2-acetylaminofluorene has been researched along with hydroxyacetylaminofluorene in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 133 (93.01) | 18.7374 |
| 1990's | 6 (4.20) | 18.2507 |
| 2000's | 3 (2.10) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (0.70) | 2.80 |
| Authors | Studies |
|---|---|
| Jurs, PC; Yuta, K | 1 |
| Craven, PA; DeRubertis, FR | 1 |
| Grantham, PH; Poirier, LA; Rogers, AE | 1 |
| Daoud, AH; Griffin, AC | 1 |
| Becker, FF; Stout, DL | 1 |
| Schut, HA; Thorgeirsson, SS | 2 |
| Griffin, AC; Jacobs, MM; Matney, TS | 1 |
| Bhattacharya, PK; Kubinski, H; Kubinski, ZO; Morin, NR; Zeldin, PE | 1 |
| Castro, CE; Felkner, IC; Yang, SP | 1 |
| Custer, RP; Sorof, S; Tonelli, QJ | 1 |
| Dybing, E; Haug, LT; Søderlund, E; Thorgeirsson, SS | 1 |
| Allaben, WT; Lazear, EJ; Louie, SC | 1 |
| Becker, FF; Rodriguez, LV; Walker, MS | 1 |
| Arnott, MS; Griffin, AC; Jacobs, MM; Marshall, MV | 1 |
| Goodman, JI; Schwartz, EL | 1 |
| Austin, GE; Moyer, GH | 1 |
| Floyd, RA; Walker, RN | 1 |
| Casciano, DA; Cave, MD; Farr, JA; Oldham, JW | 1 |
| Miller, JA; Yager, JD | 1 |
| Baptist, JN; Matney, TS; Shaw, CR; Stout, DL | 1 |
| Grantham, PH; Idoine, JB; Mohan, LC; Weisburger, EK; Weisburger, JH | 1 |
| Gutmann, HR; Malejka-Giganti, D; Rydell, RE | 1 |
| Hopp, ML; Lee, C; Matsumoto, M; Oyasu, R | 1 |
| Bell, P; Gutmann, HR | 1 |
| Lhoest, G; Mercier, M; Razzouk, C; Roberfroid, M | 1 |
| McGregor, D | 1 |
| MacKinney, AA; Vyas, R | 1 |
| Hopp, ML; Lee, C; Matsumoto, M; Oyasu, R; Wendell, B | 1 |
| Monteith, DK | 1 |
| Meerman, JH; Tates, AD; van de Poll, ML; van der Hulst, DA | 1 |
| Erickson, J; Lohr, C; Mangold, BL; Mangold, JB; McCann, DJ | 1 |
| de Wit, H; Meerman, JH; Mulder, GJ; van den Goorbergh, JA | 1 |
| de Wit, H; Meerman, JH; Mulder, GJ; Tijdens, RB; van den Goorbergh, JA | 1 |
| Decker, RW; Magat, WJ; Malejka-Giganti, D | 1 |
| Meerman, JH; Tijdens, RB | 1 |
| Gutmann, HR; Smith, BA; Springfield, JR | 3 |
| Harris, C; Juchau, MR; Luchtel, DL; Stark, KL | 1 |
| Harris, C; Juchau, MR; Stark, KL | 2 |
| Lee, MS; Nagase, H; Wang, CY; Zukowski, K | 1 |
| Meerman, JH; Mulder, GJ; Tates, AD; van de Poll, ML; van der Hulst, DA | 1 |
| Glowinski, IB; King, CM; Vaught, JB | 1 |
| Meerman, JH | 1 |
| Kroese, ED; Meerman, JH; Mulder, GJ; Tijdens, RB | 1 |
| Krca, S; Kurelec, B | 1 |
| Kroese, ED; Meerman, JH; Mulder, GJ; van de Poll, ML | 1 |
| Hanna, PE; Smith, TJ | 2 |
| Meerman, JH; Mulder, GJ; Tijdens, RB | 1 |
| Beland, FA; Casciano, DA; Djurić, Z; Fullerton, NF; Heflich, RH; Zhuo, Z | 1 |
| Hanna, PE; Jantan, IB; Wick, MJ | 1 |
| Lai, CC; Liem, A; Miller, EC; Miller, JA | 3 |
| Fukui, S; Hirai, K; Hirayama, T; Ogawa, S; Tokuda, M | 1 |
| Birkett, DJ; Burgess, W; McManus, ME; Morley, AA; Stupans, I; Trainor, KJ | 1 |
| Blanck, A; Eriksson, LC; Wicksell, L | 1 |
| Imaida, K; Lee, MS; Wang, CY; Zukowski, K | 1 |
| Meerman, JH; Mulder, GJ; Nijland, C | 1 |
| Corbett, BR; Corbett, MD; Lim, LO | 1 |
| Hultin, TA; Weber, WW | 1 |
| Blanck, A; Eriksson, LC; Gustafsson, JA; Hansson, T | 1 |
| Eustice, DC; Mignano, JE; Poirier, MC; Yager, JD; Zurlo, J | 1 |
| Kitamura, S; Tatsumi, K | 1 |
| Decker, RW; Malejka-Giganti, D; Ritter, CL; Suilman, JM | 1 |
| McQueen, CA; Way, BM; Williams, GM | 1 |
| Glatt, H; Oesch, F | 1 |
| Boberg, EW; Delclos, KB; Fennell, TR; Lai, CC; Liem, A; Miller, EC; Miller, JA; Wiseman, RW | 1 |
| Grantham, PH; Hankins, WD; Roller, PP; Thorgeirsson, SS; Vu, VT; Wirth, PJ | 1 |
| McQueen, CA; Miller, MJ | 1 |
| Ebner, NA; Hanna, PE; Marhevka, VC; Sehon, RD | 1 |
| Holme, JA; Søderlund, EJ | 2 |
| Hayashi, S; McManus, ME; Razzouk, C; Schwartz, D; Thorgeirsson, SS | 1 |
| Daune, MP; Fuchs, RP; Koffel-Schwartz, N; Westhof, E | 1 |
| Malejka-Giganti, D; Ritter, CL | 1 |
| Grantham, PH; Møller, ME; Thorgeirsson, SS; Vu, VT; Wirth, PJ | 1 |
| Kuroiwa, Y; Matsuura, Y; Yamamoto, T; Yoshida, T | 1 |
| Bakker, O; Bisschop, A; Meerman, JH; Stavenuiter, JF; van der Heijden, CA; van Wijk, R | 1 |
| Groothuis, GM; Hardonk, MJ; Hulstaert, CE; Kalicharan, D | 1 |
| Sakai, S; Thorgeirsson, SS; Wirth, PJ | 1 |
| Meerman, JH; Mulder, GJ; van Doorn, AB | 1 |
| Beland, FA; Casciano, DA; Howard, PC; Shaddock, JG | 1 |
| Andrews, LS; Gillette, JR; Hinson, JA | 1 |
| Rauckman, EJ; Rosen, GM | 1 |
| Floyd, RA; Steward, JE | 1 |
| Floyd, RA | 1 |
| Hicks, RM; Knowles, MA; Moore, BP; Redgrave, S | 1 |
| Li, JJ; Li, SA; Malejka-Giganti, D | 1 |
| Dybing, E; Haug, LT; Holme, JA | 1 |
| Dybing, E; Haug, LT; Hongslo, J; Møller, M; Thorgeirsson, SS; Wirth, PJ | 1 |
| El-Torkey, NM; Weisburger, EK | 1 |
| Beranek, DT; Heflich, RH; White, GL | 1 |
| Ahluwalia, MB; Chan, C; Farber, E; Lee, G; Roberts, E; Sarma, DS | 1 |
| Krugh, TR; Winkle, SA | 1 |
| Fantel, AG; Faustman-Watts, EM; Greenaway, JC; Juchau, MR; Namkung, MJ | 1 |
| Marshall, MV; Purdy, RH | 1 |
| Gupta, RC | 1 |
| Groothuis, GM; Hardonk, MJ; Meijer, DK; Weitering, JG | 1 |
| Glowinski, IB; Hayashi, S; Sanderson, ND; Thorgeirsson, SS | 1 |
| Dighe, NR; Gupta, RC | 1 |
| Glowinski, IB; Møller, ME; Thorgeirsson, SS | 1 |
| Beland, FA; Beranek, DT; Heflich, RH; White, GL | 1 |
| Jacobs, MM | 1 |
| Malejka-Giganti, D | 1 |
| Gonzalez, FJ; Kasper, CB; McQuiddy, P; Samore, M | 1 |
| Groothuis, GM; Hardonk, MJ; Meijer, DK | 1 |
| Groothuis, GM; Hardonk, MJ; Keulemans, KP; Meijer, DK; Mulder, D; Weitering, JG | 1 |
| Allaben, WT; Beland, FA; Fullerton, NF; Weis, CC | 1 |
| Alewood, P; Calder, I; Thorgeirsson, SS; Wirth, PJ | 1 |
| Reddy, TV; Thorgeirsson, SS; Weisburger, EK | 1 |
| Braselton, WE; Goodman, JI; Schwartz, EL | 1 |
| Thorgeirsson, SS; Wirth, PJ | 1 |
| Kaneda, S; Seno, T; Takeishi, K | 1 |
| Beland, FA; Dooley, KL; Jackson, CD | 1 |
| King, CM; Shirai, T | 1 |
| Bazgar, S; Leng, M; Rio, P | 1 |
| Allaben, WT; King, CM; Lazear, EJ; Louie, SC; Tresp, NM; Weeks, CE | 1 |
| Erickson, LC; Staiano, N; Thorgeirsson, SS | 1 |
| Beland, FA; Bruins, AP; Ketterer, B; Meerman, JH; Mulder, GJ; Srai, SK | 1 |
| Flaks, A; Flaks, B; Yost, Y | 1 |
| Allaben, WT; Burger, GT; King, CM; Weeks, CE; Weis, CC | 1 |
| Batardy-Grégoire, M; Razzouk, C; Roberfroid, M | 2 |
| Meerman, JH; Mulder, GJ | 1 |
| Chow, YM; Gutmann, HR; Kaplan, E | 1 |
| Beland, FA; Meerman, JH; Mulder, GJ | 1 |
| Gillette, JR; Hinson, JA; Pohl, LR | 1 |
| Cole, CA; Fletcher, TL; Pan, HL | 1 |
| Austin, GE; Lepay, D; Moyer, GH | 1 |
| Ishii, K; Kamataki, T; Kato, R; Yamaguchi, N; Yamazoe, Y | 1 |
| Allaben, WT; Beland, FA; Evans, FE | 1 |
| Duffel, MW; Howell, BA; Kosanke, SD; Norton, TR; Ringer, DP; Woulfe, GW | 1 |
| Ambs, S; Neumann, HG | 1 |
| Kitamura, S; Ohta, S; Sugihara, K; Takekawa, K; Tatsumi, K | 1 |
| Famourzadeh, M; Guengerich, FP; Nguyen, N; Oda, Y; Strassburg, CP; Tukey, RH; Yueh, MF | 1 |
| Fuchs, RP; Hoffmann, GR; Janel-Bintz, R | 1 |
| Cheo, DL; Friedberg, EC | 1 |
| HARTMANN, HA | 1 |
| Arlt, VM; Barnett, BC; Downs, TR; Pfuhler, S; Posgai, R | 1 |
2 review(s) available for 2-acetylaminofluorene and hydroxyacetylaminofluorene
| Article | Year |
|---|---|
Macromolecular complexes produced by chemical carcinogens and ultraviolet radiation.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Albumins; Alkylating Agents; Carcinogens; Centrifugation, Isopycnic; Chemical Phenomena; Chemistry; Chromatography, Gel; DNA; Ethyl Methanesulfonate; Hydroxyacetylaminofluorene; In Vitro Techniques; Mechlorethamine; Methyl Methanesulfonate; Muramidase; Proteins; RNA; Ultraviolet Rays | 1977 |
Sulfuric acid esters as ultimate electrophilic and carcinogenic metabolites of some alkenylbenzenes and aromatic amines in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Azo Compounds; Biotransformation; Carcinogens; Chemical Phenomena; Chemistry; Dioxoles; DNA, Neoplasm; Hydroxyacetylaminofluorene; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Mice; p-Aminoazobenzene; Phosphoadenosine Phosphosulfate; Safrole; Sulfates; Sulfurtransferases | 1985 |
141 other study(ies) available for 2-acetylaminofluorene and hydroxyacetylaminofluorene
| Article | Year |
|---|---|
Computer-assisted structure-activity studies of chemical carcinogens. Aromatic amines.
Topics: Amines; Animals; Binding Sites; Carcinogens; Computers; Pattern Recognition, Automated; Rats; Structure-Activity Relationship | 1981 |
Activatin of guanylate cyclase during the oxidation of arylamine carcinogens.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; Cytosol; Enzyme Activation; Guanylate Cyclase; Hydroxyacetylaminofluorene; Linoleic Acids; Liver; Male; Peroxides; Rats | 1979 |
The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Choline Deficiency; Diet; Female; Fluorenes; Folic Acid Deficiency; Glutathione; Hydroxyacetylaminofluorene; Lipotropic Agents; Liver; Male; Methionine; Microsomes, Liver; Nitroanisole O-Demethylase; Rats; S-Adenosylmethionine; Sex Factors | 1977 |
Effects of selenium and retinoic acid on the metabolism of N-acetylaminofluorene and N-hydroxyacetylamino-fluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; DNA; Fluorenes; Glucuronosyltransferase; Hydroxyacetylaminofluorene; Liver; Male; Nitrophenols; Rats; RNA, Transfer; Selenium; Sulfotransferases; Sulfurtransferases; Tretinoin; Vitamin A | 1978 |
Alteration of the ability of liver microsomes to activate N-2-fluorenylacetamide to a mutagen of Salmonella typhimurium during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Fluorenes; Hydroxyacetylaminofluorene; Liver Neoplasms; Male; Microsomes, Liver; Mutagens; Precancerous Conditions; Rats; Salmonella typhimurium; Time Factors | 1978 |
Mutagenic activation of N-hydroxy-2-acetylaminofluorene by developing epithelial cells of rat small intestine and effects of antioxidants.
Topics: 2-Acetylaminofluorene; Animals; Antioxidants; Ascorbic Acid; Biotransformation; Cytosol; Drug Evaluation, Preclinical; Epithelium; Hydroxyacetylaminofluorene; In Vitro Techniques; Intestine, Small; Mutagens; Paraoxon; Rats; Selenium | 1979 |
Inhibitory effects of selenium of the mutagenicity of 2-acetylaminofluorene (AAF) and AAF derivatives.
Topics: 2-Acetylaminofluorene; Animals; Dose-Response Relationship, Drug; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Microsomes, Liver; Mutation; Rats; Salmonella typhimurium; Selenium | 1977 |
In vitro metabolism and mutagenic activation of 2-acetylaminofluorene by subcellular liver fractions from Cotton rats.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Flavonoids; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Naphthalenes; Paraoxon; Rats; Salmonella typhimurium; Species Specificity | 1978 |
Dietary lipid-dependent activation of the carcinogen N-2-fluorenylacetamide in rats as monitored by Salmonella typhimurium.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Dietary Fats; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Male; Microsomes, Liver; Mutation; Rats; Salmonella typhimurium | 1978 |
Transformation of cultured mouse mammary glands by aromatic amines and amides and their derivatives.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; 2-Naphthylamine; Acetoxyacetylaminofluorene; Animals; Cell Transformation, Neoplastic; Female; Fluorenes; Hydroxyacetylaminofluorene; Mammary Neoplasms, Experimental; Mice; Naphthalenes; Organ Culture Techniques | 1979 |
Metabolism and activation of 2-acetylaminofluorene in isolated rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Biotransformation; Female; Flavonoids; Fluorenes; Hydroxyacetylaminofluorene; Hydroxylation; Liver; Male; Mutagens; Naphthalenes; Nitrophenols; Phenylenediamines; Protein Binding; Rats | 1979 |
Synergistic effect of diethylstilbestrol on the mutagenicity of 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene in the Salmonella assay system.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Diethylstilbestrol; Drug Evaluation, Preclinical; Drug Synergism; Female; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mice; Mutagens; Rats | 1979 |
In vivo binding of N-2-acetylaminofluorene and its N-hydroxy derivative to the DNA of fractionated rat liver chromatin.
Topics: 2-Acetylaminofluorene; Animals; Centrifugation, Density Gradient; Chromatin; Deoxyribonucleases; Diet; DNA; Endonucleases; Hydroxyacetylaminofluorene; Liver; Male; Micrococcal Nuclease; Rats; Time Factors | 1979 |
Selenium effects on the carcinogenicity and metabolism of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Microsomes, Liver; Rats; Selenium | 1979 |
Quantitative and qualitative aspects of the binding of N-hydroxy-2-acetylaminofluorene to hepatic chromatin fractions.
Topics: 2-Acetylaminofluorene; Animals; Chemical Phenomena; Chemistry; Chromatin; Chromatography, Thin Layer; DNA; Hydroxyacetylaminofluorene; Liver; Male; Proteins; Rats; Time Factors | 1979 |
The acute effects of N-hydroxy-acetylaminofluorene on rat liver protein synthesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Cell-Free System; Centrifugation, Density Gradient; Cytoplasm; Hydroxyacetylaminofluorene; Liver; Male; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Polyribosomes; Protein Biosynthesis; Rats; RNA; Seeds; Triticum | 1979 |
Free radical activation of N-hydroxy-2-acetylaminofluorene by methemoglobin and hydrogen peroxide.
Topics: 2-Acetylaminofluorene; Animals; Cattle; Free Radicals; Hydrogen Peroxide; Hydroxyacetylaminofluorene; Kinetics; Methemoglobin; Spectrophotometry, Ultraviolet | 1979 |
2-acetylaminofluorene-induced unscheduled DNA synthesis in hepatocytes isolated from 3-methylcholanthrene treated rats.
Topics: 2-Acetylaminofluorene; Animals; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Synergism; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Methylcholanthrene; Rats | 1978 |
DNA repair in primary cultures of rat hepatocytes.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Cells, Cultured; DNA; DNA Repair; Fluorenes; Hydroxyacetylaminofluorene; Liver; Male; Rats; Thymidine; Ultraviolet Rays | 1978 |
N'-hydroxy-2-aminofluorene: the principal mutagen produced from N-hydroxy-2-acetylaminofluorene by a mammalian supernatant enzyme preparation.
Topics: 2-Acetylaminofluorene; Animals; Fluorenes; Hydroxyacetylaminofluorene; Hydroxylamines; In Vitro Techniques; Microsomes, Liver; Mutagens; Rats; Salmonella typhimurium | 1976 |
Mechanisms of the inhibitory action of p-hydroxyacetanilide on carcinogenesis by N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Acetaminophen; Amidohydrolases; Animals; Body Weight; Eating; Feces; Fluorenes; Glucuronates; Glucuronosyltransferase; Hydroxyacetylaminofluorene; Liver; Male; Protein Binding; Rats; Rats, Inbred F344; Sulfuric Acids | 1976 |
Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acids and their acetates.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetylation; Administration, Topical; Animals; Cytochrome P-450 Enzyme System; Estradiol; Female; Fluorenes; Hydroxyacetylaminofluorene; Hydroxylation; Mammary Neoplasms, Experimental; Microsomes; Microsomes, Liver; Ovary; Rats | 1977 |
Absorption and protein binding of N-2-fluorenylacetamide and its metabolites in the bladder of rabbit.
Topics: 2-Acetylaminofluorene; Absorption; Acetylation; Animals; Fluorenes; Glucuronates; Glucuronidase; Hydroxyacetylaminofluorene; In Vitro Techniques; Male; Protein Binding; Rabbits; RNA; Urinary Bladder | 1977 |
N-Hydroxylation of arylamides by the rat and guinea pig. Evidence for substrate specificity and participation of cytochrome P1-450.
Topics: 2-Acetylaminofluorene; Animals; Bile; Cobalt; Cytochrome P-450 Enzyme System; Female; Fluorenes; Fluorides; Guinea Pigs; Hydroxyacetylaminofluorene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet | 1977 |
Subnanogram estimation of the proximate carcinogen N-hydryxy-2-fluorenylacetamide by gas-liquid chromatography.
Topics: 2-Acetylaminofluorene; Cell-Free System; Chromatography, Gas; Fluorenes; Hydroxyacetylaminofluorene; Hydroxylation; Mass Spectrometry; Microsomes, Liver | 1977 |
The relationship of 2-acetamidofluorene mutagenicity in plate tests with its in vivo liver cell component distribution and its carcinogenic potential.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Fractionation; Cricetinae; Diet; DNA; Female; Fluorenes; Guinea Pigs; Hydroxyacetylaminofluorene; Liver; Male; Methylcholanthrene; Mutagens; Mutation; Papio; Rats; RNA, Ribosomal; Salmonella typhimurium | 1975 |
Effects of 5,5-diphenylhydantoin and related carbamates and hydroxylamines on nucleic acid and protein synthesis of proliferating human lymphocytes.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Blood Proteins; Carbamates; DNA; Humans; Hydantoins; Hydroxyacetylaminofluorene; Hydroxylamines; In Vitro Techniques; Leucine; Lymphocytes; Phenytoin; Structure-Activity Relationship; Thymidine | 1975 |
Suppressive role of indole on 2-acetylaminofluorene hepatotoxicity.
Topics: 2-Acetylaminofluorene; Animals; Bile; Fluorenes; Hydroxyacetylaminofluorene; Indoles; Liver; Male; Rats; Sulfates | 1976 |
Inhibition of sulfotransferase in primary cultures of human hepatocytes affecting metabolism and binding of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Adult; Biotransformation; DNA; Female; Humans; Hydroxyacetylaminofluorene; Liver; Male; Pentachlorophenol; Sulfotransferases | 1992 |
Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4'-fluoro-4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Micronuclei, Chromosome-Defective; Mutagens; Rats; Rats, Inbred Strains | 1990 |
Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Chromatography, Gel; Hydroxyacetylaminofluorene; Kinetics; Liver; Methionine; Rats | 1990 |
Reaction of 2-acetylaminofluorene-N-sulfate with RNA and glutathione: evidence for the generation of two reactive intermediates with different reactivities towards RNA and glutathione.
Topics: 2-Acetylaminofluorene; Cysteine; Glutathione; Hydroxyacetylaminofluorene; Potassium Chloride; RNA | 1985 |
Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Benzoates; DNA Damage; Hydroxyacetylaminofluorene; Liver; Male; Proteins; Rats; RNA; Sulfides | 1987 |
Sex hormone-mediated effects on the phase I and phase II metabolism of N-2-fluorenylacetamide. Modulation of 9-hydroxylation.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Female; Glucuronosyltransferase; Gonadal Steroid Hormones; Hydroxyacetylaminofluorene; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; Orchiectomy; Ovariectomy; Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Effect of glutathione depletion on the hepatotoxicity and covalent binding rat liver macromolecules of N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Cysteine; DNA; Glutathione; Hydroxyacetylaminofluorene; In Vitro Techniques; Kidney; Liver; Male; Maleates; Nitrophenols; Protein Binding; Rats; Rats, Inbred Strains; RNA; Sulfuric Acids | 1985 |
Catalytic effect of serum albumin on the o-rearrangement of N-sulfooxy-2-acetylaminofluorene, a potential hepatocarcinogen in the rat, to nonmutagenic sulfuric acid esters of o-amidofluorenols.
Topics: 2-Acetylaminofluorene; Animals; Catalysis; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Hot Temperature; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Molecular Structure; Protein Denaturation; Rats; Serum Albumin, Bovine; Structure-Activity Relationship; Sulfuric Acids | 1989 |
Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Animals; Biological Availability; Catechols; DNA; Embryo, Mammalian; Enzyme Induction; Hydroxyacetylaminofluorene; Inactivation, Metabolic; Liver; Methylcholanthrene; Neural Tube Defects; Organ Culture Techniques; Proteins; Rats | 1989 |
Modulation of the embryotoxicity and cytotoxicity elicited by 7-hydroxy-2-acetylaminofluorene and acetaminophen via deacetylation.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Acetylation; Animals; Cell Survival; Embryo, Mammalian; Embryonal Carcinoma Stem Cells; Female; Hydroxyacetylaminofluorene; Neoplastic Stem Cells; Neural Tube Defects; Pregnancy; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
Inhibition by diacylmethane derivatives of mutagenicity and nucleic acid binding of 2-aminofluorene derivatives.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Benzoates; Butanones; Chalcones; Drug Evaluation, Preclinical; Drug Interactions; Fluorenes; Hydroxyacetylaminofluorene; Indans; Indenes; Ketones; Male; Mutagens; Mutation; Nucleic Acids; Pentanones; Rats; RNA, Transfer; Salmonella typhimurium | 1989 |
The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Mutagenicity Tests; Mutation; Pentachlorophenol; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Metabolism of N-hydroxy-2-acetylaminofluorene and N-hydroxy-phenacetin by guinea pig liver microsomal enzymes.
Topics: 2-Acetylaminofluorene; Acetyl-CoA Hydrolase; Animals; Binding, Competitive; Chromatography, Gel; Chromatography, High Pressure Liquid; Colorimetry; Female; Guinea Pigs; Hydroxyacetylaminofluorene; In Vitro Techniques; Microsomes, Liver; Phenacetin; RNA, Transfer; Thiolester Hydrolases | 1985 |
The initiation of gamma-glutamyltranspeptidase positive foci in the rat liver by N-hydroxy-2-acetylaminofluorene. The effect of the sulfation inhibitor pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chlorophenols; Enzyme Induction; gamma-Glutamyltransferase; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms; Male; Pentachlorophenol; Rats; Rats, Inbred Strains | 1985 |
Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Chlorophenols; gamma-Glutamyltransferase; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Pentachlorophenol; Precancerous Conditions; Rats; Rats, Inbred Strains; Sulfurtransferases | 1987 |
Metabolic activation of 2-aminofluorene, 2-acetylaminofluorene and N-hydroxy-acetylaminofluorene to bacterial mutagens with mussel (Mytilus galloprovincialis) and carp (Cyprinus carpio) subcellular preparations.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Bivalvia; Carps; Cyprinidae; Digestive System; Fluorenes; Hydroxyacetylaminofluorene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Salmonella typhimurium; Subcellular Fractions | 1987 |
The role of N-sulfation in the N-hydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to gamma-glutamyltranspeptidase-positive foci in male rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Pentachlorophenol; Precancerous Conditions; Rats; Rats, Inbred Strains; Sulfates; Sulfotransferases | 1988 |
Glutathione status and the incidence of neural tube defects elicited by direct acting teratogens in vitro.
Topics: 2-Acetylaminofluorene; Animals; Cytochalasin D; Cytochalasins; Female; Glutathione; Hydroxyacetylaminofluorene; Neural Tube Defects; Organ Culture Techniques; Pregnancy; Rats; Rats, Inbred Strains; Reference Values; Teratogens; Valproic Acid | 1988 |
Hepatic N-acetyltransferases: selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid.
Topics: 2-Acetylaminofluorene; 4-Aminobenzoic Acid; Acetyl Coenzyme A; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Cricetinae; Hydroxyacetylaminofluorene; Kinetics; Liver; Male; Mesocricetus | 1988 |
The binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: effects of glutathione and methionine.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; DNA; DNA Damage; Glutathione; Hydroxyacetylaminofluorene; Liver; Male; Methionine; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1986 |
Metabolism of 2-acetylaminofluorene in the Chinese hamster ovary cell mutation assay.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetyl Coenzyme A; Acetylation; Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Cytosol; DNA Damage; Female; Fibroblasts; Fluorenes; Hydroxyacetylaminofluorene; Mutagenicity Tests; Ovary; Oxidation-Reduction; Paraoxon | 1988 |
Irreversible inhibition of rat hepatic transacetylase activity by N-arylhydroxamic acids.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Animals; Carbazoles; Cysteine; Hydroxamic Acids; Hydroxyacetylaminofluorene; Kinetics; Liver; Male; Methionine; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
The essential role of microsomal deacetylase activity in the metabolic activation, DNA-(deoxyguanosin-8-yl)-2-aminofluorene adduct formation and initiation of liver tumors by N-hydroxy-2-acetylaminofluorene in the livers of infant male B6C3F1 mice.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Animals, Newborn; Biotransformation; Cytosol; DNA Damage; Hydroxyacetylaminofluorene; Liver Neoplasms; Male; Mice; Microsomes, Liver; Nitrophenols; Rats | 1988 |
N-acetyltransferase multiplicity and the bioactivation of N-arylhydroxamic acids by hamster hepatic and intestinal enzymes.
Topics: 2-Acetylaminofluorene; 4-Aminobenzoic Acid; Acetylation; Acetyltransferases; Acyltransferases; Aminobenzoates; Animals; Biotransformation; Carcinogens; Chromatography, Affinity; Cricetinae; Hydroxyacetylaminofluorene; Intestines; Liver; Male; Mesocricetus; p-Aminoazobenzene; Phenacetin; RNA, Transfer | 1986 |
Interaction of the synthetic ultimate carcinogens, N-sulfonoxy- and N-acetoxy-2-acetylaminofluorene, and of enzymatically activated N-hydroxy-2-acetylaminofluorene with nucleophiles.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Chemical Phenomena; Chemistry; Guanosine; Hydroxyacetylaminofluorene; Male; Methionine; Mutagenicity Tests; Mutation; Poly G; Rats; RNA, Transfer; Salmonella typhimurium | 1986 |
Mutagenicity-enhancing effect of quercetin on the active metabolites of 2-acetylaminofluorene with mammalian metabolic activation systems.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetylation; Animals; Biotransformation; Cytosol; Drug Synergism; Flavonoids; Fluorenes; Hydroxyacetylaminofluorene; Hydroxylation; Inactivation, Metabolic; Male; Microsomes, Liver; Mutagenicity Tests; Quercetin; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1987 |
Metabolism of 2-acetylaminofluorene in cultured human lymphocytes.
Topics: 2-Acetylaminofluorene; Biotransformation; Cells, Cultured; Cytochrome P-450 Enzyme System; Humans; Hydroxyacetylaminofluorene; Lymphocytes; Metyrapone | 1987 |
Sulfation of N-hydroxy-2-acetylaminofluorene in normal and nodular liver from male Wistar rats.
Topics: 2-Acetylaminofluorene; Androstenedione; Animals; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Oxazines; Precancerous Conditions; Rats; Rats, Inbred Strains; Sulfates | 1987 |
Production of urothelial tumors in the heterotopic bladder of rats by instillation of N-glucuronosyl or N-acetyl derivatives of N-hydroxy-2-aminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Epithelium; Fluorenes; Glucuronates; Hydroxyacetylaminofluorene; Male; Metabolic Clearance Rate; Methylnitrosourea; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1987 |
Sex differences in sulfation and glucuronidation of phenol, 4-nitrophenol and N-hydroxy-2-acetylaminofluorene in the rat in vivo.
Topics: 2-Acetylaminofluorene; Animals; Bile; Female; Glucuronates; Hydroxyacetylaminofluorene; Male; Nitrophenols; Phenol; Phenols; Rats; Rats, Inbred Strains; Sex Characteristics; Sulfates | 1987 |
Irreversible inhibition of the cytosolic metabolism of N-hydroxy-2-acetylaminofluorene by its glycolyl analog.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Hydroxyacetylaminofluorene; Male; Rats; Rats, Inbred Strains | 1987 |
Genetic variability in deacetylation of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in inbred strains of mice.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Animals; Hydroxyacetylaminofluorene; Mice; Mice, Inbred Strains; Species Specificity | 1987 |
Pituitary grafts modify sex differences in liver tumor formation in the rat following initiation with diethylnitrosamine and different promotion regimens.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Disease Models, Animal; Female; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Sex Factors | 1986 |
Effects of carcinogen treatment on rat liver DNA synthesis in vivo and on nascent DNA synthesis and elongation in cultured hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Caffeine; Cells, Cultured; DNA Repair; DNA Replication; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Rats; Rats, Inbred Strains; Ultraviolet Rays | 1986 |
N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidase; Aldehyde Oxidoreductases; Aminobiphenyl Compounds; Animals; Cysteine; Dithiothreitol; Fluorenes; Glutathione; Hydroxamic Acids; Hydroxyacetylaminofluorene; Kinetics; Male; Phenacetin; Rabbits; Serum Albumin, Bovine | 1986 |
Peroxidative metabolism of a carcinogen, N-hydroxy-N-2-fluorenylacetamide, by rat uterus and mammary gland in vitro.
Topics: 2-Acetylaminofluorene; Animals; DNA; Female; Hydroxyacetylaminofluorene; In Vitro Techniques; Lactoperoxidase; Mammary Glands, Animal; Nitroso Compounds; Oxidation-Reduction; Peroxidases; Rats; Rats, Inbred Strains; Uterus | 1986 |
Biotransformation of aromatic amines to DNA-damaging products by urinary bladder organ cultures.
Topics: 2-Acetylaminofluorene; Animals; Benzidines; Biotransformation; Carcinogens; DNA Damage; DNA Repair; DNA Replication; Fluorenes; Hydroxyacetylaminofluorene; Organ Culture Techniques; Rabbits; Urinary Bladder | 1987 |
Initiation of hepatocarcinogenesis in infant male B6C3F1 mice by N-hydroxy-2-aminofluorene or N-hydroxy-2-acetylaminofluorene depends primarily on metabolism to N-sulfooxy-2-aminofluorene and formation of DNA-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; Female; Fluorenes; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Pentachlorophenol; Phosphorus Radioisotopes; Tritium | 1987 |
N-sulfoöxy-2-aminofluorene is the major ultimate electrophilic and carcinogenic metabolite of N-hydroxy-2-acetylaminofluorene in the livers of infant male C57BL/6J x C3H/HeJ F1 (B6C3F1) mice.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Carcinogens; Crosses, Genetic; Cytosol; DNA; Female; Hydroxyacetylaminofluorene; Liver; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Phenotype; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfurtransferases; Tritium | 1985 |
Activation of N-acetoxy- and N-hydroxy-2-acetylaminofluorene to mutagenic and cytotoxic metabolites by V79 Chinese hamster cells.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Cell Line; Cricetinae; Cricetulus; Hydroxyacetylaminofluorene; Mutagenicity Tests; Mutagens; Paraoxon; Salmonella typhimurium | 1985 |
Formation of DNA adducts from N-acetoxy-2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in rat hemopoietic tissues in vivo.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Bone Marrow; DNA; Fluorouracil; Hematopoietic Stem Cells; Hydroxyacetylaminofluorene; Kidney; Liver; Male; Rats; Rats, Inbred F344; Spleen | 1986 |
High-performance liquid chromatographic analysis of 2-aminofluorene and its metabolites in monolayer cultures of rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Fluorenes; Hydroxyacetylaminofluorene; Liver; Rats | 1986 |
Mechanism-based inactivation of N-arylhydroxamic acid N,O-acyltransferase by 7-substituted-N-hydroxy-2-acetamidofluorenes.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Acyltransferases; Animals; Cricetinae; Cysteine; Glutathione; Hydroxyacetylaminofluorene; Liver; Male; Mathematics; Mesocricetus; Molecular Weight; Structure-Activity Relationship | 1985 |
Interaction of nucleophiles with the enzymatically-activated carcinogen, N-hydroxy-2-acetylaminofluorene, and with the model ester, N-acetoxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Chromatography, High Pressure Liquid; Hydroxyacetylaminofluorene; Male; Methionine; Oxidation-Reduction; Poly G; Rats; Rats, Inbred Strains; RNA, Transfer | 1985 |
Species differences in the cytotoxic and genotoxic effects of 2-acetylaminofluorene and its primary metabolites 2-aminofluorene and N-OH-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cricetinae; DNA Repair; Fluorenes; Guinea Pigs; Hydroxyacetylaminofluorene; Liver; Male; Mesocricetus; Mice; Mutagens; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Enzyme Induction; Epoxide Hydrolases; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes | 1985 |
Covalent binding of a carcinogen as a probe for the dynamics of deoxyribonucleic acid.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Cattle; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Kinetics; Mathematics; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Spectrophotometry; Stereoisomerism; Temperature | 1985 |
A novel oxidation of the carcinogen N-hydroxy-N-2-fluorenylacetamide catalyzed by peroxidase/H2O2/Br-.
Topics: 2-Acetylaminofluorene; Animals; Bromides; Female; Hydrogen Peroxide; Hydroxyacetylaminofluorene; Kinetics; Lactoperoxidase; Nitroso Compounds; Oxidation-Reduction; Peroxidases; Rats; Rats, Inbred Strains; Uterus | 1985 |
Association between DNA strand breaks and specific DNA adducts in murine hepatocytes following in vivo and in vitro exposure to N-hydroxy-2-acetylaminofluorene and N-acetoxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; DNA; Dose-Response Relationship, Drug; Hydrolysis; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Paraoxon; Rats; Rats, Inbred F344 | 1985 |
Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
Topics: 2-Acetylaminofluorene; Animals; Female; Hydroxyacetylaminofluorene; Intracellular Membranes; Kynurenine 3-Monooxygenase; Male; Mitochondria, Liver; Mixed Function Oxygenases; Monoamine Oxidase; NADH Dehydrogenase; Rats; Rotenone; Time Factors | 1985 |
Induction of ornithine decarboxylase and augmentation of tyrosine aminotransferase activity by N-hydroxy-2-acetylaminofluorene and 2-acetylaminofluorene in rat liver. Influence of sex, retinylacetate, indomethacin, and pentachlorophenol.
Topics: 2-Acetylaminofluorene; Animals; Bucladesine; Cycloheximide; Dactinomycin; Diterpenes; Dose-Response Relationship, Drug; Enzyme Induction; Hydroxyacetylaminofluorene; Indomethacin; Liver; Male; Ornithine Decarboxylase; Pentachlorophenol; Rats; Rats, Inbred Strains; Retinyl Esters; Sex Factors; Tyrosine Transaminase; Vitamin A | 1984 |
Genesis of unusual vesicles in rat periportal hepatocytes after administration of N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Catalase; Endoplasmic Reticulum; Glucose-6-Phosphatase; Histocytochemistry; Hydroxyacetylaminofluorene; Liver; Male; Nucleotidases; Rats; Rats, Inbred Strains | 1984 |
Effect of ascorbic acid on in vitro mutagenicity and in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in the rat.
Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; DNA; Hydroxyacetylaminofluorene; Liver; Mutagens; Rats; RNA; Subcellular Fractions | 1980 |
Inhibition of sulfate conjugation of N-hydroxy-2-acetylaminofluorene in isolated perfused rat liver and in the rat in vivo by pentachlorophenol and low sulfate.
Topics: 2-Acetylaminofluorene; Animals; Chlorophenols; DNA; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Pentachlorophenol; Proteins; Rats; RNA; Sulfates | 1980 |
The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte cultures.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cells, Cultured; DNA; DNA Repair; Hydrolysis; Hydroxyacetylaminofluorene; Liver; Male; Rats; RNA | 1981 |
Sulfation in the metabolism and mutagenicity of N-hydroxy-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; DNA; Hydroxyacetylaminofluorene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Proteins; Rats; RNA; Salmonella typhimurium; Sulfates; Sulfurtransferases | 1981 |
Spin trapping of the primary radical involved in the activation of the carcinogen N-hydroxy-2-acetylaminofluorene by cumene hydroperoxide-hematin.
Topics: 2-Acetylaminofluorene; Benzene Derivatives; Chemical Phenomena; Chemistry, Physical; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Hemin; Hydroxyacetylaminofluorene; Oxidation-Reduction; Peroxides; Pyrroles; Pyrrolidinones | 1980 |
The deacetylation of N-hydroxy-2-acetylaminofluorene by rat liver microsomes and carboxyl esterase.
Topics: 2-Acetylaminofluorene; Animals; Carboxylic Ester Hydrolases; Electron Spin Resonance Spectroscopy; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Membrane Lipids; Microsomes, Liver; Nitroso Compounds; Rats | 1980 |
Free-radical events in chemical and biochemical reactions involving carcinogenic arylamines.
Topics: 2-Acetylaminofluorene; Animals; Electron Spin Resonance Spectroscopy; Enzyme Activation; Female; Fluorenes; Free Radicals; Hydroxyacetylaminofluorene; Male; Membrane Lipids; Mutagens; Neoplasms; Nitroso Compounds; Oxidation-Reduction; Peroxidases; Rats | 1981 |
Metabolism and binding of benzo(a)pyrene and 2-acetylaminofluorene by short-term organ cultures of human and rat bladder.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; Epithelium; Female; Glucuronidase; Humans; Hydroxyacetylaminofluorene; Male; Organ Culture Techniques; Rats; Urinary Bladder | 1982 |
Steroid hormone receptors in the rat mammary adenocarcinoma induced by N-hydroxy-N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Animals; Breast Neoplasms; Castration; Centrifugation, Density Gradient; Estrogens; Female; Hydroxyacetylaminofluorene; Mammary Glands, Animal; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Progesterone | 1982 |
Modulation of aromatic amine mutagenicity in Salmonella typhimurium with rat-liver 9000 g supernatant or monolayers of rat hepatocytes as an activation system.
Topics: 2-Acetylaminofluorene; Amines; Animals; Fluorenes; Hydroxyacetylaminofluorene; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship | 1983 |
Influence of conjugation reactions on the mutagenicity of aromatic amines.
Topics: 2-Acetylaminofluorene; Animals; Chemical Phenomena; Chemistry; Fluorenes; Glutathione; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Mice; Mutagenicity Tests; Mutagens; Rats; Salmonella typhimurium; Uridine Diphosphate Glucuronic Acid | 1983 |
Influence of disulfiram on mutagenicity of the urinary metabolites of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene in the Salmonella test system.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Disulfiram; Glucuronidase; Hydroxyacetylaminofluorene; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Urine | 1983 |
Effect of bacterial concentration on reversions induced in Salmonella typhimurium TA1538 by N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; DNA, Bacterial; Hydroxyacetylaminofluorene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Salmonella typhimurium | 1983 |
Modulation of genotoxic and cytotoxic effects of aromatic amines in monolayers of rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Benzoflavones; Carcinogens; Cells, Cultured; DNA; DNA Repair; Fluorenes; Galactosamine; Glutathione; Harmine; Hydroxyacetylaminofluorene; Liver; Male; Mutagens; Paraoxon; Pentachlorophenol; Pyridines; Rats; Rats, Inbred Strains; Salicylamides | 1984 |
Resistance to hepatotoxins acquired by hepatocytes during liver regeneration.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Cells, Cultured; Drug Resistance; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Methotrexate; Methyl Methanesulfonate; Rats; Rats, Inbred F344; Time Factors | 1983 |
Equilibrium binding of carcinogens and antitumor antibiotics to DNA: site selectivity, cooperativity, allosterism.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Bacteriophage phi X 174; Base Composition; Cattle; Chemical Phenomena; Chemistry; Dactinomycin; DNA; DNA, Viral; Hydroxyacetylaminofluorene; Kinetics; Nitroquinolines; Polydeoxyribonucleotides; Thymus Gland | 1981 |
Teratogenicity in vitro of two deacetylated metabolites of N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Chromatography, High Pressure Liquid; Embryo, Mammalian; Female; Fluorenes; Hydroxyacetylaminofluorene; Nitroso Compounds; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1984 |
Enhancement of the mutagenicity of carcinogenic arylamines by ethinyl estradiol.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism; Ethinyl Estradiol; Fluorenes; Hydroxyacetylaminofluorene; Male; Mammary Neoplasms, Experimental; Mestranol; Mutagens; Rats; Rats, Inbred Strains | 1984 |
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; Chemical Phenomena; Chemistry; DNA; Hydroxyacetylaminofluorene; Liver; Rats; Rats, Inbred Strains; Repetitive Sequences, Nucleic Acid | 1984 |
Heterogeneity of rat hepatocytes in transport and hepatic binding of asialoalkaline phosphatase studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Alkaline Phosphatase; Animals; Asialoglycoproteins; Bile; Biological Transport; Carbon Tetrachloride; Dogs; Glycoproteins; Histocytochemistry; Hydroxyacetylaminofluorene; Intestines; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1983 |
Metabolic activation and genotoxicity of N-hydroxy-2-acetylaminofluorene and N-hydroxyphenacetin derivatives in Reuber (H4-II-E) hepatoma cells.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Biotransformation; Cell Line; DNA Replication; Dose-Response Relationship, Drug; Guinea Pigs; Hydroxyacetylaminofluorene; Kinetics; Liver Neoplasms, Experimental; Microsomes, Liver; Phenacetin; Rabbits; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1984 |
Formation and removal of DNA adducts in rat liver treated with N-hydroxy derivatives of 2-acetylaminofluorene, 4-acetylaminobiphenyl, and 2-acetylaminophenanthrene.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; DNA; Hydroxyacetylaminofluorene; Kinetics; Liver; Male; Phenanthrenes; Phosphorus Radioisotopes; Poly dA-dT; Polydeoxyribonucleotides; Rats; Rats, Inbred Strains | 1984 |
The genotoxicity of aromatic amines in primary hepatocytes isolated from C57BL/6 and DBA/2 mice.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Biotransformation; Carcinogens; DNA; Fluorenes; Hydroxyacetylaminofluorene; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Structure-Activity Relationship | 1984 |
Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cell Survival; DNA, Bacterial; Hydroxyacetylaminofluorene; Male; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1982 |
Effects of selenium on chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Butylated Hydroxytoluene; Carcinogens; Dimethylhydrazines; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver Neoplasms; Male; Methylazoxymethanol Acetate; Mutation; Neoplasms; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Rats; Selenium; Sister Chromatid Exchange | 1980 |
Activation of certain N-arylacetamides and N-arylacetohydroxamic acids in relation to mammary gland tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Adenofibroma; Adenoma; Animals; Biotransformation; Carcinogens; Cytochromes; Female; Hydroxyacetylaminofluorene; Mammary Neoplasms, Experimental; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Rats; Structure-Activity Relationship | 1981 |
Effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on the cellular levels of epoxide hydratase, cytochrome P-450b, and NADPH-cytochrome c (P-450) oxidoreductase messenger ribonucleic acids.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Hydroxyacetylaminofluorene; Kinetics; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1982 |
Morphological studies on selective acinar liver damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Histocytochemistry; Hydroxyacetylaminofluorene; Liver; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 1983 |
Heterogeneity of rat hepatocytes in bile acid and DBSP transport studied after induction of selective acinar damage by N-hydroxy-2-acetylaminofluorene and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Animals; Bile Acids and Salts; Biological Transport; Bromthymol Blue; Carbon Tetrachloride; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Thymol | 1983 |
Formation and persistence of DNA adducts from the carcinogen N-hydroxy-2-acetylaminofluorene in rat mammary gland in vivo.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Biotransformation; DNA; Epithelium; Female; Hydroxyacetylaminofluorene; Kinetics; Mammary Glands, Animal; Rats; Rats, Inbred Strains; Tritium | 1983 |
Mutagenicity of N-hydroxy-2-acetylaminofluorene and N-hydroxy-phenacetin and their respective deacetylated metabolites in nitroreductase deficient Salmonella TA98FR and TA100FR.
Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Cricetinae; Hydroxyacetylaminofluorene; Male; Mesocricetus; Microsomes, Liver; Mutagenicity Tests; Mutation; Nitro Compounds; Nitroreductases; Oxidoreductases; Phenacetin; Rats; Rats, Inbred Strains; Salmonella | 1982 |
Mutagenic activation of N-2-fluorenylacetamide and N-hydroxy-N-2-fluorenylacetamide in subcellular fractions from X/Gf mice.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Enzyme Induction; Hydroxyacetylaminofluorene; Kidney; Mice; Microsomes; Microsomes, Liver; Mutagens; Paraoxon; Subcellular Fractions | 1980 |
Factors influencing the binding of N-2-fluorenylacetamide to specific regions of the hepatic genome in vivo in rats.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Chromatin; Deoxyribonucleases; DNA; Genes; Hydroxyacetylaminofluorene; Liver; Magnesium; Magnesium Chloride; Male; Rats | 1981 |
Mechanism of N-hydroxy-2-acetylaminofluorene mutagenicity in the Salmonella test system. Role of N-O acyltransferase and sulfotransferase from rat liver.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Cytosol; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Mutagens; Rats; RNA, Transfer; Salmonella; Sulfotransferases; Sulfurtransferases | 1981 |
Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Acyltransferases; Amidohydrolases; Animals; Biotransformation; Cricetinae; Cytosol; Guinea Pigs; Hydroxyacetylaminofluorene; Liver; Macaca; Male; Microsomes, Liver; Paraoxon; Rats; Species Specificity | 1981 |
Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; DNA; Female; Hydroxyacetylaminofluorene; Kidney; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sulfurtransferases | 1982 |
Sulfotransferase and deacetylase in normal and tumor-bearing liver of CD rats: autoradiographical studies with N-hydroxy-2-acetylaminofluorene and N-hydroxy-4-acetylaminobiphenyl in vitro and in vivo.
Topics: 2-Acetylaminofluorene; Amidohydrolases; Aminobiphenyl Compounds; Animals; Autoradiography; Chemical and Drug Induced Liver Injury; Female; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms, Experimental; Male; Paraoxon; Rats; Sulfates; Sulfurtransferases | 1982 |
Detection of N-hydroxy-2-acetylaminofluorene-DNA adducts in rat liver measured by radioimmunoassay.
Topics: 2-Acetylaminofluorene; Animals; Antibody Formation; Antibody Specificity; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Injections, Intraperitoneal; Liver; Male; Methods; Radioimmunoassay; Rats; Rats, Inbred Lew | 1982 |
Effects of structure of N-acyl-N-2-fluorenylhydroxylamines on arylhydroxamic acid acyltransferase, sulfotransferase, and deacylase activities, and on mutations in Salmonella typhimurium TA 1538.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Acyltransferases; Amidohydrolases; Animals; Enzyme Activation; Female; Guinea Pigs; Hydroxyacetylaminofluorene; In Vitro Techniques; Male; Microsomes, Liver; Mutagens; Rats; RNA, Transfer; Salmonella typhimurium; Structure-Activity Relationship; Sulfurtransferases | 1980 |
Bacterial mutagenesis and host cell DNA damage by chemical carcinogens in the Salmonella/hepatocyte system.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Fluorenes; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Mutation; Rats; Salmonella typhimurium | 1980 |
Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat.
Topics: 2-Acetylaminofluorene; Animals; Carbon Radioisotopes; Glutathione; Hydroxyacetylaminofluorene; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Tritium | 1982 |
Effects of prolonged oral treatment with N-fluoren-4-ylacetohydroxamic acid on rat liver fine structure.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Endoplasmic Reticulum; Hydroxyacetylaminofluorene; Liver; Liver Neoplasms; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 1982 |
Rat mammary gland carcinogenesis after local injection of N-hydroxy-N-acyl-2-aminofluorenes: relationship to metabolic activation.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Acyltransferases; Adenocarcinoma; Adenofibroma; Animals; Biotransformation; Cytosol; Female; Hydroxamic Acids; Hydroxyacetylaminofluorene; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Microsomes; Mutagenicity Tests; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1982 |
Metabolism of N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene by guinea pig liver microsomes.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Chromatography, Gas; Fluorenes; Guinea Pigs; Hydroxyacetylaminofluorene; Hydroxylation; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases | 1982 |
Genetic differences in the enzymic properties of the aromatic hydrocarbon inducible N-hydroxylation of 2-acetylaminofluorene in mouse liver.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Guinea Pigs; Hydroxyacetylaminofluorene; Hydroxylation; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Species Specificity | 1982 |
Prevention of the hepatotoxic action of N-hydroxy-2-acetylaminofluorene in the rat by inhibition of N-O-sulfation by pentachlorophenol.
Topics: 2-Acetylaminofluorene; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chlorophenols; Female; Hydroxyacetylaminofluorene; Liver; Pentachlorophenol; Rats; Sulfates | 1981 |
Effect of the structural isomer N-3-fluorenylacetamide on microsomal binding and hydroxylation of the carcinogen N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Hydroxyacetylaminofluorene; Hydroxylation; In Vitro Techniques; Isomerism; Male; Microsomes, Liver; NADP; Propylene Glycol; Propylene Glycols; Proteins; Rats | 1981 |
Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by pentachlorophenol.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Chlorophenols; Depression, Chemical; DNA; Hydroxyacetylaminofluorene; Liver; Male; Pentachlorophenol; Rats; Rats, Inbred Strains; Sulfates | 1981 |
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.
Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chromatography, High Pressure Liquid; Cricetinae; Hydroxamic Acids; Hydroxyacetylaminofluorene; Male; Mesocricetus; Microsomes, Liver; Phenacetin; Spectrophotometry; Structure-Activity Relationship | 1980 |
New 9-stubstituted 3-N,O-diacetylhydroxylaminofluorenes: enhanced electrophilicity and mutagenicity. Derivatives of fluorene. 38.
Topics: 2-Acetylaminofluorene; Animals; Chemical Phenomena; Chemistry; Hydroxyacetylaminofluorene; Mutagens; Rats; Structure-Activity Relationship | 1980 |
Inhibition of RNA polymerase III by N-hydroxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DNA-Directed RNA Polymerases; Hydroxyacetylaminofluorene; Liver; Male; Rats; RNA Polymerase III | 1980 |
Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes.
Topics: 2-Acetylaminofluorene; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hydroxyacetylaminofluorene; In Vitro Techniques; Liver; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rabbits; Rats; Species Specificity | 1980 |
Acyltransferase-mediated binding of N-hydroxyarylamides to nucleic acids.
Topics: 2-Acetylaminofluorene; Acyltransferases; Animals; Biotransformation; DNA; Female; Guinea Pigs; Humans; Hydroxyacetylaminofluorene; Liver; Macaca mulatta; Male; Papio; Rats; Substrate Specificity; Swine | 1980 |
Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Cytosol; Down-Regulation; Hydroxyacetylaminofluorene; Immunohistochemistry; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; Rats, Sprague-Dawley | 1994 |
Acute and chronic toxicity of aromatic amines studied in the isolated perfused rat liver.
Topics: 2-Acetylaminofluorene; Amines; Animals; Carcinogens; Glutathione; Hemostatics; Hydroxyacetylaminofluorene; Isotope Labeling; Liver; Male; Mitochondria, Liver; Oxygen Consumption; Perfusion; Phenanthrenes; Rats; Rats, Wistar; Reactive Oxygen Species; Stilbenes; Vitamin K | 1996 |
Pseudoenzymatic reduction of N-hydroxy-2-acetylaminofluorene to 2-acetylaminofluorene mediated by cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cytochrome P-450 CYP2B1; Hydroxyacetylaminofluorene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Rats | 1999 |
The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Topics: 2-Acetylaminofluorene; Animals; Bacterial Proteins; Biotransformation; Catalysis; Cell Line; Cytochrome P-450 CYP1A2; DNA-Directed DNA Polymerase; Escherichia coli Proteins; Gene Expression Regulation, Enzymologic; Glucuronides; Glucuronosyltransferase; Humans; Hydroxyacetylaminofluorene; Hydroxylation; Imidazoles; Isoenzymes; Mice; Mutagenicity Tests; Mutagens; Pyridines; Recombinant Proteins | 2001 |
Induction of -2 frameshift mutations by 2-nitrofluorene, N-hydroxyacetylaminofluorene, and N-2-acetylaminofluorene in reversion assays in Escherichia coli strains differing in permeability and acetyltransferase activity.
Topics: 2-Acetylaminofluorene; Acetyltransferases; Alleles; Escherichia coli; Fluorenes; Frameshift Mutation; Hydroxyacetylaminofluorene; Lac Operon; Permeability | 2001 |
Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Crosses, Genetic; Disease Models, Animal; DNA Primers; DNA Repair; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Genotype; Heterozygote; Homozygote; Humans; Hydroxyacetylaminofluorene; Lung Neoplasms; Male; Mice; Mice, Knockout; Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2003 |
RAT LIVER AFTER N-HYDROXY-2-ACETYLAMINOFLUORENE. ULTRASTRUCTURE.
Topics: 2-Acetylaminofluorene; Carcinogens; Chemical and Drug Induced Liver Injury; Electrons; Endoplasmic Reticulum; Fluorenes; Hepatitis; Hydroxyacetylaminofluorene; Liver; Microscopy; Microscopy, Electron; Mitochondria; Pathology; Rats; Research; Toxicology | 1965 |
Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models.
Topics: 2-Acetylaminofluorene; Carcinogens; DNA Adducts; DNA Damage; Fluorenes; Humans; Hydroxyacetylaminofluorene; Micronucleus Tests; Mutagens; Skin | 2021 |