Compounds > 2-acetyl-4(5)-tetrahydroxybutylimidazole
Page last updated: 2024-09-02

2-acetyl-4(5)-tetrahydroxybutylimidazole and sphingosine

2-acetyl-4(5)-tetrahydroxybutylimidazole has been researched along with sphingosine in 7 studies

Compound Research Comparison

Studies
(2-acetyl-4(5)-tetrahydroxybutylimidazole)		Trials
(2-acetyl-4(5)-tetrahydroxybutylimidazole)		Recent Studies (post-2010)
(2-acetyl-4(5)-tetrahydroxybutylimidazole)		Studies
(sphingosine)		Trials
(sphingosine)		Recent Studies (post-2010) (sphingosine)
430118,3251173,459

Protein Interaction Comparison

ProteinTaxonomy2-acetyl-4(5)-tetrahydroxybutylimidazole (IC50)sphingosine (IC50)
ubiquitin-conjugating enzyme E2 NHomo sapiens (human)6.3125
cAMP-dependent protein kinase catalytic subunit alpha Rattus norvegicus (Norway rat)0.098
Sphingosine kinase 2Homo sapiens (human)1.56
Sphingosine kinase 1Homo sapiens (human)3.86

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hla, T1
Cyster, JG; Huang, Y; Matloubian, M; Pereira, JP; Schwab, SR; Xu, Y1
Kramer, J; Moran, L; Nouraldeen, A; O'Neill, E; Oravecz, T; Wilson, AG; Yu, XQ1
Beiser, DG; Berdyshev, EV; Gorshkova, IA; Goya, J; Natarajan, V; Orbelyan, GA; Vanden Hoek, TL; Wang, H1
Allegood, J; Fischer, K; Hait, NC; Hays, A; Ieronimakis, N; Nguyen-Tran, DH; Pantoja, M; Qi, J; Reyes, M; Ruohola-Baker, H; Sperber, H; Spiegel, S1
Chiba, K; Fukunari, A; Maeda, Y; Masuko, T; Sugahara, K; Takemoto, K; Utsumi, H; Yagi, H1
Abe, K; Chiba, J; Hagihara, K; Hashimoto, R; Inoue, R; Kita, Y; Kobayashi, Y; Machinaga, N; Muro, F; Nagasaki, M; Ohtoyo, M; Shimozato, T; Tamura, M; Watanabe, J; Yuita, H1

Other Studies

7 other study(ies) available for 2-acetyl-4(5)-tetrahydroxybutylimidazole and sphingosine

ArticleYear
Immunology. Dietary factors and immunological consequences.
    Science (New York, N.Y.), 2005, Sep-09, Volume: 309, Issue:5741

    Topics: Aldehyde-Lyases; Animals; Cell Movement; Chemotaxis, Leukocyte; Diet; Enzyme Inhibitors; Fingolimod Hydrochloride; Food Coloring Agents; Imidazoles; Immunosuppressive Agents; Lymphoid Tissue; Lysophospholipids; Mice; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; T-Lymphocytes

2005
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
    Science (New York, N.Y.), 2005, Sep-09, Volume: 309, Issue:5741

    Topics: Aldehyde-Lyases; Animals; B-Lymphocytes; Chemotaxis, Leukocyte; Enzyme Inhibitors; Food Coloring Agents; Hematopoietic Stem Cells; Imidazoles; Immunosuppressive Agents; Lymph; Lymph Nodes; Lymphoid Tissue; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Pyridoxine; Receptors, Lysosphingolipid; RNA Interference; Sphingosine; T-Lymphocytes; Thymus Gland; Vitamin B 6

2005
Pharmacokinetic/pharmacodynamic modelling of 2-acetyl-4(5)-tetrahydroxybutyl imidazole-induced peripheral lymphocyte sequestration through increasing lymphoid sphingosine 1-phosphate.
    Xenobiotica; the fate of foreign compounds in biological systems, 2010, Volume: 40, Issue:5

    Topics: Administration, Oral; Animals; Computer Simulation; Imidazoles; Lymphocytes; Lysophospholipids; Male; Mice; Models, Biological; Rats; Rats, Sprague-Dawley; Sphingosine; Spleen; Time Factors

2010
Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.
    Life sciences, 2013, Sep-17, Volume: 93, Issue:9-11

    Topics: Aldehyde-Lyases; Animals; Cardiopulmonary Resuscitation; Ceramides; Chromatography, Liquid; Disease Models, Animal; Female; Gene Expression Regulation; Heart Arrest; Imidazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Sphingosine; Sphingosine-1-Phosphate Receptors; Survival Rate; Tandem Mass Spectrometry

2013
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy.
    Disease models & mechanisms, 2014, Volume: 7, Issue:1

    Topics: Acetylation; Aldehyde-Lyases; Animals; Cell Nucleus; Down-Regulation; Histone Deacetylases; Histones; Imidazoles; Inflammation; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; MicroRNAs; Mitochondria; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Oligonucleotide Array Sequence Analysis; Phenotype; Protein Kinases; Regeneration; Sarcomeres; Sphingosine; Tissue Distribution

2014
S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1.
    International immunology, 2014, Volume: 26, Issue:5

    Topics: Aldehyde-Lyases; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Blood Vessels; Blotting, Western; Cell Movement; Extracellular Space; Female; Fingolimod Hydrochloride; Imidazoles; Immunohistochemistry; L-Selectin; Lectins, C-Type; Lysophospholipids; Male; Mice, Inbred C57BL; Microscopy, Confocal; Platelet Endothelial Cell Adhesion Molecule-1; Propylene Glycols; Rats, Inbred F344; Receptors, Lysosphingolipid; Sphingosine; Thymocytes; Thymus Gland; Time Factors; Up-Regulation

2014
Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate.
    Cell chemical biology, 2016, 05-19, Volume: 23, Issue:5

    Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Food Coloring Agents; Imidazoles; Lymphopenia; Lysophospholipids; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred Lew; Sphingosine; Structure-Activity Relationship

2016