2-acetylaminofluorene has been researched along with dimethylnitrosamine in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (71.15) | 18.7374 |
| 1990's | 9 (17.31) | 18.2507 |
| 2000's | 3 (5.77) | 29.6817 |
| 2010's | 3 (5.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Chu, BC; Lawley, PD | 1 |
| Matsushima, T; Sugimura, T | 1 |
| Ichinotsubo, D; Mandel, M; Mower, H | 1 |
| Chopra, P; Manga, A; Nayak, NC | 1 |
| Williams, GM | 1 |
| San, RH; Williams, GM | 1 |
| Friedman, MA | 1 |
| Buckley, JD; Craig, AW; O'Connor, PJ | 1 |
| Heidelberger, C; Lillehaug, JR; Mondal, S | 1 |
| Sidransky, H; Verney, E | 1 |
| Michalopoulos, G; O'Connor, L; Pitot, HC; Sattler, GL | 1 |
| Friedman, MA; Staub, J | 1 |
| Farber, E; Gruenstein, M; Parker, S | 1 |
| Farber, E; Klaiber, M; Parker, SE; Williams, GM | 1 |
| Becker, FF | 1 |
| Ashby, J; Lefevre, PA | 1 |
| Blankenship, LJ; Clawson, GA; Rhame, JG; Wilkinson, DS | 1 |
| Aaron, CS; Grzegorczyk, CR; Harbach, PR; Smith, AL; Wiser, SK | 2 |
| Majeska, JB; Matheson, DW | 1 |
| Furihata, C; Matsushima, T; Sawada, S | 1 |
| Bradbrook, C; Charlesworth, JD; Chu, YH; Cooper, DP; Margison, GP; O'Connor, PJ; Styles, J | 1 |
| Chevalier, G; Cote, MG; Denizeau, F; Marion, M | 1 |
| Doolittle, DJ; Muller, G; Scribner, HE | 1 |
| Clawson, GA; Ferrell, LD; Moody, DE; Smuckler, EA | 1 |
| Emmelot, P; Scherer, E | 1 |
| Bliznakov, EG; Guttenplan, JB | 1 |
| Bresil, H; Cooper, DP; Margison, GP; Montesano, R; O'Connor, PJ; Planche-Martel, G; Smith, RA | 1 |
| Castonguay, A; Schut, HA | 1 |
| Gutmann, HR; Smith, BA | 1 |
| Digernes, V | 1 |
| Imaida, K; Ito, N; Shirai, T; Takano, T; Tatematsu, M | 1 |
| Clawson, GA; Smuckler, EA | 1 |
| Furukawa, K; Gotoh, M; Mochizuki, Y; Sawada, N; Tsukada, H | 1 |
| Igel, HJ; Kropko, ML; Lake, RS; McLachlan, S; Pezzutti, MR; Shoemaker, RH | 1 |
| Lotlikar, PD | 1 |
| Charlesworth, JD; Chu, YH; Craig, AW; O'Connor, PJ | 1 |
| Becker, FF; Stout, DL | 1 |
| Hemminki, K; Savolainen, H | 1 |
| Chandra, P; Nashed, N | 1 |
| Casciano, DA; Chou, MW; Feuers, RJ; Pegram, RA; Shaddock, JG | 1 |
| Casciano, DA; Chou, MW; Feuers, RJ; Shaddock, JG | 1 |
| Galloway, SM; Johnson, TE; Umbenhauer, DR | 1 |
| Ludwicki, JK; Tyrkiel, E; Wiadrowska, B | 1 |
| Ashby, J; Lefevre, PA; Tinwell, H | 1 |
| Edwards, AJ; Lake, BG; Price, RJ; Renwick, AB | 1 |
| Butterworth, BE; Mirsalis, JC | 1 |
| Adams, TB; Beamand, JA; Edwards, AJ; Lake, BG; Phillips, BJ; Price, RJ; Renwick, AB | 1 |
| Chagnon, MC; Le Bon, AM; Le Hegarat, L; Lhuguenot, JC; Valentin-Severin, I | 1 |
| Fujiishi, Y; Hamada, S; Hattori, A; Kawabata, M; Kawasako, K; Nakadate, K; Nakagawa, M; Narumi, K; Ohyama, W; Okada, E; Takasawa, H; Takashima, R; Wako, Y; Yasunaga, K | 1 |
| Boyle, MH; Hobbs, CA; Recio, L; Shiga, A; Streicker, M; Tanaka, J; Witt, KL | 1 |
5 review(s) available for 2-acetylaminofluorene and dimethylnitrosamine
| Article | Year |
|---|---|
Experimental carcinogenesis in small aquarium fishes.
Topics: 2-Acetylaminofluorene; Adenoma; Adenoma, Bile Duct; Aflatoxins; Animals; Benzopyrenes; Carcinogens; Carcinoma, Hepatocellular; Cycasin; Diethylnitrosamine; Dimethylnitrosamine; Female; Fishes; Goldfish; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Sterigmatocystin; Trout | 1976 |
Methylated purines formed in DNA by dimethylnitrosamine in rats previously exposed to hepatotoxic and hepatocarcinogenic regimes: effects on the repair of O6-methylguanine.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Dimethylnitrosamine; DNA; DNA Repair; Ethanolamines; Guanine; Liver; Male; Quinoxalines; Rats; Rats, Inbred Strains | 1985 |
The first relevant cell stage in rat liver carcinogenesis. A quantitative approach.
Topics: 2-Acetylaminofluorene; Animals; Basophils; Carcinoma, Hepatocellular; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hepatectomy; Histocytochemistry; Immunogenetics; Kinetics; Liver; Liver Glycogen; Liver Neoplasms; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors | 1980 |
Enhanced repair of O6-alkylguanine in mammalian tissues.
Topics: 2-Acetylaminofluorene; Adenine; Aflatoxin B1; Aflatoxins; Alkylating Agents; Alkylation; Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Hepatectomy; Liver; Methylnitrosourea; Mice; Rats; Rodentia; Species Specificity | 1984 |
Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; 2-Naphthylamine; Alkylation; Amines; Aminobiphenyl Compounds; Animals; Benzidines; Carcinogens; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; DNA; Guinea Pigs; Humans; Methyldimethylaminoazobenzene; Mice; Nicotiana; Nitrosamines; p-Dimethylaminoazobenzene; Plants, Toxic; Rats; Species Specificity | 1984 |
47 other study(ies) available for 2-acetylaminofluorene and dimethylnitrosamine
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Increased urinary excretion of nucleic acid and nicotinamide derivatives by rats after treatment with alkylating agents.
Topics: 2-Acetylaminofluorene; Alkylating Agents; Animals; Benz(a)Anthracenes; Busulfan; Chromatography, Thin Layer; Cytarabine; Deoxycytidine; Dichlorvos; Dimethylnitrosamine; Ethyl Methanesulfonate; Female; Fluorouracil; Hydrocarbons, Brominated; Mechlorethamine; Methylguanidine; Niacinamide; Nitrosourea Compounds; Rats; Thymidine; Uric Acid | 1975 |
Nitroso group exchange as a way of activation of nitrosamines by bacteria.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Dimethylnitrosamine; DNA, Bacterial; Drug Synergism; Escherichia coli; Fluorenes; Nitrosamines | 1977 |
Kupffer cell sarcoma in rats after exposure to small doses of dimethylnitrosamine and N-2-acetylaminofluorene during hepatic regeneration.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Fluorenes; Liver Neoplasms; Liver Regeneration; Lymphoma, Large B-Cell, Diffuse; Male; Microscopy, Electron; Nitrosamines; Rats; Sarcoma, Experimental | 1979 |
Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Benz(a)Anthracenes; Carcinogens; Cells, Cultured; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Drug Evaluation, Preclinical; Hydroxyurea; Liver; Methyldimethylaminoazobenzene; Methylnitronitrosoguanidine; p-Aminoazobenzene | 1977 |
Rat hepatocyte primary cell culture-mediated mutagenesis of adult rat liver epithelial cells by procarcinogens.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Biotransformation; Carcinogens; Cells, Cultured; Dimethylnitrosamine; Liver; Mutagens | 1977 |
Subchronic effects of piperonyl butoxide on carcinogen metabolism in hamster liver.
Topics: 2-Acetylaminofluorene; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cricetinae; Dimethylnitrosamine; Hydroxylation; In Vitro Techniques; Liver; Mesocricetus; Methyltransferases; Mixed Function Oxygenases; Oxidoreductases; Piperonyl Butoxide; Time Factors | 1979 |
Pretreatment with acetylaminofluorene enhances the repair of O6-methylguanine in DNA.
Topics: 2-Acetylaminofluorene; Animals; Deoxyguanine Nucleotides; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Male; Methylation; Rats | 1979 |
Establishment of epithelial cell lines from adult mouse regenerating liver.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Cell Division; Cell Line; Chromosomes; Clone Cells; Dimethylnitrosamine; Diploidy; Epithelium; Liver; Liver Regeneration; Methylcholanthrene; Mice | 1979 |
Acute effects of selected hepatocarcinogens on polyribosomes and protein synthesis in the livers of rats fed purified diets containing hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Carcinogens; Diet; Dimethylnitrosamine; Ethionine; Female; Liver; Methyldimethylaminoazobenzene; Polyribosomes; Protein Biosynthesis; Rats; Thioacetamide; Time Factors | 1978 |
Unscheduled DNA synthesis induced by procarcinogens in suspensions and primary cultures of hepatocytes on collagen membranes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Collagen; Culture Media; Dimethylnitrosamine; DNA; Drug Evaluation, Preclinical; Hydroxyurea; In Vitro Techniques; Liver; Methyldimethylaminoazobenzene; Mutagens; Rats | 1978 |
Induction of micronuclei in mouse and hamster bone-marrow by chemical carcinogens.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Bone Marrow; Bone Marrow Cells; Cell Nucleus; Cricetinae; Dimethylnitrosamine; Erythrocytes; Female; Fluorenes; Injections, Intraperitoneal; Male; Methylcholanthrene; Mice; Nitrosamines | 1977 |
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Cell Transformation, Neoplastic; Dimethylnitrosamine; DNA; Drug Resistance; Ethionine; Hyperplasia; Liver; Liver Neoplasms; Male; Precancerous Conditions; Proteins; Rats; Rats, Inbred F344; RNA | 1976 |
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; Hyperplasia; Iron; Liver Neoplasms; Male; Mitosis; Neoplasms, Experimental; Precancerous Conditions; Rats | 1976 |
Sequential phenotypic and biochemical alterations during chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cell Aggregation; Chromatin; Dimethylnitrosamine; Lectins; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimental; Phenotype; Precancerous Conditions; Rats; Rats, Inbred ACI | 1976 |
Mitogenesis, micronuclei, and carcinogenesis in the rat liver: some basic inconsistencies.
Topics: 2-Acetylaminofluorene; Animals; Clofenapate; Dimethylnitrosamine; Hepatectomy; Liver; Male; Micronucleus Tests; Mitosis; Neoplasms, Experimental; Rats | 1992 |
Nuclear enlargement induced by hepatocarcinogens alters ploidy.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Dimethylnitrosamine; Diploidy; Liver; Male; Polyploidy; Rats; Rats, Inbred Strains; Thioacetamide | 1992 |
Strain differences in in vitro rat hepatocyte unscheduled DNA synthesis (UDS): effect of UV is independent of strain while increased sensitivity is apparent using Fischer-344 instead of Sprague-Dawley rats.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Benzidines; Dimethylnitrosamine; DNA; DNA Repair; Liver; Male; Methylnitronitrosoguanidine; Mutagenicity Tests; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity; Ultraviolet Rays | 1991 |
Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cyclophosphamide; Dimethylnitrosamine; Lymphoma; Methylcholanthrene; Mice; Microsomes, Liver; Mutagenicity Tests; NADP; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 1990 |
In vivo short-term assays of repair and replication of rat liver DNA.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Liver; Male; Rats; Rats, Inbred F344 | 1989 |
The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes. Validation of improved methods for primary culture including data on the lack of effect of ionizing radiation.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Collagen; Diethylnitrosamine; Dimethylnitrosamine; DNA Replication; Liver; Male; Methyl Methanesulfonate; Rats; Rats, Inbred F344; Rats, Inbred Strains; Ultraviolet Rays; X-Rays | 1989 |
Genotoxicity of dimethylnitrosamine in the presence of chrysotile asbestos UICC B and xonotlite.
Topics: 2-Acetylaminofluorene; Animals; Asbestos; Asbestos, Serpentine; Calcium Compounds; Carcinogens; Dimethylnitrosamine; DNA Replication; Drug Interactions; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Rats; Silicates; Silicic Acid; Silicon Dioxide | 1985 |
The in vivo-in vitro hepatocyte assay for assessing DNA repair and DNA replication: studies in the CD-1 mouse.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; DNA Repair; DNA Replication; Interphase; Liver; Liver Neoplasms, Experimental; Male; Mice | 1987 |
Increased nucleoside triphosphatase activity of rat liver nuclear envelope is associated with hepatocarcinogen exposure.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Biological Transport; Carbon Tetrachloride Poisoning; Carcinogens; Dimethylnitrosamine; Kinetics; Liver; Male; Methyldimethylaminoazobenzene; Nuclear Envelope; Nucleoside-Triphosphatase; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Inbred Strains; RNA; Thioacetamide | 1984 |
Activation of promutagens by liver homogenates isolated from female mice at different ages; lack of significant differences.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Dimethylnitrosamine; Female; Liver; Mice; Mutagenicity Tests; Mutagens; Salmonella typhimurium | 1981 |
Differential effect of chronic ethanol consumption by the rat on microsomal oxidation of hepatocarcinogens and their activation to mutagens.
Topics: 2-Acetylaminofluorene; Alcoholism; Animals; Biotransformation; Dimethylnitrosamine; Eating; Humans; Male; Microsomes, Liver; Mutagens; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1984 |
Chemical liver carcinogenesis: monitoring of the process by flow cytometric DNA measurements.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Clone Cells; Dimethylnitrosamine; DNA, Neoplasm; Flow Cytometry; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Ploidies; Rats | 1983 |
Dose responses of five hepatocarcinogens for the initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Dose-Response Relationship, Drug; Hepatectomy; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; p-Dimethylaminoazobenzene; Rats | 1981 |
Increased amounts of double-stranded RNA in the cytoplasm of rat liver following treatment with carcinogens.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cytoplasm; Dimethylnitrosamine; Liver; Male; Rats; Rats, Inbred Strains; RNA, Double-Stranded | 1982 |
Primary culture of preneoplastic hepatocytes from rats treated with 2-acetylaminofluorene and clofibrate: relationship between resistance to dimethylnitrosamine and responsiveness of peroxisomes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Clofibrate; Dimethylnitrosamine; Drug Resistance; Liver Neoplasms, Experimental; Male; Microbodies; Microscopy, Electron; Organoids; Precancerous Conditions; Rats; Rats, Inbred Strains | 1982 |
Chemical carcinogen induction of DNA-repair synthesis in human peripheral blood monocytes.
Topics: 2-Acetylaminofluorene; Aflatoxins; Benzopyrenes; Carcinogens; Cells, Cultured; Dimethylnitrosamine; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mitomycins; Monocytes; Mutagens | 1980 |
Metabolic activation of aromatic amines and dialkylnitrosamines.
Topics: 2-Acetylaminofluorene; Amines; Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Dealkylation; Diethylnitrosamine; Dimethylnitrosamine; Female; Guinea Pigs; Hydroxylation; Male; Mice; Nitrosamines; Rats | 1981 |
Effect of pretreatment by feeding acetylaminofluorene on methylated purines formed in rat liver DNA after administration of dimethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Diet; Dimethylnitrosamine; DNA; DNA-Directed DNA Polymerase; Growth; Liver; Male; Purines; Rats; Rats, Inbred Strains; Thymidine | 1981 |
Progressive DNA damage in hepatic nodules during 2-acetylaminofluorene carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dimethylnitrosamine; DNA, Neoplasm; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Rats; Time Factors | 1980 |
Alkylation of rat serum proteins by dimethylnitrosamine and acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Alkylation; Animals; Blood Proteins; Dimethylnitrosamine; Rats | 1980 |
An in vivo-in vitro short term carcinogenicity test using rat peritoneal cells.
Topics: 2-Acetylaminofluorene; Animals; Ascitic Fluid; Carcinogens; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Rats | 1980 |
Effects of aging and caloric restriction on the genotoxicity of four carcinogens in the in vitro rat hepatocyte/DNA repair assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aging; Animals; Dimethylnitrosamine; DNA Repair; Energy Intake; Food Deprivation; Liver; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred F344 | 1993 |
Evidence that DNA repair may not be modified by age or chronic caloric restriction.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Aging; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Diet; Dimethylnitrosamine; DNA; DNA Repair; Energy Intake; Enzyme Induction; Food Deprivation; Liver; Male; Mixed Function Oxygenases; Mutagens; Rats; Rats, Inbred F344 | 1993 |
Human liver S-9 metabolic activation: proficiency in cytogenetic assays and comparison with phenobarbital/beta-naphthoflavone or aroclor 1254 induced rat S-9.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chlorodiphenyl (54% Chlorine); CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Humans; Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1996 |
[The effect of nuarimol on the mutagenic activity of n-nitrosodimethylamine and 2-acetylaminofluorene in mouse erythrocytes].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Dimethylnitrosamine; Drug Administration Schedule; Drug Interactions; Erythrocytes; Fungicides, Industrial; Male; Mice; Mice, Inbred Strains; Micronucleus Tests; Mutagens; Pyrimidines | 1998 |
Relative activities of methyl methanesulphonate (MMS) as a genotoxin, clastogen and gene mutagen to the liver and bone marrow of MutaMouse mice.
Topics: 2-Acetylaminofluorene; Animals; Bone Marrow; Dimethylnitrosamine; DNA Damage; Liver; Male; Methyl Methanesulfonate; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Transgenic; Micronucleus Tests; Mutagenicity Tests; Mutagens | 1998 |
Lack of effect of coumarin on unscheduled DNA synthesis in the in vivo rat hepatocyte DNA repair assay.
Topics: 2-Acetylaminofluorene; Animals; Anticoagulants; Cell Separation; Cells, Cultured; Coumarins; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Liver; Male; Mutagens; Rats; Rats, Sprague-Dawley | 2000 |
Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens.
Topics: 2-Acetylaminofluorene; Animals; Autoradiography; Carbon Tetrachloride; Carcinogens; Cell Nucleus; Cytoplasm; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Hepatocytes; Kinetics; Male; Mutagens; Rats; Rats, Inbred F344; Thymidine; Tritium | 1980 |
Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cells, Cultured; Dimethylnitrosamine; DNA; DNA Repair; DNA Replication; Female; Furaldehyde; Hepatocytes; Humans; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred Strains; o-Aminoazotoluene; Rats; Rats, Inbred F344 | 2001 |
Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Benzo(a)pyrene; Carcinoma, Hepatocellular; Comet Assay; Dimethylnitrosamine; Humans; Inhibitory Concentration 50; Liver Neoplasms; Methyl Methanesulfonate; Micronucleus Tests; Mutagens; Nitrosamines; Quinolones; Sensitivity and Specificity; Tumor Cells, Cultured | 2003 |
Evaluation of a repeated dose liver micronucleus assay in rats treated with two genotoxic hepatocarcinogens, dimethylnitrosamine and 2-acetylaminofluorene: the possibility of integrating micronucleus tests with multiple tissues into a repeated dose genera
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Bone Marrow; Carcinogens; Chromosome Aberrations; Cooperative Behavior; Dimethylnitrosamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Gastrointestinal Tract; Hepatocytes; Humans; Japan; Liver; Male; Micronucleus Tests; Organ Specificity; Rats; Rats, Sprague-Dawley; Societies, Pharmaceutical | 2015 |
Comet assay evaluation of six chemicals of known genotoxic potential in rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Administration, Oral; Aniline Compounds; Animals; Arsenites; Carcinogens; Comet Assay; Dimethylnitrosamine; DNA Damage; DNA Fragmentation; Dose-Response Relationship, Drug; Liver; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sodium Chloride; Sodium Compounds; Stomach | 2015 |