman, AP; Shibutani, S; Suzuki, N; Tan, X1
Guo, D; Shen, H; Wang, Z; Xie, Z; Zhao, B1
Alzeer, J; Gillet, LC; Schärer, OD1
Broyde, S; Wang, L1
Broyde, S; Donny-Clark, K; Shapiro, R1
Carell, T; Schorr, S1
Broyde, S; Geacintov, NE; Kolbanovskiy, A; Kolbanovskiy, M; Kropachev, K; Mu, H; Wang, L; Zhang, L1
Markiewicz, RP; Romano, LJ; Rueda, D; Vrtis, KB1
Broyde, S; Ding, S; Geacintov, NE; Lior-Hoffmann, L; Zhang, Y1

Other Studies

45 other study(ies) available for 2-acetylaminofluorene and n-(deoxyguanosin-8-yl)acetylaminofluorene

ArticleYear
Metabolic activation in isolated rat hepatocytes.
    SAAS bulletin, biochemistry and biotechnology, 1990, Volume: 3

    Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Deoxyguanosine; DNA; DNA Damage; DNA Repair; Fluorenes; Liver; Male; Rats

1990
DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo.
    Carcinogenesis, 1991, Volume: 12, Issue:11

    Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Epoxide Hydrolases; Epoxy Compounds; Fluorenes; Injections, Intravenous; Liver; Male; Masoprocol; Rats; Rats, Inbred Strains; RNA; Trichloroepoxypropane; Trifluoroacetic Acid

1991
Carcinogen-induced alterations in rat liver DNA adduct formation determined by computerized fluorescent image analysis.
    Laboratory investigation; a journal of technical methods and pathology, 1991, Volume: 64, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cell Nucleus; Computers; Deoxyguanosine; DNA; Fluorescent Antibody Technique; Liver; Male; Microscopy, Fluorescence; Rats; Rats, Inbred F344

1991
Isolation and characterization of oligodeoxynucleotides containing dG-N2-AAF and oxidation products of dG-C8-AF.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: 2-Acetylaminofluorene; Chromatography, High Pressure Liquid; Deoxyguanosine; Electrophoresis, Polyacrylamide Gel; Fluorenes; Hydrogen-Ion Concentration; Mutagens; Oxidation-Reduction; Spectrophotometry, Ultraviolet

1991
Induction of mutations by N-acetoxy-N-acetyl-2-aminofluorene modified M13 viral DNA.
    Carcinogenesis, 1991, Volume: 12, Issue:5

    Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Base Sequence; Coliphages; Deoxyguanosine; DNA, Viral; Frameshift Mutation; Molecular Sequence Data; Mutation; Plasmids; SOS Response, Genetics; Transfection

1991
Detection and structural characterization of amino polyaromatic hydrocarbon-deoxynucleoside adducts using fast atom bombardment and tandem mass spectrometry.
    Analytical biochemistry, 1990, Nov-15, Volume: 191, Issue:1

    Topics: 2-Acetylaminofluorene; Deoxyguanosine; DNA; Fluorenes; Molecular Structure; Phenanthrenes; Spectrometry, Mass, Fast Atom Bombardment

1990
DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.
    Progress in clinical and biological research, 1990, Volume: 331

    Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Deoxyguanosine; DNA; DNA Damage; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Experimental; Mice; Urinary Bladder; Urinary Bladder Neoplasms

1990
The fluorescence emission properties of dGuo-C8-AAF, dGuo-C8-AF and the imidazole ring-opened products of dGuo-C8-AF indicate a different dynamic structure for the various compounds.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: 2-Acetylaminofluorene; Circular Dichroism; Deoxyguanosine; Fluorenes; Fluorescence; Imidazoles; Molecular Structure

1990
Mutagenesis by single site-specific arylamine-DNA adducts. Induction of mutations at multiple sites.
    The Journal of biological chemistry, 1989, Nov-25, Volume: 264, Issue:33

    Topics: 2-Acetylaminofluorene; Base Sequence; Coliphages; Deoxyguanosine; DNA, Viral; Escherichia coli; Fluorenes; Molecular Sequence Data; Mutagens; Mutation; Phenotype; Restriction Mapping; SOS Response, Genetics; Transfection

1989
The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo.
    Carcinogenesis, 1989, Volume: 10, Issue:4

    Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Mutagenicity Tests; Mutation; Pentachlorophenol; Rats; Rats, Inbred Strains; Time Factors

1989
Excited state properties of the N-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
    Photochemistry and photobiology, 1989, Volume: 49, Issue:4

    Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA; DNA Adducts; Fluorenes; Fluorescence; Spectrophotometry, Ultraviolet

1989
NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].A[anti] pair formation and its pH dependence.
    Biochemistry, 1989, Sep-05, Volume: 28, Issue:18

    Topics: 2-Acetylaminofluorene; Adenosine; Chemical Phenomena; Chemistry, Physical; Deoxyguanosine; DNA; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation

1989
The 32P-post-labeling method in quantitative DNA adduct dosimetry of 2-acetylaminofluorene-induced mutagenicity in Chinese hamster ovary cells and Salmonella typhimurium TA1538.
    Carcinogenesis, 1987, Volume: 8, Issue:4

    Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Cells, Cultured; Cricetinae; Deoxyguanosine; DNA; Dose-Response Relationship, Drug; Fluorenes; Mutagenicity Tests; Phosphorus Radioisotopes; Salmonella typhimurium

1987
Immunohistochemical localization of O6-ethyldeoxyguanosine and deoxyguanosin-8-yl-(acetyl)aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea or N-acetylaminofluorene.
    Carcinogenesis, 1985, Volume: 6, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Deoxyguanosine; Diethylnitrosamine; DNA; Ethylnitrosourea; Female; Histocytochemistry; Immunoenzyme Techniques; Liver; Nitrosamines; Nitrosourea Compounds; Rats; Rats, Inbred Strains

1985
Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid.
    Biochemistry, 1985, Jan-15, Volume: 24, Issue:2

    Topics: 2-Acetylaminofluorene; Deoxyguanosine; DNA; DNA Glycosylases; DNA Repair; N-Glycosyl Hydrolases; Pyrimidine Dimers; Ultraviolet Rays

1985
Perturbations of enzymic uracil excision due to guanine modifications in DNA.
    Cancer research, 1984, Volume: 44, Issue:2

    Topics: 2-Acetylaminofluorene; Bacillus subtilis; Bacteriophages; Deoxyguanosine; DNA Glycosylases; DNA, Viral; Kinetics; N-Glycosyl Hydrolases; Uracil; Uracil-DNA Glycosidase

1984
Detection of N-hydroxy-2-acetylaminofluorene-DNA adducts in rat liver measured by radioimmunoassay.
    Carcinogenesis, 1982, Volume: 3, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Antibody Formation; Antibody Specificity; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Injections, Intraperitoneal; Liver; Male; Methods; Radioimmunoassay; Rats; Rats, Inbred Lew

1982
Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays.
    Carcinogenesis, 1982, Volume: 3, Issue:5

    Topics: 2-Acetylaminofluorene; Animals; Deoxyguanosine; DNA; Enzyme-Linked Immunosorbent Assay; Radioimmunoassay; Reference Values

1982
Radioimmunoassay for 2-acetylaminofluorene-DNA adducts.
    Methods in enzymology, 1982, Volume: 84

    Topics: 2-Acetylaminofluorene; Animals; Cattle; Deoxyguanosine; DNA; Microchemistry; Rabbits; Radioimmunoassay

1982
Conformation and dynamics associated with the site of attachment of a carcinogen to a nucleotide.
    Biochemical and biophysical research communications, 1982, Oct-15, Volume: 108, Issue:3

    Topics: 2-Acetylaminofluorene; Binding Sites; Deoxyguanosine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation

1982
Structural identification of the pyrimidine derivatives formed from N-(deoxyguanosin-8-yl)-2-aminofluorene in aqueous solution at alkaline pH.
    Carcinogenesis, 1980, Volume: 1, Issue:6

    Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA; Fluorenes; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrimidines

1980
Effect of aminofluorene and (acetylamino)fluorene adducts on the DNA replication mediated by Escherichia coli polymerases I (Klenow fragment) and III.
    Biochemistry, 1995, Apr-04, Volume: 34, Issue:13

    Topics: 2-Acetylaminofluorene; Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Polymerase III; DNA Replication; DNA, Single-Stranded; Escherichia coli; Fluorenes; Molecular Sequence Data

1995
Solid-phase synthesis of oligonucleotides containing site-specific N-(2'-deoxyguanosin-8-yl)-2-(acetylamino)fluorene adducts using 9-fluorenylmethoxycarbonyl as the base-protecting group.
    Biochemistry, 1993, Dec-21, Volume: 32, Issue:50

    Topics: 2-Acetylaminofluorene; Base Sequence; Chromatography, High Pressure Liquid; Deoxyguanosine; Electrophoresis, Polyacrylamide Gel; Fluorenes; Guanine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligodeoxyribonucleotides

1993
Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.
    Environmental health perspectives, 1993, Volume: 99

    Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Deoxyguanosine; Diet; DNA; DNA Damage; DNA Repair; Fluorenes; Kinetics; Liver; Male; Rats; Rats, Inbred F344; Repetitive Sequences, Nucleic Acid

1993
Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Jul-23, Volume: 93, Issue:15

    Topics: 2-Acetylaminofluorene; Base Sequence; Carcinogens; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Replication; Escherichia coli; Fluorenes; Guanine; Molecular Sequence Data; Mutagenesis; Oligonucleotide Probes; Restriction Mapping; SOS Response, Genetics; Ultraviolet Rays

1996
Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Jun-10, Volume: 94, Issue:12

    Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Base Sequence; Binding Sites; Cattle; Deoxyguanosine; DNA Damage; DNA Polymerase III; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Fluorenes; Humans; Mammals; Mutagenesis; Proliferating Cell Nuclear Antigen; Recombinant Proteins; Templates, Genetic; Thymus Gland

1997
Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcription.
    The Journal of biological chemistry, 1998, May-29, Volume: 273, Issue:22

    Topics: 2-Acetylaminofluorene; Cells, Cultured; Deoxyguanosine; DNA Adducts; DNA Repair; DNA Replication; Fibroblasts; Humans; Transcription, Genetic

1998
Mutagenic specificity of (acetylamino)fluorene-derived DNA adducts in mammalian cells.
    Biochemistry, 1998, Sep-01, Volume: 37, Issue:35

    Topics: 2-Acetylaminofluorene; Animals; Catalysis; COS Cells; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Primers; Fluorenes; Genetic Vectors; Mutagenesis, Insertional; Mutagens; Sequence Deletion; Transfection

1998
Probing the conformational heterogeneity of the acetylaminofluorene-modified 2'-deoxyguanosine and DNA by 19F NMR spectroscopy.
    Biochemistry, 1999, Jun-08, Volume: 38, Issue:23

    Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA Adducts; DNA, Single-Stranded; Fluorenes; Fluorine; Models, Chemical; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Solvents; Thermodynamics

1999
Solution structure of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dA in a DNA duplex.
    Biochemistry, 1999, Aug-17, Volume: 38, Issue:33

    Topics: 2-Acetylaminofluorene; Carbon; Carcinogens, Environmental; Crystallography, X-Ray; Deoxyguanosine; DNA Adducts; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Phosphorus; Protons; Pyrenes; Solutions

1999
Specificity of DNA lesion bypass by the yeast DNA polymerase eta.
    The Journal of biological chemistry, 2000, Mar-17, Volume: 275, Issue:11

    Topics: 2-Acetylaminofluorene; Apurinic Acid; Deoxyguanosine; DNA Damage; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; DNA, Fungal; Guanine; Polynucleotides; Pyrimidine Dimers; Saccharomyces cerevisiae

2000
Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.
    Carcinogenesis, 1980, Volume: 1, Issue:11

    Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA; Fluorenes; Mutagens; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrenes

1980
Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA adducts in mammalian cells.
    Biochemistry, 2001, Mar-27, Volume: 40, Issue:12

    Topics: 2-Acetylaminofluorene; 3' Untranslated Regions; 5' Untranslated Regions; Animals; Base Sequence; Chlorocebus aethiops; COS Cells; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA Probes; Genetic Vectors; Mutagenesis, Site-Directed; Mutagens; Transfection

2001
Translesional synthesis past acetylaminofluorene-derived DNA adducts catalyzed by human DNA polymerase kappa and Escherichia coli DNA polymerase IV.
    Biochemistry, 2001, Dec-18, Volume: 40, Issue:50

    Topics: 2-Acetylaminofluorene; Animals; Base Sequence; COS Cells; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA-Directed DNA Polymerase; Escherichia coli; Fluorenes; Humans; In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Proteins; Recombinant Proteins; Sequence Deletion

2001
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.
    Molecular and cellular biology, 2002, Volume: 22, Issue:19

    Topics: 2-Acetylaminofluorene; Base Sequence; Chromatin; Deoxyguanosine; Deoxyribonucleases; DNA; DNA Footprinting; DNA Ligases; DNA Repair; DNA-Binding Proteins; Drosophila Proteins; Enzyme Activation; Humans; Macromolecular Substances; Models, Biological; Molecular Sequence Data; Nucleosomes; Replication Protein A; Ribonucleoprotein, U1 Small Nuclear; RNA-Binding Proteins; Substrate Specificity; Xeroderma Pigmentosum Group A Protein

2002
Mutagenic events in Escherichia coli and mammalian cells generated in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site.
    Biochemistry, 2002, Dec-03, Volume: 41, Issue:48

    Topics: 2-Acetylaminofluorene; Animals; Chlorocebus aethiops; COS Cells; Deoxyguanosine; Deoxyribonucleases, Type II Site-Specific; DNA Adducts; DNA Mutational Analysis; DNA, Single-Stranded; Escherichia coli; Fluorenes; Frameshift Mutation; Mutagens; Oligodeoxyribonucleotides; Plasmids; Point Mutation

2002
Effect of damage type on stimulation of human excision nuclease by SWI/SNF chromatin remodeling factor.
    Molecular and cellular biology, 2003, Volume: 23, Issue:12

    Topics: 2-Acetylaminofluorene; Base Sequence; Chromatin; Chromosomal Proteins, Non-Histone; Deoxyguanosine; Deoxyribonuclease I; Deoxyribonucleases; Dimerization; DNA Damage; DNA Repair; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Escherichia coli Proteins; HeLa Cells; Humans; Light; Molecular Sequence Data; Nucleosomes; Pyrimidine Dimers; Time Factors; Transcription Factors

2003
Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein.
    Nucleic acids research, 2004, Volume: 32, Issue:3

    Topics: 2-Acetylaminofluorene; Base Sequence; Deoxycytidine Monophosphate; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA-Directed DNA Polymerase; Mutagenesis; Nucleotidyltransferases; Saccharomyces cerevisiae Proteins; Templates, Genetic; Yeasts

2004
Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesis.
    Nucleic acids research, 2005, Volume: 33, Issue:6

    Topics: 2-Acetylaminofluorene; Biochemistry; Deoxyguanosine; DNA Adducts; DNA Repair; Fluorenes; HeLa Cells; Humans; Oligodeoxyribonucleotides

2005
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).
    Nucleic acids research, 2006, Volume: 34, Issue:3

    Topics: 2-Acetylaminofluorene; Base Pairing; Binding Sites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA Replication; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Sulfolobus solfataricus

2006
Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing?
    Biochemistry, 2009, Jan-13, Volume: 48, Issue:1

    Topics: 2-Acetylaminofluorene; Base Pairing; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA Polymerase iota; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Structure; Thermodynamics

2009
Mechanism of acetylaminofluorene-dG induced frameshifting by polymerase η.
    Chembiochem : a European journal of chemical biology, 2010, Dec-10, Volume: 11, Issue:18

    Topics: 2-Acetylaminofluorene; Base Sequence; Cloning, Molecular; Deoxyguanosine; DNA; DNA Damage; DNA-Directed DNA Polymerase; Escherichia coli; Frameshift Mutation; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2010
Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies.
    Nucleic acids research, 2012, Volume: 40, Issue:19

    Topics: 2-Acetylaminofluorene; Base Sequence; Deoxyguanosine; DNA Adducts; DNA Repair; Fluorenes; HeLa Cells; Humans; Molecular Dynamics Simulation; Nucleic Acid Conformation

2012
Carcinogenic adducts induce distinct DNA polymerase binding orientations.
    Nucleic acids research, 2013, Volume: 41, Issue:16

    Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; DNA Polymerase I; Fluorenes; Fluorometry; Protein Binding

2013
Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.
    Biochemistry, 2014, Sep-09, Volume: 53, Issue:35

    Topics: 2-Acetylaminofluorene; Base Pair Mismatch; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Substrate Specificity

2014