2-acetylaminofluorene has been researched along with deoxyguanosine in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (41.10) | 18.7374 |
| 1990's | 23 (31.51) | 18.2507 |
| 2000's | 14 (19.18) | 29.6817 |
| 2010's | 6 (8.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dubin, MA; Poirier, MC; Yuspa, SH | 1 |
| Kriek, E; Spelt, CE | 1 |
| Beland, FA | 1 |
| Blobstein, S; Poirier, MC; Weinstein, IB; Yuspa, SH | 1 |
| Casciano, DA | 1 |
| Beland, FA; Meerman, JH; Mulder, GJ; Timmers-Reker, AJ; Wedzinga, R; Wierckx, FC | 1 |
| Brandtzaeg, P; Huitfeldt, HS; Poirier, MC | 1 |
| Gentles, R; Grollman, AP; Johnson, F; Shibutani, S | 1 |
| Gupta, PK; King, CM; Lee, MS; Pandrangi, RG | 1 |
| Annan, RS; Giese, RW; Vouros, P | 1 |
| Beland, FA; Fullerton, NF; Marques, MM; Melchior, WB; Poirier, MC; Smith, BA | 1 |
| Beland, FA; Fullerton, NF; Kinouchi, T; Poirier, MC; Smith, BA | 1 |
| Retèl, J; van Grondelle, R; van Houte, LP; Westra, JG | 1 |
| Baron, J; Huitfeldt, HS; Poirier, MC; Spangler, EF | 1 |
| Gupta, PK; Johnson, DL; King, CM; Lee, MS; Reid, TM; Romano, LJ | 1 |
| Meerman, JH; Mulder, GJ; Tates, AD; van de Poll, ML; van der Hulst, DA | 1 |
| Geacintov, NE; Kim, SK; Retèl, J; Sutherland, JC; van Grondelle, R; van Houte, LP; Westra, JG; Zinger, D | 1 |
| Abuaf, P; Broyde, S; Grunberger, D; Hingerty, BE; Live, D; Norman, D; Patel, DJ | 1 |
| Huitfeldt, HS; Hunt, JM; Pitot, HC; Poirier, MC | 1 |
| Evans, FE; Levine, RA | 2 |
| Arce, GT; Cline, DT; Mead, JE | 1 |
| Lai, CC; Liem, A; Miller, EC; Miller, JA | 1 |
| Den Engelse, L; Hermsen, T; Kriek, E; Menkveld, GJ; Scherer, E; Van der Laken, CJ | 1 |
| Duker, NJ; Merkel, GW | 1 |
| Daune, MP; Fuchs, RP; Koffel-Schwartz, N; Westhof, E | 1 |
| Metzger, G; Ross, J; Werbin, H | 1 |
| Duker, NJ; Hart, DM | 1 |
| Broyde, S; Hingerty, B | 2 |
| Bazgar, S; Leng, M; Rio, P | 1 |
| Beland, FA; Chevalier, T; Lipkowitz, KB; Widdifield, M | 1 |
| Hagenaars, AM; Hermsen, G; Kriek, E; Kuipers, AJ; Nagel, J; Scherer, E; Van Der Laken, CJ; Welling, M | 1 |
| Connor, RJ; Poirier, MC | 1 |
| Evans, FE; Miller, DW | 1 |
| Kriek, E; Westra, JG | 1 |
| Poirier, MC; Williams, GM; Yuspa, SH | 1 |
| Doisy, R; Tang, MS | 1 |
| Beland, FA; Marques, MM; Melchior, WB | 1 |
| Giese, RW; Vouros, P | 1 |
| Romano, LJ; Zhou, Y | 1 |
| Beland, FA; Culp, SJ; Poirier, MC | 1 |
| Coin, F; Fuchs, RP; Koffel-Schwartz, N; Veaute, X | 1 |
| Fuchs, RP; Kamiya, H; Wagner, J | 1 |
| Downey, KM; Fisher, PA; Mozzherin, DJ; Shibutani, S; Tan, CK | 1 |
| Beland, FA; Marques, MM; Melchior, WB; Mourato, LL; Santos, MA | 1 |
| Bol, SA; de Groot, AJ; Meerman, JH; Mullenders, LH; Tijdens, RB; van Zeeland, AA | 1 |
| de Groot, AJ; Filon, R; Mullenders, LH; van Oosterwijk, MF; van Zeeland, AA | 1 |
| Grollman, AP; Shibutani, S; Suzuki, N | 1 |
| Cho, BP; Zhou, L | 1 |
| Basu, AK; Broyde, S; Gorin, A; Gu, Z; Hingerty, BE; Krishnasamy, R; Patel, DJ | 1 |
| Guo, D; Rajpal, DK; Taylor, JS; Wang, M; Wang, Z; Wu, X; Yuan, F; Zhang, Y | 1 |
| Besson, M; Mihalek, CL | 1 |
| Grunberger, D; Kriek, E; Santella, RM | 1 |
| Beland, FA; Evans, FE; Miller, DW | 1 |
| Grollman, AP; Johnson, F; Shibutani, S; Suzuki, N; Tan, X | 1 |
| Grollman, AP; Hayashi, K; Ohashi, E; Ohmori, H; Shibutani, S; Suzuki, N | 1 |
| Hara, R; Sancar, A | 2 |
| Kawanishi, S; Murata, M; Tada, M; Yoshiki, Y | 1 |
| Grollman, AP; Shibutani, S; Suzuki, N; Tan, X | 1 |
| Guo, D; Shen, H; Wang, Z; Xie, Z; Zhao, B | 1 |
| Bonala, RR; Dong, H; Grollman, AP; Hanaoka, F; Johnson, F; Ohmori, H; Shibutani, S; Suzuki, N; Yasui, M | 1 |
| Alzeer, J; Gillet, LC; Schärer, OD | 1 |
| Chan, PY; Chiu, P; Kwok, WM; Lam, SK; Phillips, DL | 1 |
| Broyde, S; Wang, L | 1 |
| Broyde, S; Donny-Clark, K; Shapiro, R | 1 |
| Carell, T; Schorr, S | 1 |
| Chiarelli, MP; Cho, BP; Hilton, B; Jain, V; Patnaik, S; Zou, Y | 1 |
| Broyde, S; Geacintov, NE; Kolbanovskiy, A; Kolbanovskiy, M; Kropachev, K; Mu, H; Wang, L; Zhang, L | 1 |
| Cho, BP; Darian, E; Hilton, B; Jain, V; Liang, F; Lin, B; Mackerell, AD; Patnaik, S; Zou, Y | 1 |
| Markiewicz, RP; Romano, LJ; Rueda, D; Vrtis, KB | 1 |
| Broyde, S; Ding, S; Geacintov, NE; Lior-Hoffmann, L; Zhang, Y | 1 |
73 other study(ies) available for 2-acetylaminofluorene and deoxyguanosine
| Article | Year |
|---|---|
Formation and removal of specific acetylaminofluorene-DNA adducts in mouse and human cells measured by radioimmunoassay.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetylation; Animals; Cells, Cultured; Deoxyguanosine; DNA; Fluorenes; Humans; Mice; Radioimmunoassay; Skin | 1979 |
Differential excision from DNA of the C-8 deoxyguanosine reaction products of N-hydroxy-2-aminofluorene and N-acetoxy-N-acetyl-2-aminofluorene by endonuclease S1 from Aspergillus oryzae.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Aspergillus oryzae; Deoxyguanosine; DNA; Endonucleases; Fluorenes; Hydroxylamines; Kinetics; Nucleic Acid Conformation; Nucleic Acid Denaturation | 1979 |
Computer-generated graphic models of the N2-substituted deoxyguanosine adducts of 2-acetylaminofluorene and benzo[a]pyrene and the O6-substituted deoxyguanosine adduct of 1-naphthylamine in the DNA double helix.
Topics: 1-Naphthylamine; 2-Acetylaminofluorene; Benzopyrenes; Computers; Deoxyguanosine; DNA; Fluorenes; Models, Molecular; Naphthalenes; Nucleic Acid Conformation | 1978 |
Detection of carcinogen-DNA adducts by radiommunoassay.
Topics: 2-Acetylaminofluorene; Cells, Cultured; Deoxyguanosine; DNA; DNA, Bacterial; Fluorenes; Nucleic Acid Conformation; Radioimmunoassay | 1977 |
Metabolic activation in isolated rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Deoxyguanosine; DNA; DNA Damage; DNA Repair; Fluorenes; Liver; Male; Rats | 1990 |
DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Damage; Epoxide Hydrolases; Epoxy Compounds; Fluorenes; Injections, Intravenous; Liver; Male; Masoprocol; Rats; Rats, Inbred Strains; RNA; Trichloroepoxypropane; Trifluoroacetic Acid | 1991 |
Carcinogen-induced alterations in rat liver DNA adduct formation determined by computerized fluorescent image analysis.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Cell Nucleus; Computers; Deoxyguanosine; DNA; Fluorescent Antibody Technique; Liver; Male; Microscopy, Fluorescence; Rats; Rats, Inbred F344 | 1991 |
Isolation and characterization of oligodeoxynucleotides containing dG-N2-AAF and oxidation products of dG-C8-AF.
Topics: 2-Acetylaminofluorene; Chromatography, High Pressure Liquid; Deoxyguanosine; Electrophoresis, Polyacrylamide Gel; Fluorenes; Hydrogen-Ion Concentration; Mutagens; Oxidation-Reduction; Spectrophotometry, Ultraviolet | 1991 |
Induction of mutations by N-acetoxy-N-acetyl-2-aminofluorene modified M13 viral DNA.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Base Sequence; Coliphages; Deoxyguanosine; DNA, Viral; Frameshift Mutation; Molecular Sequence Data; Mutation; Plasmids; SOS Response, Genetics; Transfection | 1991 |
Detection and structural characterization of amino polyaromatic hydrocarbon-deoxynucleoside adducts using fast atom bombardment and tandem mass spectrometry.
Topics: 2-Acetylaminofluorene; Deoxyguanosine; DNA; Fluorenes; Molecular Structure; Phenanthrenes; Spectrometry, Mass, Fast Atom Bombardment | 1990 |
DNA adduct formation in relation to tumorigenesis in mice continuously administered 4-aminobiphenyl.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Animals; Carcinogens; Deoxyguanosine; DNA; DNA Damage; DNA Mutational Analysis; DNA, Neoplasm; DNA, Recombinant; Escherichia coli; Female; Fluorenes; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Organ Specificity; Sex Factors; Urinary Bladder Neoplasms | 1990 |
DNA adduct formation in relation to tumorigenesis in mice chronically fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Deoxyguanosine; DNA; DNA Damage; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Experimental; Mice; Urinary Bladder; Urinary Bladder Neoplasms | 1990 |
The fluorescence emission properties of dGuo-C8-AAF, dGuo-C8-AF and the imidazole ring-opened products of dGuo-C8-AF indicate a different dynamic structure for the various compounds.
Topics: 2-Acetylaminofluorene; Circular Dichroism; Deoxyguanosine; Fluorenes; Fluorescence; Imidazoles; Molecular Structure | 1990 |
Microfluorometric determination of DNA adducts in immunofluorescent-stained liver tissue from rats fed 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Bile Ducts; Deoxyguanosine; Epithelium; Fluorenes; Fluorescent Antibody Technique; Fluorometry; Liver; Male; Radioimmunoassay; Rats; Rats, Inbred F344; Staining and Labeling | 1987 |
Mutagenesis by single site-specific arylamine-DNA adducts. Induction of mutations at multiple sites.
Topics: 2-Acetylaminofluorene; Base Sequence; Coliphages; Deoxyguanosine; DNA, Viral; Escherichia coli; Fluorenes; Molecular Sequence Data; Mutagens; Mutation; Phenotype; Restriction Mapping; SOS Response, Genetics; Transfection | 1989 |
The role of specific DNA adducts in the induction of micronuclei by N-hydroxy-2-acetylaminofluorene in rat liver in vivo.
Topics: 2-Acetylaminofluorene; Animals; Cell Nucleus; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Liver; Liver Regeneration; Male; Mutagenicity Tests; Mutation; Pentachlorophenol; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Excited state properties of the N-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA; DNA Adducts; Fluorenes; Fluorescence; Spectrophotometry, Ultraviolet | 1989 |
NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].A[anti] pair formation and its pH dependence.
Topics: 2-Acetylaminofluorene; Adenosine; Chemical Phenomena; Chemistry, Physical; Deoxyguanosine; DNA; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation | 1989 |
Lack of acetylaminofluorene--DNA adduct formation in enzyme-altered foci of rat liver.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Deoxyguanosine; Fluorenes; Fluorescent Antibody Technique; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Histocytochemistry; Liver; Male; Rats; Rats, Inbred F344 | 1988 |
NMR study of stacking interactions and conformational adjustments in the dinucleotide-carcinogen adduct 2'-deoxycytidylyl-(3----5)-2'-deoxy-8-(N-fluoren-2-ylac etamido)guanosi ne.
Topics: 2-Acetylaminofluorene; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Deoxyguanosine; Dinucleoside Phosphates; Guanosine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Thermodynamics | 1988 |
The 32P-post-labeling method in quantitative DNA adduct dosimetry of 2-acetylaminofluorene-induced mutagenicity in Chinese hamster ovary cells and Salmonella typhimurium TA1538.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Cells, Cultured; Cricetinae; Deoxyguanosine; DNA; Dose-Response Relationship, Drug; Fluorenes; Mutagenicity Tests; Phosphorus Radioisotopes; Salmonella typhimurium | 1987 |
Conformational analysis of the 2'-deoxyribofuranose ring from proton-proton coupling constants: analysis of a nucleoside-carcinogen adduct formed from 2-acetylaminofluorene utilizing a three-state model.
Topics: 2-Acetylaminofluorene; Computer Simulation; Deoxyguanosine; Deoxyribose; Fluorenes; Models, Genetic; Models, Molecular; Molecular Conformation | 1987 |
Initiation of hepatocarcinogenesis in infant male B6C3F1 mice by N-hydroxy-2-aminofluorene or N-hydroxy-2-acetylaminofluorene depends primarily on metabolism to N-sulfooxy-2-aminofluorene and formation of DNA-(deoxyguanosin-8-yl)-2-aminofluorene adducts.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; Female; Fluorenes; Hydroxyacetylaminofluorene; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Pentachlorophenol; Phosphorus Radioisotopes; Tritium | 1987 |
Immunohistochemical localization of O6-ethyldeoxyguanosine and deoxyguanosin-8-yl-(acetyl)aminofluorene in liver sections of rats treated with diethylnitrosamine, ethylnitrosourea or N-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Deoxyguanosine; Diethylnitrosamine; DNA; Ethylnitrosourea; Female; Histocytochemistry; Immunoenzyme Techniques; Liver; Nitrosamines; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1985 |
Inhibition of enzymic incision of thymine dimers by covalently bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino]fluorene in deoxyribonucleic acid.
Topics: 2-Acetylaminofluorene; Deoxyguanosine; DNA; DNA Glycosylases; DNA Repair; N-Glycosyl Hydrolases; Pyrimidine Dimers; Ultraviolet Rays | 1985 |
Covalent binding of a carcinogen as a probe for the dynamics of deoxyribonucleic acid.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Animals; Cattle; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Kinetics; Mathematics; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Spectrophotometry; Stereoisomerism; Temperature | 1985 |
Conformation of 2-[(deoxyguanosin-8-ylacetyl)amino]fluorene differs in protein-free deoxyribonucleic acid and chromatin.
Topics: 2-Acetylaminofluorene; Animals; Cattle; Chromatin; Deoxyguanosine; DNA; Endonucleases; Fluorenes; In Vitro Techniques; Liver; Molecular Conformation; Nucleic Acid Conformation; Nucleosomes; Rats; Rats, Inbred Strains; Thymus Gland | 1982 |
Perturbations of enzymic uracil excision due to guanine modifications in DNA.
Topics: 2-Acetylaminofluorene; Bacillus subtilis; Bacteriophages; Deoxyguanosine; DNA Glycosylases; DNA, Viral; Kinetics; N-Glycosyl Hydrolases; Uracil; Uracil-DNA Glycosidase | 1984 |
AAF linked to the guanine amino group: a B-Z junction.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxycytosine Nucleotides; Deoxyguanosine; DNA; Guanine; Models, Molecular; Molecular Conformation; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides | 1983 |
Detection of N-hydroxy-2-acetylaminofluorene-DNA adducts in rat liver measured by radioimmunoassay.
Topics: 2-Acetylaminofluorene; Animals; Antibody Formation; Antibody Specificity; Deoxyguanosine; DNA; Hydroxyacetylaminofluorene; Injections, Intraperitoneal; Liver; Male; Methods; Radioimmunoassay; Rats; Rats, Inbred Lew | 1982 |
Force field conformational analysis of aminofluorene and acetylaminofluorene substituted deoxyguanosine.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxyguanosine; Fluorenes; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Thermodynamics | 1982 |
Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays.
Topics: 2-Acetylaminofluorene; Animals; Deoxyguanosine; DNA; Enzyme-Linked Immunosorbent Assay; Radioimmunoassay; Reference Values | 1982 |
Radioimmunoassay for 2-acetylaminofluorene-DNA adducts.
Topics: 2-Acetylaminofluorene; Animals; Cattle; Deoxyguanosine; DNA; Microchemistry; Rabbits; Radioimmunoassay | 1982 |
Conformation of the deoxydinucleoside monophosphate dCpdG modified at carbon 8 of guanine with 2-(acetylamino)fluorene.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry, Physical; Deoxycytosine Nucleotides; Deoxyguanosine; Guanine; Mathematics; Models, Molecular; Nucleic Acid Conformation | 1982 |
Conformation and dynamics associated with the site of attachment of a carcinogen to a nucleotide.
Topics: 2-Acetylaminofluorene; Binding Sites; Deoxyguanosine; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation | 1982 |
Structural identification of the pyrimidine derivatives formed from N-(deoxyguanosin-8-yl)-2-aminofluorene in aqueous solution at alkaline pH.
Topics: 2-Acetylaminofluorene; Chemical Phenomena; Chemistry; Deoxyguanosine; DNA; Fluorenes; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pyrimidines | 1980 |
Effect of culture conditions, cell type, and species of origin on the distribution of acetylated and deacetylated deoxyguanosine C-8 adducts of N-acetoxy-2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Acetylation; Animals; Cells, Cultured; Dealkylation; Deoxyguanosine; DNA; Epidermis; Liver; Mice; Paraoxon; Rats; Species Specificity | 1980 |
Effect of aminofluorene and (acetylamino)fluorene adducts on the DNA replication mediated by Escherichia coli polymerases I (Klenow fragment) and III.
Topics: 2-Acetylaminofluorene; Base Sequence; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Polymerase III; DNA Replication; DNA, Single-Stranded; Escherichia coli; Fluorenes; Molecular Sequence Data | 1995 |
Mutations induced by aromatic amine DNA adducts in pBR322.
Topics: 2-Acetylaminofluorene; Amines; Amino Acid Sequence; Aminobiphenyl Compounds; Benzidines; Deoxyguanosine; DNA; Escherichia coli; Fluorenes; Hydrocarbons; Molecular Sequence Data; Mutation; Plasmids; Pyrenes; Tetracycline Resistance; Transfection | 1994 |
Methods development toward the measurement of polyaromatic hydrocarbon-DNA adducts by mass spectrometry.
Topics: 2-Acetylaminofluorene; Animals; Benzene; Benzo(a)pyrene; Carcinogens, Environmental; Chromatography, Gas; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Electrophoresis; Fluorenes; Humans; Hydrazines; Hydrogenation; Mass Spectrometry; Oxidation-Reduction; Polycyclic Compounds; Pyrenes; Spectrometry, Mass, Fast Atom Bombardment; Superoxides | 1993 |
Solid-phase synthesis of oligonucleotides containing site-specific N-(2'-deoxyguanosin-8-yl)-2-(acetylamino)fluorene adducts using 9-fluorenylmethoxycarbonyl as the base-protecting group.
Topics: 2-Acetylaminofluorene; Base Sequence; Chromatography, High Pressure Liquid; Deoxyguanosine; Electrophoresis, Polyacrylamide Gel; Fluorenes; Guanine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oligodeoxyribonucleotides | 1993 |
Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Biomarkers; Deoxyguanosine; Diet; DNA; DNA Damage; DNA Repair; Fluorenes; Kinetics; Liver; Male; Rats; Rats, Inbred F344; Repetitive Sequences, Nucleic Acid | 1993 |
Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli.
Topics: 2-Acetylaminofluorene; Base Sequence; Carcinogens; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Replication; Escherichia coli; Fluorenes; Guanine; Molecular Sequence Data; Mutagenesis; Oligonucleotide Probes; Restriction Mapping; SOS Response, Genetics; Ultraviolet Rays | 1996 |
Leading versus lagging strand mutagenesis induced by 7,8-dihydro-8-oxo-2'-deoxyguanosine in Escherichia coli.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Adenosine; Adenosine Triphosphatases; Bacterial Proteins; Base Composition; Deoxyguanosine; DNA Adducts; DNA Glycosylases; DNA Helicases; DNA Repair; DNA Transposable Elements; DNA-Binding Proteins; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Frameshift Mutation; Guanine; Mutagenesis; Mutagenicity Tests; N-Glycosyl Hydrolases; Phosphoric Monoester Hydrolases; Plasmids; Polymerase Chain Reaction; Pyrophosphatases; Replication Origin; Thymine | 1997 |
Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Base Sequence; Binding Sites; Cattle; Deoxyguanosine; DNA Damage; DNA Polymerase III; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Fluorenes; Humans; Mammals; Mutagenesis; Proliferating Cell Nuclear Antigen; Recombinant Proteins; Templates, Genetic; Thymus Gland | 1997 |
Arylamine-DNA adduct conformation in relation to mutagenesis.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Aniline Compounds; Deoxyguanosine; DNA Adducts; Magnetic Resonance Spectroscopy; Mutagenesis; Nucleic Acid Conformation; Oligodeoxyribonucleotides | 1997 |
Electrochemical detection and quantification of the acetylated and deacetylated C8-deoxyguanosine DNA adducts induced by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Cattle; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Electrochemistry; In Vitro Techniques; Male; Mice; Mutagens | 1997 |
Lack of transcription-coupled repair of acetylaminofluorene DNA adducts in human fibroblasts contrasts their efficient inhibition of transcription.
Topics: 2-Acetylaminofluorene; Cells, Cultured; Deoxyguanosine; DNA Adducts; DNA Repair; DNA Replication; Fibroblasts; Humans; Transcription, Genetic | 1998 |
Mutagenic specificity of (acetylamino)fluorene-derived DNA adducts in mammalian cells.
Topics: 2-Acetylaminofluorene; Animals; Catalysis; COS Cells; Deoxyguanosine; DNA Adducts; DNA Polymerase I; DNA Primers; Fluorenes; Genetic Vectors; Mutagenesis, Insertional; Mutagens; Sequence Deletion; Transfection | 1998 |
Probing the conformational heterogeneity of the acetylaminofluorene-modified 2'-deoxyguanosine and DNA by 19F NMR spectroscopy.
Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA Adducts; DNA, Single-Stranded; Fluorenes; Fluorine; Models, Chemical; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Solvents; Thermodynamics | 1999 |
Solution structure of the N-(deoxyguanosin-8-yl)-1-aminopyrene ([AP]dG) adduct opposite dA in a DNA duplex.
Topics: 2-Acetylaminofluorene; Carbon; Carcinogens, Environmental; Crystallography, X-Ray; Deoxyguanosine; DNA Adducts; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Phosphorus; Protons; Pyrenes; Solutions | 1999 |
Specificity of DNA lesion bypass by the yeast DNA polymerase eta.
Topics: 2-Acetylaminofluorene; Apurinic Acid; Deoxyguanosine; DNA Damage; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; DNA, Fungal; Guanine; Polynucleotides; Pyrimidine Dimers; Saccharomyces cerevisiae | 2000 |
Total energy of deoxyguanosine bonded to N-2-acetylaminofluorene by the semi-empirical modified-neglect of differential diatomic overlap method.
Topics: 2-Acetylaminofluorene; Biomechanical Phenomena; Carcinogens; Deoxyguanosine; DNA; Hydrogen Bonding; Models, Molecular; Thermodynamics | 2001 |
Circular dichroism and proton magnetic resonance studies of dApdG modified with 2-aminofluorene and 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Circular Dichroism; Deoxyadenine Nucleotides; Deoxyguanosine; Fluorenes; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Spectrophotometry, Ultraviolet | 1980 |
Sensitivity of the conformation of deoxyguanosine to binding at the C-8 position by N-acetylated and unacetylated 2-aminofluorene.
Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA; Fluorenes; Mutagens; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrenes | 1980 |
Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA adducts in mammalian cells.
Topics: 2-Acetylaminofluorene; 3' Untranslated Regions; 5' Untranslated Regions; Animals; Base Sequence; Chlorocebus aethiops; COS Cells; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA Probes; Genetic Vectors; Mutagenesis, Site-Directed; Mutagens; Transfection | 2001 |
Translesional synthesis past acetylaminofluorene-derived DNA adducts catalyzed by human DNA polymerase kappa and Escherichia coli DNA polymerase IV.
Topics: 2-Acetylaminofluorene; Animals; Base Sequence; COS Cells; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA-Directed DNA Polymerase; Escherichia coli; Fluorenes; Humans; In Vitro Techniques; Kinetics; Mutagenesis, Site-Directed; Proteins; Recombinant Proteins; Sequence Deletion | 2001 |
The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.
Topics: 2-Acetylaminofluorene; Base Sequence; Chromatin; Deoxyguanosine; Deoxyribonucleases; DNA; DNA Footprinting; DNA Ligases; DNA Repair; DNA-Binding Proteins; Drosophila Proteins; Enzyme Activation; Humans; Macromolecular Substances; Models, Biological; Molecular Sequence Data; Nucleosomes; Replication Protein A; Ribonucleoprotein, U1 Small Nuclear; RNA-Binding Proteins; Substrate Specificity; Xeroderma Pigmentosum Group A Protein | 2002 |
Oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinogens; Catalase; Cattle; Chelating Agents; Copper; Cyclin-Dependent Kinase Inhibitor p16; Deoxyguanosine; DNA Damage; DNA, Neoplasm; Free Radical Scavengers; HL-60 Cells; Humans; Hydrogen Peroxide; NAD; Oxidation-Reduction; Phenanthrolines; Proto-Oncogene Proteins p21(ras); Spectrophotometry, Ultraviolet; Tumor Suppressor Protein p53 | 2002 |
Mutagenic events in Escherichia coli and mammalian cells generated in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site.
Topics: 2-Acetylaminofluorene; Animals; Chlorocebus aethiops; COS Cells; Deoxyguanosine; Deoxyribonucleases, Type II Site-Specific; DNA Adducts; DNA Mutational Analysis; DNA, Single-Stranded; Escherichia coli; Fluorenes; Frameshift Mutation; Mutagens; Oligodeoxyribonucleotides; Plasmids; Point Mutation | 2002 |
Effect of damage type on stimulation of human excision nuclease by SWI/SNF chromatin remodeling factor.
Topics: 2-Acetylaminofluorene; Base Sequence; Chromatin; Chromosomal Proteins, Non-Histone; Deoxyguanosine; Deoxyribonuclease I; Deoxyribonucleases; Dimerization; DNA Damage; DNA Repair; Electrophoresis, Polyacrylamide Gel; Endodeoxyribonucleases; Escherichia coli Proteins; HeLa Cells; Humans; Light; Molecular Sequence Data; Nucleosomes; Pyrimidine Dimers; Time Factors; Transcription Factors | 2003 |
Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein.
Topics: 2-Acetylaminofluorene; Base Sequence; Deoxycytidine Monophosphate; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA-Directed DNA Polymerase; Mutagenesis; Nucleotidyltransferases; Saccharomyces cerevisiae Proteins; Templates, Genetic; Yeasts | 2004 |
Mutagenic properties of 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene, a persistent acetylaminofluorene-derived DNA adduct in mammalian cells.
Topics: 2-Acetylaminofluorene; Animals; Base Pair Mismatch; Base Sequence; Chlorocebus aethiops; COS Cells; Deoxyguanosine; Deoxyribonucleotides; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA Repair; DNA-Directed DNA Polymerase; Genetic Vectors; Kinetics; Molecular Conformation; Molecular Structure; Mutagenesis, Site-Directed; Mutagens; Templates, Genetic | 2004 |
Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified 'ultra-mild' DNA synthesis.
Topics: 2-Acetylaminofluorene; Biochemistry; Deoxyguanosine; DNA Adducts; DNA Repair; Fluorenes; HeLa Cells; Humans; Oligodeoxyribonucleotides | 2005 |
Time-resolved resonance Raman observation of the 2-fluorenylnitrenium ion reaction with guanosine to form a C8 intermediate.
Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA Adducts; DNA Damage; Guanosine; Ions; Spectrum Analysis, Raman | 2005 |
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).
Topics: 2-Acetylaminofluorene; Base Pairing; Binding Sites; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanosine; DNA Adducts; DNA Polymerase beta; DNA Replication; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Sulfolobus solfataricus | 2006 |
Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing?
Topics: 2-Acetylaminofluorene; Base Pairing; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA Polymerase iota; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Structure; Thermodynamics | 2009 |
Mechanism of acetylaminofluorene-dG induced frameshifting by polymerase η.
Topics: 2-Acetylaminofluorene; Base Sequence; Cloning, Molecular; Deoxyguanosine; DNA; DNA Damage; DNA-Directed DNA Polymerase; Escherichia coli; Frameshift Mutation; Saccharomyces cerevisiae; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Base Sequence; Calorimetry; Circular Dichroism; Deoxyguanosine; Deoxyribonucleases, Type II Site-Specific; DNA Adducts; DNA Repair; DNA-Binding Proteins; Escherichia coli Proteins; Fluorenes; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Nucleic Acid Denaturation; Spectrometry, Mass, Electrospray Ionization; Thermodynamics | 2012 |
Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies.
Topics: 2-Acetylaminofluorene; Base Sequence; Deoxyguanosine; DNA Adducts; DNA Repair; Fluorenes; HeLa Cells; Humans; Molecular Dynamics Simulation; Nucleic Acid Conformation | 2012 |
Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor.
Topics: 2-Acetylaminofluorene; Aminobiphenyl Compounds; Base Sequence; Circular Dichroism; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; Electrophoretic Mobility Shift Assay; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Fluorenes; Models, Molecular; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Thermodynamics | 2013 |
Carcinogenic adducts induce distinct DNA polymerase binding orientations.
Topics: 2-Acetylaminofluorene; Carcinogens; Deoxyguanosine; DNA; DNA Adducts; DNA Polymerase I; Fluorenes; Fluorometry; Protein Binding | 2013 |
Structural and dynamic characterization of polymerase κ's minor groove lesion processing reveals how adduct topology impacts fidelity.
Topics: 2-Acetylaminofluorene; Base Pair Mismatch; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Molecular Dynamics Simulation; Protein Conformation; Substrate Specificity | 2014 |